{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:59:36Z","timestamp":1782860376875,"version":"3.54.5"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12194-y","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:19:50Z","timestamp":1782857990000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["PPAR-\u03b3 modulation restores the adiponectin\u2013AMPK\u2013AKT axis to attenuate metabolic stress\u2013associated alzheimer\u2019s pathology"],"prefix":"10.1007","volume":"53","author":[{"given":"Digvijaya","family":"Saini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd.","family":"Mujeeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Akhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Ehtaishamul","family":"Haque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abul Kalam","family":"Najmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"12194_CR1","unstructured":"Kumar A, Sidhu J, Lui F, Tsao JW (2025) Alzheimer Disease. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. Available from: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK499922\/"},{"key":"12194_CR2","doi-asserted-by":"publisher","first-page":"115522","DOI":"10.1016\/j.bcp.2023.115522","volume":"211","author":"AR Monteiro","year":"2023","unstructured":"Monteiro AR, Barbosa DJ, Remi\u00e3o F, Silva R (2023) Alzheimer\u2019s disease: Insights and new prospects in disease pathophysiology, biomarkers and disease-modifying drugs. Biochem Pharmacol 211:115522. https:\/\/doi.org\/10.1016\/j.bcp.2023.115522","journal-title":"Biochem Pharmacol"},{"issue":"7","key":"12194_CR3","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.4239\/wjd.v15","volume":"15","author":"MMI Abdalla","year":"2024","unstructured":"Abdalla MMI (2024) Insulin resistance as the molecular link between diabetes and Alzheimer\u2019s disease. World J Diabetes 15(7):1430\u20131447. https:\/\/doi.org\/10.4239\/wjd.v15","journal-title":"World J Diabetes"},{"issue":"22","key":"12194_CR4","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3390\/ijms252211955","volume":"25","author":"M Kciuk","year":"2024","unstructured":"Kciuk M, Kruczkowska W, Ga\u0142\u0119ziewska J, Wanke K, Ka\u0142uzi\u0144ska-Ko\u0142at \u017b, Aleksandrowicz M et al (2024) Alzheimer\u2019s Disease as Type 3 Diabetes: Understanding the Link and Implications. Int J Mol Sci 25(22):22. https:\/\/doi.org\/10.3390\/ijms252211955","journal-title":"Int J Mol Sci"},{"key":"12194_CR5","doi-asserted-by":"publisher","unstructured":"Berlanga-Acosta J, Guill\u00e9n-Nieto G, Rodr\u00edguez-Rodr\u00edguez N, Bringas-Vega ML, Garc\u00eda-del-Barco-Herrera D, Berlanga-Saez JO et al (2020) Insulin Resistance at the Crossroad of Alzheimer Disease Pathology: A Review. Frontiers in Endocrinology [Internet] 11. Available from: https:\/\/doi.org\/10.3389\/fendo.2020.560375","DOI":"10.3389\/fendo.2020.560375"},{"key":"12194_CR6","doi-asserted-by":"publisher","first-page":"687157","DOI":"10.3389\/fnins","volume":"15","author":"Z Wei","year":"2021","unstructured":"Wei Z, Koya J, Reznik SE (2021) Insulin Resistance Exacerbates Alzheimer Disease via Multiple Mechanisms. Front Neurosci 15:687157. https:\/\/doi.org\/10.3389\/fnins.2021.687157","journal-title":"Front Neurosci"},{"issue":"7","key":"12194_CR7","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1007\/s11011-021-00756","volume":"36","author":"NP Samant","year":"2021","unstructured":"Samant NP, Gupta GL (2021) Adiponectin: a potential target for obesity-associated Alzheimer\u2019s disease. Metab Brain Dis 36(7):1565\u20131572. https:\/\/doi.org\/10.1007\/s11011-021-00756-x","journal-title":"Metab Brain Dis"},{"issue":"17","key":"12194_CR8","doi-asserted-by":"publisher","first-page":"6419","DOI":"10.3390\/ijms21176419","volume":"21","author":"JY