{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:08:53Z","timestamp":1784808533689,"version":"3.55.0"},"reference-count":83,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2308085MH262"],"award-info":[{"award-number":["2308085MH262"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12459-6","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:55:00Z","timestamp":1784807700000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Applications and prospects of the immunomodulatory and regenerative capabilities of gingival mesenchymal stem cells for chronic inflammation treatment"],"prefix":"10.1007","volume":"53","author":[{"given":"Xinran","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingji","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"12459_CR1","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.3390\/ijms20092147","volume":"20","author":"D Michels da Silva","year":"2019","unstructured":"Michels da Silva D, Langer H, Graf T (2019) Inflammatory and molecular pathways in heart failure-ischemia, HFpEF and transthyretin cardiac amyloidosis. Int J Mol Sci 20:2147. https:\/\/doi.org\/10.3390\/ijms20092147","journal-title":"Int J Mol Sci"},{"key":"12459_CR2","doi-asserted-by":"publisher","first-page":"116464","DOI":"10.1016\/j.lfs.2019.116464","volume":"236","author":"X Zhang","year":"2019","unstructured":"Zhang X, Wu X, Hu Q, Wu J, Wang G, Hong Z et al (2019) Mitochondrial DNA in liver inflammation and oxidative stress. Life Sci 236:116464. https:\/\/doi.org\/10.1016\/j.lfs.2019.116464","journal-title":"Life Sci"},{"key":"12459_CR3","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/prd.70011","volume":"93","author":"LJ Su\u00e1rez","year":"2025","unstructured":"Su\u00e1rez LJ, Arce RM, Furquim CP, Gon\u00e7alves C, Kantarci A, Feres M et al (2025) Antibiotic-mediated immune modulation in periodontitis. Periodontol 2000 93:13\u201332. https:\/\/doi.org\/10.1111\/prd.70011","journal-title":"Periodontol 2000"},{"key":"12459_CR4","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s12254-025-01077-w","volume":"18","author":"C Dosser","year":"2025","unstructured":"Dosser C, Wolf D, Zimmer K (2025) Chronic inflammation and cancer: ASCO 2025 update. Memo 18:311\u2013315. https:\/\/doi.org\/10.1007\/s12254-025-01077-w","journal-title":"Memo"},{"key":"12459_CR5","doi-asserted-by":"publisher","unstructured":"Colebatch AN, Marks JL, Edwards CJ (2011) Safety of non-steroidal anti-inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving methotrexate for inflammatory arthritis. Cochrane Database Syst Rev CD008872. https:\/\/doi.org\/10.1002\/14651858.CD008872.pub2","DOI":"10.1002\/14651858.CD008872.pub2"},{"key":"12459_CR6","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1093\/rheumatology\/kes032","volume":"51","author":"SL Whittle","year":"2012","unstructured":"Whittle SL, Colebatch AN, Buchbinder R, Edwards CJ, Adams K, Englbrecht M et al (2012) Multinational evidence-based recommendations for pain management by pharmacotherapy in inflammatory arthritis. Rheumatology (Oxford) 51:1416\u20131425. https:\/\/doi.org\/10.1093\/rheumatology\/kes032","journal-title":"Rheumatology (Oxford)"},{"key":"12459_CR7","doi-asserted-by":"publisher","unstructured":"Marks JL, Colebatch AN, Buchbinder R, Edwards CJ (2011) Pain management for rheumatoid arthritis and cardiovascular or renal comorbidity. Cochrane Database Syst Rev CD008952. https:\/\/doi.org\/10.1002\/14651858.CD008952.pub2","DOI":"10.1002\/14651858.CD008952.pub2"},{"key":"12459_CR8","doi-asserted-by":"publisher","first-page":"103263","DOI":"10.1016\/j.jaut.2024.103263","volume":"147","author":"CS Martin","year":"2024","unstructured":"Martin CS, Crastin A, Sagmeister MS, Kalirai MS, Turner JD, MacDonald L et al (2024) Inflammation dynamically regulates steroid hormone metabolism and action within macrophages in rheumatoid arthritis. J Autoimmun 147:103263. https:\/\/doi.org\/10.1016\/j.jaut.2024.103263","journal-title":"J Autoimmun"},{"key":"12459_CR9","doi-asserted-by":"publisher","first-page":"j1415","DOI":"10.1136\/bmj.j1415","volume":"357","author":"AK Waljee","year":"2017","unstructured":"Waljee AK, Rogers MA, Lin P, Singal AG, Stein JD, Marks RM et al (2017) Short term use of oral corticosteroids and related harms among adults in the United States: population based cohort study. BMJ 357:j1415. https:\/\/doi.org\/10.1136\/bmj.j1415","journal-title":"BMJ"},{"key":"12459_CR10","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/nrrheum.2014.64","volume":"10","author":"DA Walsh","year":"2014","unstructured":"Walsh DA, McWilliams DF (2014) Mechanisms, impact and management of pain in rheumatoid arthritis. Nat Rev Rheumatol 10:581\u2013592. https:\/\/doi.org\/10.1038\/nrrheum.2014.64","journal-title":"Nat Rev