{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:25:51Z","timestamp":1789053951788,"version":"build-2803163510"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2108085MH266"],"award-info":[{"award-number":["2108085MH266"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["1708085MH212"],"award-info":[{"award-number":["1708085MH212"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["KJ2017A195"],"award-info":[{"award-number":["KJ2017A195"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2023AH050564"],"award-info":[{"award-number":["2023AH050564"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Basic and Clinical Cooperative Research Promotion Program of Anhui Medical University","award":["2023xkjT028"],"award-info":[{"award-number":["2023xkjT028"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12235-6","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:11:15Z","timestamp":1783012275000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["ATPR promotes differentiation in gastric cancer cells by endocan"],"prefix":"10.1007","volume":"53","author":[{"given":"Jian","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingya","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengquan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"12235_CR1","doi-asserted-by":"publisher","first-page":"103841","DOI":"10.1016\/j.critrevonc.2022.103841","volume":"181","author":"MJ L\u00f3pez","year":"2023","unstructured":"L\u00f3pez MJ, Carbajal J, Alfaro AL, Saravia LG, Zanabria D, Araujo JM, Quispe L, Zevallos A, Buleje JL, Cho CE, Sarmiento M, Pinto JA, Fajardo W (2023) Characteristics of gastric cancer around the world. Crit Rev Oncol\/Hematol 181:103841. https:\/\/doi.org\/10.1016\/j.critrevonc.2022.103841","journal-title":"Crit Rev Oncol\/Hematol"},{"key":"12235_CR2","doi-asserted-by":"publisher","unstructured":"Peng H, Jiang L, Yuan J, Wu X, Chen N, Liu D, Liang Y, Xie Y, Jia K, Li Y, Feng X, Li J, Zhang X, Shen L, Chen Y (2024) Single-cell characterization of differentiation trajectories and drug resistance features in gastric cancer with peritoneal metastasis. Clinical and translational medicine. 14:e70054. https:\/\/doi.org\/10.1002\/ctm2.70054","DOI":"10.1002\/ctm2.70054"},{"key":"12235_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2015.03.013","author":"F Morceau","year":"2015","unstructured":"Morceau F, Chateauvieux S, Orsini M, Tr\u00e9cul A, Dicato M, Diederich M (2015) Natural compounds and pharmaceuticals reprogram leukemia cell differentiation pathways. Biotechnol Adv. https:\/\/doi.org\/10.1016\/j.biotechadv.2015.03.013. 33:785\u2009\u2013\u200997","journal-title":"Biotechnol Adv"},{"key":"12235_CR4","doi-asserted-by":"publisher","first-page":"3354","DOI":"10.1182\/blood.V89.9.3354","volume":"89","author":"Z-X Shen","year":"1997","unstructured":"Shen Z-X, Chen G-Q, Ni J-H, Li X-S, Xiong S-M, Qiu Q-Y, Zhu J, Tang W, Sun G-L, Yang K-Q, Chen Y, Zhou L, Fang Z-W, Wang Y-T, Ma J, Zhang P, Zhang T-D, Chen S-J, Chen Z, Wang Z-Y (1997) Use of Arsenic Trioxide (As2O3) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients. Blood 89:3354\u20133360. https:\/\/doi.org\/10.1182\/blood.V89.9.3354","journal-title":"Blood"},{"key":"12235_CR5","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0163-7258(96)00120-9","volume":"73","author":"RE Scott","year":"1997","unstructured":"Scott RE (1997) Differentiation, differentiation\/gene therapy and cancer. Pharmacol Ther 