{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:29:24Z","timestamp":1786364964455,"version":"build-2736575974"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004006","name":"Bilimsel Ara\u015ftirma Projeleri Birimi, Istanbul \u00dcniversitesi","doi-asserted-by":"publisher","award":["TYL-2024-41090"],"award-info":[{"award-number":["TYL-2024-41090"]}],"id":[{"id":"10.13039\/501100004006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002657","name":"Istanbul \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002657","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12574-4","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T11:42:43Z","timestamp":1786362163000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["DHRS2 regulates epithelial-mesenchymal transition in breast cancer cells"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5013-5542","authenticated-orcid":false,"given":"H\u00fcmeyra","family":"Karaca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9144-3899","authenticated-orcid":false,"given":"Burcu Salman","family":"Yaylaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0527-297X","authenticated-orcid":false,"given":"Vahideh","family":"Zarerajabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7722-7401","authenticated-orcid":false,"given":"\u015eeyma","family":"Punar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1201-7542","authenticated-orcid":false,"given":"Sema Sirma","family":"Ekmekci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9962-4010","authenticated-orcid":false,"given":"Neslihan","family":"Abaci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"12574_CR1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.biocel.2018.01.003","volume":"96","author":"N Brook","year":"2018","unstructured":"Brook N, Brook E, Dharmarajan A, Dass CR, Chan A (2018) Breast cancer bone metastases: pathogenesis and therapeutic targets. Int J Biochem Cell Biol [Internet] Elsevier 96:63\u201378. https:\/\/doi.org\/10.1016\/j.biocel.2018.01.003","journal-title":"Int J Biochem Cell Biol [Internet] Elsevier"},{"key":"12574_CR2","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s10555-007-9083-x","volume":"26","author":"X Cheng","year":"2007","unstructured":"Cheng X, Hung MC (2007) Breast cancer brain metastases. Cancer Metastasis Rev 26:635\u2013643. https:\/\/doi.org\/10.1007\/s10555-007-9083-x","journal-title":"Cancer Metastasis Rev"},{"key":"12574_CR3","unstructured":"Katsura C, Ogunmwonyi I, Saha S, Katsura C (2024) Doctors in Training Breast cancer: presentation, investigation and management. ;4\u201310"},{"key":"12574_CR4","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.ccell.2023.11.008","volume":"42","author":"A Sreekumar","year":"2024","unstructured":"Sreekumar A, Lu M, Choudhury B, Pan T, chi, Pant DK, Lawrence-Paul MR et al (2024) B3GALT6 promotes dormant breast cancer cell survival and recurrence by enabling heparan sulfate-mediated FGF signaling. Cancer Cell 42:52\u201369e7. https:\/\/doi.org\/10.1016\/j.ccell.2023.11.008","journal-title":"Cancer Cell"},{"key":"12574_CR5","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-32-9620-6_2","author":"YJ Lee","year":"2021","unstructured":"Lee YJ, Shin KJ, Jang HJ, Noh DY, Ryu SH, Suh PG (2021) Phospholipase Signaling in Breast Cancer. Adv Exp Med Biol. https:\/\/doi.org\/10.1007\/978-981-32-9620-6_2","journal-title":"Adv Exp Med Biol"},{"key":"12574_CR6","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41580-018-0080-4","volume":"20","author":"A Dongre","year":"2019","unstructured":"Dongre A, Weinberg RA (2019) New insights