{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T13:26:25Z","timestamp":1786973185211,"version":"build-2736575974"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82203716"],"award-info":[{"award-number":["82203716"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82503422"],"award-info":[{"award-number":["82503422"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82373034"],"award-info":[{"award-number":["82373034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"\u201c13th Five-Year Plan\u201d Science and Education Strong Health Project Innovation Team of Yangzhou","award":["LJRC20181 and YZCXTD201801"],"award-info":[{"award-number":["LJRC20181 and YZCXTD201801"]}]},{"name":"Provincial-Level Discipline Leader of the NJPH","award":["DTRA202214"],"award-info":[{"award-number":["DTRA202214"]}]},{"name":"Cross-Cooperation Special Projects of the NJPH","award":["YJCHZ-2021-08"],"award-info":[{"award-number":["YJCHZ-2021-08"]}]},{"name":"Beiing iGanDan Foundation","award":["GDXZ-08-19"],"award-info":[{"award-number":["GDXZ-08-19"]}]},{"name":"Yangzhou Basic Research Program","award":["2024-3-02, 2025-1-02"],"award-info":[{"award-number":["2024-3-02, 2025-1-02"]}]},{"name":"Health research major project in Jiangsu Province","award":["K2023002"],"award-info":[{"award-number":["K2023002"]}]},{"name":"Postgraduate Research and Practice Innovation Program of Jiangsu Province","award":["KYCX23_3617"],"award-info":[{"award-number":["KYCX23_3617"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12605-0","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:47:02Z","timestamp":1786970822000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cuproptosis in hepatocellular carcinoma: bridging copper homeostasis with therapeutic horizons"],"prefix":"10.1007","volume":"53","author":[{"given":"Songsong","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoyuan","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbing","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjie","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dou-Sheng","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"12605_CR1","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1053\/j.gastro.2023.01.033","volume":"164","author":"MR Toh","year":"2023","unstructured":"Toh MR, Wong EYT, Wong SH et al (2023) Global Epidemiology and Genetics of Hepatocellular Carcinoma. Gastroenterology 164:766\u2013782. https:\/\/doi.org\/10.1053\/j.gastro.2023.01.033","journal-title":"Gastroenterology"},{"key":"12605_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.acr.2020.10.001","volume":"149","author":"S Chidambaranathan-Reghupaty","year":"2021","unstructured":"Chidambaranathan-Reghupaty S, Fisher PB, Sarkar D (2021) Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification. Adv Cancer Res 149:1\u201361. https:\/\/doi.org\/10.1016\/bs.acr.2020.10.001","journal-title":"Adv Cancer Res"},{"key":"12605_CR3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.21037\/cco-20-89","volume":"10","author":"W Chen","year":"2021","unstructured":"Chen W, Chiang CL, Dawson LA (2021) Efficacy and safety of radiotherapy for primary liver cancer. Chin Clin Oncol 10:9. https:\/\/doi.org\/10.21037\/cco-20-89","journal-title":"Chin Clin Oncol"},{"key":"12605_CR4","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1126\/science.abf0529","volume":"375","author":"P Tsvetkov","year":"2022","unstructured":"Tsvetkov P, Coy S, Petrova B et al (2022) Copper induces cell death by targeting lipoylated TCA cycle proteins. Science 375:1254\u20131261. https:\/\/doi.org\/10.1126\/science.abf0529","journal-title":"Science"},{"key":"12605_CR5","doi-asserted-by":"publisher","first-page":"114791","DOI":"10.1016\/j.biopha.2023.114791","volume":"163","author":"D Guan","year":"2023","unstructured":"Guan D, Zhao L, Shi X et al (2023) Copper