{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:00:28Z","timestamp":1782860428323,"version":"3.54.5"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12261-4","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:20:35Z","timestamp":1782858035000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated analysis of UGT1A1 promoter polymorphism, gene expression, and IL-1\u03b2 reveals genotype-driven susceptibility in Gilbert syndrome"],"prefix":"10.1007","volume":"53","author":[{"given":"Sahar M.","family":"Hussein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roya Hadi","family":"Al-Haddad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saja Ali","family":"Shareef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mays Talib","family":"Abdallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"issue":"3","key":"12261_CR1","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/pr.2015.247","volume":"79","author":"N Memon","year":"2016","unstructured":"Memon N, Weinberger BI, Hegyi T, Aleksunes LM (2016) Inherited disorders of bilirubin clearance. Pediatr Res 79(3):378\u2013386","journal-title":"Pediatr Res"},{"issue":"1","key":"12261_CR2","doi-asserted-by":"publisher","first-page":"83","DOI":"10.14218\/jcth.2025.00440","volume":"14","author":"S Zheng","year":"2026","unstructured":"Zheng S, Xu X, Nan Y, Hou W, Bai J, Tang S et al (2026) Expert consensus on the diagnosis and management of inherited hyperbilirubinemia (2025). J Clin Translational Hepatol 14(1):83\u201395. https:\/\/doi.org\/10.14218\/jcth.2025.00440","journal-title":"J Clin Translational Hepatol"},{"issue":"1","key":"12261_CR3","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s12876-019-0931-2","volume":"19","author":"S Kamal","year":"2019","unstructured":"Kamal S, Abdelhakam S, Ghoraba D, Massoud Y, Aziz KA, Hassan H et al (2019) The frequency, clinical course, and health related quality of life in adults with Gilbert\u2019s syndrome: a longitudinal study. BMC Gastroenterol 19(1):22","journal-title":"BMC Gastroenterol"},{"key":"12261_CR4","doi-asserted-by":"crossref","unstructured":"Fariba H, Forugh S, Nasrin S, Mahmood H (2010) Gilbert syndrome in Iran, Fars province 30(1):84.","DOI":"10.5144\/0256-4947.59376"},{"key":"12261_CR5","doi-asserted-by":"publisher","unstructured":"Al-kuraishy HM, Al-Gareeb AI, Abdullah SM, Cruz-Martins N, Batiha GE-S (2021) Case report: hyperbilirubinemia in gilbert syndrome attenuates covid-19-induced metabolic disturbances. Front Cardiovasc Med 8:642181. https:\/\/doi.org\/10.3389\/fcvm.2021.642181","DOI":"10.3389\/fcvm.2021.642181"},{"issue":"18","key":"12261_CR6","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1056\/NEJM199511023331802","volume":"333","author":"PJ Bosma","year":"1995","unstructured":"Bosma PJ, Chowdhury JR, Bakker C, Gantla S, de Boer A, Oostra BA et al (1995) The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert\u2019s syndrome. N Engl J Med 333(18):1171\u20131175","journal-title":"N Engl J Med"},{"issue":"1","key":"12261_CR7","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1146\/annurev.pharmtox.40.1.581","volume":"40","author":"RH Tukey","year":"2000","unstructured":"Tukey RH, Strassburg CP (2000) Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol 40(1):581\u2013616","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"1","key":"12261_CR8","doi-asserted-by":"publisher","first-page":"59","DOI":"10.2478\/bjmg-2018-0012","volume":"21","author":"M Vukovic","year":"2018","unstructured":"Vukovic M, Radlovic N, Lekovic Z, Vucicevic K, Maric N, Kotur N et al (2018) UGT1A1 (TA) n promoter genotype: diagnostic and population pharmacogenetic marker in Serbia. Balkan J Med Genetics: BJMG 21(1):59","journal-title":"Balkan J Med Genetics: BJMG"},{"key":"12261_CR9","doi-asserted-by":"crossref","unstructured":"Chowdhury NR, Li Y, Chowdhury JR (2020) Disorders of bilirubin