{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:01:05Z","timestamp":1784901665199,"version":"3.55.0"},"reference-count":111,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12473-8","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:01:34Z","timestamp":1784898094000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advances in chrysin research for cardiovascular disorders: mechanistic insights and therapeutic prospects"],"prefix":"10.1007","volume":"53","author":[{"given":"Rudra Pratap","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7832-6858","authenticated-orcid":false,"given":"Ashutosh","family":"Solanki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"12473_CR1","doi-asserted-by":"publisher","unstructured":"Di Cesare M, McGhie DV, Perel P, Mwangi J, Taylor S, Pervan B et al (2024) The Heart of the world. Glob Heart 19(1). https:\/\/doi.org\/10.5334\/gh.1288 PubMed PMID: 38273998","DOI":"10.5334\/gh.1288"},{"key":"12473_CR2","unstructured":"Cardiovascular diseases (CVDs) [Internet]. [cited 2026 Jun 3]. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cardiovascular-diseases-(cvds)"},{"issue":"25","key":"12473_CR3","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.1016\/j.jacc.2023.11.007","volume":"82","author":"GA Mensah","year":"2023","unstructured":"Mensah GA, Fuster V, Murray CJL, Roth GA, Mensah GA, Abate YH et al (2023) Global burden of cardiovascular diseases and risks, 1990\u20132022. J Am Coll Cardiol 82(25):2350\u20132473. https:\/\/doi.org\/10.1016\/j.jacc.2023.11.007","journal-title":"J Am Coll Cardiol"},{"key":"12473_CR4","unstructured":"Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM et al (2020) Global burden of cardiovascular diseases and risk factors, 1990\u20132019: Update from the GBD 2019 Study. Journal of the american college of cardiology. Elsevier Inc., pp 2982\u20133021. .010 PubMed PMID: 33309175"},{"key":"12473_CR5","doi-asserted-by":"publisher","unstructured":"Qiu Y, Zhao P, Xu L, Zeng J, Wu D, Yang R et al (2025) Therapeutic mechanisms of Acorus tatarinowii and its bioactive compounds in cardiovascular diseases: A comprehensive review. Phytomedicine 145. https:\/\/doi.org\/10.1016\/j.phymed.2025.156988 PubMed PMID: 40578036","DOI":"10.1016\/j.phymed.2025.156988"},{"key":"12473_CR6","doi-asserted-by":"publisher","unstructured":"Zhang W, Zheng Y, Yan F, Dong M, Ren Y (2023) Research progress of quercetin in cardiovascular disease. Front Cardiovasc Med 10. https:\/\/doi.org\/10.3389\/fcvm.2023.1203713","DOI":"10.3389\/fcvm.2023.1203713"},{"key":"12473_CR7","doi-asserted-by":"publisher","unstructured":"Liu Xyu, Nie Y ke, Liu Y, Chen M (2025) Cardiovascular protective properties of the natural product eugenol. Eur J Pharmacol. ;1003:177929. https:\/\/doi.org\/10.1016\/j.ejphar.2025.177929","DOI":"10.1016\/j.ejphar.2025.177929"},{"key":"12473_CR8","doi-asserted-by":"publisher","first-page":"173535","DOI":"10.1016\/j.ejphar.2020.173535","volume":"887","author":"R Heidary Moghaddam","year":"2020","unstructured":"Heidary Moghaddam R, Samimi Z, Moradi SZ, Little PJ, Xu S, Farzaei MH (2020) Naringenin and naringin in cardiovascular disease prevention: A preclinical review. Eur J Pharmacol 887:173535. https:\/\/doi.org\/10.1016\/j.ejphar.2020.173535","journal-title":"Eur J Pharmacol"},{"key":"12473_CR9","doi-asserted-by":"publisher","unstructured":"Zhang J, Chen Y, Zhong Y, Wang Y, Huang H, Xu W et al (2025) Intermittent fasting and cardiovascular health: a circadian rhythm-based approach. Sci Bull Elsevier B 2377\u20132389. https:\/\/doi.org\/10.1016\/j.scib.2025.05.017","DOI":"10.1016\/j.scib.2025.05.017"},{"key":"12473_CR10","doi-asserted-by":"publisher","unstructured":"Hou C, Zheng Z, Zheng X, Liu M, Xu S, Chen R et al (2026 Mar) The nonlinear relationship between serum uric acid and cardiovascular disease risk: Mechanistic insights and clinical implications. Cardiovasc Drugs Ther 16. https:\/\/doi.org\/10.1007\/s10557-026-07866-7","DOI":"10.1007\/s10557-026-07866-7"},{"issue":"21","key":"12473_CR11","doi-asserted-by":"publisher","first-page":"6456","DOI":"10.3390\/molecules26216456","volume":"26","author":"A Mishra","year":"2021","unstructured":"Mishra A, Mishra PS, Bandopadhyay R, Khurana N, Angelopoulou E, Paudel YN et al (2021) Neuroprotective potential of chrysin: Mechanistic insights and therapeutic potential for neurological disorders. Molecules 26(21):6456. https:\/\/doi.org\/10.3390\/molecules26216456","journal-title":"Molecules"},{"key":"12473_CR12","doi-asserted-by":"publisher","first-page":"104612","DOI":"10.1016\/j.neuint.2019.104612","volume":"132","author":"E Angelopoulou","year":"2020","unstructured":"Angelopoulou E, Pyrgelis ES, Piperi C (2020) Neuroprotective potential of chrysin in Parkinson\u2019s disease: Molecular mechanisms and clinical implications. Neurochem Int 132:104612. https:\/\/doi.org\/10.1016\/j.neuint.2019.104612","journal-title":"Neurochem Int"},{"key":"12473_CR13","doi-asserted-by":"publisher","unstructured":"Nabavi SF, Braidy N, Habtemariam S, Orhan IE, Daglia M, Manayi A et al (2015) Neuroprotective effects of chrysin: From chemistry to medicine. Neurochemistry International. Elsevier Ltd, pp 224\u2013231. https:\/\/doi.org\/10.1016\/j.neuint2015.09.006 PubMed PMID: 26386393","DOI":"10.1016\/j.neuint"},{"key":"12473_CR14","doi-asserted-by":"publisher","unstructured":"Naz S, Imran M, Rauf A, Orhan IE, Shariati MA, Iahtisham-Ul-Haq et al (2019) Chrysin: Pharmacological and therapeutic properties. Life Sciences. Elsevier Inc. https:\/\/doi.org\/10.1016\/j.lfs.2019.116797 PubMed PMID: 31472146","DOI":"10.1016\/j.lfs.2019.116797"},{"key":"12473_CR15","doi-asserted-by":"publisher","unstructured":"Kurkiewicz M, Mo\u017adzierz A, Rzepecka-Stojko A, Stojko J, Chrysin (2025) A comprehensive review of its pharmacological