into the mechanisms of epithelial\u2013mesenchymal transition and implications for cancer. Nat Rev Mol Cell Biol [Internet] Springer US 20:69\u201384. https:\/\/doi.org\/10.1038\/s41580-018-0080-4","journal-title":"Nat Rev Mol Cell Biol [Internet] Springer US"},{"key":"12574_CR7","doi-asserted-by":"publisher","first-page":"100773","DOI":"10.1016\/j.tranon.2020.100773","volume":"13","author":"D Ribatti","year":"2020","unstructured":"Ribatti D, Tamma R, Annese T (2020) Epithelial-Mesenchymal Transition in Cancer: A Historical Overview. Transl Oncol [Internet]. Authors 13:100773. https:\/\/doi.org\/10.1016\/j.tranon.2020.100773","journal-title":"Authors"},{"key":"12574_CR8","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1007\/s00018-006-6013-y","volume":"63","author":"N Shafqat","year":"2006","unstructured":"Shafqat N, Shafqat J, Eissner G, Marschall HU, Tryggvason K, Eriksson U et al (2006) Hep27, a member of the short-chain dehydrogenase\/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue. Cell Mol Life Sci 63:1205\u20131213. https:\/\/doi.org\/10.1007\/s00018-006-6013-y","journal-title":"Cell Mol Life Sci"},{"key":"12574_CR9","doi-asserted-by":"publisher","unstructured":"Li Z, Tan Y, Li X, Quan J, Bode AM, Cao Y et al (2022) DHRS2 inhibits cell growth and metastasis in ovarian cancer by downregulation of CHK\u03b1 to disrupt choline metabolism. Cell Death Dis Springer US 13. https:\/\/doi.org\/10.1038\/s41419-022-05291-w","DOI":"10.1038\/s41419-022-05291-w"},{"key":"12574_CR10","doi-asserted-by":"publisher","unstructured":"Salman Yaylaz B, S\u0131rma Ekmekci S, \u00c7\u0131nar S, Deniz G, Abac\u0131 N (2021) DHRS2 is a potential marker of breast cancer metastasis. https:\/\/doi.org\/10.1016\/j.genrep.2021.101302. https:\/\/doi.org\/","DOI":"10.1016\/j.genrep.2021.101302"},{"key":"12574_CR11","doi-asserted-by":"publisher","unstructured":"Guo Q, Pei X, hua, Chu A, jing, Guo Y, bo, Fan Y yi, Wang Chui et al (2022) The mechanism of action of Fangji Huangqi Decoction on epithelial-mesenchymal transition in breast cancer using high-throughput next-generation sequencing and network pharmacology. J Ethnopharmacol [Internet]. Elsevier B.V.; ;284:114793. https:\/\/doi.org\/10.1016\/j.jep.2021.114793","DOI":"10.1016\/j.jep.2021.114793"},{"key":"12574_CR12","doi-asserted-by":"publisher","first-page":"226","DOI":"10.4274\/tjh.galenos.2020.2020.0144","volume":"37","author":"SS Ekmekci","year":"2020","unstructured":"Ekmekci SS, Emrence Z, Abac\u0131 N, Sar\u0131man M, Salman B, Ekmekci CG et al (2020) Lef1 induces dhrs2 gene expression in human acute leukemia jurkat t-cells. Turkish J Hematol 37:226\u2013233. https:\/\/doi.org\/10.4274\/tjh.galenos.2020.2020.0144","journal-title":"Turkish J Hematol"},{"key":"12574_CR13","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 71:209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA Cancer J Clin"},{"key":"12574_CR14","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/nrc1670","volume":"5","author":"B Weigelt","year":"2005","unstructured":"Weigelt B, Peterse JL, Van\u2019t Veer LJ (2005) Breast cancer metastasis: Markers and models. Nat Rev Cancer 5:591\u2013602. https:\/\/doi.org\/10.1038\/nrc1670","journal-title":"Nat Rev Cancer"},{"key":"12574_CR15","doi-asserted-by":"publisher","unstructured":"Chen LL, Gao GX, Shen FX, Chen X, Gong XH, Wu WJ (2018) SDC4 gene silencing favors human papillary thyroid carcinoma cell apoptosis and inhibits epithelial mesenchymal transition via wnt\/\u03b2-catenin pathway. Mol Cells [Internet]. THE AUTHORS. Published by Elsevier Inc on behalf of the Korean Society for Molecular and Cellular Biology. 