Rheumatol"},{"key":"12459_CR11","doi-asserted-by":"publisher","first-page":"13625","DOI":"10.1073\/pnas.240309797","volume":"97","author":"S Gronthos","year":"2000","unstructured":"Gronthos S, Mankani M, Brahim J, Robey PG, Shi S (2000) Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A 97:13625\u201313630. https:\/\/doi.org\/10.1073\/pnas.240309797","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12459_CR12","doi-asserted-by":"publisher","first-page":"7787","DOI":"10.4049\/jimmunol.0902318","volume":"183","author":"Q Zhang","year":"2009","unstructured":"Zhang Q, Shi S, Liu Y, Uyanne J, Shi Y, Shi S et al (2009) Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis. J Immunol 183:7787\u20137798. https:\/\/doi.org\/10.4049\/jimmunol.0902318","journal-title":"J Immunol"},{"key":"12459_CR13","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.ijbiomac.2021.02.145","volume":"178","author":"T Lei","year":"2021","unstructured":"Lei T, Wang J, Liu Y, Chen P, Zhang Z, Zhang X et al (2021) Calreticulin as a special marker to distinguish dental pulp stem cells from gingival mesenchymal stem cells. Int J Biol Macromol 178:229\u2013239. https:\/\/doi.org\/10.1016\/j.ijbiomac.2021.02.145","journal-title":"Int J Biol Macromol"},{"key":"12459_CR14","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.archoralbio.2010.12.008","volume":"56","author":"A Bakopoulou","year":"2011","unstructured":"Bakopoulou A, Leyhausen G, Volk J, Tsiftsoglou A, Garefis P, Koidis P et al (2011) Comparative analysis of in vitro osteo\/odontogenic differentiation potential of human DPSCs and SCAP. Arch Oral Biol 56:709\u2013721. https:\/\/doi.org\/10.1016\/j.archoralbio.2010.12.008","journal-title":"Arch Oral Biol"},{"key":"12459_CR15","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/scrt5","volume":"1","author":"T Yamaza","year":"2010","unstructured":"Yamaza T, Kentaro A, Chen C, Liu Y, Shi Y, Gronthos S et al (2010) Immunomodulatory properties of stem cells from human exfoliated deciduous teeth. Stem Cell Res Ther 1:5. https:\/\/doi.org\/10.1186\/scrt5","journal-title":"Stem Cell Res Ther"},{"key":"12459_CR16","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0140-6736(04)16627-0","volume":"364","author":"BM Seo","year":"2004","unstructured":"Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J et al (2004) Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 364:149\u2013155. https:\/\/doi.org\/10.1016\/S0140-6736(04)16627-0","journal-title":"Lancet"},{"key":"12459_CR17","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.matbio.2004.12.004","volume":"24","author":"C Morsczeck","year":"2005","unstructured":"Morsczeck C, G\u00f6tz W, Schierholz J, Zeilhofer F, K\u00fchn U, M\u00f6hl C et al (2005) Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth. Matrix Biol 24:155\u2013165. https:\/\/doi.org\/10.1016\/j.matbio.2004.12.004","journal-title":"Matrix Biol"},{"key":"12459_CR18","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1359\/JBMR.041117","volume":"20","author":"T Matsubara","year":"2005","unstructured":"Matsubara T, Suardita K, Ishii M, Sugiyama M, Igarashi A, Oda R et al (2005) Alveolar bone marrow as a cell source for regenerative medicine. J Bone Min Res 20:399\u2013409. https:\/\/doi.org\/10.1359\/JBMR.041117","journal-title":"J Bone Min Res"},{"key":"12459_CR19","doi-asserted-by":"publisher","first-page":"635055","DOI":"10.3389\/froh.2021.635055","volume":"2","author":"A Paganelli","year":"2021","unstructured":"Paganelli A, Trubiani O, Diomede F, Pisciotta A, Paganelli R (2021) Immunomodulating profile of dental mesenchymal stromal cells. Front Oral Health 2:635055. https:\/\/doi.org\/10.3389\/froh.2021.635055","journal-title":"Front Oral Health"},{"key":"12459_CR20","doi-asserted-by":"publisher","first-page":"667221","DOI":"10.3389\/fimmu.2021.667221","volume":"12","author":"D Kim","year":"2021","unstructured":"Kim D, Lee AE, Xu Q, Zhang Q, Le AD (2021) Gingiva-derived mesenchymal stem cells: potential application in tissue engineering and regenerative medicine -- a comprehensive review. Front Immunol 12:667221. https:\/\/doi.org\/10.3389\/fimmu.2021.667221","journal-title":"Front Immunol"},{"key":"12459_CR21","doi-asserted-by":"publisher","first-page":"eabm6504","DOI":"10.1126\/sciadv.abm6504","volume":"8","author":"JR Dave","year":"2022","unstructured":"Dave JR, Chandekar SS, Behera S, Desai KU, Salve PM, Sapkal NB et al (2022) Human gingival mesenchymal stem cells retain their growth and immunomodulatory characteristics independent of donor age. Sci Adv 8:eabm6504. https:\/\/doi.org\/10.1126\/sciadv.abm6504","journal-title":"Sci Adv"},{"key":"12459_CR22","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","volume":"8","author":"M Dominici","year":"2006","unstructured":"Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D et al (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. Cytotherapy 