{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:42:27Z","timestamp":1791996147335,"version":"4.4.0"},"reference-count":100,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"CAMS Innovation Fund for Medical Sciences","award":["(2021-I2M-1-030)"],"award-info":[{"award-number":["(2021-I2M-1-030)"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12516-0","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:45:14Z","timestamp":1785501914000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mechanisms and therapeutic potential of AMPK signaling pathway in the regulation of lipid metabolism"],"prefix":"10.1007","volume":"53","author":[{"given":"Xiaohong","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueling","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"issue":"1","key":"12516_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","volume":"15","author":"M YOUNOSSI Z, ANSTEE Q M, MARIETTI","year":"2018","unstructured":"Younossi Z, Anstee QM, Marietti M, Hardy T, Henry L, Eslam M, George J, Bugianesi E (2018) Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention [J]. Nat Rev Gastroenterol Hepatol 15(1):11\u201320","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"12516_CR2","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/S2468-1253(22)00317-X","volume":"8","author":"J QUEK","year":"2023","unstructured":"Quek J, Chan KE, Wong ZY, Tan C, Tan B, Lim WH, Tan DJH, Tang ASP, Tay P, Xiao J, Yong JN, Zeng RW, Chew NWS, Nah B, Kulkarni A, Siddiqui MS, Dan YY, Wong VW, Sanyal AJ, Noureddin M, Muthiah M, Ng CH (2023) Global prevalence of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in the overweight and obese population: a systematic review and meta-analysis [J]. Lancet Gastroenterol Hepatol 8(1):20\u201330","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"4","key":"12516_CR3","doi-asserted-by":"publisher","first-page":"e176347","DOI":"10.1172\/JCI176347","volume":"134","author":"IZ Jaffe","year":"2024","unstructured":"Jaffe IZ, Karumanchi SA (2024) Lipid droplets in the endothelium: The missing link between metabolic syndrome and cardiovascular disease? J Clin Invest 134(4):e176347","journal-title":"J Clin Invest"},{"issue":"18","key":"12516_CR4","doi-asserted-by":"publisher","first-page":"9885","DOI":"10.3390\/ijms22189885","volume":"22","author":"YM Kang","year":"2021","unstructured":"Kang YM, Kang HA, Cominguez DC, Kim SH, An HJ (2021) Papain Ameliorates Lipid Accumulation and Inflammation in High-Fat Diet-Induced Obesity Mice and 3T3-L1 Adipocytes via AMPK Activation. Int J Mol Sci 22(18):9885","journal-title":"Int J Mol Sci"},{"issue":"1","key":"12516_CR5","doi-asserted-by":"publisher","first-page":"453","DOI":"10.3390\/ijms25010453","volume":"25","author":"SA Hawley","year":"2023","unstructured":"Hawley SA, Russell FM, Ross FA, Hardie DG (2023) BAY-3827 and SBI-0206965: Potent AMPK Inhibitors That Paradoxically Increase Thr172 Phosphorylation. Int J Mol Sci 25(1):453","journal-title":"Int J Mol Sci"},{"issue":"2","key":"12516_CR6","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1042\/BJ20150910","volume":"473","author":"ROSS F A","year":"2016","unstructured":"Ross FA, Jensen TE, Hardie DG (2016) Differential regulation by AMP and ADP of AMPK complexes containing different \u03b3 subunit isoforms [J]. Biochem J 473(2):189\u2013199","journal-title":"Biochem J"},{"key":"12516_CR7","doi-asserted-by":"crossref","unstructured":"Mao Y, Cui M, Jiang Y et al (2025) AMPK\u03b12 signals amino acid insufficiency to inhibit protein synthesis [J]. Cell Metab","DOI":"10.1016\/j.cmet.2025.09.004"},{"issue":"7","key":"12516_CR8","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1161\/HYPERTENSIONAHA.125.24839","volume":"82","author":"H NIE","year":"2025","unstructured":"Nie H, Wang X (2025) Hyperlipidemia Triggers Trophoblast Cell Dysfunction and Preeclampsia via the AMPK\/GATA3\/FTL Pathway [J]. Hypertension 82(7):1221\u20131233","journal-title":"Hypertension"},{"key":"12516_CR9","doi-asserted-by":"publisher","first-page":"616520","DOI":"10.3389\/fcell.2021.616520","volume":"9","author":"D HEINZ","year":"2021","unstructured":"Heinz D, Krotova E, Hamann A et al (2021) Simultaneous Ablation of the Catalytic AMPK \u03b1-Subunit SNF1 and Mitochondrial Matrix Protease CLPP Results in Pronounced Lifespan Extension [J]. Front Cell Dev Biol 9:616520","journal-title":"Front Cell Dev Biol"},{"issue":"8","key":"12516_CR10","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1042\/BCJ20240082","volume":"481","author":"DG HAWLEY S A, RUSSELL F M, HARDIE","year":"2024","unstructured":"Hawley SA, Russell FM, Hardie DG (2024) AMP-activated protein kinase can be allosterically activated by ADP but AMP remains the key activating ligand [J]. Biochem J 481(8):587\u2013599","journal-title":"Biochem J"},{"issue":"9","key":"12516_CR11","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/s41419-019-1893-6","volume":"10","author":"L YING","year":"2019","unstructured":"Ying L, Li N, He Z et al (2019) Fibroblast growth factor 21 Ameliorates diabetes-induced endothelial dysfunction in mouse aorta via activation of the CaMKK2\/AMPK\u03b1 signaling pathway [J]. Cell Death Dis 10(9):665","journal-title":"Cell Death Dis"},{"issue":"22","key":"12516_CR12","doi-asserted-by":"publisher","first-page":"4721","DOI":"10.3390\/nu15224721","volume":"15","author":"D Nayyar","year":"2023","unstructured":"Nayyar D, Yan X, Xu G, Shi M, Garnham AP, Mathai ML, McAinch AJ (2023) Gynostemma Pentaphyllum Increases Exercise Performance and Alters Mitochondrial Respiration and AMPK in Healthy Males. Nutrients 15(22):4721","journal-title":"Nutrients"},{"key":"12516_CR13","doi-asserted-by":"crossref","unstructured":"Chen S, Li J, Liang Y et al (2024) \u03b2-catenin-inhibited Sumoylation modification of LKB1 and fatty acid metabolism is critical in renal fibrosis [J], vol 15. Cell Death & Disease, p 769. 