{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T07:04:09Z","timestamp":1784358249579,"version":"3.55.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Vice-Chancellor for Research Affairs of Shiraz University of Medical Sciences","award":["30994"],"award-info":[{"award-number":["30994"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12360-2","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:50:03Z","timestamp":1784357403000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrative analysis identifies candidate biomarkers for bladder cancer: evidence from genomic and clinical validation"],"prefix":"10.1007","volume":"53","author":[{"given":"Sana","family":"Sajjadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5655-8722","authenticated-orcid":false,"given":"Amin","family":"Ramezani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajad","family":"Alavimanesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hojat","family":"Alipoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0246-3765","authenticated-orcid":false,"given":"Mohammad Ali","family":"Takhshid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"key":"12360_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-025-01122-7","author":"H Al-Sattar","year":"2026","unstructured":"Al-Sattar H et al (2026) A multi-modal approach for decision making in bladder cancer. Nat Rev Urol. https:\/\/doi.org\/10.1038\/s41585-025-01122-7","journal-title":"Nat Rev Urol"},{"issue":"1","key":"12360_CR2","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/s41572-023-00468-9","volume":"9","author":"L Dyrskj\u00f8t","year":"2023","unstructured":"Dyrskj\u00f8t L et al (2023) Bladder cancer. Nat Rev Dis Primers 9(1):58","journal-title":"Nat Rev Dis Primers"},{"issue":"5","key":"12360_CR3","doi-asserted-by":"publisher","first-page":"4339","DOI":"10.1007\/s11033-023-08370-z","volume":"50","author":"FZ El Sharkawi","year":"2023","unstructured":"El Sharkawi FZ et al (2023) Urinary BLACAT1 as a non-invasive biomarker for bladder cancer. Mol Biol Rep 50(5):4339\u20134345","journal-title":"Mol Biol Rep"},{"key":"12360_CR4","doi-asserted-by":"publisher","first-page":"1546160","DOI":"10.3389\/fonc.2025.1546160","volume":"15","author":"G Attanasio","year":"2025","unstructured":"Attanasio G et al (2025) Histological and immunohistochemical approaches to molecular subtyping in muscle-invasive bladder cancer. Front Oncol 15:1546160","journal-title":"Front Oncol"},{"issue":"3","key":"12360_CR5","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.annonc.2021.11.012","volume":"33","author":"T Powles","year":"2022","unstructured":"Powles T et al (2022) Bladder cancer: ESMO clinical practice guideline for diagnosis, treatment and follow-up\u2606. Ann Oncol 33(3):244\u2013258","journal-title":"Ann Oncol"},{"issue":"10","key":"12360_CR6","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/s41585-023-00773-8","volume":"20","author":"M Maas","year":"2023","unstructured":"Maas M, Todenh\u00f6fer T, Black PC (2023) Urine biomarkers in bladder cancer\u2014current status and future perspectives. Nat Rev Urol 20(10):597\u2013614","journal-title":"Nat Rev Urol"},{"issue":"9","key":"12360_CR7","volume":"17","author":"O Enemoh","year":"2025","unstructured":"Enemoh O et al (2025) Exploring the need for a consensus guideline for the management of non-muscle-invasive bladder cancer: a scoping review. Cureus 17(9):e93553","journal-title":"Cureus"},{"key":"12360_CR8","doi-asserted-by":"crossref","unstructured":"Abbas, S., et al., AI predicting recurrence in non-muscle-invasive bladder cancer: systematic review with study strengths and weaknesses. Frontiers in Oncology, 2025. Volume 14 - 2024.","DOI":"10.3389\/fonc.2024.1509362"},{"issue":"13","key":"12360_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22137201","volume":"22","author":"I-H Kim","year":"2021","unstructured":"Kim I-H, Lee H-J (2021) Perioperative systemic treatment for muscle-invasive bladder cancer: current evidence and future perspectives. Int J Mol Sci 22(13):7201","journal-title":"Int J Mol Sci"},{"key":"12360_CR10","first-page":"1089463","volume-title":"Application of systems biology in molecular characterization and diagnosis of cancer, volume II","author":"Y Wei","year":"2022","unstructured":"Wei Y et al (2022) Application