73:51\u201365. https:\/\/doi.org\/10.1016\/S0163-7258(96)00120-9","journal-title":"Pharmacol Ther"},{"key":"12235_CR6","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1182\/blood.V72.2.567.567","volume":"72","author":"H Meng-er","year":"1988","unstructured":"Meng-er H, Yu-chen Y, Shu-rong C, Jin-ren C, Jia-Xiang L, Lin Z, Long-jun G, Zhen-yi W (1988) Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 72:567\u2013572. https:\/\/doi.org\/10.1182\/blood.V72.2.567.567","journal-title":"Blood"},{"key":"12235_CR7","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1001\/jamaoncol.2021.5206","volume":"8","author":"MA Kutny","year":"2022","unstructured":"Kutny MA, Alonzo TA, Abla O, Rajpurkar M, Gerbing RB, Wang Y-C, Hirsch BA, Raimondi S, Kahwash S, Hardy KK, Hardy S, Meshinchi S, Gamis AS, Kolb EA, Feusner JH, Gregory J Jr. (2022) Assessment of arsenic trioxide and all-trans retinoic acid for the treatment of pediatric acute promyelocytic leukemia: a report from the children\u2019s oncology group aaml1331 trial. JAMA Oncol 8:79\u201387. https:\/\/doi.org\/10.1001\/jamaoncol.2021.5206","journal-title":"JAMA Oncol"},{"key":"12235_CR8","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/s41408-022-00753-y","volume":"12","author":"H-Y Wang","year":"2022","unstructured":"Wang H-Y, Gong S, Li G-H, Yao Y-Z, Zheng Y-S, Lu X-H, Wei S-H, Qin W-W, Liu H-B, Wang M-C, Xi J-Y, Chen L-M, Zhang M, Zhang X-X, Zhang H-Y, Zhang C-S, Wald DN, Zhu H-H, Liu L, He P-C (2022) An effective and chemotherapy-free strategy of all-trans retinoic acid and arsenic trioxide for acute promyelocytic leukemia in all risk groups (APL15 trial). Blood cancer J 12:158. https:\/\/doi.org\/10.1038\/s41408-022-00753-y","journal-title":"Blood cancer J"},{"key":"12235_CR9","doi-asserted-by":"publisher","first-page":"e71012","DOI":"10.1111\/jcmm.71012","volume":"30","author":"J Sun","year":"2026","unstructured":"Sun J, Zheng J, Zhu W, Bi Y, He Y (2026) All-Trans retinoic acid suppresses hepatocellular carcinoma progression via the CSTB\/CYTB axis. J Cell Mol Med 30:e71012. https:\/\/doi.org\/10.1111\/jcmm.71012","journal-title":"J Cell Mol Med"},{"key":"12235_CR10","doi-asserted-by":"publisher","unstructured":"Wang K, Qiu X, Zhang Z, Xu H, Tan Y, Su R, Gao F, Zhuo J, Li W, Lian Z, He H, Xu X (2023) ATRA sensitized the response of hepatocellular carcinoma to Sorafenib by downregulation of p21-activated kinase 1. Cell communication and signaling: CCS. 21:193. https:\/\/doi.org\/10.1186\/s12964-023-01194-1","DOI":"10.1186\/s12964-023-01194-1"},{"key":"12235_CR11","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/0753-3322(92)90002-O","volume":"46","author":"U Abel","year":"1992","unstructured":"Abel U (1992) Chemotherapy of advanced epithelial cancer - a critical review. Biomed Pharmacother 46:439\u2013452. https:\/\/doi.org\/10.1016\/0753-3322(92)90002-O","journal-title":"Biomed Pharmacother"},{"key":"12235_CR12","doi-asserted-by":"publisher","first-page":"113451","DOI":"10.1016\/j.ejmech.2021.113451","volume":"220","author":"C Liang","year":"2021","unstructured":"Liang C, Qiao G, Liu Y, Tian L, Hui N, Li J, Ma Y, Li H, Zhao Q, Cao W, Liu H, Ren X (2021) Overview of all-trans-retinoic acid (ATRA) and its analogues: Structures, activities, and mechanisms in acute promyelocytic leukaemia. Eur J Med Chem 220:113451. https:\/\/doi.org\/10.1016\/j.ejmech.2021.113451","journal-title":"Eur J Med Chem"},{"key":"12235_CR13","doi-asserted-by":"publisher","first-page":"148443","DOI":"10.1016\/j.gene.2024.148443","volume":"917","author":"S