{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:13:54Z","timestamp":1787508834728,"version":"build-2736575974"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12178-y","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:43:19Z","timestamp":1781876599000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Promoter methylation of TXNIP and ADRB3 genes: potential blood-based biomarkers for metabolic syndrome"],"prefix":"10.1007","volume":"53","author":[{"given":"Saeed Esmaeili","family":"Dizghandi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Mostafapour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Khodabandehloo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behrang","family":"Alani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Saremi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiebe","family":"Kenarangi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meysam","family":"Mosallaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boshra","family":"Rezvankhah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"12178_CR1","doi-asserted-by":"crossref","unstructured":"Ahire ED, Surana KR, Sonawane VN, Talele SG, Talele GS, Kshirsagar SJ, Khairnar SJ, Thombre NA (2023) The metabolic syndrome: A concerning area for future research. The Metabolic Syndrome. Apple Academic, pp 231\u2013249","DOI":"10.1201\/9781003329732-11"},{"issue":"1","key":"12178_CR2","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1093\/toxsci\/kfx233","volume":"162","author":"DL Mendrick","year":"2018","unstructured":"Mendrick DL, Diehl AM, Topor LS, Dietert RR, Will Y, La Merrill MA, Bouret S, Varma V, Hastings KL, Schug TT (2018) Metabolic syndrome and associated diseases: from the bench to the clinic. Toxicol Sci 162(1):36\u201342","journal-title":"Toxicol Sci"},{"issue":"1","key":"12178_CR3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/s41572-024-00563-5","volume":"10","author":"IJ Neeland","year":"2024","unstructured":"Neeland IJ, Lim S, Tchernof A, Gastaldelli A, Rangaswami J, Ndumele CE, Powell-Wiley TM, Despr\u00e9s J-P (2024) Metabolic syndrome. Nat Reviews Disease Primers 10(1):77","journal-title":"Nat Reviews Disease Primers"},{"key":"12178_CR4","doi-asserted-by":"publisher","first-page":"109924","DOI":"10.1016\/j.diabres.2022.109924","volume":"188","author":"JJ Noubiap","year":"2022","unstructured":"Noubiap JJ, Nansseu JR, Lontchi-Yimagou E, Nkeck JR, Nyaga UF, Ngouo AT, Tounouga DN, Tianyi F-L, Foka AJ, Ndoadoumgue AL (2022) Geographic distribution of metabolic syndrome and its components in the general adult population: A meta-analysis of global data from 28 million individuals. Diabetes Res Clin Pract 188:109924","journal-title":"Diabetes Res Clin Pract"},{"key":"12178_CR5","doi-asserted-by":"publisher","unstructured":"Lin L, Tan W, Pan X, Tian E, Wu Z, Yang J (2022) Metabolic syndrome-related kidney injury: a review and update. Front Endocrinol (Lausanne). 2022; 13: 904001. Epub 2022\/07\/12. https:\/\/doi.org\/10.3389\/fendo. 2022.904001 PMID: 35813613","DOI":"10.3389\/fendo"},{"issue":"4","key":"12178_CR6","doi-asserted-by":"publisher","first-page":"273","DOI":"10.26502\/aimr.0184","volume":"7","author":"R Patial","year":"2024","unstructured":"Patial R, Batta I, Thakur M, Sobti RC, Agrawal DK (2024) Etiology, pathophysiology, and treatment strategies in the prevention and management of metabolic syndrome. Archives Intern Med Res 7(4):273","journal-title":"Archives Intern Med Res"},{"issue":"03","key":"12178_CR7","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1055\/a-1263-0898","volume":"42","author":"A