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This review provides a comprehensive evaluation of the molecular and cellular functions of these pathways, with a focus on their involvement in cytoskeletal dynamics, cellular polarity, and calcium signaling. Non-canonical Wnt signaling is essential for key neurodevelopmental processes, including neural tube closure, neuronal migration, axon guidance, and synaptic plasticity, while its dysregulation contributes to the pathogenesis of both neurodevelopmental and neurodegenerative disorders such as autism spectrum disorder, spina bifida, Alzheimer\u2019s disease, and Parkinson\u2019s disease. Particular emphasis is placed on the role of Dishevelled (DVL) as a shared intracellular signaling mediator across canonical and non-canonical Wnt pathways, as well as on the context-dependent activation of downstream effectors including Rho GTPases, protein kinase C (PKC), calcium\/calmodulin-dependent kinase II (CaMKII), and nuclear factor of activated T-cells (NFAT). In addition, emerging experimental platforms, including CRISPR\/Cas9 gene editing and human brain organoids, are highlighted for their utility in dissecting pathway-specific mechanisms and advancing translational applications. Overall, this review underscores the importance of non-canonical Wnt signaling as a dynamic and context-dependent regulatory network and discusses its potential as a target for precision-based therapeutic strategies in neurological disorders.<\/jats:p>","DOI":"10.1007\/s11033-026-12120-2","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T10:34:28Z","timestamp":1781087668000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unravel\u0131ng non-canon\u0131cal Wnt s\u0131gnal\u0131ng \u0131n neural development and d\u0131sorders: a rev\u0131ew of Wnt\/PCP and Wnt\/ca\u00b2\u207a pathways"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8199-390X","authenticated-orcid":false,"given":"Ahmet Alperen","family":"Palabiyik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3066-1921","authenticated-orcid":false,"given":"Esra","family":"Palabiyik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"12120_CR1","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1002\/cbin.11797","volume":"46","author":"R Hayat","year":"2022","unstructured":"Hayat R, Manzoor M, Hussain A (2022) Wnt signaling pathway: a comprehensive review. 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This study did not involve any new experiments with human participants or animals.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The authors declare that ChatGPT (OpenAI, GPT-5.2) was used exclusively for language polishing and minor grammatical corrections during manuscript preparation.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Generative AI Use"}}],"article-number":"929"}}