Kim","year":"2020","unstructured":"Kim JY, Barua S, Jeong YJ, Lee JE, Adiponectin (2020) The Potential Regulator and Therapeutic Target of Obesity and Alzheimer\u2019s Disease. Int J Mol Sci 21(17):6419. https:\/\/doi.org\/10.3390\/ijms21176419","journal-title":"Int J Mol Sci"},{"key":"12194_CR9","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.nutres.2024.09","volume":"131","author":"KC Racine","year":"2024","unstructured":"Racine KC, Iglesias-Carres L, Herring JA, Wieland KL, Ellsworth PN, Tessem JS et al (2024) The high-fat diet and low-dose streptozotocin type-2 diabetes model induces hyperinsulinemia and insulin resistance in male but not female C57BL\/6J mice. Nutr Res 131:135\u2013146. https:\/\/doi.org\/10.1016\/j.nutres.2024.09.008 PubMed PMID: 39389000","journal-title":"Nutr Res"},{"key":"12194_CR10","doi-asserted-by":"publisher","first-page":"100381","DOI":"10.1016\/j.metop.2025.100381","volume":"27","author":"E Abbasi","year":"2025","unstructured":"Abbasi E, Khodadadi I (2025) High-fat diet may increase the risk of insulin resistance by inducing dysbiosis. Metabol Open 27:100381. https:\/\/doi.org\/10.1016\/j.metop.2025.100381","journal-title":"Metabol Open"},{"issue":"17","key":"12194_CR11","doi-asserted-by":"publisher","first-page":"5481","DOI":"10.3390\/molecules27175481","volume":"27","author":"A Skrzypczak-Wiercioch","year":"2022","unstructured":"Skrzypczak-Wiercioch A, Sa\u0142at K (2022) Lipopolysaccharide-Induced Model of Neuroinflammation: Mechanisms of Action, Research Application and Future Directions for Its Use. Molecules 27(17):5481 https:\/\/doi.org\/10.3390\/molecules27175481","journal-title":"Molecules"},{"key":"12194_CR12","unstructured":"Wharton W (2024) Health Evaluation in African Americans Using RAS Therapy [Clinical trial registration] [Internet]. clinicaltrials.gov. Clinical trial registration no.: NCT02471833. Available from: https:\/\/clinicaltrials.gov\/study\/NCT02471833"},{"issue":"5","key":"12194_CR13","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1002\/alz.12819","volume":"19","author":"P Zhang","year":"2023","unstructured":"Zhang P, Hou Y, Tu W, Campbell N, Pieper AA, Leverenz JB et al (2023) Population-based discovery and Mendelian randomization analysis identify telmisartan as a candidate medicine for Alzheimer\u2019s disease in African Americans. Alzheimers Dement 19(5):1876\u20131887. https:\/\/doi.org\/10.1002\/alz.12819","journal-title":"Alzheimers Dement"},{"issue":"5","key":"12194_CR14","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1007\/s43440-025-00737-2","volume":"77","author":"W Quan","year":"2025","unstructured":"Quan W, Zhang SX, Zhang XY, Chen X, Yang C, Li ZY et al (2025) The application of telmisartan in central nervous system disorders. Pharmacol Rep 77(5):1196\u20131216. https:\/\/doi.org\/10.1007\/s43440-025-00737-2","journal-title":"Pharmacol Rep"},{"key":"12194_CR15","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.biopha.2017.08.041","volume":"95","author":"X Shen","year":"2017","unstructured":"Shen X, Li H, Li W, Wu X, Sun Z, Ding X (2017) Telmisartan ameliorates adipoR1 and adipoR2 expression via PPAR-\u03b3 activation in the coronary artery and VSMCs. Biomed Pharmacother 95:129\u2013136. https:\/\/doi.org\/10.1016\/j.biopha.2017.08.041","journal-title":"Biomed Pharmacother"},{"key":"12194_CR16","doi-asserted-by":"publisher","first-page":"905898","DOI":"10.3389\/fphar","volume":"13","author":"J Tian","year":"2022","unstructured":"Tian J, Wang XQ, Tian Z (2022) Focusing on Formononetin: Recent Perspectives for its Neuroprotective Potentials. Front Pharmacol 13:905898. https:\/\/doi.org\/10.3389\/fphar2022.905898","journal-title":"Front Pharmacol"},{"key":"12194_CR17","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.bbr.2014.03.017","volume":"267","author":"KM