{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:35:01Z","timestamp":1786707301723,"version":"build-2736575974"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12599-9","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:40:49Z","timestamp":1786700449000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biochemical and cellular effects of propolis and silver nanoparticle combination: apoptotic signaling and antibiofilm activity"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1626-6033","authenticated-orcid":false,"given":"Esra","family":"Erdo\u011fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4481-2866","authenticated-orcid":false,"given":"Berna","family":"\u00d6zdem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7319-3526","authenticated-orcid":false,"given":"\u00d6zge \u00d6zt\u00fcrk","family":"\u00c7imentepe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3300-8020","authenticated-orcid":false,"given":"Ibrahim","family":"Tekedereli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3027-6054","authenticated-orcid":false,"given":"I\u015f\u0131l","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"issue":"23","key":"12599_CR1","doi-asserted-by":"publisher","first-page":"7773","DOI":"10.3390\/molecules28237773","volume":"28","author":"A Saleem","year":"2023","unstructured":"Saleem A, Ali S, Aftab MN, Shami A, Al-Saeed FA, Mustafa B et al (2023) The characterization and study of antibacterial, free radical scavenging, and anticancer potential of Livistona chinensis-mediated silver nanoparticles. Molecules 28(23):7773","journal-title":"Molecules"},{"key":"12599_CR2","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.bbrc.2023.06.083","volume":"674","author":"AH Kaynar","year":"2023","unstructured":"Kaynar AH, \u00c7\u00f6meleko\u011flu \u00dc, Kibar D, Y\u0131ld\u0131r\u0131m M, Y\u0131ld\u0131r\u0131mcan S, Y\u0131lmaz \u015eN et al (2023) Cytotoxic effect of silica nanoparticles on human retinal pigment epithelial cells. Biochem Biophys Res Commun 674:53\u201361","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"12599_CR3","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.1080\/21691401.2019.1638792","volume":"47","author":"K Zhang","year":"2019","unstructured":"Zhang K, Liu X, Samuel Ravi SOA, Ramachandran A, Aziz Ibrahim IA, Nassir M (2019) Synthesis of silver nanoparticles (AgNPs) from leaf extract of Salvia miltiorrhiza and its anticancer potential in human prostate cancer LNCaP cell lines. Artif Cells Nanomed Biotechnol 47(1):2846\u20132854","journal-title":"Artif Cells Nanomed Biotechnol"},{"issue":"5","key":"12599_CR4","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.joim.2021.08.002","volume":"19","author":"PT Seven","year":"2021","unstructured":"Seven PT, Seven I, Karakus S, Mutlu SI, Kaya SO, Arkali G et al (2021) The in-vivo assessment of Turkish propolis and its nano form on testicular damage induced by cisplatin. J Integr Med 19(5):451\u2013459","journal-title":"J Integr Med"},{"issue":"2","key":"12599_CR5","first-page":"74","volume":"4","author":"B \u00d6zdem","year":"2024","unstructured":"\u00d6zdem B, Erdo\u011fan E (2024) Effects of Propolis on Oral Health and Oral Cavity Cancers. HRU Int J Dentistry Oral Res 4(2):74\u201381","journal-title":"HRU Int J Dentistry Oral Res"},{"issue":"6","key":"12599_CR6","doi-asserted-by":"publisher","first-page":"5128","DOI":"10.1039\/D5RA08728G","volume":"16","author":"H Singh","year":"2026","unstructured":"Singh H, Balusamy SR, Sukweenadhi J, Shrivastav A, Mohanprasanth A, Saravanan M et al (2026) Engineering combination nanomedicines to overcome cancer resistance. RSC Adv 16(6):5128\u20135167","journal-title":"RSC