{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:21:02Z","timestamp":1789046462240,"version":"build-2803163510"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12433-2","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T08:39:28Z","timestamp":1784536768000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["4-Phenylbutyric acid attenuates endoplasmic reticulum stress-mediated polystyrene microplastic-induced nephrotoxicity in Wistar rats"],"prefix":"10.1007","volume":"53","author":[{"given":"Rachna","family":"Yadav","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Jangra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiten","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Nazish","family":"Quasmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sapana","family":"Kushwaha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Dhingra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"issue":"5672","key":"12433_CR1","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1126\/science.1094559","volume":"304","author":"RC Thompson","year":"2004","unstructured":"Thompson RC, Olsen Y, Mitchell RP, Davis A, Rowland SJ, John AW, Mcgonigle D, Russell AE (2004) Lost at sea: where is all the plastic? Science 304(5672):838\u2013838","journal-title":"Science"},{"key":"12433_CR2","doi-asserted-by":"publisher","first-page":"153784","DOI":"10.1016\/j.tox.2024.153784","volume":"504","author":"R Yadav","year":"2024","unstructured":"Yadav R, Kumar D, Singh J, Jangra A (2024) Environmental toxicants and nephrotoxicity: Implications on mechanisms and therapeutic strategies. Toxicology 504:153784. https:\/\/doi.org\/10.1016\/j.tox.2024.153784","journal-title":"Toxicology"},{"key":"12433_CR3","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/978-3-031-77327-3_11","volume":"Part F3811","author":"R Yadav","year":"2025","unstructured":"Yadav R, Jangra A, Rachamalla M, Kumar D (2025) Polystyrene: A Hazardous Risk to Marine as Well as Human Life. World Sustain Ser Part F3811:201\u2013223. https:\/\/doi.org\/10.1007\/978-3-031-77327-3_11","journal-title":"World Sustain Ser"},{"issue":"17","key":"12433_CR4","doi-asserted-by":"publisher","first-page":"9963","DOI":"10.3390\/su13179963","volume":"13","author":"R Kumar","year":"2021","unstructured":"Kumar R, Verma A, Shome A, Sinha R, Sinha S, Jha PK, Kumar R, Kumar P, Shubham, Das S, Sharma P, Prasad PVV (2021) Impacts of plastic pollution on ecosystem services, sustainable development goals, and need to focus on circular economy and policy interventions. Sustain (Switzerland) 13(17):9963. https:\/\/doi.org\/10.3390\/su13179963","journal-title":"Sustain (Switzerland)"},{"key":"12433_CR5","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.envpol.2015.09.018","volume":"207","author":"J Li","year":"2015","unstructured":"Li J, Yang D, Li L, Jabeen K, Shi H (2015) Microplastics in commercial bivalves from China. Environ Pollut 207:190\u2013195. https:\/\/doi.org\/10.1016\/j.envpol.2015.09.018","journal-title":"Environ Pollut"},{"key":"12433_CR6","doi-asserted-by":"publisher","first-page":"46687","DOI":"10.1038\/srep","volume":"7","author":"Y Deng","year":"2017","unstructured":"Deng Y, Zhang Y, Lemos B, Ren H (2017) Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure. Sci Rep 7:46687. https:\/\/doi.org\/10.1038\/srep","journal-title":"Sci Rep"},{"issue":"5","key":"12433_CR7","doi-asserted-by":"publisher","first-page":"057003","DOI":"10.1289\/EHP7612","volume":"129","author":"YL Wang","year":"2021","unstructured":"Wang YL, Lee YH, Hsu YH, Chiu IJ, Huang CCY, Huang CC, Chia ZC, Lee CP, Lin YF, Chiu HW (2021) The kidney-related effects of polystyrene microplastics on human kidney proximal tubular epithelial cells hk-2 and male c57bl\/6 mice. Environ Health Perspect 