Bovolini","year":"2021","unstructured":"Bovolini A, Garcia J, Andrade MA, Duarte JA (2021) Metabolic syndrome pathophysiology and predisposing factors. Int J Sports Med 42(03):199\u2013214","journal-title":"Int J Sports Med"},{"issue":"2","key":"12178_CR8","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s13237-023-00420-y","volume":"66","author":"S Ghosh","year":"2023","unstructured":"Ghosh S, Dhar S, Bhattacharjee S, Bhattacharjee P (2023) Contribution of environmental, genetic and epigenetic factors to obesity-related metabolic syndrome. Nucleus 66(2):215\u2013237","journal-title":"Nucleus"},{"issue":"11","key":"12178_CR9","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1152\/physiolgenomics.00072.2018","volume":"50","author":"C Carson","year":"2018","unstructured":"Carson C, Lawson HA (2018) Epigenetics of metabolic syndrome. Physiol Genom 50(11):947\u2013955","journal-title":"Physiol Genom"},{"issue":"5","key":"12178_CR10","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1080\/15592294.2019.1595297","volume":"14","author":"M Samblas","year":"2019","unstructured":"Samblas M, Milagro FI, Mart\u00ednez A (2019) DNA methylation markers in obesity, metabolic syndrome, and weight loss. Epigenetics 14(5):421\u2013444","journal-title":"Epigenetics"},{"key":"12178_CR11","doi-asserted-by":"publisher","first-page":"1184661","DOI":"10.3389\/fgene.2023.1184661","volume":"14","author":"AC Jones","year":"2023","unstructured":"Jones AC, Ament Z, Patki A, Chaudhary NS, Srinivasasainagendra V, Kijpaisalratana N, Absher DM, Tiwari HK, Arnett DK, Kimberly WT, Irvin MR (2023) Metabolite profiles and DNA methylation in metabolic syndrome: a two-sample, bidirectional Mendelian randomization. Front Genet 14:1184661. https:\/\/doi.org\/10.3389\/fgene.2023.1184661","journal-title":"Front Genet"},{"issue":"1","key":"12178_CR12","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s13148-024-01671-5","volume":"16","author":"H-S Lee","year":"2024","unstructured":"Lee H-S, Kim B, Park T (2024) Genome-and epigenome-wide association studies identify susceptibility of CpG sites and regions for metabolic syndrome in a Korean population. Clin Epigenetics 16(1):60","journal-title":"Clin Epigenetics"},{"issue":"1","key":"12178_CR13","doi-asserted-by":"publisher","first-page":"20567","DOI":"10.1038\/s41598-020-77506-z","volume":"10","author":"ML Nuotio","year":"2020","unstructured":"Nuotio ML, Pervjakova N, Joensuu A, Karhunen V, Hiekkalinna T, Milani L, Kettunen J, J\u00e4rvelin MR, Jousilahti P, Metspalu A, Salomaa V, Kristiansson K, Perola M (2020) An epigenome-wide association study of metabolic syndrome and its components. Sci Rep 10(1):20567. https:\/\/doi.org\/10.1038\/s41598-020-77506-z","journal-title":"Sci Rep"},{"key":"12178_CR14","doi-asserted-by":"publisher","first-page":"514","DOI":"10.3389\/fimmu.2013.00514","volume":"4","author":"E Yoshihara","year":"2014","unstructured":"Yoshihara E, Masaki S, Matsuo Y, Chen Z, Tian H, Yodoi J (2014) Thioredoxin\/Txnip: redoxisome, as a redox switch for the pathogenesis of diseases. Front Immunol 4:514","journal-title":"Front Immunol"},{"key":"12178_CR15","doi-asserted-by":"crossref","unstructured":"Maimaiti S (2026) Molecular mechanisms of cellular control through the TXNIP protein. Karolinska Institutet","DOI":"10.69622\/31398063.v1"},{"issue":"5","key":"12178_CR16","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1017\/thg.2021.42","volume":"24","author":"Y Xiang","year":"2021","unstructured":"Xiang Y, Wang Z, Hui Q, Gwinn M, Vaccarino V, Sun YV (2021) DNA methylation of TXNIP independently associated with inflammation and diabetes mellitus in