{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T03:52:38Z","timestamp":1784865158935,"version":"3.55.0"},"reference-count":99,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82371203"],"award-info":[{"award-number":["82371203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82371194"],"award-info":[{"award-number":["82371194"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"crossref","award":["CSTB2024NSCQ-QCXMX0004 and 2022NSCQ-LZX0010"],"award-info":[{"award-number":["CSTB2024NSCQ-QCXMX0004 and 2022NSCQ-LZX0010"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12213-y","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T12:21:55Z","timestamp":1782562915000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["HDAC3 in Alzheimer\u2019s Disease: established evidence, unresolved questions, and translational priorities"],"prefix":"10.1007","volume":"53","author":[{"given":"Jieren","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiqiong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,27]]},"reference":[{"key":"12213_CR1","doi-asserted-by":"crossref","unstructured":"Liu RM, Aging (2022) Cellular Senescence, and Alzheimer\u2019s Disease. INT J MOL SCI 23","DOI":"10.3390\/ijms23041989"},{"key":"12213_CR2","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1093\/procel\/pwae026","volume":"16","author":"Q Zheng","year":"2025","unstructured":"Zheng Q, Wang X (2025) Alzheimer\u2019s disease: insights into pathology, molecular mechanisms, and therapy. PROTEIN CELL 16:83","journal-title":"PROTEIN CELL"},{"key":"12213_CR3","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.molcel.2020.08.015","volume":"80","author":"Z Chi","year":"2020","unstructured":"Chi Z et al (2020) Deacetylase 3 Couples Mitochondria to Drive IL-1\u03b2-Dependent Inflammation by Configuring Fatty Acid Oxidation. MOL CELL 80:43","journal-title":"MOL CELL"},{"key":"12213_CR4","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/s12031-025-02363-2","volume":"75","author":"P Tiwari","year":"2025","unstructured":"Tiwari P, Dwivedi R, Kaushik M, Tripathi M, Dada R (2025) Genetics and Epigenetics of Alzheimer\u2019s Disease: Understanding Pathogenesis and Exploring Therapeutic Potential. J Mol neuroscience: MN 75:72","journal-title":"J Mol neuroscience: MN"},{"key":"12213_CR5","first-page":"a18713","volume":"6","author":"E Seto","year":"2014","unstructured":"Seto E, Yoshida M (2014) Erasers of histone acetylation: the histone deacetylase enzymes. CSH PERSPECT BIOL 6:a18713","journal-title":"CSH PERSPECT BIOL"},{"key":"12213_CR6","doi-asserted-by":"publisher","first-page":"9447","DOI":"10.1074\/jbc.M105993200","volume":"277","author":"WM Yang","year":"2002","unstructured":"Yang WM, Tsai SC, Wen YD, Fejer G, Seto E (2002) Functional domains of histone deacetylase-3. J BIOL CHEM 277:9447","journal-title":"J BIOL CHEM"},{"key":"12213_CR7","doi-asserted-by":"publisher","first-page":"782375","DOI":"10.3389\/fnmol.2021.782375","volume":"14","author":"D Nakatsuka","year":"2021","unstructured":"Nakatsuka D et al (2021) Deacetylase 2 Knockdown Ameliorates Morphological Abnormalities of Dendritic Branches and Spines to Improve Synaptic Plasticity in an APP\/PS1 Transgenic Mouse Model. FRONT MOL NEUROSCI 14:782375","journal-title":"FRONT MOL NEUROSCI"},{"key":"12213_CR8","doi-asserted-by":"publisher","first-page":"119275","DOI":"10.1016\/j.bbamcr.2022.119275","volume":"1869","author":"T Qureshi","year":"2022","unstructured":"Qureshi T, Chinnathambi S (2022) Histone deacetylase-6 modulates Tau function in Alzheimer\u2019s disease. Biochim et Biophys acta Mol cell Res 1869:119275","journal-title":"Biochim et Biophys acta Mol cell Res"},{"key":"12213_CR9","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1007\/s12031-014-0460-y","volume":"55","author":"J Leyk","year":"2015","unstructured":"Leyk J, Goldbaum O, Noack M, Richter-Landsberg C (2015) Inhibition of HDAC6 modifies tau inclusion body formation and impairs autophagic clearance. J Mol neuroscience: MN 55:1031","journal-title":"J Mol neuroscience: MN"},{"key":"12213_CR10","doi-asserted-by":"publisher","first-page":"2771","DOI":"10.1111\/febs.15895","volume":"289","author":"Y N\u00fa Ez-\u00e1lvarez","year":"2022","unstructured":"N\u00fa Ez-\u00e1lvarez Y, Suelves M (2022) HDAC11: a multifaceted histone deacetylase with proficient fatty deacylase activity and its roles in physiological processes. FEBS J 289:2771","journal-title":"FEBS J"},{"key":"12213_CR11","doi-asserted-by":"publisher","first-page":"5439","DOI":"10.1038\/sj.onc.1210612","volume":"26","author":"P