{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:32:09Z","timestamp":1786365129009,"version":"build-2736575974"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12414-5","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:02:50Z","timestamp":1786363370000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["miR-26b-modified human umbilical cord mesenchymal stem cells exhibit enhanced anti-fibrotic efficacy in a mouse model of hepatic fibrosis"],"prefix":"10.1007","volume":"53","author":[{"given":"Jianwei","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuzhen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanhang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuxian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanxiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"issue":"8","key":"12414_CR1","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3390\/bioengineering8080106","volume":"8","author":"L Cacopardo","year":"2021","unstructured":"Cacopardo L, Ahluwalia A (2021) Engineering and monitoring 3D cell constructs with time-evolving viscoelasticity for the study of liver fibrosis in vitro[J]. Bioengineering 8(8):106","journal-title":"Bioengineering"},{"issue":"28","key":"12414_CR2","doi-asserted-by":"publisher","first-page":"25645","DOI":"10.1021\/acsnano.5c00985","volume":"19","author":"H Liu","year":"2025","unstructured":"Liu H, Qi Y, Wang L, Zhang Y, Chen H, Zhao Y, Min H, Nie G, Liang H (2025) Lysosome-Targeting Nanochimeras Attenuating Liver Fibrosis by Interconnected Transforming Growth Factor-\u03b2 Reduction and Activin Receptor-Like Kinase 5 Degradation. ACS Nano 19(28):25645\u201325661","journal-title":"ACS Nano"},{"key":"12414_CR3","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.actbio.2023.12.027","volume":"175","author":"X Wang","year":"2024","unstructured":"Wang X, Zhang W, Zeng S et al (2024) Collagenase type I and probucol-loaded nanoparticles penetrate the extracellular matrix to target hepatic stellate cells for hepatic fibrosis therapy[J]. Acta Biomater 175:262\u2013278","journal-title":"Acta Biomater"},{"issue":"1","key":"12414_CR4","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/s41420-023-01749-8","volume":"9","author":"JL Lu","year":"2023","unstructured":"Lu JL, Yu CX, Song LJ (2023) Programmed cell death in hepatic fibrosis: current and perspectives[J]. Cell Death Discovery 9(1):449","journal-title":"Cell Death Discovery"},{"issue":"1","key":"12414_CR5","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1186\/s13287-024-03849-3","volume":"15","author":"L Zheng","year":"2024","unstructured":"Zheng L, Chen W, Yao K et al (2024) Clinical and preclinical studies of mesenchymal stem cells to alleviate peritoneal fibrosis[J]. Stem Cell Res Ther 15(1):237","journal-title":"Stem Cell Res Ther"},{"issue":"2","key":"12414_CR6","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3350\/cmh.2024.0854","volume":"31","author":"L Li","year":"2024","unstructured":"Li L, Liu Y, Wang K et al (2024) Stem cell exosomes: new hope and future potential for relieving liver fibrosis[J]. Clin Mol Hepatol 31(2):333","journal-title":"Clin Mol Hepatol"},{"key":"12414_CR7","doi-asserted-by":"publisher","first-page":"609544","DOI":"10.3389\/fimmu.2021.609544","volume":"12","author":"S Zheng","year":"2021","unstructured":"Zheng S, Huang K, Xia W et al (2021) Mesenchymal stromal cells rapidly suppress TCR signaling-mediated cytokine transcription in activated T cells through the ICAM-1\/CD43 interaction[J]. Front Immunol 12:609544","journal-title":"Front Immunol"},{"issue":"6","key":"12414_CR8","doi-asserted-by":"publisher","first-page":"524","DOI":"10.3390\/bioengineering11060524","volume":"11","author":"MYG Arellano","year":"2024","unstructured":"Arellano MYG, VanHeest M, Emmadi S et al (2024) Role of mesenchymal stem\/stromal cells (MSCs) and MSC-derived extracellular vesicles (EVs) in prevention of telomere length shortening, cellular senescence, and accelerated biological aging[J]. Bioengineering 11(6):524","journal-title":"Bioengineering"},{"key":"12414_CR9","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.omtn.2020.03.010","volume":"20","author":"F Jiang","year":"2020","unstructured":"Jiang F, Zong Y, Ma X et al (2020) miR-26a attenuated bone-specific insulin resistance and bone quality in diabetic mice[J]. Mol Therapy Nucleic Acids 20:459\u2013467","journal-title":"Mol Therapy Nucleic Acids"},{"issue":"6","key":"12414_CR10","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1002\/jcb.25428","volume":"117","author":"A Zhu","year":"2016","unstructured":"Zhu A, Kang N, He L, Li X, Xu X, Zhang H (2016) MiR-221 and miR-26b Regulate Chemotactic Migration of MSCs Toward HGF Through Activation of Akt and FAK. J Cell Biochem 117(6):1370\u20131383","journal-title":"J Cell