twins. Twin Res Hum Genet 24(5):273\u2013280. https:\/\/doi.org\/10.1017\/thg.2021.42","journal-title":"Twin Res Hum Genet"},{"issue":"7","key":"12178_CR17","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/s10038-024-01243-8","volume":"69","author":"Y Wu","year":"2024","unstructured":"Wu Y, Chen W, Zhao Y, Gu M, Gao Y, Ke Y, Wang L, Wang M, Zhang W, Chen Y, Huo W, Fu X, Li X, Zhang D, Qin P, Hu F, Liu Y, Sun X, Zhang M, Hu D (2024) Visit to visit transition in TXNIP gene methylation and the risk of type 2 diabetes mellitus: a nested case-control study. J Hum Genet 69(7):311\u2013319. https:\/\/doi.org\/10.1038\/s10038-024-01243-8","journal-title":"J Hum Genet"},{"key":"12178_CR18","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/bs.pmbts.2018.09.003","volume":"161","author":"L-K Yang","year":"2019","unstructured":"Yang L-K, Tao Y-X (2019) Physiology and pathophysiology of the \u03b23-adrenergic receptor. Prog Mol Biol Transl Sci 161:91\u2013112","journal-title":"Prog Mol Biol Transl Sci"},{"key":"12178_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev-physiol-060721-092939","volume":"84","author":"S Collins","year":"2022","unstructured":"Collins S (2022) \u03b2-Adrenergic receptors and adipose tissue metabolism: evolution of an old story. Annu Rev Physiol 84:1\u201316","journal-title":"Annu Rev Physiol"},{"issue":"11","key":"12178_CR20","doi-asserted-by":"publisher","first-page":"e139160","DOI":"10.1172\/jci.insight.139160","volume":"6","author":"C Cero","year":"2021","unstructured":"Cero C, Lea HJ, Zhu KY, Shamsi F, Tseng Y-H, Cypess AM (2021) \u03b23-Adrenergic receptors regulate human brown\/beige adipocyte lipolysis and thermogenesis. JCI insight 6(11):e139160","journal-title":"JCI insight"},{"issue":"1","key":"12178_CR21","doi-asserted-by":"publisher","first-page":"33","DOI":"10.2217\/epi.13.82","volume":"6","author":"S-P Guay","year":"2014","unstructured":"Guay S-P, Brisson D, Lamarche B, Biron S, Lescelleur O, Biertho L, Marceau S, Vohl M-C, Gaudet D, Bouchard L (2014) ADRB3 gene promoter DNA methylation in blood and visceral adipose tissue is associated with metabolic disturbances in men. Epigenomics 6(1):33\u201343","journal-title":"Epigenomics"},{"key":"12178_CR22","doi-asserted-by":"crossref","unstructured":"Lima RPA, Ribeiro MR, Lima KQF, EAd S, Luna CDO, Moraes RMd (2019) RCP, Nascimento RAFd, Gon\u00e7alves MdCR, Vianna RPdT, Methylation profile of the ADRB3 gene and its association with lipid profile and nutritional status in adults. Biological Research 52","DOI":"10.1186\/s40659-019-0226-7"},{"key":"12178_CR23","doi-asserted-by":"crossref","unstructured":"Diani LM, Watanabe LM, Noronha NY, da Silva Rodrigues G, de Souza Pinhel MA, Sae-Lee C, de Oliveira BAP, Nicoletti CF, Junqueira GP, Salgado W Jr (2026) The epigenetic role of ADRB3 DNA methylation in post-bariatric energy expenditure for women with obesity: a longitudinal observational study. Scientific Reports","DOI":"10.21203\/rs.3.rs-7935014\/v1"},{"issue":"12","key":"12178_CR24","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/labinvest.2008.100","volume":"88","author":"M Bettstetter","year":"2008","unstructured":"Bettstetter M, Dechant S, Ruemmele P, Vogel C, Kurz K, Morak M, Keller G, Holinski-Feder E, Hofstaedter F, Dietmaier W (2008) MethyQESD, a robust and fast method for quantitative methylation analyses in HNPCC diagnostics using formalin-fixed and paraffin-embedded tissue samples. Lab Invest 88(12):1367\u20131375","journal-title":"Lab Invest"},{"issue":"19","key":"12178_CR25","doi-asserted-by":"publisher","first-page":"4251","DOI":"10.3390\/nu15194251","volume":"15","author":"O