{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:47:24Z","timestamp":1791830844564,"version":"4.3.4"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Royal Jelly (RJ) is widely used in cosmetics for its beneficial skin effects, but its impact on cellular senescence remains unclear. Senomorphic agents that suppress the senescence-associated secretory phenotype (SASP) offer safe therapeutic strategies for skin aging. This study investigates the senomorphic effects of RJ on epidermal senescence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      We utilized an\n                      <jats:italic>in vitro<\/jats:italic>\n                      replicative senescence model of normal human epidermal keratinocytes, validating our findings with cells from chronologically aged adult donors, including a 75-year-old. Results demonstrated that RJ significantly suppresses multiple SASP factors, including interleukin (IL)-6 and C-X-C motif ligand (CXCL) family members, in both models without inducing cytotoxicity. Mechanistically, RNA-sequencing revealed that senescence upregulated pro-inflammatory factors via TNF-\u03b1 and NF-\u03baB signaling pathways. RJ acts as a multitarget senomorphic agent, inhibiting these senescence-activated pathways and reducing oxidative stress.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RJ is a potent natural senomorphic agent capable of modulating complex SASP networks. It provides valuable insights into potential strategies for mitigating skin inflammation and preserving youthfulness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11033-026-12431-4","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T08:33:46Z","timestamp":1785141226000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Royal jelly suppresses senescence-associated secretory phenotype in senescent human epidermal keratinocytes"],"prefix":"10.1007","volume":"53","author":[{"given":"Yukie","family":"Nakagawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2904-4640","authenticated-orcid":false,"given":"Hideto","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2997-7291","authenticated-orcid":false,"given":"Nobuaki","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"12431_CR1","doi-asserted-by":"publisher","first-page":"3291","DOI":"10.3390\/molecules25143291","volume":"25","author":"A B\u0103lan","year":"2020","unstructured":"B\u0103lan A, Moga MA, Dima L, Toma S, Elena Neculau A, Anastasiu CV (2020) Royal jelly-a traditional and natural remedy for postmenopausal symptoms and aging-related pathologies. Molecules 25:3291. https:\/\/doi.org\/10.3390\/molecules25143291","journal-title":"Molecules"},{"key":"12431_CR2","first-page":"79","volume":"48","author":"T Asama","year":"2020","unstructured":"Asama T, Okumura N, Yamaki A, Okuma A, Numano K (2020) Effect of protease-digested royal jelly supplementation on skin conditions and safety in healthy Japanese adults\u2014a randomized, double-blind, placebo-controlled, parallel-group comparison study. Jpn Pharmacol Ther 48:79\u201388","journal-title":"Jpn Pharmacol Ther"},{"key":"12431_CR3","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15168","author":"Y Maeda","year":"2022","unstructured":"Maeda Y, Fujikura C, Asama T, Yagi M, Okumura N, Yamaki A et al (2022) Effect of facial application of essence containing royal jelly extract on stratum corneum moisture content: a placebo-controlled, double-blind, parallel-group study. J Cosmet Dermatol. https:\/\/doi.org\/10.1111\/jocd.15168","journal-title":"J Cosmet Dermatol"},{"key":"12431_CR4","doi-asserted-by":"publisher","first-page":"12973","DOI":"10.3390\/ijms222312973","volume":"22","author":"N Okumura","year":"2021","unstructured":"Okumura N, Ito T, Degawa T, Moriyama M, Moriyama H (2021) Royal jelly protects against epidermal stress through upregulation of the NQO1 expression. Int J Mol Sci 22:12973. https:\/\/doi.org\/10.3390\/ijms222312973","journal-title":"Int J Mol Sci"},{"key":"12431_CR5","doi-asserted-by":"publisher","first-page":"7834381","DOI":"10.1155\/2018\/7834381","volume":"2018","author":"MM You","year":"2018","unstructured":"You MM, Chen YF, Pan YM, Liu YC, Tu J, Wang K et al (2018) Royal jelly attenuates LPS-induced inflammation in BV-2 microglial cells through modulating NF-\u03baB and p38\/JNK signaling pathways. Mediators Inflamm 2018:7834381. https:\/\/doi.org\/10.1155\/2018\/7834381","journal-title":"Mediators