Liu","year":"2024","unstructured":"Liu S, Zhan W, He X, Hao M, Shen W, Zhang X, Wang M, Li Z, Hou R, Ou Z, Feng Y, Chen F (2024) ATPR induces acute promyelocytic leukemia cells differentiation and cycle arrest via the lncRNA CONCR\/DDX11\/PML-RAR\u03b1 signaling axis. Gene 917:148443. https:\/\/doi.org\/10.1016\/j.gene.2024.148443","journal-title":"Gene"},{"key":"12235_CR14","doi-asserted-by":"publisher","first-page":"6952","DOI":"10.1111\/jcmm.15353","volume":"24","author":"Y Du","year":"2020","unstructured":"Du Y, Zhang M-j, Li L-l, Xu X-L, Chen H, Feng Y-b, Li Y, Peng X-q, Chen F-h (2020) ATPR triggers acute myeloid leukaemia cells differentiation and cycle arrest via the RAR\u03b1\/LDHB\/ERK-glycolysis signalling axis. J Cell Mol Med 24:6952\u20136965. https:\/\/doi.org\/10.1111\/jcmm.15353","journal-title":"J Cell Mol Med"},{"key":"12235_CR15","doi-asserted-by":"publisher","first-page":"7687","DOI":"10.7314\/apjcp.2014.15.18.7687","volume":"15","author":"TT Fan","year":"2014","unstructured":"Fan TT, Cheng Y, Wang YF, Gui SY, Chen FH, Zhou Q, Wang Y (2014) A novel all-trans retinoid acid derivative N-(3-trifluoromethyl- phenyl)- retinamide inhibits lung adenocarcinoma A549 cell migration through down-regulating expression of myosin light chain kinase. Asian Pac J cancer prevention: APJCP 15:7687\u20137692. https:\/\/doi.org\/10.7314\/apjcp.2014.15.18.7687","journal-title":"Asian Pac J cancer prevention: APJCP"},{"key":"12235_CR16","doi-asserted-by":"publisher","first-page":"48341","DOI":"10.1074\/jbc.M108395200","volume":"276","author":"D B\u00e9chard","year":"2001","unstructured":"B\u00e9chard D, Gentina T, Delehedde M, Scherpereel A, Lyon M, Aumercier M, Vazeux R, Richet C, Degand P, Jude B, Janin A, Fernig DG, Tonnel A-B, Lassalle P (2001) Endocan is a novel chondroitin sulfate\/dermatan sulfate proteoglycan that promotes hepatocyte growth factor\/scatter factor mitogenic activity*. J Biol Chem 276:48341\u201348349. https:\/\/doi.org\/10.1074\/jbc.M108395200","journal-title":"J Biol Chem"},{"key":"12235_CR17","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.1007\/s11033-011-1043-4","volume":"39","author":"S Zhang","year":"2012","unstructured":"Zhang S, Zuo L, Gui S, Zhou Q, Wei W, Wang Y (2012) Induction of cell differentiation and promotion of endocan gene expression in stomach cancer by melatonin. Mol Biol Rep 39:2843\u20132849. https:\/\/doi.org\/10.1007\/s11033-011-1043-4","journal-title":"Mol Biol Rep"},{"key":"12235_CR18","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1042\/BST20210230","volume":"49","author":"P Fulghieri","year":"2021","unstructured":"Fulghieri P, Stivala LA, Sottile V (2021) Modulating cell differentiation in cancer models. Biochem Soc Trans 49:1803\u20131816. https:\/\/doi.org\/10.1042\/BST20210230","journal-title":"Biochem Soc Trans"},{"key":"12235_CR19","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1248\/yakushi.131.1465","volume":"131","author":"S-Y Gui","year":"2011","unstructured":"Gui S-Y, Chen F-H, Zhou Q, Wang Y (2011) Effects of novel all-trans retinoic acid retinamide derivatives on the proliferation and apoptosis of human lung adenocarcinoma cell line a549 cells. yakugaku zasshi: J Pharm Soc Japan 131:1465\u20131472. https:\/\/doi.org\/10.1248\/yakushi.131.1465","journal-title":"Yakugaku zasshi: J Pharm Soc Japan"},{"key":"12235_CR20","doi-asserted-by":"publisher","first-page":"16413","DOI":"10.1039\/d3ra01888a","volume":"13","author":"RS