{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:22:44Z","timestamp":1783012964843,"version":"3.54.6"},"reference-count":100,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82505350"],"award-info":[{"award-number":["82505350"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences","award":["CI2023C015YL"],"award-info":[{"award-number":["CI2023C015YL"]}]},{"name":"High Level Chinese Medical Hospital Promotion Project","award":["HLCMHPP2023085"],"award-info":[{"award-number":["HLCMHPP2023085"]}]},{"name":"National Key Research and Development Program of China, Key Special Project on Modernization of Traditional Chinese Medicine","award":["2025YFC3512800 and 2025YFC3512803"],"award-info":[{"award-number":["2025YFC3512800 and 2025YFC3512803"]}]},{"name":"National Science and Technology Major Project of China","award":["2026ZD0554100"],"award-info":[{"award-number":["2026ZD0554100"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12245-4","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T15:42:51Z","timestamp":1783006971000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inflammasomes in digestive diseases: mechanisms and therapeutic potential"],"prefix":"10.1007","volume":"53","author":[{"given":"Yanjiao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinqiao","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"12245_CR1","doi-asserted-by":"crossref","unstructured":"De Luca R, Arr\u00e8 V, Nardone S, Incerpi S, Giannelli G, Trivedi P et al (2025) Gastrointestinal microbiota and inflammasomes interplay in health and disease: a gut feeling. Gut","DOI":"10.1136\/gutjnl-2025-334938"},{"issue":"7849","key":"12245_CR2","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1038\/s41586-021-03231-w","volume":"591","author":"WC Chou","year":"2021","unstructured":"Chou WC, Guo Z, Guo H, Chen L, Zhang G, Liang K et al (2021) AIM2 in regulatory T cells restrains autoimmune diseases. Nature 591(7849):300\u2013305","journal-title":"Nature"},{"issue":"1","key":"12245_CR3","doi-asserted-by":"publisher","first-page":"13524","DOI":"10.1038\/s41598-023-39805-z","volume":"13","author":"G Ambrus-Aikelin","year":"2023","unstructured":"Ambrus-Aikelin G, Takeda K, Joetham A, Lazic M, Povero D, Santini AM et al (2023) JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders. Sci Rep 13(1):13524","journal-title":"Sci Rep"},{"issue":"12","key":"12245_CR4","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1038\/cr.2015.139","volume":"25","author":"WT He","year":"2015","unstructured":"He WT, Wan H, Hu L, Chen P, Wang X, Huang Z et al (2015) Gasdermin D is an executor of pyroptosis and required for interleukin-1\u03b2 secretion. Cell Res 25(12):1285\u20131298","journal-title":"Cell Res"},{"issue":"1","key":"12245_CR5","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/s41392-021-00687-0","volume":"6","author":"D Li","year":"2021","unstructured":"Li D, Wu M (2021) Pattern recognition receptors in health and diseases. Signal Transduct Target Ther 6(1):291","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"12245_CR6","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/s41422-025-01096-6","volume":"35","author":"G Zou","year":"2025","unstructured":"Zou G, Tang Y, Yang J, Fu S, Li Y, Ren X et al (2025) Signal-induced NLRP3 phase separation initiates inflammasome activation. Cell Res 35(6):437\u2013452","journal-title":"Cell Res"},{"key":"12245_CR7","doi-asserted-by":"crossref","unstructured":"Yi YS (2024) Regulatory Roles of Noncanonical Inflammasomes in Inflammatory Lung Diseases. Int J Mol Sci. ;26(1)","DOI":"10.3390\/ijms26010027"},{"issue":"12","key":"12245_CR8","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1038\/s41556-023-01269-8","volume":"25","author":"P Kumari","year":"2023","unstructured":"Kumari P, Vasudevan SO, Russo AJ, Wright SS, Fraile-\u00c1greda V, Krajewski D et al (2023) Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis. Nat Cell Biol 25(12):1860\u20131872","journal-title":"Nat Cell Biol"},{"issue":"2","key":"12245_CR9","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1111\/imm.12787","volume":"152","author":"YS Yi","year":"2017","unstructured":"Yi YS (2017) Caspase-11 non-canonical inflammasome: a critical sensor of intracellular lipopolysaccharide in macrophage-mediated inflammatory responses. Immunology 152(2):207\u2013217","journal-title":"Immunology"},{"key":"12245_CR10","doi-asserted-by":"crossref","unstructured":"Yi YS (2024) Roles of the Caspase-11 Non-Canonical Inflammasome in Rheumatic Diseases. Int J Mol Sci. ;25(4)","DOI":"10.3390\/ijms25042091"},{"issue":"6","key":"12245_CR11","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1016\/j.cell.2015.10.048","volume":"163","author":"M Levy","year":"2015","unstructured":"Levy