Adv"},{"issue":"9","key":"12599_CR7","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.3390\/plants9091075","volume":"9","author":"P Tatli Seven","year":"2020","unstructured":"Tatli Seven P, Seven I, Karakus S, Iflazoglu Mutlu S, Arkali G, Muge Sahin Y et al (2020) Turkish propolis and its nano form can ameliorate the side effects of cisplatin, which is a widely used drug in the treatment of cancer. Plants 9(9):1075","journal-title":"Plants"},{"issue":"1","key":"12599_CR8","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s13568-022-01450-6","volume":"12","author":"N Rezk","year":"2022","unstructured":"Rezk N, Abdelsattar AS, Makky S, Hussein AH, Kamel AG, El-Shibiny A (2022) New formula of the green synthesised Au@ Ag core@ shell nanoparticles using propolis extract presented high antibacterial and anticancer activity. AMB Express 12(1):108","journal-title":"AMB Express"},{"issue":"5","key":"12599_CR9","doi-asserted-by":"publisher","first-page":"524","DOI":"10.3390\/pr8050524","volume":"8","author":"HM Al-Yousef","year":"2020","unstructured":"Al-Yousef HM, Amina M, Alqahtani AS, Alqahtani MS, Malik A, Hatshan MR et al (2020) Pollen bee aqueous extract-based synthesis of silver nanoparticles and evaluation of their anti-cancer and anti-bacterial activities. Processes 8(5):524","journal-title":"Processes"},{"issue":"1","key":"12599_CR10","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1186\/s12951-025-03712-4","volume":"23","author":"H Singh","year":"2025","unstructured":"Singh H, Balusamy SR, Sukweenadhi J, Saravanan M, Aruchamy M, Mijakovic I et al (2025) Smart hybrid nanomaterials for chronic infections: microbiome-responsive and sustainable therapeutic platforms. J Nanobiotechnol 23(1):698","journal-title":"J Nanobiotechnol"},{"issue":"10474","key":"12599_CR11","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0140-6736(24)02081-6","volume":"405","author":"N Macesic","year":"2025","unstructured":"Macesic N, Uhlemann A-C, Peleg AY (2025) Multidrug-resistant Gram-negative bacterial infections. Lancet 405(10474):257\u2013272","journal-title":"Lancet"},{"issue":"6","key":"12599_CR12","doi-asserted-by":"publisher","first-page":"e02260","DOI":"10.1128\/mbio.02260-23","volume":"14","author":"C M\u00fcller","year":"2023","unstructured":"M\u00fcller C, Reuter S, Wille J, Xanthopoulou K, Stefanik D, Grundmann H et al (2023) A global view on carbapenem-resistant Acinetobacter baumannii. MBio 14(6):e02260\u2013e02223","journal-title":"MBio"},{"issue":"2","key":"12599_CR13","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s40121-022-00597-w","volume":"11","author":"C Bartal","year":"2022","unstructured":"Bartal C, Rolston KV, Nesher L (2022) Carbapenem-resistant Acinetobacter baumannii: colonization, infection and current treatment options. Infect Dis therapy 11(2):683\u2013694","journal-title":"Infect Dis therapy"},{"issue":"1","key":"12599_CR14","doi-asserted-by":"publisher","first-page":"126","DOI":"10.5455\/OVJ.2025.v15.i1.12","volume":"15","author":"MB Gomaa","year":"2025","unstructured":"Gomaa MB, Abdelhameed KM, Sobhy SE, Konper HM, Hassanein ZA, Saleh AA et al (2025) Antioxidant activity, antibacterial behavior, and anticancer impact of Egyptian propolis. Open Veterinary J 15(1):126","journal-title":"Open Veterinary J"},{"issue":"1","key":"12599_CR15","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/s11033-025-10924-2","volume":"52","author":"G Dervi\u015fo\u011flu","year":"2025","unstructured":"Dervi\u015fo\u011flu G, Kaya B, Aykuto\u011flu G, Darendelio\u011flu E, Ayna A (2025) Synthesis of silver nanoparticles reduced by Bing\u00f6l propolis and evaluation of antioxidant, anticancer and cytotoxic activities in PC-3 cells. Mol Biol Rep 52(1):811","journal-title":"Mol Biol