{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T07:03:32Z","timestamp":1784358212503,"version":"3.55.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"traditional Chinese medicine of Heilongjiang Chinese Medicine Administration","award":["ZHY2024-094"],"award-info":[{"award-number":["ZHY2024-094"]}]},{"name":"Innovation Team Project of Heilongjiang Provincial Department of Education","award":["2024-KYYWF-0612"],"award-info":[{"award-number":["2024-KYYWF-0612"]}]},{"DOI":"10.13039\/501100014902","name":"Jiamusi University","doi-asserted-by":"publisher","award":["DJXSTD202409"],"award-info":[{"award-number":["DJXSTD202409"]}],"id":[{"id":"10.13039\/501100014902","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Heilongjiang Provincial Natural Science Foundation of China","doi-asserted-by":"crossref","award":["LH2024H005"],"award-info":[{"award-number":["LH2024H005"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12417-2","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:33:04Z","timestamp":1784356384000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["APEX1 attenuates myocardial ischemia-reperfusion injury by inhibiting ferroptosis via the Nrf2\/GPX4 signaling pathway"],"prefix":"10.1007","volume":"53","author":[{"given":"Liuxin","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shulin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6041-9098","authenticated-orcid":false,"given":"Mingyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"issue":"17","key":"12417_CR1","doi-asserted-by":"publisher","first-page":"3773","DOI":"10.1113\/jp270953","volume":"593","author":"F Altamirano","year":"2015","unstructured":"Altamirano F, Wang ZV, Hill JA (2015) Cardioprotection in ischaemia-reperfusion injury: novel mechanisms and clinical translation. J Physiol 593(17):3773\u20133788. https:\/\/doi.org\/10.1113\/jp270953","journal-title":"J Physiol"},{"issue":"5","key":"12417_CR2","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1056\/NEJMoa071142","volume":"359","author":"C Piot","year":"2008","unstructured":"Piot C, Croisille P, Staat P, Thibault H, Rioufol G, Mewton N et al (2008) Effect of cyclosporine on reperfusion injury in acute myocardial infarction. N Engl J Med 359(5):473\u2013481. https:\/\/doi.org\/10.1056\/NEJMoa071142","journal-title":"N Engl J Med"},{"issue":"4","key":"12417_CR3","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.jacc.2015.10.081","volume":"67","author":"F Ottani","year":"2016","unstructured":"Ottani F, Latini R, Staszewsky L, La Vecchia L, Locuratolo N, Sicuro M et al (2016) Cyclosporine A in reperfused myocardial infarction: The multicenter, controlled, open-label CYCLE Trial. J Am Coll Cardiol 67(4):365\u2013374. https:\/\/doi.org\/10.1016\/j.jacc.2015.10.081","journal-title":"J Am Coll Cardiol"},{"issue":"20","key":"12417_CR4","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.1016\/j.jacc.2009.08.091","volume":"55","author":"H Thiele","year":"2010","unstructured":"Thiele H, Hildebrand L, Schirdewahn C, Eitel I, Adams V, Fuernau G et al (2010) Impact of high-dose N-acetylcysteine versus placebo on contrast-induced nephropathy and myocardial reperfusion injury in unselected patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. The LIPSIA-N-ACC (Prospective, Single-Blind, Placebo-Controlled, Randomized Leipzig Immediate PercutaneouS Coronary Intervention Acute Myocardial Infarction N-ACC) Trial. J Am Coll Cardiol 55(20):2201\u20132209. https:\/\/doi.org\/10.1016\/j.jacc.2009.08.091","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"12417_CR5","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s00395-021-00896-2","volume":"116","author":"R