129(5):057003. https:\/\/doi.org\/10.1289\/EHP7612","journal-title":"Environ Health Perspect"},{"key":"12433_CR8","doi-asserted-by":"publisher","first-page":"128431","DOI":"10.1016\/j.jhazmat.2022.128431","volume":"430","author":"CW Lee","year":"2022","unstructured":"Lee CW, Hsu LF, Wu IL, Wang YL, Chen WC, Liu YJ, Yang LT, Tan CL, Luo YH, Wang CC, Chiu HW, Yang TCK, Lin YY, Chang HA, Chiang YC, Chen CH, Lee MH, Peng KT, Huang CCY (2022) Exposure to polystyrene microplastics impairs hippocampus-dependent learning and memory in mice. J Hazard Mater 430:128431. https:\/\/doi.org\/10.1016\/j.jhazmat.2022.128431","journal-title":"J Hazard Mater"},{"issue":"11","key":"12433_CR9","doi-asserted-by":"publisher","first-page":"103515","DOI":"10.1016\/j.jksus.2024.103515","volume":"36","author":"N Ghafoor","year":"2024","unstructured":"Ghafoor N, Fatima K, Batool M, Imran M, Hussain A, S., Atique U (2024) Ginkgetin alleviates polystyrene microplastics-instigated liver injury in rats through Nrf-2\/Keap-1 pathway activation. J King Saud Univ - Sci 36(11):103515. https:\/\/doi.org\/10.1016\/j.jksus.2024.103515","journal-title":"J King Saud Univ - Sci"},{"key":"12433_CR10","doi-asserted-by":"publisher","first-page":"152288","DOI":"10.1016\/j.scitotenv.2021.152288","volume":"811","author":"W Mao","year":"2022","unstructured":"Mao W, Mao L, Zhao N, Zhang Y, Zhao M, Jin H (2022) Disposition of Bisphenol S metabolites in Sprague-Dawley rats. Sci Total Environ 811:152288. https:\/\/doi.org\/10.1016\/j.scitotenv.2021.152288","journal-title":"Sci Total Environ"},{"issue":"1","key":"12433_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12986-016-0123-9","volume":"13","author":"SK Wong","year":"2016","unstructured":"Wong SK, Chin KY, Suhaimi FH, Fairus A, Ima-Nirwana S (2016) Animal models of metabolic syndrome: a review. Nutr Metabolism 13(1):1\u201312. https:\/\/doi.org\/10.1186\/s12986-016-0123-9","journal-title":"Nutr Metabolism"},{"key":"12433_CR12","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.chemosphere.2018.03.145","volume":"202","author":"K Lu","year":"2018","unstructured":"Lu K, Qiao R, An H, Zhang Y (2018) Influence of microplastics on the accumulation and chronic toxic effects of cadmium in zebrafish (Danio rerio). Chemosphere 202:514\u2013520. https:\/\/doi.org\/10.1016\/j.chemosphere.2018.03.145","journal-title":"Chemosphere"},{"issue":"38","key":"12433_CR13","doi-asserted-by":"publisher","first-page":"34136","DOI":"10.1021\/acsomega.2c03453","volume":"7","author":"KE Goodman","year":"2022","unstructured":"Goodman KE, Hua T, Sang QXA (2022) Effects of Polystyrene Microplastics on Human Kidney and Liver Cell Morphology, Cellular Proliferation, and Metabolism. ACS Omega 7(38):34136\u201334153. https:\/\/doi.org\/10.1021\/acsomega.2c03453","journal-title":"ACS Omega"},{"key":"12433_CR14","doi-asserted-by":"publisher","first-page":"132631","DOI":"10.1016\/j.chemosphere.2021","volume":"288","author":"X Meng","year":"2022","unstructured":"Meng X, Zhang J, Wang W, Gonzalez-Gil G, Vrouwenvelder JS, Li Z (2022) Effects of nano- and microplastics on kidney: Physicochemical properties, bioaccumulation, oxidative stress and immunoreaction. Chemosphere 288:132631. https:\/\/doi.org\/10.1016\/j.chemosphere.2021","journal-title":"Chemosphere"},{"issue":"1","key":"12433_CR15","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/s41392-023-01570-w","volume":"8","author":"X Chen","year":"2023","unstructured":"Chen X, Shi C, He M, Xiong S, Xia X (2023) Endoplasmic reticulum stress: molecular mechanism and therapeutic targets. Signal Transduct Target Therapy 8(1):352. https:\/\/doi.org\/10.1038\/s41392-023-01570-w","journal-title":"Signal Transduct Target Therapy"},{"key":"12433_CR16","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.ibneur.2025.05.011","volume":"18","author":"YX