{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:29:21Z","timestamp":1786364961947,"version":"build-2736575974"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82070282"],"award-info":[{"award-number":["No. 82070282"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["No. 2022MD723777"],"award-info":[{"award-number":["No. 2022MD723777"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"General Projects of Key Research and Development Plan in Shaanxi Province","award":["No. 2023-YBSF-346"],"award-info":[{"award-number":["No. 2023-YBSF-346"]}]},{"name":"Tianchi Talent Program (3rd) of Xinjiang Uygur Autonomous Region (Young Doctoral Talent)."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12556-6","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T11:41:40Z","timestamp":1786362100000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MicroRNA-223-3p\/NLRP3 axis attenuates LPS-induced sepsis-like myocardial dysfunction by suppressing cardiomyocyte pyroptosis"],"prefix":"10.1007","volume":"53","author":[{"given":"Bixue","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanliang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurbiya","family":"Aji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaikai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"issue":"8","key":"12556_CR1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M et al (2016) The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315(8):801\u2013810. https:\/\/doi.org\/10.1001\/jama.2016.0287","journal-title":"JAMA"},{"key":"12556_CR2","doi-asserted-by":"publisher","unstructured":"Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR et al (2020) Global, regional, and national sepsis incidence and mortality, 1990\u20132017: analysis for the Global Burden of Disease Study. Lancet ;395(10219):200\u2009\u2013\u200911. https:\/\/doi.org\/10.1016\/S0140-6736(19)32989-7","DOI":"10.1016\/S0140-6736(19)32989-7"},{"issue":"1","key":"12556_CR3","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s13613-022-01089-3","volume":"12","author":"YM Lin","year":"2022","unstructured":"Lin YM, Lee MC, Toh HS, Chang WT, Chen SY, Kuo FH et al (2022) Association of sepsis-induced cardiomyopathy and mortality: a systematic review and meta-analysis. Ann Intensive Care 12(1):112. https:\/\/doi.org\/10.1186\/s13613-022-01089-3","journal-title":"ANN INTENSIVE CARE"},{"issue":"4","key":"12556_CR4","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1097\/CCM.0000000000002851","volume":"46","author":"SJ Beesley","year":"2018","unstructured":"Beesley SJ, Weber G, Sarge T, Nikravan S, Grissom CK, Lanspa MJ et al (2018) Septic Cardiomyopathy. Crit Care Med 46(4):625\u2013634. https:\/\/doi.org\/10.1097\/CCM.0000000000002851","journal-title":"CRIT CARE MED"},{"key":"12556_CR5","doi-asserted-by":"publisher","first-page":"1805393","DOI":"10.3389\/fcvm.2026.1805393","volume":"13","author":"J Zhang","year":"2026","unstructured":"Zhang J, Sheng S, Luo W, Zhang Z (2026) Therapeutical progress in sepsis-induced cardiomyopathy. Front Cardiovasc Med 13:1805393. https:\/\/doi.org\/10.3389\/fcvm.2026.1805393","journal-title":"Front Cardiovasc Med"},{"key":"12556_CR6","doi-asserted-by":"publisher","first-page":"203","DOI":"10.3389\/fphar.2020.00203","volume":"11","author":"J Zhang","year":"2020","unstructured":"Zhang J, Wang M, Ye J, Liu J, Xu Y, Wang Z et al (2020) The anti-inflammatory mediator resolvin E1 protects mice against lipopolysaccharide-induced heart injury. Front Pharmacol 11:203. https:\/\/doi.org\/10.3389\/fphar.2020.00203","journal-title":"FRONT PHARMACOL"},{"issue":"6","key":"12556_CR7","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1002\/jcsm.12763","volume":"12","author":"K Busch","year":"2021","unstructured":"Busch K, Kny M, Huang N, Klassert TE, Stock M, Hahn A et al (2021) Inhibition of the NLRP3\/IL-1\u03b2 axis protects against sepsis-induced cardiomyopathy. J Cachexia Sarcopenia Muscle 12(6):1653\u20131668. https:\/\/doi.org\/10.1002\/jcsm.12763","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"4","key":"12556_CR8","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/s41569-023-00946-3","volume":"21","author":"S