8:315\u2013317. https:\/\/doi.org\/10.1080\/14653240600855905","journal-title":"Cytotherapy"},{"key":"12459_CR23","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.biomaterials.2018.04.019","volume":"172","author":"J Isaac","year":"2018","unstructured":"Isaac J, Nassif A, Asselin A, Ta\u00efhi I, Fohrer-Ting H, Klein C et al (2018) Involvement of neural crest and paraxial mesoderm in oral mucosal development and healing. Biomaterials 172:41\u201353. https:\/\/doi.org\/10.1016\/j.biomaterials.2018.04.019","journal-title":"Biomaterials"},{"key":"12459_CR24","doi-asserted-by":"publisher","first-page":"345","DOI":"10.2174\/1574888X13666180226105410","volume":"13","author":"F Huang","year":"2018","unstructured":"Huang F, Liu ZM, Zheng SG (2018) Updates on GMSCs treatment for autoimmune diseases. Curr Stem Cell Res Ther 13:345\u2013349. https:\/\/doi.org\/10.2174\/1574888X13666180226105410","journal-title":"Curr Stem Cell Res Ther"},{"key":"12459_CR25","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41581-018-0023-5","volume":"14","author":"Y Shi","year":"2018","unstructured":"Shi Y, Wang Y, Li Q, Liu K, Hou J, Shao C et al (2018) Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases. Nat Rev Nephrol 14:493\u2013507. https:\/\/doi.org\/10.1038\/s41581-018-0023-5","journal-title":"Nat Rev Nephrol"},{"key":"12459_CR26","doi-asserted-by":"publisher","first-page":"3323","DOI":"10.1007\/s00018-019-03125-1","volume":"76","author":"A Naji","year":"2019","unstructured":"Naji A, Eitoku M, Favier B, Deschaseaux F, Rouas-Freiss N, Suganuma N (2019) Biological functions of mesenchymal stem cells and clinical implications. Cell Mol Life Sci 76:3323\u20133348. https:\/\/doi.org\/10.1007\/s00018-019-03125-1","journal-title":"Cell Mol Life Sci"},{"key":"12459_CR27","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1136\/annrheumdis-2020-217311","volume":"79","author":"X He","year":"2020","unstructured":"He X, Yang Y, Yao M, Yang L, Ao L, Hu X et al (2020) Combination of human umbilical cord mesenchymal stem cell transplantation with IFN-\u03b3 treatment synergistically improves clinical outcomes of patients with RA. Ann Rheum Dis 79:1298\u20131304. https:\/\/doi.org\/10.1136\/annrheumdis-2020-217311","journal-title":"Ann Rheum Dis"},{"key":"12459_CR28","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1016\/j.jaci.2016.09.025","volume":"139","author":"T Vigo","year":"2017","unstructured":"Vigo T, Procaccini C, Ferrara G, Baranzini S, Oksenberg JR, Matarese G et al (2017) IFN-\u03b3 orchestrates mesenchymal stem cell plasticity through STAT1 and STAT3 and mTOR pathways. J Allergy Clin Immunol 139:1667\u20131676. https:\/\/doi.org\/10.1016\/j.jaci.2016.09.025","journal-title":"J Allergy Clin Immunol"},{"key":"12459_CR29","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41392-022-00926-0","volume":"7","author":"Y Han","year":"2022","unstructured":"Han Y, Yang J, Fang J, Zhou Y, Candi E, Wang J et al (2022) The secretion profile of mesenchymal stem cells and potential applications in treating human diseases. Signal Transduct Target Ther 7:92. https:\/\/doi.org\/10.1038\/s41392-022-00926-0","journal-title":"Signal Transduct Target Ther"},{"key":"12459_CR30","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1002\/stem.1985","volume":"33","author":"M Mounayar","year":"2015","unstructured":"Mounayar M, Kefaloyianni E, Smith B, Solhjou Z, Maarouf OH, Azzi J et al (2015) PI3k\u03b1 and STAT1 interplay regulates human mesenchymal stem cell immune polarization. Stem Cells 33:1892\u20131901. https:\/\/doi.org\/10.1002\/stem.1985","journal-title":"Stem Cells"},{"key":"12459_CR31","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3389\/fimmu.2017.00068","volume":"8","author":"F Huang","year":"2017","unstructured":"Huang F, Chen M, Chen W, Gu J, Yuan J, Xue Y et al (2017) Human gingiva-derived mesenchymal stem cells inhibit xeno-graft-versus-host disease via CD39-CD73-adenosine and IDO signals. Front Immunol 8:68. https:\/\/doi.org\/10.3389\/fimmu.2017.00068","journal-title":"Front Immunol"},{"key":"12459_CR32","doi-asserted-by":"publisher","first-page":"102491","DOI":"10.1016\/j.jaut.2020.102491","volume":"113","author":"J Dang","year":"2020","unstructured":"Dang J, Xu Z, Xu A, Liu Y, Fu Q, Wang J et al (2020) Human gingiva-derived mesenchymal stem cells are therapeutic in lupus nephritis through targeting of CD39-CD73 signaling pathway. J Autoimmun 113:102491. https:\/\/doi.org\/10.1016\/j.jaut.2020.102491","journal-title":"J Autoimmun"},{"key":"12459_CR33","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1002\/stem.722","volume":"29","author":"WR Su","year":"2011","unstructured":"Su WR, Zhang QZ, Shi SH, Nguyen AL, Le AD (2011) Human gingiva-derived mesenchymal stromal cells attenuate contact hypersensitivity via prostaglandin