Baumgarner","year":"2014","unstructured":"Baumgarner KM, Setti S, Diaz C, Littlefield A, Jones A, Kohman RA (2014) Diet-induced obesity attenuates cytokine production following an immune challenge. Behav Brain Res 267:33\u201341. https:\/\/doi.org\/10.1016\/j.bbr.2014.03.017 PubMed PMID: 24657736; PubMed Central PMCID: PMC4475353","journal-title":"Behav Brain Res"},{"issue":"8","key":"12194_CR18","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1161\/STROKEAHA.110.583948","volume":"41","author":"K Washida","year":"2010","unstructured":"Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M et al (2010) Nonhypotensive dose of telmisartan attenuates cognitive impairment partially due to peroxisome proliferator-activated receptor-\u03b3 activation in mice with chronic cerebral hypoperfusion. Stroke 41(8):1798\u20131806. https:\/\/doi.org\/10.1161\/STROKEAHA.110.583948","journal-title":"Stroke"},{"key":"12194_CR19","doi-asserted-by":"publisher","unstructured":"Fu X, Qin T, Yu J, Jiao J, Ma Z, Fu Q et al (2019) Formononetin Ameliorates Cognitive Disorder via PGC-1\u03b1 Pathway in Neuroinflammation Conditions in High-Fat Diet-Induced Mice. CNS & Neurological Disorders -. Drug Targets 18. https:\/\/doi.org\/10.2174\/1871527318666190807160137","DOI":"10.2174\/1871527318666190807160137"},{"issue":"12","key":"12194_CR20","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1038\/nprot.2013.155","volume":"8","author":"M Leger","year":"2013","unstructured":"Leger M, Quiedeville A, Bouet V, Haelewyn B, Boulouard M, Schumann-Bard P et al (2013) Object recognition test in mice. Nat Protoc 8(12):2531\u20132537. https:\/\/doi.org\/10.1038\/nprot.2013.155","journal-title":"Nat Protoc"},{"issue":"12","key":"12194_CR21","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.5005\/jp-journals-10071-24043","volume":"25","author":"S Sama","year":"2021","unstructured":"Sama S, Jain G, Kant R, Bhadoria AS, Naithani M, Kumar A (2021) Quantifying the Homeostatic Model Assessment of Insulin Resistance to Predict Mortality in Multi-organ Dysfunction Syndrome. Indian J Crit Care Med 25(12):1364\u20131369. https:\/\/doi.org\/10.5005\/jp-journals-10071-24043 PubMed PMID: 35027795; PubMed Central PMCID: PMC8693111","journal-title":"Indian J Crit Care Med"},{"key":"12194_CR22","doi-asserted-by":"publisher","first-page":"653651","DOI":"10.3389\/fnins.2021.653651","volume":"15","author":"A Vinuesa","year":"2021","unstructured":"Vinuesa A, Pomilio C, Gregosa A, Bentivegna M, Presa J, Bellotto M et al (2021) Inflammation and Insulin Resistance as Risk Factors and Potential Therapeutic Targets for Alzheimer\u2019s Disease. Front Neurosci 15:653651. https:\/\/doi.org\/10.3389\/fnins.2021.653651 PubMed PMID: 33967682; PubMed Central PMCID: PMC8102834","journal-title":"Front Neurosci"},{"issue":"12","key":"12194_CR23","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.3390\/antiox12122091","volume":"12","author":"G Martemucci","year":"2023","unstructured":"Martemucci G, Fracchiolla G, Muraglia M, Tardugno R, Dibenedetto RS, D\u2019Alessandro AG (2023) Metabolic Syndrome: A Narrative Review from the Oxidative Stress to the Management of Related Diseases. Antioxid (Basel) 12(12):2091. https:\/\/doi.org\/10.3390\/antiox12122091 PubMed PMID: 38136211; PubMed Central PMCID: PMC10740837","journal-title":"Antioxid (Basel)"},{"issue":"1","key":"12194_CR24","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/s41598-017-18896-5","volume":"8","author":"DA Barri\u00e8re","year":"2018","unstructured":"Barri\u00e8re DA, Noll C, Roussy G, Lizotte F, Kessai A, Kirby K et al (2018) Combination of high-fat\/high-fructose diet and low-dose streptozotocin to model long-term type-2 diabetes complications. Sci Rep 8(1):424. https:\/\/doi.org\/10.1038\/s41598-017-18896-5","journal-title":"Sci