of systems biology in molecular characterization and diagnosis of cancer, volume II. Frontiers Media SA, p 1089463"},{"key":"12360_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.1000847","volume":"9","author":"Q Gao","year":"2022","unstructured":"Gao Q et al (2022) Identification of the hub and prognostic genes in liver hepatocellular carcinoma via bioinformatics analysis. Front Mol Biosci 9:1000847","journal-title":"Front Mol Biosci"},{"issue":"1","key":"12360_CR12","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/nar\/30.1.207","volume":"30","author":"R Edgar","year":"2002","unstructured":"Edgar R, Domrachev M, Lash AE (2002) Gene expression omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 30(1):207\u2013210","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"12360_CR13","doi-asserted-by":"publisher","first-page":"D138","DOI":"10.1093\/nar\/gkad965","volume":"52","author":"E Clough","year":"2024","unstructured":"Clough E et al (2024) NCBI GEO: archive for gene expression and epigenomics data sets: 23-year update. Nucleic Acids Res 52(D1):D138\u2013D144","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"12360_CR14","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15(12):550","journal-title":"Genome Biol"},{"issue":"1","key":"12360_CR15","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s10142-021-00821-9","volume":"22","author":"F Almeida-Silva","year":"2022","unstructured":"Almeida-Silva F, Venancio TM (2022) BioNERO: an all-in-one R\/Bioconductor package for comprehensive and easy biological network reconstruction. Funct Integr Genomics 22(1):131\u2013136","journal-title":"Funct Integr Genomics"},{"issue":"3","key":"12360_CR16","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.90","volume":"1","author":"Z Xie","year":"2021","unstructured":"Xie Z et al (2021) Gene set knowledge discovery with Enrichr. Curr Protoc 1(3):e90","journal-title":"Curr Protoc"},{"issue":"W1","key":"12360_CR17","doi-asserted-by":"publisher","first-page":"W90","DOI":"10.1093\/nar\/gkw377","volume":"44","author":"MV Kuleshov","year":"2016","unstructured":"Kuleshov MV et al (2016) Enrichr: a comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Res 44(W1):W90\u2013W97","journal-title":"Nucleic Acids Res"},{"key":"12360_CR18","doi-asserted-by":"crossref","unstructured":"The Gene Ontology knowledgebase in 2026. Nucleic Acids Research, 2026. 54(D1): p. D1779\u2013D1792.","DOI":"10.1093\/nar\/gkag678"},{"key":"12360_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2021.106267","volume":"187","author":"A Ramezani","year":"2021","unstructured":"Ramezani A (2021) CtNorm: real time PCR cycle of threshold (Ct) normalization algorithm. J Microbiol Methods 187:106267","journal-title":"J Microbiol Methods"},{"issue":"9","key":"12360_CR20","doi-asserted-by":"publisher","first-page":"7867","DOI":"10.1007\/s11033-023-08689-7","volume":"50","author":"L Schwarzova","year":"2023","unstructured":"Schwarzova L et al (2023) Molecular classification of urothelial bladder carcinoma. Mol Biol Rep 50(9):7867\u20137877","journal-title":"Mol Biol Rep"},{"key":"12360_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1537808","volume":"16","author":"P Huang","year":"2025","unstructured":"Huang P et al (2025) Redefining bladder cancer treatment: innovations in overcoming drug resistance and immune evasion. Front Immunol 16:1537808","journal-title":"Front Immunol"},{"issue":"24","key":"12360_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16244125","volume":"16","author":"JE Matloubieh","year":"2024","unstructured":"Matloubieh JE, Hanelin D, Agalliu I (2024) Comparisons of intravesical treatments with mitomycin C, gemcitabine, and docetaxel for recurrence and progression of non-muscle invasive bladder cancer: updated systematic review and meta-analysis. Cancers 16(24):4125","journal-title":"Cancers"},{"key":"12360_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1453278","volume":"14","author":"M Ahangar","year":"2024","unstructured":"Ahangar M, Mahjoubi F, Mowla SJ (2024) Bladder cancer biomarkers: current approaches and future directions. Front Oncol 14:1453278","journal-title":"Front Oncol"},{"issue":"1","key":"12360_CR24","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s12894-022-01103-7","volume":"22","author":"T