{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:12:54Z","timestamp":1786122774843,"version":"build-2736575974"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12548-6","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T12:09:52Z","timestamp":1786104592000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Honeybee venom modulates antioxidant gene expression and tissue regeneration in a rat model of staphylococcus aureus - infected skin wounds"],"prefix":"10.1007","volume":"53","author":[{"given":"Sabir Ahmed","family":"Smael","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Treefa Farouq","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banaz Sdiq","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebwar Muhammad","family":"Hamasalih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esmat","family":"Khaleqsefat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azheen Subhi","family":"Abdulrahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramyar Hassan","family":"Mahmud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abubakr Mohammed","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozi Braim","family":"Abdalrahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1725-1730","authenticated-orcid":false,"given":"Harem Khdir","family":"Awla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"issue":"2","key":"12548_CR1","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s00281-011-0292-6","volume":"34","author":"S Krishna","year":"2012","unstructured":"Krishna S, Miller LS (2012) Innate and adaptive immune responses against Staphylococcus aureus skin infections. Semin Immunopathol 34(2):261\u2013280","journal-title":"Semin Immunopathol"},{"key":"12548_CR2","doi-asserted-by":"crossref","unstructured":"Simonetti O et al (2021) New Perspectives on Old and New Therapies of Staphylococcal Skin Infections: The Role of Biofilm Targeting in Wound Healing. Antibiot (Basel), 10(11)","DOI":"10.3390\/antibiotics10111377"},{"issue":"1\u20132","key":"12548_CR3","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/iep.12346","volume":"101","author":"DS Masson-Meyers","year":"2020","unstructured":"Masson-Meyers DS et al (2020) Experimental models and methods for cutaneous wound healing assessment. Int J Exp Pathol 101(1\u20132):21\u201337","journal-title":"Int J Exp Pathol"},{"issue":"8","key":"12548_CR4","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.2741\/4869","volume":"25","author":"KB Dickson","year":"2020","unstructured":"Dickson KB, Zhou J (2020) Role of reactive oxygen species and iron in host defense against infection. Front Biosci (Landmark Ed) 25(8):1600\u20131616","journal-title":"Front Biosci (Landmark Ed)"},{"key":"12548_CR5","doi-asserted-by":"publisher","first-page":"114004","DOI":"10.1016\/j.biopha.2022.114004","volume":"157","author":"G Wang","year":"2023","unstructured":"Wang G et al (2023) The initiation of oxidative stress and therapeutic strategies in wound healing. Biomed Pharmacother 157:114004","journal-title":"Biomed Pharmacother"},{"key":"12548_CR6","doi-asserted-by":"crossref","unstructured":"Espinosa-Ru\u00edz C, Esteban M Wound-induced changes in antioxidant enzyme activities in skin mucus and in gene expression in the skin of gilthead seabream (Sparus aurata L.), Fishes. 6 (2021) 15","DOI":"10.3390\/fishes6020015"},{"issue":"4","key":"12548_CR7","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ajme.2017.09.001","volume":"54","author":"O Ighodaro","year":"2018","unstructured":"Ighodaro O, Akinloye O (2018) First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alexandria J Med 54(4):287\u2013293","journal-title":"Alexandria J Med"},{"issue":"1","key":"12548_CR8","doi-asserted-by":"publisher","first-page":"7","DOI":"10.21315\/mjms2023.30.1.2","volume":"30","author":"J Md Jaffri","year":"2023","unstructured":"Md Jaffri J (2023) Reactive Oxygen Species and Antioxidant System in Selected Skin Disorders. Malays J Med Sci 30(1):7\u201320","journal-title":"Malays J Med