{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:58:10Z","timestamp":1785455890240,"version":"3.56.0"},"reference-count":124,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12482-7","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:29:01Z","timestamp":1785407341000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Emerging biomarkers in breast fibroadenoma: implications for differential diagnosis, malignant transformation, and precision medicine"],"prefix":"10.1007","volume":"53","author":[{"given":"Nishaa","family":"Ravi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roopika","family":"Sankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anugraha","family":"Mathavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh Kumar","family":"Rayala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh","family":"Venkatraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhawna","family":"Dev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"12482_CR1","doi-asserted-by":"publisher","first-page":"103851","DOI":"10.1016\/j.breast.2024.103851","volume":"79","author":"L Liao","year":"2025","unstructured":"Liao L (2025) Inequality in breast cancer: Global statistics from 2022 to 2050. Breast 79:103851","journal-title":"Breast"},{"key":"12482_CR2","doi-asserted-by":"crossref","unstructured":"Kim J, Harper A, McCormack V, Sung H, Houssami N, Morgan E, Mutebi M, Garvey G, Soerjomataram I, Fidler-Benaoudia MM (2025) Global patterns and trends in breast cancer incidence and mortality across 185 countries. Nat Med 1\u20139","DOI":"10.1038\/s41591-025-03502-3"},{"issue":"2","key":"12482_CR3","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.prp.2018.12.023","volume":"215","author":"S Radenkovic","year":"2019","unstructured":"Radenkovic S, Konjevic G, Gavrilovic D, Stojanovic-Rundic S, Plesinac-Karapandzic V, Stevanovic P, Jurisic V (2019) pSTAT3 expression associated with survival and mammographic density of breast cancer patients. Pathol Res Pract 215(2):366\u2013372. https:\/\/doi.org\/10.1016\/j.prp.2018.12.023","journal-title":"Pathol Res Pract"},{"key":"12482_CR4","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.bbe.2024.01.002","volume":"44","author":"X Wen","year":"2024","unstructured":"Wen X, Guo X, Wang S, Lu Z, Zhang Y (2024) Breast cancer diagnosis: A systematic review. Biocybernetics Biomedical Eng 44:119\u2013148","journal-title":"Biocybernetics Biomedical Eng"},{"key":"12482_CR5","doi-asserted-by":"publisher","unstructured":"Jurisic V, Radenkovic S, Konjevic G (2015) The Actual Role of LDH as Tumor Marker, Biochemical and Clinical Aspects. Advances in Experimental Medicine and Biology. ;867:115\u2013124. https:\/\/doi.org\/10.1007\/978-94-017-7215-0_8. PMID: 26530363","DOI":"10.1007\/978-94-017-7215-0_8"},{"issue":"1\u20132","key":"12482_CR6","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1093\/rpd\/ncu243","volume":"162","author":"S Radenkovic","year":"2014","unstructured":"Radenkovic S, Konjevic G, Isakovic A, Stevanovic P, Gopcevic K, Jurisic V (2014) HER2-positive breast cancer patients: correlation between mammographic and pathological findings. Radiat Prot Dosimetry 162(1\u20132):125\u2013128. https:\/\/doi.org\/10.1093\/rpd\/ncu243","journal-title":"Radiat Prot Dosimetry"},{"key":"12482_CR7","doi-asserted-by":"crossref","unstructured":"Ramala SR Jr, Chandak S, Chandak MS, Annareddy S, Annareddy Jr (2023) S. A comprehensive review of breast fibroadenoma: Correlating clinical and pathological findings. Cureus 15","DOI":"10.7759\/cureus.49948"},{"key":"12482_CR8","doi-asserted-by":"crossref","first-page":"204798161557227","DOI":"10.1177\/2047981615572273","volume":"4","author":"LM Sanders","year":"2015","unstructured":"Sanders LM, Sara R (2015) The growing fibroadenoma. Acta Radiol Open 4:2047981615572273","journal-title":"Acta Radiol Open"},{"key":"12482_CR9","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1111\/his.12712","volume":"67","author":"S Piscuoglio","year":"2015","unstructured":"Piscuoglio S, Murray M, Fusco N, Marchi\u00f2 C, Loo FL, Martelotto LG, Schultheis AM, Akram M, Weigelt B, Brogi E (2015) MED12 somatic mutations in fibroadenomas and phyllodes tumours of the breast. Histopathology 67:719\u2013729","journal-title":"Histopathology"},{"key":"12482_CR10","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.3390\/biom12081021","volume":"12","author":"VK Sarhadi","year":"2022","unstructured":"Sarhadi VK, Armengol G (2022) Molecular biomarkers in cancer. Biomolecules 12:1021","journal-title":"Biomolecules"},{"key":"12482_CR11","first-page":"8","volume":"1","author":"EI Obeagu","year":"2023","unstructured":"Obeagu EI, Ahmed YA, Obeagu GU, Bunu U, Ugwu O, Alum EU (2023) Biomarkers of breast cancer: Overview. Int J Curr Res Biology Med 1:8\u201316","journal-title":"Int J Curr Res Biology Med"},{"key":"12482_CR12","doi-asserted-by":"crossref","unstructured":"Pandit P, Murkey SP, Agarwal A, Jaiswal A, Agrawal S, Agarwal (2023) IV, A. Understanding fibroadenoma of the breast: A comprehensive review of pre-operative and post-operative clinicopathological correlations. Cureus 15","DOI":"10.7759\/cureus.51329"},{"key":"12482_CR13","doi-asserted-by":"publisher","first-page":"3211","DOI":"10.5958\/0974-360X.2017.00570.4","volume":"10","author":"V Jayashree","year":"2017","unstructured":"Jayashree V, Velraj M (2017) Breast Cancer and various Prognostic Biomarkers for the diagnosis of the disease: A Review. Res J Pharm Technol 10:3211\u20133216","journal-title":"Res J Pharm Technol"},{"key":"12482_CR14","doi-asserted-by":"publisher","first-page":"13407","DOI":"10.3390\/ijms241713407","volume":"24","author":"B Milosevic","year":"2023","unstructured":"Milosevic B, Stojanovic B, Cvetkovic A, Jovanovic I, Spasic M, Stojanovic MD, Stankovic V, Sekulic M, Stojanovic BS, Zdravkovic N (2023) The enigma of mammaglobin: Redefining the biomarker paradigm in breast