Karagianni","year":"2007","unstructured":"Karagianni P, Wong J (2007) HDAC3: taking the SMRT-N-CoRrect road to repression. ONCOGENE 26:5439","journal-title":"ONCOGENE"},{"key":"12213_CR12","doi-asserted-by":"publisher","first-page":"7202","DOI":"10.1073\/pnas.97.13.7202","volume":"97","author":"YD Wen","year":"2000","unstructured":"Wen YD et al (2000) The histone deacetylase-3 complex contains nuclear receptor corepressors. Proceedings of the National Academy of Sciences 97:7202","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"12213_CR13","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1038\/s41593-018-0253-7","volume":"21","author":"SJ Marzi","year":"2018","unstructured":"Marzi SJ et al (2018) A histone acetylome-wide association study of Alzheimer\u2019s disease identifies disease-associated H3K27ac differences in the entorhinal cortex. NAT NEUROSCI 21:1618","journal-title":"NAT NEUROSCI"},{"key":"12213_CR14","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1523\/JNEUROSCI.5704-10.2011","volume":"31","author":"FH Bardai","year":"2011","unstructured":"Bardai FH, D\u2019Mello SR (2011) Selective toxicity by HDAC3 in neurons: regulation by Akt and GSK3beta. J NEUROSCI 31:1746","journal-title":"J NEUROSCI"},{"key":"12213_CR15","doi-asserted-by":"publisher","first-page":"235","DOI":"10.2174\/156802609788085304","volume":"9","author":"R Ficner","year":"2009","unstructured":"Ficner R (2009) Novel structural insights into class I and II histone deacetylases. Current Topics in Medicinal Chemistry 9:235","journal-title":"Current Topics in Medicinal Chemistry"},{"key":"12213_CR16","doi-asserted-by":"crossref","unstructured":"Davis N et al (2024) Histone deacetylase-3 regulates the expression of the amyloid precursor protein and its inhibition promotes neuroregenerative pathways in Alzheimer\u2019s disease models. FASEB journal: official publication of the Federation of American Societies for Experimental Biology 38 e23659","DOI":"10.1096\/fj.202301762RR"},{"key":"12213_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126592","author":"KW Anderson","year":"2015","unstructured":"Anderson KW et al (2015) Quantification of histone deacetylase isoforms in human frontal cortex, human retina, and mouse brain. PLOS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0126592","journal-title":"PLOS ONE"},{"key":"12213_CR18","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1111\/acel.12642","volume":"16","author":"X Zhu","year":"2017","unstructured":"Zhu X et al (2017) HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer\u2019s disease. AGING CELL 16:1073","journal-title":"AGING CELL"},{"key":"12213_CR19","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1038\/npp.2016.274","volume":"42","author":"JL Kwapis","year":"2017","unstructured":"Kwapis JL et al (2017) Context and Auditory Fear are Differentially Regulated by HDAC3 Activity in the Lateral and Basal Subnuclei of the Amygdala. Neuropsychopharmacology: official publication Am Coll Neuropsychopharmacol 42:1284","journal-title":"Neuropsychopharmacology: official publication Am Coll Neuropsychopharmacol"},{"key":"12213_CR20","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.biopsych.2018.01.025","volume":"84","author":"M Malvaez","year":"2018","unstructured":"Malvaez M et al (2018) Habits Are Negatively Regulated by Histone Deacetylase 3 in the Dorsal Striatum. BIOL PSYCHIAT 84:383","journal-title":"BIOL PSYCHIAT"},{"key":"12213_CR21","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.euroneuro.2020.01.015","volume":"33","author":"E Schueller","year":"2020","unstructured":"Schueller E et al (2020) Dysregulation of histone acetylation pathways in hippocampus and frontal cortex of Alzheimer\u2019s disease patients. Eur neuropsychopharmacology: J Eur Coll Neuropsychopharmacol 33:101","journal-title":"Eur neuropsychopharmacology: J Eur Coll Neuropsychopharmacol"},{"key":"12213_CR22","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3233\/JAD-171032","volume":"62","author":"L Mahady","year":"2018","unstructured":"Mahady L et al (2018) Frontal Cortex Epigenetic Dysregulation During the Progression of Alzheimer\u2019s Disease. J Alzheimer\u2019s disease: JAD 62:115","journal-title":"J Alzheimer\u2019s disease: JAD"},{"key":"12213_CR23","doi-asserted-by":"crossref","unstructured":"Bai P et al (2025) HDAC11 displays neuropathological alterations and offers as a novel drug target for Alzheimer\u2019s disease. Alzheimer\u2019s & dementia: the journal of the Alzheimer\u2019s Association 21 e14616","DOI":"10.1002\/alz.14616"},{"key":"12213_CR24","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.1038\/s41467-020-16361-y","volume":"11","author":"P Pao","year":"2020","unstructured":"Pao P et al (2020) HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer\u2019s disease. NAT COMMUN 11:2484","journal-title":"NAT COMMUN"},{"key":"12213_CR25","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1002\/(SICI)1521-1878(199808)20:8<615::AID-BIES4>3.0.CO;2-H","volume":"20","author":"MH Kuo","year":"1998","unstructured":"Kuo MH, Allis CD (1998) Roles of histone acetyltransferases and deacetylases in gene regulation. BioEssays 20:615","journal-title":"BioEssays"},{"key":"12213_CR26","doi-asserted-by":"publisher","first-page":"880267","DOI":"10.3389\/fncel.2022.880267","volume":"16","author":"S Hung","year":"2022","unstructured":"Hung S et al (2022) Electroacupuncture improves TBI dysfunction by targeting HDAC overexpression and BDNF-associated Akt\/GSK-3\u03b2 signaling. FRONT CELL NEUROSCI 16:880267","journal-title":"FRONT CELL NEUROSCI"},{"key":"12213_CR27","doi-asserted-by":"publisher","first-page":"616642","DOI":"10.3389\/fnmol.2021.616642","volume":"14","author":"P Main","year":"2021","unstructured":"Main P, Tan WJ, Wheeler D, Fitzsimons HL (2021) Increased Abundance of Nuclear HDAC4 Impairs Neuronal Development and Long-Term Memory. FRONT MOL NEUROSCI 14:616642","journal-title":"FRONT MOL NEUROSCI"},{"key":"12213_CR28","doi-asserted-by":"crossref","unstructured":"Huang C et al (2022) HDAC4 Inhibitors as Antivascular Senescence Therapeutics. OXID MED CELL LONGEV 3087916 (2022)","DOI":"10.1155\/2022\/3087916"},{"key":"12213_CR29","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.nlm.2015.06.006","volume":"123","author":"HL Fitzsimons","year":"2015","unstructured":"Fitzsimons HL (2015) The Class IIa histone deacetylase HDAC4 and neuronal function: Nuclear nuisance and cytoplasmic stalwart? Neurobiol Learn Mem 123:149","journal-title":"Neurobiol Learn Mem"},{"key":"12213_CR30","doi-asserted-by":"publisher","first-page":"7538","DOI":"10.1523\/JNEUROSCI.0260-15.2015","volume":"35","author":"A Sen","year":"2015","unstructured":"Sen A, Nelson TJ, Alkon DL (2015) ApoE4 and A\u03b2 Oligomers Reduce BDNF Expression via HDAC Nuclear Translocation. J Neurosci 35:7538","journal-title":"J Neurosci"},{"issue":"1","key":"12213_CR31","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3233\/JAD-2012-121009","volume":"33","author":"RC Agis-Balboa","year":"2012","unstructured":"Agis-Balboa RC, Pavelka Z, Kerimoglu C, Fischer A (2012) Loss of HDAC5 impairs memory function: implications for Alzheimer\u2019s disease. J Alzheimers Dis 33(1):35","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"12213_CR32","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13024-025-00796-2","volume":"20","author":"J Ye","year":"2025","unstructured":"Ye J et al (2025) Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis. Mol Neurodegener 20:5","journal-title":"Mol Neurodegener"},{"key":"12213_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-026-03556-w","author":"Y Lei","year":"2026","unstructured":"Lei Y et al (2026) Neuronal HDAC9: a key regulator of cognitive and synaptic aging, rescuing Alzheimer\u2019s disease-related phenotypes. Molecular Psychiatry. https:\/\/doi.org\/10.1038\/s41380-026-03556-w","journal-title":"Molecular Psychiatry"},{"key":"12213_CR34","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1007\/s12264-019-00361-0","volume":"35","author":"Y Lu","year":"2019","unstructured":"Lu Y, Tan L, Wang X (2019) Circular HDAC9\/microRNA-138\/Sirtuin-1 Pathway Mediates Synaptic and Amyloid Precursor Protein Processing Deficits in Alzheimer\u2019s Disease. Neurosci Bull 35:877","journal-title":"Neurosci Bull"},{"key":"12213_CR35","unstructured":"Research Paper Histone Deacetylase Class IIb Inhibition Improves Amyloid- \u03b2 -induced Learning and Memory Deficits in Male Rats"},{"key":"12213_CR36","unstructured":"Inhibition of CGRP receptor ameliorates AD pathology by reprogramming lipid metabolism through HDAC11\/LXR \u03b2 \/ABCA1 signaling AUTHOR LIST"},{"key":"12213_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115312","volume":"166","author":"SY Baek","year":"2023","unstructured":"Baek SY et al (2023) Development of a novel histone deacetylase inhibitor unveils the role of HDAC11 in alleviating depression by inhibition of microglial activation. Biomed Pharmacother 