{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T13:19:26Z","timestamp":1788441566522,"version":"build-2803163510"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["EMDR\/IG\/9\/2024-01026"],"award-info":[{"award-number":["EMDR\/IG\/9\/2024-01026"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12698-7","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T13:01:15Z","timestamp":1788440475000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fibroblast growth factors in Alzheimer\u2019s Disease pathogenesis: neuropharmacological implications for neuroprotection, neurogenesis, and therapeutic development"],"prefix":"10.1007","volume":"53","author":[{"given":"Jahnvi","family":"Sehgal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kajal","family":"Bagri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Deshmukh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"12698_CR1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s13195-017-0297-z","volume":"9","author":"M Crous-Bou","year":"2017","unstructured":"Crous-Bou M, Minguill\u00f3n C, Gramunt N, Molinuevo JL (2017) Alzheimer\u2019s disease prevention: from risk factors to early intervention. Alzheimers Res Ther 9:71","journal-title":"Alzheimers Res Ther"},{"key":"12698_CR2","first-page":"89","volume":"1","author":"S McGirr","year":"2020","unstructured":"McGirr S, Venegas C, Swaminathan A (2020) Alzheimers disease: A brief review. J Exp Neurol 1:89\u201398","journal-title":"J Exp Neurol"},{"key":"12698_CR3","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.bbadis.2016.01.013","volume":"1862","author":"LA Mohamed","year":"2016","unstructured":"Mohamed LA, Keller JN, Kaddoumi A (2016) Role of P-glycoprotein in mediating rivastigmine effect on amyloid-\u03b2 brain load and related pathology in Alzheimer\u2019s disease mouse model. Biochim Biophys Acta (BBA)-Molecular Basis Dis 1862:778\u2013787","journal-title":"Biochim Biophys Acta (BBA)-Molecular Basis Dis"},{"key":"12698_CR4","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.nic.2005.09.009","volume":"15","author":"BP Imbimbo","year":"2005","unstructured":"Imbimbo BP, Lombard J, Pomara N (2005) Pathophysiology of Alzheimer\u2019s disease. Neuroimaging Clin 15:727\u2013753","journal-title":"Neuroimaging Clin"},{"key":"12698_CR5","doi-asserted-by":"publisher","first-page":"6046","DOI":"10.1039\/C6RA26737H","volume":"7","author":"Z Liu","year":"2017","unstructured":"Liu Z, Zhang A, Sun H et al (2017) Two decades of new drug discovery and development for Alzheimer\u2019s disease. RSC Adv 7:6046\u20136058","journal-title":"RSC Adv"},{"key":"12698_CR6","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.bbadis.2009.10.006","volume":"1802","author":"PI Moreira","year":"2009","unstructured":"Moreira PI, Carvalho C, Zhu X et al (2009) Mitochondrial dysfunction is a trigger of Alzheimer\u2019s disease pathophysiology. Biochim Biophys Acta 1802:2\u201310. https:\/\/doi.org\/10.1016\/j.bbadis.2009.10.006","journal-title":"Biochim Biophys Acta"},{"key":"12698_CR7","doi-asserted-by":"publisher","first-page":"101619","DOI":"10.1016\/j.arr.2022.101619","volume":"77","author":"R Bai","year":"2022","unstructured":"Bai R, Guo J, Ye X-Y et al (2022) Oxidative stress: The core pathogenesis and mechanism of Alzheimer\u2019s disease. Ageing Res Rev 77:101619. https:\/\/doi.org\/10.1016\/j.arr.2022.101619","journal-title":"Ageing Res Rev"},{"key":"12698_CR8","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1016\/j.neurobiolaging.2007.12.005","volume":"30","author":"S Hauptmann","year":"2008","unstructured":"Hauptmann S, Scherping I, Dr\u00f6se S et al (2008) Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice. Neurobiol Aging 30:1574\u20131586. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2007.12.005","journal-title":"Neurobiol Aging"},{"key":"12698_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jnr.20093","volume":"77","author":"WJ Streit","year":"2004","unstructured":"Streit WJ (2004) Microglia and Alzheimer\u2019s disease pathogenesis. J Neurosci Res 77:1\u20138. https:\/\/doi.org\/10.1002\/jnr.20093","journal-title":"J Neurosci Res"},{"key":"12698_CR10","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1186\/s40001-025-02886-9","volume":"30","author":"J Zhang","year":"2025","unstructured":"Zhang J, Kong G, Yang J et al (2025) Pathological mechanisms and treatment progression of Alzheimer\u2019s disease. Eur J Med Res 30:625. https:\/\/doi.org\/10.1186\/s40001-025-02886-9","journal-title":"Eur J Med Res"},{"key":"12698_CR11","doi-asserted-by":"publisher","first-page":"1136266","DOI":"10.3389\/fnins.2023.1136266","volume":"17","author":"W Zhai","year":"2023","unstructured":"Zhai W, Zhang T, Jin Y et al (2023) The fibroblast growth factor system in cognitive disorders and dementia. Front Neurosci 