E2-dependent mechanisms. Stem Cells 29:1849\u20131860. https:\/\/doi.org\/10.1002\/stem.722","journal-title":"Stem Cells"},{"key":"12459_CR34","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1002\/art.37877","volume":"65","author":"M Chen","year":"2013","unstructured":"Chen M, Su W, Lin X, Guo Z, Wang J, Zhang Q et al (2013) Adoptive transfer of human gingiva-derived mesenchymal stem cells ameliorates collagen-induced arthritis via suppression of Th1 and Th17 cells and enhancement of regulatory T cell differentiation. Arthritis Rheum 65:1181\u20131193. https:\/\/doi.org\/10.1002\/art.37877","journal-title":"Arthritis Rheum"},{"key":"12459_CR35","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1111\/jcmm.17109","volume":"26","author":"X Tian","year":"2022","unstructured":"Tian X, Wei W, Cao Y, Ao T, Huang F, Javed R et al (2022) Gingival mesenchymal stem cell-derived exosomes are immunosuppressive in preventing collagen-induced arthritis. J Cell Mol Med 26:693\u2013708. https:\/\/doi.org\/10.1111\/jcmm.17109","journal-title":"J Cell Mol Med"},{"key":"12459_CR36","doi-asserted-by":"publisher","first-page":"e171932","DOI":"10.1172\/jci.insight.171932","volume":"9","author":"J Chen","year":"2024","unstructured":"Chen J, Shi X, Deng Y, Dang J, Liu Y, Zhao J et al (2024) miRNA-148a-containing GMSC-derived EVs modulate Treg\/Th17 balance via IKKB\/NF-\u03baB pathway and treat a rheumatoid arthritis model. JCI Insight 9:e171932. https:\/\/doi.org\/10.1172\/jci.insight.171932","journal-title":"JCI Insight"},{"key":"12459_CR37","doi-asserted-by":"publisher","first-page":"109818","DOI":"10.1016\/j.isci.2024.109818","volume":"27","author":"Q Fang","year":"2024","unstructured":"Fang Q, Wu W, Xiao Z, Zeng D, Liang R, Wang J et al (2024) Gingival-derived mesenchymal stem cells alleviate allergic asthma inflammation via HGF in animal models. iScience 27:109818. https:\/\/doi.org\/10.1016\/j.isci.2024.109818","journal-title":"iScience"},{"key":"12459_CR38","doi-asserted-by":"publisher","first-page":"429","DOI":"10.3389\/fcimb.2019.00429","volume":"9","author":"W Kang","year":"2019","unstructured":"Kang W, Wang T, Hu Z, Liu F, Gao Y, Yang P et al (2019) Persistent exposure to Fusobacterium nucleatum triggers chemokine\/cytokine release and inhibits the proliferation and osteogenic differentiation capabilities of human gingiva-derived mesenchymal stem cells. Front Cell Infect Microbiol 9:429. https:\/\/doi.org\/10.3389\/fcimb.2019.00429","journal-title":"Front Cell Infect Microbiol"},{"key":"12459_CR39","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1111\/jcpe.13798","volume":"50","author":"Y Hu","year":"2023","unstructured":"Hu Y, Wang Z, Fan C, Gao P, Wang W, Xie Y et al (2023) Human gingival mesenchymal stem cell-derived exosomes cross-regulate the Wnt\/\u03b2-catenin and NF-\u03baB signalling pathways in the periodontal inflammation microenvironment. J Clin Periodontol 50:796\u2013806. https:\/\/doi.org\/10.1111\/jcpe.13798","journal-title":"J Clin Periodontol"},{"key":"12459_CR40","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.actbio.2020.12.043","volume":"122","author":"Y Nakao","year":"2021","unstructured":"Nakao Y, Fukuda T, Zhang Q, Sanui T, Shinjo T, Kou X et al (2021) Exosomes from TNF-\u03b1-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss. Acta Biomater 122:306\u2013324. https:\/\/doi.org\/10.1016\/j.actbio.2020.12.043","journal-title":"Acta Biomater"},{"key":"12459_CR41","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1002\/stem.503","volume":"28","author":"QZ Zhang","year":"2010","unstructured":"Zhang QZ, Su WR, Shi SH, Wilder-Smith P, Xiang AP, Wong A et al (2010) Human gingiva-derived mesenchymal stem cells elicit polarization of M2 macrophages and enhance cutaneous wound healing. Stem Cells 28:1856\u20131868. https:\/\/doi.org\/10.1002\/stem.503","journal-title":"Stem Cells"},{"key":"12459_CR42","doi-asserted-by":"publisher","first-page":"13344","DOI":"10.1038\/s41598-022-17728-5","volume":"12","author":"Y Watanabe","year":"2022","unstructured":"Watanabe Y, Fukuda T, Hayashi C, Nakao Y, Toyoda M, Kawakami K et al (2022) Extracellular vesicles derived from GMSCs stimulated with TNF-\u03b1 and IFN-\u03b1 promote M2 macrophage polarization via enhanced CD73 and CD5L expression. Sci Rep 12:13344. https:\/\/doi.org\/10.1038\/s41598-022-17728-5","journal-title":"Sci Rep"},{"key":"12459_CR43","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1111\/jcpe.14184","volume":"52","author":"J Wang","year":"2025","unstructured":"Wang J, Hu Y, Wang Z, Fan C, Liu Y, Xie Y et al (2025) Exosomes derived from human gingival mesenchymal stem cells induce metabolic reprogramming of inflammatory macrophages. J Clin Periodontol 52:1196\u20131210. https:\/\/doi.org\/10.1111\/jcpe.14184","journal-title":"J Clin