Francis","year":"2021","unstructured":"Francis R, Chong J, Ramlall M, Bucciarelli-Ducci C, Clayton T, Dodd M et al (2021) Effect of remote ischaemic conditioning on infarct size and remodelling in ST-segment elevation myocardial infarction patients: the CONDI-2\/ERIC-PPCI CMR substudy. Basic Res Cardiol 116(1):59. https:\/\/doi.org\/10.1007\/s00395-021-00896-2","journal-title":"Basic Res Cardiol"},{"issue":"5","key":"12417_CR6","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149(5):1060\u20131072. https:\/\/doi.org\/10.1016\/j.cell.2012.03.042","journal-title":"Cell"},{"issue":"3","key":"12417_CR7","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.tem.2023.10.010","volume":"35","author":"Q Xiang","year":"2024","unstructured":"Xiang Q, Yi X, Zhu XH, Wei X, Jiang DS (2024) Regulated cell death in myocardial ischemia-reperfusion injury. Trends Endocrinol Metab 35(3):219\u2013234. https:\/\/doi.org\/10.1016\/j.tem.2023.10.010","journal-title":"Trends Endocrinol Metab"},{"issue":"19","key":"12417_CR8","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1161\/circulationaha.122.060257","volume":"147","author":"W Cai","year":"2023","unstructured":"Cai W, Liu L, Shi X, Liu Y, Wang J, Fang X et al (2023) Alox15\/15-HpETE aggravates myocardial ischemia-reperfusion injury by promoting cardiomyocyte ferroptosis. Circulation 147(19):1444\u20131460. https:\/\/doi.org\/10.1161\/circulationaha.122.060257","journal-title":"Circulation"},{"issue":"1","key":"12417_CR9","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/s41392-025-02216-9","volume":"10","author":"X Wang","year":"2025","unstructured":"Wang X, Chen T, Chen S, Zhang J, Cai L, Liu C et al (2025) STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation. Signal Transduct Target therapy 10(1):136. https:\/\/doi.org\/10.1038\/s41392-025-02216-9","journal-title":"Signal Transduct Target therapy"},{"key":"12417_CR10","doi-asserted-by":"publisher","unstructured":"Liu L, Pang J, Qin D, Li R, Zou D, Chi K et al (2023) Deubiquitinase OTUD5 as a novel protector against 4-HNE-triggered ferroptosis in myocardial ischemia\/reperfusion injury. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10(28):e2301852. https:\/\/doi.org\/10.1002\/advs.202301852","DOI":"10.1002\/advs.202301852"},{"issue":"2","key":"12417_CR11","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1002\/j.1460-2075.1992.tb05097.x","volume":"11","author":"S Xanthoudakis","year":"1992","unstructured":"Xanthoudakis S, Curran T (1992) Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity. EMBO J 11(2):653\u2013665. https:\/\/doi.org\/10.1002\/j.1460-2075.1992.tb05097.x","journal-title":"EMBO J"},{"key":"12417_CR12","doi-asserted-by":"publisher","unstructured":"Lee YR, Joo HK, Lee EO, Park MS, Cho HS, Kim S et al (2020) Plasma APE1\/Ref-1 Correlates with Atherosclerotic Inflammation in ApoE(-\/-) Mice. Biomedicines 8(9). https:\/\/doi.org\/10.3390\/biomedicines8090366","DOI":"10.3390\/biomedicines8090366"},{"issue":"8","key":"12417_CR13","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.5966\/sctm.2015-0281","volume":"5","author":"T Aonuma","year":"2016","unstructured":"Aonuma T, Takehara N, Maruyama K, Kabara M, Matsuki M, Yamauchi A et al (2016) Apoptosis-resistant cardiac progenitor cells modified with Apurinic\/Apyrimidinic Endonuclease\/Redox Factor 1 gene overexpression regulate cardiac repair after myocardial infarction. Stem cells translational Med 5(8):1067\u20131078. https:\/\/doi.org\/10.5966\/sctm.2015-0281","journal-title":"Stem cells translational