166:115312","journal-title":"Biomed Pharmacother"},{"key":"12213_CR38","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/S0092-8674(00)80211-1","volume":"89","author":"MJ Pazin","year":"1997","unstructured":"Pazin MJ, Kadonaga JT (1997) What\u2019s up and down with histone deacetylation and transcription. CELL 89:325","journal-title":"CELL"},{"key":"12213_CR39","doi-asserted-by":"publisher","first-page":"3131","DOI":"10.1242\/dev.037127","volume":"136","author":"F Tie","year":"2009","unstructured":"Tie F et al (2009) CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing. Development 136:3131","journal-title":"Development"},{"issue":"1","key":"12213_CR40","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1186\/s13148-021-01126-1","volume":"13","author":"TH Beacon","year":"2021","unstructured":"Beacon TH et al (2021) The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes. Clin Epigenetics 13:138","journal-title":"Clin Epigenetics"},{"key":"12213_CR41","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s40478-023-01696-6","volume":"12","author":"DC Xu","year":"2024","unstructured":"Xu DC et al (2024) Histone acetylation in an Alzheimer\u2019s disease cell model promotes homeostatic amyloid-reducing pathways. ACTA NEUROPATHOL COM 12:3","journal-title":"ACTA NEUROPATHOL COM"},{"key":"12213_CR42","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1111\/acel.12642","volume":"16","author":"X Zhu","year":"2017","unstructured":"Zhu X et al (2017) HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer\u2019s disease. Aging Cell 16:1073","journal-title":"Aging Cell"},{"key":"12213_CR43","first-page":"118664","volume":"1867","author":"E Lauretti","year":"2020","unstructured":"Lauretti E, Dincer O, Pratico D (2020) Glycogen synthase kinase-3 signaling in Alzheimer\u2019s disease. BBA-MOL CELL RES 1867:118664","journal-title":"BBA-MOL CELL RES"},{"key":"12213_CR44","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1097\/ALN.0000000000000278","volume":"121","author":"G Tao","year":"2014","unstructured":"Tao G et al (2014) Sevoflurane induces tau phosphorylation and glycogen synthase kinase 3beta activation in young mice. Anesthesiology 121:510","journal-title":"Anesthesiology"},{"key":"12213_CR45","doi-asserted-by":"publisher","first-page":"8641","DOI":"10.1038\/s41598-017-08535-4","volume":"7","author":"T Kuboyama","year":"2017","unstructured":"Kuboyama T et al (2017) HDAC3 inhibition ameliorates spinal cord injury by immunomodulation. SCI REP-UK 7:8641","journal-title":"SCI REP-UK"},{"key":"12213_CR46","doi-asserted-by":"publisher","first-page":"eade6900","DOI":"10.1126\/sciadv.ade6900","volume":"10","author":"Y Zhang","year":"2024","unstructured":"Zhang Y et al (2024) Arresting the bad seed: HDAC3 regulates proliferation of different microglia after ischemic stroke. SCI ADV 10:eade6900","journal-title":"SCI ADV"},{"key":"12213_CR47","doi-asserted-by":"publisher","first-page":"6237351","DOI":"10.1155\/2017\/6237351","volume":"2017","author":"M Xia","year":"2017","unstructured":"Xia M et al (2017) Proteomic Analysis of HDAC3 Selective Inhibitor in the Regulation of Inflammatory Response of Primary Microglia. NEURAL PLAST 2017:6237351","journal-title":"NEURAL PLAST"},{"key":"12213_CR48","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.molcel.2020.08.015","volume":"80","author":"Z Chi","year":"2020","unstructured":"Chi Z et al (2020) Deacetylase 3 Couples Mitochondria to Drive IL-1beta-Dependent Inflammation by Configuring Fatty Acid Oxidation. MOL CELL 80:43","journal-title":"MOL CELL"},{"key":"12213_CR49","doi-asserted-by":"publisher","first-page":"e18160","DOI":"10.1016\/j.heliyon.2023.e18160","volume":"9","author":"H Gu","year":"2023","unstructured":"Gu H et al (2023) RGFP966 exerts neuroprotective effect via HDAC3\/Nrf2 pathway after surgical brain injury in rats. HELIYON 9:e18160","journal-title":"HELIYON"},{"key":"12213_CR50","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/s11658-024-00634-1","volume":"29","author":"Y Chen","year":"2024","unstructured":"Chen Y et al (2024) Pterostilbene improves neurological dysfunction and neuroinflammation after ischaemic stroke via HDAC3\/Nrf1-mediated microglial activation. CELL MOL BIOL LETT 29:114","journal-title":"CELL MOL BIOL LETT"},{"key":"12213_CR51","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s12974-018-1193-6","volume":"15","author":"S Chen","year":"2018","unstructured":"Chen S et al (2018) Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-kappaB pathway dependent of HDAC3. J