carcinoma. Int J Mol Sci 24:13407","journal-title":"Int J Mol Sci"},{"key":"12482_CR15","doi-asserted-by":"publisher","first-page":"020","DOI":"10.1055\/s-0042-1747678","volume":"15","author":"M Fatima","year":"2023","unstructured":"Fatima M, Baba KSS, Sreedevi NN, Kumar JP, Raju GS, Uppin SG, Bhaskar MV, Khan SA, Iyyapu KM, Noorjahan M (2023) Evaluation of Serum Mammaglobin as an Alternative Biomarker in the Diagnosis of Breast Tumors. J Lab Physicians 15:020\u2013024","journal-title":"J Lab Physicians"},{"key":"12482_CR16","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1111\/tbj.12863","volume":"24","author":"S De Lara","year":"2018","unstructured":"De Lara S, Parris TZ, Werner R\u00f6nnerman E, Helou K, Kov\u00e1cs A (2018) GATA 3 as a putative marker of breast cancer metastasis\u2014A retrospective immunohistochemical study. Breast J 24:184\u2013188","journal-title":"Breast J"},{"key":"12482_CR17","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1016\/j.humpath.2014.06.022","volume":"45","author":"G Krings","year":"2014","unstructured":"Krings G, Nystrom M, Mehdi I, Vohra P, Chen Y-Y (2014) Diagnostic utility and sensitivities of GATA3 antibodies in triple-negative breast cancer. Hum Pathol 45:2225\u20132232","journal-title":"Hum Pathol"},{"key":"12482_CR18","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1293\/tox.2014-0008","volume":"27","author":"Y Kinoshita","year":"2014","unstructured":"Kinoshita Y, Yoshizawa K, Emoto Y, Yuki M, Yuri T, Shikata N, Tsubura A (2014) Similarity of GATA-3 expression between rat and human mammary glands. J Toxicologic Pathol 27:159\u2013162","journal-title":"J Toxicologic Pathol"},{"key":"12482_CR19","doi-asserted-by":"crossref","unstructured":"Shalannandia WA, Chou Y, Bashari MH, Khairani AF (2024) Intermediate filaments in breast cancer progression, and potential biomarker for cancer therapy: A narrative review. Breast Cancer: Targets Therapy 689\u2013704","DOI":"10.2147\/BCTT.S489953"},{"key":"12482_CR20","doi-asserted-by":"publisher","first-page":"035","DOI":"10.17352\/acp.000013","volume":"5","author":"M Bernardo","year":"2020","unstructured":"Bernardo M, Franco AV, Facina G, Waitzberg A (2020) Immunohystochemical profile of cytokeratins (5, 7, 14, 18, 20) in retrospective cases of breast fibroadenomas. Annals Cytol Pathol 5:035\u2013043","journal-title":"Annals Cytol Pathol"},{"key":"12482_CR21","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.14260\/jemds\/2020\/553","volume":"35","author":"P Mishra","year":"2020","unstructured":"Mishra P, Vagha S, Shukla S, Acharya S, Goyal A (2020) Assessment of cytokeratin expression in carcinoma breast. J Evol Med Dent Sci 35:2545\u20132549","journal-title":"J Evol Med Dent Sci"},{"key":"12482_CR22","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1177\/1535370217750088","volume":"243","author":"RM Califf","year":"2018","unstructured":"Califf RM (2018) Biomarker definitions and their applications. Experimental Biology Med 243:213\u2013221","journal-title":"Experimental Biology Med"},{"key":"12482_CR23","doi-asserted-by":"publisher","first-page":"4455","DOI":"10.3390\/cancers13174455","volume":"13","author":"MG Davey","year":"2021","unstructured":"Davey MG, Hynes SO, Kerin MJ, Miller N, Lowery AJ (2021) Ki-67 as a prognostic biomarker in invasive breast cancer. Cancers 13:4455","journal-title":"Cancers"},{"key":"12482_CR24","doi-asserted-by":"publisher","first-page":"S67","DOI":"10.1016\/j.breast.2015.07.017","volume":"24","author":"C Denkert","year":"2015","unstructured":"Denkert C, Budczies J, von Minckwitz G, Wienert S, Loibl S, Klauschen F (2015) Strategies for developing Ki67 as a useful biomarker in breast cancer. Breast 24:S67\u2013S72","journal-title":"Breast"},{"key":"12482_CR25","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1309\/F523-FMJV-W886-3J38","volume":"115","author":"A Kuijper","year":"2001","unstructured":"Kuijper A, Mommers EC, van der Wall E, van Diest PJ (2001) Histopathology of fibroadenoma of the breast. Am J Clin Pathol 115:736\u2013742","journal-title":"Am J Clin Pathol"},{"key":"12482_CR26","doi-asserted-by":"publisher","first-page":"80","DOI":"10.7150\/oncm.18416","volume":"2","author":"M Assem","year":"2017","unstructured":"Assem M, Youssef EA, Rashad RM, Yahia MA-H (2017) Immunohistochemical expression of cyclin d1 in invasive ductal carcinoma of human breast. Oncomedicine 2:80\u201387","journal-title":"Oncomedicine"},{"key":"12482_CR27","doi-asserted-by":"publisher","unstructured":"Radenkovic S, Konjevic G, Gavrilovic D et al (2019) pSTAT3 expression associated with survival and mammographic density of breast cancer patients. Pathology, Research and Practice. ;215(2):366\u2013372. https:\/\/doi.org\/10.1016\/j.prp.2018.12.023. PMID: 30598340","DOI":"10.1016\/j.prp.2018.12.023"},{"key":"12482_CR28","doi-asserted-by":"publisher","first-page":"153303382098308","DOI":"10.1177\/1533033820983081","volume":"19","author":"VN Chu","year":"2020","unstructured":"Chu VN, Nguyen QT, Vu HTN, Phung HT, Pham KH, Le RD (2020) Combined p53 and Bcl2 immunophenotypes in prognosis of vietnamese invasive breast carcinoma: A single institutional retrospective analysis. Technol Cancer Res Treat 19:1533033820983081","journal-title":"Technol Cancer Res Treat"},{"key":"12482_CR29","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.steroids.2004.10.013","volume":"70","author":"R Cericatto","year":"2005","unstructured":"Cericatto R, Pozzobon A, Morsch D, Menke C, Brum I, Spritzer P (2005) Estrogen receptor-\u03b1, bcl-2 and c-myc gene expression in fibroadenomas and adjacent normal breast: Association with nodule size, hormonal and reproductive features. Steroids 70:153\u2013160","journal-title":"Steroids"},{"key":"12482_CR30","doi-asserted-by":"crossref","unstructured":"Nicolini A, Ferrari P, Duffy MJ (2018) Prognostic and predictive biomarkers in breast cancer: Past, present and future. Sem