Fan","year":"2022","unstructured":"Fan T et al (2022) CDH1 overexpression predicts bladder cancer from early stage and inversely correlates with immune infiltration. BMC Urol 22(1):156","journal-title":"BMC Urol"},{"issue":"10","key":"12360_CR25","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1093\/carcin\/bgt187","volume":"34","author":"J Zhang","year":"2013","unstructured":"Zhang J et al (2013) Overexpression of Rab25 contributes to metastasis of bladder cancer through induction of epithelial-mesenchymal transition and activation of Akt\/GSK-3\u03b2\/Snail signaling. Carcinogenesis 34(10):2401\u20138","journal-title":"Carcinogenesis"},{"key":"12360_CR26","doi-asserted-by":"crossref","unstructured":"Su, M., et al., E2F1-induced transcriptional activation of MAL2 inhibits sunitinib sensitivity and promotes the malignant progression of bladder cancer. J Chemother, 2025: p. 1\u201312.","DOI":"10.1080\/1120009X.2025.2561275"},{"issue":"10","key":"12360_CR27","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202500423R","volume":"39","author":"Z Liu","year":"2025","unstructured":"Liu Z et al (2025) AP1M2 drives gemcitabine-cisplatin chemoresistance by enhancing RAD54B-associated DNA repair in bladder cancer. FASEB J 39(10):e70595","journal-title":"FASEB J"},{"key":"12360_CR28","doi-asserted-by":"crossref","unstructured":"Zhang, S., et al., Identification of Prognostic Biomarkers for Bladder Cancer Based on DNA Methylation Profile. Frontiers in Cell and Developmental Biology, 2022. Volume 9 - 2021.","DOI":"10.3389\/fcell.2021.817086"},{"issue":"9","key":"12360_CR29","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.3390\/cancers13092077","volume":"13","author":"DB Anton","year":"2021","unstructured":"Anton DB et al (2021) A special view of what was almost forgotten: p38\u03b4 MAPK. Cancers (Basel) 13(9):2077","journal-title":"Cancers (Basel)"},{"issue":"1","key":"12360_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-61302-0","volume":"14","author":"G Cheng","year":"2024","unstructured":"Cheng G et al (2024) Predicting bladder cancer survival with high accuracy: insights from MAPK pathway-related genes. Sci Rep 14(1):10482","journal-title":"Sci Rep"},{"issue":"6","key":"12360_CR31","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/j.bbalip.2018.07.006","volume":"1864","author":"N Kono","year":"2019","unstructured":"Kono N, Arai H (2019) Platelet-activating factor acetylhydrolases: an overview and update. Biochimica et Biophysica Acta (BBA) Mol Cell Biol Lipids 1864(6):922\u2013931","journal-title":"Biochimica et Biophysica Acta (BBA) Mol Cell Biol Lipids"},{"key":"12360_CR32","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.799497","volume":"8","author":"Y Yuan","year":"2022","unstructured":"Yuan Y et al (2022) Comprehensive analysis of the prognostic and immunological role of PAFAH1B in pan-cancer. Front Mol Biosci 8:799497","journal-title":"Front Mol Biosci"},{"issue":"9","key":"12360_CR33","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.2174\/0929867330666230427102920","volume":"31","author":"W Jiang","year":"2024","unstructured":"Jiang W et al (2024) PAFAH1B3 regulates papillary thyroid carcinoma cell proliferation and metastasis by affecting the EMT. Curr Med Chem 31(9):1152\u20131164","journal-title":"Curr Med Chem"},{"issue":"7","key":"12360_CR34","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1021\/acschembio.5b00053","volume":"10","author":"RA Kohnz","year":"2015","unstructured":"Kohnz RA et al (2015) Activity-based protein profiling of oncogene-driven changes in metabolism reveals broad dysregulation of PAFAH1B2 and 1B3 in cancer. ACS Chem Biol 10(7):1624\u20131630","journal-title":"ACS Chem Biol"},{"key":"12360_CR35","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.591545","volume":"11","author":"T Xie","year":"2021","unstructured":"Xie T et al (2021) PAFAH1B3 expression is correlated with gastric cancer cell proliferation and immune infiltration. Front Oncol 11:591545","journal-title":"Front Oncol"},{"key":"12360_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.119251","volume":"305","author":"G Zhu","year":"2025","unstructured":"Zhu G, Tan C, Li Y (2025) Multi-omics integrative analysis of the mechanisms linking environmental pollutant exposure to bladder cancer pathogenesis. Ecotoxicol