Med"},{"issue":"2","key":"12417_CR14","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1002\/ehf2.14686","volume":"11","author":"SY An","year":"2024","unstructured":"An SY, Jin SA, Seo HJ, Lee YR, Kim S, Jeon BH et al (2024) Protective effect of secretory APE1\/Ref-1 on doxorubicin-induced cardiotoxicity via suppression of ROS and p53 pathway. ESC heart Fail 11(2):1182\u20131193. https:\/\/doi.org\/10.1002\/ehf2.14686","journal-title":"ESC heart Fail"},{"issue":"5","key":"12417_CR15","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1161\/01.res.88.5.529","volume":"88","author":"T Ide","year":"2001","unstructured":"Ide T, Tsutsui H, Hayashidani S, Kang D, Suematsu N, Nakamura K et al (2001) Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction. Circul Res 88(5):529\u2013535. https:\/\/doi.org\/10.1161\/01.res.88.5.529","journal-title":"Circul Res"},{"issue":"6","key":"12417_CR16","doi-asserted-by":"publisher","first-page":"586","DOI":"10.4162\/nrp.2015.9.6.586","volume":"9","author":"KP Lee","year":"2015","unstructured":"Lee KP, Kim JE, Park WH (2015) Cytoprotective effect of rhamnetin on miconazole-induced H9c2 cell damage. Nutr Res Pract 9(6):586\u2013591. https:\/\/doi.org\/10.4162\/nrp.2015.9.6.586","journal-title":"Nutr Res Pract"},{"key":"12417_CR17","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.mito.2014.05.006","volume":"17","author":"HK Joo","year":"2014","unstructured":"Joo HK, Lee YR, Park MS, Choi S, Park K, Lee SK et al (2014) Mitochondrial APE1\/Ref-1 suppressed protein kinase C-induced mitochondrial dysfunction in mouse endothelial cells. Mitochondrion 17:42\u201349. https:\/\/doi.org\/10.1016\/j.mito.2014.05.006","journal-title":"Mitochondrion"},{"issue":"4","key":"12417_CR18","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/s41418-024-01270-0","volume":"31","author":"Y Du","year":"2024","unstructured":"Du Y, Zhou Y, Yan X, Pan F, He L, Guo Z et al (2024) APE1 inhibition enhances ferroptotic cell death and contributes to hepatocellular carcinoma therapy. Cell Death Differ 31(4):431\u2013446. https:\/\/doi.org\/10.1038\/s41418-024-01270-0","journal-title":"Cell Death Differ"},{"issue":"1\u20132","key":"12417_CR19","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s10495-022-01785-2","volume":"28","author":"X Han","year":"2023","unstructured":"Han X, Zhang J, Liu J, Wang H, Du F, Zeng X et al (2023) Targeting ferroptosis: a novel insight against myocardial infarction and ischemia-reperfusion injuries. Apoptosis: Int J Program cell death 28(1\u20132):108\u2013123. https:\/\/doi.org\/10.1007\/s10495-022-01785-2","journal-title":"Apoptosis: Int J Program cell death"},{"key":"12417_CR20","doi-asserted-by":"publisher","first-page":"111529","DOI":"10.1016\/j.intimp.2024.111529","volume":"128","author":"J Diao","year":"2024","unstructured":"Diao J, Fan H, Zhang J, Fu X, Liao R, Zhao P et al (2024) Activation of APE1 modulates Nrf2 protected against acute liver injury by inhibit hepatocyte ferroptosis and promote hepatocyte autophagy. Int Immunopharmacol 128:111529. https:\/\/doi.org\/10.1016\/j.intimp.2024.111529","journal-title":"Int Immunopharmacol"},{"key":"12417_CR21","doi-asserted-by":"publisher","first-page":"798304","DOI":"10.3389\/fonc.2022.798304","volume":"12","author":"N Guo","year":"2022","unstructured":"Guo N, Chen Y, Zhang Y, Deng Y, Zeng F, Li X (2022) Potential role of APEX1 during ferroptosis. Front Oncol 12:798304. https:\/\/doi.org\/10.3389\/fonc.2022.798304","journal-title":"Front Oncol"},{"issue":"7","key":"12417_CR22","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.7150\/ijms.50804","volume":"18","author":"YT Bai","year":"2021","unstructured":"Bai YT, Xiao FJ, Wang H, Ge