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The present study evaluated the effects of dietary supplementation with\n                      <jats:italic>H. illucens<\/jats:italic>\n                      larval meal on body composition, biochemical parameters, and hepatic markers in mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Twenty Swiss mice (n = 10\/group) were randomly assigned to Control (AIN-93\u00a0M; mean initial body weight: 41.3\u00a0g) and AIN-93\u00a0M supplemented with 10%\n                      <jats:italic>H. illucens<\/jats:italic>\n                      larval meal (AIN-93\u00a0M + BSF; mean initial body weight: 39.6\u00a0g) for 12\u00a0weeks. When compared with controls, BSF-supplemented mice exhibited a 17.1% increase in body weight from baseline (final body weight: 46.36\u00a0g; p &lt; 0.0001), whereas control mice showed a 3.5% reduction (final body weight: 39.87\u00a0g). This increase was accompanied by greater lean and fat mass (p &lt; 0.05), while food intake and total body water remained unchanged (p &gt; 0.05). Serum biochemical parameters, including lipid profile, ALT, and AST, showed no significant differences between groups (p &gt; 0.05). Histological analysis revealed reduced hepatic lipid droplet area in BSF-supplemented mice (p &lt; 0.05). Additionally, hepatic TNF-\u03b1 expression was decreased (p &lt; 0.05), whereas FASN expression was not significantly altered (p &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present findings suggest that a 10% H. illucens larval meal modulates selected hepatic parameters by reducing lipid accumulation and inflammatory signaling under the conditions evaluated. Further studies are needed to clarify its long-term metabolic effects and potential applications as a sustainable dietary ingredient.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11033-026-12657-2","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:34:49Z","timestamp":1787913289000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary supplementation with black soldier fly (Hermetia illucens) larval meal modulates hepatic lipid homeostasis and reduces TNF-\u03b1 expression in mice"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7939-1685","authenticated-orcid":false,"given":"Lucas","family":"de Oliveira Ferreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8511-4028","authenticated-orcid":false,"given":"Magno Sim\u00e3o Silva","family":"Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0933-0847","authenticated-orcid":false,"given":"Katherine Costa Mello","family":"Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucyana Concei\u00e7\u00e3o","family":"Farias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Luiz Sena","family":"Guimaraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo Maur\u00edcio Batista","family":"de Paula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio S\u00e9rgio","family":"Barcala-Jorge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junio","family":"Cota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Marcus Oliveira","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7788-5447","authenticated-orcid":false,"given":"S\u00e9rgio Henrique Sousa","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"12657_CR1","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1146\/annurev-physiol-022724-105515","volume":"87","author":"M Dukewich","year":"2025","unstructured":"Dukewich M, Yuan L, Terrault NA (2025) At the crossroads of health and disease: consequences of fat in the liver. 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