M, Thaiss CA, Zeevi D, Dohnalov\u00e1 L, Zilberman-Schapira G, Mahdi JA et al (2015) Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling. Cell 163(6):1428\u20131443","journal-title":"Cell"},{"issue":"5","key":"12245_CR12","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/j.cell.2014.01.026","volume":"156","author":"M Wlodarska","year":"2014","unstructured":"Wlodarska M, Thaiss CA, Nowarski R, Henao-Mejia J, Zhang JP, Brown EM et al (2014) NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell 156(5):1045\u20131059","journal-title":"Cell"},{"issue":"4","key":"12245_CR13","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.it.2011.02.002","volume":"32","author":"MH Zaki","year":"2011","unstructured":"Zaki MH, Lamkanfi M, Kanneganti TD (2011) The Nlrp3 inflammasome: contributions to intestinal homeostasis. Trends Immunol 32(4):171\u2013179","journal-title":"Trends Immunol"},{"issue":"2","key":"12245_CR14","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.chom.2014.07.001","volume":"16","author":"ME Sellin","year":"2014","unstructured":"Sellin ME, M\u00fcller AA, Felmy B, Dolowschiak T, Diard M, Tardivel A et al (2014) Epithelium-intrinsic NAIP\/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa. Cell Host Microbe 16(2):237\u2013248","journal-title":"Cell Host Microbe"},{"issue":"9","key":"12245_CR15","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1016\/j.celrep.2015.10.040","volume":"13","author":"S Hu","year":"2015","unstructured":"Hu S, Peng L, Kwak YT, Tekippe EM, Pasare C, Malter JS et al (2015) The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense. Cell Rep 13(9):1922\u20131936","journal-title":"Cell Rep"},{"key":"12245_CR16","doi-asserted-by":"crossref","unstructured":"Y R, E, Y, S L, M RL, S H, C ZW (2018) IL-12\u2009+\u2009IL-18 Cosignaling in Human Macrophages and Lung Epithelial Cells Activates Cathelicidin and Autophagy, Inhibiting Intracellular Mycobacterial Growth. J Immunol (Baltimore Md: 1950) 200(7):2405\u20132417","DOI":"10.4049\/jimmunol.1701073"},{"issue":"9","key":"12245_CR17","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1038\/ni1496","volume":"8","author":"EV Acosta-Rodriguez","year":"2007","unstructured":"Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F (2007) Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 8(9):942\u2013949","journal-title":"Nat Immunol"},{"key":"12245_CR18","unstructured":"V Y. Comparative Transcriptomic Profiling Identifies IL-1\u03b2 as a Non-Canonical Driver of Human Dendritic Cell Maturation. Iran J Biotechnol. (2026) ;24(1):e4185"},{"issue":"3","key":"12245_CR19","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.immuni.2010.03.003","volume":"32","author":"MH Zaki","year":"2010","unstructured":"Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti TD (2010) The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity 32(3):379\u2013391","journal-title":"Immunity"},{"issue":"6","key":"12245_CR20","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1016\/j.cell.2015.10.072","volume":"163","author":"R Nowarski","year":"2015","unstructured":"Nowarski R, Jackson R, Gagliani N, de Zoete MR, Palm NW, Bailis W et al (2015) Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis. Cell 163(6):1444\u20131456","journal-title":"Cell"},{"issue":"1","key":"12245_CR21","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1186\/s12876-021-01880-9","volume":"21","author":"PY JB","year":"2021","unstructured":"JB PY, SBU R (2021) Genotype-phenotype associations of polymorphisms within the gene locus of NOD-like receptor pyrin domain containing 3 in Swiss inflammatory bowel disease patients. BMC Gastroenterol 21(1):310","journal-title":"BMC Gastroenterol"},{"issue":"1","key":"12245_CR22","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/imr.12534","volume":"277","author":"SM Man","year":"2017","unstructured":"Man SM, Karki R, Kanneganti TD (2017) Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases. Immunol Rev 277(1):61\u201375","journal-title":"Immunol Rev"},{"issue":"1","key":"12245_CR23","doi-asserted-by":"publisher","first-page":"3728","DOI":"10.1038\/s41467-018-06125-0","volume":"9","author":"H Tye","year":"2018","unstructured":"Tye H, Yu CH, Simms LA, de Zoete MR, Kim ML, Zakrzewski M et al (2018) NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease. Nat Commun 9(1):3728","journal-title":"Nat Commun"},{"issue":"5","key":"12245_CR24","doi-asserted-by":"publisher","first-page":"100580","DOI":"10.1016\/j.bj.2023.01.004","volume":"46","author":"SL Wang","year":"2023","unstructured":"Wang SL, Zhang MM, Zhou H, Su GQ, Ding Y, Xu GH et al (2023) Inhibition of NLRP3 attenuates sodium dextran sulfate-induced inflammatory bowel disease through gut