He","year":"2025","unstructured":"He YX, Zhang ZQ, Zheng XX, Huang F, He G, Yu XC, Xu AC (2025) CHPG's role in regulating apoptosis in heat-stressed microglia through endoplasmic reticulum stress: A new perspective\u2606. IBRO Neurosci Rep 18:823\u2013829. https:\/\/doi.org\/10.1016\/j.ibneur.2025.05.011","journal-title":"IBRO Neurosci Rep"},{"issue":"1","key":"12433_CR17","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s10571-016-0344-5","volume":"37","author":"A Jangra","year":"2017","unstructured":"Jangra A, Sriram CS, Dwivedi S, Gurjar SS, Hussain MI, Borah P, Lahkar M (2017) Sodium Phenylbutyrate and Edaravone Abrogate Chronic Restraint Stress-Induced Behavioral Deficits: Implication of Oxido-Nitrosative, Endoplasmic Reticulum Stress Cascade, and Neuroinflammation. Cell Mol Neurobiol 37(1):65\u201381. https:\/\/doi.org\/10.1007\/s10571-016-0344-5","journal-title":"Cell Mol Neurobiol"},{"key":"12433_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15376516.2026.2664035","volume":"7","author":"R Yadav","year":"2026","unstructured":"Yadav R, Jangra A, Dhingra D, Kushwaha S, Dubey I, Kumar D (2026) Nephroprotective role of edaravone against polystyrene nanoplastic-induced endoplasmic reticulum stress in Wistar rats. Toxicol Mech Methods 7:1\u201315. https:\/\/doi.org\/10.1080\/15376516.2026.2664035","journal-title":"Toxicol Mech Methods"},{"key":"12433_CR19","doi-asserted-by":"publisher","first-page":"109068","DOI":"10.1016\/j.reprotox.2025.109068","volume":"138","author":"J Singh","year":"2025","unstructured":"Singh J, Jangra A, Kushwaha S, Dubey I, Dhingra D, Kumar D (2025) Melatonin alleviates Di-2-ethylhexyl phthalate induced male reproductive toxicity through inhibition of endoplasmic reticulum stress: Behavioral, biochemical, and morphological evidences. Reprod Toxicol 138:109068. https:\/\/doi.org\/10.1016\/j.reprotox.2025.109068","journal-title":"Reprod Toxicol"},{"key":"12433_CR20","doi-asserted-by":"publisher","first-page":"113818","DOI":"10.1016\/j.foodres.2023.113818","volume":"175","author":"Z Wang","year":"2024","unstructured":"Wang Z, Liu S, Cheng Z, Xu G, Li F, Bu Q, Zhang L, Song Y, An X (2024) Endoplasmic reticulum stress exacerbates microplastics-induced toxicity in animal cells. Food Res Int 175:113818. https:\/\/doi.org\/10.1016\/j.foodres.2023.113818","journal-title":"Food Res Int"},{"issue":"6","key":"12433_CR21","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1021\/acschemneuro.4c00709","volume":"16","author":"K Baffour","year":"2025","unstructured":"Baffour K, Koti N, Nyabayo T, Balerao S, Sutton C, Johnson D, Patel R, Santra S, Banerjee T (2025) Modulation of \u03b1-Synuclein Fibrillation and Toxicity by 4-Phenylbutyric Acid. ACS Chem Neurosci 16(6):1066\u20131078. https:\/\/doi.org\/10.1021\/acschemneuro.4c00709","journal-title":"ACS Chem Neurosci"},{"issue":"1","key":"12433_CR22","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41420-025-02476-y","volume":"11","author":"R Omar","year":"2025","unstructured":"Omar R, Lee MAW, Gonzalez-Trueba L, Thomson CR, Hansen U, Lianos S, Hazarika S, Abdallah E, El O, Ammar MA, Cassels J, Michie AM, Bulleid NJ, Malfait F, Van Agtmael T (2025) The chemical chaperone 4-phenylbutyric acid rescues molecular cell defects of COL3A1 mutations that cause vascular Ehlers Danlos Syndrome. Cell Death Discovery 11(1):200. https:\/\/doi.org\/10.1038\/s41420-025-02476-y","journal-title":"Cell Death Discovery"},{"key":"12433_CR23","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.optmat.2017.03.020","volume":"66","author":"WK Kuo","year":"2017","unstructured":"Kuo WK, Lin SY, Hsu SW, Yu HH (2017) Fabrication and investigation of the bionic curved visual microlens array films. Opt Mater 66:630\u2013639. https:\/\/doi.org\/10.1016\/j.optmat.2017.03.020","journal-title":"Opt