Cancer Biol 56\u201373","DOI":"10.1016\/j.semcancer.2017.08.010"},{"key":"12482_CR31","doi-asserted-by":"publisher","first-page":"R41","DOI":"10.1530\/EJE-16-0124","volume":"175","author":"C J","year":"2016","unstructured":"J C (2016) Mechanisms of oestrogen receptor (ER) gene regulation in breast cancer. Eur J Endocrinol 175:R41\u2013R49","journal-title":"Eur J Endocrinol"},{"key":"12482_CR32","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s12020-009-9176-0","volume":"35","author":"G Branchini","year":"2009","unstructured":"Branchini G, Schneider L, Cericatto R, Capp E, Brum IS (2009) Progesterone receptors A and B and estrogen receptor alpha expression in normal breast tissue and fibroadenomas. Endocrine 35:459\u2013466","journal-title":"Endocrine"},{"key":"12482_CR33","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1146\/annurev-med-042513-015127","volume":"66","author":"MF Rimawi","year":"2015","unstructured":"Rimawi MF, Schiff R, Osborne CK (2015) Targeting HER2 for the treatment of breast cancer. Annu Rev Med 66:111\u2013128","journal-title":"Annu Rev Med"},{"key":"12482_CR34","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1634\/theoncologist.2014-0334","volume":"20","author":"M Hicks","year":"2015","unstructured":"Hicks M, Macrae ER, Abdel-Rasoul M, Layman R, Friedman S, Querry J, Lustberg M, Ramaswamy B, Mrozek E, Shapiro C (2015) Neoadjuvant dual HER2-targeted therapy with lapatinib and trastuzumab improves pathologic complete response in patients with early stage HER2-positive breast cancer: a meta-analysis of randomized prospective clinical trials. Oncologist 20:337\u2013343","journal-title":"Oncologist"},{"key":"12482_CR35","doi-asserted-by":"publisher","first-page":"302","DOI":"10.4103\/bbrj.bbrj_221_25","volume":"9","author":"MA Hayawi","year":"2025","unstructured":"Hayawi MA, Al-Saleem IAAA (2025) Immunohistochemical and Histopathological Study of Patients with Breast Fibroadenoma. Biomedical Biotechnol Res J 9:302\u2013308","journal-title":"Biomedical Biotechnol Res J"},{"key":"12482_CR36","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1093\/annonc\/mdw246","volume":"27","author":"S Goel","year":"2016","unstructured":"Goel S, Krop I (2016) PIK3CA mutations in HER2-positive breast cancer: an ongoing conundrum. Ann Oncol 27:1368\u20131372","journal-title":"Ann Oncol"},{"key":"12482_CR37","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/s41416-018-0127-5","volume":"119","author":"NM Tung","year":"2018","unstructured":"Tung NM, Garber JE (2018) BRCA 1\/2 testing: therapeutic implications for breast cancer management. Br J Cancer 119:141\u2013152","journal-title":"Br J Cancer"},{"key":"12482_CR38","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3343\/alm.2020.40.2.114","volume":"40","author":"C Albert","year":"2020","unstructured":"Albert C, Haase M, Albert A, Kropf S, Bellomo R, Westphal S, Westerman M, Braun-Dullaeus RC, Haase-Fielitz A, Lee A (2020) BRCA1\/BRCA2 pathogenic variant breast cancer: treatment and prevention strategies. Annals Lab Med 40:114\u2013121","journal-title":"Annals Lab Med"},{"key":"12482_CR39","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1080\/15384047.2019.1579955","volume":"20","author":"J Moes-Sosnowska","year":"2019","unstructured":"Moes-Sosnowska J, Rzepecka IK, Chodzynska J, Dansonka-Mieszkowska A, Szafron LM, Balabas A, Lotocka R, Sobiczewski P, Kupryjanczyk J (2019) Clinical importance of FANCD2, BRIP1, BRCA1, BRCA2 and FANCF expression in ovarian carcinomas. Cancer Biol Ther 20:843\u2013854","journal-title":"Cancer Biol Ther"},{"key":"12482_CR40","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1038\/ng.3037","volume":"46","author":"WK Lim","year":"2014","unstructured":"Lim WK, Ong CK, Tan J, Thike AA, Ng CCY, Rajasegaran V, Myint SS, Nagarajan S, Nasir NDM, McPherson JR (2014) Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma. Nat Genet 46:877\u2013880","journal-title":"Nat Genet"},{"key":"12482_CR41","doi-asserted-by":"publisher","first-page":"101536","DOI":"10.1016\/j.suronc.2021.101536","volume":"37","author":"JPY Lee","year":"2021","unstructured":"Lee JPY, Thomas AJ, Lum SK, Shamsudin NH, Hii L-W, Mai C-W, Wong S-F, Leong C-O (2021) Gene expression profiling of giant fibroadenomas of the breast. Surg Oncol 37:101536","journal-title":"Surg Oncol"},{"key":"12482_CR42","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.acthis.2016.05.002","volume":"118","author":"M Jur\u00edkov\u00e1","year":"2016","unstructured":"Jur\u00edkov\u00e1 M, Danihel \u013d, Pol\u00e1k \u0160, Varga I (2016) Ki67, PCNA, and MCM proteins: Markers of proliferation in the diagnosis of breast cancer. Acta Histochem 118:544\u2013552","journal-title":"Acta Histochem"},{"key":"12482_CR43","doi-asserted-by":"publisher","first-page":"5679","DOI":"10.3390\/ijms23105679","volume":"23","author":"Y-L Wang","year":"2022","unstructured":"Wang Y-L, Wu W-R, Lin P-L, Shen Y-C, Lin Y-Z, Li H-W, Hsu K-W, Wang S-C (2022) The functions of PCNA in tumor stemness and invasion. Int J Mol Sci 23:5679","journal-title":"Int J Mol Sci"},{"key":"12482_CR44","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1046\/j.1524-4741.2003.09410.x","volume":"9","author":"J Bernardes Jr","year":"2003","unstructured":"Bernardes J Jr, Seixas M, Lima G, Marinho L, Gebrim L (2003) The effect of tamoxifen on PCNA expression in fibroadenomas. Breast J 9:302\u2013306","journal-title":"Breast J"},{"key":"12482_CR45","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.neo.2019.07.011","volume":"21","author":"MSM Issac","year":"2019","unstructured":"Issac MSM, Yousef E, Tahir MR, Gaboury LA (2019) MCM2, MCM4, and MCM6 in breast cancer: clinical utility in diagnosis and prognosis. Neoplasia 21:1015\u20131035","journal-title":"Neoplasia"},{"key":"12482_CR46","doi-asserted-by":"publisher","first-page":"e70626","DOI":"10.1002\/hsr2.70626","volume":"8","author":"A