Rep"},{"issue":"8","key":"12599_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12032-025-02888-x","volume":"42","author":"E Erdo\u011fan","year":"2025","unstructured":"Erdo\u011fan E, \u00d6zdem B, \u00c7imentepe \u00d6\u00d6, Tekedereli \u0130 (2025) Anatolian propolis extracts enhance cisplatin efficacy in ovarian cancer through AKT\/mTOR pathway modulation and demonstrate antibacterial and antibiofilm activities. Med Oncol 42(8):1\u201318","journal-title":"Med Oncol"},{"issue":"6","key":"12599_CR17","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1007\/s11094-024-03229-4","volume":"58","author":"B \u00d6zdem","year":"2024","unstructured":"\u00d6zdem B, Yildirim I, Kilin\u00e7li \u00c7etin A, Tekedereli I (2024) Cynarine Exhibits Antiproliferative Activity and Bcl-2-Mediated Apoptotic Cell Death in Breast Cancer Cells. Pharm Chem J 58(6):963\u2013967","journal-title":"Pharm Chem J"},{"issue":"1","key":"12599_CR18","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1007\/s11033-024-09939-y","volume":"51","author":"N Meri\u00e7","year":"2024","unstructured":"Meri\u00e7 N, Kar E, Kar F (2024) 4-Methylthiazole triggers apoptosis and mitochondrial disruption in HL-60 cells. Mol Biol Rep 51(1):997","journal-title":"Mol Biol Rep"},{"issue":"6","key":"12599_CR19","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.55730\/1300-0144.5734","volume":"53","author":"E Onat","year":"2023","unstructured":"Onat E, \u00d6nalan E, \u00d6zdem B, Balgetir MK, Kulo\u011flu T (2023) Effect of humanine on the Notch signaling pathway in myocardial infarction. Turk J Med Sci 53(6):1658\u20131666","journal-title":"Turk J Med Sci"},{"issue":"2","key":"12599_CR20","first-page":"372","volume":"5","author":"A Gahlaut","year":"2013","unstructured":"Gahlaut A, Chhillar AK (2013) Evaluation of antibacterial potential of plant extracts using resazurin based microtiter dilution assay. Int J Pharm Pharm Sci 5(2):372\u2013376","journal-title":"Int J Pharm Pharm Sci"},{"key":"12599_CR21","doi-asserted-by":"publisher","first-page":"142320","DOI":"10.1016\/j.molstruc.2025.142320","volume":"1338","author":"B Demirba\u011f","year":"2025","unstructured":"Demirba\u011f B, Yildirim M, Cimentepe M, Necip A, Unver H, Tiftik EN (2025) Novel vanillin-derived Schiff Bases: Synthesis, characterization, antibacterial activity, enzyme inhibition, antioxidant activity, anti-inflammatory activity on LPS-induced RAW264. 7 macrophage cell line, and In Silico studies. J Mol Struct 1338:142320","journal-title":"J Mol Struct"},{"issue":"12","key":"12599_CR22","doi-asserted-by":"publisher","first-page":"7903","DOI":"10.1007\/s11696-023-03060-3","volume":"77","author":"C Yamali","year":"2023","unstructured":"Yamali C, Sevin S, Nenni M, Tugrak Sakarya M, Uyar R, Aygul A et al (2023) Design, synthesis, and assessment of pharmacological properties of indole-based fluorinated chalcones and their benzenesulfonamide analogs. Chem Pap 77(12):7903\u20137918","journal-title":"Chem Pap"},{"key":"12599_CR23","doi-asserted-by":"publisher","first-page":"1513875","DOI":"10.3389\/fpls.2024.1513875","volume":"15","author":"M Amangeldinova","year":"2024","unstructured":"Amangeldinova M, Ersat\u0131r M, Necip A, Yilmaz MA, Cimentepe M, Kudrina N et al (2024) Simultaneous quantitative screening of 53 phytochemicals from Rheum tataricum L. roots: a comparative study of supercritical CO2, subcritical ethanol, and ultrasound-assisted extraction for enhanced antioxidant, antibacterial activities, and molecular docking study. Front Plant Sci 15:1513875","journal-title":"Front Plant Sci"},{"issue":"1","key":"12599_CR24","first-page":"3057754","volume":"2021","author":"A Kotzialampou","year":"2021","unstructured":"Kotzialampou A, Protonotariou E, Skoura L, Sivropoulou A (2021) Synergistic antibacterial and antibiofilm