Periodontol"},{"key":"12459_CR44","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.jare.2023.05.005","volume":"58","author":"J Zhao","year":"2024","unstructured":"Zhao J, Liu Y, Shi X, Dang J, Liu Y, Li S et al (2024) Infusion of GMSCs relieves autoimmune arthritis by suppressing the externalization of neutrophil extracellular traps via PGE2-PKA-ERK axis. J Adv Res 58:79\u201391. https:\/\/doi.org\/10.1016\/j.jare.2023.05.005","journal-title":"J Adv Res"},{"key":"12459_CR45","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.ebiom.2019.04.034","volume":"43","author":"Y Luo","year":"2019","unstructured":"Luo Y, Wu W, Gu J, Zhang X, Dang J, Wang J et al (2019) Human gingival tissue-derived MSC suppress osteoclastogenesis and bone erosion via CD39-adenosine signal pathway in autoimmune arthritis. EBioMedicine 43:620\u2013631. https:\/\/doi.org\/10.1016\/j.ebiom.2019.04.034","journal-title":"EBioMedicine"},{"key":"12459_CR46","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.adaj.2018.04.023","volume":"149","author":"PI Eke","year":"2018","unstructured":"Eke PI, Thornton-Evans GO, Wei L, Borgnakke WS, Dye BA, Genco RJ et al (2018) Periodontitis in US adults: National Health and Nutrition Examination Survey 2009\u20132014. J Am Dent Assoc 149:576\u2013588","journal-title":"J Am Dent Assoc"},{"key":"12459_CR47","doi-asserted-by":"publisher","first-page":"27789","DOI":"10.1038\/s41598-024-78729-8","volume":"14","author":"KK Ghadge","year":"2024","unstructured":"Ghadge KK, Shetty SK, Kharat A, Kheur S, Kulloli A, Gopalakrishnan D et al (2024) Translational implications of a novel combination of iPRF and collagen scaffold for proliferation of gingival mesenchymal stem cells. Sci Rep 14:27789. https:\/\/doi.org\/10.1038\/s41598-024-78729-8","journal-title":"Sci Rep"},{"key":"12459_CR48","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.3892\/etm.2019.7165","volume":"17","author":"W Sun","year":"2019","unstructured":"Sun W, Wang Z, Xu Q, Sun H, Liu X, Yang J et al (2019) The treatment of systematically transplanted gingival mesenchymal stem cells in periodontitis in mice. Exp Ther Med 17:2199\u20132205. https:\/\/doi.org\/10.3892\/etm.2019.7165","journal-title":"Exp Ther Med"},{"key":"12459_CR49","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1089\/ten.TEC.2024.0169","volume":"30","author":"E Kord-Parijaee","year":"2024","unstructured":"Kord-Parijaee E, Ferdosi-Shahandashti E, Bakhshandeh B, Pournajaf A (2024) Enhancing gingival-derived mesenchymal stem cell potential in tissue engineering and regenerative medicine through paraprobiotics. Tissue Eng Part C Methods 30:512\u2013521. https:\/\/doi.org\/10.1089\/ten.TEC.2024.0169","journal-title":"Tissue Eng Part C Methods"},{"key":"12459_CR50","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13287-020-1565-6","volume":"11","author":"J Qiu","year":"2020","unstructured":"Qiu J, Wang X, Zhou H, Zhang C, Wang Y, Huang J et al (2020) Enhancement of periodontal tissue regeneration by conditioned media from gingiva-derived or periodontal ligament-derived mesenchymal stem cells. Stem Cell Res Ther 11:42. https:\/\/doi.org\/10.1186\/s13287-020-1565-6","journal-title":"Stem Cell Res Ther"},{"key":"12459_CR51","doi-asserted-by":"publisher","first-page":"2102593","DOI":"10.1002\/adhm.202102593","volume":"11","author":"J Zarubova","year":"2022","unstructured":"Zarubova J, Hasani-Sadrabadi MM, Dashtimoghadam E, Zhang X, Ansari S, Li S et al (2022) Engineered delivery of dental stem-cell-derived extracellular vesicles for periodontal tissue regeneration. Adv Healthc Mater 11:2102593. https:\/\/doi.org\/10.1002\/adhm.202102593","journal-title":"Adv Healthc Mater"},{"key":"12459_CR52","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1039\/D2NA00760B","volume":"5","author":"Z Liu","year":"2023","unstructured":"Liu Z, Yang S, Li X, Wang S, Zhang T, Huo N et al (2023) Local transplantation of GMSC-derived exosomes to promote vascularized diabetic wound healing by regulating the Wnt\/\u03b2-catenin pathways. Nanoscale Adv 5:916\u2013926. https:\/\/doi.org\/10.1039\/D2NA00760B","journal-title":"Nanoscale Adv"},{"key":"12459_CR53","doi-asserted-by":"publisher","first-page":"11973","DOI":"10.1007\/s11033-022-07979-6","volume":"49","author":"A Kharat","year":"2022","unstructured":"Kharat A, Chandekar SS, Dave JR, Desai KU, Salve PM, Sapkal NB et al (2022) Insulin-producing cell clusters derived from human gingival mesenchymal stem cells as a model for diabetes research. Mol Biol Rep 49:11973\u201311982. https:\/\/doi.org\/10.1007\/s11033-022-07979-6","journal-title":"Mol Biol Rep"},{"key":"12459_CR54","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1186\/s13287-025-04744-1","volume":"16","author":"Q Qu","year":"2025","unstructured":"Qu Q, Liu SY, Fu B, Ao Q, Long Y, Liu ZY et al (2025) Gingival mesenchymal