10","DOI":"10.1038\/s41419-024-07154-y"},{"issue":"1","key":"12516_CR14","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s41419-025-07362-0","volume":"16","author":"W WANG","year":"2025","unstructured":"Wang W, Wu B, Hao M et al (2025) Positive feedback loop involving AMPK and CLYBL acetylation links metabolic rewiring and inflammatory responses [J]. Cell Death Dis 16(1):41","journal-title":"Cell Death Dis"},{"issue":"1","key":"12516_CR15","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1186\/s12967-023-04772-6","volume":"21","author":"Y CUI","year":"2023","unstructured":"Cui Y, Chen J, Zhang Z et al (2023) The role of AMPK in macrophage metabolism, function and polarisation [J]. J Transl Med 21(1):892","journal-title":"J Transl Med"},{"issue":"2","key":"12516_CR16","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/s42255-024-00984-2","volume":"6","author":"X ZHANG","year":"2024","unstructured":"Zhang X, Jeon G, Kapoor D (2024) Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk [J]. Nat Metab 6(2):359\u2013377","journal-title":"Nat Metab"},{"issue":"2","key":"12516_CR17","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/s42255-022-00732-4","volume":"5","author":"X DAI","year":"2023","unstructured":"Dai X, Jiang C, Jiang Q et al (2023) AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation [J]. Nat Metab 5(2):265\u2013276","journal-title":"Nat Metab"},{"issue":"12","key":"12516_CR18","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1080\/15548627.2025.2519054","volume":"21","author":"Y Jang","year":"2025","unstructured":"Jang Y, Ko M, Lee JY, Kim JY, Lee EW, Kwon HJ (2025) Inhibition of lysosomal LAMTOR1 increases autophagy by suppressing the MTORC1 pathway to ameliorate lipid accumulations in MAFLD. Autophagy 21(12):2633\u20132649","journal-title":"Autophagy"},{"issue":"7","key":"12516_CR19","doi-asserted-by":"publisher","first-page":"3046","DOI":"10.1002\/ptr.8518","volume":"39","author":"M SUN","year":"2025","unstructured":"Sun M, Zhong P, Xu G, Zeng W, Yu M, Cao J, Jin J, Chen J, Zhao Z (2025) 3-Oxo-22\u03b1-Hydroxy-Rotundic Acid Alleviates Hyperlipidemia in Mice by Modulating Lipid Metabolism Through the AMPK-SREBP-1c-PPAR\u03b1 Pathway [J]. Phytother Res 39(7):3046\u20133061","journal-title":"Phytother Res"},{"issue":"84","key":"12516_CR20","doi-asserted-by":"publisher","first-page":"eade7652","DOI":"10.1126\/sciimmunol.ade7652","volume":"8","author":"C BAIK S H, RAMANUJAN V K, BECKER","year":"2023","unstructured":"Baik SH, Ramanujan VK, Becker C, Fett S, Underhill DM, Wolf AJ (2023) Hexokinase dissociation from mitochondria promotes oligomerization of VDAC that facilitates NLRP3 inflammasome assembly and activation [J]. Sci Immunol 8(84):eade7652","journal-title":"Sci Immunol"},{"issue":"7","key":"12516_CR21","doi-asserted-by":"publisher","first-page":"997","DOI":"10.3390\/biom15070997","volume":"15","author":"X Yang","year":"2025","unstructured":"Yang X, Holliday LS (2025) V-ATPase and Lysosomal Energy Sensing in Periodontitis and Medicine-Related Osteonecrosis of the Jaw. Biomolecules 15(7):997","journal-title":"Biomolecules"},{"issue":"5","key":"12516_CR22","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1080\/15548627.2023.2287932","volume":"20","author":"Y XU","year":"2024","unstructured":"Xu Y, Qian C, Wang Q, Song L, He Z, Liu W, Wan W (2024) Deacetylation of ATG7 drives the induction of macroautophagy and LC3-associated microautophagy [J]. Autophagy 20(5):1134\u20131146","journal-title":"Autophagy"},{"issue":"6","key":"12516_CR23","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1042\/BCJ20250267","volume":"483","author":"A JHAWAR","year":"2026","unstructured":"Jhawar A, Parks K, Schmitt DL (2026) Illuminating compartmentalized AMPK signaling in single cells [J]. Biochem J 483(6):849\u2013860","journal-title":"Biochem J"},{"key":"12516_CR24","doi-asserted-by":"publisher","first-page":"154798","DOI":"10.1016\/j.metabol.2021.154798","volume":"120","author":"J YOO","year":"2021","unstructured":"Yoo J, Jeong IK, Ahn KJ, Chung HY, Hwang YC (2021) Fenofibrate, a PPAR\u03b1 agonist, reduces hepatic fat accumulation through the upregulation of TFEB-mediated lipophagy [J]. Metabolism 120:154798","journal-title":"Metabolism"},{"issue":"18","key":"12516_CR25","doi-asserted-by":"publisher","first-page":"9950","DOI":"10.3390\/ijms25189950","volume":"25","author":"V