NEUROINFLAMM 15:150","journal-title":"J NEUROINFLAMM"},{"key":"12213_CR52","doi-asserted-by":"publisher","first-page":"109633","DOI":"10.1016\/j.neuropharm.2023.109633","volume":"237","author":"Y Li","year":"2023","unstructured":"Li Y et al (2023) HDAC3 inhibitor (BRD3308) modulates microglial pyroptosis and neuroinflammation through PPARgamma\/NLRP3\/GSDMD to improve neurological function after intraventricular hemorrhage in mice. Neuropharmacology 237:109633","journal-title":"Neuropharmacology"},{"key":"12213_CR53","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/s41593-024-01580-z","volume":"27","author":"B Clayton","year":"2024","unstructured":"Clayton B et al (2024) A phenotypic screening platform for identifying chemical modulators of astrocyte reactivity. NAT NEUROSCI 27:656","journal-title":"NAT NEUROSCI"},{"key":"12213_CR54","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29235744","volume":"29","author":"N Puranik","year":"2024","unstructured":"Puranik N, Song M (2024) Glutamate: molecular mechanisms and signaling pathway in Alzheimer\u2019s disease, a potential therapeutic target. Molecules 29:5744","journal-title":"Molecules"},{"key":"12213_CR55","doi-asserted-by":"publisher","first-page":"107559","DOI":"10.1016\/j.neuropharm.2019.03.002","volume":"161","author":"E Pajarillo","year":"2019","unstructured":"Pajarillo E, Rizor A, Lee J, Aschner M, Lee E (2019) The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: potential targets for neurotherapeutics. NEUROPHARMACOLOGY 161:107559","journal-title":"NEUROPHARMACOLOGY"},{"key":"12213_CR56","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2024.1429880","volume":"17","author":"CW Smies","year":"2024","unstructured":"Smies CW et al (2024) Pharmacological HDAC3 inhibition alters memory updating in young and old male mice. Frontiers in Molecular Neuroscience 17:1429880","journal-title":"Frontiers in Molecular Neuroscience"},{"issue":"29","key":"12213_CR57","doi-asserted-by":"publisher","first-page":"e1619242025","DOI":"10.1523\/jneurosci.1619-24.2025","volume":"45","author":"AC Rodriguez","year":"2025","unstructured":"Rodriguez AC et al (2025) HDAC3 serine 424 phospho-mimic and phospho-null mutants bidirectionally modulate long-term memory formation and synaptic plasticity in the adult and aging mouse brain. The Journal of Neuroscience 45:e1619242025","journal-title":"The Journal of Neuroscience"},{"key":"12213_CR58","doi-asserted-by":"publisher","first-page":"107367","DOI":"10.1016\/j.nlm.2020.107367","volume":"178","author":"AA Keiser","year":"2021","unstructured":"Keiser AA et al (2021) Systemic HDAC3 inhibition ameliorates impairments in synaptic plasticity caused by simulated galactic cosmic radiation exposure in male mice. NEUROBIOL LEARN MEM 178:107367","journal-title":"NEUROBIOL LEARN MEM"},{"key":"12213_CR59","doi-asserted-by":"publisher","first-page":"16616","DOI":"10.1038\/srep16616","volume":"5","author":"M Sharma","year":"2015","unstructured":"Sharma M, Shetty MS, Arumugam TV, Sajikumar S (2015) Histone deacetylase 3 inhibition re-establishes synaptic tagging and capture in aging through the activation of nuclear factor kappa B. SCI REP-UK 5:16616","journal-title":"SCI REP-UK"},{"key":"12213_CR60","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12868-019-0546-0","volume":"20","author":"STA Louis","year":"2019","unstructured":"Louis STA, Sharma D, Kim MS, D\u2019Mello SR (2019) The Bdnf and Npas4 genes are targets of HDAC3-mediated transcriptional repression. BMC NEUROSCI 20:65","journal-title":"BMC NEUROSCI"},{"key":"12213_CR61","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.nbd.2013.11.005","volume":"63","author":"R Koldamova","year":"2014","unstructured":"Koldamova R et al (2014) Genome-wide approaches reveal EGR1-controlled regulatory networks associated with neurodegeneration. NEUROBIOL DIS 63:107","journal-title":"NEUROBIOL DIS"},{"key":"12213_CR62","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3389\/fnsys.2017.00065","volume":"11","author":"ML Phan","year":"2017","unstructured":"Phan ML et al (2017) HDAC3 Inhibitor RGFP966 Modulates Neuronal Memory for Vocal Communication Signals in a Songbird Model. FRONT SYST NEUROSCI 11:65","journal-title":"FRONT SYST NEUROSCI"},{"key":"12213_CR63","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1124\/jpet.114.219345","volume":"352","author":"L Formisano","year":"2015","unstructured":"Formisano L et al (2015) MS-275 inhibits aroclor 1254-induced SH-SY5Y neuronal cell toxicity by preventing the