41:853\u2013867. https:\/\/doi.org\/10.14348\/molcells.2018.0103g","DOI":"10.14348\/molcells.2018.0103g"},{"key":"12574_CR16","first-page":"1983","volume":"18","author":"X Bao","year":"2012","unstructured":"Bao X, Song H, Chen Z, Tang X (2012) Wnt3a promotes epithelial-mesenchymal transition, migration, and proliferation of lens epithelial cells. Mol Vis 18:1983\u20131990","journal-title":"Mol Vis"},{"key":"12574_CR17","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1158\/1541-7786.MCR-12-0155-T","volume":"10","author":"Y Wu","year":"2012","unstructured":"Wu Y, Ginther C, Kim J, Mosher N, Chung S, Slamon D et al (2012) Expression of Wnt3 activates Wnt\/\u03b2-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells. Mol Cancer Res 10:1597\u20131606. https:\/\/doi.org\/10.1158\/1541-7786.MCR-12-0155-T","journal-title":"Mol Cancer Res"},{"key":"12574_CR18","doi-asserted-by":"publisher","unstructured":"Mei Y, Zhao L, Zhou N (2025) SDC1 is a critical transmembrane proteoglycan in breast cancer. World J Surg Oncol 23. https:\/\/doi.org\/10.1186\/s12957-025-03840-z","DOI":"10.1186\/s12957-025-03840-z"},{"key":"12574_CR19","doi-asserted-by":"publisher","unstructured":"Lin W, Xu B (2026) SDC1 Knockdown Suppresses Malignant Phenotypes of Breast Cancer by Modulating the MAPK Signaling Pathway. https:\/\/doi.org\/10.1002\/cam4.72016","DOI":"10.1002\/cam4.72016"},{"key":"12574_CR20","doi-asserted-by":"publisher","first-page":"152756","DOI":"10.1016\/j.prp.2019.152756","volume":"216","author":"S Liao","year":"2020","unstructured":"Liao S, Liu C, Zhu G, Wang K, Yang Y, Wang C (2020) Relationship between SDC1 and cadherin signalling activation in cancer. Pathol Res Pract [Internet] Elsevier 216:152756. https:\/\/doi.org\/10.1016\/j.prp.2019.152756","journal-title":"Pathol Res Pract [Internet] Elsevier"},{"key":"12574_CR21","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1097\/SCS.0000000000010958","volume":"36","author":"L Zhao","year":"2025","unstructured":"Zhao L, Feng P, Quan X, Zhou M, Yang K, Cui A et al (2025) SDC1 Influences Keloid Fibroblasts Migration and Invasion via Targeting Wnt\/\u03b2-Catenin Signaling Pathway Mediated EMT. J Craniofac Surg 36:727\u2013731. https:\/\/doi.org\/10.1097\/SCS.0000000000010958","journal-title":"J Craniofac Surg"},{"key":"12574_CR22","doi-asserted-by":"publisher","first-page":"9243","DOI":"10.1038\/sj.onc.1207217","volume":"22","author":"BY Liu","year":"2003","unstructured":"Liu BY, Kim YC, Leatherberry V, Cowin P, Alexander CM (2003) Mammary gland development requires syndecan-1 to create a \u03b2-catenin\/TCF-responsive mammary epithelial subpopulation. Oncogene 22:9243\u20139253. https:\/\/doi.org\/10.1038\/sj.onc.1207217","journal-title":"Oncogene"},{"key":"12574_CR23","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1093\/carcin\/bgp001","volume":"30","author":"V Nikolova","year":"2009","unstructured":"Nikolova V, Koo CY, Ibrahim SA, Wang Z, Spillmann D, Dreier R et al (2009) Differential roles for membrane-bound and soluble syndecan-1 (CD138) in breast cancer progression. Carcinogenesis 30:397\u2013407. https:\/\/doi.org\/10.1093\/carcin\/bgp001","journal-title":"Carcinogenesis"},{"key":"12574_CR24","doi-asserted-by":"publisher","first-page":"13988","DOI":"10.1074\/jbc.M112.444737","volume":"288","author":"K Chen","year":"2013","unstructured":"Chen K, Williams KJ (2013) Molecular mediators for raft-dependent endocytosis of syndecan-1, a highly conserved, multifunctional receptor. J Biol Chem 288:13988\u201313999. https:\/\/doi.org\/10.1074\/jbc.M112.444737","journal-title":"J