Inflamm"},{"key":"12431_CR6","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1271\/bbb.68.138","volume":"68","author":"K Kohno","year":"2004","unstructured":"Kohno K, Okamoto I, Sano O, Arai N, Iwaki K, Ikeda M et al (2004) Royal jelly inhibits the production of proinflammatory cytokines by activated macrophages. Biosci Biotechnol Biochem 68:138\u2013145. https:\/\/doi.org\/10.1271\/bbb.68.138","journal-title":"Biosci Biotechnol Biochem"},{"key":"12431_CR7","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/iwj.12063","volume":"12","author":"M Siavash","year":"2015","unstructured":"Siavash M, Shokri S, Haghighi S, Shahtalebi MA, Farajzadehgan Z (2015) The efficacy of topical royal jelly on healing of diabetic foot ulcers: a double-blind placebo-controlled clinical trial. Int Wound J 12:137\u2013142. https:\/\/doi.org\/10.1111\/iwj.12063","journal-title":"Int Wound J"},{"key":"12431_CR8","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1248\/bpb.b24-00607","volume":"47","author":"M Moriyama","year":"2024","unstructured":"Moriyama M, Miyake Y, Okumura N, Moriyama H (2024) Royal jelly maintains epidermal stem cell properties by repressing senescence. Biol Pharm Bull 47:2041\u20132049. https:\/\/doi.org\/10.1248\/bpb.b24-00607","journal-title":"Biol Pharm Bull"},{"key":"12431_CR9","doi-asserted-by":"publisher","first-page":"e37138","DOI":"10.1016\/j.heliyon.2024.e37138","volume":"10","author":"R Kumar","year":"2024","unstructured":"Kumar R, Thakur A, Kumar S, Hajam YA (2024) Royal jelly a promising therapeutic intervention and functional food supplement: a systematic review. Heliyon 10:e37138. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e37138","journal-title":"Heliyon"},{"key":"12431_CR10","doi-asserted-by":"publisher","first-page":"6023","DOI":"10.3390\/ijms25116023","volume":"25","author":"N Or\u0161oli\u0107","year":"2024","unstructured":"Or\u0161oli\u0107 N, Jazvin\u0161\u0107akJembrek M (2024) Royal jelly: biological action and health benefits. Int J Mol Sci 25:6023. https:\/\/doi.org\/10.3390\/ijms25116023","journal-title":"Int J Mol Sci"},{"key":"12431_CR11","doi-asserted-by":"publisher","first-page":"111525","DOI":"10.1016\/j.mad.2021.111525","volume":"198","author":"CY Ho","year":"2021","unstructured":"Ho CY, Dreesen O (2021) Faces of cellular senescence in skin aging. Mech Ageing Dev 198:111525. https:\/\/doi.org\/10.1016\/j.mad.2021.111525","journal-title":"Mech Ageing Dev"},{"key":"12431_CR12","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1051\/medsci\/2020223","volume":"36","author":"J Rorteau","year":"2020","unstructured":"Rorteau J, Chevalier FP, Fromy B, Lamartine J (2020) Functional integrity of aging skin, from cutaneous biology to anti-aging strategies. Med Sci (Paris) 36:1155\u20131162. https:\/\/doi.org\/10.1051\/medsci\/2020223","journal-title":"Med Sci (Paris)"},{"key":"12431_CR13","doi-asserted-by":"publisher","first-page":"e158450","DOI":"10.1172\/jci158450","volume":"132","author":"L Zhang","year":"2022","unstructured":"Zhang L, Pitcher LE, Yousefzadeh MJ, Niedernhofer LJ, Robbins PD, Zhu Y (2022) Cellular senescence: a key therapeutic target in aging and diseases. J Clin Invest 132:e158450. https:\/\/doi.org\/10.1172\/jci158450","journal-title":"J Clin Invest"},{"key":"12431_CR14","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1159\/000534756","volume":"70","author":"SP Wyles","year":"2024","unstructured":"Wyles SP, Carruthers JD, Dashti P, Yu G, Yap JQ, Gingery A et al (2024) Cellular senescence in human skin aging: leveraging senotherapeutics. Gerontology 70:7\u201314. https:\/\/doi.org\/10.1159\/000534756","journal-title":"Gerontology"},{"key":"12431_CR15","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/0014-4827(61)90192-6","volume":"25","author":"L Hayflick","year":"1961","unstructured":"Hayflick L, Moorhead PS (1961) The serial cultivation of human diploid cell strains. Exp Cell Res 25:585\u2013621. https:\/\/doi.org\/10.1016\/0014-4827(61)90192-6","journal-title":"Exp Cell Res"},{"key":"12431_CR16","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1111\/exd.14818","volume":"32","author":"Y Ogata","year":"2023","unstructured":"Ogata Y, Yamada T, Hasegawa S, Sugiura K, Akamatsu H (2023) Changes of senescent cell accumulation and removal in skin tissue with ageing. Exp Dermatol 