17:1136266. https:\/\/doi.org\/10.3389\/fnins.2023.1136266","journal-title":"Front Neurosci"},{"key":"12698_CR12","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1002\/jcp.20302","volume":"204","author":"A Armand","year":"2005","unstructured":"Armand A, Pariset C, Laziz I et al (2005) FGF6 regulates muscle differentiation through a calcineurin-dependent pathway in regenerating soleus of adult mice. J Cell Physiol 204:297\u2013308","journal-title":"J Cell Physiol"},{"key":"12698_CR13","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.mehy.2012.12.008","volume":"80","author":"J-S Li","year":"2013","unstructured":"Li J-S, Yao Z-X (2013) Modulation of FGF receptor signaling as an intervention and potential therapy for myelin breakdown in Alzheimer\u2019s disease. Med Hypotheses 80:341\u2013344. https:\/\/doi.org\/10.1016\/j.mehy.2012.12.008","journal-title":"Med Hypotheses"},{"key":"12698_CR14","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a015958","author":"AA Belov","year":"2013","unstructured":"Belov AA, Mohammadi M (2013) Molecular mechanisms of fibroblast growth factor signaling in physiology and pathology. Cold Spring Harb Perspect Biol. https:\/\/doi.org\/10.1101\/cshperspect.a015958. 5:","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"12698_CR15","first-page":"298147","volume":"2012","author":"S Oulion","year":"2012","unstructured":"Oulion S, Bertrand S, Escriva H (2012) Evolution of the FGF gene family. Int J Evol Biol 2012:298147","journal-title":"Int J Evol Biol"},{"key":"12698_CR16","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/s41573-024-01125-w","volume":"24","author":"G Chen","year":"2025","unstructured":"Chen G, Chen L, Li X, Mohammadi M (2025) FGF-based drug discovery: advances and challenges. Nat Rev Drug Discov 24:335\u2013357","journal-title":"Nat Rev Drug Discov"},{"key":"12698_CR17","doi-asserted-by":"publisher","first-page":"34226","DOI":"10.1074\/jbc.M303183200","volume":"278","author":"SK Olsen","year":"2003","unstructured":"Olsen SK, Garbi M, Zampieri N et al (2003) Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs. J Biol Chem 278:34226\u201334236. https:\/\/doi.org\/10.1074\/jbc.M303183200","journal-title":"J Biol Chem"},{"key":"12698_CR18","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/nrd.2015.9","volume":"15","author":"C Degirolamo","year":"2016","unstructured":"Degirolamo C, Sabb\u00e0 C, Moschetta A (2016) Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23. Nat Rev Drug Discov 15:51\u201369","journal-title":"Nat Rev Drug Discov"},{"key":"12698_CR19","doi-asserted-by":"publisher","first-page":"154","DOI":"10.3389\/fendo.2015.00154","volume":"6","author":"N Itoh","year":"2015","unstructured":"Itoh N, Ohta H, Konishi M (2015) Endocrine FGFs: evolution, physiology, pathophysiology, and pharmacotherapy. Front Endocrinol (Lausanne) 6:154","journal-title":"Front Endocrinol (Lausanne)"},{"key":"12698_CR20","doi-asserted-by":"publisher","first-page":"2632","DOI":"10.1210\/en.2015-1109","volume":"156","author":"M S\u00e1rv\u00e1ri","year":"2015","unstructured":"S\u00e1rv\u00e1ri M, Kall\u00f3 I, Hrabovszky E et al (2015) Hippocampal gene expression is highly responsive to estradiol replacement in middle-aged female rats. Endocrinology 156:2632\u20132645","journal-title":"Endocrinology"},{"key":"12698_CR21","doi-asserted-by":"crossref","unstructured":"Santiago JA, Potashkin JA (2023) Biological and clinical implications of sex-specific differences in Alzheimer\u2019s disease. Sex Gend Eff Pharmacol 282:181\u2013197","DOI":"10.1007\/164_2023_672"},{"key":"12698_CR22","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1002\/dvdy.21388","volume":"237","author":"N Itoh","year":"2008","unstructured":"Itoh N, Ornitz DM (2008) Functional evolutionary history of the mouse Fgf gene family. Dev Dyn 237:18\u201327. https:\/\/doi.org\/10.1002\/dvdy.21388","journal-title":"Dev Dyn"},{"key":"12698_CR23","doi-asserted-by":"publisher","first-page":"E2665","DOI":"10.1073\/pnas.1521194113","volume":"113","author":"JL Pablo","year":"2016","unstructured":"Pablo JL, Wang C, Presby MM, Pitt GS (2016) Polarized localization of voltage-gated Na+ channels is regulated by concerted FGF13 and FGF14 action. Proc Natl Acad Sci 113:E2665\u2013E2674","journal-title":"Proc Natl Acad Sci"},{"key":"12698_CR24","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1007\/s10495-013-0886-7","volume":"18","author":"KH Tiong","year":"2013","unstructured":"Tiong KH, Mah LY, Leong C-O (2013) Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers. Apoptosis 18:1447\u20131468. https:\/\/doi.org\/10.1007\/s10495-013-0886-7","journal-title":"Apoptosis"},{"key":"12698_CR25","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1002\/(SICI)1520-6408(1998)22:4<374::AID-DVG7>3.0.CO;2-3","volume":"22","author":"P Kettunen","year":"1998","unstructured":"Kettunen P, Karavanova I, Thesleff I (1998) Responsiveness of developing dental tissues to fibroblast growth factors: expression of splicing alternatives of FGFR1, -2, -3, and of FGFR4; and stimulation of cell proliferation by FGF-2, -4, -8, and \u2013\u20099. Dev Genet 22:374\u2013385. https:\/\/doi.org\/10.1002\/(SICI)1520-6408(1998)22:4%3C374::AID-DVG7%3E3.0.CO;2-3","journal-title":"Dev Genet"},{"key":"12698_CR26","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1002\/1097-0045(20010201)46:2<163::aid-pros1020>3.0.co;2-t","volume":"46","author":"B Kwabi-Addo","year":"2001","unstructured":"Kwabi-Addo B, Ropiquet F, Giri D, Ittmann M (2001) Alternative splicing of fibroblast growth factor receptors in human prostate cancer. Prostate 46:163\u2013172. https:\/\/doi.org\/10.1002\/1097-0045(20010201)46:2%3C163::aid-pros1020%3E3.0.co;2-t","journal-title":"Prostate"},{"key":"12698_CR27","doi-asserted-by":"publisher","unstructured":"Hui Q, Jin Z, Li X et al (2018) FGF Family: From Drug Development to Clinical Application. Int J Mol Sci 19:1875 https:\/\/doi.org\/10.3390\/ijms19071875","DOI":"10.3390\/ijms19071875"},{"key":"12698_CR28","doi-asserted-by":"publisher","first-page":"3884","DOI":"10.1007\/s12035-021-02367-0","volume":"58","author":"L Klimaschewski","year":"2021","unstructured":"Klimaschewski L, Claus P (2021) Fibroblast Growth Factor Signalling in the Diseased Nervous System. Mol Neurobiol 58:3884\u20133902. https:\/\/doi.org\/10.1007\/s12035-021-02367-0","journal-title":"Mol Neurobiol"},{"key":"12698_CR29","doi-asserted-by":"publisher","first-page":"675725","DOI":"10.3389\/fphar.2021.675725","volume":"12","author":"Y Liu","year":"2021","unstructured":"Liu Y, Deng J, Liu Y et al (2021) FGF, Mechanism of Action, Role in Parkinson\u2019s Disease, and Therapeutics. Front Pharmacol 12:675725. https:\/\/doi.org\/10.3389\/fphar.2021.675725","journal-title":"Front Pharmacol"},{"key":"12698_CR30","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.1007\/s12035-020-02220-w","volume":"58","author":"IO Yusuf","year":"2021","unstructured":"Yusuf IO, Chen H-M, Cheng P-H et al (2021) Fibroblast Growth Factor 9 Stimulates Neuronal Length Through NF-kB Signaling in Striatal Cell Huntington\u2019s Disease Models. Mol Neurobiol 58:2396\u20132406. https:\/\/doi.org\/10.1007\/s12035-020-02220-w","journal-title":"Mol Neurobiol"},{"key":"12698_CR31","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/j.1471-4159.2004.02984.x","volume":"93","author":"P Cassina","year":"2005","unstructured":"Cassina P, Pehar M, Vargas MR et al (2005) Astrocyte activation by fibroblast growth factor-1 and motor neuron apoptosis: implications for amyotrophic lateral sclerosis. J Neurochem 93:38\u201346. https:\/\/doi.org\/10.1111\/j.1471-4159.2004.02984.x","journal-title":"J Neurochem"},{"key":"12698_CR32","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1097\/00001756-199504190-00015","volume":"6","author":"A Hanneken","year":"1995","unstructured":"Hanneken A, Frautschy S, Galasko D, Baird A (1995) A fibroblast growth factor binding protein in human cerebral spinal fluid. NeuroReport 6:886\u2013888. https:\/\/doi.org\/10.1097\/00001756-199504190-00015","journal-title":"NeuroReport"},{"key":"12698_CR33","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/s0361-9230(99)00188-4","volume":"51","author":"A Silva","year":"2000","unstructured":"Silva A, Montague JR, Lopez TF, Mudd LM (2000) Growth factor effects on survival and development of calbindin immunopositive cultured septal neurons. Brain Res Bull 51:35\u201342. https:\/\/doi.org\/10.1016\/s0361-9230(99)00188-4","journal-title":"Brain Res Bull"},{"key":"12698_CR34","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/0012-1606(92)90143-5","volume":"152","author":"J Engele","year":"1992","unstructured":"Engele J, Bohn MC (1992) Effects of acidic and basic fibroblast growth factors (aFGF, bFGF) on glial precursor cell proliferation: age dependency and brain region specificity. Dev Biol 152:363\u2013372. https:\/\/doi.org\/10.1016\/0012-1606(92)90143-5","journal-title":"Dev Biol"},{"key":"12698_CR35","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/0361-9230(94)90075-2","volume":"33","author":"K Sasaki","year":"1994","unstructured":"Sasaki K, Oomura Y, Figurov A, Yagi H (1994) Acidic fibroblast growth factor facilitates generation of long-term potentiation in rat hippocampal slices. Brain Res Bull 33:505\u2013511. https:\/\/doi.org\/10.1016\/0361-9230(94)90075-2","journal-title":"Brain Res Bull"},{"key":"12698_CR36","doi-asserted-by":"publisher","first-page":"10237","DOI":"10.1073\/pnas.88.22.10237","volume":"88","author":"AJ Bean","year":"1991","unstructured":"Bean AJ, Elde R, Cao YH et al (1991) Expression of acidic and basic fibroblast growth factors in the substantia nigra of rat, monkey, and human. Proc Natl Acad Sci U S A 