properties and therapeutic potential. Pharmaceuticals. Multidisciplinary Digital Publishing Institute (MDPI). https:\/\/doi.org\/10.3390\/ph18081162","DOI":"10.3390\/ph18081162"},{"issue":"7","key":"12473_CR16","doi-asserted-by":"publisher","first-page":"555","DOI":"10.2174\/1389557518666180424094821","volume":"19","author":"Y Li","year":"2019","unstructured":"Li Y, Li Ypeng, He J, Liu D, Zhang Qzhi, Li K et al (2019) The relationship between pharmacological properties and structure- activity of chrysin derivatives. Mini-Reviews Med Chem 19(7):555\u2013568. https:\/\/doi.org\/10.2174\/1389557518666180424094821","journal-title":"Mini-Reviews Med Chem"},{"key":"12473_CR17","doi-asserted-by":"publisher","unstructured":"Mani R, Natesan V, Chrysin (2018) Sources, beneficial pharmacological activities, and molecular mechanism of action. Phytochemistry. Elsevier Ltd, pp 187\u2013196. https:\/\/doi.org\/10.1016\/j.phytochem.2017.09.016 PubMed PMID: 29161583","DOI":"10.1016\/j.phytochem.2017.09"},{"key":"12473_CR18","doi-asserted-by":"publisher","unstructured":"Mohos V, Flisz\u00e1r-Ny\u00fal E, Schilli G, Het\u00e9nyi C, Lemli B, Kuns\u00e1gi-M\u00e1t\u00e9 S et al (2018) Interaction of chrysin and its main conjugated metabolites chrysin-7-sulfate and chrysin-7-glucuronide with serum albumin. Int J Mol Sci 19(12). https:\/\/doi.org\/10.3390\/ijms19124073 PubMed PMID: 30562928","DOI":"10.3390\/ijms19124073"},{"issue":"4","key":"12473_CR19","doi-asserted-by":"publisher","first-page":"420","DOI":"10.2174\/1389450122666210824141044","volume":"23","author":"A Garg","year":"2021","unstructured":"Garg A, Chaturvedi S (2021) A comprehensive review on Chrysin: Emphasis on molecular targets, pharmacological actions and bio-pharmaceutical aspects. Curr Drug Targets 23(4):420\u2013436 doi:10.2174\/1389450122666210824141044 PubMed PMID: 34431464","journal-title":"Curr Drug Targets"},{"key":"12473_CR20","doi-asserted-by":"publisher","unstructured":"Gezici S, Sekeroglu N (2023) Bioinformatics approach to identify molecular targets of chrysin against Alzheimer\u2019s disease. Annals Phytomedicine Int J 12(1). https:\/\/doi.org\/10.54085\/ap.2023.12.1.38","DOI":"10.54085\/ap.2023.12.1.38"},{"key":"12473_CR21","doi-asserted-by":"publisher","unstructured":"Pitchakarn P, Ting P, Buacheen P, Karinchai J, Inthachat W, Chantong B et al (2024) Multi-endpoint toxicological assessment of chrysin loaded oil-in-water emulsion system in different biological models. Nanomaterials 14(12). https:\/\/doi.org\/10.3390\/nano14121001","DOI":"10.3390\/nano14121001"},{"key":"12473_CR22","doi-asserted-by":"publisher","unstructured":"Adesina AF, Adewuyi A, Otuechere CA (2024) Exploratory studies on chrysin via antioxidant, antimicrobial, ADMET, PASS and molecular docking evaluations. Pharmacol Res - Mod Chin Med 11. https:\/\/doi.org\/10.1016\/j.prmcm.2024.100413","DOI":"10.1016\/j.prmcm.2024.100413"},{"key":"12473_CR23","doi-asserted-by":"publisher","unstructured":"Gao S, Siddiqui N, Etim I, Du T, Zhang Y, Liang D (2021) Developing nutritional component chrysin as a therapeutic agent: Bioavailability and pharmacokinetics consideration, and ADME mechanisms. Biomedicine and Pharmacotherapy. https:\/\/doi.org\/10.1016\/j.biopha.2021.112080. PubMed PMID: 34449320 Elsevier Masson s.r.l.","DOI":"10.1016\/j.biopha.2021.112080"},{"key":"12473_CR24","doi-asserted-by":"publisher","unstructured":"Dabiri S, Jafari S, Molavi O (2024) Advances in nanocarrier-mediated delivery of chrysin: Enhancing solubility, bioavailability, and anticancer efficacy. BioImpacts. 9. https:\/\/doi.org\/10.34172\/bi.30269","DOI":"10.34172\/bi.30269"},{"issue":"4","key":"12473_CR25","doi-asserted-by":"publisher","first-page":"420","DOI":"10.2174\/1389450122666210824141044","volume":"23","author":"A Garg","year":"2022","unstructured":"Garg A, Chaturvedi S (2022) A Comprehensive Review on Chrysin: Emphasis on Molecular Targets, Pharmacological Actions and Bio-pharmaceutical Aspects. Curr Drug Targets 23(4):420\u2013436. https:\/\/doi.org\/10.2174\/1389450122666210824141044","journal-title":"Curr Drug Targets"},{"issue":"3","key":"12473_CR26","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1208\/s12249-024-02767-0","volume":"25","author":"SM Elhoseny","year":"2024","unstructured":"Elhoseny SM, Saleh NM, Meshali MM (2024) Self-Nanoemulsion Intrigues the Gold Phytopharmaceutical Chrysin: In Vitro Assessment and Intrinsic Analgesic Effect. AAPS PharmSciTech 25(3):54. https:\/\/doi.org\/10.1208\/s12249-024-02767-0","journal-title":"AAPS PharmSciTech"},{"issue":"7","key":"12473_CR27","doi-asserted-by":"publisher","first-page":"2719","DOI":"10.1007\/s11010-021-04105-5","volume":"476","author":"S Yuvaraj","year":"2021","unstructured":"Yuvaraj S, Ramprasath T, Saravanan B, Vasudevan V, Sasikumar S, Selvam GS (2021) Chrysin attenuates high-fat-diet-induced myocardial oxidative stress via upregulating eNOS and Nrf2 target genes in rats. Mol Cell Biochem 476(7):2719\u20132727. https:\/\/doi.org\/10.1007\/s11010-021-04105-5 PubMed PMID: 33677805","journal-title":"Mol Cell Biochem"},{"key":"12473_CR28","doi-asserted-by":"publisher","unstructured":"Daiber A, Chlopicki S (2020) Revisiting pharmacology of oxidative stress and endothelial dysfunction in cardiovascular disease: Evidence for redox-based therapies. Free Radical Biology and Medicine. Elsevier Inc., pp 15\u201337. doi: https:\/\/doi.org\/10.1016\/j.freeradbiomed.2020.02.026 PubMed PMID: 32131026","DOI":"10.1016\/j.freeradbiomed.2020.02.026"},{"key":"12473_CR29","doi-asserted-by":"publisher","unstructured":"Sharata EE, Attya ME, Khalaf MM, Rofaeil RR, Hemeida RAM, Abo-Youssef AM (2025) Unraveling chemotherapy-evoked hepatic dysfunction: a deep dive into cyclophosphamide-related liver injury. Naunyn-Schmiedeberg\u2019s Archives of