in cancer: From pathogenesis to therapy. Biomed Pharmacother 163:114791. https:\/\/doi.org\/10.1016\/j.biopha.2023.114791","journal-title":"Biomed Pharmacother"},{"key":"12605_CR6","doi-asserted-by":"publisher","unstructured":"Springer C, Humayun D, Skouta R (2024) Cuproptosis: Unraveling the Mechanisms of Copper-Induced Cell Death and Its Implication in Cancer Therapy. Cancers (Basel) 16. https:\/\/doi.org\/10.3390\/cancers16030647","DOI":"10.3390\/cancers16030647"},{"key":"12605_CR7","doi-asserted-by":"publisher","first-page":"1236063","DOI":"10.3389\/fimmu.2023.1236063","volume":"14","author":"L Gao","year":"2023","unstructured":"Gao L, Zhang A (2023) Copper-instigated modulatory cell mortality mechanisms and progress in oncological treatment investigations. Front Immunol 14:1236063. https:\/\/doi.org\/10.3389\/fimmu.2023.1236063","journal-title":"Front Immunol"},{"key":"12605_CR8","doi-asserted-by":"publisher","first-page":"774","DOI":"10.5414\/cp202907","volume":"55","author":"T Li","year":"2017","unstructured":"Li T, Peng J, Zeng F et al (2017) Association between polymorphisms in CTR1, CTR2, ATP7A, and ATP7B and platinum resistance in epithelial ovarian cancer. Int J Clin Pharmacol Ther 55:774\u2013780. https:\/\/doi.org\/10.5414\/cp202907","journal-title":"Int J Clin Pharmacol Ther"},{"key":"12605_CR9","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.ctrv.2008.07.004","volume":"35","author":"A Gupte","year":"2009","unstructured":"Gupte A, Mumper RJ (2009) Elevated copper and oxidative stress in cancer cells as a target for cancer treatment. Cancer Treat Rev 35:32\u201346. https:\/\/doi.org\/10.1016\/j.ctrv.2008.07.004","journal-title":"Cancer Treat Rev"},{"key":"12605_CR10","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3184\/003685013x13712193905878","volume":"96","author":"R Purchase","year":"2013","unstructured":"Purchase R (2013) The link between copper and Wilson\u2019s disease. Sci Prog 96:213\u2013223. https:\/\/doi.org\/10.3184\/003685013x13712193905878","journal-title":"Sci Prog"},{"key":"12605_CR11","doi-asserted-by":"publisher","first-page":"118893","DOI":"10.1016\/j.bbamcr.2020.118893","volume":"1868","author":"VC Shanbhag","year":"2021","unstructured":"Shanbhag VC, Gudekar N, Jasmer K et al (2021) Copper metabolism as a unique vulnerability in cancer. Biochim Biophys Acta Mol Cell Res 1868:118893. https:\/\/doi.org\/10.1016\/j.bbamcr.2020.118893","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"12605_CR12","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1158\/1535-7163.Mct-23-0876","volume":"23","author":"L Song","year":"2024","unstructured":"Song L, Nguyen V, Xie J et al (2024) ATPase Copper Transporting Beta (ATP7B) Is a Novel Target for Improving the Therapeutic Efficacy of Docetaxel by Disulfiram\/Copper in Human Prostate Cancer. Mol Cancer Ther 23:854\u2013863. https:\/\/doi.org\/10.1158\/1535-7163.Mct-23-0876","journal-title":"Mol Cancer Ther"},{"key":"12605_CR13","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1007\/s10534-012-9528-8","volume":"25","author":"TZ Kidane","year":"2012","unstructured":"Kidane TZ, Farhad R, Lee KJ et al (2012) Uptake of copper from plasma proteins in cells where expression of CTR1 has been modulated. Biometals 25:697\u2013709. https:\/\/doi.org\/10.1007\/s10534-012-9528-8","journal-title":"Biometals"},{"key":"12605_CR14","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/s41556-021-00822-7","volume":"24","author":"A Das","year":"2022","unstructured":"Das A, Ash D, Fouda AY et al (2022) Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis. Nat Cell Biol 24:35\u201350. https:\/\/doi.org\/10.1038\/s41556-021-00822-7","journal-title":"Nat Cell Biol"},{"key":"12605_CR15","doi-asserted-by":"publisher","first-page":"25346","DOI":"10.1002\/anie.202108961","volume":"60","author":"L