RL, Wang LS (2021) Hypoxia protects H9c2 cells against Ferroptosis through SENP1-mediated protein DeSUMOylation. Int J Med Sci 18(7):1618\u20131627. https:\/\/doi.org\/10.7150\/ijms.50804","journal-title":"Int J Med Sci"},{"issue":"5","key":"12417_CR23","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1038\/s41401-022-01018-x","volume":"44","author":"YJ Lan","year":"2023","unstructured":"Lan YJ, Cheng MH, Ji HM, Bi YQ, Han YY, Yang CY et al (2023) Melatonin ameliorates bleomycin-induced pulmonary fibrosis via activating NRF2 and inhibiting galectin-3 expression. Acta Pharmacol Sin 44(5):1029\u20131037. https:\/\/doi.org\/10.1038\/s41401-022-01018-x","journal-title":"Acta Pharmacol Sin"},{"key":"12417_CR24","doi-asserted-by":"publisher","unstructured":"Yan T, Li X, Wang X, He B, Jia Y, Xiao W (2024) Salidroside alleviates myocardial ischemia reperfusion by balancing mitochondrial homeostasis via Nrf2. 2024(1):9971510. https:\/\/doi.org\/10.1155\/2024\/9971510","DOI":"10.1155\/2024\/9971510"},{"issue":"18","key":"12417_CR25","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1161\/01.Cir.0000065598.46411.Ef","volume":"107","author":"S Fleury","year":"2003","unstructured":"Fleury S, Simeoni E, Zuppinger C, D\u00e9glon N, von Segesser LK, Kappenberger L et al (2003) Multiply attenuated, self-inactivating lentiviral vectors efficiently deliver and express genes for extended periods of time in adult rat cardiomyocytes in vivo. Circulation 107(18):2375\u20132382. https:\/\/doi.org\/10.1161\/01.Cir.0000065598.46411.Ef","journal-title":"Circulation"},{"issue":"3","key":"12417_CR26","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.mvr.2009.06.011","volume":"78","author":"YG Li","year":"2009","unstructured":"Li YG, Zhang PP, Jiao KL, Zou YZ (2009) Knockdown of microRNA-181 by lentivirus mediated siRNA expression vector decreases the arrhythmogenic effect of skeletal myoblast transplantation in rat with myocardial infarction. Microvasc Res 78(3):393\u2013404. https:\/\/doi.org\/10.1016\/j.mvr.2009.06.011","journal-title":"Microvasc Res"},{"issue":"17","key":"12417_CR27","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1161\/circulationaha.125.075254","volume":"152","author":"M Greco","year":"2025","unstructured":"Greco M, Lombardi G, Brusasco C, Pieri M, Roasio A, Monaco F et al (2025) Effect of remote ischemic preconditioning on myocardial injury in noncardiac surgery: The PRINCE randomized clinical trial. Circulation 152(17):1194\u20131205. https:\/\/doi.org\/10.1161\/circulationaha.125.075254","journal-title":"Circulation"},{"issue":"7","key":"12417_CR28","doi-asserted-by":"publisher","first-page":"Cd014920","DOI":"10.1002\/14651858.CD014920.pub2","volume":"7","author":"FE Botelho","year":"2024","unstructured":"Botelho FE, Flumignan RL, Shiomatsu GY, de Castro-Santos G, Cacione DG, Leite JO et al (2024) Preoperative coronary interventions for preventing acute myocardial infarction in the perioperative period of major open vascular or endovascular surgery. Cochrane Database Syst Rev 7(7):Cd014920. https:\/\/doi.org\/10.1002\/14651858.CD014920.pub2","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"12417_CR29","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.ccell.2024.03.011","volume":"42","author":"G Lei","year":"2024","unstructured":"Lei G, Zhuang L, Gan B (2024) The roles of ferroptosis in cancer: Tumor suppression, tumor microenvironment, and therapeutic interventions. Cancer Cell 42(4):513\u2013534. https:\/\/doi.org\/10.1016\/j.ccell.2024.03.011","journal-title":"Cancer Cell"},{"issue":"3","key":"12417_CR30","doi-asserted-by":"publisher","first-page":"e2409176","DOI":"10.1002\/adma.202409176","volume":"37","author":"R