Biol Chem"},{"key":"12574_CR25","doi-asserted-by":"publisher","first-page":"111144","DOI":"10.18632\/oncotarget.22676","volume":"8","author":"P Zhou","year":"2017","unstructured":"Zhou P, Zhang R, Wang Y, Xu D, Zhang L, Qin J et al (2017) Cepharanthine hydrochloride reverses the mdr1 (P-glycoprotein)- mediated esophageal squamous cell carcinoma cell cisplatin resistance through JNK and p53 signals. Oncotarget 8:111144\u2013111160. https:\/\/doi.org\/10.18632\/oncotarget.22676","journal-title":"Oncotarget"},{"key":"12574_CR26","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1002\/cncr.11515","volume":"98","author":"M Barbareschi","year":"2003","unstructured":"Barbareschi M, Maisonneuve P, Aldovini D, Cangi MG, Pecciarini L, Mauri FA et al (2003) High syndecan-1 expression in breast carcinoma is related to an aggressive phenotype and to poorer prognosis. Cancer 98:474\u2013483. https:\/\/doi.org\/10.1002\/cncr.11515","journal-title":"Cancer"},{"key":"12574_CR27","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/j.1349-7006.2009.01379.x","volume":"101","author":"K Shimada","year":"2010","unstructured":"Shimada K, Nakamura M, De Velasco MA, Tanaka M, Ouji Y, Miyake M et al (2010) Role of syndecan-1 (CD138) in cell survival of human urothelial carcinoma. Cancer Sci 101:155\u2013160. https:\/\/doi.org\/10.1111\/j.1349-7006.2009.01379.x","journal-title":"Cancer Sci"},{"key":"12574_CR28","doi-asserted-by":"publisher","first-page":"5817","DOI":"10.1038\/s41388-019-0845-z","volume":"38","author":"S Mishra","year":"2019","unstructured":"Mishra S, Bernal C, Silvano M, Anand S, Ruiz i Altaba A (2019) The protein secretion modulator TMED9 drives CNIH4\/TGF\u03b1\/GLI signaling opposing TMED3-WNT-TCF to promote colon cancer metastases. Oncogene [Internet] Springer US 38:5817\u20135837. https:\/\/doi.org\/10.1038\/s41388-019-0845-z","journal-title":"Oncogene [Internet] Springer US"},{"key":"12574_CR29","doi-asserted-by":"publisher","first-page":"4256","DOI":"10.4161\/cc.10.24.18552","volume":"10","author":"H Siemens","year":"2011","unstructured":"Siemens H, Jackstadt R, H\u00fcnten S, Kaller M, Menssen A, G\u00f6tz U et al (2011) miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions. Cell Cycle 10:4256\u20134271. https:\/\/doi.org\/10.4161\/cc.10.24.18552","journal-title":"Cell Cycle"},{"key":"12574_CR30","first-page":"3961","volume":"35","author":"J Grzegrzolka","year":"2015","unstructured":"Grzegrzolka J, Biala M, Wojtyra P, Kobierzycki C, Olbromski M, Gomulkiewicz A et al (2015) Expression of EMT markers SLUG and TWIST in breast cancer. Anticancer Res 35:3961\u20133968","journal-title":"Anticancer Res"},{"key":"12574_CR31","doi-asserted-by":"publisher","unstructured":"Li J, Zhou BP (2011) Activation of \u03b2-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters. BMC Cancer 11. https:\/\/doi.org\/10.1186\/1471-2407-11-49","DOI":"10.1186\/1471-2407-11-49"},{"key":"12574_CR32","doi-asserted-by":"publisher","unstructured":"Ramalingam PS, Ilma B, Hussain S, Jakhmola V, Fatima R, Mekala JR et al (2026) The central role of EMT in tumor progression: mechanistic drivers, biomarker discovery, and therapeutic horizons. 