Rep"},{"issue":"11","key":"12194_CR25","doi-asserted-by":"publisher","first-page":"3164","DOI":"10.3390\/cells10113164","volume":"10","author":"IJ Malesza","year":"2021","unstructured":"Malesza IJ, Malesza M, Walkowiak J, Mussin N, Walkowiak D, Aringazina R et al (2021) High-Fat, Western-Style Diet, Systemic Inflammation, and Gut Microbiota: A Narrative Review. Cells 10(11):3164. https:\/\/doi.org\/10.3390\/cells10113164 PubMed PMID: 34831387; PubMed Central PMCID: PMC8619527","journal-title":"Cells"},{"issue":"1","key":"12194_CR26","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1007\/s10571-025-01600-x","volume":"45","author":"B Shademan","year":"2025","unstructured":"Shademan B, Yousefi H, Sharafkhani R, Nourazarian A (2025) LPS-Induced Neuroinflammation Disrupts Brain-Derived Neurotrophic Factor and Kinase Pathways in Alzheimer\u2019s Disease Cell Models. Cell Mol Neurobiol 45(1):102. https:\/\/doi.org\/10.1007\/s10571-025-01600-x","journal-title":"Cell Mol Neurobiol"},{"key":"12194_CR27","doi-asserted-by":"publisher","unstructured":"Choe K, Park JS, Park HY, Tahir M, Park TJ, Kim MO (2024) Lupeol protect against LPS-induced neuroinflammation and amyloid beta in adult mouse hippocampus. Front Nutr 11. https:\/\/doi.org\/10.3389\/fnut.2024.1414696","DOI":"10.3389\/fnut.2024.1414696"},{"key":"12194_CR28","doi-asserted-by":"publisher","first-page":"739","DOI":"10.3389\/fphar","volume":"9","author":"MJ Oza","year":"2018","unstructured":"Oza MJ, Kulkarni YA (2018) Formononetin Treatment in Type 2 Diabetic Rats Reduces Insulin Resistance and Hyperglycemia. Front Pharmacol 9:739. https:\/\/doi.org\/10.3389\/fphar2018.00739 PubMed PMID: 30072892; PubMed Central PMCID: PMC6058024","journal-title":"Front Pharmacol"},{"issue":"5","key":"12194_CR29","doi-asserted-by":"publisher","first-page":"182","DOI":"10.37349\/ent.2022.00028","volume":"2","author":"FJC Souza-Junior","year":"2022","unstructured":"Souza-Junior FJC, Cunha LC, Lisboa SF (2022) Toll-like receptor 4 in the interface between neuroimmune response and behavioral alterations caused by stress. Explor Neuroprot Ther 2(5):182\u2013209. https:\/\/doi.org\/10.37349\/ent.2022.00028","journal-title":"Explor Neuroprot Ther"},{"key":"12194_CR30","doi-asserted-by":"publisher","first-page":"560375","DOI":"10.3389\/fendo.2020.560375","volume":"11","author":"J Berlanga-Acosta","year":"2020","unstructured":"Berlanga-Acosta J, Guill\u00e9n-Nieto G, Rodr\u00edguez-Rodr\u00edguez N, Bringas-Vega ML, Garc\u00eda-del-Barco-Herrera D, Berlanga-Saez JO et al (2020) Insulin Resistance at the Crossroad of Alzheimer Disease Pathology: A Review. Front Endocrinol (Lausanne) 11:560375. https:\/\/doi.org\/10.3389\/fendo.2020.560375 PubMed PMID: 33224105; PubMed Central PMCID: PMC7674493","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"8","key":"12194_CR31","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.3390\/biomedicines12081888","volume":"12","author":"F Affuso","year":"2024","unstructured":"Affuso F, Micillo F, Fazio S (2024) Insulin Resistance, a Risk Factor for Alzheimer\u2019s Disease: Pathological Mechanisms and a New Proposal for a Preventive Therapeutic Approach. Biomedicines 12(8):1888. https:\/\/doi.org\/10.3390\/biomedicines12081888","journal-title":"Biomedicines"},{"issue":"1","key":"12194_CR32","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s12017-025-08832-6","volume":"27","author":"EA Alzarea","year":"2025","unstructured":"Alzarea EA, Al-Kuraishy HM, Al-Gareeb AI, Alexiou A, Papadakis M, Beshay ON et al (2025) The Conceivable Role of Metabolic Syndrome in the Pathogenesis of Alzheimer\u2019s Disease: Cellular and Subcellular Alterations in Underpinning a Tale of Two. Neuromolecular Med 27(1):35. https:\/\/doi.org\/10.1007\/s12017-025-08832-6 