Wang","year":"2025","unstructured":"Wang R, Nie W, Yan X, Luo K, Zhang Q, Wang T et al (2025) Biomimetic nanomotors for deep ischemia penetration and ferroptosis inhibition in neuroprotective therapy of ischemic stroke. Advanced materials (Deerfield Beach. Fla) 37(3):e2409176. https:\/\/doi.org\/10.1002\/adma.202409176","journal-title":"Fla)"},{"issue":"1","key":"12417_CR31","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s12951-025-03197-1","volume":"23","author":"K Zhu","year":"2025","unstructured":"Zhu K, Wang K, Zhang R, Zhu Z, Wang W, Yang B et al (2025) Iron chelators loaded on myocardiocyte mitochondria-targeted nanozyme system for treating myocardial ischemia-reperfusion injury in mouse models. J Nanobiotechnol 23(1):112. https:\/\/doi.org\/10.1186\/s12951-025-03197-1","journal-title":"J Nanobiotechnol"},{"issue":"9","key":"12417_CR32","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1016\/j.bmc.2017.01.028","volume":"25","author":"SS Laev","year":"2017","unstructured":"Laev SS, Salakhutdinov NF, Lavrik OI (2017) Inhibitors of nuclease and redox activity of apurinic\/apyrimidinic endonuclease 1\/redox effector factor 1 (APE1\/Ref-1). Bioorg Med Chem 25(9):2531\u20132544. https:\/\/doi.org\/10.1016\/j.bmc.2017.01.028","journal-title":"Bioorg Med Chem"},{"issue":"2","key":"12417_CR33","doi-asserted-by":"publisher","first-page":"e22640","DOI":"10.1002\/jbt.22640","volume":"35","author":"S Thakur","year":"2021","unstructured":"Thakur S, Sarkar B, Dhiman M, Mantha AK (2021) Organophosphate-pesticides induced survival mechanisms and APE1-mediated Nrf2 regulation in non-small-cell lung cancer cells. J Biochem Mol Toxicol 35(2):e22640. https:\/\/doi.org\/10.1002\/jbt.22640","journal-title":"J Biochem Mol Toxicol"},{"issue":"5","key":"12417_CR34","doi-asserted-by":"publisher","first-page":"3057","DOI":"10.1074\/jbc.M114.621995","volume":"290","author":"ML Fishel","year":"2015","unstructured":"Fishel ML, Wu X, Devlin CM, Logsdon DP, Jiang Y, Luo M et al (2015) Apurinic\/apyrimidinic endonuclease\/redox factor-1 (APE1\/Ref-1) redox function negatively regulates NRF2. J Biol Chem 290(5):3057\u20133068. https:\/\/doi.org\/10.1074\/jbc.M114.621995","journal-title":"J Biol Chem"},{"key":"12417_CR35","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.actbio.2023.02.025","volume":"160","author":"W Qian","year":"2023","unstructured":"Qian W, Liu D, Han Y, Liu M, Liu B, Ji Q et al (2023) Cyclosporine A-loaded apoferritin alleviates myocardial ischemia-reperfusion injury by simultaneously blocking ferroptosis and apoptosis of cardiomyocytes. Acta Biomater 160:265\u2013280. https:\/\/doi.org\/10.1016\/j.actbio.2023.02.025","journal-title":"Acta Biomater"},{"key":"12417_CR36","doi-asserted-by":"publisher","first-page":"9929687","DOI":"10.1155\/2021\/9929687","volume":"2021","author":"WK Zhao","year":"2021","unstructured":"Zhao WK, Zhou Y, Xu TT, Wu Q, Ferroptosis (2021) Opportunities and challenges in myocardial ischemia-reperfusion injury. Oxidative Med Cell Longev 2021:9929687. https:\/\/doi.org\/10.1155\/2021\/9929687","journal-title":"Oxidative Med Cell Longev"},{"issue":"7","key":"12417_CR37","doi-asserted-by":"publisher","first-page":"3329","DOI":"10.1007\/s10571-023-01388-8","volume":"43","author":"X Gao","year":"2023","unstructured":"Gao X, Hu W, Qian D, Bai X, He H, Li L et al (2023) The mechanisms of ferroptosis under hypoxia. Cell Mol Neurobiol 43(7):3329\u20133341. https:\/\/doi.org\/10.1007\/s10571-023-01388-8","journal-title":"Cell Mol Neurobiol"},{"issue":"10","key":"12417_CR38","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1016\/j.freeradbiomed.2004.02.075","volume":"36","author":"K Itoh","year":"2004","unstructured":"Itoh K, Tong KI, Yamamoto M (2004) Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. Free Radic Biol Med 36(10):1208\u20131213. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2004.02.075","journal-title":"Free Radic Biol Med"},{"key":"12417_CR39","doi-asserted-by":"publisher","first-page":"101107","DOI":"10.1016\/j.redox.2019.101107","volume":"23","author":"M Dodson","year":"2019","unstructured":"Dodson M, Castro-Portuguez R, Zhang DD (2019) NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis. Redox Biol 23:101107. https:\/\/doi.org\/10.1016\/j.redox.2019.101107","journal-title":"Redox Biol"},{"key":"12417_CR40","doi-asserted-by":"publisher","first-page":"103417","DOI":"10.1016\/j.redox.2024.103417","volume":"78","author":"Q Zheng","year":"2024","unstructured":"Zheng Q, Xing J, Li X, Tang X, Zhang D (2024) PRDM16 suppresses ferroptosis to protect against sepsis-associated acute kidney injury by targeting the NRF2\/GPX4 axis. Redox Biol 78:103417. https:\/\/doi.org\/10.1016\/j.redox.2024.103417","journal-title":"Redox Biol"},{"issue":"1","key":"12417_CR41","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1186\/s12951-022-01654-9","volume":"20","author":"H Sun","year":"2022","unstructured":"Sun H, Cai H, Xu C, Zhai H, Lux F, Xie Y et al (2022) AGuIX nanoparticles enhance ionizing radiation-induced ferroptosis on tumor cells by targeting the NRF2-GPX4 signaling pathway. J Nanobiotechnol 20(1):449. https:\/\/doi.org\/10.1186\/s12951-022-01654-9","journal-title":"J Nanobiotechnol"},{"issue":"1","key":"12417_CR42","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/s41420-022-01173-4","volume":"8","author":"T Zhao","year":"2022","unstructured":"Zhao T, Yu Z, Zhou L, Wang X, Hui Y, Mao L et al (2022) Regulating Nrf2-GPx4 axis by bicyclol can prevent ferroptosis in carbon tetrachloride-induced acute liver injury in mice. Cell death discovery 8(1):380. https:\/\/doi.org\/10.1038\/s41420-022-01173-4","journal-title":"Cell death discovery"},{"key":"12417_CR43","doi-asserted-by":"publisher","first-page":"116479","DOI":"10.1016\/j.bcp.2024.116479","volume":"229","author":"M Tan","year":"2024","unstructured":"Tan M, Yin Y, Chen W, Zhang J, Jin Y, Zhang Y et al (2024) Trimetazidine attenuates Ischemia\/Reperfusion-Induced myocardial ferroptosis by modulating the Sirt3\/Nrf2-GSH system and reducing Oxidative\/Nitrative stress. Biochem Pharmacol 229:116479. https:\/\/doi.org\/10.1016\/j.bcp.2024.116479","journal-title":"Biochem Pharmacol"},{"key":"12417_CR44","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.freeradbiomed.2024.10.260","volume":"225","author":"Q Chen","year":"2024","unstructured":"Chen Q, Chen T, Xiao H, Wang F, Li C, Hu N et al (2024) APEX1 in intestinal epithelium triggers neutrophil infiltration and intestinal barrier damage in ulcerative colitis. Free Radic Biol Med 225:359\u2013373. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2024.10.260","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"12417_CR45","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s12920-022-01290-0","volume":"15","author":"L Peng","year":"2022","unstructured":"Peng L, Liu Y, Chen J, Cheng M, Wu Y, Chen M et al (2022) APEX1 regulates alternative splicing of key tumorigenesis genes in non-small-cell lung cancer. BMC Med Genom 15(1):147. https:\/\/doi.org\/10.1186\/s12920-022-01290-0","journal-title":"BMC Med Genom"},{"issue":"5","key":"12417_CR46","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3892\/mco.2024.2780","volume":"21","author":"L