Salahi-Niri","year":"2025","unstructured":"Salahi-Niri A, Zarand P, Shojaeian F, Mansouri N, Yazdani O, Esbati R, Safavi\u2010Naini SAA, Jahanbin B (2025) Proliferative Markers in Breast Cancer and Chemotherapy Implications: A Comprehensive Review. Health Sci Rep 8:e70626","journal-title":"Health Sci Rep"},{"key":"12482_CR47","doi-asserted-by":"publisher","first-page":"351","DOI":"10.15171\/apb.2015.049","volume":"5","author":"S Sharifi","year":"2015","unstructured":"Sharifi S, Barar J, Hejazi MS, Samadi N (2015) Doxorubicin changes Bax\/Bcl-xL ratio, caspase-8 and 9 in breast cancer cells. Adv Pharm Bull 5:351","journal-title":"Adv Pharm Bull"},{"key":"12482_CR48","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1186\/1471-2407-6-213","volume":"6","author":"AA Fiebig","year":"2006","unstructured":"Fiebig AA, Zhu W, Hollerbach C, Leber B, Andrews DW (2006) Bcl-XL is qualitatively different from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line. BMC Cancer 6:213","journal-title":"BMC Cancer"},{"key":"12482_CR49","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1080\/1120009X.2023.2278014","volume":"36","author":"H Dou","year":"2024","unstructured":"Dou H, Yu PY, Liu YQ, Zhu Y, Li FC, Wang YY, Chen XY, Xiao M (2024) Recent advances in caspase-3, breast cancer, and traditional Chinese medicine: a review. J Chemother 36:370\u2013388","journal-title":"J Chemother"},{"key":"12482_CR50","unstructured":"Jha K, Shukla M, Kumar M, Shukla VK, Pandey M (2017) Expression of caspase 3 and inhibition of apoptosis lowers survival in breast cancer. World J Surg Med Radiation Oncol 6"},{"key":"12482_CR51","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.1158\/1078-0432.CCR-23-1526","volume":"30","author":"YJ Han","year":"2024","unstructured":"Han YJ, Liu S, Hardeman A, Rajagopal PS, Mueller J, Khramtsova G, Sanni A, Ajani M, Clayton W, Hurley IW (2024) The VEGF-Hypoxia signature is upregulated in basal-like breast tumors from women of African ancestry and associated with poor outcomes in breast cancer. Clin Cancer Res 30:2609\u20132618","journal-title":"Clin Cancer Res"},{"key":"12482_CR52","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.3390\/jcm12062412","volume":"12","author":"KK Brogowska","year":"2023","unstructured":"Brogowska KK, Zajkowska M, Mroczko B (2023) Vascular endothelial growth factor ligands and receptors in breast cancer. J Clin Med 12:2412","journal-title":"J Clin Med"},{"key":"12482_CR53","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1177\/0394632016681306","volume":"30","author":"AI Autenshlyus","year":"2017","unstructured":"Autenshlyus AI, Arkhipov SA, Kunts TA, Marinkin IO, Mikhailova ES, Karpukhina XV, Varaksin NA (2017) Cytokine profiles of tumor supernatants in invasive ductal cancer and fibroadenoma of the breast and its relationship with VEGF-A expression in the tumors. Int J ImmunoPathol Pharmacol 30:83\u201388","journal-title":"Int J ImmunoPathol Pharmacol"},{"key":"12482_CR54","first-page":"660","volume":"8","author":"P Li","year":"2015","unstructured":"Li P, He Q, Luo C, Qian L (2015) Diagnostic and prognostic potential of serum angiopoietin-2 expression in human breast cancer. Int J Clin Exp Pathol 8:660","journal-title":"Int J Clin Exp Pathol"},{"key":"12482_CR55","first-page":"263","volume":"35","author":"L Jie","year":"2008","unstructured":"Jie L, Jian-dong F, Zhen-xian L, Ai-hua B, Xiao-li Z, Ying Z (2008) Expression and Significance of Ang-2 and VEGF in Breast Carcinoma. Cancer Res Prev Treat 35:263\u2013265","journal-title":"Cancer Res Prev Treat"},{"key":"12482_CR56","doi-asserted-by":"publisher","first-page":"1108695","DOI":"10.3389\/fonc.2022.1108695","volume":"12","author":"MJ Kwon","year":"2023","unstructured":"Kwon MJ (2023) Matrix metalloproteinases as therapeutic targets in breast cancer. Front Oncol 12:1108695","journal-title":"Front Oncol"},{"key":"12482_CR57","first-page":"5865","volume":"14","author":"H Li","year":"2017","unstructured":"Li H, Qiu Z, Li F, Wang C (2017) The relationship between MMP-2 and MMP-9 expression levels with breast cancer incidence and prognosis. Oncol Lett 14:5865\u20135870","journal-title":"Oncol Lett"},{"key":"12482_CR58","doi-asserted-by":"publisher","first-page":"e0135544","DOI":"10.1371\/journal.pone.0135544","volume":"10","author":"F Ren","year":"2015","unstructured":"Ren F, Tang R, Zhang X, Madushi WM, Luo D, Dang Y, Li Z, Wei K, Chen G (2015) Overexpression of MMP family members functions as prognostic biomarker for breast cancer patients: a systematic review and meta-analysis. PLoS ONE 10:e0135544","journal-title":"PLoS ONE"},{"key":"12482_CR59","doi-asserted-by":"crossref","unstructured":"Martins LM, Dourado CSdME, Campos-Verdes LM, Sampaio FA, Revoredo CMS, Costa-Silva DR; da Concei\u00e7\u00e3o, Barros-Oliveira M, Junior EdJN, do Rego-Medeiros LM, Gebrim LH (2019) Expression of matrix metalloproteinase 2 and 9 in breast cancer and breast fibroadenoma: a randomized, double-blind study. Oncotarget 10, 6879","DOI":"10.18632\/oncotarget.27347"},{"key":"12482_CR60","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1590\/1806-9282.20201015","volume":"67","author":"LM Martins","year":"2021","unstructured":"Martins LM, Barros IS, Ferreira EdS, Silva AGd, Dourado CS, Oliveira VAd, Oliveira ARS, Morais JBS, Marreiro DdN, Silva BB (2021) .d. Expression of metalloproteinases 2 and 9 and plasma zinc concentrations in women with fibroadenoma. Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira 67:806\u2013810","journal-title":"Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"},{"key":"12482_CR61","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/s41586-019-1526-3","volume":"573","author":"V Padmanaban","year":"2019","unstructured":"Padmanaban V, Krol I, Suhail Y, Szczerba BM, Aceto N, Bader JS, Ewald AJ (2019) E-cadherin is required for metastasis in multiple models of breast cancer. Nature 573:439\u2013444","journal-title":"Nature"},{"key":"12482_CR62","doi-asserted-by":"publisher","first-page":"8498","DOI":"10.18632\/aging.204357","volume":"14","author":"S-C Ku","year":"2022","unstructured":"Ku S-C, Liu H-L, Su C-Y, Yeh I-J, Yen M-C, Anuraga G, Ta HDK, Chiao C-C, Xuan DTM, Prayugo FB (2022) Comprehensive analysis of prognostic significance of cadherin (CDH) gene family in breast cancer. Aging 14:8498","journal-title":"Aging"},{"key":"12482_CR63","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41523-020-0169-8","volume":"6","author":"L Zhang","year":"2020","unstructured":"Zhang L, Yang C, Pfeifer JD, Caprioli RM, Judd AM, Patterson NH, Reyzer ML, Norris JL, Maluf HM (2020) Histopathologic, immunophenotypic, and proteomics characteristics of low-grade phyllodes tumor and fibroadenoma: more similarities than differences. NPJ Breast Cancer 6:27","journal-title":"NPJ Breast Cancer"},{"key":"12482_CR64","doi-asserted-by":"publisher","first-page":"4006","DOI":"10.1200\/JCO.2009.27.5388","volume":"28","author":"S Liu","year":"2010","unstructured":"Liu S, Wicha MS (2010) Targeting breast cancer stem cells. J Clin Oncol 28:4006\u20134012","journal-title":"J Clin Oncol"},{"key":"12482_CR65","doi-asserted-by":"publisher","first-page":"689839","DOI":"10.3389\/fonc.2021.689839","volume":"11","author":"MA Shadbad","year":"2021","unstructured":"Shadbad MA, Hosseinkhani N, Asadzadeh Z, Derakhshani A, Ahangar NK, Hemmat N, Lotfinejad P, Brunetti O, Silvestris N, Baradaran B (2021) A systematic review to clarify the prognostic values of CD44 and CD44\u2009+\u2009CD24-phenotype in triple-negative breast cancer patients: lessons learned and the road ahead. Front Oncol 11:689839","journal-title":"Front Oncol"},{"key":"12482_CR66","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s12032-010-9530-3","volume":"28","author":"A Giatromanolaki","year":"2011","unstructured":"Giatromanolaki A, Sivridis E, Fiska A, Koukourakis MI (2011) The CD44+\/CD24\u2009\u2013\u2009phenotype relates to \u2018triple-negative\u2019 state and unfavorable prognosis in breast cancer patients. Med Oncol 28:745\u2013752","journal-title":"Med Oncol"},{"key":"12482_CR67","doi-asserted-by":"publisher","first-page":"3765","DOI":"10.3390\/cancers12123765","volume":"12","author":"X Zhang","year":"2020","unstructured":"Zhang X, Powell K, Li L (2020) Breast cancer stem cells: biomarkers, identification and isolation methods, regulating mechanisms, cellular origin, and beyond. Cancers 12:3765","journal-title":"Cancers"},{"key":"12482_CR68","doi-asserted-by":"publisher","first-page":"413","DOI":"10.30699\/ijp.2022.539042.2727","volume":"17","author":"A Alizamir","year":"2022","unstructured":"Alizamir A, Azad SD, Pirdehghan A, Moradi A (2022) Preoperative neutrophil: lymphocyte ratio, platelet: lymphocyte ratio, and C-reactive protein levels predictive value in determining the severity of breast mass. Iran J Pathol 17:413","journal-title":"Iran J Pathol"},{"key":"12482_CR69","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s43042-024-00571-w","volume":"25","author":"BA Ibrahim","year":"2024","unstructured":"Ibrahim BA, Nagdy ES, Nour Eldin E, Khalil AM, El-Taher AK (2024) Assessment of interleukin-6 and cathepsin-B gene expression in breast cancer women. Egypt J Med Hum Genet 25:95","journal-title":"Egypt J Med Hum Genet"},{"key":"12482_CR70","doi-asserted-by":"publisher","first-page":"12958","DOI":"10.1002\/jcb.28567","volume":"120","author":"B Wang","year":"2019","unstructured":"Wang B, Zhang Z, Xia Sa, Jiang M, Wang Y (2019) Expression of \u03b3-H2AX and patient prognosis in breast cancer cohort. J Cell Biochem 120:12958\u201312965","journal-title":"J Cell Biochem"},{"key":"12482_CR71","doi-asserted-by":"publisher","first-page":"101042831987853","DOI":"10.1177\/1010428319878536","volume":"41","author":"PV Varvara","year":"2019","unstructured":"Varvara PV, Karaolanis G, Valavanis C, Stanc G, Tzaida O, Trihia H, Patapis P, Dimitroulis D, Perrea D (2019) gamma-H2AX: A potential biomarker in breast cancer. Tumor Biology 41:1010428319878536","journal-title":"Tumor Biology"},{"key":"12482_CR72","first-page":"759","volume":"137","author":"A Bhatia","year":"2013","unstructured":"Bhatia A, Dey P, Goel S, Singh G (2013) Expression of \u03b3H2AX may help in defining a genetically more stable subtype of infiltrating ductal carcinoma of breast. Indian J Med Res 137:759\u2013766","journal-title":"Indian J Med Res"},{"key":"12482_CR73","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1186\/s13058-014-0475-x","volume":"16","author":"KM Timms","year":"2014","unstructured":"Timms KM, Abkevich V, Hughes E, Neff C, Reid J, Morris B, Kalva S, Potter TV, Chen J (2014) Association of BRCA1\/2 defects with genomic scores predictive of DNA damage repair deficiency among breast cancer subtypes. Breast Cancer Res 16:475","journal-title":"Breast Cancer Res"},{"key":"12482_CR74","first-page":"1617","volume":"7","author":"MC Louie","year":"2017","unstructured":"Louie MC, Sevigny MB (2017) Steroid hormone receptors as prognostic markers in breast cancer. Am J Cancer Res 7:1617","journal-title":"Am J Cancer Res"},{"key":"12482_CR75","doi-asserted-by":"crossref","unstructured":"Li Z, Wei H, Li S, Wu P, Mao X (2022) The role of progesterone receptors in breast cancer. Drug Des Devel Ther 305\u2013314","DOI":"10.2147\/DDDT.S336643"},{"key":"12482_CR76","doi-asserted-by":"publisher","first-page":"492","DOI":"10.3389\/fendo.2018.00492","volume":"9","author":"P Giovannelli","year":"2018","unstructured":"Giovannelli P, Di Donato M, Galasso G, Di Zazzo E, Bilancio A, Migliaccio A (2018) The androgen receptor in breast cancer. Front Endocrinol 9:492","journal-title":"Front Endocrinol"},{"key":"12482_CR77","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s13402-012-0106-4","volume":"35","author":"R Bhagat","year":"2012","unstructured":"Bhagat R, Chadaga S, Premalata C, Ramesh G, Ramesh C, Pallavi