Pharmacology. Springer Science and Business Media Deutschland GmbH. https:\/\/doi.org\/10.1007\/s00210-025-04583-0","DOI":"10.1007\/s00210-025-04583-0"},{"key":"12473_CR30","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.ejmech.2017.07.034","volume":"142","author":"D Raffa","year":"2017","unstructured":"Raffa D, Maggio B, Raimondi MV, Plescia F, Daidone G (2017) Recent discoveries of anticancer flavonoids. Eur J Med Chem 142:213\u2013228. https:\/\/doi.org\/10.1016\/j.ejmech.2017.07.034","journal-title":"Eur J Med Chem"},{"key":"12473_CR31","doi-asserted-by":"publisher","unstructured":"Roy R, Wilcox J, Webb AJ, O\u2019Gallagher K (2023) Dysfunctional and Dysregulated Nitric Oxide Synthases in Cardiovascular Disease: Mechanisms and Therapeutic Potential. International Journal of Molecular Sciences. Multidisciplinary Digital Publishing Institute (MDPI); https:\/\/doi.org\/10.3390\/ijms242015200 PubMed PMID: 37894881","DOI":"10.3390\/ijms242015200"},{"key":"12473_CR32","doi-asserted-by":"publisher","unstructured":"Teuber JP, Essandoh K, Hummel SL, Madamanchi NR, Brody MJ (2022) NADPH Oxidases in Diastolic Dysfunction and Heart Failure with Preserved Ejection Fraction. Antioxidants. MDPI. https:\/\/doi.org\/10.3390\/antiox11091822","DOI":"10.3390\/antiox11091822"},{"issue":"6","key":"12473_CR33","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1124\/pharmrev.124.001060","volume":"76","author":"M Carlstr\u00f6m","year":"2024","unstructured":"Carlstr\u00f6m M, Weitzberg E, Lundberg JO (2024) Nitric Oxide Signaling and Regulation in the Cardiovascular System: Recent Advances. Pharmacol Rev 76(6):1038\u20131062. https:\/\/doi.org\/10.1124\/pharmrev.124.001060","journal-title":"Pharmacol Rev"},{"key":"12473_CR34","doi-asserted-by":"publisher","unstructured":"Jin M, Fang J, Wang Jjiao, Shao X, Xu S, wen, Liu Pqing et al (2023) Regulation of toll-like receptor (TLR) signaling pathways in atherosclerosis: from mechanisms to targeted therapeutics. Acta Pharmacologica Sinica. Springer Nature, pp 2358\u20132375. https:\/\/doi.org\/10.1038\/s41401-023-01123-5 PubMed PMID: 37550526","DOI":"10.1038\/s41401-023-01123-5"},{"key":"12473_CR35","doi-asserted-by":"publisher","unstructured":"Thangasparan S, Kamisah Y, Ugusman A, Mohamad Anuar NN, Ibrahim N (2024) Izzah. Unravelling the Mechanisms of Oxidised Low-Density Lipoprotein in Cardiovascular Health: Current Evidence from In Vitro and. Vivo Studies. International Journal of Molecular Sciences. Multidisciplinary Digital Publishing Institute (MDPI). doi:https:\/\/doi.org\/10.3390\/ijms252413292. PubMed PMID: 39769058","DOI":"10.3390\/ijms252413292"},{"key":"12473_CR36","doi-asserted-by":"publisher","first-page":"115719","DOI":"10.1016\/j.fct.2025.115719","volume":"205","author":"EE Sharata","year":"2025","unstructured":"Sharata EE, Attya ME, Khalaf MM, Rofaeil RR, Abo-Youssef AM, Hemeida RAM (2025) Decoding premature ovarian insufficiency: A full spectrum review from epidemiology to management with emphasis on cyclophosphamide-evoked ovarian injury. Food Chem Toxicol 205:115719. https:\/\/doi.org\/10.1016\/j.fct.2025.115719","journal-title":"Food Chem Toxicol"},{"issue":"5","key":"12473_CR37","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1111\/jphp.12032","volume":"65","author":"L Testai","year":"2013","unstructured":"Testai L, Martelli A, Cristofaro M, Breschi MC, Calderone V (2013) Cardioprotective effects of different flavonoids against myocardial ischaemia\/reperfusion injury in Langendorff-perfused rat hearts. J Pharm Pharmacol 65(5):750\u2013756. https:\/\/doi.org\/10.1111\/jphp.12032 PubMed PMID: 23600393","journal-title":"J Pharm Pharmacol"},{"key":"12473_CR38","doi-asserted-by":"publisher","unstructured":"Yang B, Hang S, Xu S, Gao Y, Yu W, Zang G et al (2024) Macrophage polarisation and inflammatory mechanisms in atherosclerosis: Implications for prevention and treatment. Heliyon. Elsevier Ltd. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e32073","DOI":"10.1016\/j.heliyon.2024.e32073"},{"issue":"1","key":"12473_CR39","doi-asserted-by":"publisher","first-page":"13","DOI":"10.14302\/issn.2641-7669.ject-17-1789","volume":"1","author":"OME Abdel-Salam","year":"2017","unstructured":"Abdel-Salam OME, Shaffie NM, Mohammed NA, Youness ER, Morsy SMY, Sleem AA (2017) The 5-HT1A Agonist Buspirone Decreases Liver Oxidative Stress and Exerts Protective Effect Against CCl4\u2013 Toxicity. J Experimental Clin Toxicol 1(1):13\u201326. https:\/\/doi.org\/10.14302\/issn.2641-7669.ject-17-1789","journal-title":"J Experimental Clin Toxicol"},{"key":"12473_CR40","doi-asserted-by":"publisher","unstructured":"Li A, Zheng N, Ding X (2022) Mitochondrial abnormalities: a hub in metabolic syndrome-related cardiac dysfunction caused by oxidative stress. Heart Failure Reviews. Springer; pp. 1387\u201394. https:\/\/doi.org\/10.1007\/s10741-021-10109-6 PubMed PMID: 33950478","DOI":"10.1007\/s10741-021-10109-6"},{"issue":"6","key":"12473_CR41","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1080\/10799893.2020.1772297","volume":"40","author":"N Zheng","year":"2020","unstructured":"Zheng N, Li H, Wang X, Zhao Z, Shan D (2020) Oxidative stress-induced cardiomyocyte apoptosis is associated with dysregulated Akt\/p53 signaling pathway. J Recept Signal Transduction 40(6):599\u2013604. https:\/\/doi.org\/10.1080\/10799893.2020.1772297 PubMed PMID: 32460597","journal-title":"J Recept Signal Transduction"},{"key":"12473_CR42","doi-asserted-by":"crossref","unstructured":"Shah GB, Prajapati AKK. The role of TGF-\u03b2 in cardiac fibrosis and heart failure:A review. IP International Journal of Comprehensive and Advanced Pharmacology. 