formation of the HDAC3\/REST complex on the synapsin-1 promoter. J PHARMACOL EXP THER 352:236","journal-title":"J PHARMACOL EXP THER"},{"key":"12213_CR64","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1523\/JNEUROSCI.5052-10.2011","volume":"31","author":"SC McQuown","year":"2011","unstructured":"McQuown SC et al (2011) HDAC3 is a critical negative regulator of long-term memory formation. J neuroscience: official J Soc Neurosci 31:764","journal-title":"J neuroscience: official J Soc Neurosci"},{"key":"12213_CR65","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.1128\/MCB.24.6.2364-2372.2004","volume":"24","author":"M Vermeulen","year":"2004","unstructured":"Vermeulen M et al (2004) In vitro targeting reveals intrinsic histone tail specificity of the Sin3\/histone deacetylase and N-CoR\/SMRT corepressor complexes. MOL CELL BIOL 24:2364","journal-title":"MOL CELL BIOL"},{"key":"12213_CR66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4068\/cmj.2016.52.1.1","volume":"52","author":"S Yoon","year":"2016","unstructured":"Yoon S, Eom GH (2016) HDAC and HDAC Inhibitor: From Cancer to Cardiovascular Diseases. Chonnam Med J 52:1","journal-title":"Chonnam Med J"},{"key":"12213_CR67","doi-asserted-by":"publisher","first-page":"9573","DOI":"10.1007\/s12035-025-04866-w","volume":"62","author":"Y Li","year":"2025","unstructured":"Li Y, Izhar T, Kanekiyo T (2025) HDAC3 as an Emerging Therapeutic Target for Alzheimer\u2019s Disease and other Neurological Disorders. MOL NEUROBIOL 62:9573","journal-title":"MOL NEUROBIOL"},{"key":"12213_CR68","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1038\/npp.2009.197","volume":"35","author":"M Kilgore","year":"2010","unstructured":"Kilgore M et al (2010) Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer\u2019s disease. NEUROPSYCHOPHARMACOL 35:870","journal-title":"NEUROPSYCHOPHARMACOL"},{"key":"12213_CR69","doi-asserted-by":"publisher","first-page":"5076","DOI":"10.2174\/1381612811319280006","volume":"19","author":"M Cuadrado-Tejedor","year":"2013","unstructured":"Cuadrado-Tejedor M, Ricobaraza AL, Torrijo R, Franco R, Garcia-Osta A (2013) Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer\u2032s disease-like phenotype of a commonly used mouse model. CURR PHARM Des 19:5076","journal-title":"CURR PHARM Des"},{"key":"12213_CR70","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1038\/s41419-021-04019-6","volume":"12","author":"L Ning","year":"2021","unstructured":"Ning L, Rui X, Bo W, Qing G (2021) The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury. CELL DEATH DIS 12:734","journal-title":"CELL DEATH DIS"},{"key":"12213_CR71","doi-asserted-by":"publisher","first-page":"2647","DOI":"10.1073\/pnas.1213364110","volume":"110","author":"M Malvaez","year":"2013","unstructured":"Malvaez M et al (2013) HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner. P NATL ACAD SCI USA 110:2647","journal-title":"P NATL ACAD SCI USA"},{"key":"12213_CR72","doi-asserted-by":"publisher","first-page":"783","DOI":"10.3233\/JAD-150838","volume":"51","author":"K Krishna","year":"2016","unstructured":"Krishna K, Behnisch T, Sajikumar S (2016) Inhibition of Histone Deacetylase 3 Restores Amyloid-beta Oligomer-Induced Plasticity Deficit in Hippocampal CA1 Pyramidal Neurons. J ALZHEIMERS DIS 51:783","journal-title":"J ALZHEIMERS DIS"},{"key":"12213_CR73","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1021\/acschembio.5b00640","volume":"11","author":"FF Wagner","year":"2016","unstructured":"Wagner FF et al (2016) An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in beta-Cell Protection. ACS CHEM BIOL 11:363","journal-title":"ACS CHEM BIOL"},{"key":"12213_CR74","doi-asserted-by":"publisher","first-page":"8827","DOI":"10.1021\/acs.jmedchem.0c01676","volume":"64","author":"N Adhikari","year":"2021","unstructured":"Adhikari N, Jha T, Ghosh B (2021) Dissecting Histone Deacetylase 3 in Multiple Disease Conditions: Selective Inhibition as a Promising Therapeutic Strategy. J MED CHEM 64:8827","journal-title":"J MED CHEM"},{"key":"12213_CR75","doi-asserted-by":"publisher","first-page":"8827","DOI":"10.1021\/acs.jmedchem.0c01676","volume":"64","author":"N Adhikari","year":"2021","unstructured":"Adhikari N, Jha T, Ghosh B (2021) Dissecting Histone Deacetylase 3 in Multiple Disease Conditions: Selective Inhibition as a Promising Therapeutic Strategy. J MED CHEM 64:8827","journal-title":"J MED CHEM"},{"key":"12213_CR76","doi-asserted-by":"publisher","first-page":"116696","DOI":"10.1016\/j.ejmech.2024.116696","volume":"276","author":"Z