Mater"},{"key":"12433_CR24","doi-asserted-by":"publisher","first-page":"121575","DOI":"10.1016\/j.jhazmat.2019.121575","volume":"385","author":"C Dong","year":"2020","unstructured":"Dong C, Di, Chen CW, Chen YC, Chen HH, Lee JS, Lin CH (2020) Polystyrene microplastic particles: In vitro pulmonary toxicity assessment. J Hazard Mater 385:121575. https:\/\/doi.org\/10.1016\/j.jhazmat.2019.121575","journal-title":"J Hazard Mater"},{"key":"12433_CR25","doi-asserted-by":"publisher","first-page":"127709","DOI":"10.1016\/j.envpol.2026.127709","volume":"393","author":"A Lafram","year":"2026","unstructured":"Lafram A, Laadraoui J, Al Naggar Y, Sabri S, Roky R (2026) Sex-based differences in toxicity after exposure to microplastics or nanoplastics in aquatic and terrestrial organisms: A systematic review. Environ Pollut 393:127709. https:\/\/doi.org\/10.1016\/j.envpol.2026.127709","journal-title":"Environ Pollut"},{"issue":"7","key":"12433_CR26","doi-asserted-by":"publisher","first-page":"9817","DOI":"10.1007\/s00210-026-04997-4","volume":"399","author":"P Portakal","year":"2026","unstructured":"Portakal P, G\u00fcrk\u00f6k-Tan T (2026) Sex-dependent transcriptional responses and druggable targets in gentamicin-induced nephrotoxicity. Naunyn Schmiedebergs Arch Pharmacol 399(7):9817\u20139829. https:\/\/doi.org\/10.1007\/s00210-026-04997-4","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"1","key":"12433_CR27","doi-asserted-by":"publisher","first-page":"34783","DOI":"10.1038\/s41598-025-18550-5","volume":"15","author":"YY Hwang","year":"2025","unstructured":"Hwang YY, Tsen QT, Felim J, Shiu RF, Kong F, Kong ZL, Hwang DF (2025) Probiotics as a therapeutic approach to alleviate reproductive harm from polystyrene microplastics in male rats. Sci Rep 15(1):34783. https:\/\/doi.org\/10.1038\/s41598-025-18550-5","journal-title":"Sci Rep"},{"issue":"1","key":"12433_CR28","doi-asserted-by":"publisher","first-page":"14057","DOI":"10.1038\/s41598-023-38584-x","volume":"13","author":"L Jia","year":"2023","unstructured":"Jia L, Jingzhen Z, Xinliang Y, Bishao S, Xin L, Ji Z, Zhenqiang F (2023) 4-PBA inhibits endoplasmic reticulum stress to improve autophagic flux in the treatment of protamine\/lipopolysaccharide-induced interstitial cystitis in rats. Sci Rep 13(1):14057. https:\/\/doi.org\/10.1038\/s41598-023-38584-x","journal-title":"Sci Rep"},{"issue":"22","key":"12433_CR29","doi-asserted-by":"publisher","first-page":"63185","DOI":"10.1007\/s11356-023-26565-6","volume":"30","author":"A Saeed","year":"2023","unstructured":"Saeed A, Akhtar MF, Saleem A, Akhtar B, Sharif A (2023) Reproductive and metabolic toxic effects of polystyrene microplastics in adult female Wistar rats: a mechanistic study. Environ Sci Pollut Res 30(22):63185\u201363199. https:\/\/doi.org\/10.1007\/s11356-023-26565-6","journal-title":"Environ Sci Pollut Res"},{"issue":"16","key":"12433_CR30","doi-asserted-by":"publisher","first-page":"22116","DOI":"10.18632\/oncotarget.7904","volume":"7","author":"SH Liu","year":"2016","unstructured":"Liu SH, Yang CC, Chan DC, Wu CT, Chen LP, Huang JW, Hung KY, Chiang CK (2016) Chemical chaperon 4-phenylbutyrate protects against the endoplasmic reticulum stress-mediated renal fibrosis in vivo and in vitro. Oncotarget 7(16):22116\u201322127. https:\/\/doi.org\/10.18632\/oncotarget.7904","journal-title":"Oncotarget"},{"issue":"2","key":"12433_CR31","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1006\/abio.1994.1112","volume":"217","author":"O Lowry","year":"1994","unstructured":"Lowry O, Schagger H, Cramer WA, Vonjagow G (1994) Protein Measurement With the Folin Phenol Reagent. Anal Biochem 217(2):220\u2013230. http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003269784711122","journal-title":"Anal