2024;9(1):1\u20136.doi:10.18231\/j.ijcaap.2024.001","DOI":"10.18231\/j.ijcaap.2024.001"},{"key":"12473_CR43","doi-asserted-by":"publisher","unstructured":"Kremastiotis G, Handa I, Jackson C, George S, Johnson J (2021) Disparate effects of MMP and TIMP modulation on coronary atherosclerosis and associated myocardial fibrosis. Sci Rep 11(1). https:\/\/doi.org\/10.1038\/s41598-021-02508-4 PubMed PMID: 34848763","DOI":"10.1038\/s41598-021-02508-4"},{"key":"12473_CR44","doi-asserted-by":"publisher","unstructured":"Yang P, Feng J, Peng Q, Liu X, Fan Z, Luca M (2019) Advanced Glycation End Products: Potential Mechanism and Therapeutic Target in Cardiovascular Complications under Diabetes. Oxidative Medicine and Cellular Longevity. Hindawi Limited. https:\/\/doi.org\/10.1155\/2019\/9570616 PubMed PMID: 31885827","DOI":"10.1155\/2019\/9570616"},{"key":"12473_CR45","doi-asserted-by":"publisher","unstructured":"Sebastian SA, Padda I, Johal G (2024) Cardiovascular-Kidney-Metabolic (CKM) syndrome: A state-of-the-art review. Current Problems in Cardiology. Elsevier Inc. doi:https:\/\/doi.org\/10.1016\/j.cpcardiol.2023.102344. PubMed PMID: 38103820","DOI":"10.1016\/j.cpcardiol.2023.102344"},{"key":"12473_CR46","doi-asserted-by":"publisher","unstructured":"Saleh M, Ambrose JA (2018) Understanding myocardial infarction. F1000Research. F1000 Research Ltd. https:\/\/doi.org\/10.12688\/f1000research.15096.1. PubMed PMID: 30228871","DOI":"10.12688\/f1000research.15096.1"},{"key":"12473_CR47","doi-asserted-by":"publisher","unstructured":"Chuang AMY, Nguyen MT, Khan E, Jones D, Horsfall M, Lehman S et al (2021) Troponin elevation pattern and subsequent cardiac and non-cardiac outcomes: Implementing the Fourth Universal Definition of Myocardial Infarction and high-sensitivity troponin at a population level. PLoS ONE 16(3 March). https:\/\/doi.org\/10.1371\/journal.pone.0248289 PubMed PMID: 33711079","DOI":"10.1371\/journal.pone.0248289"},{"key":"12473_CR48","doi-asserted-by":"crossref","unstructured":"Kim SJ, Mesquita FCP, Hochman-Mendez C (2023) New Biomarkers for Cardiovascular Disease. Tex Heart Inst J Tex Heart Inst. 10.14503\/THIJ-23-8178 PubMed PMID: 37846107","DOI":"10.14503\/THIJ-23-8178"},{"issue":"1","key":"12473_CR49","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1136\/heartjnl-2016-309530","volume":"103","author":"AR Chapman","year":"2017","unstructured":"Chapman AR, Adamson PD, Mills NL (2017) Assessment and classification of patients with myocardial injury and infarction in clinical practice. Heart 103(1):10\u201318. https:\/\/doi.org\/10.1136\/heartjnl-2016-309530 PubMed PMID: 27806987","journal-title":"Heart"},{"key":"12473_CR50","unstructured":"Gowraganahalli J, Pitchai B, Khin MU Pathophysiology and Pharmacotherapy of Cardiovascular Disease"},{"key":"12473_CR51","doi-asserted-by":"publisher","unstructured":"Costa D, Ielapi N, Perri P, Minici R, Faga T, Michael A et al (2024) Molecular Insight into Acute Limb Ischemia. Biomolecules. Multidisciplinary Digital Publishing Institute (MDPI). https:\/\/doi.org\/10.3390\/biom14070838 PubMed PMID: 39062551","DOI":"10.3390\/biom14070838"},{"key":"12473_CR52","doi-asserted-by":"publisher","unstructured":"Wang X, Chen L, Wei J, Zheng H, Zhou N, Xu X et al (2025) The immune system in cardiovascular diseases: from basic mechanisms to therapeutic implications. Signal Transduction and Targeted Therapy. Springer Nature. https:\/\/doi.org\/10.1038\/s41392-025-02220-z PubMed PMID: 40404619","DOI":"10.1038\/s41392-025-02220-z"},{"key":"12473_CR53","doi-asserted-by":"publisher","unstructured":"Chen R, Zhang H, Tang B, Luo Y, Yang Y, Zhong X et al (2024) Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets. Signal Transduction and Targeted Therapy. Springer Nature. https:\/\/doi.org\/10.1038\/s41392-024-01840-1 PubMed PMID: 38816371","DOI":"10.1038\/s41392-024-01840-1"},{"key":"12473_CR54","doi-asserted-by":"publisher","unstructured":"Rani N, Arya DS (2020) Chrysin rescues rat myocardium from ischemia-reperfusion injury via PPAR-\u03b3\/Nrf2 activation. Eur J Pharmacol 883. https:\/\/doi.org\/10.1016\/j.ejphar.2020.173389 PubMed PMID: 32707190","DOI":"10.1016\/j.ejphar.2020.173389"},{"key":"12473_CR55","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.cbi.2016.03.015","volume":"250","author":"N Rani","year":"2016","unstructured":"Rani N, Bharti S, Bhatia J, Nag TC, Ray R, Arya DS (2016) Chrysin, a PPAR-\u03b3 agonist improves myocardial injury in diabetic rats through inhibiting AGE-RAGE mediated oxidative stress and inflammation. Chem Biol Interact 250:59\u201367. https:\/\/doi.org\/10.1016\/j.cbi.2016.03.015 PubMed PMID: 26972669","journal-title":"Chem Biol Interact"},{"issue":"6","key":"12473_CR56","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/s10735-018-9793-0","volume":"49","author":"M Yang","year":"2018","unstructured":"Yang M, Xiong J, Zou Q, Wang DD, Huang CX (2018) Chrysin attenuates interstitial fibrosis and improves cardiac function in a rat model of acute myocardial infarction. J Mol Histol 49(6):555\u2013565. https:\/\/doi.org\/10.1007\/s10735-018-9793-0 PubMed PMID: 30225683","journal-title":"J Mol Histol"},{"key":"12473_CR57","doi-asserted-by":"publisher","first-page":"155535","DOI":"10.1016\/j.phymed.2024.155535","volume":"128","author":"Jjing Zhang","year":"2024","unstructured":"Zhang Jjing, Mao-mao, Shao M, min, Wang Mchuan (2024) Therapeutic potential of natural flavonoids in pulmonary arterial hypertension: A review. Phytomedicine 128:155535. https:\/\/doi.org\/10.1016\/j.phymed.2024.155535","journal-title":"Phytomedicine"},{"key":"12473_CR58","doi-asserted-by":"publisher","unstructured":"Johnson S, Sommer N, Cox-Flaherty K, Weissmann N, Ventetuolo CE, Maron BA (2023) Pulmonary Hypertension: A Contemporary Review. American Journal of Respiratory and Critical Care Medicine. American Thoracic Society, pp 528\u2013548. https:\/\/doi.org\/10.1164\/rccm.202302-0327SO PubMed PMID: 