Toldo","year":"2024","unstructured":"Toldo S, Abbate A (2024) The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases. Nat Rev Cardiol 21(4):219\u2013237. https:\/\/doi.org\/10.1038\/s41569-023-00946-3","journal-title":"NAT REV CARDIOL"},{"key":"12556_CR9","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.2147\/DDDT.S506537","volume":"19","author":"Y Jin","year":"2025","unstructured":"Jin Y, Fleishman JS, Ma Y, Jing X, Guo Q, Shang W et al (2025) NLRP3 inflammasome targeting offers a novel therapeutic paradigm for sepsis-induced myocardial injury. Drug Des Devel Ther 19:1025\u20131041. https:\/\/doi.org\/10.2147\/DDDT.S506537","journal-title":"Drug Des Devel Ther"},{"key":"12556_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-025-01229-9","author":"T Sallam","year":"2026","unstructured":"Sallam T, van Solingen C, Moore KJ (2026) Non-coding RNAs in lipid metabolism and their roles in atherosclerosis. Nat Rev Cardiol. https:\/\/doi.org\/10.1038\/s41569-025-01229-9","journal-title":"NAT REV CARDIOL"},{"key":"12556_CR11","doi-asserted-by":"publisher","first-page":"546243","DOI":"10.2147\/JIR.S546243","volume":"19","author":"T Khuanjing","year":"2026","unstructured":"Khuanjing T, Chattipakorn SC, Chattipakorn N (2026) Emerging targets and treatments for doxorubicin-induced cardiac inflammation. J Inflamm Res 19:546243. https:\/\/doi.org\/10.2147\/JIR.S546243","journal-title":"J Inflamm Res"},{"issue":"38","key":"12556_CR12","doi-asserted-by":"publisher","first-page":"20247","DOI":"10.1074\/jbc.M116.732735","volume":"291","author":"D Qin","year":"2016","unstructured":"Qin D, Wang X, Li Y, Yang L, Wang R, Peng J et al (2016) MicroRNA-223-5p and \u2013\u20093p cooperatively suppress necroptosis in ischemic\/reperfused hearts. J Biol Chem 291(38):20247\u201320259. https:\/\/doi.org\/10.1074\/jbc.M116.732735","journal-title":"J BIOL CHEM"},{"key":"12556_CR13","doi-asserted-by":"publisher","first-page":"152338","DOI":"10.1016\/j.bbrc.2025.152338","volume":"778","author":"S Yang","year":"2025","unstructured":"Yang S, Tang S, Xie D, Xu D (2025) Upregulation of miR-223-3p in diabetic cardiomyopathy modulates disease progression via the GRK2\/NLRP3 signaling pathway. Biochem Biophys Res Commun 778:152338. https:\/\/doi.org\/10.1016\/j.bbrc.2025.152338","journal-title":"Biochem Biophys Res Commun"},{"key":"12556_CR14","doi-asserted-by":"publisher","first-page":"1713259","DOI":"10.3389\/fphar.2025.1713259","volume":"16","author":"D Mannino","year":"2025","unstructured":"Mannino D, D\u2019Ariano M, Bello I, Paterniti I, Casili G, Panza E (2025) Molecular insights into NLRP3 inflammasome and miRNA modulation in oral cancer. Front Pharmacol 16:1713259. https:\/\/doi.org\/10.3389\/fphar.2025.1713259","journal-title":"FRONT PHARMACOL"},{"issue":"6","key":"12556_CR15","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1177\/00236772231169550","volume":"57","author":"MJ Bodnar","year":"2023","unstructured":"Bodnar MJ, Ratuski AS, Weary DM (2023) Mouse isoflurane anesthesia using the drop method. Lab Anim 57(6):623\u2013630 . https:\/\/doi.org\/10.1177\/00236772231169550","journal-title":"Lab Anim"},{"issue":"5","key":"12556_CR16","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1177\/00236772221097472","volume":"56","author":"JM Clarkson","year":"2022","unstructured":"Clarkson JM, Martin JE, McKeegan D (2022) A review of methods used to kill laboratory rodents: issues and opportunities. Lab Anim 56(5):419\u2013436. https:\/\/doi.org\/10.1177\/00236772221097472","journal-title":"Lab Anim"},{"key":"12556_CR17","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.yjmcc.2019.04.006","volume":"130","author":"B Haileselassie","year":"2019","unstructured":"Haileselassie B, Mukherjee R, Joshi AU, Napier BA, Massis LM, Ostberg NP et al (2019) Drp1\/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy. J Mol Cell Cardiol 130:160\u2013169. https:\/\/doi.org\/10.1016\/j.yjmcc.2019.04.006","journal-title":"J MOL CELL