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The study was conducted in accordance with the National Institutes of Health (NIH) Guide for the Care and Use of Laboratory Animals and complied with relevant institutional and international ethical guidelines. As this study did not involve human participants or identifiable human data, informed consent to participate was not required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1151"}}