activity of the MreB inhibitor A22 hydrochloride in combination with conventional antibiotics against pseudomonas aeruginosa and escherichia coli clinical isolates. Int J Microbiol 2021(1):3057754","journal-title":"Int J Microbiol"},{"key":"12599_CR25","doi-asserted-by":"crossref","unstructured":"Odds FC (2003) Synergy, antagonism, and what the chequerboard puts between them. Oxford University Press, p 1","DOI":"10.1093\/jac\/dkg301"},{"key":"12599_CR26","doi-asserted-by":"publisher","unstructured":"Y\u0131ld\u0131r\u0131m, M., \u00dcnver, H., Necip, A., & \u00c7imentepe, M. (2025). Design, synthesis, and biological evaluation of novel vanillin-derived hydrazone compounds with antimicrobial, anticancer, and enzyme inhibition activities, along with molecular structure and drug-likeness assessment. Biochem. biophys. res. comms, 775, 152173. https:\/\/doi.org\/10.1016\/j.bbrc.2025.152173","DOI":"10.1016\/j.bbrc.2025.152173"},{"key":"12599_CR27","doi-asserted-by":"publisher","first-page":"112670","DOI":"10.1016\/j.biopha.2022.112670","volume":"147","author":"R Mirzaei","year":"2022","unstructured":"Mirzaei R, Alikhani MY, Arciola CR, Sedighi I, Yousefimashouf R, Bagheri KP (2022) Prevention, inhibition, and degradation effects of melittin alone and in combination with vancomycin and rifampin against strong biofilm producer strains of methicillin-resistant Staphylococcus epidermidis. Biomed Pharmacother 147:112670","journal-title":"Biomed Pharmacother"},{"key":"12599_CR28","doi-asserted-by":"publisher","first-page":"103053","DOI":"10.1016\/j.cis.2023.103053","volume":"323","author":"X Gong","year":"2024","unstructured":"Gong X, Jadhav ND, Lonikar VV, Kulkarni AN, Zhang H, Sankapal BR et al (2024) An overview of green synthesized silver nanoparticles towards bioactive antibacterial, antimicrobial and antifungal applications. Adv Colloid Interface Sci 323:103053","journal-title":"Adv Colloid Interface Sci"},{"issue":"1","key":"12599_CR29","first-page":"1","volume":"12","author":"PM Kustiawan","year":"2024","unstructured":"Kustiawan PM, Syaifie PH, Al Khairy Siregar KA, Ibadillah D, Mardliyati E (2024) New insights of propolis nanoformulation and its therapeutic potential in human diseases. ADMET DMPK 12(1):1\u201326","journal-title":"ADMET DMPK"},{"issue":"14","key":"12599_CR30","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1080\/17435889.2024.2343273","volume":"19","author":"SS Bokhari","year":"2024","unstructured":"Bokhari SS, Ali T, Naeem M, Hussain F, Nasir A (2024) Recent advances in nanoformulation-based delivery for cancer immunotherapy. Nanomedicine 19(14):1253\u20131269","journal-title":"Nanomedicine"},{"issue":"1","key":"12599_CR31","doi-asserted-by":"publisher","first-page":"2249628","DOI":"10.1080\/16583655.2023.2249628","volume":"17","author":"EN Ay","year":"2023","unstructured":"Ay EN, Caner A, \u00d6zsoy Hepokur C, Dani\u015fman Kalindemirta\u015f F, \u00d6zen Ero\u011flu G, Kariper \u0130A (2023) Propolis nanoparticles synthesis and characterization with cytotoxic and apoptotic effects on breast cancer cells. J Taibah Univ Sci 17(1):2249628","journal-title":"J Taibah Univ Sci"},{"issue":"04","key":"12599_CR32","doi-asserted-by":"publisher","first-page":"55","DOI":"10.4236\/anp.2019.84005","volume":"8","author":"JA Abdo","year":"2019","unstructured":"Abdo JA, Alsharif FM, Salah N, Elkhawaga OAY (2019) Cytotoxic effect of propolis nanoparticles on ehrlich ascites carcinoma bearing mice. Adv Nanopart 8(04):55","journal-title":"Adv Nanopart"},{"key":"12599_CR33","doi-asserted-by":"publisher","first-page":"113993","DOI":"10.1016\/j.ecoenv.2022.113993","volume":"243","author":"C Lu","year":"2022","unstructured":"Lu C, Lv Y, Kou G, Liu Y, Liu Y, Chen Y et al (2022) Silver