32:1159\u20131161. https:\/\/doi.org\/10.1111\/exd.14818","journal-title":"Exp Dermatol"},{"key":"12431_CR17","doi-asserted-by":"publisher","first-page":"12651","DOI":"10.18632\/aging.206117","volume":"16","author":"LW Xu","year":"2024","unstructured":"Xu LW, Sun YD, Fu QY, Wu D, Lin J, Wang C et al (2024) Unveiling senescence-associated secretory phenotype in epidermal aging: insights from reversibly immortalized keratinocytes. Aging (Albany NY) 16:12651\u201312666. https:\/\/doi.org\/10.18632\/aging.206117","journal-title":"Aging (Albany NY)"},{"key":"12431_CR18","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1038\/s41580-024-00727-x","volume":"25","author":"B Wang","year":"2024","unstructured":"Wang B, Han J, Elisseeff JH, Demaria M (2024) The senescence-associated secretory phenotype and its physiological and pathological implications. Nat Rev Mol Cell Biol 25:958\u2013978. https:\/\/doi.org\/10.1038\/s41580-024-00727-x","journal-title":"Nat Rev Mol Cell Biol"},{"key":"12431_CR19","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1038\/ncb2784","volume":"15","author":"JC Acosta","year":"2013","unstructured":"Acosta JC, Banito A, Wuestefeld T, Georgilis A, Janich P, Morton JP et al (2013) A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol 15:978\u2013990. https:\/\/doi.org\/10.1038\/ncb2784","journal-title":"Nat Cell Biol"},{"key":"12431_CR20","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1080\/15384101.2020.1728016","volume":"19","author":"S Victorelli","year":"2020","unstructured":"Victorelli S, Passos JF (2020) Telomeres: beacons of autocrine and paracrine DNA damage during skin aging. Cell Cycle 19:532\u2013540. https:\/\/doi.org\/10.1080\/15384101.2020.1728016","journal-title":"Cell Cycle"},{"key":"12431_CR21","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1038\/ncb1448","volume":"8","author":"RM Kortlever","year":"2006","unstructured":"Kortlever RM, Higgins PJ, Bernards R (2006) Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nat Cell Biol 8:877\u2013884. https:\/\/doi.org\/10.1038\/ncb1448","journal-title":"Nat Cell Biol"},{"key":"12431_CR22","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/j.cell.2008.03.038","volume":"133","author":"JC Acosta","year":"2008","unstructured":"Acosta JC, O\u2019Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S et al (2008) Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 133:1006\u20131018. https:\/\/doi.org\/10.1016\/j.cell.2008.03.038","journal-title":"Cell"},{"key":"12431_CR23","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1038\/jid.2015.108","volume":"135","author":"M Demaria","year":"2015","unstructured":"Demaria M, Desprez PY, Campisi J, Velarde MC (2015) Cell autonomous and non-autonomous effects of senescent cells in the skin. J Invest Dermatol 135:1722\u20131726. https:\/\/doi.org\/10.1038\/jid.2015.108","journal-title":"J Invest Dermatol"},{"key":"12431_CR24","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.cell.2017.05.015","volume":"169","author":"S He","year":"2017","unstructured":"He S, Sharpless NE (2017) Senescence in health and disease. Cell 169:1000\u20131011. https:\/\/doi.org\/10.1016\/j.cell.2017.05.015","journal-title":"Cell"},{"key":"12431_CR25","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.molmed.2021.12.003","volume":"28","author":"AC Franco","year":"2022","unstructured":"Franco AC, Aveleira C, Cavadas C (2022) Skin senescence: mechanisms and impact on whole-body aging. Trends Mol Med 28:97\u2013109. https:\/\/doi.org\/10.1016\/j.molmed.2021.12.003","journal-title":"Trends Mol Med"},{"key":"12431_CR26","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1111\/febs.16350","volume":"290","author":"L Zhang","year":"2023","unstructured":"Zhang L, Pitcher LE, Prahalad V, Niedernhofer LJ, Robbins PD (2023) Targeting cellular senescence with senotherapeutics: senolytics and senomorphics. FEBS J 290:1362\u20131383. https:\/\/doi.org\/10.1111\/febs.16350","journal-title":"FEBS J"},{"key":"12431_CR27","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/ncb2070","volume":"12","author":"JI Jun","year":"2010","unstructured":"Jun JI, Lau LF (2010) The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat Cell Biol 12:676\u2013685. https:\/\/doi.org\/10.1038\/ncb2070","journal-title":"Nat Cell Biol"},{"key":"12431_CR28","doi-asserted-by":"publisher","first-page":"6814","DOI":"10.3390\/ijms22136814","volume":"22","author":"A