Yang","year":"2024","unstructured":"Yang L, Sun Z (2024) Role of APE1 in hepatocellular carcinoma and its prospects as a target in clinical settings (Review). Mol Clin Oncol 21(5):82. https:\/\/doi.org\/10.3892\/mco.2024.2780","journal-title":"Mol Clin Oncol"},{"key":"12417_CR47","doi-asserted-by":"publisher","first-page":"34432","DOI":"10.1038\/srep34432","volume":"6","author":"IK Song","year":"2016","unstructured":"Song IK, Lee JJ, Cho JH, Jeong J, Shin DH, Lee KJ (2016) Degradation of Redox-Sensitive Proteins including Peroxiredoxins and DJ-1 is Promoted by Oxidation-induced Conformational Changes and Ubiquitination. Sci Rep 6:34432. https:\/\/doi.org\/10.1038\/srep34432","journal-title":"Sci Rep"},{"issue":"9","key":"12417_CR48","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.tibs.2024.07.001","volume":"49","author":"A Ulfig","year":"2024","unstructured":"Ulfig A, Jakob U (2024) Cellular oxidants and the proteostasis network: balance between activation and destruction. Trends Biochem Sci 49(9):761\u2013774. https:\/\/doi.org\/10.1016\/j.tibs.2024.07.001","journal-title":"Trends Biochem Sci"},{"key":"12417_CR49","doi-asserted-by":"publisher","unstructured":"Tummanatsakun D, Proungvitaya T, Roytrakul S, Limpaiboon T, Wongkham S, Wongkham C et al (2019) Serum Apurinic\/Apyrimidinic endodeoxyribonuclease 1 (APEX1) level as a potential biomarker of Cholangiocarcinoma. Biomolecules 9(9). https:\/\/doi.org\/10.3390\/biom9090413","DOI":"10.3390\/biom9090413"},{"key":"12417_CR50","doi-asserted-by":"publisher","unstructured":"Chen Y, Li X, Wang S, Miao R, Zhong J (2023) Targeting iron metabolism and ferroptosis as novel therapeutic approaches in cardiovascular diseases. Nutrients 15(3). https:\/\/doi.org\/10.3390\/nu15030591","DOI":"10.3390\/nu15030591"},{"key":"12417_CR51","doi-asserted-by":"publisher","first-page":"175394472412773","DOI":"10.1177\/17539447241277382","volume":"18","author":"A Lamichhane","year":"2024","unstructured":"Lamichhane A, Sharma S, Bastola B, Chhusyabaga B, Shrestha N, Poudel P (2024) Unlocking the potential of deferoxamine: a systematic review on its efficacy and safety in alleviating myocardial ischemia-reperfusion injury in adult patients following cardiopulmonary bypass compared to standard care. Ther Adv Cardiovasc Dis 18:17539447241277382. https:\/\/doi.org\/10.1177\/17539447241277382","journal-title":"Ther Adv Cardiovasc Dis"},{"issue":"1","key":"12417_CR52","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s40164-023-00411-4","volume":"12","author":"X Liu","year":"2023","unstructured":"Liu X, Zhong S, Qiu K, Chen X, Wu W, Zheng J et al (2023) Targeting NRF2 uncovered an intrinsic susceptibility of acute myeloid leukemia cells to ferroptosis. Experimental Hematol Oncol 12(1):47. https:\/\/doi.org\/10.1186\/s40164-023-00411-4","journal-title":"Experimental Hematol Oncol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12417-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12417-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12417-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:33:06Z","timestamp":1784356386000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12417-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,18]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12417"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12417-2","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,18]]},"assertion":[{"value":"15 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Jiamusi University (Ethics Approval No.: JDJCYXY20250014, Date: March 10, 2025).","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1203"}}