nanoparticles induce developmental toxicity via oxidative stress and mitochondrial dysfunction in zebrafish (Danio rerio). Ecotoxicol Environ Saf 243:113993","journal-title":"Ecotoxicol Environ Saf"},{"issue":"1","key":"12599_CR34","doi-asserted-by":"publisher","first-page":"2743058","DOI":"10.1155\/2020\/2743058","volume":"2020","author":"X-s Jiang","year":"2020","unstructured":"Jiang X-s, Xie H-q, Li C-g, You M-m, Zheng Y-f, Li GQ et al (2020) Chinese propolis inhibits the proliferation of human gastric cancer cells by inducing apoptosis and cell cycle arrest. Evidence-Based Complement Altern Med 2020(1):2743058","journal-title":"Evidence-Based Complement Altern Med"},{"key":"12599_CR35","doi-asserted-by":"publisher","first-page":"101746","DOI":"10.1016\/j.toxrep.2024.101746","volume":"13","author":"S Srinivasan","year":"2024","unstructured":"Srinivasan S, Mohanprasanth A, Nadeem A, Saravanan M (2024) Exploring the anti-cancer and antimetastatic effect of Silymarin against lung cancer. Toxicol Rep 13:101746","journal-title":"Toxicol Rep"},{"key":"12599_CR36","doi-asserted-by":"publisher","first-page":"112364","DOI":"10.1016\/j.biopha.2021.112364","volume":"144","author":"H Liu","year":"2021","unstructured":"Liu H, Li J, Yuan W, Hao S, Wang M, Wang F et al (2021) Bioactive components and mechanisms of poplar propolis in inhibiting proliferation of human hepatocellular carcinoma HepG2 cells. Biomed Pharmacother 144:112364","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"12599_CR37","doi-asserted-by":"publisher","first-page":"3565","DOI":"10.3390\/ijms24043565","volume":"24","author":"C Ren","year":"2023","unstructured":"Ren C, Zhou P, Zhang M, Yu Z, Zhang X, Tombran-Tink J et al (2023) Molecular Mechanisms of Oxidative Stress Relief by CAPE in ARPE\u2009\u2013\u200919 Cells. Int J Mol Sci 24(4):3565","journal-title":"Int J Mol Sci"},{"issue":"4","key":"12599_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12668-025-02244-3","volume":"15","author":"M Aruchamy","year":"2025","unstructured":"Aruchamy M, Snega R, Surya M, Muthupandian S (2025) Exploring the Anticancer Effect of Reduced Graphene Oxide\u2013Titanium Dioxide (rGO-TiO\u2082) Nanocomposite against Oral Cancer. BioNanoScience 15(4):1\u201317","journal-title":"BioNanoScience"},{"issue":"6","key":"12599_CR39","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1093\/jpp\/rgad030","volume":"75","author":"IA Justino","year":"2023","unstructured":"Justino IA, Marincek A, Ferreira IR, Amaral RL, Fontanezi BB, Aldana-Mej\u00eda JA et al (2023) Brazilian red propolis extract free and encapsulated into polymeric nanoparticles against ovarian cancer: formulation, characterisation and biological assays in 2D and 3D models. J Pharm Pharmacol 75(6):806\u2013818","journal-title":"J Pharm Pharmacol"},{"key":"12599_CR40","doi-asserted-by":"publisher","first-page":"1217800","DOI":"10.3389\/fonc.2023.1217800","volume":"13","author":"F Ashoori","year":"2023","unstructured":"Ashoori F, Hajipour-Verdom B, Satari M, Abdolmaleki P (2023) Polyethylenimine-based iron oxide nanoparticles enhance cisplatin toxicity in ovarian cancer cells in the presence of a static magnetic field. Front Oncol 13:1217800","journal-title":"Front Oncol"},{"issue":"7","key":"12599_CR41","first-page":"30","volume":"7","author":"T Togan","year":"2015","unstructured":"Togan T, Evren E, Ciftci O, Narci H, Ozcan M, Arslan H (2015) The antibacterial effect of Propolis against clinical isolates. Blood 7(7):30","journal-title":"Blood"},{"key":"12599_CR42","doi-asserted-by":"publisher","first-page":"100479","DOI":"10.1016\/j.hermed.2021.100479","volume":"29","author":"VS Nandre","year":"2021","unstructured":"Nandre VS, Bagade AV, Kasote DM, Lee JH, Kodam KM, Kulkarni MV et al (2021) Antibacterial activity of Indian propolis and its lead compounds against multi-drug resistant clinical isolates. J Herb Med 29:100479","journal-title":"J Herb Med"},{"issue":"11","key":"12599_CR43","doi-asserted-by":"publisher","first-page":"739","DOI":"10.3390\/antibiotics9110739","volume":"9","author":"J-P Lavigne","year":"2020","unstructured":"Lavigne J-P, Ranfaing J, Dunyach-R\u00e9my C, Sotto A (2020) Synergistic effect of propolis and antibiotics on uropathogenic Escherichia coli. Antibiotics 9(11):739","journal-title":"Antibiotics"},{"key":"12599_CR44","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.fct.2017.03.052","volume":"107","author":"MR Neto","year":"2017","unstructured":"Neto MR, Tintino SR, da Silva ARP, do Socorro Costa M, Boligon AA, Matias EF et al (2017) Seasonal variation of Brazilian red propolis: Antibacterial activity, synergistic effect and phytochemical screening. Food Chem Toxicol 107:572\u2013580","journal-title":"Food Chem Toxicol"},{"issue":"2","key":"12599_CR45","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.burns.2014.07.014","volume":"41","author":"ME \u0141ysakowska","year":"2015","unstructured":"\u0141ysakowska ME, Ciebiada-Adamiec A, Klimek L, Sienkiewicz M (2015) The activity of silver nanoparticles (Axonnite) on clinical and environmental strains of Acinetobacter spp. Burns 41(2):364\u2013371","journal-title":"Burns"},{"issue":"1","key":"12599_CR46","doi-asserted-by":"publisher","first-page":"10751","DOI":"10.1038\/s41598-021-90208-4","volume":"11","author":"HF Hetta","year":"2021","unstructured":"Hetta HF, Al-Kadmy IM, Khazaal SS, Abbas S, Suhail A, El-Mokhtar MA et al (2021) Antibiofilm and antivirulence potential of silver nanoparticles against multidrug-resistant Acinetobacter baumannii. Sci Rep 11(1):10751","journal-title":"Sci Rep"},{"issue":"6","key":"12599_CR47","doi-asserted-by":"publisher","first-page":"3806","DOI":"10.1166\/jnn.2018.15013","volume":"18","author":"R Singh","year":"2018","unstructured":"Singh R, Vora J, Nadhe SB, Wadhwani SA, Shedbalkar UU, Chopade BA (2018) Antibacterial activities of bacteriagenic silver nanoparticles against nosocomial Acinetobacter baumannii. J Nanosci Nanotechnol 18(6):3806\u20133815","journal-title":"J Nanosci Nanotechnol"},{"key":"12599_CR48","doi-asserted-by":"publisher","unstructured":"Santos, R. P., Barros, J. D. S., Pereira, E. B., Oliveira, K. G. M., Brito, G. S., Costa, F. F., Fidelis, Q. C., Reis, A. S., Holanda, C. A., & Dutra, R. P. (2025). Brazilian Amazon red propolis as a sustainable resource for the green synthesis of antibacterial silver nanoparticles. J. biotech, 405, 263\u2013274. https:\/\/doi.org\/10.1016\/j.jbiotec.2025.05.018","DOI":"10.1016\/j.jbiotec.2025.05.018"},{"issue":"7","key":"12599_CR49","first-page":"453","volume":"65","author":"SO Mohamed","year":"2022","unstructured":"Mohamed SO, El-Naggar K, Khalil MM (2022) Green synthesis of silver nanoparticles using Egyptian propolis extract and its antimicrobial activity. Egypt J Chem 65(7):453\u2013464","journal-title":"Egypt J Chem"},{"issue":"4","key":"12599_CR50","doi-asserted-by":"publisher","first-page":"131","DOI":"10.34172\/ajcmi.3514","volume":"10","author":"Z Karimitabar","year":"2023","unstructured":"Karimitabar Z, Farmani A, Azimzadeh M, Alikhani MS, Shakib MM, Alikhani MY (2023) The antimicrobial activity of propolis ethanolic extract and silver nanoparticles synthesized by green method on gram-positive and negative bacteria. Avicenna J Clin Microbiol Infect 10(4):131\u2013136","journal-title":"Avicenna J Clin Microbiol Infect"},{"issue":"9","key":"12599_CR51","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.3390\/pharmaceutics14091853","volume":"14","author":"P Mendez-Pfeiffer","year":"2022","unstructured":"Mendez-Pfeiffer