metabolism. The liver: biology and pathobiology. :229\u2009\u2013\u200944","DOI":"10.1002\/9781119436812.ch20"},{"issue":"09","key":"12261_CR10","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.3390\/antiox10091474","volume":"10","author":"K-H Wagner","year":"2021","unstructured":"Wagner K-H, Seyed Khoei N, Hana CA, Doberer D, Marculescu R, Bulmer AC et al (2021) Oxidative stress and related biomarkers in Gilbert\u2019s syndrome: A secondary analysis of two case-control studies. Antioxidants 10(09):1474","journal-title":"Antioxidants"},{"key":"12261_CR11","doi-asserted-by":"publisher","first-page":"115204","DOI":"10.1016\/j.bcp.2022.115204","volume":"203","author":"Y Li","year":"2022","unstructured":"Li Y, Sheng H, Yan Z, Guan B, Qiang S, Qian J et al (2022) Bilirubin stabilizes the mitochondrial membranes during NLRP3 inflammasome activation. Biochem Pharmacol 203:115204. https:\/\/doi.org\/10.1016\/j.bcp.2022.115204","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"12261_CR12","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/imr.12621","volume":"281","author":"CA Dinarello","year":"2018","unstructured":"Dinarello CA (2018) Overview of the IL-1 family in innate inflammation and acquired immunity. Immunol Rev 281(1):8\u201327","journal-title":"Immunol Rev"},{"issue":"8","key":"12261_CR13","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.3390\/antiox12081525","volume":"12","author":"JP Llido","year":"2023","unstructured":"Llido JP, Jayanti S, Tiribelli C, Gazzin S (2023) Bilirubin and redox stress in age-related brain diseases. Antioxidants 12(8):1525","journal-title":"Antioxidants"},{"key":"12261_CR14","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1161\/01.CIR.0000082641.20034.6A","volume":"108","author":"S Grundy","year":"2003","unstructured":"Grundy S, Inflammation (2003) Metabolic syndrome, and diet responsiveness. Circulation 108:126\u2013128. https:\/\/doi.org\/10.1161\/01.CIR.0000082641.20034.6A","journal-title":"Circulation"},{"issue":"1","key":"12261_CR15","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1002\/cpt.1651","volume":"107","author":"MV Relling","year":"2020","unstructured":"Relling MV, Klein TE, Gammal RS, Whirl-Carrillo M, Hoffman JM, Caudle KE (2020) The clinical pharmacogenetics implementation consortium: 10 years later. Clin Pharmacol Ther 107(1):171\u2013175. https:\/\/doi.org\/10.1002\/cpt.1651","journal-title":"Clin Pharmacol Ther"},{"key":"12261_CR16","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.redox.2015.06.008","volume":"5","author":"G Idelman","year":"2015","unstructured":"Idelman G, Smith DLH, Zucker SD (2015) Bilirubin inhibits the up-regulation of inducible nitric oxide synthase by scavenging reactive oxygen species generated by the toll-like receptor 4-dependent activation of NADPH oxidase. Redox Biol 5:398\u2013408. https:\/\/doi.org\/10.1016\/j.redox.2015.06.008","journal-title":"Redox Biol"},{"issue":"4","key":"12261_CR17","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/s41390-019-0451-3","volume":"86","author":"C He","year":"2019","unstructured":"He C, Feng J, Huang H, Hua Z (2019) Caspase-1 involves in bilirubin-induced injury of cultured rat cortical neurons. Pediatr Res 86(4):492\u2013499. https:\/\/doi.org\/10.1038\/s41390-019-0451-3","journal-title":"Pediatr Res"},{"key":"12261_CR18","doi-asserted-by":"publisher","first-page":"106520","DOI":"10.1016\/j.intimp.2020.106520","volume":"84","author":"Y Li","year":"2020","unstructured":"Li Y, Huang B, Ye T, Wang Y, Xia D, Qian J (2020) Physiological concentrations of bilirubin control inflammatory response by inhibiting NF-\u03baB and inflammasome activation. Int Immunopharmacol 84:106520. https:\/\/doi.org\/10.1016\/j.intimp.2020.106520","journal-title":"Int Immunopharmacol"},{"issue":"5","key":"12261_CR19","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1086\/302114","volume":"63","author":"DM