V, Krishnamoorthy L (2012) Aberrant promoter methylation of the RASSF1A and APC genes in epithelial ovarian carcinoma development. Cell Oncol 35:473\u2013479","journal-title":"Cell Oncol"},{"key":"12482_CR78","doi-asserted-by":"publisher","first-page":"208","DOI":"10.21873\/cgp.20497","volume":"22","author":"S Dasi","year":"2025","unstructured":"Dasi S, Naab TJ, Kwabi-Addo B, Apprey V, Beyene D, DEWITTY RL, Nagel S, Williams R, Bolden K, Hayes-Dixon A (2025) Methylation of ESR\u03b1 Promoters in Benign Breast Tumors Could Be a Signature for Progression to Breast Cancer in African American Women. Cancer Genomics Proteom 22:208\u2013230","journal-title":"Cancer Genomics Proteom"},{"key":"12482_CR79","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1186\/s12885-015-1777-9","volume":"15","author":"GH Rauscher","year":"2015","unstructured":"Rauscher GH, Kresovich JK, Poulin M, Yan L, Macias V, Mahmoud AM, Al-Alem U, Kajdacsy-Balla A, Wiley EL, Tonetti D (2015) Exploring DNA methylation changes in promoter, intragenic, and intergenic regions as early and late events in breast cancer formation. BMC Cancer 15:816","journal-title":"BMC Cancer"},{"key":"12482_CR80","doi-asserted-by":"publisher","first-page":"3224","DOI":"10.1158\/0008-5472.CAN-15-2249","volume":"76","author":"R Pathania","year":"2016","unstructured":"Pathania R, Ramachandran S, Mariappan G, Thakur P, Shi H, Choi J-H, Manicassamy S, Kolhe R, Prasad PD, Sharma S (2016) Combined inhibition of DNMT and HDAC blocks the tumorigenicity of cancer stem-like cells and attenuates mammary tumor growth. Cancer Res 76:3224\u20133235","journal-title":"Cancer Res"},{"key":"12482_CR81","first-page":"133","volume":"17","author":"S Khojastehpour","year":"2023","unstructured":"Khojastehpour S, Foroughi F, Gheibi N, Mohammadi Z, Ahmadi MH, Nasirian N, Maali A, Azad M (2023) The Association of Methylation Status and Expression Level of MyoD1 with DNMT1 Expression Level in Breast Cancer Patients. Int J Hematology-Oncology Stem Cell Res 17:133","journal-title":"Int J Hematology-Oncology Stem Cell Res"},{"key":"12482_CR82","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s13058-021-01453-4","volume":"23","author":"E Schaafsma","year":"2021","unstructured":"Schaafsma E, Zhang B, Schaafsma M, Tong C-Y, Zhang L, Cheng C (2021) Impact of Oncotype DX testing on ER+ breast cancer treatment and survival in the first decade of use. Breast Cancer Res 23:74","journal-title":"Breast Cancer Res"},{"key":"12482_CR83","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s12885-020-6534-z","volume":"20","author":"H Soliman","year":"2020","unstructured":"Soliman H, Shah V, Srkalovic G, Mahtani R, Levine E, Mavromatis B, Srinivasiah J, Kassar M, Gabordi R, Qamar R (2020) MammaPrint guides treatment decisions in breast Cancer: results of the IMPACt trial. BMC Cancer 20:81","journal-title":"BMC Cancer"},{"key":"12482_CR84","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41523-020-00208-2","volume":"7","author":"F Schettini","year":"2021","unstructured":"Schettini F, Chic N, Bras\u00f3-Maristany F, Par\u00e9 L, Pascual T, Conte B, Mart\u00ednez-S\u00e1ez O, Adamo B, Vidal M, Barnadas E (2021) Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer. NPJ Breast Cancer 7:1","journal-title":"NPJ Breast Cancer"},{"key":"12482_CR85","doi-asserted-by":"crossref","unstructured":"Vidal M, Peg V, Galv\u00e1n P, Tres A, Cort\u00e9s J; y, Cajal SR, Rubio IT, Prat A (2015) Gene expression-based classifications of fibroadenomas and phyllodes tumours of the breast. Molecular Oncology 9, 1081\u20131090","DOI":"10.1016\/j.molonc.2015.01.003"},{"key":"12482_CR86","first-page":"4249","volume":"37","author":"M Uhercik","year":"2017","unstructured":"Uhercik M, Sanders AJ, Owen S, Davies EL, Sharma AK, Jiang WG, Mokbel K (2017) Clinical significance of PD1 and PDL1 in human breast cancer. Anticancer Res 37:4249\u20134254","journal-title":"Anticancer Res"},{"key":"12482_CR87","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.3390\/cancers11071033","volume":"11","author":"G Planes-Laine","year":"2019","unstructured":"Planes-Laine G, Rochigneux P, Bertucci F, Chr\u00e9tien A-S, Viens P, Sabatier R, Gon\u00e7alves A (2019) PD-1\/PD-L1 targeting in breast cancer: the first clinical evidences are emerging\u2014a literature review. Cancers 11:1033","journal-title":"Cancers"},{"key":"12482_CR88","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3390\/cancers14020307","volume":"14","author":"M N\u00fa\u00f1ez Abad","year":"2022","unstructured":"N\u00fa\u00f1ez Abad M, Calabuig-Fari\u00f1as S, Lobo de Mena M, Torres-Mart\u00ednez S, Garc\u00eda Gonz\u00e1lez C, Garc\u00eda Garc\u00eda J\u00c1, Iranzo Gonz\u00e1lez-Cruz V (2022) Camps Herrero, C. Programmed death-ligand 1 (PD-L1) as immunotherapy biomarker in breast cancer. Cancers 14:307","journal-title":"Cancers"},{"key":"12482_CR89","doi-asserted-by":"publisher","first-page":"e12961","DOI":"10.1097\/MD.0000000000012961","volume":"97","author":"Y Deng","year":"2018","unstructured":"Deng Y, Zou J, Deng T, Liu J (2018) Clinicopathological and prognostic significance of GLUT1 in breast cancer: A meta-analysis. Medicine 97:e12961","journal-title":"Medicine"},{"key":"12482_CR90","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.breast.2016.08.014","volume":"30","author":"X Huang","year":"2016","unstructured":"Huang X, Li X, Xie X, Ye F, Chen B, Song C, Tang H, Xie X (2016) High expressions of LDHA and AMPK as prognostic biomarkers for breast cancer. Breast 30:39\u201346","journal-title":"Breast"},{"key":"12482_CR91","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3233\/BD-201035","volume":"40","author":"I Yustisia","year":"2021","unstructured":"Yustisia I, Amriani R, Cangara H, Syahrijuita S, Alfian Zainuddin A, Natsir R (2021) High expression of FBP1 and LDHB in fibroadenomas and invasive breast cancers. Breast Dis 40:251\u2013256","journal-title":"Breast