Biochem"},{"issue":"2","key":"12433_CR32","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95(2):351\u2013358. https:\/\/doi.org\/10.1016\/0003-2697(79)90738-3","journal-title":"Anal Biochem"},{"key":"12433_CR33","first-page":"882","volume":"61","author":"E BEUTLER","year":"1963","unstructured":"BEUTLER E, DURON, O., KELLY BM (1963) Improved method for the determination of blood glutathione. J Lab Clin Med 61:882\u2013888","journal-title":"J Lab Clin Med"},{"issue":"1","key":"12433_CR34","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","volume":"126","author":"LC Green","year":"1982","unstructured":"Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR (1982) Analysis of nitrate, nitrite, and [15\u00a0N]nitrate in biological fluids. Anal Biochem 126(1):131\u2013138. https:\/\/doi.org\/10.1016\/0003-2697(82)90118-X","journal-title":"Anal Biochem"},{"key":"12433_CR35","doi-asserted-by":"publisher","first-page":"159164","DOI":"10.1016\/J.SCITOTENV.2022.159164","volume":"856","author":"G Kutralam-Muniasamy","year":"2023","unstructured":"Kutralam-Muniasamy G, Shruti VC, P\u00e9rez-Guevara F, Roy PD (2023) Microplastic diagnostics in humans: The 3Ps Progress, problems, and prospects. Sci Total Environ 856:159164. https:\/\/doi.org\/10.1016\/J.SCITOTENV.2022.159164","journal-title":"Sci Total Environ"},{"key":"12433_CR36","doi-asserted-by":"publisher","first-page":"113772","DOI":"10.1016\/j.ecoenv.2022.113772","volume":"241","author":"J Wang","year":"2022","unstructured":"Wang J, Ding L, Wang K, Huang R, Yu W, Yan B, Wang H, Zhang C, Yang Z, Liu Z (2022) Role of endoplasmic reticulum stress in cadmium-induced hepatocyte apoptosis and the protective effect of quercetin. Ecotoxicol Environ Saf 241:113772. https:\/\/doi.org\/10.1016\/j.ecoenv.2022.113772","journal-title":"Ecotoxicol Environ Saf"},{"issue":"4","key":"12433_CR37","doi-asserted-by":"publisher","first-page":"200178","DOI":"10.1016\/j.ctmp.2024.200178","volume":"5","author":"MO Oyovwi","year":"2024","unstructured":"Oyovwi MO, Rotu AR, Emojevwe VO, Adeogun AE, Udi OA (2024) Investigating the protective effects of epigallocatechin-gallate against polystyrene microplastics-induced biochemical and hematological alterations in rats. Clin Traditional Med Pharmacol 5(4):200178. https:\/\/doi.org\/10.1016\/j.ctmp.2024.200178","journal-title":"Clin Traditional Med Pharmacol"},{"issue":"2","key":"12433_CR38","doi-asserted-by":"publisher","first-page":"027006","DOI":"10.1289\/EHP11072","volume":"131","author":"T Okamura","year":"2023","unstructured":"Okamura T, Hamaguchi M, Hasegawa Y, Hashimoto Y, Majima S, Senmaru T, Ushigome E, Nakanishi N, Asano M, Yamazaki M, Sasano R, Nakanishi Y, Seno H, Takano H, Fukui M (2023) Oral Exposure to Polystyrene Microplastics of Mice on a Normal or High-Fat Diet and Intestinal and Metabolic Outcomes. Environ Health Perspect 131(2):027006. https:\/\/doi.org\/10.1289\/EHP11072","journal-title":"Environ Health Perspect"},{"issue":"22","key":"12433_CR39","doi-asserted-by":"publisher","first-page":"15805","DOI":"10.1021\/acs.est.1c07933","volume":"56","author":"Y Deng","year":"2022","unstructured":"Deng Y, Chen H, Huang Y, Zhang Y, Ren H, Fang M, Wang Q, Chen W, Hale RC, Galloway TS, Chen D (2022) Long-Term Exposure to Environmentally Relevant Doses of Large Polystyrene Microplastics Disturbs Lipid Homeostasis via Bowel Function Interference. Environ Sci Technol 56(22):15805\u201315817. https:\/\/doi.org\/10.1021\/acs.est.1c07933","journal-title":"Environ Sci Technol"},{"issue":"2","key":"12433_CR40","doi-asserted-by":"publisher","first-page":"103044","DOI":"10.1016\/j.jksus.2023","volume":"36","author":"N Ghafoor","year":"2024","unstructured":"Ghafoor N, Ehsan N, Hayat MF, Azmat R, Ahmed M, Ishtiaq A (2024) Aucubin mitigates nonylphenol-induced renal damage by attenuating apoptosis, oxidative stress and histopathological profile. J