Biochem"},{"issue":"6","key":"12414_CR11","doi-asserted-by":"publisher","first-page":"181","DOI":"10.14715\/cmb\/2023.69.6.27","volume":"69","author":"Z Yingmin Mao","year":"2023","unstructured":"Yingmin Mao Z, Zeng HY et al (2023) LINC01094 accelerates the metastasis of hepatocellular carcinoma via the miR-26b-3p\/MDM4 axis [J]. Cell Mol Biol 69(6):181\u2013185","journal-title":"Cell Mol Biol"},{"issue":"1","key":"12414_CR12","doi-asserted-by":"publisher","first-page":"9470","DOI":"10.1038\/s41598-025-94364-9","volume":"15","author":"J Xu","year":"2025","unstructured":"Xu J, Dong L, Xie X, Geng BD, Lu J, Dong Y, Hu Y, Liu C, Mao Y, Ge G, Ren Z (2025) Human umbilical cord-derived mesenchymal stem cells improve thymus and spleen functions in D-galactose-induced aged mice. Sci Rep 15(1):9470","journal-title":"Sci Rep"},{"issue":"6","key":"12414_CR13","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1002\/jcb.25428","volume":"117","author":"A Zhu","year":"2016","unstructured":"Zhu A, Kang N, He L, Li X, Xu X, Zhang H (2016) MiR-221 and miR-26b regulate chemotactic migration of MSCs toward HGF through activation of Akt and FAK. J Cell Biochem 117(6):1370\u20131383","journal-title":"J Cell Biochem"},{"key":"12414_CR14","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402\u2013408","journal-title":"Methods"},{"issue":"1","key":"12414_CR15","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1002\/hep.1840030118","volume":"3","author":"R P\u00e9rez Tamayo","year":"1983","unstructured":"P\u00e9rez Tamayo R (1983) Is cirrhosis of the liver experimentally produced by CCl4 and adequate model of human cirrhosis? Hepatology (Baltimore MD) 3(1):112\u2013120","journal-title":"Hepatology (Baltimore MD)"},{"issue":"6","key":"12414_CR16","first-page":"203","volume":"6","author":"M Vohra","year":"2020","unstructured":"Vohra M, Sharma A, Bagga R et al (2020) Human umbilical cord-derived mesenchymal stem cells induce tissue repair and regeneration in collagen-induced arthritis in rats[J]. J Clin Translational Res 6(6):203","journal-title":"J Clin Translational Res"},{"issue":"5","key":"12414_CR17","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.3390\/cancers13051169","volume":"13","author":"Y Aguilera","year":"2021","unstructured":"Aguilera Y, Mellado-Damas N, Olmedo-Moreno L et al (2021) Preclinical safety evaluation of intranasally delivered human mesenchymal stem cells in juvenile mice. Cancers (Basel) 13(5):1169 [EB\/OL]","journal-title":"Cancers (Basel)"},{"issue":"1","key":"12414_CR18","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s13577-021-00646-5","volume":"35","author":"S Kumar","year":"2022","unstructured":"Kumar S, Verma R, Tyagi N, Gangenahalli G, Verma YK (2022) Therapeutics effect of mesenchymal stromal cells in reactive oxygen species-induced damages[J]. Hum Cell 35(1):37\u201350","journal-title":"Hum Cell"},{"issue":"1","key":"12414_CR19","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13287-018-0776-6","volume":"9","author":"T Xu","year":"2018","unstructured":"Xu T, Zhang Y, Chang P et al (2018) Mesenchymal stem cell-based therapy for radiation-induced lung injury[J]. Stem Cell Res Ther 9(1):18","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"12414_CR20","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1186\/s13287-025-04327-0","volume":"16","author":"L Chen","year":"2025","unstructured":"Chen L, Liu Y, Yu C et al (2025) Induced pluripotent stem cell-derived mesenchymal stem cells (iMSCs) inhibit M1 macrophage polarization and reduce alveolar bone loss associated with periodontitis[J]. Stem Cell Res Ther 16(1):223","journal-title":"Stem Cell Res Ther"},{"issue":"14","key":"12414_CR21","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.2174\/1568026621666210708092728","volume":"21","author":"X Zhu","year":"2021","unstructured":"Zhu X, Yan T, Cheng C et al (2021) Mesenchymal Stem Cells (MSCs) in targeted drug delivery: literature review and exploratory data on migrating and differentiation capacities of bone MSCs into hepatic progenitor cells[J]. Curr Top Med Chem 21(14):1251\u20131267","journal-title":"Curr Top Med Chem"},{"key":"12414_CR22","doi-asserted-by":"publisher","first-page":"096368972210869","DOI":"10.1177\/09636897221086971","volume":"31","author":"T Chen","year":"2022","unstructured":"Chen T, Zhang S, Jin H et al (2022) Nonfreezing low temperature maintains the viability of menstrual blood\u2013derived endometrial stem cells under oxygen\u2013glucose deprivation through the sustained release of autophagy-produced energy[J]. Cell Transplant 31:09636897221086971","journal-title":"Cell Transplant"},{"issue":"23","key":"12414_CR23","doi-asserted-by":"publisher","first-page":"2808","DOI":"10.1097\/CM9.0000000000003332","volume":"137","author":"L Zhang","year":"2024","unstructured":"Zhang L, Deng Y, Bai X et al (2024) Cell therapy for