stem cell-derived exosomal miR-23a-3p targets IL-6R to attenuate autoimmune insulitis. Stem Cell Res Ther 16:633. https:\/\/doi.org\/10.1186\/s13287-025-04744-1","journal-title":"Stem Cell Res Ther"},{"key":"12459_CR55","doi-asserted-by":"publisher","first-page":"eaar3446","DOI":"10.1126\/scitranslmed.aar3446","volume":"10","author":"X Kou","year":"2018","unstructured":"Kou X, Xu X, Chen C, Sanmillan ML, Cai T, Zhou Y et al (2018) The Fas\/Fap-1\/Cav-1 complex regulates IL-1RA secretion in mesenchymal stem cells to accelerate wound healing. Sci Transl Med 10:eaar3446. https:\/\/doi.org\/10.1126\/scitranslmed.aar3446","journal-title":"Sci Transl Med"},{"key":"12459_CR56","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/s41536-021-00170-0","volume":"6","author":"Q Zhang","year":"2021","unstructured":"Zhang Q, Nguyen P, Burrell JC, Zeng J, Shi S, Shanti RM et al (2021) Harnessing 3D collagen hydrogel-directed conversion of human GMSCs into SCP-like cells to generate functionalized nerve conduits. NPJ Regen Med 6:59. https:\/\/doi.org\/10.1038\/s41536-021-00170-0","journal-title":"NPJ Regen Med"},{"key":"12459_CR57","doi-asserted-by":"publisher","first-page":"862415","DOI":"10.3389\/fimmu.2022.862415","volume":"13","author":"Y Feng","year":"2022","unstructured":"Feng Y, Chen Z, Tu SQ, Wei JM, Hou YL, Kuang ZL et al (2022) Role of interleukin-17A in the pathomechanisms of periodontitis and related systemic chronic inflammatory diseases. Front Immunol 13:862415. https:\/\/doi.org\/10.3389\/fimmu.2022.862415","journal-title":"Front Immunol"},{"key":"12459_CR58","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s13287-018-0804-6","volume":"9","author":"R Yang","year":"2018","unstructured":"Yang R, Yu T, Liu D, Shi S, Zhou Y (2018) Hydrogen sulfide promotes immunomodulation of gingiva-derived mesenchymal stem cells via the Fas\/FasL coupling pathway. Stem Cell Res Ther 9:62. https:\/\/doi.org\/10.1186\/s13287-018-0804-6","journal-title":"Stem Cell Res Ther"},{"key":"12459_CR59","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.3390\/cells11152390","volume":"11","author":"S Nie","year":"2022","unstructured":"Nie S, Ren C, Liang X, Cai H, Sun H, Liu F et al (2022) Supramolecular hydrogel-wrapped gingival mesenchymal stem cells in cutaneous radiation injury. Cells 11:2390. https:\/\/doi.org\/10.3390\/cells11152390","journal-title":"Cells"},{"key":"12459_CR60","doi-asserted-by":"publisher","first-page":"121484","DOI":"10.1016\/j.biomaterials.2022.121484","volume":"284","author":"Z Yu","year":"2022","unstructured":"Yu Z, Wen Y, Jiang N, Li Z, Guan J, Zhang Y et al (2022) TNF-\u03b1 stimulation enhances the neuroprotective effects of gingival MSCs derived exosomes in retinal ischemia-reperfusion injury via the MEG3\/miR-21a-5p axis. Biomaterials 284:121484. https:\/\/doi.org\/10.1016\/j.biomaterials.2022.121484","journal-title":"Biomaterials"},{"key":"12459_CR61","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1186\/s13287-022-02947-2","volume":"13","author":"Q Zhang","year":"2022","unstructured":"Zhang Q, Burrell JC, Zeng J, Motiwala FI, Shi S, Cullen DK et al (2022) Implantation of a nerve protector embedded with human GMSC-derived Schwann-like cells accelerates regeneration of crush-injured rat sciatic nerves. Stem Cell Res Ther 13:263. https:\/\/doi.org\/10.1186\/s13287-022-02947-2","journal-title":"Stem Cell Res Ther"},{"key":"12459_CR62","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.jid.2019.07.722","volume":"140","author":"B Magne","year":"2020","unstructured":"Magne B, Dedier M, Nivet M, Coulomb B, Banzet S, Lataillade JJ et al (2020) IL-1\u03b2-primed mesenchymal stromal cells improve epidermal substitute engraftment and wound healing via MMPs and TGF-\u03b21. J Invest Dermatol 140:688\u2013698. https:\/\/doi.org\/10.1016\/j.jid.2019.07.722","journal-title":"J Invest Dermatol"},{"key":"12459_CR63","doi-asserted-by":"publisher","first-page":"35342","DOI":"10.1021\/acsami.1c12247","volume":"13","author":"S Pouraghaei Sevari","year":"2021","unstructured":"Pouraghaei Sevari S, Kim JK, Chen C, Nasajpour A, Wang CY, Krebsbach PH et al (2021) Whitlockite-enabled hydrogel for craniofacial bone regeneration. ACS Appl Mater Interfaces 13:35342\u201335355. https:\/\/doi.org\/10.1021\/acsami.1c12247","journal-title":"ACS Appl Mater Interfaces"},{"key":"12459_CR64","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1089\/ten.TEA.2020.0182","volume":"27","author":"U Kandalam","year":"2021","unstructured":"Kandalam U, Kawai T, Ravindran G, Brockman R, Romero J, Munro M et al (2021) Predifferentiated gingival stem cell-induced bone regeneration in rat alveolar bone defect model. Tissue Eng Part A 27:424\u2013436. https:\/\/doi.org\/10.1089\/ten.TEA.2020.0182","journal-title":"Tissue Eng Part