King Saud Univ - Sci 36(2):103044. https:\/\/doi.org\/10.1016\/j.jksus.2023","journal-title":"J King Saud Univ - Sci"},{"issue":"4","key":"12433_CR41","doi-asserted-by":"publisher","first-page":"437","DOI":"10.3390\/oxygen2040030","volume":"2","author":"AK Aranda-Rivera","year":"2022","unstructured":"Aranda-Rivera AK, Cruz-Gregorio A, Arancibia-Hern\u00e1ndez YL, Hern\u00e1ndez-Cruz EY, Pedraza-Chaverri J (2022) RONS and Oxidative Stress: An Overview of Basic Concepts. Oxygen 2(4):437\u2013478. https:\/\/doi.org\/10.3390\/oxygen2040030","journal-title":"Oxygen"},{"issue":"24","key":"12433_CR42","doi-asserted-by":"publisher","first-page":"4008","DOI":"10.3390\/cells11244008","volume":"11","author":"P Llanos","year":"2022","unstructured":"Llanos P, Palomero J (2022) Reactive Oxygen and Nitrogen Species (RONS) and Cytokines\u2014Myokines Involved in Glucose Uptake and Insulin Resistance in Skeletal Muscle. Cells 11(24):4008. https:\/\/doi.org\/10.3390\/cells11244008","journal-title":"Cells"},{"issue":"11","key":"12433_CR43","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.3390\/antiox12111953","volume":"12","author":"SK Georgiou-Siafis","year":"2023","unstructured":"Georgiou-Siafis SK, Tsiftsoglou AS (2023) The Key Role of GSH in Keeping the Redox Balance in Mammalian Cells: Mechanisms and Significance of GSH in Detoxification via Formation of Conjugates. Antioxidants 12(11):1953. https:\/\/doi.org\/10.3390\/antiox12111953","journal-title":"Antioxidants"},{"issue":"3","key":"12433_CR44","doi-asserted-by":"publisher","first-page":"719","DOI":"10.29261\/pakvetj\/2026.061","volume":"46","author":"N Ghafoor","year":"2026","unstructured":"Ghafoor N, Ehsan N (2026) Renoprotective Potential of Robustaflavone Against Diabetes Induced Kidney Damage Via Regulating Oxidative Stress, Inflammation and Apoptosis. Pakistan Veterinary J 46(3):719\u2013725. https:\/\/doi.org\/10.29261\/pakvetj\/2026.061","journal-title":"Pakistan Veterinary J"},{"key":"12433_CR45","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.freeradbiomed.2020.12.325","volume":"165","author":"M Dromant","year":"2021","unstructured":"Dromant M, Mas-Bargues C, Escriv\u00e1 C, Borr\u00e1s C, Vi\u00f1a J (2021) Lipid peroxidation as measured by chromatographic determination of malondialdehyde. Human plasma reference values in health and disease. Free Radic Biol Med 165:27\u201328. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2020.12.325","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"12433_CR46","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41419-024-06515-x","volume":"15","author":"Y Yang","year":"2024","unstructured":"Yang Y, Lu D, Wang M, Liu G, Feng Y, Ren Y, Sun X, Chen Z, Wang Z (2024) Endoplasmic reticulum stress and the unfolded protein response: emerging regulators in progression of traumatic brain injury. Cell Death Dis 15(2):156. https:\/\/doi.org\/10.1038\/s41419-024-06515-x","journal-title":"Cell Death Dis"},{"key":"12433_CR47","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1146\/annurev-biophys-111622-091309","volume":"52","author":"JLM Kotler","year":"2023","unstructured":"Kotler JLM, Street TO (2023) Mechanisms of Protein Quality Control in the Endoplasmic Reticulum by a Coordinated Hsp40-Hsp70-Hsp90 System. Annual Rev Biophys 52:509\u2013524. https:\/\/doi.org\/10.1146\/annurev-biophys-111622-091309","journal-title":"Annual Rev Biophys"},{"issue":"12","key":"12433_CR48","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1038\/s41418-018-0109-4","volume":"25","author":"X Wang","year":"2018","unstructured":"Wang X, Bi X, Zhang G, Deng Y, Luo X, Xu L, Scherer PE, Ferdous A, Fu G, Gillette TG, Lee AS, Jiang X, Wang ZV (2018) Glucose-regulated protein 78 is essential for cardiac myocyte survival. Cell Death Differ 