Chen","year":"2021","unstructured":"Chen L, Li N, Zhang M et al (2021) APEX2-based Proximity Labeling of Atox1 Identifies CRIP2 as a Nuclear Copper-binding Protein that Regulates Autophagy Activation. Angew Chem Int Ed Engl 60:25346\u201325355. https:\/\/doi.org\/10.1002\/anie.202108961","journal-title":"Angew Chem Int Ed Engl"},{"key":"12605_CR16","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1039\/c6mt00103c","volume":"8","author":"MC Linder","year":"2016","unstructured":"Linder MC (2016) Ceruloplasmin and other copper binding components of blood plasma and their functions: an update. Metallomics 8:887\u2013905. https:\/\/doi.org\/10.1039\/c6mt00103c","journal-title":"Metallomics"},{"key":"12605_CR17","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1111\/his.13314","volume":"71","author":"A Quaglia","year":"2017","unstructured":"Quaglia A, Bhathal PS (2017) Copper, copper-binding protein and cytokeratin 7 in biliary disorders. Histopathology 71:1006\u20131008. https:\/\/doi.org\/10.1111\/his.13314","journal-title":"Histopathology"},{"key":"12605_CR18","doi-asserted-by":"publisher","first-page":"124145","DOI":"10.1016\/j.envpol.2024.124145","volume":"352","author":"M Li","year":"2024","unstructured":"Li M, Tang S, Velkov T et al (2024) Copper exposure induces mitochondrial dysfunction and hepatotoxicity via the induction of oxidative stress and PERK\/ATF4 -mediated endoplasmic reticulum stress. Environ Pollut 352:124145. https:\/\/doi.org\/10.1016\/j.envpol.2024.124145","journal-title":"Environ Pollut"},{"key":"12605_CR19","doi-asserted-by":"publisher","first-page":"101264","DOI":"10.1016\/j.xcrm.2023.101264","volume":"4","author":"T Xing","year":"2023","unstructured":"Xing T, Li L, Chen Y et al (2023) Targeting the TCA cycle through cuproptosis confers synthetic lethality on ARID1A-deficient hepatocellular carcinoma. Cell Rep Med 4:101264. https:\/\/doi.org\/10.1016\/j.xcrm.2023.101264","journal-title":"Cell Rep Med"},{"key":"12605_CR20","doi-asserted-by":"publisher","first-page":"9325","DOI":"10.18632\/oncotarget.24282","volume":"9","author":"C Porcu","year":"2018","unstructured":"Porcu C, Antonucci L, Barbaro B et al (2018) Copper\/MYC\/CTR1 interplay: a dangerous relationship in hepatocellular carcinoma. Oncotarget 9:9325\u20139343. https:\/\/doi.org\/10.18632\/oncotarget.24282","journal-title":"Oncotarget"},{"key":"12605_CR21","doi-asserted-by":"publisher","first-page":"9834742","DOI":"10.1155\/2020\/9834742","volume":"2020","author":"K Zub\u010di\u0107","year":"2020","unstructured":"Zub\u010di\u0107 K, Radovanovi\u0107 V, Vlaini\u0107 J et al (2020) PI3K\/Akt and ERK1\/2 Signalling Are Involved in Quercetin-Mediated Neuroprotection against Copper-Induced Injury. Oxid Med Cell Longev 2020:9834742. https:\/\/doi.org\/10.1155\/2020\/9834742","journal-title":"Oxid Med Cell Longev"},{"key":"12605_CR22","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/j.tibs.2024.04.002","volume":"49","author":"CH Lin","year":"2024","unstructured":"Lin CH, Chin Y, Zhou M et al (2024) Protein lipoylation: mitochondria, cuproptosis, and beyond. Trends Biochem Sci 49:729\u2013744. https:\/\/doi.org\/10.1016\/j.tibs.2024.04.002","journal-title":"Trends Biochem Sci"},{"key":"12605_CR23","doi-asserted-by":"publisher","first-page":"134961","DOI":"10.1016\/j.scitotenv.2019.134961","volume":"708","author":"L Zeng","year":"2020","unstructured":"Zeng L, Ai CX, Zhang JS et al (2020) Pre-hypoxia exposure inhibited copper toxicity by improving energy metabolism, antioxidant defence and mitophagy in the liver of the large yellow croaker Larimichthys crocea. Sci Total Environ 708:134961. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.134961","journal-title":"Sci Total Environ"},{"key":"12605_CR24","doi-asserted-by":"publisher","first-page":"101912","DOI":"10.1016\/j.redox.2021.101912","volume":"41","author":"Q Luo","year":"2021","unstructured":"Luo Q, Song Y, Kang J et al (2021) mtROS-mediated Akt\/AMPK\/mTOR pathway was involved in Copper-induced autophagy and it attenuates Copper-induced apoptosis in RAW264.7 mouse monocytes. Redox Biol 41:101912. https:\/\/doi.org\/10.1016\/j.redox.2021.101912","journal-title":"Redox Biol"},{"key":"12605_CR25","doi-asserted-by":"publisher","first-page":"135039","DOI":"10.1016\/j.jhazmat.2024.135039","volume":"476","author":"W Gui","year":"2024","unstructured":"Gui W, Wang WX (2024) Copper redox state in cells and aquatic organisms: Implication for toxicity. J Hazard Mater 476:135039. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.135039","journal-title":"J Hazard Mater"},{"key":"12605_CR26","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1126\/science.abo3959","volume":"375","author":"MA Kahlson","year":"2022","unstructured":"Kahlson MA, Dixon SJ (2022) Copper-induced cell death. Science 375:1231\u20131232. https:\/\/doi.org\/10.1126\/science.abo3959","journal-title":"Science"},{"key":"12605_CR27","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/j.ccell.2025.02.015","volume":"43","author":"Z Yang","year":"2025","unstructured":"Yang Z, Su W, Wei X et al (2025) Hypoxia inducible factor-1\u03b1 drives cancer resistance to cuproptosis. Cancer Cell 43:937\u2013954. https:\/\/doi.org\/10.1016\/j.ccell.2025.02.015. .e9","journal-title":"Cancer Cell"},{"key":"12605_CR28","doi-asserted-by":"publisher","first-page":"3291","DOI":"10.2147\/ijn.S241157","volume":"15","author":"H He","year":"2020","unstructured":"He H, Zou Z, Wang B et al (2020) Copper Oxide Nanoparticles Induce Oxidative DNA Damage and Cell Death via Copper Ion-Mediated P38 MAPK Activation in Vascular Endothelial Cells. Int J Nanomed 15:3291\u20133302. https:\/\/doi.org\/10.2147\/ijn.S241157","journal-title":"Int J Nanomed"},{"key":"12605_CR29","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.4161\/cc.27922","volume":"13","author":"NS Kenneth","year":"2014","unstructured":"Kenneth NS, Hucks GE Jr., Kocab AJ et al (2014) Copper is a potent inhibitor of both the canonical and non-canonical NF\u03baB pathways. Cell Cycle 13:1006\u20131014. https:\/\/doi.org\/10.4161\/cc.27922","journal-title":"Cell Cycle"},{"key":"12605_CR30","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/s13578-023-01083-7","volume":"13","author":"EM Poursani","year":"2023","unstructured":"Poursani EM, Mercatelli D, Raninga P et al (2023) Copper chelation suppresses epithelial-mesenchymal transition by inhibition of canonical and non-canonical TGF-\u03b2 signaling pathways in cancer. Cell Biosci 13:132. https:\/\/doi.org\/10.1186\/s13578-023-01083-7","journal-title":"Cell Biosci"},{"key":"12605_CR31","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1080\/15548627.2023.2200554","volume":"19","author":"Q Xue","year":"2023","unstructured":"Xue Q, Kang R, Klionsky DJ et al (2023) Copper metabolism in cell death and autophagy. Autophagy 19:2175\u20132195. https:\/\/doi.org\/10.1080\/15548627.2023.2200554","journal-title":"Autophagy"},{"key":"12605_CR32","doi-asserted-by":"publisher","first-page":"925618","DOI":"10.3389\/fimmu.2022.925618","volume":"13","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, Zeng X, Wu Y et al (2022) Cuproptosis-Related Risk Score Predicts Prognosis and Characterizes the Tumor Microenvironment in Hepatocellular Carcinoma. Front Immunol 13:925618. https:\/\/doi.org\/10.3389\/fimmu.2022.925618","journal-title":"Front Immunol"},{"key":"12605_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-026-00964-6","author":"D Senft","year":"2026","unstructured":"Senft D (2026) Cuproptosis promotes antitumour immunity. Nat Rev Cancer. https:\/\/doi.org\/10.1038\/s41568-026-00964-6","journal-title":"Nat Rev Cancer"},{"issue":"Suppl 