2026:1\u201320. https:\/\/doi.org\/10.3389\/fphar.2026.1820481","DOI":"10.3389\/fphar.2026.1820481"},{"key":"12574_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cancers13194985","volume":"13","author":"S Usman","year":"2021","unstructured":"Usman S, Waseem NH, Nguyen TKN, Mohsin S, Jamal A, Teh MT et al (2021) Vimentin is at the heart of epithelial mesenchymal transition (Emt) mediated metastasis. Cancers (Basel) 13:1\u201326. https:\/\/doi.org\/10.3390\/cancers13194985","journal-title":"Cancers (Basel)"},{"key":"12574_CR34","doi-asserted-by":"publisher","unstructured":"Verstappe J, Berx G (2023) A role for partial epithelial-to-mesenchymal transition in enabling stemness in homeostasis and cancer. https:\/\/doi.org\/10.1016\/j.semcancer.2023.02.001. https:\/\/doi.org\/","DOI":"10.1016\/j.semcancer.2023.02.001"},{"key":"12574_CR35","doi-asserted-by":"crossref","unstructured":"Wang C, Sarubo M, Chen S, Kudo Y (2025) Partial-EMT in oral squamous cell carcinoma: molecular circuitry and clinical translation. Springer US, pp 1\u201315","DOI":"10.1038\/s41368-025-00417-0"},{"key":"12574_CR36","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.imbio.2011.07.018","volume":"217","author":"K Kawabe","year":"2012","unstructured":"Kawabe K, Lindsay D, Braitch M, Fahey AJ, Showe L, Constantinescu CS (2012) IL-12 inhibits glucocorticoid-induced T cell apoptosis by inducing GMEB1 and activating PI3K\/Akt pathway. Immunobiol [Internet] 217:118\u2013123. https:\/\/doi.org\/10.1016\/j.imbio.2011.07.018","journal-title":"Immunobiol [Internet]"},{"key":"12574_CR37","doi-asserted-by":"publisher","unstructured":"Nakagawa T, Tsuruma K, Takashi U, Nomura Y (2008) GMEB1, a novel endogenous caspase inhibitor, prevents hypoxia- and oxidative stress-induced neuronal apoptosis. https:\/\/doi.org\/10.1016\/j.neulet.2008.04.023. https:\/\/doi.org\/","DOI":"10.1016\/j.neulet.2008.04.023"},{"key":"12574_CR38","doi-asserted-by":"publisher","first-page":"988","DOI":"10.4251\/wjgo.v15.i6.988","volume":"15","author":"C Chen","year":"2023","unstructured":"Chen C, Lin HG, Yao Z, Jiang YL, Yu HJ, Fang J et al (2023) Transcription factor glucocorticoid modulatory element-binding protein 1 promotes hepatocellular carcinoma progression by activating Yes-associate protein 1. World J Gastrointest Oncol 15:988\u20131004. https:\/\/doi.org\/10.4251\/wjgo.v15.i6.988","journal-title":"World J Gastrointest Oncol"},{"key":"12574_CR39","doi-asserted-by":"publisher","unstructured":"Zou H, Chen H, Liu S, Gan X (2021) Identification of a novel circ _ 0018289 \/ miR \u2013 183 \u2013 5p \/ TMED5 regulatory network in cervical cancer development. World J Surg Oncol [Internet] BioMed Cent 1\u201313. https:\/\/doi.org\/10.1186\/s12957-021-02350-y","DOI":"10.1186\/s12957-021-02350-y"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12574-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12574-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12574-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T11:42:46Z","timestamp":1786362166000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12574-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,10]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12574"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12574-4","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,10]]},"assertion":[{"value":"27 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no known conflicts of interest or personal relationships that could influence the work reported in this article.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethics committee approval was not required for this study as it involved established human cell lines and did not include human or animal subjects.","order":2,"name":"Ethics","label":"Ethics Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was not applicable as no human participants were involved in the study.","order":3,"name":"Ethics","label":"Informed Consent","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1374"}}