88:10237\u201310241. https:\/\/doi.org\/10.1073\/pnas.88.22.10237","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12698_CR37","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.jocn.2009.05.037","volume":"17","author":"F Mashayekhi","year":"2010","unstructured":"Mashayekhi F, Hadavi M, Vaziri HR, Naji M (2010) Increased acidic fibroblast growth factor concentrations in the serum and cerebrospinal fluid of patients with Alzheimer\u2019s disease. J Clin Neurosci 17:357\u2013359. https:\/\/doi.org\/10.1016\/j.jocn.2009.05.037","journal-title":"J Clin Neurosci"},{"key":"12698_CR38","doi-asserted-by":"publisher","first-page":"32985","DOI":"10.1074\/jbc.M202803200","volume":"277","author":"M Hashimoto","year":"2002","unstructured":"Hashimoto M, Sagara Y, Langford D et al (2002) Fibroblast growth factor 1 regulates signaling via the glycogen synthase kinase-3beta pathway. Implications for neuroprotection. J Biol Chem 277:32985\u201332991. https:\/\/doi.org\/10.1074\/jbc.M202803200","journal-title":"J Biol Chem"},{"key":"12698_CR39","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1097\/00005072-199903000-00009","volume":"58","author":"V Thorns","year":"1999","unstructured":"Thorns V, Masliah E (1999) Evidence for neuroprotective effects of acidic fibroblast growth factor in Alzheimer disease. J Neuropathol Exp Neurol 58:296\u2013306. https:\/\/doi.org\/10.1097\/00005072-199903000-00009","journal-title":"J Neuropathol Exp Neurol"},{"key":"12698_CR40","doi-asserted-by":"publisher","first-page":"994","DOI":"10.21037\/atm-21-2492","volume":"9","author":"L Wang","year":"2021","unstructured":"Wang L, Jing R, Wang X et al (2021) A method for the expression of fibroblast growth factor 14 and assessment of its neuroprotective effect in an Alzheimer\u2019s disease model. Ann Transl Med 9:994. https:\/\/doi.org\/10.21037\/atm-21-2492","journal-title":"Ann Transl Med"},{"key":"12698_CR41","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1002\/glia.22413","volume":"60","author":"K Azim","year":"2012","unstructured":"Azim K, Raineteau O, Butt AM (2012) Intraventricular injection of FGF-2 promotes generation of oligodendrocyte-lineage cells in the postnatal and adult forebrain. Glia 60:1977\u20131990. https:\/\/doi.org\/10.1002\/glia.22413","journal-title":"Glia"},{"key":"12698_CR42","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s40035-023-00385-7","volume":"12","author":"P Zou","year":"2023","unstructured":"Zou P, Wu C, Liu TC-Y et al (2023) Oligodendrocyte progenitor cells in Alzheimer\u2019s disease: from physiology to pathology. Transl Neurodegener 12:52. https:\/\/doi.org\/10.1186\/s40035-023-00385-7","journal-title":"Transl Neurodegener"},{"key":"12698_CR43","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s13024-025-00861-w","volume":"20","author":"Z Huang","year":"2025","unstructured":"Huang Z, Zhang Y, Zou P et al (2025) Myelin dysfunction in aging and brain disorders: mechanisms and therapeutic opportunities. Mol Neurodegener 20:69. https:\/\/doi.org\/10.1186\/s13024-025-00861-w","journal-title":"Mol Neurodegener"},{"key":"12698_CR44","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1249\/MSS.0000000000003650","volume":"57","author":"C Wu","year":"2025","unstructured":"Wu C, Zou P, Zhu L et al (2025) Treadmill Exercise Mitigates Alzheimer\u2019s Pathology by Modulating Glial Polarization and Reducing Oligodendrocyte Precursor Cell Perivascular Clustering. Med Sci Sport Exerc 57:1148\u20131160. https:\/\/doi.org\/10.1249\/MSS.0000000000003650","journal-title":"Med Sci Sport Exerc"},{"key":"12698_CR45","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s12017-026-08905-0","volume":"28","author":"P Zou","year":"2026","unstructured":"Zou P, Huang Z, Zhang Y et al (2026) Myelin Lipid Reserves as a Conditional Metabolic Buffer: Implications for Alzheimer\u2019s Disease and Ischemic Stroke. Neuromolecular Med 28:7. https:\/\/doi.org\/10.1007\/s12017-026-08905-0","journal-title":"Neuromolecular Med"},{"key":"12698_CR46","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/0006-291x(90)91201-3","volume":"171","author":"EG Stopa","year":"1990","unstructured":"Stopa EG, Gonzalez AM, Chorsky R et al (1990) Basic fibroblast growth factor in Alzheimer\u2019s disease. Biochem Biophys Res Commun 171:690\u2013696. https:\/\/doi.org\/10.1016\/0006-291x(90)91201-3","journal-title":"Biochem Biophys Res Commun"},{"key":"12698_CR47","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1007\/s12640-018-9914-2","volume":"34","author":"M Amiri","year":"2018","unstructured":"Amiri M, Braidy N, Aminzadeh M (2018) Protective Effects of Fibroblast Growth Factor 21 Against Amyloid-Beta(1\u201342)-Induced Toxicity in SH-SY5Y Cells. Neurotox Res 34:574\u2013583. https:\/\/doi.org\/10.1007\/s12640-018-9914-2","journal-title":"Neurotox Res"},{"key":"12698_CR48","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1046\/j.1471-4159.2001.00315.x","volume":"77","author":"A