A"},{"key":"12459_CR65","doi-asserted-by":"publisher","first-page":"3248","DOI":"10.3390\/ijms23063248","volume":"23","author":"N Sanchez","year":"2022","unstructured":"Sanchez N, Vignoletti F, Sanz-Martin I, Coca A, Nu\u00f1ez J, Maldonado E et al (2022) Cell therapy based on gingiva-derived mesenchymal stem cells seeded in a xenogeneic collagen matrix for root coverage of RT1 gingival lesions. Int J Mol Sci 23:3248. https:\/\/doi.org\/10.3390\/ijms23063248","journal-title":"Int J Mol Sci"},{"key":"12459_CR66","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1016\/j.jcyt.2022.06.004","volume":"24","author":"T Lei","year":"2022","unstructured":"Lei T, Xiao Z, Zhang X, Cai S, Bi W, Yang Y et al (2022) Human gingival mesenchymal stem cells improve movement disorders and tyrosine hydroxylase neuronal damage in Parkinson disease rats. Cytotherapy 24:1105\u20131120. https:\/\/doi.org\/10.1016\/j.jcyt.2022.06.004","journal-title":"Cytotherapy"},{"key":"12459_CR67","doi-asserted-by":"publisher","first-page":"3774","DOI":"10.1021\/acsbiomaterials.1c00646","volume":"7","author":"S Ansari","year":"2021","unstructured":"Ansari S, Pouraghaei Sevari S, Chen C, Sarrion P, Moshaverinia A (2021) RGD-modified alginate-GelMA hydrogel sheet containing gingival mesenchymal stem cells: a unique platform for wound healing and soft tissue regeneration. ACS Biomater Sci Eng 7:3774\u20133791. https:\/\/doi.org\/10.1021\/acsbiomaterials.1c00646","journal-title":"ACS Biomater Sci Eng"},{"key":"12459_CR68","doi-asserted-by":"publisher","first-page":"120558","DOI":"10.1016\/j.biomaterials.2020.120558","volume":"268","author":"A Shafiee","year":"2021","unstructured":"Shafiee A, Cavalcanti AS, Saidy NT, Schneidereit D, Friedrich O, Ravichandran A et al (2021) Convergence of 3D printed biomimetic wound dressings and adult stem cell therapy. Biomaterials 268:120558. https:\/\/doi.org\/10.1016\/j.biomaterials.2020.120558","journal-title":"Biomaterials"},{"key":"12459_CR69","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1111\/jre.12643","volume":"54","author":"KM Fawzy El-Sayed","year":"2019","unstructured":"Fawzy El-Sayed KM, Hein D, D\u00f6rfer CE (2019) Retinol\/inflammation affect stemness and differentiation potential of gingival stem\/progenitor cells via Wnt\/\u03b2-catenin. J Periodontal Res 54:413\u2013423. https:\/\/doi.org\/10.1111\/jre.12643","journal-title":"J Periodontal Res"},{"key":"12459_CR70","doi-asserted-by":"publisher","first-page":"8490","DOI":"10.3390\/app13148490","volume":"13","author":"YA Alhazmi","year":"2023","unstructured":"Alhazmi YA, Aljabri MY, Raafat SN, Alghamdi SA, Alghamdi MA, Alzahrani KM et al (2023) Exploring the effects of low-level laser therapy on the cytocompatibility and osteo\/odontogenic potential of gingival-derived mesenchymal stem cells. Appl Sci 13:8490. https:\/\/doi.org\/10.3390\/app13148490","journal-title":"Appl Sci"},{"key":"12459_CR71","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s12964-019-0412-3","volume":"17","author":"C Vidoni","year":"2019","unstructured":"Vidoni C, Ferraresi A, Secomandi E, Vallino L, Gardin C, Zavan B et al (2019) Autophagy drives osteogenic differentiation of human gingival mesenchymal stem cells. Cell Commun Signal 17:98. https:\/\/doi.org\/10.1186\/s12964-019-0412-3","journal-title":"Cell Commun Signal"},{"key":"12459_CR72","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.3390\/cells11091452","volume":"11","author":"M Mekhemar","year":"2022","unstructured":"Mekhemar M, T\u00f6lle J, Hassan Y, D\u00f6rfer CE, Fawzy El-Sayed KM (2022) Thymoquinone-mediated modulation of Toll-like receptors and pluripotency factors in gingival mesenchymal stem\/progenitor cells. Cells 11:1452. https:\/\/doi.org\/10.3390\/cells11091452","journal-title":"Cells"},{"key":"12459_CR73","doi-asserted-by":"publisher","first-page":"8450","DOI":"10.1002\/jcp.26788","volume":"233","author":"D Murugan Girija","year":"2018","unstructured":"Murugan Girija D, Kalachaveedu M, Ranga Rao S, Subbarayan R (2018) Transdifferentiation of human gingival mesenchymal stem cells into functional keratinocytes by Acalypha indica in three-dimensional microenvironment. J Cell Physiol 233:8450\u20138457. https:\/\/doi.org\/10.1002\/jcp.26788","journal-title":"J Cell Physiol"},{"key":"12459_CR74","doi-asserted-by":"publisher","DOI":"10.1101\/2023.11.03.565489","author":"MM Bahir","year":"2023","unstructured":"Bahir MM, Rajendran A, Pattanayak D, Lenka N (2023) Fabrication and characterization of ceramic-polymer composite 3D scaffolds and demonstration of osteoinductive propensity with gingival mesenchymal stem cells. bioRxiv. https:\/\/doi.org\/10.1101\/2023.11.03.565489","journal-title":"bioRxiv"},{"key":"12459_CR75","doi-asserted-by":"publisher","first-page":"100483","DOI":"10.1016\/j.mtnano.2024.100483","volume":"26","author":"Z Yu","year":"2024","unstructured":"Yu