1","key":"12605_CR34","doi-asserted-by":"publisher","first-page":"S24","DOI":"10.1017\/s0007114507833046","volume":"98","author":"C Mu\u00f1oz","year":"2007","unstructured":"Mu\u00f1oz C, Rios E, Olivos J et al (2007) Iron, copper and immunocompetence. Br J Nutr 98(Suppl 1):S24\u2013S28. https:\/\/doi.org\/10.1017\/s0007114507833046","journal-title":"Br J Nutr"},{"key":"12605_CR35","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1007\/s10534-021-00318-9","volume":"34","author":"OP Ajsuvakova","year":"2021","unstructured":"Ajsuvakova OP, Skalnaya MG, Michalke B et al (2021) Alteration of iron (Fe), copper (Cu), zinc (Zn), and manganese (Mn) tissue levels and speciation in rats with desferioxamine-induced iron deficiency. Biometals 34:923\u2013936. https:\/\/doi.org\/10.1007\/s10534-021-00318-9","journal-title":"Biometals"},{"key":"12605_CR36","doi-asserted-by":"publisher","first-page":"191","DOI":"10.24425\/pjvs.2020.135816","volume":"24","author":"MM Jaafarzadeh","year":"2021","unstructured":"Jaafarzadeh MM, Ranji N, Aboutaleb E (2021) The effect of N-acetylcysteine on the levels of copper, zinc and expression of matrix metalloproteinases in the liver. Pol J Vet Sci 24:191\u2013199. https:\/\/doi.org\/10.24425\/pjvs.2020.135816","journal-title":"Pol J Vet Sci"},{"key":"12605_CR37","doi-asserted-by":"publisher","first-page":"4943","DOI":"10.1021\/acs.est.0c08609","volume":"55","author":"X Wei","year":"2021","unstructured":"Wei X, Hogstrand C, Chen G et al (2021) Zn Induces Lipophagy via the Deacetylation of Beclin1 and Alleviates Cu-Induced Lipotoxicity at Their Environmentally Relevant Concentrations. Environ Sci Technol 55:4943\u20134953. https:\/\/doi.org\/10.1021\/acs.est.0c08609","journal-title":"Environ Sci Technol"},{"key":"12605_CR38","doi-asserted-by":"publisher","unstructured":"El-Megharbel SM, Qahl SH, Alaryani FS et al (2022) Synthesis, Spectroscopic Studies for Five New Mg (II), Fe (III), Cu (II), Zn (II) and Se (IV) Ceftriaxone Antibiotic Drug Complexes and Their Possible Hepatoprotective and Antioxidant Capacities. Antibiot (Basel) 11. https:\/\/doi.org\/10.3390\/antibiotics11050547","DOI":"10.3390\/antibiotics11050547"},{"key":"12605_CR39","doi-asserted-by":"publisher","first-page":"863296","DOI":"10.3389\/fmolb.2022.863296","volume":"9","author":"NHO Harder","year":"2022","unstructured":"Harder NHO, Lee HP, Flood VJ et al (2022) Fatty Acid Uptake in Liver Hepatocytes Induces Relocalization and Sequestration of Intracellular Copper. Front Mol Biosci 9:863296. https:\/\/doi.org\/10.3389\/fmolb.2022.863296","journal-title":"Front Mol Biosci"},{"issue":"Suppl 1","key":"12605_CR40","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1111\/plb.13222","volume":"23","author":"M Tahjib-Ul-Arif","year":"2021","unstructured":"Tahjib-Ul-Arif M, Sohag AAM, Mostofa MG et al (2021) Comparative effects of ascobin and glutathione on copper homeostasis and oxidative stress metabolism in mitigation of copper toxicity in rice. Plant Biol (Stuttg) 23(Suppl 1):162\u2013169. https:\/\/doi.org\/10.1111\/plb.13222","journal-title":"Plant Biol (Stuttg)"},{"key":"12605_CR41","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1080\/00365513.2020.1864835","volume":"81","author":"M Dastych","year":"2021","unstructured":"Dastych M, Husov\u00e1 L, Aiglov\u00e1 K et al (2021) Manganese and copper levels in patients with primary biliary cirrhosis and primary sclerosing cholangitis. Scand J Clin Lab Invest 81:116\u2013120. https:\/\/doi.org\/10.1080\/00365513.2020.1864835","journal-title":"Scand J Clin Lab Invest"},{"key":"12605_CR42","doi-asserted-by":"publisher","first-page":"100613","DOI":"10.1016\/j.ctarc.2022.100613","volume":"32","author":"P Janardhanan","year":"2022","unstructured":"Janardhanan P, Somasundaran AK, Balakrishnan AJ et al (2022) Sensitization of cancer cells towards Cisplatin and Carboplatin by protein