Nielsen","year":"1998","unstructured":"Nielsen DM, Ehm MG, Weir BS (1998) Detecting marker-disease association by testing for hardy-weinberg disequilibrium at a marker locus. Am J Hum Genet 63(5):1531\u20131540. https:\/\/doi.org\/10.1086\/302114","journal-title":"Am J Hum Genet"},{"issue":"23","key":"12261_CR20","doi-asserted-by":"publisher","first-page":"14880","DOI":"10.3390\/ijms232314880","volume":"23","author":"R Gramignoli","year":"2022","unstructured":"Gramignoli R, Ranade AR, Venkataramanan R, Strom SC (2022) Effects of pro-inflammatory cytokines on hepatic metabolism in primary human hepatocytes. Int J Mol Sci 23(23):14880","journal-title":"Int J Mol Sci"},{"key":"12261_CR21","doi-asserted-by":"publisher","unstructured":"Duez H, Pourcet B (2021) Nuclear Receptors in the Control of the NLRP3 Inflammasome Pathway. Front Endocrinol 12:630536 https:\/\/doi.org\/10.3389\/fendo.2021.630536","DOI":"10.3389\/fendo.2021.630536"},{"issue":"2","key":"12261_CR22","doi-asserted-by":"publisher","first-page":"83","DOI":"10.2133\/dmpk.DMPK-12-RV-096","volume":"28","author":"J Sugatani","year":"2013","unstructured":"Sugatani J (2013) Function, genetic polymorphism, and transcriptional regulation of human UDP-glucuronosyltransferase (UGT) 1A1. Drug Metab Pharmacokinet 28(2):83\u201392","journal-title":"Drug Metab Pharmacokinet"},{"issue":"7","key":"12261_CR23","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1053\/j.gastro.2014.03.047","volume":"146","author":"S Erlinger","year":"2014","unstructured":"Erlinger S, Arias IM, Dhumeaux D (2014) Inherited disorders of bilirubin transport and conjugation: new insights into molecular mechanisms and consequences. Gastroenterology 146(7):1625\u20131638","journal-title":"Gastroenterology"},{"issue":"7","key":"12261_CR24","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1002\/kjm2.12077","volume":"35","author":"MJ Huang","year":"2019","unstructured":"Huang MJ, Chen YC, Huang YY, Yang SS, Chen PL, Huang CS (2019) Effect of UDP-glucuronosyltransferase 1A1 activity on risk for developing Gilbert\u2019s syndrome. Kaohsiung J Med Sci 35(7):432\u2013439","journal-title":"Kaohsiung J Med Sci"},{"issue":"8","key":"12261_CR25","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1200\/JCO.2004.07.173","volume":"22","author":"F Innocenti","year":"2004","unstructured":"Innocenti F, Undevia SD, Iyer L, Xian Chen P, Das S, Kocherginsky M et al (2004) Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan. J Clin Oncol 22(8):1382\u20131388","journal-title":"J Clin Oncol"},{"key":"12261_CR26","doi-asserted-by":"crossref","unstructured":"Fujiwara R, Chen S, Karin M, Tukey RH. Reduced Expression of UGT1A1 in Intestines of Humanized\u2009<\u2009em>UGT1 Mice via Inactivation of NF-\u03baB Leads to Hyperbilirubinemia.Gastroenterology. 2012;142(1):109\u2009\u2013\u200918.e2. doi: 10.1053\/j.gastro.2011.09.045","DOI":"10.1053\/j.gastro.2011.09.045"},{"key":"12261_CR27","unstructured":"Singh A, Koritala T, Jialal I (2021) Unconjugated Hyperbilirubinemia"},{"issue":"6","key":"12261_CR28","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s00439-004-1183-x","volume":"115","author":"Y Maruo","year":"2004","unstructured":"Maruo Y, D\u2032 Addario C, Mori A, Iwai M, Takahashi H, Sato H et al (2004) Two linked polymorphic mutations (A(TA)7TAA and T-3279G) of UGT1A1 as the principal cause of Gilbert syndrome. Hum Genet 115(6):525\u2013526. https:\/\/doi.org\/10.1007\/s00439-004-1183-x","journal-title":"Hum Genet"},{"issue":"6","key":"12261_CR29","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.1007\/s11033-018-4305-6","volume":"45","author":"AS Chiddarwar","year":"2018","unstructured":"Chiddarwar AS, D\u2019Silva SZ, Colah RB, Ghosh K, Mukherjee MB (2018) Genetic lesions in the UGT1A1 genes among Gilbert\u2019s syndrome patients from India. Mol Biol Rep 