Villa","year":"2001","unstructured":"Villa A, Latasa MJ, Pascual A (2001) Nerve growth factor modulates the expression and secretion of beta-amyloid precursor protein through different mechanisms in PC12 cells. J Neurochem 77:1077\u20131084. https:\/\/doi.org\/10.1046\/j.1471-4159.2001.00315.x","journal-title":"J Neurochem"},{"key":"12698_CR49","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1096\/fj.04-2114fje","volume":"18","author":"S Cantara","year":"2004","unstructured":"Cantara S, Donnini S, Morbidelli L et al (2004) Physiological levels of amyloid peptides stimulate the angiogenic response through FGF-2. FASEB J 18:1943\u20131945. https:\/\/doi.org\/10.1096\/fj.04-2114fje","journal-title":"FASEB J"},{"key":"12698_CR50","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.neurobiolaging.2018.12.019","volume":"76","author":"R Taipa","year":"2019","unstructured":"Taipa R, das Neves SP, Sousa AL et al (2019) Proinflammatory and anti-inflammatory cytokines in the CSF of patients with Alzheimer\u2019s disease and their correlation with cognitive decline. Neurobiol Aging 76:125\u2013132. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2018.12.019","journal-title":"Neurobiol Aging"},{"key":"12698_CR51","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.neurobiolaging.2014.10.004","volume":"36","author":"L Katsouri","year":"2014","unstructured":"Katsouri L, Ashraf A, Birch AM et al (2014) Systemic administration of fibroblast growth factor-2 (FGF2) reduces BACE1 expression and amyloid pathology in APP23 mice. Neurobiol Aging 36:821\u2013831. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2014.10.004","journal-title":"Neurobiol Aging"},{"key":"12698_CR52","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.stemcr.2016.12.007","volume":"8","author":"S Huang","year":"2017","unstructured":"Huang S, Mao J, Ding K et al (2017) Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer\u2019s Disease. Stem Cell Rep 8:84\u201394. https:\/\/doi.org\/10.1016\/j.stemcr.2016.12.007","journal-title":"Stem Cell Rep"},{"key":"12698_CR53","doi-asserted-by":"publisher","first-page":"E1339","DOI":"10.1073\/pnas.1102349108","volume":"108","author":"T Kiyota","year":"2011","unstructured":"Kiyota T, Ingraham KL, Jacobsen MT et al (2011) FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer\u2019s disease and has therapeutic implications for neurocognitive disorders. Proc Natl Acad Sci U S A 108:E1339\u2013E1348. https:\/\/doi.org\/10.1073\/pnas.1102349108","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12698_CR54","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s10020-024-00784-0","volume":"30","author":"X Xie","year":"2024","unstructured":"Xie X, Zhang X, Li S, Du W (2024) Involvement of Fgf2-mediated tau protein phosphorylation in cognitive deficits induced by sevoflurane in aged rats. Mol Med 30:39","journal-title":"Mol Med"},{"key":"12698_CR55","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3233\/JAD-190458","volume":"72","author":"Q Cao","year":"2019","unstructured":"Cao Q, Meng T, Man J et al (2019) aFGF promotes neurite growth by regulating GSK3\u03b2-CRMP2 signaling pathway in cortical neurons damaged by amyloid-\u03b2. J Alzheimer\u2019s Dis 72:97\u2013109","journal-title":"J Alzheimer\u2019s Dis"},{"key":"12698_CR56","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.bbi.2017.05.013","volume":"66","author":"M-M Tang","year":"2017","unstructured":"Tang M-M, Lin W-J, Zhang J-T et al (2017) Exogenous FGF2 reverses depressive-like behaviors and restores the suppressed FGF2-ERK1\/2 signaling and the impaired hippocampal neurogenesis induced by neuroinflammation. Brain Behav Immun 66:322\u2013331. https:\/\/doi.org\/10.1016\/j.bbi.2017.05.013","journal-title":"Brain Behav Immun"},{"key":"12698_CR57","doi-asserted-by":"publisher","first-page":"14367","DOI":"10.1007\/s12035-025-04962-x","volume":"62","author":"S Upadhayay","year":"2025","unstructured":"Upadhayay S, Soni D, Dhureja M et al (2025) Role of fibroblast growth factors in neurological disorders: insight into therapeutic approaches and molecular mechanisms. Mol Neurobiol 62:14367\u201314386","journal-title":"Mol Neurobiol"},{"key":"12698_CR58","doi-asserted-by":"publisher","first-page":"3103","DOI":"10.1007\/s11064-021-03418-7","volume":"46","author":"VK Sharma","year":"2021","unstructured":"Sharma VK, Singh TG, Singh S et al (2021) Apoptotic pathways and Alzheimer\u2019s disease: probing therapeutic potential. Neurochem Res 46:3103\u20133122","journal-title":"Neurochem Res"},{"key":"12698_CR59","doi-asserted-by":"publisher","first-page":"41230","DOI":"10.1074\/jbc.M111.270470","volume":"286","author":"M Lee","year":"2011","unstructured":"Lee M, Kang Y, Suk K et al (2011) Acidic fibroblast growth factor (FGF) potentiates glial-mediated neurotoxicity by activating FGFR2 IIIb protein. J Biol Chem 286:41230\u201341245. https:\/\/doi.org\/10.1074\/jbc.M111.270470","journal-title":"J Biol Chem"},{"key":"12698_CR60","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.freeradbiomed.2015.08.011","volume":"89","author":"J-I Chuang","year":"2015","unstructured":"Chuang J-I, Huang J-Y, Tsai S-J et al (2015) FGF9-induced changes in cellular redox status and HO-1 upregulation are FGFR-dependent and proceed through both ERK and AKT to induce CREB and Nrf2 activation. Free Radic Biol Med 89:274\u2013286. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2015.08.011","journal-title":"Free Radic Biol Med"},{"key":"12698_CR61","doi-asserted-by":"publisher","first-page":"154","DOI":"10.3389\/fphar.2020.00154","volume":"11","author":"X Wang","year":"2020","unstructured":"Wang X, Zhu L, Hu J et al (2020) FGF21 Attenuated LPS-Induced Depressive-Like Behavior via Inhibiting the Inflammatory Pathway. Front Pharmacol 11:154. https:\/\/doi.org\/10.3389\/fphar.2020.00154","journal-title":"Front Pharmacol"},{"key":"12698_CR62","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3389\/fnmol.2019.00328","volume":"12","author":"X Chen","year":"2020","unstructured":"Chen X, Li Z, Cheng Y et al (2020) Low and High Molecular Weight FGF-2 Have Differential Effects on Astrocyte Proliferation, but Are Both Protective Against A\u03b2-Induced Cytotoxicity. Front Mol Neurosci 12:328. https:\/\/doi.org\/10.3389\/fnmol.2019.00328","journal-title":"Front Mol Neurosci"},{"key":"12698_CR63","doi-asserted-by":"publisher","first-page":"4251","DOI":"10.1128\/mcb.13.7.4251-4259.1993","volume":"13","author":"M Miyamoto","year":"1993","unstructured":"Miyamoto M, Naruo K, Seko C et al (1993) Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property. Mol Cell Biol 13:4251\u20134259. https:\/\/doi.org\/10.1128\/mcb.13.7.4251-4259.1993","journal-title":"Mol Cell Biol"},{"key":"12698_CR64","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/s0006-8993(97)01340-1","volume":"783","author":"T Todo","year":"1998","unstructured":"Todo T, Kondo T, Nakamura S et al (1998) Neuronal localization of fibroblast growth factor-9 immunoreactivity in human and rat brain. Brain Res 783:179\u2013187. https:\/\/doi.org\/10.1016\/s0006-8993(97)01340-1","journal-title":"Brain Res"},{"key":"12698_CR65","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/s0006-8993(00)02563-4","volume":"876","author":"T Kanda","year":"2000","unstructured":"Kanda T, Iwasaki T, Nakamura S et al (2000) Self-secretion of fibroblast growth factor-9 supports basal forebrain cholinergic neurons in an autocrine\/paracrine manner. Brain Res 876:22\u201330. https:\/\/doi.org\/10.1016\/s0006-8993(00)02563-4","journal-title":"Brain Res"},{"key":"12698_CR66","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1523\/JNEUROSCI.17-07-02499.1997","volume":"17","author":"AM Fagan","year":"1997","unstructured":"Fagan AM, Suhr ST, Lucidi-Phillipi CA et al (1997) Endogenous FGF-2 is important for cholinergic sprouting in the denervated hippocampus. J Neurosci 17:2499\u20132511. https:\/\/doi.org\/10.1523\/JNEUROSCI.17-07-02499.1997","journal-title":"J Neurosci"},{"key":"12698_CR67","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1001\/jama.2023.11703","volume":"330","author":"GD Rabinovici","year":"2023","unstructured":"Rabinovici GD, La Joie R (2023) Amyloid-targeting monoclonal antibodies for Alzheimer disease. JAMA 330:507\u2013509","journal-title":"JAMA"},{"key":"12698_CR68","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1080\/17512433.2025.2556122","volume":"18","author":"E Francis","year":"2025","unstructured":"Francis E, Paylor S, Van C et al (2025) Review of anti-amyloid-beta (A\u03b2) monoclonal antibodies for the treatment of Alzheimer\u2019s disease. Expert Rev Clin Pharmacol 18:1063\u20131078","journal-title":"Expert Rev Clin Pharmacol"},{"key":"12698_CR69","doi-asserted-by":"publisher","first-page":"1247162","DOI":"10.3389\/fddev.2023.1247162","volume":"3","author":"X Zhang","year":"2023","unstructured":"Zhang X, Wang M, Liu Z et al (2023) Transnasal-brain delivery of nanomedicines for neurodegenerative diseases. Front Drug Deliv 3:1247162","journal-title":"Front Drug Deliv"},{"key":"12698_CR70","doi-asserted-by":"crossref","unstructured":"Xu H-L, Tian F-R, Xiao J et al (2018) Sustained-release of FGF-2 from a hybrid hydrogel of heparin-poloxamer and decellular matrix promotes the neuroprotective effects of proteins after spinal injury. Int J Nanomed 13:681\u2013694","DOI":"10.2147\/IJN.S152246"},{"key":"12698_CR71","doi-asserted-by":"publisher","first-page":"4743","DOI":"10.1007\/s12035-024-04549-y","volume":"62","author":"M Fang","year":"2025","unstructured":"Fang M, Lu L, Lou J et al (2025) FGF21 alleviates hypoxic-ischemic white matter injury in neonatal mice by mediating inflammation and