37450768","DOI":"10.1164\/rccm.202302-0327SO"},{"key":"12473_CR59","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01324-2024","author":"G Kovacs","year":"2024","unstructured":"Kovacs G, Bartolome S, Denton CP, Gatzoulis MA, Gu S, Khanna D et al (2024) Definition, classification and diagnosis of pulmonary hypertension. Eur Respiratory J Eur Respiratory Soc. https:\/\/doi.org\/10.1183\/13993003.01324-2024 PubMed PMID: 39209475","journal-title":"Eur Respiratory J Eur Respiratory Soc"},{"issue":"1","key":"12473_CR60","doi-asserted-by":"publisher","first-page":"210","DOI":"10.3390\/ijms27010210","volume":"27","author":"X Zhang","year":"2025","unstructured":"Zhang X, Chen M, Wang R, Liu R, Gong D, Zhang M et al (2025) Flavonoids: Potential New Drug Candidates for Attenuating Vascular Remodeling in Pulmonary Hypertension. Int J Mol Sci 27(1):210. https:\/\/doi.org\/10.3390\/ijms27010210","journal-title":"Int J Mol Sci"},{"issue":"1","key":"12473_CR61","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1161\/CIRCRESAHA.113.301141","volume":"115","author":"M Rabinovitch","year":"2014","unstructured":"Rabinovitch M, Guignabert C, Humbert M, Nicolls MR (2014) Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension. Circ Res 115(1):165\u2013175. https:\/\/doi.org\/10.1161\/CIRCRESAHA.113.301141","journal-title":"Circ Res"},{"key":"12473_CR62","doi-asserted-by":"publisher","unstructured":"Mocumbi A, Humbert M, Saxena A, Jing ZC, Sliwa K, Thienemann F et al (2024) Pulmonary hypertension. Nat Rev Dis Primers 10(1). https:\/\/doi.org\/10.1038\/s41572-023-00486-7 PubMed PMID: 38177157","DOI":"10.1038\/s41572-023-00486-7"},{"key":"12473_CR63","doi-asserted-by":"publisher","DOI":"10.1136\/bmjmed-2022-000137","author":"S Bousseau","year":"2023","unstructured":"Bousseau S, Sobrano Fais R, Gu S, Frump A, Lahm T (2023) Pathophysiology and new advances in pulmonary hypertension. BMJ Med BMJ Publishing Group. https:\/\/doi.org\/10.1136\/bmjmed-2022-000137 PubMed PMID: 37051026","journal-title":"BMJ Med BMJ Publishing Group"},{"key":"12473_CR64","doi-asserted-by":"crossref","unstructured":"Dong F, Zhang J, Chen X, Zhang S, Zhu L, Peng Y et al (2020) Chrysin Alleviates Monocrotaline-Induced Pulmonary Hypertension in Rats Through Regulation of Intracellular Calcium Homeostasis in Pulmonary Arterial Smooth Muscle Cells [Internet]. Available from: http:\/\/journals.lww.com\/cardiovascularpharm","DOI":"10.1097\/FJC.0000000000000823"},{"issue":"5","key":"12473_CR65","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1097\/FJC.0000000000000726","volume":"74","author":"F Dong","year":"2019","unstructured":"Dong F, Zhang J, Zhu S, Lan T, Yang J, Li L (2019) Chrysin alleviates chronic hypoxia\u2013induced pulmonary hypertension by reducing intracellular calcium concentration in pulmonary arterial smooth muscle cells. J Cardiovasc Pharmacol 74(5):426\u2013435. https:\/\/doi.org\/10.1097\/FJC.0000000000000726","journal-title":"J Cardiovasc Pharmacol"},{"key":"12473_CR66","doi-asserted-by":"publisher","unstructured":"Kobayashi T, Kim JD, Naito A, Yanagisawa A, Jujo-Sanada T, Kasuya Y et al (2022) Multi-omics analysis of right ventricles in rat models of pulmonary arterial hypertension: Consideration of mitochondrial biogenesis by chrysin. Int J Mol Med 49(5). https:\/\/doi.org\/10.3892\/ijmm.2022.5124 PubMed PMID: 35315498","DOI":"10.3892\/ijmm.2022.5124"},{"key":"12473_CR67","doi-asserted-by":"publisher","unstructured":"Li XW, Wang XM, Li S, Yang JR (2015) Effects of chrysin (5,7-dihydroxyflavone) on vascular remodeling in hypoxia-induced pulmonary hypertension in rats. Chin Med (United Kingdom) 10(1). https:\/\/doi.org\/10.1186\/s13020-015-0032-2","DOI":"10.1186\/s13020-015-0032-2"},{"issue":"3","key":"12473_CR68","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/pin.13202","volume":"72","author":"J Fan","year":"2022","unstructured":"Fan J, Watanabe T, Atherosclerosis (2022) Known and unknown. Pathol Int 72(3):151\u2013160. https:\/\/doi.org\/10.1111\/pin.13202","journal-title":"Pathol Int"},{"key":"12473_CR69","doi-asserted-by":"publisher","unstructured":"Meng T, Li X, Li C, Liu J, Chang H, Jiang N et al (2022) Natural products of traditional Chinese medicine treat atherosclerosis by regulating inflammatory and oxidative stress pathways. Front Pharmacol 13. https:\/\/doi.org\/10.3389\/fphar.2022.997598","DOI":"10.3389\/fphar.2022.997598"},{"issue":"12","key":"12473_CR70","doi-asserted-by":"publisher","first-page":"e32563","DOI":"10.1016\/j.heliyon.2024.e32563","volume":"10","author":"Y Liu","year":"2024","unstructured":"Liu Y, Luo J, Peng L, Zhang Q, Rong X, Luo Y et al (2024) Flavonoids: Potential therapeutic agents for cardiovascular disease. Heliyon 10(12):e32563. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e32563","journal-title":"Heliyon"},{"issue":"11","key":"12473_CR71","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/s41419-024-07166-8","volume":"15","author":"A Ajoolabady","year":"2024","unstructured":"Ajoolabady A, Pratico D, Lin L, Mantzoros CS, Bahijri S, Tuomilehto J et al (2024) Inflammation in atherosclerosis: pathophysiology and mechanisms. Cell Death Dis 15(11):817. https:\/\/doi.org\/10.1038\/s41419-024-07166-8","journal-title":"Cell Death Dis"},{"issue":"4","key":"12473_CR72","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1161\/CIRCRESAHA.115.306301","volume":"118","author":"MA Gimbrone","year":"2016","unstructured":"Gimbrone MA, Garc\u00eda-Carde\u00f1a G (2016) Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis. Circ Res 118(4):620\u2013636. https:\/\/doi.org\/10.1161\/CIRCRESAHA.115.306301","journal-title":"Circ Res"},{"issue":"1\u20132","key":"12473_CR73","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s11010-013","volume":"385","author":"R Anandhi","year":"2014","unstructured":"Anandhi