Padalko","year":"2024","unstructured":"Padalko V, Posnik F, Adamczyk M (2024) Mitochondrial Aconitase and Its Contribution to the Pathogenesis of Neurodegenerative Diseases. Int J Mol Sci 25(18):9950","journal-title":"Int J Mol Sci"},{"key":"12516_CR26","doi-asserted-by":"publisher","first-page":"156417","DOI":"10.1016\/j.metabol.2025.156417","volume":"174","author":"L LI","year":"2026","unstructured":"Li L, Wang Y, Du Z et al (2026) Hepatic aconitase 1 redirects citrate flux to suppress lipogenesis and ameliorate hypercholesterolemia [J]. Metabolism 174:156417","journal-title":"Metabolism"},{"issue":"7","key":"12516_CR27","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.3390\/nu16071003","volume":"16","author":"P Zabielski","year":"2024","unstructured":"Zabielski P, Imierska M, Roszczyc-Owsiejczuk K, Ku\u017amicki M, Rogalski P, Daniluk J, B\u0142achnio-Zabielska AU (2024) The Role of Acyl-CoA Synthetase 1 in Bioactive Lipid Accumulation and the Development of Hepatic Insulin Resistance. Nutrients 16(7):1003","journal-title":"Nutrients"},{"issue":"9","key":"12516_CR28","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1080\/15548627.2024.2355074","volume":"20","author":"D KAZYKEN","year":"2024","unstructured":"Kazyken D, Dame S G, Wang C et al (2024) Unexpected roles for AMPK in the suppression of autophagy and the reactivation of MTORC1 signaling during prolonged amino acid deprivation [J]. Autophagy 20(9):2017\u20132040","journal-title":"Autophagy"},{"issue":"12","key":"12516_CR29","doi-asserted-by":"publisher","first-page":"e2301164","DOI":"10.1002\/advs.202301164","volume":"11","author":"L ZHAO","year":"2024","unstructured":"Zhao L, Gao N, Peng X et al (2024) TRAF4-Mediated LAMTOR1 Ubiquitination Promotes mTORC1 Activation and Inhibits the Inflammation-Induced Colorectal Cancer Progression [J]. Adv Sci (Weinh) 11(12):e2301164","journal-title":"Adv Sci (Weinh)"},{"issue":"11","key":"12516_CR30","doi-asserted-by":"publisher","first-page":"e202308099","DOI":"10.1083\/jcb.202308099","volume":"223","author":"Y Huang","year":"2024","unstructured":"Huang Y, Luo G, Peng K, Song Y, Wang Y, Zhang H, Li J, Qiu X, Pu M, Liu X, Peng C, Neculai D, Sun Q, Zhou T, Huang P, Liu W (2024) Lactylation stabilizes TFEB to elevate autophagy and lysosomal activity. J Cell Biol 223(11):e202308099","journal-title":"J Cell Biol"},{"issue":"36","key":"12516_CR31","doi-asserted-by":"publisher","first-page":"e2404080","DOI":"10.1002\/advs.202404080","volume":"11","author":"H ZHANG","year":"2024","unstructured":"Zhang H, Ge G, Zhang W et al (2024) PP2Ac Regulates Autophagy via Mediating mTORC1 and ULK1 During Osteoclastogenesis in the Subchondral Bone of Osteoarthritis [J]. Adv Sci (Weinh) 11(36):e2404080","journal-title":"Adv Sci (Weinh)"},{"issue":"6590","key":"12516_CR32","doi-asserted-by":"publisher","first-page":"eabf8271","DOI":"10.1126\/science.abf8271","volume":"376","author":"WADAS GOSIS B S","year":"2022","unstructured":"Gosis BS, Wada S, Thorsheim C et al (2022) Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1 [J]. Science 376(6590):eabf8271","journal-title":"Science"},{"key":"12516_CR33","doi-asserted-by":"publisher","first-page":"113377","DOI":"10.1016\/j.biopha.2022.113377","volume":"153","author":"G HARLEY","year":"2022","unstructured":"Harley G, Katerelos M, Gleich K et al (2022) Blocking AMPK signalling to acetyl-CoA carboxylase increases cisplatin-induced acute kidney injury and suppresses the benefit of metformin [J]. Biomed Pharmacother 153:113377","journal-title":"Biomed Pharmacother"},{"issue":"11","key":"12516_CR34","doi-asserted-by":"publisher","first-page":"e111901","DOI":"10.15252\/embj.2022111901","volume":"42","author":"J NGO","year":"2023","unstructured":"Ngo J, Choi DW, Stanley IA et al (2023) Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA [J]. Embo j 42(11):e111901","journal-title":"Embo j"},{"issue":"7922","key":"12516_CR35","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/s41586-022-05006-3","volume":"608","author":"JQ WANG","year":"2022","unstructured":"Wang JQ, Li LL, Hu A et al (2022) Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion [J]. Nature 608(7922):413\u2013420","journal-title":"Nature"},{"issue":"5","key":"12516_CR36","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1158\/0008-5472.CAN-23-0555","volume":"84","author":"D AWAD","year":"2024","unstructured":"Awad D, Cao P HA, Pulliam TL et al (2024) Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity [J]. Cancer Res 84(5):703\u2013724","journal-title":"Cancer Res"},{"issue":"6642","key":"12516_CR37","doi-asserted-by":"publisher","first-page":"eabj5559","DOI":"10.1126\/science.abj5559","volume":"380","author":"N MALIK","year":"2023","unstructured":"Malik N, Ferreira BI, Hollsteinp E et al (2023) Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1 [J]. Science 380(6642):eabj5559","journal-title":"Science"},{"key":"12516_CR38","doi-asserted-by":"publisher","first-page":"114473","DOI":"10.1016\/j.biopha.2023.114473","volume":"161","author":"X WANG","year":"2023","unstructured":"Wang X (2023) Magnolol improves Alzheimer\u2019s