oxidative stress through PPAR-\u03b3 signaling pathway. Mol Neurobiol 62:4743\u20134768","journal-title":"Mol Neurobiol"},{"key":"12698_CR72","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.ejphar.2012.09.020","volume":"695","author":"T Noshita","year":"2012","unstructured":"Noshita T, Murayama N, Oka T et al (2012) Effect of bFGF on neuronal damage induced by sequential treatment of amyloid \u03b2 and excitatory amino acid in vitro and in vivo. Eur J Pharmacol 695:76\u201382","journal-title":"Eur J Pharmacol"},{"key":"12698_CR73","doi-asserted-by":"publisher","first-page":"4125","DOI":"10.1073\/pnas.96.7.4125","volume":"96","author":"Q Guo","year":"1999","unstructured":"Guo Q, Sebastian L, Sopher BL et al (1999) Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation. Proc Natl Acad Sci 96:4125\u20134130","journal-title":"Proc Natl Acad Sci"},{"key":"12698_CR74","first-page":"2130","volume":"9","author":"S Chen","year":"2016","unstructured":"Chen S, Zheng Y, Xiao J et al (2016) FGF2 shows therapeutic effects in Alzheimer\u2019s disease animal model via suppressing PI3K\/Akt mediated ER stress. Int J Clin Exp Med 9:2130\u20132138","journal-title":"Int J Clin Exp Med"},{"key":"12698_CR75","doi-asserted-by":"publisher","first-page":"e13937","DOI":"10.1111\/acel.13937","volume":"22","author":"K Guo","year":"2023","unstructured":"Guo K, Huang W, Chen K et al (2023) Fibroblast growth factor 10 ameliorates neurodegeneration in mouse and cellular models of Alzheimer\u2019s disease via reducing tau hyperphosphorylation and neuronal apoptosis. Aging Cell 22:e13937","journal-title":"Aging Cell"},{"key":"12698_CR76","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.4103\/1673-5374.357902","volume":"18","author":"R-M Li","year":"2023","unstructured":"Li R-M, Xiao L, Zhang T et al (2023) Overexpression of fibroblast growth factor 13 ameliorates amyloid-\u03b2-induced neuronal damage. Neural Regen Res 18:1347\u20131353","journal-title":"Neural Regen Res"},{"key":"12698_CR77","doi-asserted-by":"publisher","first-page":"102367","DOI":"10.1016\/j.npep.2023.102367","volume":"101","author":"AC Ciltas","year":"2023","unstructured":"Ciltas AC, Karabulut S, Sahin B et al (2023) FGF-18 alleviates memory impairments and neuropathological changes in a rat model of Alzheimer\u2019s disease. Neuropeptides 101:102367","journal-title":"Neuropeptides"},{"key":"12698_CR78","doi-asserted-by":"publisher","first-page":"101133","DOI":"10.1016\/j.redox.2019.101133","volume":"22","author":"S Chen","year":"2019","unstructured":"Chen S, Chen S-T, Sun Y et al (2019) Fibroblast growth factor 21 ameliorates neurodegeneration in rat and cellular models of Alzheimer\u2019s disease. Redox Biol 22:101133","journal-title":"Redox Biol"},{"key":"12698_CR79","doi-asserted-by":"publisher","first-page":"8430","DOI":"10.7150\/thno.44370","volume":"10","author":"Y Sun","year":"2020","unstructured":"Sun Y, Wang Y, Chen S-T et al (2020) Modulation of the astrocyte-neuron lactate shuttle system contributes to neuroprotective action of fibroblast growth factor 21. Theranostics 10:8430","journal-title":"Theranostics"},{"key":"12698_CR80","doi-asserted-by":"publisher","first-page":"110439","DOI":"10.1016\/j.biopha.2020.110439","volume":"129","author":"K Kang","year":"2020","unstructured":"Kang K, Xu P, Wang M et al (2020) FGF21 attenuates neurodegeneration through modulating neuroinflammation and oxidant-stress. Biomed Pharmacother 129:110439","journal-title":"Biomed Pharmacother"},{"key":"12698_CR81","doi-asserted-by":"crossref","unstructured":"Alam R, Mrad Y, Hammoud H et al (2021) New insights into the role of fibroblast growth factors in Alzheimer\u2019s . Molecular Biology Reports 2: 1413-1427.","DOI":"10.1007\/s11033-021-06890-0"},{"key":"12698_CR82","doi-asserted-by":"crossref","unstructured":"Ali M, Timsina J, Xu Y et al (2026) Large-scale CSF and plasma proteomics reveal immune, synaptic, and extracellular matrix disruptions across neurodegenerative diseases. Neuron 14: 2549-2565.","DOI":"10.1016\/j.neuron.2026.02.035"},{"key":"12698_CR83","doi-asserted-by":"publisher","first-page":"1663276","DOI":"10.3389\/fnins.2025.1663276","volume":"19","author":"Y Zhao","year":"2025","unstructured":"Zhao Y, Wang X, Zhang J et al (2025) Plasma FGF2 and YAP1 as novel biomarkers for MCI in the elderly: analysis via bioinformatics and clinical study. Front Neurosci 19:1663276","journal-title":"Front Neurosci"},{"key":"12698_CR84","doi-asserted-by":"crossref","unstructured":"Qiao X, Yang M, Liu H et al (2026) Gut-brain axis-mediated mechanisms and immune regulatory pathways in vascular dementia: insights into microbiota-derived metabolites and novel therapeutic strategies. Behav Brain Res 505:116113","DOI":"10.1016\/j.bbr.2026.116113"},{"key":"12698_CR85","doi-asserted-by":"publisher","first-page":"712545","DOI":"10.3389\/fnagi.2021.712545","volume":"13","author":"L