Sci"},{"key":"12548_CR9","doi-asserted-by":"crossref","unstructured":"Moses RL et al (2023) Evidence for Natural Products as Alternative Wound-Healing Therapies. Biomolecules, 13(3)","DOI":"10.3390\/biom13030444"},{"key":"12548_CR10","doi-asserted-by":"crossref","unstructured":"Criollo-Mendoza MS et al (2023) Wound Healing Properties of Natural Products: Mechanisms of Action. Molecules, 28(2)","DOI":"10.3390\/molecules28020598"},{"key":"12548_CR11","doi-asserted-by":"crossref","unstructured":"Ratajczak M et al (2021) Promising Antimicrobial Properties of Bioactive Compounds from Different Honeybee Products. Molecules, 26(13)","DOI":"10.3390\/molecules26134007"},{"key":"12548_CR12","doi-asserted-by":"publisher","first-page":"e286731","DOI":"10.1590\/1519-6984.286731","volume":"84","author":"M Obeidat","year":"2024","unstructured":"Obeidat M, Haddad MA, Ghnamat SA (2024) Antimicrobial activities of seasonally collected bee products: honey, propolis, royal jelly, venom, and mellitin. Braz J Biol 84:e286731","journal-title":"Braz J Biol"},{"issue":"6","key":"12548_CR13","doi-asserted-by":"publisher","first-page":"103869","DOI":"10.1016\/j.arabjc.2022.103869","volume":"15","author":"AS Abdelsattar","year":"2022","unstructured":"Abdelsattar AS et al (2022) Enhancement of wound healing via topical application of natural products: in vitro and in vivo evaluations. Arab J Chem 15(6):103869","journal-title":"Arab J Chem"},{"issue":"4","key":"12548_CR14","doi-asserted-by":"publisher","first-page":"750","DOI":"10.3390\/pharmaceutics14040750","volume":"14","author":"CD Dumitru","year":"2022","unstructured":"Dumitru CD et al (2022) Bee-derived products: chemical composition and applications in skin tissue engineering. Pharmaceutics 14(4):750","journal-title":"Pharmaceutics"},{"issue":"2","key":"12548_CR15","doi-asserted-by":"publisher","first-page":"71","DOI":"10.18311\/jnr\/2020\/24172","volume":"20","author":"M Wadi","year":"2020","unstructured":"Wadi M, Geregandi T (2020) Efficacy of bee honey on wound healing: split skin graft with hyper-granulation tissue. J Nat Remedies 20(2):71\u201378","journal-title":"J Nat Remedies"},{"issue":"1","key":"12548_CR16","doi-asserted-by":"publisher","first-page":"16","DOI":"10.2174\/0122115501343962241121190220","volume":"14","author":"KJS Silva","year":"2025","unstructured":"Silva KJS et al (2025) Study of Brazilian Amazon Honeybees\u2018(Melipona scutellaris and Apis mellifera) Properties in Healing Infected Skin Wounds in Wistar Rats. Curr Biotechnol 14(1):16\u201328","journal-title":"Curr Biotechnol"},{"key":"12548_CR17","doi-asserted-by":"crossref","unstructured":"Bae S et al (2022) Therapeutic Effect of Bee Venom and Melittin on Skin Infection Caused by Streptococcus pyogenes. Toxins (Basel), 14(10)","DOI":"10.3390\/toxins14100663"},{"issue":"23","key":"12548_CR18","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1089\/scd.2021.0124","volume":"30","author":"M van de Vyver","year":"2021","unstructured":"van de Vyver M et al (2021) Histology Scoring System for Murine Cutaneous Wounds. Stem Cells Dev 30(23):1141\u20131152","journal-title":"Stem Cells Dev"},{"issue":"2","key":"12548_CR19","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s13201-023-02077-z","volume":"14","author":"M El-Adl","year":"2024","unstructured":"El-Adl M et al (2024) The efficiency of zinc sulfate immersion bath on improved wound healing via promoting antioxidant activity, gene expression biomarkers, and skin re-epithelization in a common carp-induced wound model. Appl Water Sci 14(2):31","journal-title":"Appl Water Sci"},{"issue":"1","key":"12548_CR20","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1007\/s10753-025-02415-0","volume":"49","author":"HK Mustafa","year":"2025","unstructured":"Mustafa HK et al (2025) L-Carnitine Attenuates Testicular Dysfunction in Type 1 Diabetes Mellitus Via Modulation of Oxidative Stress, Inflammation, and miRNA Expression. Inflammation 