disease-like pathologies and cognitive decline by promoting autophagy through activation of the AMPK\/mTOR\/ULK1 pathway [J]. Biomed Pharmacother 161:114473","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"12516_CR39","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41598-023-50903-w","volume":"14","author":"SONGYEKUTUE RAHMAN A A, BUTCKO A J","year":"2024","unstructured":"Rahman AA, Butcko AJ, Songyekutu E et al (2024) Direct effects of adipocyte lipolysis on AMPK through intracellular long-chain acyl-CoA signaling [J]. Sci Rep 14(1):19","journal-title":"Sci Rep"},{"issue":"8","key":"12516_CR40","doi-asserted-by":"publisher","first-page":"4047","DOI":"10.1016\/j.apsb.2025.05.015","volume":"15","author":"J LI","year":"2025","unstructured":"Li J, Wang M, Qu K et al (2025) IMM-H007 promotes hepatic cholesterol and triglyceride metabolism by activating AMPK\u03b1 to attenuate hypercholesterolemia [J]. Acta Pharm Sin B 15(8):4047\u20134063","journal-title":"Acta Pharm Sin B"},{"issue":"11","key":"12516_CR41","doi-asserted-by":"publisher","first-page":"108269","DOI":"10.1016\/j.isci.2023.108269","volume":"26","author":"S DAY E A, TOWNSEND L K, REHAL","year":"2023","unstructured":"Day E A, Townsend L K, Rehal S et al (2023) Macrophage AMPK \u03b21 activation by PF-06409577 reduces the inflammatory response, cholesterol synthesis, and atherosclerosis in mice [J]. iScience 26(11):108269","journal-title":"iScience"},{"key":"12516_CR42","doi-asserted-by":"publisher","first-page":"101514","DOI":"10.1016\/j.molmet.2022.101514","volume":"61","author":"X LEE M K S, COONEY O D, LIN","year":"2022","unstructured":"Lee MKS, Cooney OD, Lin X et al (2022) Defective AMPK regulation of cholesterol metabolism accelerates atherosclerosis by promoting HSPC mobilization and myelopoiesis [J]. Mol Metab 61:101514","journal-title":"Mol Metab"},{"key":"12516_CR43","doi-asserted-by":"publisher","first-page":"117608","DOI":"10.1016\/j.atherosclerosis.2024.117608","volume":"397","author":"P SMITH T K T, GHORBANI","year":"2024","unstructured":"Smith TKT, Ghorbani P, Leblond ND et al (2024) AMPK-mediated regulation of endogenous cholesterol synthesis does not affect atherosclerosis in a murine Pcsk9-AAV model [J]. Atherosclerosis 397:117608","journal-title":"Atherosclerosis"},{"key":"12516_CR44","doi-asserted-by":"publisher","first-page":"155271","DOI":"10.1016\/j.phymed.2023.155271","volume":"123","author":"C MENG","year":"2024","unstructured":"Meng C, Zhou L, Huang L et al (2024) Chlorogenic acid regulates the expression of NPC1L1 and HMGCR through PXR and SREBP2 signaling pathways and their interactions with HSP90 to maintain cholesterol homeostasis [J]. Phytomedicine 123:155271","journal-title":"Phytomedicine"},{"issue":"46","key":"12516_CR45","doi-asserted-by":"publisher","first-page":"17788","DOI":"10.1021\/acs.jafc.3c03559","volume":"71","author":"P NATRAJ","year":"2023","unstructured":"Natraj P, Rajan P, Jeon YA et al (2023) Antiadipogenic Effect of Citrus Flavonoids: Evidence from RNA Sequencing Analysis and Activation of AMPK in 3T3-L1 Adipocytes [J]. J Agric Food Chem 71(46):17788\u201317800","journal-title":"J Agric Food Chem"},{"key":"12516_CR46","doi-asserted-by":"publisher","first-page":"107478","DOI":"10.1016\/j.phrs.2024.107478","volume":"210","author":"M OLKOWICZ","year":"2024","unstructured":"Olkowicz M, Karas A, Berkowicz P et al (2024) Upregulation of ALOX12-12-HETE pathway impairs AMPK-dependent modulation of vascular metabolism in ApoE\/LDLR(-\/-) mice [J]. Pharmacol Res 210:107478","journal-title":"Pharmacol Res"},{"issue":"7","key":"12516_CR47","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1016\/j.cell.2024.02.024","volume":"187","author":"X Hu","year":"2024","unstructured":"Hu X, Chen F, Jia L, Long A, Peng Y, Li X, Huang J, Wei X, Fang X, Gao Z, Zhang M, Liu X, Chen YG, Wang Y, Zhang H, Wang Y (2024) A gut-derived hormone regulates cholesterol metabolism. Cell 187(7):1685\u20131700e18","journal-title":"Cell"},{"issue":"4","key":"12516_CR48","doi-asserted-by":"publisher","first-page":"619","DOI":"10.3390\/nu17040619","volume":"17","author":"H Gilliam-Vigh","year":"2025","unstructured":"Gilliam-Vigh H, Suppli MP, Heimb\u00fcrger SMN, Lund AB, Knop FK, Ellegaard AM (2025) Cholesin mRNA Expression in Human Intestinal, Liver, and Adipose Tissues. Nutrients 17(4):619","journal-title":"Nutrients"},{"issue":"1","key":"12516_CR49","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1186\/s12933-024-02322-y","volume":"23","author":"A RYK","year":"2024","unstructured":"Ryk A, Marcinkiewicz A, Chrzanowski J et al (2024) Cholesin receptor signalling is active in cardiovascular system-associated adipose tissue and correlates with SGLT2i treatment in patients with diabetes [J]. Cardiovasc Diabetol 23(1):211","journal-title":"Cardiovasc Diabetol"},{"issue":"13","key":"12516_CR50","doi-asserted-by":"publisher","first-page":"6061","DOI":"10.3390\/ijms26136061","volume":"26","author":"S Kim","year":"2025","unstructured":"Kim S, Baek J, Kim MS (2025) The Link Between Dietary Timing and Exercise Performance Through Adipocyte AMPK\u03b12 Signaling. Int