kinase D inhibitors through modulation of ATP7A\/B (copper transport ATPases). Cancer Treat Res Commun 32:100613. https:\/\/doi.org\/10.1016\/j.ctarc.2022.100613","journal-title":"Cancer Treat Res Commun"},{"key":"12605_CR43","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/j.drudis.2020.04.003","volume":"25","author":"H Li","year":"2020","unstructured":"Li H, Wang J, Wu C et al (2020) The combination of disulfiram and copper for cancer treatment. Drug Discov Today 25:1099\u20131108. https:\/\/doi.org\/10.1016\/j.drudis.2020.04.003","journal-title":"Drug Discov Today"},{"key":"12605_CR44","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1186\/s13046-022-02485-0","volume":"41","author":"P Zheng","year":"2022","unstructured":"Zheng P, Zhou C, Lu L et al (2022) Elesclomol: a copper ionophore targeting mitochondrial metabolism for cancer therapy. J Exp Clin Cancer Res 41:271. https:\/\/doi.org\/10.1186\/s13046-022-02485-0","journal-title":"J Exp Clin Cancer Res"},{"key":"12605_CR45","doi-asserted-by":"publisher","unstructured":"Shabaneh S, Berry EM, Imam A et al (2025) Hepatic Copper Accumulation Predicts Fibrosis Progression and Mortality in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Nutrients 17. https:\/\/doi.org\/10.3390\/nu17182923","DOI":"10.3390\/nu17182923"},{"key":"12605_CR46","doi-asserted-by":"publisher","first-page":"103007","DOI":"10.1016\/j.redox.2023.103007","volume":"69","author":"P Zhang","year":"2024","unstructured":"Zhang P, Zhou C, Ren X et al (2024) Inhibiting the compensatory elevation of xCT collaborates with disulfiram\/copper-induced GSH consumption for cascade ferroptosis and cuproptosis. Redox Biol 69:103007. https:\/\/doi.org\/10.1016\/j.redox.2023.103007","journal-title":"Redox Biol"},{"key":"12605_CR47","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.msec.2018.11.034","volume":"96","author":"HA Katouah","year":"2019","unstructured":"Katouah HA, Al-Fahemi JH, Elghalban MG et al (2019) Synthesis of new Cu(II)-benzohydrazide nanometer complexes, spectral, modeling, CT-DNA binding with potential anti-inflammatory and anti-allergic theoretical features. Mater Sci Eng C Mater Biol Appl 96:740\u2013756. https:\/\/doi.org\/10.1016\/j.msec.2018.11.034","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"12605_CR48","doi-asserted-by":"publisher","unstructured":"Han X, Zhang X, Liu Z et al (2025) Copper-Based Nanotubes That Enhance Starvation Therapy Through Cuproptosis for Synergistic Cancer Treatment. Adv Sci (Weinh) e04121. https:\/\/doi.org\/10.1002\/advs.202504121","DOI":"10.1002\/advs.202504121"},{"key":"12605_CR49","doi-asserted-by":"publisher","unstructured":"Zeng Y, Cao Y, Ren S et al (2025) Responsive ROS-Augmented Prodrug Hybridization Nanoassemblies for Multidimensionally Synergitic Treatment of Hepatocellular Carcinoma in Cascade Assaults. Adv Sci (Weinh) e2501420. https:\/\/doi.org\/10.1002\/advs.202501420","DOI":"10.1002\/advs.202501420"},{"key":"12605_CR50","doi-asserted-by":"publisher","first-page":"4059","DOI":"10.1016\/j.apsb.2024.05.029","volume":"14","author":"X Wu","year":"2024","unstructured":"Wu X, Bai Z, Wang H et al (2024) CRISPR-Cas9 gene editing strengthens cuproptosis\/chemodynamic\/ferroptosis synergistic cancer therapy. Acta Pharm Sin B 14:4059\u20134072. https:\/\/doi.org\/10.1016\/j.apsb.2024.05.029","journal-title":"Acta Pharm Sin B"},{"key":"12605_CR51","doi-asserted-by":"publisher","first-page":"325102","DOI":"10.1088\/1361-6528\/aac372","volume":"29","author":"M Banik","year":"2018","unstructured":"Banik M, Patra M, Dutta D et al (2018) A simple robust method of synthesis of copper-silver core-shell nano-particle: evaluation of its structural and chemical properties with anticancer potency. Nanotechnology 