Huang","year":"2024","unstructured":"Huang Z, Zeng L, Cheng B, Li D (2024) Overview of class I HDAC modulators: Inhibitors and degraders. EUR J MED CHEM 276:116696","journal-title":"EUR J MED CHEM"},{"key":"12213_CR77","doi-asserted-by":"publisher","first-page":"4008","DOI":"10.1016\/j.bmc.2016.06.040","volume":"24","author":"FF Wagner","year":"2016","unstructured":"Wagner FF et al (2016) Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. BIOORGAN MED CHEM 24:4008","journal-title":"BIOORGAN MED CHEM"},{"key":"12213_CR78","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1177\/13872877251352107","volume":"106","author":"C Bose","year":"2025","unstructured":"Bose C et al (2025) Low-dose dietary vorinostat increases brain histone acetylation levels and reduces oxidative stress in an Alzheimer\u2019s disease mouse model. J Alzheimer\u2019s disease: JAD 106:1360","journal-title":"J Alzheimer\u2019s disease: JAD"},{"key":"12213_CR79","doi-asserted-by":"publisher","first-page":"13124","DOI":"10.1523\/JNEUROSCI.0914-15.2015","volume":"35","author":"KM Bieszczad","year":"2015","unstructured":"Bieszczad KM et al (2015) Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation. J neuroscience: official J Soc Neurosci 35:13124","journal-title":"J neuroscience: official J Soc Neurosci"},{"key":"12213_CR80","doi-asserted-by":"publisher","first-page":"109633","DOI":"10.1016\/j.neuropharm.2023.109633","volume":"237","author":"Y Li","year":"2023","unstructured":"Li Y et al (2023) HDAC3 inhibitor (BRD3308) modulates microglial pyroptosis and neuroinflammation through PPAR\u03b3\/NLRP3\/GSDMD to improve neurological function after intraventricular hemorrhage in mice. Neuropharmacology 237:109633","journal-title":"Neuropharmacology"},{"key":"12213_CR81","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1089\/jop.2017.0059","volume":"34","author":"HM Schmitt","year":"2018","unstructured":"Schmitt HM, Schlamp CL, Nickells RW (2018) Targeting HDAC3 Activity with RGFP966 Protects Against Retinal Ganglion Cell Nuclear Atrophy and Apoptosis After Optic Nerve Injury. J ocular Pharmacol therapeutics: official J Association Ocular Pharmacol Ther 34:260","journal-title":"J ocular Pharmacol therapeutics: official J Association Ocular Pharmacol Ther"},{"key":"12213_CR82","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1111\/dom.12470","volume":"17","author":"M Lundh","year":"2015","unstructured":"Lundh M, Galbo T, Poulsen SS, Mandrup-Poulsen T (2015) Histone deacetylase 3 inhibition improves glycaemia and insulin secretion in obese diabetic rats. Diabetes Obes Metab 17:703","journal-title":"Diabetes Obes Metab"},{"key":"12213_CR83","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1021\/acschemneuro.0c00721","volume":"3","author":"S Pulya","year":"2021","unstructured":"Pulya S et al (2021) A Novel Benzamide Class Histone Deacetylase 3 Inhibitor Improves Learning and Memory in Novel Object Recognition Mouse Model. ACS CHEM NEUROSCI PT 3:12 883","journal-title":"ACS CHEM NEUROSCI"},{"key":"12213_CR84","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/s41568-021-00365-x","volume":"21","author":"B Dale","year":"2021","unstructured":"Dale B et al (2021) Advancing targeted protein degradation for cancer therapy. NAT REV CANCER 21:638","journal-title":"NAT REV CANCER"},{"key":"12213_CR85","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/s41568-021-00365-x","volume":"21","author":"B Dale","year":"2021","unstructured":"Dale B et al (2021) Advancing targeted protein degradation for cancer therapy. Nat Rev Cancer 21:638","journal-title":"Nat Rev Cancer"},{"key":"12213_CR86","doi-asserted-by":"publisher","first-page":"103395","DOI":"10.1016\/j.drudis.2022.103395","volume":"28","author":"N Guedeney","year":"2023","unstructured":"Guedeney N, Cornu M, Schwalen F, Kieffer C, Voisin-Chiret AS (2023) PROTAC technology: A new drug design for chemical biology with many challenges in drug discovery. DRUG DISCOV TODAY 28:103395","journal-title":"DRUG DISCOV TODAY"},{"key":"12213_CR87","doi-asserted-by":"publisher","first-page":"6092","DOI":"10.1021\/ja311795d","volume":"135","author":"EJ Douglass","year":"2013","unstructured":"Douglass EJ, Miller CJ, Sparer G, Shapiro H, Spiegel DA (2013) A comprehensive mathematical model for three-body binding equilibria. J AM CHEM SOC 135:6092","journal-title":"J AM CHEM SOC"},{"key":"12213_CR88","doi-asserted-by":"publisher","first-page":"112800","DOI":"10.1016\/j.ejmech.2020.112800","volume":"208","author":"F