J Mol Sci 26(13):6061","journal-title":"Int J Mol Sci"},{"issue":"5","key":"12516_CR51","doi-asserted-by":"publisher","first-page":"424","DOI":"10.3390\/vetsci12050424","volume":"12","author":"C Zhou","year":"2025","unstructured":"Zhou C, Chen H, Wu X, Dong H, Feng S, Tie Y, Zhao Z, Si L (2025) Mechanism of GBE Combined with TP on the Effect of AMPK\/SREBP-1C\/ACC Pathway on Lipid Metabolism in Heat-Stressed Broiler Liver. Vet Sci 12(5):424","journal-title":"Vet Sci"},{"key":"12516_CR52","doi-asserted-by":"publisher","first-page":"154561","DOI":"10.1016\/j.phymed.2022.154561","volume":"109","author":"B SHEN","year":"2023","unstructured":"Shen B, Wang Y, Cheng J et al (2023) Pterostilbene alleviated NAFLD via AMPK\/mTOR signaling pathways and autophagy by promoting Nrf2 [J]. Phytomedicine 109:154561","journal-title":"Phytomedicine"},{"issue":"775","key":"12516_CR53","doi-asserted-by":"publisher","first-page":"eadk0636","DOI":"10.1126\/scitranslmed.adk0636","volume":"16","author":"X JIAO","year":"2024","unstructured":"Jiao X, Li Y, Chen Z et al (2024) Targeting the PDE3B-cAMP-autophagy axis prevents liver injury in long-term supercooling liver preservation [J]. Sci Transl Med 16(775):eadk0636","journal-title":"Sci Transl Med"},{"key":"12516_CR54","doi-asserted-by":"publisher","first-page":"118165","DOI":"10.1016\/j.jep.2024.118165","volume":"329","author":"L YOU","year":"2024","unstructured":"You L, Wang T, Li W et al (2024) Xiaozhi formula attenuates non-alcoholic fatty liver disease by regulating lipid metabolism via activation of AMPK and PPAR pathways [J]. J Ethnopharmacol 329:118165","journal-title":"J Ethnopharmacol"},{"issue":"4","key":"12516_CR55","doi-asserted-by":"publisher","first-page":"716","DOI":"10.4093\/dmj.2023.0031","volume":"48","author":"SS LI","year":"2024","unstructured":"Li SS, Zhang ZY, Panl et al (2024) Diabetes Promotes Myocardial Fibrosis via AMPK\/EZH2\/PPAR-\u03b3 Signaling Pathway [J]. Diabetes Metab J 48(4):716\u2013729","journal-title":"Diabetes Metab J"},{"key":"12516_CR56","doi-asserted-by":"crossref","unstructured":"Chen S, Liu X, Peng C, Tan C, Sun H, Liu H, Zhang Y, Wu P, Cui C, Liu C, Yang D, Li Z, Lu J, Guan J, Ke X, Wang R, Bo X, Xu X, Han J, Liu J (2021) The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity. Cell Metab. ;33(3):565-580.e7","DOI":"10.1016\/j.cmet.2021.02.007"},{"key":"12516_CR57","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.semcdb.2022.05.016","volume":"143","author":"GURD B J","year":"2023","unstructured":"Gurd B J, Menezes ES, Arhen BB et al (2023) Impacts of altered exercise volume, intensity, and duration on the activation of AMPK and CaMKII and increases in PGC-1\u03b1 mRNA [J]. Semin Cell Dev Biol 143:17\u201327","journal-title":"Semin Cell Dev Biol"},{"issue":"5","key":"12516_CR58","doi-asserted-by":"publisher","first-page":"102089","DOI":"10.1016\/j.xcrm.2025.102089","volume":"6","author":"Y SU","year":"2025","unstructured":"Su Y, Sun J, Li X et al (2025) CD47-blocking antibody confers metabolic benefits against obesity [J]. Cell Rep Med 6(5):102089","journal-title":"Cell Rep Med"},{"key":"12516_CR59","doi-asserted-by":"crossref","unstructured":"Yang L, Liu L, Wang W et al (2025) Enhancer regulator MLL4 controls skeletal muscle metabolic efficiency by limiting AMPK-mediated fuel catabolism [J]. Nat Commun","DOI":"10.1038\/s41467-025-66684-x"},{"issue":"10","key":"12516_CR60","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1038\/s42255-024-01130-8","volume":"6","author":"P CARAPETO","year":"2024","unstructured":"Carapeto P, Iwasaki K, Hela F et al (2024) Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence [J]. Nat Metab 6(10):1976\u20131990","journal-title":"Nat Metab"},{"issue":"6","key":"12516_CR61","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1016\/j.cmet.2025.02.007","volume":"37","author":"J CHEN","year":"2025","unstructured":"Chen J, Xiang J, Zhou M et al (2025) Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPK\u03b12 signaling [J]. Cell Metab 37(6):1364\u201380e6","journal-title":"Cell Metab"},{"issue":"3","key":"12516_CR62","doi-asserted-by":"publisher","first-page":"e14103","DOI":"10.1111\/apha.14103","volume":"240","author":"H SHI","year":"2024","unstructured":"Shi H, Hao X, Sun Y et al (2024) Exercise-inducible circulating extracellular vesicle irisin promotes browning and the thermogenic program in white adipose tissue [J]. Acta Physiol (Oxf) 240(3):e14103","journal-title":"Acta Physiol (Oxf)"},{"issue":"8","key":"12516_CR63","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.3390\/ph18081222","volume":"18","author":"A Tero-Vescan","year":"2025","unstructured":"Tero-Vescan A, Degens H, Matsakas A, \u0218tef\u0103nescu R, \u0150sz BE, Slevin M (2025) Exercise-Induced Muscle-Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging. Pharmaceuticals (Basel) 18(8):1222","journal-title":"Pharmaceuticals (Basel)"},{"issue":"8023","key":"12516_CR64","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/s41586-024-07701-9","volume":"632","author":"VISWANATHANS WIDJAJA A A, LIM W W","year":"2024","unstructured":"Widjaja AA, Lim