microbiota regulation. Biomed J 46(5):100580","journal-title":"Biomed J"},{"issue":"5","key":"12245_CR25","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.it.2010.01.007","volume":"31","author":"R LM","year":"2010","unstructured":"LM R (2010) Lessons from the inflammasome: a molecular sentry linking Candida and Crohn\u2019s disease. Trends Immunol 31(5):171\u2013175","journal-title":"Trends Immunol"},{"issue":"2","key":"12245_CR26","doi-asserted-by":"publisher","first-page":"e0073021","DOI":"10.1128\/Spectrum.00730-21","volume":"9","author":"S Qu","year":"2021","unstructured":"Qu S, Fan L, Qi Y, Xu C, Hu Y, Chen S et al (2021) Akkermansia muciniphila Alleviates Dextran Sulfate Sodium (DSS)-Induced Acute Colitis by NLRP3 Activation. Microbiol Spectr 9(2):e0073021","journal-title":"Microbiol Spectr"},{"issue":"5","key":"12245_CR27","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.cell.2011.04.022","volume":"145","author":"EETS AL","year":"2011","unstructured":"AL EETS, J H-M, CA K, CJ T (2011) NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145(5):745\u2013757","journal-title":"Cell"},{"issue":"4","key":"12245_CR28","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.celrep.2017.03.080","volume":"19","author":"SS Seregin","year":"2017","unstructured":"Seregin SS, Golovchenko N, Schaf B, Chen J, Pudlo NA, Mitchell J et al (2017) NLRP6 Protects Il10 -\/- Mice from Colitis by Limiting Colonization of Akkermansia muciniphila. Cell Rep 19(4):733\u2013745","journal-title":"Cell Rep"},{"key":"12245_CR29","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.jare.2023.08.008","volume":"52","author":"YA Z","year":"2023","unstructured":"Z YA (2023) Targeting Desulfovibrio vulgaris flagellin-induced NAIP\/NLRC4 inflammasome activation in macrophages attenuates ulcerative colitis. J Adv Res 52:219\u2013232","journal-title":"J Adv Res"},{"issue":"5","key":"12245_CR30","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/ni.3690","volume":"18","author":"LC JE","year":"2017","unstructured":"JE LC, MJ W, WC K, SA C, AD M (2017) NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth. Nat Immunol 18(5):541\u2013551","journal-title":"Nat Immunol"},{"key":"12245_CR31","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.jconrel.2024.01.051","volume":"367","author":"Y Zhao","year":"2024","unstructured":"Zhao Y, Yin W, Yang Z, Sun J, Chang J, Huang L et al (2024) Nanotechnology-enabled M2 macrophage polarization and ferroptosis inhibition for targeted inflammatory bowel disease treatment. J Control Release 367:339\u2013353","journal-title":"J Control Release"},{"key":"12245_CR32","doi-asserted-by":"publisher","first-page":"156640","DOI":"10.1016\/j.phymed.2025.156640","volume":"143","author":"SY BH","year":"2025","unstructured":"BH SY, WW L, XT CHM, JC H (2025) Polyphyllin \u2165 modulates macrophage polarization through autophagy-NLRP3 inflammasome to alleviate inflammatory bowel disease. Phytomedicine: Int J phytotherapy phytopharmacology 143:156640","journal-title":"Phytomedicine: Int J phytotherapy phytopharmacology"},{"key":"12245_CR33","doi-asserted-by":"crossref","unstructured":"Mak\u2019Anyengo R, Duewell P, Reichl C, H\u00f6rth C, Lehr HA, Fischer S et al (2018) Nlrp3-dependent IL-1\u03b2 inhibits CD103\u2009+\u2009dendritic cell differentiation in the gut. JCI Insight. ;3(5)","DOI":"10.1172\/jci.insight.96322"},{"issue":"Suppl 1","key":"12245_CR34","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1159\/000341681","volume":"30","author":"C Bauer","year":"2012","unstructured":"Bauer C, Duewell P, Lehr HA, Endres S, Schnurr M (2012) Protective and aggravating effects of Nlrp3 inflammasome activation in IBD models: influence of genetic and environmental factors. Dig Dis 30(Suppl 1):82\u201390","journal-title":"Dig Dis"},{"issue":"1","key":"12245_CR35","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1038\/s41467-017-01917-2","volume":"8","author":"X Yao","year":"2017","unstructured":"Yao X, Zhang C, Xing Y, Xue G, Zhang Q, Pan F et al (2017) Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis. Nat Commun 8(1):1896","journal-title":"Nat Commun"},{"issue":"9","key":"12245_CR36","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1136\/gut.2009.197822","volume":"59","author":"C Bauer","year":"2010","unstructured":"Bauer C, Duewell P, Mayer C, Lehr HA, Fitzgerald KA, Dauer M et al (2010) Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome. Gut 59(9):1192\u20131199","journal-title":"Gut"},{"key":"12245_CR37","doi-asserted-by":"crossref","unstructured":"LM W, SB S, I MN (2025) R, T V, C S, Neonatal neutrophils exhibit reduced NLRP3 inflammasome activation. J Leukoc