29:325102. https:\/\/doi.org\/10.1088\/1361-6528\/aac372","journal-title":"Nanotechnology"},{"key":"12605_CR52","doi-asserted-by":"publisher","first-page":"6860","DOI":"10.1021\/acs.langmuir.2c00155","volume":"38","author":"J Zhu","year":"2022","unstructured":"Zhu J, Li Q, Li X et al (2022) Simulated Enzyme Activity and Efficient Antibacterial Activity of Copper-Doped Single-Atom Nanozymes. Langmuir 38:6860\u20136870. https:\/\/doi.org\/10.1021\/acs.langmuir.2c00155","journal-title":"Langmuir"},{"key":"12605_CR53","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1016\/j.bbadis.2017.02.020","volume":"1863","author":"M Lenartowicz","year":"2017","unstructured":"Lenartowicz M, Starzy\u0144ski RR, Jo\u0144czy A et al (2017) Copper therapy reduces intravascular hemolysis and derepresses ferroportin in mice with mosaic mutation (Atp7a(mo-ms)): An implication for copper-mediated regulation of the Slc40a1 gene expression. Biochim Biophys Acta Mol Basis Dis 1863:1410\u20131421. https:\/\/doi.org\/10.1016\/j.bbadis.2017.02.020","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"12605_CR54","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1023\/a:1020707811707","volume":"16","author":"LA Videla","year":"2003","unstructured":"Videla LA, Fern\u00e1ndez V, Tapia G et al (2003) Oxidative stress-mediated hepatotoxicity of iron and copper: role of Kupffer cells. Biometals 16:103\u2013111. https:\/\/doi.org\/10.1023\/a:1020707811707","journal-title":"Biometals"},{"key":"12605_CR55","doi-asserted-by":"publisher","first-page":"12249","DOI":"10.1007\/s00432-023-05099-x","volume":"149","author":"S Xu","year":"2023","unstructured":"Xu S, Dong K, Gao R et al (2023) Cuproptosis-related signature for clinical prognosis and immunotherapy sensitivity in hepatocellular carcinoma. J Cancer Res Clin Oncol 149:12249\u201312263. https:\/\/doi.org\/10.1007\/s00432-023-05099-x","journal-title":"J Cancer Res Clin Oncol"},{"key":"12605_CR56","doi-asserted-by":"publisher","first-page":"990790","DOI":"10.3389\/fimmu.2022.990790","volume":"13","author":"X Peng","year":"2022","unstructured":"Peng X, Zhu J, Liu S et al (2022) Signature construction and molecular subtype identification based on cuproptosis-related genes to predict the prognosis and immune activity of patients with hepatocellular carcinoma. Front Immunol 13:990790. https:\/\/doi.org\/10.3389\/fimmu.2022.990790","journal-title":"Front Immunol"},{"key":"12605_CR57","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1016\/j.jhep.2022.01.009","volume":"76","author":"M Yang","year":"2022","unstructured":"Yang M, Wu X, Hu J et al (2022) COMMD10 inhibits HIF1\u03b1\/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma. J Hepatol 76:1138\u20131150. https:\/\/doi.org\/10.1016\/j.jhep.2022.01.009","journal-title":"J Hepatol"},{"key":"12605_CR58","doi-asserted-by":"publisher","unstructured":"Maryam T, Rana NF, Alshahrani SM et al (2023) Silymarin Encapsulated Liposomal Formulation: An Effective Treatment Modality against Copper Toxicity Associated Liver Dysfunction and Neurobehavioral Abnormalities in Wistar Rats. Molecules 28. https:\/\/doi.org\/10.3390\/molecules28031514","DOI":"10.3390\/molecules28031514"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12605-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12605-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12605-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:47:05Z","timestamp":1786970825000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12605-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12605"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12605-0","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]},"assertion":[{"value":"16 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Ethical approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors agree to submit and publish this manuscript.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1412"}}