Ramos-Lopez","year":"2023","unstructured":"Ramos-Lopez O (2023) Epigenetic biomarkers of metabolic responses to lifestyle interventions. Nutrients 15(19):4251","journal-title":"Nutrients"},{"issue":"1","key":"12178_CR26","doi-asserted-by":"publisher","first-page":"20567","DOI":"10.1038\/s41598-020-77506-z","volume":"10","author":"M-L Nuotio","year":"2020","unstructured":"Nuotio M-L, Pervjakova N, Joensuu A, Karhunen V, Hiekkalinna T, Milani L, Kettunen J, J\u00e4rvelin M-R, Jousilahti P, Metspalu A (2020) An epigenome-wide association study of metabolic syndrome and its components. Sci Rep 10(1):20567","journal-title":"Sci Rep"},{"issue":"2","key":"12178_CR27","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1161\/CIRCGENETICS.114.000804","volume":"8","author":"L Pfeiffer","year":"2015","unstructured":"Pfeiffer L, Wahl S, Pilling L, Reischl E, Sandling J, Kunze S (2015) DNA methylation of lipid-related genes affects blood lipid levels. Circ Cardiovasc Genet 8(2):334\u2013342 This epigenome-wide study conducted in multiple European cohorts established that the differential lipid-related methylation patterns observed in blood also hold true in adipose tissue, and reported robust relationships between methylation and gene expression Article CAS PubMed PubMed Central","journal-title":"Circ Cardiovasc Genet"},{"issue":"9","key":"12178_CR28","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1080\/15592294.2016.1216284","volume":"11","author":"O Ali","year":"2016","unstructured":"Ali O, Cerjak D, Kent JW Jr., James R, Blangero J, Carless MA, Zhang Y (2016) Methylation of SOCS3 is inversely associated with metabolic syndrome in an epigenome-wide association study of obesity. Epigenetics 11(9):699\u2013707. https:\/\/doi.org\/10.1080\/15592294.2016.1216284","journal-title":"Epigenetics"},{"issue":"1","key":"12178_CR29","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s40200-026-01881-z","volume":"25","author":"B Rezvankhah","year":"2026","unstructured":"Rezvankhah B, Ehtesham N, Hajali MH, Sadeghi S, Alani B, Kenarangi T, Mosallaei M, Mirjani R (2026) Methylation analysis of PHOSPHO1 and ACACA gene promoters in whole blood samples: insights into metabolic syndrome and associated factors. J Diabetes Metabolic Disorders 25(1):51","journal-title":"J Diabetes Metabolic Disorders"},{"issue":"8","key":"12178_CR30","doi-asserted-by":"publisher","first-page":"765","DOI":"10.3390\/antiox9080765","volume":"9","author":"E Yoshihara","year":"2020","unstructured":"Yoshihara E (2020) TXNIP\/TBP-2: a master regulator for glucose homeostasis. Antioxidants 9(8):765","journal-title":"Antioxidants"},{"key":"12178_CR31","doi-asserted-by":"crossref","unstructured":"Pan M, Zhang F, Qu K, Liu C, Zhang J (2022) TXNIP: a double-edged sword in disease and therapeutic outlook. Oxidative Medicine and Cellular Longevity 2022 (1):7805115","DOI":"10.1155\/2022\/7805115"},{"issue":"2","key":"12178_CR32","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1097\/MED.0000000000000391","volume":"25","author":"L Thielen","year":"2018","unstructured":"Thielen L, Shalev A (2018) Diabetes pathogenic mechanisms and potential new therapies based upon a novel target called TXNIP. Curr Opin Endocrinol Diabetes Obes 25(2):75\u201380","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"8","key":"12178_CR33","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1210\/me.2014-1095","volume":"28","author":"A Shalev","year":"2014","unstructured":"Shalev A (2014) Minireview: Thioredoxin-interacting protein: regulation and function in the pancreatic \u03b2-cell. Mol Endocrinol 