Jassas","year":"2023","unstructured":"Jassas RS, Naeem N, Sadiq A, Mehmood R, Alenazi NA, Al-Rooqi MM, Mughal EU, Alsantali RI, Ahmed SA (2023) Current status of N-, O-, S-heterocycles as potential alkaline phosphatase inhibitors: a medicinal chemistry overview. RSC Adv 13:16413\u201316452. https:\/\/doi.org\/10.1039\/d3ra01888a","journal-title":"RSC Adv"},{"key":"12235_CR21","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-013-0408-y","author":"U Sharma","year":"2014","unstructured":"Sharma U, Pal D, Prasad R (2014) Alkaline phosphatase: an overview. Indian J Clin biochemistry: IJCB. https:\/\/doi.org\/10.1007\/s12291-013-0408-y. 29:269\u2009\u2013\u200978","journal-title":"Indian J Clin biochemistry: IJCB"},{"key":"12235_CR22","doi-asserted-by":"publisher","first-page":"6124","DOI":"10.1002\/cam4.1820","volume":"7","author":"Y Feng","year":"2018","unstructured":"Feng Y, Xiong Y, Qiao T, Li X, Jia L, Han Y (2018) Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy. Cancer Med 7:6124\u20136136. https:\/\/doi.org\/10.1002\/cam4.1820","journal-title":"Cancer Med"},{"key":"12235_CR23","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1158\/0008-5472.CAN-08-2590","volume":"69","author":"N Almog","year":"2009","unstructured":"Almog N, Ma L, Raychowdhury R, Schwager C, Erber R, Short S, Hlatky L, Vajkoczy P, Huber PE, Folkman J, Abdollahi A (2009) Transcriptional Switch of Dormant Tumors to Fast-Growing Angiogenic Phenotype. Cancer Res 69:836\u2013844. https:\/\/doi.org\/10.1158\/0008-5472.CAN-08-2590","journal-title":"Cancer Res"},{"key":"12235_CR24","doi-asserted-by":"publisher","DOI":"10.48101\/ujms.v.13337","author":"Z Wang","year":"2026","unstructured":"Wang Z, Zhao Y, Luo M, Yang J, Geng Z, Ou S, Huang Z, Sun R, Luo X, Jin K, Wang F, Zhang X (2026) Endocan attenuates LPS-induced alveolar type II cells injury through PI3K\/Akt\/mTOR pathway. Ups J Med Sci. https:\/\/doi.org\/10.48101\/ujms.v131.13337","journal-title":"Ups J Med Sci"},{"key":"12235_CR25","doi-asserted-by":"publisher","first-page":"14915","DOI":"10.1007\/s13277-016-5398-y","volume":"37","author":"Z Sumei","year":"2016","unstructured":"Sumei Z, Shaolong C, Xiang W, Yinliang Q, Qing Z, Yuan W (2016) Endocan reduces the malign grade of gastric cancer cells by regulating associated protein expression. Tumor Biology 37:14915\u201314921. https:\/\/doi.org\/10.1007\/s13277-016-5398-y","journal-title":"Tumor Biology"},{"key":"12235_CR26","doi-asserted-by":"publisher","first-page":"4562","DOI":"10.3748\/wjg.14.4562","volume":"14","author":"L Zuo","year":"2008","unstructured":"Zuo L, Zhang SM, Hu RL, Zhu HQ, Zhou Q, Gui SY, Wu Q, Wang Y (2008) Correlation between expression and differentiation of endocan in colorectal cancer. World J Gastroenterol 14:4562\u20134568. https:\/\/doi.org\/10.3748\/wjg.14.4562","journal-title":"World J Gastroenterol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12235-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12235-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12235-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:11:16Z","timestamp":1783012276000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12235-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12235"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12235-6","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,2]]},"assertion":[{"value":"29 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1076"}}