Domaszewska-Szostek","year":"2021","unstructured":"Domaszewska-Szostek A, Puzianowska-Ku\u017anicka M, Kury\u0142owicz A (2021) Flavonoids in skin senescence prevention and treatment. Int J Mol Sci 22:6814. https:\/\/doi.org\/10.3390\/ijms22136814","journal-title":"Int J Mol Sci"},{"key":"12431_CR29","doi-asserted-by":"publisher","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","volume":"92","author":"GP Dimri","year":"1995","unstructured":"Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C et al (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 92:9363\u20139367. https:\/\/doi.org\/10.1073\/pnas.92.20.9363","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12431_CR30","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA et al (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 102:15545\u201315550. https:\/\/doi.org\/10.1073\/pnas.0506580102","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12431_CR31","doi-asserted-by":"publisher","first-page":"D687","DOI":"10.1093\/nar\/gkab1028","volume":"50","author":"M Gillespie","year":"2022","unstructured":"Gillespie M, Jassal B, Stephan R, Milacic M, Rothfels K, Senff-Ribeiro A et al (2022) The reactome pathway knowledgebase. Nucleic Acids Res 50:D687\u2013D692. https:\/\/doi.org\/10.1093\/nar\/gkab1028","journal-title":"Nucleic Acids Res"},{"key":"12431_CR32","doi-asserted-by":"publisher","first-page":"e2400079","DOI":"10.1002\/adbi.202400079","volume":"8","author":"S Muthamil","year":"2024","unstructured":"Muthamil S, Kim HY, Jang HJ, Lyu JH, Shin UC, Go Y et al (2024) Biomarkers of cellular senescence and aging: current state-of-the-art, challenges and future perspectives. Adv Biol (Weinh) 8:e2400079. https:\/\/doi.org\/10.1002\/adbi.202400079","journal-title":"Adv Biol (Weinh)"},{"key":"12431_CR33","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1016\/j.jid.2020.11.006","volume":"141","author":"SM Pilkington","year":"2021","unstructured":"Pilkington SM, Bulfone-Paus S, Griffiths CEM, Watson REB (2021) Inflammaging and the skin. J Invest Dermatol 141:1087\u20131095. https:\/\/doi.org\/10.1016\/j.jid.2020.11.006","journal-title":"J Invest Dermatol"},{"key":"12431_CR34","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.devcel.2020.11.002","volume":"56","author":"Z Zou","year":"2021","unstructured":"Zou Z, Long X, Zhao Q, Zheng Y, Song M, Ma S et al (2021) A single-cell transcriptomic atlas of human skin aging. Dev Cell 56:383-397.e8. https:\/\/doi.org\/10.1016\/j.devcel.2020.11.002","journal-title":"Dev Cell"},{"key":"12431_CR35","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1177\/1753425911416022","volume":"18","author":"T Sugiyama","year":"2012","unstructured":"Sugiyama T, Takahashi K, Tokoro S, Gotou T, Neri P, Mori H (2012) Inhibitory effect of 10-hydroxy-trans-2-decenoic acid on LPS-induced IL-6 production via reducing I\u03baB-\u03b6 expression. Innate Immun 18:429\u2013437. https:\/\/doi.org\/10.1177\/1753425911416022","journal-title":"Innate Immun"},{"key":"12431_CR36","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1007\/s10753-012-9556-0","volume":"36","author":"T Sugiyama","year":"2013","unstructured":"Sugiyama T, Takahashi K, Kuzumaki A, Tokoro S, Neri P, Mori H (2013) Inhibitory mechanism of 10-hydroxy-trans-2-decenoic acid (royal jelly acid) against lipopolysaccharide- and interferon-\u03b2-induced nitric oxide production. Inflammation 36:372\u2013378. https:\/\/doi.org\/10.1007\/s10753-012-9556-0","journal-title":"Inflammation"},{"key":"12431_CR37","doi-asserted-by":"publisher","first-page":"106501","DOI":"10.1016\/j.intimp.2020.106501","volume":"84","author":"M You","year":"2020","unstructured":"You M, Miao Z, Sienkiewicz O, Jiang X, Zhao X, Hu F (2020) 10-hydroxydecanoic acid inhibits LPS-induced inflammation by targeting p53 in microglial cells. Int Immunopharmacol 84:106501. https:\/\/doi.org\/10.1016\/j.intimp.2020.106501","journal-title":"Int Immunopharmacol"},{"key":"12431_CR38","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.reth.2021.06.007","volume":"18","author":"M Kawagishi-Hotta","year":"2021","unstructured":"Kawagishi-Hotta M, Hasegawa S, Inoue Y, Hasebe Y, Arima M, Iwata Y et al (2021) Gremlin 2 suppresses differentiation of stem\/progenitor cells in the human skin. Regen Ther 18:191\u2013201. https:\/\/doi.org\/10.1016\/j.reth.2021.06.007","journal-title":"Regen