{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:23:21Z","timestamp":1787315001674,"version":"build-2736575974"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100010598","name":"Universidade Federal Do Pampa","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010598","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Undergraduate students constitute a relevant population for investigating genetic and body weight-related factors associated with vitamin D deficiency. This study aimed to assess the associations of the VDR BsmI single nucleotide polymorphism (SNP) and body weight status, including obesity, with vitamin D deficiency in undergraduate students.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>This cross-sectional study included biochemical and genetic assessment conducted between April and May 2023. A total of 189 students were evaluated after excluding individuals who had received vitamin D supplementation within the six months preceding data collection. SNP genotyping was performed by qPCR using TaqMan probes, vitamin D levels were measured by chemiluminescent immunoassay, and body weight classification was determined according to World Health Organization (WHO) criteria. Vitamin D deficiency was observed in 34.9% of the participants. Individuals with vitamin D deficiency had significantly higher body weight, waist and hip circumference, and body fat percentage than those with sufficient vitamin D levels. The distributions of the BsmI genotypes and alleles differed significantly between the vitamin D groups. Multivariate logistic regression showed that obesity (OR\u2009=\u20094.260; 95% CI: 1.656\u201310.959) and the recessive genetic model (OR\u2009=\u20094.361; 95% CI: 1.200\u201315.846) were independently associated with vitamin D deficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Obesity and the VDR BsmI recessive genetic model were independently associated with higher odds of vitamin D deficiency in undergraduate students. These findings highlight the concurrent relevance of genetic and body weight-related factors to vitamin D status and support further research to inform preventive strategies in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11033-026-12633-w","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:27:50Z","timestamp":1787311670000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["VDR BsmI polymorphism and obesity in vitamin D deficiency among undergraduate students: a cross-sectional study"],"prefix":"10.1007","volume":"53","author":[{"given":"D\u00e9bora Alejandra Vasquez","family":"Rubio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle Castagnara","family":"Albuquerque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyana Feijo\u00f3","family":"Berro Pivetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren Alicia Flores Viera","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Rosa","family":"Retamoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helo\u00edsa Nogueira Pedra","family":"de Pellegrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Barbisan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matias Nunes","family":"Frizzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Pesarico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0328-446X","authenticated-orcid":false,"given":"Jacqueline","family":"da Costa Escobar Piccoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"12633_CR1","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1210\/clinem\/dgae290","volume":"109","author":"MB Demay","year":"2024","unstructured":"Demay MB, Pittas AG, Bikle DD, Diab DL, Kiely ME, Lazaretti-Castro M et al (2024) Vitamin D for the prevention of disease: an Endocrine Society clinical practice guideline. 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