28(8):1211\u20131220. https:\/\/doi.org\/10.1210\/me.2014-1095","journal-title":"Mol Endocrinol"},{"key":"12178_CR34","doi-asserted-by":"publisher","first-page":"e21065","DOI":"10.7717\/peerj.21065","volume":"14","author":"Z He","year":"2026","unstructured":"He Z, Liu Q, Yue X, Zhao H, Yu J, Zhang L, Wang Y, Zhao B, Yang X, Wang Z (2026) Coupled endoplasmic reticulum and oxidative stress in pancreatic \u03b2 cells: mechanisms and therapeutic insights. PeerJ 14:e21065","journal-title":"PeerJ"},{"issue":"7","key":"12178_CR35","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1038\/s12276-023-01019-8","volume":"55","author":"E-H Choi","year":"2023","unstructured":"Choi E-H, Park S-J (2023) TXNIP: A key protein in the cellular stress response pathway and a potential therapeutic target. Exp Mol Med 55(7):1348\u20131356","journal-title":"Exp Mol Med"},{"issue":"18","key":"12178_CR36","doi-asserted-by":"publisher","first-page":"6022","DOI":"10.3390\/jcm12186022","volume":"12","author":"IM Ni\u021bulescu","year":"2023","unstructured":"Ni\u021bulescu IM, Ciulei G, Cozma A, Procopciuc LM, Or\u0103\u0219an OH (2023) From innate immunity to metabolic disorder: a review of the NLRP3 inflammasome in diabetes mellitus. J Clin Med 12(18):6022","journal-title":"J Clin Med"},{"issue":"3","key":"12178_CR37","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1507\/endocrj.EJ21-0339","volume":"69","author":"M Yamazaki","year":"2022","unstructured":"Yamazaki M, Yamada H, Munetsuna E, Maeda K, Ando Y, Mizuno G, Fujii R, Tsuboi Y, Ohashi K, Ishikawa H (2022) DNA methylation level of the gene encoding thioredoxin-interacting protein in peripheral blood cells is associated with metabolic syndrome in the Japanese general population. Endocr J 69(3):319\u2013326","journal-title":"Endocr J"},{"issue":"7","key":"12178_CR38","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1111\/1753-0407.13021","volume":"12","author":"D Zhang","year":"2020","unstructured":"Zhang D, Cheng C, Cao M, Wang T, Chen X, Zhao Y, Wang B, Ren Y, Liu D, Liu L (2020) TXNIP hypomethylation and its interaction with obesity and hypertriglyceridemia increase type 2 diabetes mellitus risk: a nested case-control study. J Diabetes 12(7):512\u2013520","journal-title":"J Diabetes"},{"issue":"6","key":"12178_CR39","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1507\/endocrj.EJ23-0629","volume":"71","author":"K Maeda","year":"2024","unstructured":"Maeda K, Fujii R, Yamada H, Munetsuna E, Yamazaki M, Ando Y, Mizuno G, Ishikawa H, Ohashi K, Tsuboi Y (2024) Association between DNA methylation levels of thioredoxin-interacting protein (TXNIP) and changes in glycemic traits: a longitudinal population-based study. Endocr J 71(6):593\u2013601","journal-title":"Endocr J"},{"issue":"6","key":"12178_CR40","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1038\/s41366-022-01084-5","volume":"46","author":"X Li","year":"2022","unstructured":"Li X, Shao X, Bazzano LA, Xue Q, Koseva BS, Grundberg E, Shai I, Bray GA, Sacks FM, Qi L (2022) Blood DNA methylation at TXNIP and glycemic changes in response to weight-loss diet interventions: the POUNDS lost trial. Int J Obes 46(6):1122\u20131127. https:\/\/doi.org\/10.1038\/s41366-022-01084-5","journal-title":"Int J Obes"},{"key":"12178_CR41","doi-asserted-by":"crossref","unstructured":"Valentine JM, Ahmadian M, Keinan O, Abu-Odeh M, Zhao P, Zhou X, Keller MP, Gao H, Yu RT, Liddle C (2022) \u03b23-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity. J Clin Investig 132 (2)","DOI":"10.1172\/JCI153357"},{"issue":"10","key":"12178_CR42","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/s41574-021-00546-6","volume":"17","author":"C