WW, viswanathan S et al (2024) Inhibition of IL-11 signalling extends mammalian healthspan and lifespan [J]. Nature 632(8023):157\u2013165","journal-title":"Nature"},{"issue":"7899","key":"12516_CR65","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/s41586-022-04431-8","volume":"603","author":"T MA","year":"2022","unstructured":"Ma T, Tian X, Zhang B et al (2022) Low-dose metformin targets the lysosomal AMPK pathway through PEN2 [J]. Nature 603(7899):159\u2013165","journal-title":"Nature"},{"issue":"4","key":"12516_CR66","doi-asserted-by":"publisher","first-page":"585","DOI":"10.3390\/biom12040585","volume":"12","author":"S Di Bini","year":"2022","unstructured":"Bini S, Pecce V, Di Costanzo A, Polito L, Ghadiri A, Minicocci I, Tambaro F, Covino S, Arca M, D'Erasmo L (2022) The Fibrinogen-like Domain of ANGPTL3 Facilitates Lipolysis in 3T3-L1 Cells by Activating the Intracellular Erk Pathway. Biomolecules 12(4):585","journal-title":"Biomolecules"},{"issue":"22","key":"12516_CR67","doi-asserted-by":"publisher","first-page":"4261","DOI":"10.1016\/j.molcel.2024.10.040","volume":"84","author":"JIANG H","year":"2024","unstructured":"Jiang H (2024) Balancing mitochondrial quality and quantity through opposite regulation of mitophagy pathways [J]. Mol Cell 84(22):4261\u20134263","journal-title":"Mol Cell"},{"issue":"10","key":"12516_CR68","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1038\/s41419-021-04184-8","volume":"12","author":"HAN Y C","year":"2021","unstructured":"Han YC, Tang SQ, Liu YT et al (2021) AMPK agonist alleviate renal tubulointerstitial fibrosis via activating mitophagy in high fat and streptozotocin induced diabetic mice [J]. Cell Death Dis 12(10):925","journal-title":"Cell Death Dis"},{"key":"12516_CR69","doi-asserted-by":"publisher","first-page":"114515","DOI":"10.1016\/j.biopha.2023.114515","volume":"161","author":"T JIN","year":"2023","unstructured":"Jin T, Zhang Y, Botchway BOA et al (2023) Quercetin activates the Sestrin2\/AMPK\/SIRT1 axis to improve amyotrophic lateral sclerosis [J]. Biomed Pharmacother 161:114515","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"12516_CR70","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41420-023-01331-2","volume":"9","author":"L WEI","year":"2023","unstructured":"Wei L, Chai S, Yue C et al (2023) Resveratrol protects osteocytes against oxidative stress in ovariectomized rats through AMPK\/JNK1-dependent pathway leading to promotion of autophagy and inhibition of apoptosis [J]. Cell Death Discov 9(1):16","journal-title":"Cell Death Discov"},{"key":"12516_CR71","doi-asserted-by":"publisher","first-page":"114613","DOI":"10.1016\/j.intimp.2025.114613","volume":"155","author":"Y HU","year":"2025","unstructured":"Hu Y, Chen X, Zhao Q et al (2025) Berberine improves cardiac insufficiency through AMPK\/PGC-1\u03b1 signaling-mediated mitochondrial homeostasis and apoptosis in HFpEF mice [J]. Int Immunopharmacol 155:114613","journal-title":"Int Immunopharmacol"},{"key":"12516_CR72","doi-asserted-by":"publisher","first-page":"116250","DOI":"10.1016\/j.bcp.2024.116250","volume":"225","author":"S ZHANG","year":"2024","unstructured":"Zhang S, Xie H, Pan P et al (2024) EGCG alleviates heat-stress-induced fat deposition by targeting HSP70 through activation of AMPK-SIRT1-PGC-1\u03b1 in porcine subcutaneous preadipocytes [J]. Biochem Pharmacol 225:116250","journal-title":"Biochem Pharmacol"},{"key":"12516_CR73","doi-asserted-by":"publisher","first-page":"113092","DOI":"10.1016\/j.biopha.2022.113092","volume":"151","author":"Z JIN","year":"2022","unstructured":"Jin Z, Chang B, Wei Y et al (2022) Curcumin exerts chondroprotective effects against osteoarthritis by promoting AMPK\/PINK1\/Parkin-mediated mitophagy [J]. Biomed Pharmacother 151:113092","journal-title":"Biomed Pharmacother"},{"issue":"23","key":"12516_CR74","doi-asserted-by":"publisher","first-page":"e70199","DOI":"10.1096\/fj.202401145RR","volume":"38","author":"C RAVEL-CHAPUIS A, FAHMI","year":"2024","unstructured":"Ravel-Chapuis A, Fahmi C, Gobin J et al (2024) The AMPK allosteric activator MK-8722 improves the histology and spliceopathy in myotonic dystrophy type 1 (DM1) skeletal muscle [J]. Faseb j 38(23):e70199","journal-title":"Faseb j"},{"issue":"1","key":"12516_CR75","doi-asserted-by":"publisher","first-page":"75","DOI":"10.7150\/thno.83051","volume":"14","author":"L WANG","year":"2024","unstructured":"Wang L, Zhu H, Shi Z et al (2024) MK8722 initiates early-stage autophagy while inhibiting late-stage autophagy via FASN-dependent reprogramming of lipid metabolism [J]. Theranostics 14(1):75\u201395","journal-title":"Theranostics"},{"issue":"10","key":"12516_CR76","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1038\/s42255-022-00640-7","volume":"4","author":"S ZHANG C","year":"2022","unstructured":"Zhang CS, Li M, Wang Y et al (2022) The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK [J]. Nat Metab 4(10):1369\u20131401","journal-title":"Nat Metab"},{"key":"12516_CR77","doi-asserted-by":"publisher","first-page":"116981","DOI":"10.1016\/j.biopha.2024.116981","volume":"180","author":"S BANG","year":"2024","unstructured":"Bang