49(1):8","journal-title":"Inflammation"},{"issue":"1","key":"12548_CR21","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1007\/s11033-025-11059-0","volume":"52","author":"AA Bahjat","year":"2025","unstructured":"Bahjat AA, Rasul KH (2025) Novel and recurrent mutations in exon 8 of natural killer group 2D (NKG2D) gene among chronic myeloid leukemia patients and their potential role in pathogenesis. Mol Biol Rep 52(1):941","journal-title":"Mol Biol Rep"},{"key":"12548_CR22","doi-asserted-by":"crossref","unstructured":"Abdalrahman BR et al (2026) Protective effects of silymarin against favipiravir-induced renal injury in rats; a biochemical, histopathological, and immunohistochemical study. J Ren Injury Prev, 15(2)","DOI":"10.34172\/jrip.2026.38718"},{"key":"12548_CR23","doi-asserted-by":"crossref","unstructured":"Bastos MLC et al (2025) What Do We Know About Staphylococcus aureus and Oxidative Stress? Resistance, Virulence, New Targets, and Therapeutic Alternatives. Toxics, 13(5)","DOI":"10.3390\/toxics13050390"},{"issue":"3","key":"12548_CR24","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1002\/jat.70048","volume":"46","author":"M Mheich","year":"2026","unstructured":"Mheich M et al (2026) Recent Advances in the Antioxidant and Anti-Inflammatory Effects of Bee Venom: Therapeutic Insights and Mechanisms. J Appl Toxicol 46(3):808\u2013820","journal-title":"J Appl Toxicol"},{"issue":"1","key":"12548_CR25","doi-asserted-by":"publisher","first-page":"e2026009","DOI":"10.5620\/eaht.2026009","volume":"41","author":"F Dahdouh","year":"2026","unstructured":"Dahdouh F et al (2026) Algerian bee Venom attenuates formaldehyde-induced acute inflammation and oxidative stress in male rats. Environ Anal Health Toxicol 41(1):e2026009","journal-title":"Environ Anal Health Toxicol"},{"issue":"10","key":"12548_CR26","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1080\/15548627.2023.2218764","volume":"19","author":"Y Xie","year":"2023","unstructured":"Xie Y et al (2023) GPX4 in cell death, autophagy, and disease. Autophagy 19(10):2621\u20132638","journal-title":"Autophagy"},{"issue":"3","key":"12548_CR27","doi-asserted-by":"publisher","first-page":"100020","DOI":"10.1016\/j.brci.2025.100020","volume":"1","author":"D Stephenson","year":"2025","unstructured":"Stephenson D et al (2025) GPX4 regulates lipid peroxidation and ferroptosis of stored red blood cells. Blood Red Cells Iron 1(3):100020","journal-title":"Blood Red Cells Iron"},{"key":"12548_CR28","doi-asserted-by":"publisher","first-page":"1525529","DOI":"10.3389\/fphar.2025.1525529","volume":"16","author":"D Abdelrahaman","year":"2025","unstructured":"Abdelrahaman D et al (2025) Bee venom ameliorates gentamicin-induced kidney injury by restoring renal aquaporins and enhancing antioxidant and anti-inflammatory activities in rats. Front Pharmacol 16:1525529","journal-title":"Front Pharmacol"},{"key":"12548_CR29","doi-asserted-by":"crossref","unstructured":"Kurek-G\u00f3recka A et al (2020) Bee Venom in Wound Healing. Molecules, 26(1)","DOI":"10.3390\/molecules26010148"},{"issue":"1","key":"12548_CR30","doi-asserted-by":"publisher","first-page":"2656","DOI":"10.1038\/s41598-022-05979-1","volume":"12","author":"EK El Adham","year":"2022","unstructured":"El Adham EK, Hassan AI, MM AD (2022) Evaluating the role of propolis and bee venom on the oxidative stress induced by gamma rays in rats. Sci Rep 12(1):2656","journal-title":"Sci Rep"},{"issue":"1","key":"12548_CR31","first-page":"82","volume":"11","author":"A Elhanafy","year":"2023","unstructured":"Elhanafy A, Mousa A, Kamal A (2023) Immunomodulatory, anti-inflammatory and antioxidant activities of bee venom in doe rabbits under high ambient temperature. J Anim Health Prod 11(1):82\u201389","journal-title":"J Anim Health Prod"},{"issue":"2","key":"12548_CR32","doi-asserted-by":"publisher","first-page":"rbab003","DOI":"10.1093\/rb\/rbab003","volume":"8","author":"B Qian","year":"2021","unstructured":"Qian B et al (2021) Antioxidant biocompatible composite collagen dressing for diabetic wound healing in rat