Dis"},{"key":"12482_CR92","doi-asserted-by":"publisher","first-page":"e0199476","DOI":"10.1371\/journal.pone.0199476","volume":"13","author":"Z Chen","year":"2018","unstructured":"Chen Z, Ai L, Mboge MY, Tu C, McKenna R, Brown KD, Heldermon CD, Frost SC (2018) Differential expression and function of CAIX and CAXII in breast cancer: A comparison between tumorgraft models and cells. PLoS ONE 13:e0199476","journal-title":"PLoS ONE"},{"key":"12482_CR93","doi-asserted-by":"publisher","first-page":"7843","DOI":"10.3390\/ijms23147843","volume":"23","author":"S Addanki","year":"2022","unstructured":"Addanki S, Meas S, Sarli VN, Singh B, Lucci A (2022) Applications of circulating tumor cells and circulating tumor DNA in precision oncology for breast cancers. Int J Mol Sci 23:7843","journal-title":"Int J Mol Sci"},{"key":"12482_CR94","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1200\/PO.20.00345","volume":"5","author":"L Gerratana","year":"2021","unstructured":"Gerratana L, Davis AA, Zhang Q, Basile D, Rossi G, Strickland K, Franzoni A, Allegri L, Mu Z, Zhang Y (2021) Longitudinal dynamics of circulating tumor cells and circulating tumor DNA for treatment monitoring in metastatic breast cancer. JCO Precision Oncol 5:943\u2013952","journal-title":"JCO Precision Oncol"},{"key":"12482_CR95","doi-asserted-by":"publisher","first-page":"3341","DOI":"10.3390\/cancers14143341","volume":"14","author":"T Crook","year":"2022","unstructured":"Crook T, Leonard R, Mokbel K, Thompson A, Michell M, Page R, Vaid A, Mehrotra R, Ranade A, Limaye S (2022) Accurate screening for early-stage breast cancer by detection and profiling of circulating tumor cells. Cancers 14:3341","journal-title":"Cancers"},{"key":"12482_CR96","doi-asserted-by":"publisher","first-page":"942943","DOI":"10.3389\/fonc.2022.942943","volume":"12","author":"H Chen","year":"2022","unstructured":"Chen H, Li W, Wan C, Zhang J (2022) Correlation of dynamic contrast-enhanced MRI and diffusion-weighted MR imaging with prognostic factors and subtypes of breast cancers. Front Oncol 12:942943","journal-title":"Front Oncol"},{"key":"12482_CR97","doi-asserted-by":"crossref","unstructured":"Gao L, Li J, Gu Y, Ma L, Xu W, Tao X, Wang R, Zhang R, Zhang Y, Wang H (2022) Breast ultrasound in Chinese hospitals: A cross-sectional study of the current status and influencing factors of BI-RADS utilization and diagnostic accuracy. Lancet Reg Health\u2013Western Pac 29","DOI":"10.1016\/j.lanwpc.2022.100576"},{"key":"12482_CR98","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1038\/s41416-021-01459-x","volume":"125","author":"S Azam","year":"2021","unstructured":"Azam S, Eriksson M, Sj\u00f6lander A, Gabrielson M, Hellgren R, Czene K, Hall P (2021) Mammographic microcalcifications and risk of breast cancer. Br J Cancer 125:759\u2013765","journal-title":"Br J Cancer"},{"key":"12482_CR99","doi-asserted-by":"publisher","first-page":"e26745","DOI":"10.1097\/MD.0000000000026745","volume":"100","author":"M il Lee","year":"2021","unstructured":"il Lee M, Jung YJ, Kim DI, Lee S, Jung CS, Kang SK, Pak K, Kim SJ, Kim HY (2021) Prognostic value of SUVmax in breast cancer and comparative analyses of molecular subtypes: a systematic review and meta-analysis. Medicine 100:e26745","journal-title":"Medicine"},{"key":"12482_CR100","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/s41379-020-0583-3","volume":"34","author":"PH Tan","year":"2021","unstructured":"Tan PH (2021) Fibroepithelial lesions revisited: implications for diagnosis and management. Mod Pathol 34:15\u201337","journal-title":"Mod Pathol"},{"key":"12482_CR101","doi-asserted-by":"publisher","first-page":"e176749","DOI":"10.1172\/jci.insight.176749","volume":"10","author":"JR Eng","year":"2025","unstructured":"Eng JR, Bucher E, Hu Z, Walker CR, Risom T, Angelo M, Gonzalez-Ericsson P, Sanders ME, Chakravarthy AB, Pietenpol JA (2025) Highly multiplexed imaging reveals prognostic immune and stromal spatial biomarkers in breast cancer. JCI Insight 10:e176749","journal-title":"JCI Insight"},{"key":"12482_CR102","doi-asserted-by":"crossref","unstructured":"Huang Z, Wang H, Pang H, Zeng M, Zhang G, Liu F (2025) The comprehensive analysis of weighted gene Co-expression network analysis and machine learning revealed diagnostic biomarkers for breast implant illness complicated with breast cancer. Breast Cancer: Targets Therapy 305\u2013324","DOI":"10.2147\/BCTT.S507754"},{"key":"12482_CR103","first-page":"1","volume":"16","author":"EU Alum","year":"2025","unstructured":"Alum EU (2025) AI-driven biomarker discovery: enhancing precision in cancer diagnosis and prognosis. Discover Oncol 16:1\u201312","journal-title":"Discover Oncol"},{"key":"12482_CR104","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.trecan.2024.12.001","volume":"11","author":"M Ligero","year":"2025","unstructured":"Ligero M, El Nahhas OS, Aldea M, Kather JN (2025) Artificial intelligence-based biomarkers for treatment decisions in oncology. Trends Cancer 11:232\u2013244","journal-title":"Trends Cancer"},{"key":"12482_CR105","doi-asserted-by":"publisher","first-page":"4826","DOI":"10.1038\/s41598-024-83597-9","volume":"15","author":"S Zeng","year":"2025","unstructured":"Zeng S, Chen H, Jing R, Yang W, He L, Zou T, Liu P, Liang B, Shi D, Wu W (2025) An assessment of breast cancer HER2, ER, and PR expressions based on mammography using deep learning with convolutional neural networks. Sci Rep 15:4826","journal-title":"Sci Rep"},{"key":"12482_CR106","doi-asserted-by":"publisher","first-page":"24079","DOI":"10.1007\/s11042-024-20011-6","volume":"84","author":"AM Sharafaddini","year":"2025","unstructured":"Sharafaddini AM, Esfahani KK, Mansouri N (2025) Deep learning approaches to detect breast cancer: a comprehensive review. Multimedia Tools Appl 84:24079\u201324190","journal-title":"Multimedia Tools Appl"},{"key":"12482_CR107","doi-asserted-by":"crossref","unstructured":"Wu