PubMed PMID: 40379890; PubMed Central PMCID: PMC12084261","journal-title":"Neuromolecular Med"},{"issue":"6","key":"12194_CR33","doi-asserted-by":"publisher","first-page":"940","DOI":"10.3897\/folmed.65.e107259","volume":"65","author":"Cannabidiol improves memory","year":"2023","unstructured":"Cannabidiol improves memory (2023) and decreases IL-1\u03b2 serum levels in rats with lipopolysaccharide-induced inflammation. Folia medica 65(6):940\u2013949. https:\/\/doi.org\/10.3897\/folmed.65.e107259","journal-title":"Folia medica"},{"key":"12194_CR34","doi-asserted-by":"publisher","first-page":"111441","DOI":"10.1016\/j.fct.2020.111441","volume":"142","author":"AM Abo-Youssef","year":"2020","unstructured":"Abo-Youssef AM, Khallaf WA, Khattab MM, Messiha BAS (2020) The anti-Alzheimer effect of telmisartan in a hyperglycemic ovariectomized rat model; role of central angiotensin and estrogen receptors. Food Chem Toxicol 142:111441. https:\/\/doi.org\/10.1016\/j.fct.2020.111441","journal-title":"Food Chem Toxicol"},{"key":"12194_CR35","doi-asserted-by":"publisher","unstructured":"Mahajan DM, Wagh R, Sharma S, Pandit S, Upaganlwar DA, Upasani DC (2024) Pharmacological Assessment Of Formononetin On Behavior, Cognitive Function And Oxidative Stress In Mice. Int J Pharm Sci 02(07). https:\/\/doi.org\/10.5281\/zenodo.12734103. Located at: World","DOI":"10.5281\/zenodo.12734103"},{"key":"12194_CR36","doi-asserted-by":"publisher","first-page":"115174","DOI":"10.1016\/j.bbr.2024.115174","volume":"472","author":"G Bai","year":"2024","unstructured":"Bai G, Ling J, Lu J, Fang M, Yu S (2024) Adiponectin receptor agonist AdipoRon alleviates memory impairment in the hippocampus of septic mice. Behav Brain Res 472:115174. https:\/\/doi.org\/10.1016\/j.bbr.2024.115174","journal-title":"Behav Brain Res"},{"issue":"1","key":"12194_CR37","doi-asserted-by":"publisher","first-page":"8918","DOI":"10.1038\/s41598-019-45509-0","volume":"9","author":"M Wang","year":"2019","unstructured":"Wang M, Jo J, Song J (2019) Adiponectin improves long-term potentiation in the 5XFAD mouse brain. Sci Rep 9(1):8918. https:\/\/doi.org\/10.1038\/s41598-019-45509-0","journal-title":"Sci Rep"},{"key":"12194_CR38","doi-asserted-by":"publisher","first-page":"105876","DOI":"10.1016\/j.nbd.2022.105876","volume":"174","author":"M Khandelwal","year":"2022","unstructured":"Khandelwal M, Manglani K, Upadhyay P, Azad M, Gupta S (2022) AdipoRon induces AMPK activation and ameliorates Alzheimer\u2019s like pathologies and associated cognitive impairment in APP\/PS1 mice. Neurobiol Dis 174:105876. https:\/\/doi.org\/10.1016\/j.nbd.2022.105876 PubMed PMID: 36162737","journal-title":"Neurobiol Dis"},{"key":"12194_CR39","doi-asserted-by":"publisher","unstructured":"Grant WB, Blake SM (2023) Diet\u2019s Role in Modifying Risk of Alzheimer\u2019s Disease: History and Present Understanding. J Alzheimers Dis 96(4):1353\u20131382. https:\/\/doi.org\/10.3233\/JAD-230418","DOI":"10.3233\/JAD-230418"},{"issue":"10","key":"12194_CR40","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.3390\/ph18101527","volume":"18","author":"P Ormazabal","year":"2025","unstructured":"Ormazabal P, Bast\u00edas-P\u00e9rez M, Inestrosa NC, Cisternas P (2025) Adipokines at the Metabolic\u2013Brain Interface: Therapeutic Modulation by Antidiabetic Agents and Natural Compounds in Alzheimer\u2019s Disease. Pharmaceuticals (Basel) 18(10):1527. https:\/\/doi.org\/10.3390\/ph18101527","journal-title":"Pharmaceuticals (Basel)"},{"issue":"17","key":"12194_CR41","doi-asserted-by":"publisher","first-page":"9290","DOI":"10.3390\/ijms22179290","volume":"22","author":"\u0141J Walczak-Nowicka","year":"2021","unstructured":"Walczak-Nowicka \u0141J, Herbet M (2021) Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis. Int J Mol Sci 