Z, Xia Y, He Y, Zhuo Y, Ge L, Wang L et al (2024) Three-dimensional dynamic culture and hypoxic preconditioning synergistically enhance the therapeutic effects of GMSCs on intracerebral hemorrhage. Mater Today Nano 26:100483. https:\/\/doi.org\/10.1016\/j.mtnano.2024.100483","journal-title":"Mater Today Nano"},{"key":"12459_CR76","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s13287-022-02787-0","volume":"13","author":"I Taihi","year":"2022","unstructured":"Taihi I, Pilon C, Cohen J, Berdal A, Gogly B, Nassif A et al (2022) Efficient isolation of human gingival stem cells in a new serum-free medium supplemented with platelet lysate and growth hormone for osteogenic differentiation enhancement. Stem Cell Res Ther 13:125. https:\/\/doi.org\/10.1186\/s13287-022-02787-0","journal-title":"Stem Cell Res Ther"},{"key":"12459_CR77","doi-asserted-by":"publisher","first-page":"3357","DOI":"10.3390\/ijms23063357","volume":"23","author":"S Cai","year":"2022","unstructured":"Cai S, Lei T, Bi W, Sun S, Deng S, Zhang X et al (2022) Chitosan hydrogel supplemented with metformin promotes neuron-like cell differentiation of gingival mesenchymal stem cells. Int J Mol Sci 23:3357. https:\/\/doi.org\/10.3390\/ijms23063357","journal-title":"Int J Mol Sci"},{"key":"12459_CR78","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.3390\/cells12121629","volume":"12","author":"J T\u00f6lle","year":"2023","unstructured":"T\u00f6lle J, Koch A, Schlicht K, Finger D, Kaehler W, H\u00f6ppner M et al (2023) Effect of hyperbaric oxygen and inflammation on human gingival mesenchymal stem\/progenitor cells. Cells 12:1629. https:\/\/doi.org\/10.3390\/cells12121629","journal-title":"Cells"},{"key":"12459_CR79","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1186\/s13287-019-1282-1","volume":"10","author":"A Shi","year":"2019","unstructured":"Shi A, Heinayati A, Bao D, Liu H, Ding X, Tong X et al (2019) Small molecule inhibitor of TGF-\u03b2 signaling enables robust osteogenesis of autologous GMSCs to successfully repair minipig severe maxillofacial bone defects. Stem Cell Res Ther 10:172. https:\/\/doi.org\/10.1186\/s13287-019-1282-1","journal-title":"Stem Cell Res Ther"},{"key":"12459_CR80","doi-asserted-by":"publisher","first-page":"1521134","DOI":"10.3389\/fbioe.2025.1521134","volume":"13","author":"G Liu","year":"2025","unstructured":"Liu G, Liu Y, Chen Y, Wan Z, Wang R, Zhang Z et al (2025) Gingival fibroblast suppress the osteogenesis process mediated by bone substitute materials via WNT\/\u03b2-catenin signaling pathway in vitro and in vivo. Front Bioeng Biotechnol 13:1521134. https:\/\/doi.org\/10.3389\/fbioe.2025.1521134","journal-title":"Front Bioeng Biotechnol"},{"key":"12459_CR81","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1089\/ten.TEA.2024.0034","volume":"30","author":"S Jiang","year":"2024","unstructured":"Jiang S, Yuan C, Zou T, Koh JH, Basabrain M, Chen Q et al (2024) An injectable hydrogel loaded with GMSCs-derived neural lineage cells promotes recovery after stroke. Tissue Eng Part A 30:563\u2013576. https:\/\/doi.org\/10.1089\/ten.TEA.2024.0034","journal-title":"Tissue Eng Part A"},{"key":"12459_CR82","doi-asserted-by":"publisher","first-page":"123769","DOI":"10.1016\/j.biomaterials.2025.123769","volume":"327","author":"B Liu","year":"2026","unstructured":"Liu B, Zhang X, Wei N, Wu X, Yuan P, Zeng T et al (2026) 3D perfusable minichannels stented with matrix bound vesicles derived from gingival mesenchymal stem cells ameliorated granuloma-related stenosis and improved survival in a rabbit tracheal replacement model. Biomaterials 327:123769. https:\/\/doi.org\/10.1016\/j.biomaterials.2025.123769","journal-title":"Biomaterials"},{"key":"12459_CR83","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1038\/s41423-023-00998-y","volume":"20","author":"P Li","year":"2023","unstructured":"Li P, Ou Q, Shi S, Shao C (2023) Immunomodulatory properties of mesenchymal stem cells\/dental stem cells and their therapeutic applications. Cell Mol Immunol 20:558\u2013569. https:\/\/doi.org\/10.1038\/s41423-023-00998-y","journal-title":"Cell Mol Immunol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12459-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12459-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12459-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:55:01Z","timestamp":1784807701000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12459-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":83,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12459"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12459-6","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,23]]},"assertion":[{"value":"23 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Ethical Statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1248"}}