25(12):2181\u20132194. https:\/\/doi.org\/10.1038\/s41418-018-0109-4","journal-title":"Cell Death Differ"},{"key":"12433_CR49","doi-asserted-by":"publisher","first-page":"152790","DOI":"10.1016\/j.tox.2021.152790","volume":"457","author":"H Wu","year":"2021","unstructured":"Wu H, Zheng S, Zhang J, Xu S, Miao Z (2021) Cadmium induces endoplasmic reticulum stress-mediated apoptosis in pig pancreas via the increase of Th1 cells. Toxicology 457:152790. https:\/\/doi.org\/10.1016\/j.tox.2021.152790","journal-title":"Toxicology"},{"issue":"11","key":"12433_CR50","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1038\/s41594-019-0324-9","volume":"26","author":"MC Kopp","year":"2019","unstructured":"Kopp MC, Larburu N, Durairaj V, Adams CJ, Ali MMU (2019) UPR proteins IRE1 and PERK switch BiP from chaperone to ER stress sensor. Nat Struct Mol Biology 26(11):1053\u20131062. https:\/\/doi.org\/10.1038\/s41594-019-0324-9","journal-title":"Nat Struct Mol Biology"},{"issue":"4","key":"12433_CR51","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1097\/MNH.0000000000000141","volume":"24","author":"M Taniguchi","year":"2015","unstructured":"Taniguchi M, Yoshida H (2015) Endoplasmic reticulum stress in kidney function and disease. Curr Opin Nephrol Hypertens 24(4):345\u2013350. https:\/\/doi.org\/10.1097\/MNH.0000000000000141","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"12433_CR52","doi-asserted-by":"publisher","first-page":"112027","DOI":"10.1016\/j.fct.2021.112027","volume":"149","author":"X Zhang","year":"2021","unstructured":"Zhang X, Wang Y, Yang X, Liu M, Huang W, Zhang J, Song M, Shao B, Li Y (2021) The nephrotoxicity of T-2 toxin in mice caused by oxidative stress-mediated apoptosis is related to Nrf2 pathway. Food Chem Toxicol 149:112027. https:\/\/doi.org\/10.1016\/j.fct.2021.112027","journal-title":"Food Chem Toxicol"},{"issue":"5","key":"12433_CR53","doi-asserted-by":"publisher","first-page":"981","DOI":"10.3390\/antiox12050981","volume":"12","author":"G Ong","year":"2023","unstructured":"Ong G, Logue SE (2023) Unfolding the Interactions between Endoplasmic Reticulum Stress and Oxidative Stress. Antioxidants 12(5):981. https:\/\/doi.org\/10.3390\/antiox12050981","journal-title":"Antioxidants"},{"key":"12433_CR54","doi-asserted-by":"publisher","first-page":"116946","DOI":"10.1016\/j.ecoenv.2024.116946","volume":"284","author":"Y Wang","year":"2024","unstructured":"Wang Y, Li Y, Wu Y, Wu A, Xiao B, Liu X, Zhang Q, Feng Y, Yuan Z, Yi J, Wu J, Yang C (2024) Endoplasmic reticulum stress promotes oxidative stress, inflammation, and apoptosis: A novel mechanism of citrinin-induced renal injury and dysfunction. Ecotoxicol Environ Saf 284:116946. https:\/\/doi.org\/10.1016\/j.ecoenv.2024.116946","journal-title":"Ecotoxicol Environ Saf"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12433-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12433-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12433-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T21:02:31Z","timestamp":1784581351000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12433-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,20]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12433"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12433-2","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,20]]},"assertion":[{"value":"27 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All female Wistar albino rats were approved by the Institutional Animal Ethics Committee [Protocol number IAEC\/2024\/PhD_04] of GJUST (Guru Jambheshwar University of Science and Technology), Hisar. The animals were sourced from Lala Lajpat Rai University of Veterinary and Animal Sciences in Hisar and housed at the Experimental Animal Facility at GJUST, Hisar.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1209"}}