Ther"},{"key":"12431_CR39","doi-asserted-by":"publisher","first-page":"e70053","DOI":"10.1111\/acel.70053","volume":"24","author":"Y Wang","year":"2025","unstructured":"Wang Y, Yang J, Luo Y, Zhao Z, Yuan Y, Li J et al (2025) Targeting IGF1-induced cellular senescence to rejuvenate hair follicle aging. Aging Cell 24:e70053. https:\/\/doi.org\/10.1111\/acel.70053","journal-title":"Aging Cell"},{"key":"12431_CR40","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1101\/gad.17276711","volume":"25","author":"Y Chien","year":"2011","unstructured":"Chien Y, Scuoppo C, Wang X, Fang X, Balgley B, Bolden JE et al (2011) Control of the senescence-associated secretory phenotype by NF-\u03baB promotes senescence and enhances chemosensitivity. Genes Dev 25:2125\u20132136. https:\/\/doi.org\/10.1101\/gad.17276711","journal-title":"Genes Dev"},{"key":"12431_CR41","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1038\/emboj.2011.69","volume":"30","author":"A Freund","year":"2011","unstructured":"Freund A, Patil CK, Campisi J (2011) P38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. EMBO J 30:1536\u20131548. https:\/\/doi.org\/10.1038\/emboj.2011.69","journal-title":"EMBO J"},{"key":"12431_CR42","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.cellsig.2011.12.006","volume":"24","author":"A Salminen","year":"2012","unstructured":"Salminen A, Kauppinen A, Kaarniranta K (2012) Emerging role of NF-\u03baB signaling in the induction of senescence-associated secretory phenotype (SASP). Cell Signal 24:835\u2013845. https:\/\/doi.org\/10.1016\/j.cellsig.2011.12.006","journal-title":"Cell Signal"},{"key":"12431_CR43","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s13167-023-00330-8","volume":"14","author":"BG Baptista","year":"2023","unstructured":"Baptista BG, Lima LS, Ribeiro M, Britto IK, Alvarenga L, Kemp JA et al (2023) Royal jelly: a predictive, preventive and personalised strategy for novel treatment options in non-communicable diseases. EPMA J 14:381\u2013404. https:\/\/doi.org\/10.1007\/s13167-023-00330-8","journal-title":"EPMA J"},{"key":"12431_CR44","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.cmet.2014.01.001","volume":"19","author":"J Li","year":"2014","unstructured":"Li J, Kim SG, Blenis J (2014) Rapamycin: one drug, many effects. Cell Metab 19:373\u2013379. https:\/\/doi.org\/10.1016\/j.cmet.2014.01.001","journal-title":"Cell Metab"},{"key":"12431_CR45","doi-asserted-by":"publisher","first-page":"8960","DOI":"10.3390\/ijms21238960","volume":"21","author":"JE Chang","year":"2020","unstructured":"Chang JE, Choi MS (2020) A molecular perspective on the potential benefits of metformin for the treatment of inflammatory skin disorders. Int J Mol Sci 21:8960. https:\/\/doi.org\/10.3390\/ijms21238960","journal-title":"Int J Mol Sci"},{"key":"12431_CR46","doi-asserted-by":"publisher","first-page":"1170434","DOI":"10.3389\/fragi.2023.1170434","volume":"4","author":"IY Abdelgawad","year":"2023","unstructured":"Abdelgawad IY, Agostinucci K, Sadaf B, Grant MKO, Zordoky BN (2023) Metformin mitigates SASP secretion and LPS-triggered hyper-inflammation in doxorubicin-induced senescent endothelial cells. Front Aging 4:1170434. https:\/\/doi.org\/10.3389\/fragi.2023.1170434","journal-title":"Front Aging"},{"key":"12431_CR47","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s41580-020-00314-w","volume":"22","author":"R Di Micco","year":"2021","unstructured":"Di Micco R, Krizhanovsky V, Baker D, d\u2019Adda di Fagagna F (2021) Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nat Rev Mol Cell Biol 22:75\u201395. https:\/\/doi.org\/10.1038\/s41580-020-00314-w","journal-title":"Nat Rev Mol Cell Biol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12431-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12431-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12431-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:22:12Z","timestamp":1785518532000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12431-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12431"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12431-4","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]},"assertion":[{"value":"27 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Y.N., H.O., and N.O. are employees of the Yamada Bee Company, Inc.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1270"}}