R, Thomas PA, Geraldine P (2014) Evaluation of the anti-atherogenic potential of chrysin in Wistar rats. Mol Cell Biochem 385(1\u20132):103\u2013113. https:\/\/doi.org\/10.1007\/s11010-013-1819-z PubMed PMID: 24065391","journal-title":"Mol Cell Biochem"},{"issue":"8","key":"12473_CR74","doi-asserted-by":"publisher","first-page":"4345","DOI":"10.1007\/s00394-021-02593-1","volume":"60","author":"CM Lin","year":"2021","unstructured":"Lin CM, Wang BW, Pan CM, Fang WJ, Chua SK, Cheng WP et al (2021) Chrysin boosts KLF2 expression through suppression of endothelial cell-derived exosomal microRNA-92a in the model of atheroprotection. Eur J Nutr 60(8):4345\u20134355. https:\/\/doi.org\/10.1007\/s00394-021-02593-1 PubMed PMID: 34041583","journal-title":"Eur J Nutr"},{"issue":"2","key":"12473_CR75","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/cjoc.202200406","volume":"41","author":"L Chen","year":"2023","unstructured":"Chen L, Jiang Z, Yang L, Fang Y, Lu S, Akakuru OU et al (2023) HPDA\/Zn as a CREB Inhibitor for Ultrasound Imaging and Stabilization of Atherosclerosis Plaque\u2020. Chin J Chem 41(2):199\u2013206. https:\/\/doi.org\/10.1002\/cjoc.202200406","journal-title":"Chin J Chem"},{"issue":"10","key":"12473_CR76","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1038\/s41401-024-01305-9","volume":"45","author":"WZ Wang","year":"2024","unstructured":"Wang WZ, Liu C, Luo JQ, Lei LJ, Chen MH, Zhang YY et al (2024) A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis. Acta Pharmacol Sin 45(10):2119\u20132133. https:\/\/doi.org\/10.1038\/s41401-024-01305-9 PubMed PMID: 38811775","journal-title":"Acta Pharmacol Sin"},{"key":"12473_CR77","doi-asserted-by":"publisher","unstructured":"Csonka C, S\u00e1rk\u00f6zy M, Pipicz M, Dux L, Csont T (2016) Modulation of Hypercholesterolemia-Induced Oxidative\/Nitrative Stress in the Heart. Oxid Med Cell Longev 2016(1). https:\/\/doi.org\/10.1155\/2016\/3863726","DOI":"10.1155\/2016\/3863726"},{"issue":"4","key":"12473_CR78","doi-asserted-by":"publisher","first-page":"822","DOI":"10.17305\/bb.2024.10764","volume":"25","author":"G Vargas-Alarc\u00f3n","year":"2025","unstructured":"Vargas-Alarc\u00f3n G, Posadas-S\u00e1nchez R, P\u00e9rez-M\u00e9ndez O, Fragoso JM (2025) Cholesterol 7 alpha-hydroxylase (CYP7A1) gene polymorphisms are associated with increased LDL-cholesterol levels and the incidence of subclinical atherosclerosis. Biomolecules Biomed 25(4):822\u2013832. https:\/\/doi.org\/10.17305\/bb.2024.10764 PubMed PMID: 39207177","journal-title":"Biomolecules Biomed"},{"issue":"6","key":"12473_CR79","doi-asserted-by":"publisher","first-page":"564","DOI":"10.62225\/2583049x.2024.4.6.3475","volume":"4","author":"CE Rabad\u00e1n-Mart\u00ednez","year":"2024","unstructured":"Rabad\u00e1n-Mart\u00ednez CE, Mart\u00ednez-Hern\u00e1ndez Y, Cruz-Cortes I, Rosas-Paz NE, Montero-Toledo E, Hern\u00e1ndez-Osorio LA et al (2024) Pathogenesis of the Hypercholesterolemia and the Role in Public Health. Int J Adv Multidisciplinary Res Stud 4(6):564\u2013567. https:\/\/doi.org\/10.62225\/2583049x.2024.4.6.3475","journal-title":"Int J Adv Multidisciplinary Res Stud"},{"issue":"2","key":"12473_CR80","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s13105-012-0215-6","volume":"69","author":"R Anandhi","year":"2013","unstructured":"Anandhi R, Annadurai T, Anitha TS, Muralidharan AR, Najmunnisha K, Nachiappan V et al (2013) Antihypercholesterolemic and antioxidative effects of an extract of the oyster mushroom, Pleurotus ostreatus, and its major constituent, chrysin, in Triton WR-1339-induced hypercholesterolemic rats. J Physiol Biochem 69(2):313\u2013323. https:\/\/doi.org\/10.1007\/s13105-012-0215-6","journal-title":"J Physiol Biochem"},{"issue":"7","key":"12473_CR81","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1007\/s00210-021-02072-8","volume":"394","author":"F Yarmohammadi","year":"2021","unstructured":"Yarmohammadi F, Hayes AW, Karimi G (2021) Protective effects of curcumin on chemical and drug-induced cardiotoxicity: a review. Naunyn Schmiedebergs Arch Pharmacol 394(7):1341\u20131353. https:\/\/doi.org\/10.1007\/s00210-021-02072-8","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"3","key":"12473_CR82","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1177\/0960327120959417","volume":"40","author":"S Zare","year":"2021","unstructured":"Zare S, Heydari F, Hayes A, Reiter R, Zirak M, Karimi G (2021) Melatonin attenuates chemical-induced cardiotoxicity. Hum Exp Toxicol 40(3):383\u2013394. https:\/\/doi.org\/10.1177\/0960327120959417","journal-title":"Hum Exp Toxicol"},{"key":"12473_CR83","doi-asserted-by":"publisher","unstructured":"Ye B, Ling W, Wang Y, Jaisi A, Olatunji OJ (2022) Protective Effects of Chrysin against Cyclophosphamide-Induced Cardiotoxicity in Rats: A Biochemical and Histopathological Approach. Chem Biodivers 19(3). https:\/\/doi.org\/10.1002\/cbdv.202100886 PubMed PMID: 35014174","DOI":"10.1002\/cbdv.202100886"},{"key":"12473_CR84","doi-asserted-by":"publisher","unstructured":"Saleh DO, Elbaset MA, Ahmed KA, Sedik AA (2025) Chrysin mitigates cyclophosphamide-triggered cardiotoxicity in rats: Insights into cardioprotection via Treg expression modulation and iNOS downregulation. Toxicol Rep 14. https:\/\/doi.org\/10.1016\/j.toxrep.2025.102007","DOI":"10.1016\/j.toxrep.2025.102007"},{"issue":"1","key":"12473_CR85","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.ejphar.2014.01.065","volume":"728","author":"EM Mantawy","year":"2014","unstructured":"Mantawy EM, El-Bakly WM, Esmat A, Badr AM, El-Demerdash E (2014) Chrysin alleviates acute doxorubicin cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis. Eur J Pharmacol 728(1):107\u2013118. https:\/\/doi.org\/10.1016\/j.ejphar.2014.01.065 PubMed PMID: 24509133","journal-title":"Eur