CARDIOL"},{"key":"12556_CR18","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.yjmcc.2018.08.028","volume":"125","author":"Z Cheng","year":"2018","unstructured":"Cheng Z, Zhang M, Hu J, Lin J, Feng X, Wang S et al (2018) Mst1 knockout enhances cardiomyocyte autophagic flux to alleviate angiotensin II-induced cardiac injury independent of angiotensin II receptors. J Mol Cell Cardiol 125:117\u2013128. https:\/\/doi.org\/10.1016\/j.yjmcc.2018.08.028","journal-title":"J MOL CELL CARDIOL"},{"issue":"1","key":"12556_CR19","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1111\/jcmm.13958","volume":"23","author":"Z Cheng","year":"2019","unstructured":"Cheng Z, Zhang M, Hu J, Lin J, Feng X, Wang S et al (2019) Cardiac-specific Mst1 deficiency inhibits ROS-mediated JNK signalling to alleviate Ang II-induced cardiomyocyte apoptosis. J Cell Mol Med 23(1):543\u2013555. https:\/\/doi.org\/10.1111\/jcmm.13958","journal-title":"J CELL MOL MED"},{"key":"12556_CR20","doi-asserted-by":"publisher","unstructured":"Chen Y, Zhang Z, Zhou G (2026) Advances in the mechanisms of the NLRP3 inflammasome in sepsis\u2013induced cardiomyopathy and targeted therapeutic studies (Review). Mol Med Rep 33(3). https:\/\/doi.org\/10.3892\/mmr.2026.13808","DOI":"10.3892\/mmr.2026.13808"},{"key":"12556_CR21","doi-asserted-by":"publisher","first-page":"1629016","DOI":"10.3389\/fcvm.2025.1629016","volume":"12","author":"Y Niu","year":"2025","unstructured":"Niu Y, Wang L, Zhang Y, Zou Y, Zhou C (2025) Pyroptosis in cardiovascular diseases: roles, mechanisms, and clinical implications. Front Cardiovasc Med 12:1629016. https:\/\/doi.org\/10.3389\/fcvm.2025.1629016","journal-title":"Front Cardiovasc Med"},{"issue":"2","key":"12556_CR22","doi-asserted-by":"publisher","first-page":"417","DOI":"10.3892\/ijmm.2019.4232","volume":"44","author":"C Yang","year":"2019","unstructured":"Yang C, Xia W, Liu X, Lin J, Wu A (2019) Role of TXNIP\/NLRP3 in sepsis-induced myocardial dysfunction. Int J Mol Med 44(2):417\u2013426. https:\/\/doi.org\/10.3892\/ijmm.2019.4232","journal-title":"INT J MOL MED"},{"issue":"12","key":"12556_CR23","doi-asserted-by":"publisher","first-page":"3997","DOI":"10.1096\/fj.201600728R","volume":"30","author":"M Kalbitz","year":"2016","unstructured":"Kalbitz M, Fattahi F, Grailer JJ, Jajou L, Malan EA, Zetoune FS et al (2016) Complement-induced activation of the cardiac NLRP3 inflammasome in sepsis. FASEB J 30(12):3997\u20134006. https:\/\/doi.org\/10.1096\/fj.201600728R","journal-title":"FASEB J"},{"issue":"49","key":"12556_CR24","doi-asserted-by":"publisher","first-page":"19725","DOI":"10.1073\/pnas.1108586108","volume":"108","author":"E Mezzaroma","year":"2011","unstructured":"Mezzaroma E, Toldo S, Farkas D, Seropian IM, Van Tassell BW, Salloum FN et al (2011) The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse. Proc Natl Acad Sci U S A 108(49):19725\u201319730. https:\/\/doi.org\/10.1073\/pnas.1108586108","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"22","key":"12556_CR25","doi-asserted-by":"publisher","first-page":"2530","DOI":"10.1161\/CIRCULATIONAHA.118.034621","volume":"138","author":"T Suetomi","year":"2018","unstructured":"Suetomi T, Willeford A, Brand CS, Cho Y, Ross RS, Miyamoto S et al (2018) Inflammation and NLRP3 inflammasome activation initiated in response to pressure overload by Ca (2+)\/Calmodulin-dependent protein kinase II \u03b4 signaling in cardiomyocytes are essential for adverse cardiac remodeling. Circulation 138(22):2530\u20132544. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.118.034621","journal-title":"Circulation"},{"issue":"8","key":"12556_CR26","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1161\/CIRCRESAHA.120.316710","volume":"127","author":"J Heijman","year":"2020","unstructured":"Heijman J, Muna AP, Veleva T, Molina CE, Sutanto H, Tekook M et al (2020) Atrial myocyte NLRP3\/CaMKII nexus forms a substrate for postoperative atrial fibrillation. Circ Res 127(8):1036\u20131055. https:\/\/doi.org\/10.1161\/CIRCRESAHA.120.316710","journal-title":"CIRC RES"},{"issue":"3","key":"12556_CR27","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.3892\/ijmm.2019.4075","volume":"43","author":"Y Yan","year":"2019","unstructured":"Yan Y, Lu K, Ye T, Zhang Z (2019) MicroRNA\u2013223 attenuates LPS\u2013induced inflammation in an acute lung injury model via the NLRP3 inflammasome and TLR4\/NF\u2013\u03baB signaling pathway via RHOB. Int J Mol Med 43(3):1467\u20131477. https:\/\/doi.org\/10.3892\/ijmm.2019.4075","journal-title":"INT J MOL MED"},{"key":"12556_CR28","doi-asserted-by":"publisher","first-page":"1697422","DOI":"10.3389\/fphar.2025.1697422","volume":"16","author":"Z Ye","year":"2025","unstructured":"Ye Z, Liu M, Zhang X, Wu H, Qiu Z, Chai R et al (2025) Xin-Fu-Kang oral liquid improves cardiac function and attenuates miR-223-associated NF-\u03baB\/NLRP3 pyroptotic signaling in chronic heart failure. Front Pharmacol 16:1697422. https:\/\/doi.org\/10.3389\/fphar.2025.1697422","journal-title":"FRONT PHARMACOL"},{"key":"12556_CR29","doi-asserted-by":"publisher","unstructured":"Fan Z, Xu M, Shen Y (2025) MiR-223-3p Positively regulates sepsis-induced inflammatory responses by targeting the ubiquitin ligase FBXW7. J Evolutionary Biochem Physiol 61(2). https:\/\/doi.org\/10.1134\/S002209302460043X","DOI":"10.1134\/S002209302460043X"},{"key":"12556_CR30","doi-asserted-by":"publisher","first-page":"112164","DOI":"10.1016\/j.cellsig.2025.112164","volume":"136","author":"J Rao","year":"2025","unstructured":"Rao J, Ding C, Huang X, Li J, Liu J, Cheng Z et al (2025) Mechanistic insights into homocysteine-induced coronary microcirculatory dysfunction post-MI: The pivotal role of LncMEG3\/miR-223\/NLRP3 signaling axis. Cell Signal 136:112164. https:\/\/doi.org\/10.1016\/j.cellsig.2025.112164","journal-title":"CELL SIGNAL"},{"issue":"6","key":"12556_CR31","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1016\/j.chest.2025.08.013","volume":"168","author":"R Sato","year":"2025","unstructured":"Sato R, Sanfilippo F, Lanspa M, Duggal A, Dugar S (2025) Sepsis-induced cardiomyopathy: mechanism, prevalence, assessment, prognosis, and management. Chest 168(6):1383\u20131394. https:\/\/doi.org\/10.1016\/j.chest.2025.08.013","journal-title":"Chest"},{"issue":"5","key":"12556_CR32","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1038\/s41418-025-01612-6","volume":"33","author":"D Xu","year":"2026","unstructured":"Xu D, Han J, Ye B, Lin L, Chen J, Jin Y et al (2026) USP13 ameliorates diabetic cardiomyopathy via deubiquitinating NLRP3 and inhibiting pyroptosis in cardiomyocytes. CELL DEATH DIFFER 33(5):914\u2013929. https:\/\/doi.org\/10.1038\/s41418-025-01612-6","journal-title":"CELL DEATH DIFFER"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12556-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12556-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12556-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T11:41:41Z","timestamp":1786362101000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12556-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,10]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12556"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12556-6","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,10]]},"assertion":[{"value":"6 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study received approval from the Ethics Committee of Xinjiang Medical University, as denoted by Reference Number: LFYLLSC20201013-06.","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Patient Anonymity and Informed Consent","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that all animal experiments in this study were designed, performed, and reported in strict compliance with the ARRIVE Guidelines 2.0 (Animal Research: Reporting of In Vivo Experiments). All essential items of the ARRIVE Essential 10 set and key items of the Recommended Set were fully addressed in the manuscript to ensure transparency, reproducibility, and reliability of the animal study results.","order":4,"name":"Ethics","label":"ARRIVE Guidelines Compliance Statement","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1375"}}