P, Ballesteros-Monrreal MG, Gaona-Ochoa J, Juarez J, Gastelum-Cabrera M, Monta\u00f1o-Leyva B et al (2022) Biosynthesis of silver nanoparticles using seasonal samples of sonoran desert propolis: Evaluation of its antibacterial activity against clinical isolates of multi-drug resistant bacteria. Pharmaceutics 14(9):1853","journal-title":"Pharmaceutics"},{"issue":"1","key":"12599_CR52","doi-asserted-by":"publisher","first-page":"15254","DOI":"10.1038\/s41598-022-19698-0","volume":"12","author":"SH Haji","year":"2022","unstructured":"Haji SH, Ali FA, Aka STH (2022) Synergistic antibacterial activity of silver nanoparticles biosynthesized by carbapenem-resistant Gram-negative bacilli. Sci Rep 12(1):15254","journal-title":"Sci Rep"},{"issue":"15","key":"12599_CR53","doi-asserted-by":"publisher","first-page":"4872","DOI":"10.3390\/molecules27154872","volume":"27","author":"AN Tamfu","year":"2022","unstructured":"Tamfu AN, Ceylan O, C\u00e2r\u00e2c G, Talla E, Dinica RM (2022) Antibiofilm and anti-quorum sensing potential of cycloartane-type triterpene acids from cameroonian grassland propolis: phenolic profile and antioxidant activity of crude extract. Molecules 27(15):4872","journal-title":"Molecules"},{"key":"12599_CR54","doi-asserted-by":"publisher","unstructured":"Solouki M, Moniri R, Fathizadeh H, Kashi FJ, Moosavi GA, Nazari-Alam A. (2021). Silver Nanoparticles: Green Synthesis Using Brain Heart Infusion Culture Medium and Evaluation of Antimicrobial and Antibiofilm Activity Against Acinetobacter baumannii. Medit. J. Infect. Microb. Antimicrob, 10(1), 50-50. https:\/\/doi.org\/10.4274\/mjima.galenos.2021.2021.50","DOI":"10.4274\/mjima.galenos.2021.2021.50"},{"issue":"1","key":"12599_CR55","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s13756-019-0533-3","volume":"8","author":"D Sharma","year":"2019","unstructured":"Sharma D, Misba L, Khan AU (2019) Antibiotics versus biofilm: an emerging battleground in microbial communities. Antimicrob Resist Infect Control 8(1):76","journal-title":"Antimicrob Resist Infect Control"},{"issue":"1","key":"12599_CR56","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1021\/acs.bioconjchem.9b00821","volume":"31","author":"S Bala Subramaniyan","year":"2019","unstructured":"Bala Subramaniyan S, Senthilnathan R, Arunachalam J, Anbazhagan V (2019) Revealing the significance of the glycan binding property of Butea monosperma seed lectin for enhancing the antibiofilm activity of silver nanoparticles against uropathogenic Escherichia coli. Bioconjug Chem 31(1):139\u2013148","journal-title":"Bioconjug Chem"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12599-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12599-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12599-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:04:32Z","timestamp":1786705472000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12599-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,14]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12599"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12599-9","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,14]]},"assertion":[{"value":"20 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"In the development of this manuscript, the authors employed Chat-GPT solely for linguistic refinement and readability improvement. The generated suggestions were carefully evaluated, revised where necessary, and fully validated by the authors. The authors assume complete responsibility for the scientific content, accuracy, and final form of the article.","order":4,"name":"Ethics","label":"AI and AI-assisted technologies in the writing process","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1404"}}