Biol. ;117(2)","DOI":"10.1093\/jleuko\/qiae206"},{"key":"12245_CR38","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.2147\/JIR.S503033","volume":"18","author":"RC J","year":"2025","unstructured":"J RC (2025) Metformin Ameliorates Ulcerative Colitis Through Inhibiting NLRP3 Inflammasome Activation. J Inflamm Res 18:1773\u20131786","journal-title":"J Inflamm Res"},{"issue":"9","key":"12245_CR39","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1084\/jem.20111453","volume":"209","author":"MC OJ","year":"2012","unstructured":"OJ MC, B B HCSMJA (2012) IL-1\u03b2 mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells. J Exp Med 209(9):1595\u20131609","journal-title":"J Exp Med"},{"issue":"1","key":"12245_CR40","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.cell.2019.12.016","volume":"180","author":"A Jarret","year":"2020","unstructured":"Jarret A, Jackson R, Duizer C, Healy ME, Zhao J, Rone JM et al (2020) Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity. Cell 180(1):50\u201363e12","journal-title":"Cell"},{"issue":"4","key":"12245_CR41","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/mi.2013.94","volume":"7","author":"GX Song-Zhao","year":"2014","unstructured":"Song-Zhao GX, Srinivasan N, Pott J, Baban D, Frankel G, Maloy KJ (2014) Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen. Mucosal Immunol 7(4):763\u2013774","journal-title":"Mucosal Immunol"},{"key":"12245_CR42","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3389\/fimmu.2017.00036","volume":"8","author":"C Pellegrini","year":"2017","unstructured":"Pellegrini C, Antonioli L, Lopez-Castejon G, Blandizzi C, Fornai M (2017) Canonical and Non-Canonical Activation of NLRP3 Inflammasome at the Crossroad between Immune Tolerance and Intestinal Inflammation. Front Immunol 8:36","journal-title":"Front Immunol"},{"key":"12245_CR43","doi-asserted-by":"publisher","first-page":"115209","DOI":"10.1016\/j.intimp.2025.115209","volume":"163","author":"S Chen","year":"2025","unstructured":"Chen S, Yan L, Zeng J, Meng W, Zhuang J, Chen F et al (2025) Therapeutic effects of D-cycloserine in mouse models of IBD and CAC: Targeting NLRP3 inflammasome and intestinal barrier integrity. Int Immunopharmacol 163:115209","journal-title":"Int Immunopharmacol"},{"issue":"7575","key":"12245_CR44","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/nature15514","volume":"526","author":"JSYZ K W","year":"2015","unstructured":"K W JSYZ (2015) Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526(7575):660\u2013665","journal-title":"Nature"},{"key":"12245_CR45","doi-asserted-by":"crossref","unstructured":"Fu J, Jiang Z, Wen C, Su W, Yang M, He H et al (2025) Bacterial infection in weaned piglets promotes diarrhea by inducing the NLRP3 inflammasome-pyroptosis pathway. Sci China Life Sci. ;null","DOI":"10.1007\/s11427-024-2728-2"},{"issue":"5","key":"12245_CR46","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/j.cell.2014.01.026","volume":"156","author":"MW CA","year":"2014","unstructured":"CA MW, J H-M, JP TRN (2014) NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell 156(5):1045\u20131059","journal-title":"Cell"},{"key":"12245_CR47","first-page":"1535","volume-title":"A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion","author":"B GM","year":"2016","unstructured":"GM B, EE N, GC MEJ (2016) H. A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion, vol 352. Science, New York, NY, pp 1535\u20131542. 6293"},{"issue":"1","key":"12245_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12964-022-00954-9","volume":"21","author":"Q Yu","year":"2023","unstructured":"Yu Q, Shi H, Ding Z, Wang Z, Yao H, Lin R (2023) The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation in Helicobacter pylori-associated gastritis by regulating ROS and autophagy. Cell Commun Signal 21(1):1","journal-title":"Cell Commun Signal"},{"key":"12245_CR49","doi-asserted-by":"crossref","unstructured":"Li X, Liu S, Luo J, Liu A, Tang S, Liu S et al (2015) Helicobacter pylori induces IL-1\u03b2 and IL-18 production in human monocytic cell line through activation of NLRP3 inflammasome via ROS signaling pathway. Pathog Dis. ;73(4)","DOI":"10.1093\/femspd\/ftu024"},{"issue":"7","key":"12245_CR50","doi-asserted-by":"publisher","first-page":"3566","DOI":"10.4049\/jimmunol.1400362","volume":"193","author":"RP Semper","year":"2014","unstructured":"Semper RP, Mej\u00edas-Luque R, Gro\u00df C, Anderl F, M\u00fcller A, Vieth M et al (2014) Helicobacter pylori-induced IL-1\u03b2 secretion in innate immune cells is regulated by the NLRP3 inflammasome and requires the cag pathogenicity island. J Immunol 193(7):3566\u20133576","journal-title":"J Immunol"},{"key":"12245_CR51","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.3389\/fimmu.2020.01121","volume":"11","author":"AR