22(17):9290. https:\/\/doi.org\/10.3390\/ijms22179290","journal-title":"Int J Mol Sci"},{"issue":"1","key":"12194_CR42","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/s40360-025-01021-y","volume":"26","author":"EA Awadalla","year":"2025","unstructured":"Awadalla EA, Mohamed O, Abdelsadik A, Sherkawy HS, Abd El-Kader AEKM (2025) Biochemical, histopathological, and immunohistochemical study on the ameliorative effect of crocin against lipopolysaccharide\u2013induced hippocampal toxicity in male albino rats. BMC Pharmacol Toxicol 26(1):198. https:\/\/doi.org\/10.1186\/s40360-025-01021-y","journal-title":"BMC Pharmacol Toxicol"},{"key":"12194_CR43","doi-asserted-by":"publisher","unstructured":"Kanan DD, Aydemir I, Alizade A, Ebrahimi S, Aksu F, Kanan DD et al (2025 Apr) Investigation of Behavioral Changes and Histopathological Changes in the Brain in Alzheimer\u2019s Modeled Mice with Aluminium Chloride (AlCl3). Cyprus J Med Sci 6. https:\/\/doi.org\/10.4274\/cjms.2024.2024-123","DOI":"10.4274\/cjms.2024.2024-123"},{"issue":"3","key":"12194_CR44","doi-asserted-by":"publisher","first-page":"100166","DOI":"10.1016\/j.jnha.2024.100166","volume":"28","author":"L Sindzingre","year":"2024","unstructured":"Sindzingre L, Bouaziz-Amar E, Mouton-Liger F, Cognat E, Dumurgier J, Vrillon A et al (2024) The role of adiponectin in Alzheimer\u2019s disease: A translational review. J Nutr health aging 28(3):100166. https:\/\/doi.org\/10.1016\/j.jnha.2024.100166","journal-title":"J Nutr health aging"},{"issue":"2","key":"12194_CR45","first-page":"86","volume":"8","author":"LM Wang","year":"2018","unstructured":"Wang LM, Wu Q, Kirk RA, Horn KP, Ebada Salem AH, Hoffman JM et al (2018) Lipopolysaccharide endotoxemia induces amyloid-\u03b2 and p-tau formation in the rat brain. Am J Nucl Med Mol Imaging 8(2):86\u201399 PubMed PMID: 29755842; PubMed Central PMCID: PMC5944824","journal-title":"Am J Nucl Med Mol Imaging"},{"issue":"3","key":"12194_CR46","doi-asserted-by":"publisher","first-page":"919","DOI":"10.3233\/JAD-230133","volume":"94","author":"XX Fu","year":"2023","unstructured":"Fu XX, Wei B, Cao HM, Duan R, Deng Y, Lian HW et al (2023) Telmisartan Alleviates Alzheimer\u2019s Disease-Related Neuropathologies and Cognitive Impairments. J Alzheimer\u2019s Disease 94(3):919\u2013933. https:\/\/doi.org\/10.3233\/JAD-230133","journal-title":"J Alzheimer\u2019s Disease"},{"issue":"4","key":"12194_CR47","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s13205-021-02738-3","volume":"11","author":"M Zheng","year":"2021","unstructured":"Zheng M, Wang P (2021) Role of insulin receptor substance-1 modulating PI3K\/Akt insulin signaling pathway in Alzheimer\u2019s disease. 3 Biotech 11(4):179. https:\/\/doi.org\/10.1007\/s13205-021-02738-3 PubMed PMID: 33927970; PubMed Central PMCID: PMC7981362","journal-title":"3 Biotech"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12194-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12194-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12194-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:19:57Z","timestamp":1782857997000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12194-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12194"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12194-y","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]},"assertion":[{"value":"20 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All procedures were undertaken in compliance with rules of the \u201cCommittee for Control and Supervision of Experiments on Animals\u201d (CPCSEA). Study protocol was reviewed and approved by Institutional Animal Ethical Committee (IAEC), Jamia Hamdard, New Delhi (Protocol No. 2080, dated 14\/09\/2023).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"1037"}}