J Pharmacol"},{"issue":"11","key":"12473_CR86","doi-asserted-by":"publisher","first-page":"181","DOI":"10.36348\/sijap.2023.v06i11.005","volume":"6","author":"IA Egwuatu","year":"2023","unstructured":"Egwuatu IA, Ozoemena CL, Ugwuishi EW, Ozor CC, Oviosun A, Onwene F (2023) Deciphering the Ameliorative Potential of 5, 7-dihydroxyflavone (Chrysin) on Doxorubicin-Induced Cardiotoxicity by Modulating Oxidative Stress in Rats. Scholars Int J Anat Physiol 6(11):181\u2013190. https:\/\/doi.org\/10.36348\/sijap.2023.v06i11.005","journal-title":"Scholars Int J Anat Physiol"},{"issue":"12","key":"12473_CR87","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.14670\/HH-11-641","volume":"30","author":"N Anghel","year":"2015","unstructured":"Anghel N, Cotoraci C, Ivan A, Suciu M, Herman H, Balta C et al (2015) Chrysin attenuates cardiomyocyte apoptosis and loss of intermediate filaments in a mouse model of mitoxantrone cardiotoxicity. Histol Histopathol 30(12):1465\u20131475. https:\/\/doi.org\/10.14670\/HH-11-641 PubMed PMID: 26112963","journal-title":"Histol Histopathol"},{"key":"12473_CR88","doi-asserted-by":"publisher","unstructured":"Zeng X, Yang Y (2024) Molecular Mechanisms Underlying Vascular Remodeling in Hypertension. Reviews in Cardiovascular Medicine. IMR Press Limited. https:\/\/doi.org\/10.31083\/j.rcm2502072","DOI":"10.31083\/j.rcm2502072"},{"key":"12473_CR89","doi-asserted-by":"publisher","unstructured":"Nguyen BA, Alexander MR, Harrison DG (2024) Immune mechanisms in the pathophysiology of hypertension. Nat Reviews Nephrol Nat Res 530\u2013540. https:\/\/doi.org\/10.1038\/s41581-024-00838-w PubMed PMID: 38658669","DOI":"10.1038\/s41581-024-00838"},{"key":"12473_CR90","doi-asserted-by":"publisher","unstructured":"Ma J, Li Y, Yang X, Liu K, Zhang X, Zuo X et al (2023) Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions. Signal Transduction and Targeted Therapy. Springer Nature. https:\/\/doi.org\/10.1038\/s41392-023-01430-7 PubMed PMID: 37080965","DOI":"10.1038\/s41392-023-01430-7"},{"issue":"5","key":"12473_CR91","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1097\/MBP.0000000000000393","volume":"24","author":"M Hrom\u00e1dka","year":"2019","unstructured":"Hrom\u00e1dka M, T\u016fmov\u00e1 P, Rokyta R, Seidlerov\u00e1 J (2019) Blood pressure measurement in patients with cardiogenic shock. Blood Press Monit 24(5):213\u2013220. https:\/\/doi.org\/10.1097\/MBP.0000000000000393","journal-title":"Blood Press Monit"},{"issue":"3","key":"12473_CR92","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1007\/s12291-018-0761-y","volume":"34","author":"R Veerappan","year":"2019","unstructured":"Veerappan R, Malarvili T (2019) Chrysin Pretreatment Improves Angiotensin System, cGMP Concentration in L-NAME Induced Hypertensive Rats. Indian J Clin Biochem 34(3):288\u2013295. https:\/\/doi.org\/10.1007\/s12291-018-0761-y","journal-title":"Indian J Clin Biochem"},{"key":"12473_CR93","doi-asserted-by":"publisher","unstructured":"Tew WY, Tan CS, Yan CS, Loh HW, Wen X, Wei X et al (2023) Evaluation of vasodilatory effect and antihypertensive effect of chrysin through in vitro and sub-chronic in vivo study. Biomed Pharmacotherapy 157. https:\/\/doi.org\/10.1016\/j.biopha.2022.114020 PubMed PMID: 36469968","DOI":"10.1016\/j.biopha.2022.114020"},{"issue":"1","key":"12473_CR94","doi-asserted-by":"publisher","first-page":"20","DOI":"10.4103\/2231-0738.150069","volume":"5","author":"R Veerappan","year":"2015","unstructured":"Veerappan R, Senthilkumar R (2015) Chrysin enhances antioxidants and oxidative stress in L-NAME-induced hypertensive rats. Int J Nutr Pharmacol Neurol Dis 5(1):20\u201327. https:\/\/doi.org\/10.4103\/2231-0738.150069","journal-title":"Int J Nutr Pharmacol Neurol Dis"},{"key":"12473_CR95","doi-asserted-by":"publisher","unstructured":"Islam K, Islam R, Nguyen I, Malik H, Pirzadah H, Shrestha B et al (2025) Diabetes Mellitus and Associated Vascular Disease: Pathogenesis, Complications, and Evolving Treatments. Advances in Therapy. Adis, pp 2659\u20132678. https:\/\/doi.org\/10.1007\/s12325-025-03185-9 PubMed PMID: 40252164","DOI":"10.1007\/s12325-025-03185-9"},{"key":"12473_CR96","doi-asserted-by":"publisher","unstructured":"Di Pietrantonio N, Di Tomo P, Mandatori D, Formoso G, Pandolfi A (2023) Diabetes and Its Cardiovascular Complications: Potential Role of the Acetyltransferase p300. Cells. MDPI. https:\/\/doi.org\/10.3390\/cells12030431 PubMed PMID: 36766773","DOI":"10.3390\/cells12030431"},{"key":"12473_CR97","doi-asserted-by":"publisher","unstructured":"Jyotsna F, Ahmed A, Kumar K, Kaur P, Chaudhary MH, Kumar S et al (2023 Aug) Exploring the Complex Connection Between Diabetes and Cardiovascular Disease: Analyzing Approaches to Mitigate Cardiovascular Risk in Patients With Diabetes. Cureus 22. https:\/\/doi.org\/10.7759\/cureus.43882","DOI":"10.7759\/cureus.43882"},{"key":"12473_CR98","doi-asserted-by":"publisher","unstructured":"Horton WB, Love KM, Gregory JM, Liu Z, Barrett EJ (2025) Metabolic and vascular insulin resistance: partners in the pathogenesis of cardiovascular disease in diabetes. American Journal of Physiology - Heart and Circulatory Physiology. American Physiological Society, pp H1218\u2013H1236. https:\/\/doi.org\/10.1152\/ajpheart.00826.2024 PubMed PMID: 40257392","DOI":"10.1152\/ajpheart.00826"},{"key":"12473_CR99","doi-asserted-by":"publisher","unstructured":"Zakir M, Ahuja N, Surksha MA, Sachdev R, Kalariya Y, Nasir M et al (2023) Cardiovascular Complications of Diabetes: From Microvascular to Macrovascular Pathways. Cureus. 