Jang","year":"2020","unstructured":"Jang AR, Kang MJ, Shin JI, Kwon SW, Park JY, Ahn JH et al (2020) Unveiling the Crucial Role of Type IV Secretion System and Motility of Helicobacter pylori in IL-1\u03b2 Production via NLRP3 Inflammasome Activation in Neutrophils. Front Immunol 11:1121","journal-title":"Front Immunol"},{"key":"12245_CR52","doi-asserted-by":"publisher","first-page":"119272","DOI":"10.1016\/j.jep.2024.119272","volume":"340","author":"J Liu","year":"2025","unstructured":"Liu J, Chen Y, Zhang J, Zheng Y, An Y, Xia C et al (2025) Vitexin alleviates MNNG-induced chronic atrophic gastritis via inhibiting NLRP3 inflammasome. J Ethnopharmacol 340:119272","journal-title":"J Ethnopharmacol"},{"issue":"7","key":"12245_CR53","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1136\/gutjnl-2014-307175","volume":"65","author":"GZ Ng","year":"2016","unstructured":"Ng GZ, Menheniott TR, Every AL, Stent A, Judd LM, Chionh YT et al (2016) The MUC1 mucin protects against Helicobacter pylori pathogenesis in mice by regulation of the NLRP3 inflammasome. Gut 65(7):1087\u20131099","journal-title":"Gut"},{"issue":"1","key":"12245_CR54","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12964-024-02017-7","volume":"23","author":"X Fei","year":"2025","unstructured":"Fei X, Chen S, Li L, Xu X, Wang H, Ke H et al (2025) Helicobacter pylori infection promotes M1 macrophage polarization and gastric inflammation by activation of NLRP3 inflammasome via TNF\/TNFR1 axis. Cell Commun Signal 23(1):6","journal-title":"Cell Commun Signal"},{"issue":"5","key":"12245_CR55","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1111\/imcb.12641","volume":"101","author":"RE Dawson","year":"2023","unstructured":"Dawson RE, Deswaerte V, West AC, Sun E, Wray-McCann G, Livis T et al (2023) The cytosolic DNA sensor AIM2 promotes Helicobacter-induced gastric pathology via the inflammasome. Immunol Cell Biol 101(5):444\u2013457","journal-title":"Immunol Cell Biol"},{"key":"12245_CR56","doi-asserted-by":"crossref","unstructured":"M E-Z SB (2020) M Z, H G, G H, H H, Aim2-mediated\/IFN-\u03b2-independent regulation of gastric metaplastic lesions via CD8\u2009+\u2009T cells. JCI insight. ;5(5)","DOI":"10.1172\/jci.insight.94035"},{"issue":"8","key":"12245_CR57","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.4049\/jimmunol.1900351","volume":"203","author":"RP Semper","year":"2019","unstructured":"Semper RP, Vieth M, Gerhard M, Mej\u00edas-Luque R (2019) Helicobacter pylori Exploits the NLRC4 Inflammasome to Dampen Host Defenses. J Immunol 203(8):2183\u20132193","journal-title":"J Immunol"},{"key":"12245_CR58","doi-asserted-by":"crossref","unstructured":"Y B-C ET, S A-D, N M-O TA, S O-O AT (2025) Determination of the Roles of H. pylori Outer Membrane Virulence Factors and Pyroptosis-Associated NLRP3, ASC, Caspase-1, Gasdermin D, IL-1\u03b2, and IL-18 in Ulcer and Gastritis Pathogenesis. Biology. ;14(6)","DOI":"10.3390\/biology14060634"},{"key":"12245_CR59","doi-asserted-by":"crossref","unstructured":"Zhou Z, Hu C, Cui B, You L, An R, Liang K, Wang X (2024) Ginsenoside Rg1 Suppresses Pyroptosis via the NF-\u03baB\/NLRP3\/GSDMD Pathway to Alleviate Chronic Atrophic Gastritis In Vitro and In Vivo. J Agric Food Chem. ;null","DOI":"10.1021\/acs.jafc.4c01271"},{"issue":"1","key":"12245_CR60","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s40360-021-00509-7","volume":"22","author":"J Xie","year":"2021","unstructured":"Xie J, Fan L, Xiong L, Chen P, Wang H, Chen H et al (2021) Rabeprazole inhibits inflammatory reaction by inhibition of cell pyroptosis in gastric epithelial cells. BMC Pharmacol Toxicol 22(1):44","journal-title":"BMC Pharmacol Toxicol"},{"key":"12245_CR61","doi-asserted-by":"crossref","unstructured":"Y PC (2024) W, H T, Z L, J W, T W, Gastrodenol suppresses NLRP3\/GSDMD mediated pyroptosis and ameliorates inflammatory diseases. Cell Immunol. ;405\u2013406:104888","DOI":"10.1016\/j.cellimm.2024.104888"},{"issue":"1","key":"12245_CR62","doi-asserted-by":"publisher","first-page":"12200","DOI":"10.1038\/s41598-017-11744-6","volume":"7","author":"IP C","year":"2017","unstructured":"C IP, DM RLA (2017) Lack of NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD. Sci Rep 7(1):12200","journal-title":"Sci Rep"},{"key":"12245_CR63","doi-asserted-by":"crossref","unstructured":"H Y, Y L, W C, X B, P D, J W. Antarctic krill peptide alleviates liver fibrosis via downregulating the secondary bile acid mediated NLRP3 signaling pathway. Food Funct. (2022) ;13(14):7740\u20137749","DOI":"10.1039\/D1FO04241F"},{"issue":"1","key":"12245_CR64","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1210\/endrev\/bnae025","volume":"46","author":"HF R RE-L","year":"2025","unstructured":"R RE-L HF, NG B, D KZ NR (2025) Postbiotic Impact on Host Metabolism and Immunity Provides Therapeutic Potential in Metabolic Disease. Endocr Rev 46(1):60\u201379","journal-title":"Endocr Rev"},{"issue":"3","key":"12245_CR65","doi-asserted-by":"publisher","first-page":"e0302024","DOI":"10.1128\/mbio.03020-24","volume":"16","author":"T X","year":"2025","unstructured":"X T, W TZWD, Z YL (2025) Gut microbe-derived betulinic acid alleviates sepsis-induced acute liver injury by inhibiting macrophage NLRP3 inflammasome in mice. mBio 16(3):e0302024","journal-title":"mBio"},{"issue":"7384","key":"12245_CR66","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature10809","volume":"482","author":"EE J H-M","year":"2012","unstructured":"J H-M EE, C J, WZ LH (2012) Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482(7384):179\u2013185","journal-title":"Nature"},{"issue":"3","key":"12245_CR67","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/nrgastro.2012.21","volume":"9","author":"Microbiota","year":"2012","unstructured":"NJ W, Microbiota (2012) Dysbiosis driven by inflammasome deficiency exacerbates hepatic steatosis and governs rate of NAFLD progression. Nat reviews Gastroenterol Hepatol 9(3):123","journal-title":"Nat reviews Gastroenterol Hepatol"},{"issue":"4","key":"12245_CR68","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.jcmgh.2020.11.002","volume":"11","author":"S KM","year":"2021","unstructured":"KM S, C E, A G, CV S, EJC G (2021) Intestinal Dysbiosis Amplifies Acetaminophen-Induced Acute Liver Injury. Cell Mol Gastroenterol Hepatol 11(4):909\u2013933","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"64","key":"12245_CR69","doi-asserted-by":"publisher","first-page":"eabj3859","DOI":"10.1126\/sciimmunol.abj3859","volume":"6","author":"W C","year":"2021","unstructured":"C W, T Y, C JX (2021) NLRP3 inflammasome activation triggers gasdermin D-independent inflammation. Sci Immunol 6(64):eabj3859","journal-title":"Sci Immunol"},{"issue":"1","key":"12245_CR70","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jhep.2020.07.041","volume":"74","author":"SGALFABK CD","year":"2021","unstructured":"CD SGALFABK, LA J (2021) Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis. J Hepatol 74(1):156\u2013167","journal-title":"J Hepatol"},{"key":"12245_CR71","doi-asserted-by":"publisher","first-page":"108126","DOI":"10.1016\/j.intimp.2021.108126","volume":"100","author":"SR C","year":"2021","unstructured":"C SR, X HYSJW (2021) Antcin A alleviates pyroptosis and inflammatory response in Kupffercells of non-alcoholic fatty liver disease by targeting NLRP3. Int Immunopharmacol 100:108126","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"12245_CR72","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1186\/s12964-024-01944-9","volume":"22","author":"YZRWXZ XY","year":"2024","unstructured":"XY YZRWXZ, LW W (2024) Neutrophil extracellular traps facilitate liver inflammation\/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis. Cell communication signaling: CCS 22(1):556","journal-title":"Cell communication signaling: CCS"},{"issue":"8","key":"12245_CR73","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1038\/s41401-024-01239-2","volume":"45","author":"Z FL","year":"2024","unstructured":"FL Z, XT YZZHWHZ, YQ M (2024) Neutrophil extracellular traps promote acetaminophen-induced acute liver injury in mice via AIM2. Acta Pharmacol Sin 45(8):1660\u20131672","journal-title":"Acta Pharmacol Sin"},{"key":"12245_CR74","doi-asserted-by":"publisher","first-page":"1567916","DOI":"10.3389\/fcell.2025.1567916","volume":"13","author":"P Ros-Tarraga","year":"2025","unstructured":"Ros-Tarraga P, Villanueva-Badenas E, Sanchez-Gonzalez E, Gallego-Ferrer G, Donato MT, Tolosa L (2025) Challenges of in vitro modelling of liver fibrosis. Front Cell Dev Biol 13:1567916","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"12245_CR75","doi-asserted-by":"publisher","first-page":"19648","DOI":"10.1038\/s41598-024-69764-y","volume":"14","author":"O HA","year":"2024","unstructured":"HA O, SMA A, MH H, AA H, AE A, SS E et al (2024) NLRP3 inflammasome pathway involved in the pathogenesis of metabolic associated fatty liver disease. Sci Rep 14(1):19648","journal-title":"Sci Rep"},{"issue":"2","key":"12245_CR76","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1002\/hep.30252","volume":"69","author":"I ME","year":"2019","unstructured":"ME I, CD J, TM H, MD M, C T, BG P et al (2019) NLR Family Pyrin Domain-Containing 3 Inflammasome Activation in Hepatic Stellate Cells Induces Liver Fibrosis in Mice. Hepatology (Baltimore MD) 69(2):845\u2013859","journal-title":"Hepatology (Baltimore MD)"},{"issue":"3","key":"12245_CR77","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1002\/hep.26592","volume":"59","author":"AWAE