model. Regen Biomater 8(2):rbab003","journal-title":"Regen Biomater"},{"key":"12548_CR33","doi-asserted-by":"crossref","unstructured":"Md S et al (2022) Development and Evaluation of Ginkgo biloba\/Sodium Alginate Nanocomplex Gel as a Long-Acting Formulation for Wound Healing. Gels, 8(3)","DOI":"10.3390\/gels8030189"},{"key":"12548_CR34","doi-asserted-by":"crossref","unstructured":"Dumitru CD et al (2022) Bee-Derived Products: Chemical Composition and Applications in Skin Tissue Engineering. Pharmaceutics, 14(4)","DOI":"10.3390\/pharmaceutics14040750"},{"key":"12548_CR35","doi-asserted-by":"crossref","unstructured":"Kolimi P et al (2022) Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements. Cells, 11(15)","DOI":"10.3390\/cells11152439"},{"issue":"10","key":"12548_CR36","doi-asserted-by":"publisher","first-page":"e2105152","DOI":"10.1002\/advs.202105152","volume":"9","author":"R Li","year":"2022","unstructured":"Li R et al (2022) Bioactive Materials Promote Wound Healing through Modulation of Cell Behaviors. Adv Sci (Weinh) 9(10):e2105152","journal-title":"Adv Sci (Weinh)"},{"issue":"4","key":"12548_CR37","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/j.aspen.2019.09.001","volume":"22","author":"Y Yousefpoor","year":"2019","unstructured":"Yousefpoor Y et al (2019) Assessment of hemolytic activity of bee venom against some physicochemical factors. J Asia Pac Entomol 22(4):1129\u20131135","journal-title":"J Asia Pac Entomol"},{"issue":"4","key":"12548_CR38","doi-asserted-by":"publisher","first-page":"379","DOI":"10.3831\/KPI.2025.28.4.379","volume":"28","author":"F Dahdouh","year":"2025","unstructured":"Dahdouh F et al (2025) Therapeutic Potential of Bee Venom (Apis mellifera intermissa) in Reversing Aniline-Induced Acute Anaemia and Spleen Oxidative Damage in Mice. J Pharmacopunct 28(4):379\u2013385","journal-title":"J Pharmacopunct"},{"issue":"168","key":"12548_CR39","doi-asserted-by":"publisher","first-page":"32","DOI":"10.21608\/avmj.2021.177845","volume":"67","author":"A Marei","year":"2021","unstructured":"Marei A (2021) Effect of honeybee venom (Apis mellifera) on respiratory functions of hypercholesterolemic male albino rats. Assiut Veterinary Med J 67(168):32\u201342","journal-title":"Assiut Veterinary Med J"},{"issue":"6","key":"12548_CR40","first-page":"5091","volume":"15","author":"MY Hanafi","year":"2018","unstructured":"Hanafi MY et al (2018) The therapeutic effects of bee venom on some metabolic and antioxidant parameters associated with HFD-induced non-alcoholic fatty liver in rats. Exp Ther Med 15(6):5091\u20135099","journal-title":"Exp Ther Med"},{"issue":"5","key":"12548_CR41","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1093\/toxres\/tfaa077","volume":"9","author":"NM Meligi","year":"2020","unstructured":"Meligi NM, Ismail SA, Tawfik NS (2020) Protective effects of honey and bee venom against lipopolysaccharide and carbon tetrachloride-induced hepatoxicity and lipid peroxidation in rats. Toxicol Res (Camb) 9(5):693\u2013705","journal-title":"Toxicol Res (Camb)"},{"issue":"5","key":"12548_CR42","first-page":"2618","volume":"25","author":"H Mahdi","year":"2021","unstructured":"Mahdi H, Ibraheem RK (2021) Effect of bee venom on some physiological parameters in albino rabbits. Annals Romanian Soc Cell Biology 25(5):2618\u20132622","journal-title":"Annals Romanian Soc Cell Biology"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12548-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12548-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12548-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T12:09:55Z","timestamp":1786104595000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12548-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,7]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12548"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12548-6","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,7]]},"assertion":[{"value":"23 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1358"}}