45(6):2733\u20132739. https:\/\/doi.org\/10.1007\/s11033-018-4305-6","journal-title":"Mol Biol Rep"},{"issue":"1","key":"12261_CR30","first-page":"25","volume":"26","author":"VE Radoi","year":"2017","unstructured":"Radoi VE, Ursu RI, Poenaru E, Arsene C, Bohiltea CL, Bohiltea R (2017) Frequency of the UGT1A1* 28 polymorphism in a Romanian cohort of Gilbert syndrome individuals. J Gastrointest Liver Dis 26(1):25\u201328","journal-title":"J Gastrointest Liver Dis"},{"issue":"14","key":"12261_CR31","doi-asserted-by":"publisher","first-page":"8170","DOI":"10.1073\/pnas.95.14.8170","volume":"95","author":"E Beutler","year":"1998","unstructured":"Beutler E, Gelbart T, Demina A (1998) Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism? Proc Natl Acad Sci 95(14):8170\u20138174","journal-title":"Proc Natl Acad Sci"},{"issue":"4","key":"12261_CR32","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1002\/1098-1004(200010)16:4<297::AID-HUMU2>3.0.CO;2-Z","volume":"16","author":"A Kadakol","year":"2000","unstructured":"Kadakol A, Ghosh SS, Sappal BS, Sharma G, Chowdhury JR, Chowdhury NR (2000) Genetic lesions of bilirubin uridine-diphosphoglucuronate glucuronosyltransferase (UGT1A1) causing Crigler\u2010Najjar and Gilbert syndromes: correlation of genotype to phenotype. Hum Mutat 16(4):297\u2013306","journal-title":"Hum Mutat"},{"key":"12261_CR33","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/S0300-483X(02)00449-3","volume":"181","author":"JO Miners","year":"2002","unstructured":"Miners JO, McKinnon RA, Mackenzie PI (2002) Genetic polymorphisms of UDP-glucuronosyltransferases and their functional significance. Toxicology 181:453\u2013456","journal-title":"Toxicology"},{"issue":"1","key":"12261_CR34","doi-asserted-by":"publisher","first-page":"37","DOI":"10.2165\/00129785-200303010-00006","volume":"3","author":"B Burchell","year":"2003","unstructured":"Burchell B (2003) Genetic Variation of Human UDP-Glucuronosyltransferase. Am J Pharmacogenomics 3(1):37\u201352. https:\/\/doi.org\/10.2165\/00129785-200303010-00006","journal-title":"Am J Pharmacogenomics"},{"issue":"4","key":"12261_CR35","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1111\/j.1742-7843.2006.pto_341.x","volume":"98","author":"MO Babaoglu","year":"2006","unstructured":"Babaoglu MO, Yigit S, Aynacioglu AS, Kerb R, Yurdakok M, Bozkurt A (2006) Neonatal jaundice and bilirubin UDP-glucuronosyl transferase 1A1 gene polymorphism in Turkish patients. Basic Clin Pharmacol Toxicol 98(4):377\u2013380","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"4","key":"12261_CR36","doi-asserted-by":"publisher","first-page":"372","DOI":"10.5144\/0256-4947.2013.372","volume":"33","author":"Z Hamad","year":"2013","unstructured":"Hamad Z, Aljedai A, Halwani R, AlSultan A (2013) UGT1A1 promoter polymorphism associated with serum bilirubin level in Saudi patients with sickle cell disease. Ann Saudi Med 33(4):372\u2013376","journal-title":"Ann Saudi Med"},{"key":"12261_CR37","unstructured":"Kaveh M, Esmailnia T, Nayeri F, Nili F, Tanha FD, Ghajarzdeh M (2013) UDP-glucuronosyltransferase promoter polymorphism in Iranian neonates with idiopathic hyperbilirubinemia. Acta Medica Iranica 51(11):789\u2013792"},{"issue":"4","key":"12261_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5812\/ircmj.44363","volume":"19","author":"MR Heydari","year":"2024","unstructured":"Heydari MR, Fardaei M, Kadivar MR, Rezaianzadeh A, Panjehshahin MR, Gholami Bardeji Z et al (2024) Prevalence of 2 UGT1A1 Gene Variations Related to Gilbert\u2019s Syndrome in South of Iran: An Epidemiological, Clinical, and Genetic Study. Iran Red Crescent Med J (IRCMJ) 19(4):1\u20137. https:\/\/doi.org\/10.5812\/ircmj.44363","journal-title":"Iran Red Crescent Med J (IRCMJ)"},{"key":"12261_CR39","doi-asserted-by":"publisher","unstructured":"Espinar L, Schikora Tamarit M\u00c0, Domingo J, Carey LB Promoter architecture determines cotranslational regulation