Environ Saf 305:119251","journal-title":"Ecotoxicol Environ Saf"},{"issue":"1","key":"12360_CR37","doi-asserted-by":"publisher","first-page":"8184","DOI":"10.1038\/s41467-024-52513-0","volume":"15","author":"H Zhang","year":"2024","unstructured":"Zhang H et al (2024) Structural basis of human 20S proteasome biogenesis. Nat Commun 15(1):8184","journal-title":"Nat Commun"},{"issue":"3","key":"12360_CR38","doi-asserted-by":"publisher","first-page":"583","DOI":"10.7150\/jca.126116","volume":"17","author":"S Kumar","year":"2026","unstructured":"Kumar S et al (2026) Proteasome assembly chaperone 3 defines metabolic-immune programs and poor prognosis in breast cancer via multi-omics approaches. J Cancer 17(3):583","journal-title":"J Cancer"},{"issue":"1","key":"12360_CR39","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s12094-024-03580-8","volume":"27","author":"M Zheng","year":"2025","unstructured":"Zheng M et al (2025) Comprehensive analysis of PSMG3 in pan-cancer and validation of its role in hepatocellular carcinoma. Clin Transl Oncol 27(1):319\u2013332","journal-title":"Clin Transl Oncol"},{"issue":"1","key":"12360_CR40","doi-asserted-by":"publisher","DOI":"10.1177\/15579883251410519","volume":"20","author":"G Shi","year":"2026","unstructured":"Shi G et al (2026) Harnessing ubiquitin-proteasome system-related genes to identify subtypes of bladder cancer and reveal immune landscape. Am J Mens Health 20(1):15579883251410519","journal-title":"Am J Mens Health"},{"issue":"5","key":"12360_CR41","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.urolonc.2020.02.002","volume":"38","author":"F Janisch","year":"2020","unstructured":"Janisch F et al (2020) The prognostic value of the urokinase-plasminogen activator system (uPA) in bladder cancer patients treated with radical cystectomy (RC). Urol Oncol 38(5):423\u2013432","journal-title":"Urol Oncol"},{"issue":"10","key":"12360_CR42","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/j.urolonc.2019.05.019","volume":"37","author":"T Iwata","year":"2019","unstructured":"Iwata T et al (2019) Prognostic role of the urokinase plasminogen activator (uPA) system in patients with nonmuscle invasive bladder cancer. Urol Oncol 37(10):774\u2013783","journal-title":"Urol Oncol"},{"key":"12360_CR43","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14238526","author":"M Asif","year":"2025","unstructured":"Asif M et al (2025) Diagnostic and prognostic implications of FGFR3, TP53 mutation and urinary biomarkers in urothelial carcinoma in Pakistani cohort. J Clin Med. https:\/\/doi.org\/10.3390\/jcm14238526","journal-title":"J Clin Med"},{"issue":"6","key":"12360_CR44","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1002\/dc.24954","volume":"50","author":"J Wang","year":"2022","unstructured":"Wang J et al (2022) Diagnostic performance of nuclear matrix protein 22 and urine cytology for bladder cancer: a meta\u2010analysis. Diagn Cytopathol 50(6):300\u2013312","journal-title":"Diagn Cytopathol"},{"issue":"1","key":"12360_CR45","doi-asserted-by":"publisher","first-page":"87","DOI":"10.7150\/ijms.78590","volume":"20","author":"DTM Xuan","year":"2023","unstructured":"Xuan DTM et al (2023) Prognostic and immune infiltration value of proteasome assembly chaperone (PSMG) family genes in lung adenocarcinoma. Int J Med Sci 20(1):87\u2013101","journal-title":"Int J Med Sci"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12360-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12360-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12360-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:50:05Z","timestamp":1784357405000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12360-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,18]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12360"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12360-2","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,18]]},"assertion":[{"value":"16 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Research Ethics Committee of Shiraz University of Medical Sciences (Approval ID: IR.SUMS.REC.1403.208).","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All eligible participants provided written informed consent before enrollment.","order":3,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1205"}}