H, Zhang X-Y, Niu M, Li F-F, Gao S, Wei W et al (2020) Isobaric tags for relative and absolute quantitation in proteomic analysis of potential biomarkers in invasive cancer, ductal carcinoma in situ, and mammary fibroadenoma. Front Oncol ;10","DOI":"10.3389\/fonc.2020.574552"},{"key":"12482_CR108","doi-asserted-by":"crossref","unstructured":"Freitas AJ, Causin R, Varuzza MB, Calfa S, Hidalgo Filho CMT, Komoto T et al (2022) Liquid biopsy as a tool for the diagnosis, treatment, and monitoring of breast cancer. Int J Mol Sci ;23","DOI":"10.3390\/ijms23179952"},{"key":"12482_CR109","doi-asserted-by":"crossref","unstructured":"Lone SN, Nisar S, Masoodi TA, Singh M, Rizwan A, Hashem S et al (2022) Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments. Mol Cancer ;21","DOI":"10.1186\/s12943-022-01543-7"},{"key":"12482_CR110","doi-asserted-by":"crossref","unstructured":"Lee Y, Ni J, Beretov J, Wasinger V, Graham P, Li Y (2023) Recent advances of small extracellular vesicle biomarkers in breast cancer diagnosis and prognosis. Mol Cancer ;22","DOI":"10.1186\/s12943-023-01741-x"},{"key":"12482_CR111","doi-asserted-by":"crossref","unstructured":"Ma L, Guo H, Zhao Y, Liu Z, Wang C, Bu J et al (2024) Liquid biopsy in cancer: current status, challenges and future prospects. Signal Transduct Target Therapy ;9","DOI":"10.1038\/s41392-024-02021-w"},{"key":"12482_CR112","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Gonz\u00e1lez L, Sanchez Cendra A, S\u00e1nchez Cendra C, Roberts Cervantes ED, Cassinello Espinosa J, Pekarek T et al (2024) Exploring biomarkers in breast cancer: hallmarks of diagnosis, treatment, and follow-up in clinical practice. Medicina ;60","DOI":"10.3390\/medicina60010168"},{"key":"12482_CR113","doi-asserted-by":"crossref","unstructured":"Zakari S, Niels NK, Olagunju GV, Nnaji P, Ogunniyi OB, Tebamifor M et al (2024) Emerging biomarkers for non-invasive diagnosis and treatment of cancer: a systematic review. Front Oncol ;14","DOI":"10.3389\/fonc.2024.1405267"},{"key":"12482_CR114","doi-asserted-by":"crossref","unstructured":"Ho H-Y, Chung K-S, Kan C, Wong S (2024) Liquid biopsy in the clinical management of cancers. Int J Mol Sci ;25","DOI":"10.3390\/ijms25168594"},{"key":"12482_CR115","doi-asserted-by":"crossref","unstructured":"Sahin AA, Chen H, Xiao H, Senthil D, Meric-Bernstam F (2025) Emerging molecular therapeutic targets in breast cancer: pathologic identification and clinical implications. Hum Pathol 105881","DOI":"10.1016\/j.humpath.2025.105881"},{"key":"12482_CR116","doi-asserted-by":"crossref","unstructured":"Simancas-Racines D, Rom\u00e1n-Galeano N, V\u00e1squez JP, Jima Gavilanes D, Vijayan R, Reytor-Gonz\u00e1lez C (2025) Liquid biopsy and multi-omic biomarkers in breast cancer: innovations in early detection, therapy guidance, and disease monitoring. Biomedicines ;13","DOI":"10.3390\/biomedicines13123073"},{"key":"12482_CR117","unstructured":"Hsu W-W, Wu Y, Hao C, Hou Y-L, Gao X, Shao Y et al (2021) A computer-aided diagnosis system for breast pathology: a deep learning approach with model interpretability from pathological perspective"},{"key":"12482_CR118","unstructured":"Akbarnejad A, Ray N, Barnes PJ, Bigras G (2023) Predicting Ki67, ER, PR, and HER2 statuses from H&E-stained breast cancer images"},{"key":"12482_CR119","unstructured":"Jha SK, Mishra P, Mathur S, Singh G, Kumar R, Aatre K et al (2024) Development and validation of fully automatic deep learning-based algorithms for immunohistochemistry reporting of invasive breast ductal carcinoma"},{"key":"12482_CR120","doi-asserted-by":"crossref","unstructured":"Tareke TW, Payan N, Cochet A, Arnould L, Presles B, Vrigneaud J-M et al (2025) Automatic quantification of breast cancer biomarkers from multiple 18F-FDG PET image segmentation","DOI":"10.1038\/s41598-026-50945-w"},{"issue":"1","key":"12482_CR121","doi-asserted-by":"publisher","first-page":"26","DOI":"10.2174\/0115748928251754230922095544","volume":"20","author":"RA Reddy","year":"2025","unstructured":"Reddy RA, Varshini MS, Kumar RS (2025) Matrix metalloproteinase-2 (MMP-2): As an essential factor in cancer progression. Recent Pat Anti-cancer Drug Discov 20(1):26\u201344","journal-title":"Recent Pat Anti-cancer Drug Discov"},{"key":"12482_CR122","doi-asserted-by":"crossref","unstructured":"Ramala SR Jr, Chandak S, Chandak MS, Annareddy S, Annareddy Sr S (2023) A comprehensive review of breast fibroadenoma: correlating clinical and pathological findings. Cureus 15(12)","DOI":"10.7759\/cureus.49948"},{"issue":"7","key":"12482_CR123","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.3390\/cancers15071987","volume":"15","author":"MF Mercogliano","year":"2023","unstructured":"Mercogliano MF, Bruni S, Mauro FL, Schillaci R (2023) Emerging targeted therapies for HER2-positive breast cancer. Cancers 15(7):1987","journal-title":"Cancers"},{"issue":"1","key":"12482_CR124","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s12967-025-06495-2","volume":"23","author":"M Hum","year":"2025","unstructured":"Hum M, Lee AS (2025) DNA methylation in breast cancer: early detection and biomarker discovery through current and emerging approaches. J Translational Med 23(1):46","journal-title":"J Translational Med"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12482-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12482-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12482-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:05:42Z","timestamp":1785452742000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12482-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":124,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12482"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12482-7","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]},"assertion":[{"value":"3 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declaration"}}],"article-number":"1309"}}