Auger","year":"2021","unstructured":"Auger C, Kajimura S (2021) Detouring adrenergic stimulation to induce adipose thermogenesis. Nat Rev Endocrinol 17(10):579\u2013580. https:\/\/doi.org\/10.1038\/s41574-021-00546-6","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"12178_CR43","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s12944-020-01290-y","volume":"19","author":"Z Luo","year":"2020","unstructured":"Luo Z, Zhang T, Wang S, He Y, Ye Q, Cao W (2020) The Trp64Arg polymorphism in \u03b23 adrenergic receptor (ADRB3) gene is associated with adipokines and plasma lipids: a systematic review, meta-analysis, and meta-regression. Lipids Health Dis 19(1):99. https:\/\/doi.org\/10.1186\/s12944-020-01290-y","journal-title":"Lipids Health Dis"},{"issue":"6","key":"12178_CR44","first-page":"1327","volume":"29","author":"AI Burguete-Garc\u00eda","year":"2014","unstructured":"Burguete-Garc\u00eda AI, Mart\u00ednez-Nava GA, Valladares-Salgado A, Berm\u00fadez V, Estrada-Velasco B, Wacher N, Peralta-Romero J, Garcia-Mena J, Parra E, Cruz M (2014) Association of b1 and b3 adrenergic receptors gene polymorphisms with insulin resistance and high lipid profiles related to type 2 diabetes and metabolic syndrome. Nutrici\u00f3n hospitalaria 29(6):1327\u20131334","journal-title":"Nutrici\u00f3n hospitalaria"},{"issue":"8","key":"12178_CR45","doi-asserted-by":"publisher","first-page":"e0255444","DOI":"10.1371\/journal.pone.0255444","volume":"16","author":"Y Yamada","year":"2021","unstructured":"Yamada Y, Nakamura H, Tsujiguchi H, Hara A, Miyagi S, Kannon T, Sato T, Hosomichi K, Nguyen TTT, Kambayashi Y, Shimizu Y, Pham KO, Suzuki K, Suzuki F, Kasahara T, Tsuboi H, Tajima A, Nakamura H (2021) Relationships among the \u03b23-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population. PLoS ONE 16(8):e0255444. https:\/\/doi.org\/10.1371\/journal.pone.0255444","journal-title":"PLoS ONE"},{"issue":"11","key":"12178_CR46","doi-asserted-by":"publisher","first-page":"5721","DOI":"10.3390\/ijms22115721","volume":"22","author":"E Haji","year":"2021","unstructured":"Haji E, Al Mahri S, Aloraij Y, Malik SS, Mohammad S (2021) Functional characterization of the obesity-linked variant of the \u03b23-adrenergic receptor. Int J Mol Sci 22(11):5721","journal-title":"Int J Mol Sci"},{"issue":"3","key":"12178_CR47","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1111\/jdi.12426","volume":"7","author":"N Sakane","year":"2016","unstructured":"Sakane N, Sato J, Tsushita K, Tsujii S, Kotani K, Tominaga M, Kawazu S, Sato Y, Usui T, Kamae I, Yoshida T, Kiyohara Y, Sato S, Tsuzaki K, Takahashi K, Kuzuya H (2016) Effects of lifestyle intervention on weight and metabolic parameters in patients with impaired glucose tolerance related to beta-3 adrenergic receptor gene polymorphism Trp64Arg(C\/T): Results from the Japan Diabetes Prevention Program. J Diabetes Investig 7(3):338\u2013342. https:\/\/doi.org\/10.1111\/jdi.12426","journal-title":"J Diabetes Investig"},{"key":"12178_CR48","doi-asserted-by":"publisher","unstructured":"Cero C, Lea HJ, Zhu KY, Shamsi F, Tseng YH, Cypess AM (2021) \u03b23-Adrenergic receptors regulate human brown\/beige adipocyte lipolysis and thermogenesis. JCI Insight 6(11). https:\/\/doi.org\/10.1172\/jci.insight.139160","DOI":"10.1172\/jci.insight.139160"},{"issue":"1","key":"12178_CR49","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.cmet.2014.12.009","volume":"21","author":"AM Cypess","year":"2015","unstructured":"Cypess AM, Weiner LS, Roberts-Toler C, El\u00eda EF, Kessler SH, Kahn PA, English J, Chatman K, Trauger SA, Doria A (2015) Activation of human brown adipose tissue by a \u03b23-adrenergic receptor agonist. Cell Metabol 21(1):33\u201338","journal-title":"Cell Metabol"},{"issue":"1","key":"12178_CR50","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s40659-019-0226-7","volume":"52","author":"RPA Lima","year":"2019","unstructured":"Lima RPA, Ribeiro MR, de Farias Lima KQ, Sena EA, de Oliveira Costa D, Luna RCP, do Nascimento RAF, da Concei\u00e7\u00e3o Rodrigues Gon\u00e7alves M, de Toledo Vianna RP, de Moraes RM, de Oliveira NFP, de Almeida ATC, de Carvalho Costa MJ (2019) Methylation profile of the ADRB3 gene and its association with lipid profile and nutritional status in adults. Biol Res 52(1):21. https:\/\/doi.org\/10.1186\/s40659-019-0226-7","journal-title":"Biol Res"},{"key":"12178_CR51","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-026-46559-x","author":"LM Diani","year":"2026","unstructured":"Diani LM, Watanabe LM, Noronha NY, da Silva Rodrigues G, de Souza Pinhel MA, Sae-Lee C, de Oliveira BAP, Nicoletti CF, Junqueira GP, Salgado W, Marchini JS, Nonino CB (2026) The epigenetic role of ADRB3 DNA methylation in post-bariatric energy expenditure for women with obesity: a longitudinal observational study. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-026-46559-x","journal-title":"Sci Rep"},{"issue":"4","key":"12178_CR52","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1080\/13813455.2020.1752257","volume":"128","author":"M Mosallaei","year":"2022","unstructured":"Mosallaei M, Ehtesham N, Rahimirad S, Saghi M, Vatandoost N, Khosravi S (2022) PBMCs: a new source of diagnostic and prognostic biomarkers. Arch Physiol Biochem 128(4):1081\u20131087","journal-title":"Arch Physiol Biochem"},{"key":"12178_CR53","doi-asserted-by":"publisher","first-page":"108183","DOI":"10.1016\/j.dib.2022.108183","volume":"42","author":"S-J Baek","year":"2022","unstructured":"Baek S-J, Lee S, Jin H-J (2022) Supplementary data for genome-wide DNA methylation and gene expression analysis of PBMCs in patients with metabolic syndrome. Data Brief 42:108183","journal-title":"Data Brief"},{"issue":"9","key":"12178_CR54","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1080\/15592294.2016.1216284","volume":"11","author":"O Ali","year":"2016","unstructured":"Ali O, Cerjak D, Kent JW Jr, James R, Blangero J, Carless MA, Zhang Y (2016) Methylation of SOCS3 is inversely associated with metabolic syndrome in an epigenome-wide association study of obesity. Epigenetics 11(9):699\u2013707","journal-title":"Epigenetics"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12178-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12178-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12178-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:43:24Z","timestamp":1781876604000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12178-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,19]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12178"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12178-y","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,19]]},"assertion":[{"value":"5 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study received approval from the Ethics Committee of Aja University of Medical Sciences (ID number: IR.AJAUMS.REC.1402.159) and was conducted in compliance with the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"The patients participating in the study provided their informed consent, acknowledging that they understood the nature of the research and voluntarily agreed to participate.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"965"}}