MD","year":"2014","unstructured":"MD AWAE, CA M, CD P (2014) NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice. Hepatology (Baltimore MD) 59(3):898\u2013910","journal-title":"Hepatology (Baltimore MD)"},{"issue":"5","key":"12245_CR78","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","volume":"66","author":"M AR","year":"2017","unstructured":"AR M, AAB AW, MM R, CD Y, DM J (2017) NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. J Hepatol 66(5):1037\u20131046","journal-title":"J Hepatol"},{"key":"12245_CR79","unstructured":"LY X, NR Y, SL H, QS HQLQ (2025) Z, Y L. Dehydrotrametenolic acid methyl ester, a triterpenoid of Poria cocos, alleviates non-alcoholic steatohepatitis by suppressing NLRP3 inflammasome activation via targeting Caspase-1 in mice. Acta pharmacologica Sinica. ;null"},{"issue":"6","key":"12245_CR80","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1002\/hep.32776","volume":"77","author":"J Knorr","year":"2023","unstructured":"Knorr J, Kaufmann B, Inzaugarat ME, Holtmann TM, Geisler L, Hundertmark J et al (2023) Interleukin-18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Hepatology 77(6):1968\u20131982","journal-title":"Hepatology"},{"key":"12245_CR81","doi-asserted-by":"crossref","unstructured":"Y S, H Y, D W, H Y, D H. NLRP3 inflammasome inhibitor MCC950 can reduce the damage of pancreatic and intestinal barrier function in mice with acute pancreatitis. Acta cirurgica brasileira. (2022) ;37(7):e370706","DOI":"10.1590\/acb370706"},{"issue":"1","key":"12245_CR82","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1053\/j.gastro.2019.09.040","volume":"158","author":"M Sendler","year":"2020","unstructured":"Sendler M, van den Brandt C, Glaubitz J, Wilden A, Golchert J, Weiss FU et al (2020) NLRP3 Inflammasome Regulates Development of Systemic Inflammatory Response and Compensatory Anti-Inflammatory Response Syndromes in Mice With Acute Pancreatitis. Gastroenterology 158(1):253\u201369e14","journal-title":"Gastroenterology"},{"key":"12245_CR83","first-page":"1294951","volume":"2018","author":"F Q","year":"2018","unstructured":"Q F, Z Z (2018) NLRP3 Deficiency Alleviates Severe Acute Pancreatitis and Pancreatitis-Associated Lung Injury in a Mouse Model. Biomed Res Int 2018:1294951","journal-title":"Biomed Res Int"},{"issue":"3","key":"12245_CR84","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.pan.2017.03.006","volume":"17","author":"E F A-C","year":"2017","unstructured":"F A-C E, d-M B, L-R, C M-C, N Q-V VB et al (2017) The expression and activation of the AIM2 inflammasome correlates with inflammation and disease severity in patients with acute pancreatitis. Pancreatology: official J Int Association Pancreatology (IAP) [et al] 17(3):364\u2013371","journal-title":"Pancreatology: official J Int Association Pancreatology (IAP) [et al]"},{"issue":"10","key":"12245_CR85","doi-asserted-by":"publisher","first-page":"4331","DOI":"10.4049\/jimmunol.1502340","volume":"196","author":"R Kang","year":"2016","unstructured":"Kang R, Chen R, Xie M, Cao L, Lotze MT, Tang D, Zeh HJ (2016) The Receptor for Advanced Glycation End Products Activates the AIM2 Inflammasome in Acute Pancreatitis. J Immunol 196(10):4331\u20134337","journal-title":"J Immunol"},{"issue":"17","key":"12245_CR86","doi-asserted-by":"publisher","first-page":"3533","DOI":"10.1111\/bph.15499","volume":"178","author":"LGXDWG W","year":"2021","unstructured":"W LGXDWG (2021) Acinar cell NLRP3 inflammasome and gasdermin D (GSDMD) activation mediates pyroptosis and systemic inflammation in acute pancreatitis. Br J Pharmacol 178(17):3533\u20133552","journal-title":"Br J Pharmacol"},{"key":"12245_CR87","doi-asserted-by":"crossref","unstructured":"C Z, X HNCW (2022) Y, G X, Y Z, Drug D, a Diosgenin Derive, Inhibits L-Arginine-Induced Acute Pancreatitis through Meditating GSDMD in the Endoplasmic Reticulum via the TXNIP\/HIF-1\u03b1 Pathway. Nutrients. ;14(13)","DOI":"10.3390\/nu14132591"},{"issue":"5\u20136","key":"12245_CR88","first-page":"920","volume":"29","author":"SLSLXG Y Z","year":"2024","unstructured":"Y Z SLSLXG (2024) hP-MSCs attenuate severe acute pancreatitis in mice via inhibiting NLRP3 inflammasome-mediated acinar cell pyroptosis. Apoptosis: Int J Program cell death 29(5\u20136):920\u2013933","journal-title":"Apoptosis: Int J Program cell death"},{"key":"12245_CR89","doi-asserted-by":"crossref","unstructured":"Q YLBLMW, L Z (2023) G, N M, HDL inhibits pancreatic acinar cell NLRP3 inflammasome activation and protect against acinar cell pyroptosis in acute pancreatitis. Int Immunopharmacol. ;125(Pt A):110950.","DOI":"10.1016\/j.intimp.2023.110950"},{"issue":"2","key":"12245_CR90","doi-asserted-by":"publisher","first-page":"112634","DOI":"10.1016\/j.yexcr.2021.112634","volume":"404","author":"CX