end-stage liver disease: Current state and clinical challenge[J]. Chin Med J 137(23):2808\u20132820","journal-title":"Chin Med J"},{"key":"12414_CR24","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.yexmp.2019.02.003","volume":"107","author":"H Hu","year":"2019","unstructured":"Hu H, Zhao C, Zhang P et al (2019) miR-26b modulates OA induced BMSC osteogenesis through regulating GSK3\u03b2\/\u03b2-catenin pathway[J]. Exp Mol Pathol 107:158\u2013164","journal-title":"Exp Mol Pathol"},{"issue":"8","key":"12414_CR25","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1007\/s13205-022-03222-2","volume":"12","author":"G He","year":"2022","unstructured":"He G, Liu X, Liu L (2022) microRNA-26b inhibits growth and cellular invasion of ovarian cancer cells by targeting estrogen receptor \u03b1. 3 Biotech 12(8):168","journal-title":"3 Biotech"},{"key":"12414_CR26","doi-asserted-by":"publisher","first-page":"106704","DOI":"10.1016\/j.phrs.2023.106704","volume":"189","author":"L Chen","year":"2023","unstructured":"Chen L, Xia S, Wang F et al (2023) m6A Methylation-induced NR1D1 ablation disrupts the HSC circadian clock and promotes hepatic Fibrosis [J]. Pharmacol Res 189:106704","journal-title":"Pharmacol Res"},{"issue":"2","key":"12414_CR27","doi-asserted-by":"publisher","first-page":"189086","DOI":"10.1016\/j.bbcan.2024.189086","volume":"1879","author":"YD Sun","year":"2024","unstructured":"Sun YD, Zhang H, Li YM, Han JJ (2024) Abnormal metabolism in hepatic stellate cells: Pandora's box of MAFLD related hepatocellular carcinoma. Biochim Biophys Acta Rev Cancer 1879(2):189086","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"12414_CR28","doi-asserted-by":"publisher","first-page":"125540","DOI":"10.1016\/j.ijbiomac.2023.125540","volume":"245","author":"X Ma","year":"2023","unstructured":"Ma X, Zhou W, Nie Y et al (2023) A novel branched galacturonan from Gardenia jasminoides alleviates liver fibrosis linked to TLR4\/NF-\u03baB Signaling [J]. Int J Biol Macromol 245:125540","journal-title":"Int J Biol Macromol"},{"key":"12414_CR29","doi-asserted-by":"publisher","first-page":"155502","DOI":"10.1016\/j.phymed.2024.155502","volume":"128","author":"Y Yao","year":"2024","unstructured":"Yao Y, Zuo X, Shao F et al (2024) Jaceosidin attenuates the progression of hepatic fibrosis by inhibiting the VGLL3\/HMGB1\/TLR4 signaling Pathway [J]. Phytomedicine 128:155502","journal-title":"Phytomedicine"},{"key":"12414_CR30","doi-asserted-by":"publisher","first-page":"604894","DOI":"10.3389\/fmed.2021.604894","volume":"8","author":"M Wan","year":"2021","unstructured":"Wan M, Han J, Ding L, Hu F, Gao P (2021) Novel immune subsets and related cytokines: emerging players in the progression of liver fibrosis. Front Med (Lausanne) 8:604894","journal-title":"Front Med (Lausanne)"},{"key":"12414_CR31","doi-asserted-by":"publisher","first-page":"156347","DOI":"10.1016\/j.cyto.2023.156347","volume":"170","author":"P Pratim Das","year":"2023","unstructured":"Pratim Das P, Medhi S (2023) Role of inflammasomes and cytokines in immune dysfunction of liver Cirrhosis [J]. Cytokine 170:156347","journal-title":"Cytokine"},{"key":"12414_CR32","doi-asserted-by":"publisher","first-page":"1147710","DOI":"10.3389\/fimmu.2023.1147710","volume":"14","author":"W Yu","year":"2023","unstructured":"Yu W, Wang S, Wang Y, Chen H, Nie H, Liu L, Zou X, Gong Q, Zheng B (2023) MicroRNA: role in macrophage polarization and the pathogenesis of the liver fibrosis. Front Immunol 14:1147710","journal-title":"Front Immunol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12414-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12414-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12414-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:02:51Z","timestamp":1786363371000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12414-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,10]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12414"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12414-5","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,10]]},"assertion":[{"value":"14 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflicts of interest.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The collection of human umbilical cord and isolation of mesenchymal stem cells was conducted in accordance with the Declaration of Helsinki, and approved by the Ethics Committee of Guizhou Medical University on 2 March 2021 (approval number 2021-28). The animal study protocol was approved by the Ethics Committee of Guizhou Medical University on 2 March 2021 (approval number 2100900).","order":2,"name":"Ethics","label":"Institutional Review Board Statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Informed Consent <b>Statement<\/b>:","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1376"}}