S, Kim DE, Kang HT et al (2024) Metformin restores autophagic flux and mitochondrial function in late passage myoblast to impede age-related muscle loss [J]. Biomed Pharmacother 180:116981","journal-title":"Biomed Pharmacother"},{"issue":"11","key":"12516_CR78","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/S2468-1253(21)00300-9","volume":"6","author":"K CUSI","year":"2021","unstructured":"Cusi K, Alkhouri N (2021) Efficacy and safety of PXL770, a direct AMP kinase activator, for the treatment of non-alcoholic fatty liver disease (STAMP-NAFLD): a randomised, double-blind, placebo-controlled, phase 2a study [J]. Lancet Gastroenterol Hepatol 6(11):889\u2013902","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"12","key":"12516_CR79","doi-asserted-by":"publisher","first-page":"100474","DOI":"10.1016\/j.xcrm.2021.100474","volume":"2","author":"P FOUQUERAY","year":"2021","unstructured":"Fouqueray P, Bolze S, Dubourg J et al (2021) Pharmacodynamic effects of direct AMP kinase activation in humans with insulin resistance and non-alcoholic fatty liver disease: A phase 1b study [J]. Cell Rep Med 2(12):100474","journal-title":"Cell Rep Med"},{"issue":"1","key":"12516_CR80","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1002\/hep4.1799","volume":"6","author":"FORETZM GLUAIS-DAGORN P","year":"2022","unstructured":"Gluais-Dagorn PF, Steinberg G R et al (2022) Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis [J]. Hepatol Commun 6(1):101\u2013119","journal-title":"Hepatol Commun"},{"issue":"4","key":"12516_CR81","doi-asserted-by":"publisher","first-page":"G433","DOI":"10.1152\/ajpgi.00337.2024","volume":"328","author":"I PATIL N Y, RUS","year":"2025","unstructured":"Patil NY, Rus I, Ampadu F et al (2025) Cinnabarinic acid protects against metabolic dysfunction-associated steatohepatitis by activating aryl hydrocarbon receptor-dependent AMPK signaling [J]. Am J Physiol Gastrointest Liver Physiol 328(4):G433\u2013g47","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"12516_CR82","doi-asserted-by":"publisher","first-page":"6567","DOI":"10.1038\/s41467-025-61963-z","volume":"16","author":"Z LI","year":"2025","unstructured":"Li Z, Tian Z, Shi X et al (2025) Adipose tissue-derived PRXL2A suppresses hepatic lipogenesis in a study with male mice [J]. Nat Commun 16(1):6567","journal-title":"Nat Commun"},{"issue":"7","key":"12516_CR83","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1080\/15548627.2021.1997051","volume":"18","author":"D BAI","year":"2022","unstructured":"Bai D, Du J, Bu X et al (2022) ALDOA maintains NLRP3 inflammasome activation by controlling AMPK activation [J]. Autophagy 18(7):1673\u20131693","journal-title":"Autophagy"},{"key":"12516_CR84","doi-asserted-by":"publisher","first-page":"155772","DOI":"10.1016\/j.metabol.2023.155772","volume":"152","author":"J JURADO-AGUILAR","year":"2024","unstructured":"Jurado-Aguilar J, Barroso E (2024) GDF15 activates AMPK and inhibits gluconeogenesis and fibrosis in the liver by attenuating the TGF-\u03b21\/SMAD3 pathway [J]. Metabolism 152:155772","journal-title":"Metabolism"},{"issue":"6","key":"12516_CR85","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1080\/15548627.2025.2466145","volume":"21","author":"M CHEN","year":"2025","unstructured":"Chen M, Liu G, Fang Z et al (2025) Buddleoside alleviates nonalcoholic steatohepatitis by targeting the AMPK-TFEB signaling pathway [J]. Autophagy 21(6):1316\u20131334","journal-title":"Autophagy"},{"issue":"7","key":"12516_CR86","doi-asserted-by":"publisher","first-page":"98852","DOI":"10.3748\/wjg.v31.i7.98852","volume":"31","author":"M TAO","year":"2025","unstructured":"Tao M, Zhang LL, Zhou GH et al (2025) Inhibition of metabotropic glutamate receptor-5 alleviates hepatic steatosis by enhancing autophagy via activation of the AMPK signaling pathway [J]. World J Gastroenterol 31(7):98852","journal-title":"World J Gastroenterol"},{"issue":"1","key":"12516_CR87","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/s10020-023-00721-7","volume":"29","author":"T GUO","year":"2023","unstructured":"Guo T, Yan W, Cui X et al (2023) Liraglutide attenuates type 2 diabetes mellitus-associated non-alcoholic fatty liver disease by activating AMPK\/ACC signaling and inhibiting ferroptosis [J]. Mol Med 29(1):132","journal-title":"Mol Med"},{"key":"12516_CR88","doi-asserted-by":"crossref","unstructured":"Guo M, Lin L, Wang Y et al (2026) DDR2 ameliorates nonalcoholic hepatic steatosis by activating the AMPK\/ACC pathway [J]. Scientific Reports","DOI":"10.1038\/s41598-026-42992-0"},{"key":"12516_CR89","doi-asserted-by":"publisher","first-page":"100032","DOI":"10.1074\/jbc.RA120.015420","volume":"296","author":"JQ WANG","year":"2021","unstructured":"Wang JQ, Lin Z C, Li LL et al (2021) SUMOylation of the ubiquitin ligase IDOL decreases LDL receptor levels and is reversed by SENP1 [J]. J Biol Chem 296:100032","journal-title":"J Biol Chem"},{"issue":"Pt A","key":"12516_CR90","doi-asserted-by":"publisher","first-page":"120269","DOI":"10.1016\/j.jep.2025.120269","volume":"353","author":"Q DONG","year":"2025","unstructured":"Dong