Li","year":"2021","unstructured":"Li CX, Cui LH, Zhang LQ, Yang L, Zhuo YZ, Cui NQ, Zhang SK (2021) Role of NLR family pyrin domain-containing 3 inflammasome in the activation of pancreatic stellate cells. Exp Cell Res 404(2):112634","journal-title":"Exp Cell Res"},{"issue":"8","key":"12245_CR91","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1142\/S0192415X21500944","volume":"49","author":"LT G Z","year":"2021","unstructured":"G Z LT (2021) Psidium guajava Flavonoids Prevent NLRP3 Inflammasome Activation and Alleviate the Pancreatic Fibrosis in a Chronic Pancreatitis Mouse Model. Am J Chin Med 49(8):2001\u20132015","journal-title":"Am J Chin Med"},{"key":"12245_CR92","doi-asserted-by":"crossref","unstructured":"L Y LCCLYZ (2020) N C, Y L, S Z. Saikosaponin A inhibits the activation of pancreatic stellate cells by suppressing autophagy and the NLRP3 inflammasome via the AMPK\/mTOR pathway, vol 128. Biomedicine & pharmacotherapy\u2009=\u2009Biomedecine & pharmacotherapie, p 110216","DOI":"10.1016\/j.biopha.2020.110216"},{"issue":"1","key":"12245_CR93","doi-asserted-by":"publisher","first-page":"eadq5786","DOI":"10.1126\/sciadv.adq5786","volume":"11","author":"SWGGXL C","year":"2025","unstructured":"C SWGGXL (2025) NLRP3 inflammasome constrains liver regeneration through impairing MerTK-mediated macrophage efferocytosis. Sci Adv 11(1):eadq5786","journal-title":"Sci Adv"},{"issue":"9","key":"12245_CR94","doi-asserted-by":"publisher","first-page":"7516","DOI":"10.1021\/acs.jmedchem.4c00357","volume":"67","author":"M Zhao","year":"2024","unstructured":"Zhao M, Ye N, Liu L, Zhang RJ, Li N, Peng J et al (2024) Novel Isoalantolactone-Based Derivatives as Potent NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization. J Med Chem 67(9):7516\u20137538","journal-title":"J Med Chem"},{"issue":"6","key":"12245_CR95","doi-asserted-by":"publisher","first-page":"eadi9284","DOI":"10.1126\/sciadv.adi9284","volume":"10","author":"XJ X Z","year":"2024","unstructured":"X Z XJ (2024) NU6300 covalently reacts with cysteine-191 of gasdermin D to block its cleavage and palmitoylation. Sci Adv 10(6):eadi9284","journal-title":"Sci Adv"},{"issue":"8","key":"12245_CR96","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1038\/s41401-023-01054-1","volume":"44","author":"W HY","year":"2023","unstructured":"HY W, GG XL, SY HRZ (2023) Atranorin inhibits NLRP3 inflammasome activation by targeting ASC and protects NLRP3 inflammasome-driven diseases. Acta Pharmacol Sin 44(8):1687\u20131700","journal-title":"Acta Pharmacol Sin"},{"issue":"7","key":"12245_CR97","doi-asserted-by":"publisher","first-page":"7243","DOI":"10.1021\/acs.jmedchem.4c02813","volume":"68","author":"YL Q","year":"2025","unstructured":"Q YL, C WJMJL (2025) Discovery of Novel Sulfonylurea NLRP3 Inflammasome Inhibitor for the Treatment of Multiple Inflammatory Diseases. J Med Chem 68(7):7243\u20137262","journal-title":"J Med Chem"},{"issue":"8","key":"12245_CR98","doi-asserted-by":"publisher","first-page":"nwad179","DOI":"10.1093\/nsr\/nwad179","volume":"10","author":"JLLD YM","year":"2023","unstructured":"YM JLLD (2023) Nickle-cobalt alloy nanocrystals inhibit activation of inflammasomes. Natl Sci Rev 10(8):nwad179","journal-title":"Natl Sci Rev"},{"key":"12245_CR99","doi-asserted-by":"publisher","first-page":"1150879","DOI":"10.3389\/fimmu.2023.1150879","volume":"14","author":"J Wang","year":"2023","unstructured":"Wang J, Sun Z, Xie J, Ji W, Cui Y, Ai Z, Liang G (2023) Inflammasome and pyroptosis in autoimmune liver diseases. Front Immunol 14:1150879","journal-title":"Front Immunol"},{"issue":"17","key":"12245_CR100","doi-asserted-by":"publisher","first-page":"3533","DOI":"10.1111\/bph.15499","volume":"178","author":"L Gao","year":"2021","unstructured":"Gao L, Dong X, Gong W, Huang W, Xue J, Zhu Q et al (2021) Acinar cell NLRP3 inflammasome and gasdermin D (GSDMD) activation mediates pyroptosis and systemic inflammation in acute pancreatitis. Br J Pharmacol 178(17):3533\u20133552","journal-title":"Br J Pharmacol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12245-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12245-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12245-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:52:54Z","timestamp":1783011174000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12245-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":100,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12245"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12245-4","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,2]]},"assertion":[{"value":"31 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1074"}}