Cao","year":"2020","unstructured":"Cao F et al (2020) Induced protein degradation of histone deacetylases 3 (HDAC3) by proteolysis targeting chimera (PROTAC). EUR J MED CHEM 208:112800","journal-title":"EUR J MED CHEM"},{"key":"12213_CR89","doi-asserted-by":"publisher","first-page":"9866","DOI":"10.1039\/D0CC03243C","volume":"56","author":"Y Xiao","year":"2020","unstructured":"Xiao Y et al (2020) Discovery of histone deacetylase 3 (HDAC3)-specific PROTACs. CHEM COMMUN 56:9866","journal-title":"CHEM COMMUN"},{"key":"12213_CR90","doi-asserted-by":"publisher","first-page":"5642","DOI":"10.1021\/acs.jmedchem.1c02179","volume":"65","author":"JP Smalley","year":"2022","unstructured":"Smalley JP et al (2022) Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1\/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells. J MED CHEM 65:5642","journal-title":"J MED CHEM"},{"key":"12213_CR91","doi-asserted-by":"publisher","first-page":"115746","DOI":"10.1016\/j.ejmech.2023.115746","volume":"260","author":"S Chen","year":"2023","unstructured":"Chen S et al (2023) The application of PROTAC in HDAC. EUR J MED CHEM 260:115746","journal-title":"EUR J MED CHEM"},{"key":"12213_CR92","doi-asserted-by":"publisher","first-page":"21968","DOI":"10.1039\/D2RA03761K","volume":"12","author":"J Desantis","year":"2022","unstructured":"Desantis J et al (2022) PROTACs bearing piperazine-containing linkers: what effect on their protonation state? RSC ADV 12:21968","journal-title":"RSC ADV"},{"key":"12213_CR93","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1021\/acs.biochem.2c00288","volume":"62","author":"IM Baker","year":"2023","unstructured":"Baker IM, Smalley JP, Sabat KA, Hodgkinson JT, Cowley SM (2023) Comprehensive Transcriptomic Analysis of Novel Class I HDAC Proteolysis Targeting Chimeras (PROTACs). Biochemistry 62:645","journal-title":"Biochemistry"},{"key":"12213_CR94","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1038\/s41573-019-0047-y","volume":"18","author":"M Schapira","year":"2019","unstructured":"Schapira M, Calabrese MF, Bullock AN, Crews CM (2019) Targeted protein degradation: expanding the toolbox. NAT REV DRUG DISCOV 18:949","journal-title":"NAT REV DRUG DISCOV"},{"key":"12213_CR95","doi-asserted-by":"publisher","first-page":"16271","DOI":"10.1021\/acs.jmedchem.1c01576","volume":"64","author":"G Weng","year":"2021","unstructured":"Weng G, Li D, Kang Y, Hou T (2021) Integrative Modeling of PROTAC-Mediated Ternary Complexes. J MED CHEM 64:16271","journal-title":"J MED CHEM"},{"key":"12213_CR96","doi-asserted-by":"publisher","first-page":"6890","DOI":"10.1039\/D0CC02201B","volume":"56","author":"GM Burslem","year":"2020","unstructured":"Burslem GM, Bondeson DP, Crews CM (2020) Scaffold hopping enables direct access to more potent PROTACs with in vivo activity. CHEM COMMUN 56:6890","journal-title":"CHEM COMMUN"},{"key":"12213_CR97","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1177\/2472555220965528","volume":"26","author":"T Ishida","year":"2021","unstructured":"Ishida T, Ciulli A (2021) E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones. SLAS DISCOV 26:484","journal-title":"SLAS DISCOV"},{"key":"12213_CR98","doi-asserted-by":"publisher","first-page":"5279","DOI":"10.7150\/thno.55680","volume":"11","author":"W Wang","year":"2021","unstructured":"Wang W et al (2021) A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models. THERANOSTICS 11:5279","journal-title":"THERANOSTICS"},{"key":"12213_CR99","doi-asserted-by":"publisher","first-page":"801179","DOI":"10.3389\/fncel.2022.801179","volume":"16","author":"MC Silva","year":"2022","unstructured":"Silva MC et al (2022) Discovery and Optimization of Tau Targeted Protein Degraders Enabled by Patient Induced Pluripotent Stem Cells-Derived Neuronal Models of Tauopathy. FRONT CELL NEUROSCI 16:801179","journal-title":"FRONT CELL NEUROSCI"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12213-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12213-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12213-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T14:02:07Z","timestamp":1782568927000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12213-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,27]]},"references-count":99,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12213"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12213-y","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,27]]},"assertion":[{"value":"9 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1017"}}