24. https:\/\/doi.org\/10.7759\/cureus.45835","DOI":"10.7759\/cureus.45835"},{"key":"12473_CR100","doi-asserted-by":"publisher","unstructured":"Shah A, Isath A, Aronow WS (2022) Cardiovascular complications of diabetes. Expert Review of Endocrinology and Metabolism. Taylor and Francis Ltd., pp 383\u2013388. https:\/\/doi.org\/10.1080\/17446651.2022.2099838 PubMed PMID: 35831991","DOI":"10.1080\/17446651.2022.2099838"},{"key":"12473_CR101","doi-asserted-by":"publisher","unstructured":"Singh G, Varshney V, Goyal A, Ali N, Iqbal M, Kaur I et al (2023) Chrysin restores the cardioprotective effect of ischemic preconditioning in diabetes-challenged rat heart. Heliyon 9(11). https:\/\/doi.org\/10.1016\/j.heliyon.2023.e22052","DOI":"10.1016\/j.heliyon.2023.e22052"},{"issue":"5","key":"12473_CR102","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1142\/S0192415X14500724","volume":"42","author":"HM El-Bassossy","year":"2014","unstructured":"El-Bassossy HM, Abo-Warda SM, Fahmy A (2014) Chrysin and luteolin alleviate vascular complications associated with insulin resistance mainly through PPAR-\u03b3 activation. Am J Chin Med 42(5):1153\u20131167 doi:10.1142\/S0192415X14500724 PubMed PMID: 25169908","journal-title":"Am J Chin Med"},{"issue":"11","key":"12473_CR103","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1002\/ptr.4917","volume":"27","author":"HM El-Bassossy","year":"2013","unstructured":"El-Bassossy HM, Abo-Warda SM, Fahmy A (2013) Chrysin and luteolin attenuate diabetes-induced impairment in endothelial-dependent relaxation: Effect on lipid profile, AGEs and NO generation. Phytother Res 27(11):1678\u20131684. https:\/\/doi.org\/10.1002\/ptr.4917 PubMed PMID: 23296950","journal-title":"Phytother Res"},{"issue":"6","key":"12473_CR104","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1093\/jpp\/rgae140","volume":"77","author":"N Rani","year":"2025","unstructured":"Rani N, Arya DS (2025) Modulation of PPAR-\u03b3\/Nrf2 and AGE\/RAGE signaling contributes to the chrysin cardioprotection against myocardial damage following ischemia\/reperfusion in diabetic rats. J Pharm Pharmacol 77(6):794\u2013804. https:\/\/doi.org\/10.1093\/jpp\/rgae140 PubMed PMID: 39673242","journal-title":"J Pharm Pharmacol"},{"issue":"6","key":"12473_CR105","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.jnutbio.2011.03.011","volume":"23","author":"HM Lo","year":"2012","unstructured":"Lo HM, Wu MW, Pan SL, Peng CY, Wu PH, Wu W, Bin (2012) Chrysin restores PDGF-induced inhibition on protein tyrosine phosphatase and reduces PDGF signaling in cultured VSMCs. J Nutr Biochem 23(6):667\u2013678 .011 PubMed PMID: 21803557","journal-title":"J Nutr Biochem"},{"key":"12473_CR106","doi-asserted-by":"publisher","unstructured":"Ravishankar D, Salamah M, Attina A, Pothi R, Vallance TM, Javed M et al (2017) Ruthenium-conjugated chrysin analogues modulate platelet activity, thrombus formation and haemostasis with enhanced efficacy. Sci Rep 7(1). https:\/\/doi.org\/10.1038\/s41598-017-05936-3 PubMed PMID: 28720875","DOI":"10.1038\/s41598-017-05936-3"},{"issue":"1","key":"12473_CR107","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1007\/s11033-025-10529-9","volume":"52","author":"J Ma","year":"2025","unstructured":"Ma J, Li Y, Tang Y, Qian G, Lv H, Song X et al (2025) Chrysin improves endothelial inflammation via the NFAT pathway in Kawasaki disease. Mol Biol Rep 52(1):428. https:\/\/doi.org\/10.1007\/s11033-025-10529-9","journal-title":"Mol Biol Rep"},{"issue":"5","key":"12473_CR108","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1002\/ddr.21954","volume":"83","author":"R Kamel","year":"2022","unstructured":"Kamel R, El Morsy EM, Elsherbiny ME, Nour-Eldin M (2022) Chrysin promotes angiogenesis in rat hindlimb ischemia: Impact on PI3K\/Akt\/mTOR signaling pathway and autophagy. Drug Dev Res 83(5):1226\u20131237. https:\/\/doi.org\/10.1002\/ddr.21954 PubMed PMID: 35662099","journal-title":"Drug Dev Res"},{"issue":"7","key":"12473_CR109","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1017\/S0007114522000472","volume":"129","author":"S Meshram","year":"2023","unstructured":"Meshram S, Verma VK, Mutneja E, Sahu AK, Malik S, Mishra P et al (2023) Evidence-based mechanistic role of chrysin towards protection of cardiac hypertrophy and fibrosis in rats. Br J Nutr 129(7):1105\u20131118 doi:10.1017\/S0007114522000472 PubMed PMID: 35177130","journal-title":"Br J Nutr"},{"issue":"3","key":"12473_CR110","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1177\/1074248418810809","volume":"24","author":"S Zhao","year":"2019","unstructured":"Zhao S, Liang M, Wang Y, Hu J, Zhong Y, Li J et al (2019) Chrysin Suppresses Vascular Endothelial Inflammation via Inhibiting the NF-\u03baB Signaling Pathway. J Cardiovasc Pharmacol Ther 24(3):278\u2013287 doi:10.1177\/1074248418810809 PubMed PMID: 30497287","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"12473_CR111","doi-asserted-by":"publisher","first-page":"108801","DOI":"10.1016\/j.pharmthera.2025.108801","volume":"267","author":"Z Wang","year":"2025","unstructured":"Wang Z, Liu J, Chen Y, Tang Y, Chen T, Zhou C et al (2025) From physiology to pathology: Emerging roles of GPER in cardiovascular disease. Pharmacol Ther 267:108801. https:\/\/doi.org\/10.1016\/j.pharmthera.2025.108801","journal-title":"Pharmacol Ther"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12473-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12473-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12473-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:01:38Z","timestamp":1784898098000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12473-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":111,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12473"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12473-8","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,24]]},"assertion":[{"value":"18 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Informed Consent","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1256"}}