Shi","year":"2021","unstructured":"Shi L, Buckley NJ, Bos I et al (2021) Plasma proteomic biomarkers relating to Alzheimer\u2019s disease: a meta-analysis based on our own studies. Front Aging Neurosci 13:712545","journal-title":"Front Aging Neurosci"},{"key":"12698_CR86","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1007\/s12031-020-01600-0","volume":"70","author":"W Chen","year":"2020","unstructured":"Chen W, Wu L, Hu Y et al (2020) MicroRNA-107 ameliorates damage in a cell model of Alzheimer\u2019s disease by mediating the FGF7\/FGFR2\/PI3K\/Akt pathway. J Mol Neurosci 70:1589\u20131597","journal-title":"J Mol Neurosci"},{"key":"12698_CR87","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1093\/hmg\/ddab229","volume":"31","author":"Y Sun","year":"2022","unstructured":"Sun Y, Zhou D, Rahman MR et al (2022) A transcriptome-wide association study identifies novel blood-based gene biomarker candidates for Alzheimer\u2019s disease risk. Hum Mol Genet 31:289\u2013299","journal-title":"Hum Mol Genet"},{"key":"12698_CR88","doi-asserted-by":"publisher","first-page":"180185","DOI":"10.1038\/sdata.2018.185","volume":"5","author":"M Wang","year":"2018","unstructured":"Wang M, Beckmann ND, Roussos P et al (2018) The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer\u2019s disease. Sci data 5:180185","journal-title":"Sci data"},{"key":"12698_CR89","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1191\/1078155205jp159oa","volume":"11","author":"ML Radtke","year":"2005","unstructured":"Radtke ML, Kolesar JM (2005) Palifermin (Kepivance\u2122) for the treatment of oral mucositis in patients with hematologic malignancies requiring hematopoietic stem cell support. J Oncol Pharm Pract 11:121\u2013125","journal-title":"J Oncol Pharm Pract"},{"key":"12698_CR90","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.1742-4801.2006.00211.x","volume":"3","author":"MN Khan","year":"2006","unstructured":"Khan MN, Davies CG (2006) Advances in the management of leg ulcers\u2013the potential role of growth factors. Int Wound J 3:113\u2013122","journal-title":"Int Wound J"},{"key":"12698_CR91","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1002\/cpt.3606","volume":"117","author":"Y Wu","year":"2025","unstructured":"Wu Y, Dong P, Wu Q et al (2025) Insights into clinical trials for drugs targeting MASLD: progress, challenges, and future directions. Clin Pharmacol Ther 117:1614\u20131626","journal-title":"Clin Pharmacol Ther"},{"key":"12698_CR92","doi-asserted-by":"crossref","unstructured":"Gurevitz C, Rosenson RS (2024) Metabolic dysfunction\u2013associated steatotic liver disease, hypertriglyceridaemia, and cardiovascular risk. Eur J Prev Cardiol 4: zwae388","DOI":"10.1093\/eurjpc\/zwae388"},{"key":"12698_CR93","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/1742-2094-11-76","volume":"11","author":"M Noda","year":"2014","unstructured":"Noda M, Takii K, Parajuli B et al (2014) FGF-2 released from degenerating neurons exerts microglial-induced neuroprotection via FGFR3-ERK signaling pathway. J Neuroinflammation 11:76","journal-title":"J Neuroinflammation"},{"key":"12698_CR94","doi-asserted-by":"publisher","first-page":"2555","DOI":"10.2174\/1381612825666190716101411","volume":"25","author":"R Taliyan","year":"2019","unstructured":"Taliyan R, Chandran SK, Kakoty V (2019) Therapeutic approaches to Alzheimer\u2019s type of dementia: a focus on FGF21 mediated neuroprotection. Curr Pharm Des 25:2555\u20132568","journal-title":"Curr Pharm Des"},{"key":"12698_CR95","doi-asserted-by":"publisher","first-page":"P4","DOI":"10.1186\/2193-1801-4-S1-P4","volume":"4","author":"DO Borroto-Escuela","year":"2015","unstructured":"Borroto-Escuela DO, Narvaez M, Jim\u00e9nez-Beristain A et al (2015) Increase of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems via allosteric receptor-receptor interaction. Springerplus 4:P4","journal-title":"Springerplus"},{"key":"12698_CR96","unstructured":"Bova V (2024) Therapeutic approaches to counteract inflammation of Central Nervous System: role of SUN11602 in brain trauma and Parkinson. \u2019s disease and DdPAC light stimulation for Alzheimer\u2019s disease 500:14242."}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12698-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12698-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12698-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T13:01:19Z","timestamp":1788440479000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12698-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":96,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12698"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12698-7","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,3]]},"assertion":[{"value":"25 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1521"}}