Q, Wang Y, He Y et al (2025) Huaganjian decoction ameliorates metabolic dysfunction-associated steatotic liver disease through liver-gut crosstalk [J]. J Ethnopharmacol 353(Pt A):120269","journal-title":"J Ethnopharmacol"},{"issue":"15","key":"12516_CR91","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.3390\/cells13151291","volume":"13","author":"M Aslam","year":"2024","unstructured":"Aslam M, Li L, N\u00fcrnberger S, Niemann B, Rohrbach S (2024) CTRP13-Mediated Effects on Endothelial Cell Function and Their Potential Role in Obesity. Cells 13(15):1291","journal-title":"Cells"},{"issue":"Pt 4","key":"12516_CR92","doi-asserted-by":"publisher","first-page":"117503","DOI":"10.1016\/j.foodres.2025.117503","volume":"221","author":"D WU","year":"2025","unstructured":"Wu D, Hao M (2025) Dark tea extract extends Caenorhabditis elegans lifespan by enhancing antioxidant and ferroptosis resistance [J]. Food Res Int 221(Pt 4):117503","journal-title":"Food Res Int"},{"issue":"31","key":"12516_CR93","doi-asserted-by":"publisher","first-page":"e2409233121","DOI":"10.1073\/pnas.2409233121","volume":"121","author":"J GAO","year":"2024","unstructured":"Gao J, Liu CF, Liu PP et al (2024) Double-stranded RNA induces antiviral transcriptional response through the Dicer-2\/Ampk\/FoxO axis in an arthropod [J]. Proc Natl Acad Sci U S A 121(31):e2409233121","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12516_CR94","doi-asserted-by":"crossref","unstructured":"Xiao J, Wang S, Chen L, Ding X, Dang Y, Han M, Zheng Y, Shen H, Wu S, Wang M, Yang D, Li N, Dong C, Hu M, Su C, Li W, Hui L, Ye Y, Tang H, Wei B, Wang H (2024) 25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages. Immunity. ;57(5):1087-1104.e7","DOI":"10.1016\/j.immuni.2024.03.021"},{"issue":"24","key":"12516_CR95","doi-asserted-by":"publisher","first-page":"17280","DOI":"10.3390\/ijms242417280","volume":"24","author":"H Li","year":"2023","unstructured":"Li H, Wang M, Qu K, Xu R, Zhu H (2023) MP Allosterically Activates AMPK to Enhance ABCA1 Stability by Retarding the Calpain-Mediated Degradation Pathway. Int J Mol Sci 24(24):17280","journal-title":"Int J Mol Sci"},{"issue":"2","key":"12516_CR96","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1249\/JES.0000000000000333","volume":"52","author":"RG JONES","year":"2024","unstructured":"Jones RG 3rd, von Walden F, Murach KA (2024) Exercise-Induced MYC as an Epigenetic Reprogramming Factor That Combats Skeletal Muscle Aging [J]. Exerc Sport Sci Rev 52(2):63\u201367","journal-title":"Exerc Sport Sci Rev"},{"issue":"7","key":"12516_CR97","doi-asserted-by":"publisher","first-page":"e179990","DOI":"10.1172\/jci.insight.179990","volume":"10","author":"E Holm","year":"2025","unstructured":"Holm E, Vermeulen I, Parween S, L\u00f3pez-P\u00e9rez A, Cillero-Pastor B, Vandenbosch M, Remeseiro S, H\u00f6rnblad A (2025) AMPK activator ATX-304 reduces oxidative stress and improves MASLD via metabolic switching. JCI Insight 10(7):e179990","journal-title":"JCI Insight"},{"issue":"3","key":"12516_CR98","doi-asserted-by":"publisher","first-page":"2464","DOI":"10.3390\/ijms24032464","volume":"24","author":"G Tavares","year":"2023","unstructured":"Tavares G, Rosendo-Silva D, Sim\u00f5es F, Eickhoff H, Marques D, Sacramento JF, Capucho AM, Sei\u00e7a R, Conde SV, Matafome P (2023) Circulating Dopamine Is Regulated by Dietary Glucose and Controls Glucagon-like 1 Peptide Action in White Adipose Tissue. Int J Mol Sci 24(3):2464","journal-title":"Int J Mol Sci"},{"issue":"2","key":"12516_CR99","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.kint.2021.10.028","volume":"101","author":"H MA","year":"2022","unstructured":"Ma H, Guo X (2022) Dephosphorylation of AMP-activated protein kinase exacerbates ischemia\/reperfusion-induced acute kidney injury via mitochondrial dysfunction [J]. Kidney Int 101(2):315\u2013330","journal-title":"Kidney Int"},{"issue":"20","key":"12516_CR100","first-page":"11152","volume":"15","author":"J XU","year":"2023","unstructured":"Xu J, Chen P, Wu D et al (2023) The novel GLP-1\/GIP dual agonist DA3-CH improves rat type 2 diabetes through activating AMPK\/ACC signaling pathway [J]. Aging 15(20):11152\u201311161","journal-title":"Aging"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12516-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12516-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12516-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:02:42Z","timestamp":1785506562000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12516-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":100,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12516"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12516-0","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]},"assertion":[{"value":"12 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This manuscript is a review article and does not report original research involving human participants, human data, or animal experiments. Therefore, ethics approval and consent to participate are not applicable.","order":2,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1319"}}