of mRNA. Genome Res. 28(4):509\u2013518. https:\/\/doi.org\/10.1101\/gr.230458.117","DOI":"10.1101\/gr.230458.117"},{"issue":"3","key":"12261_CR40","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/nri2725","volume":"10","author":"J Tschopp","year":"2010","unstructured":"Tschopp J, Schroder K (2010) NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? Nat Rev Immunol 10(3):210\u2013215","journal-title":"Nat Rev Immunol"},{"issue":"7329","key":"12261_CR41","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nature09663","volume":"469","author":"R Zhou","year":"2011","unstructured":"Zhou R, Yazdi AS, Menu P, Tschopp J (2011) A role for mitochondria in NLRP3 inflammasome activation. Nature 469(7329):221\u2013225","journal-title":"Nature"},{"issue":"7","key":"12261_CR42","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/nm.3893","volume":"21","author":"H Guo","year":"2015","unstructured":"Guo H, Callaway JB, Ting JP (2015) Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med 21(7):677\u2013687","journal-title":"Nat Med"},{"issue":"7","key":"12261_CR43","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nri.2016.58","volume":"16","author":"P Broz","year":"2016","unstructured":"Broz P, Dixit VM (2016) Inflammasomes: mechanism of assembly, regulation and signalling. Nat Rev Immunol 16(7):407\u2013420","journal-title":"Nat Rev Immunol"},{"issue":"8","key":"12261_CR44","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","volume":"19","author":"KV Swanson","year":"2019","unstructured":"Swanson KV, Deng M, Ting JP-Y (2019) The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat Rev Immunol 19(8):477\u2013489","journal-title":"Nat Rev Immunol"},{"key":"12261_CR45","doi-asserted-by":"publisher","first-page":"145526","DOI":"10.1016\/j.gene.2021.145526","volume":"781","author":"M Zhang","year":"2021","unstructured":"Zhang M, Wang H, Huang Y, Xu X, Liu W, Ning Q et al (2021) Compound heterozygous UGT1A1* 28 and UGT1A1* 6 or single homozygous UGT1A1* 28 are major genotypes associated with Gilbert\u2019s syndrome in Chinese Han people. Gene 781:145526","journal-title":"Gene"},{"issue":"9","key":"12261_CR46","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1111\/eci.12120","volume":"43","author":"M Wallner","year":"2013","unstructured":"Wallner M, Bulmer AC, M\u00f6lzer C, M\u00fcllner E, Marculescu R, Doberer D et al (2013) Haem catabolism: a novel modulator of inflammation in G ilbert\u2019s syndrome. Eur J Clin Invest 43(9):912\u2013919","journal-title":"Eur J Clin Invest"},{"issue":"10","key":"12261_CR47","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1046\/j.1440-1746.1999.01984.x","volume":"14","author":"B Burchell","year":"1999","unstructured":"Burchell B, Hume R (1999) Molecular genetic basis of Gilbert\u2019s syndrome. J Gastroenterol Hepatol 14(10):960\u2013966","journal-title":"J Gastroenterol Hepatol"},{"issue":"1","key":"12261_CR48","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S (2000) KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28(1):27\u201330","journal-title":"Nucleic Acids Res"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12261-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12261-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12261-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:20:48Z","timestamp":1782858048000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12261-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12261"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12261-4","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]},"assertion":[{"value":"19 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Approved by the Scientific Research Commission, Baghdad, Iraq (SRC\/115\/0008). Written informed consent was obtained in accordance with the Declaration of Helsinki.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"1035"}}