{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:12:17Z","timestamp":1788779537938,"version":"build-2803163510"},"reference-count":102,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12722-w","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:53:30Z","timestamp":1788778410000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["UPS-mediated P-glycoprotein regulation in Alzheimer\u2019s disease: pharmacological implications for the amyloid pathology"],"prefix":"10.1007","volume":"53","author":[{"given":"Aditi","family":"Joshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jotiram","family":"Salunkhe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Ugale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"12722_CR1","doi-asserted-by":"publisher","DOI":"10.1101\/2025.05.29.656728","author":"M Collins","year":"2025","unstructured":"Collins M, Friedrich C, Elcheikhali M, Stewart P, Derks J, Connors-Stewart T, Altig K, Melloni A, Petelski A, Oakley D, Hyman B, Slavov N (2025) Ubiquitin-Proteasome system dysregulation in Alzheimer\u2019s disease impacts protein abundance. bioRxiv [Preprint]. https:\/\/doi.org\/10.1101\/2025.05.29.656728","journal-title":"bioRxiv [Preprint]"},{"key":"12722_CR2","doi-asserted-by":"publisher","first-page":"1730206","DOI":"10.3389\/fnagi.2025.1730206","volume":"17","author":"S Jia","year":"2025","unstructured":"Jia S, Li Q, Rui X, Qin W, Zhang W, Dou J, Zhang X (2025) The ubiquitin-proteasome system in Alzheimer\u2019s disease: mechanism of action and current status of treatment. Front Aging Neurosci 17:1730206. https:\/\/doi.org\/10.3389\/fnagi.2025.1730206","journal-title":"Front Aging Neurosci"},{"key":"12722_CR3","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.freeradbiomed.2021.07.002","volume":"172","author":"T Nakamura","year":"2021","unstructured":"Nakamura T, Oh C, Zhang X, Lipton SA (2021) Protein S-nitrosylation and oxidation contribute to protein misfolding in neurodegeneration. Free Radic Biol Med 172:562\u2013577. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2021.07.002","journal-title":"Free Radic Biol Med"},{"issue":"7","key":"12722_CR4","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1021\/mp200530q","volume":"9","author":"RS Omtri","year":"2012","unstructured":"Omtri RS, Davidson MW, Arumugam B, Poduslo JF, Kandimalla KK (2012) Differences in the cellular uptake and intracellular itineraries of amyloid beta proteins 40 and 42: Ramifications for the Alzheimer\u2019s drug discovery. Mol Pharm 9(7):1887\u20131897. https:\/\/doi.org\/10.1021\/mp200530q","journal-title":"Mol Pharm"},{"issue":"2","key":"12722_CR5","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3390\/biom13020313","volume":"13","author":"W Cai","year":"2023","unstructured":"Cai W, Wu T, Chen N (2023) The Amyloid-Beta clearance: from molecular targets to glial and neural cells. Biomolecules 13(2):313. https:\/\/doi.org\/10.3390\/biom13020313","journal-title":"Biomolecules"},{"issue":"6012","key":"12722_CR6","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1126\/science.1197623","volume":"330","author":"KG Mawuenyega","year":"2010","unstructured":"Mawuenyega KG, Sigurdson W, Ovod V, Munsell L, Kasten T, Morris JC, Yarasheski KE, Bateman RJ (2010) Decreased clearance of CNS \u0392-Amyloid in Alzheimer\u2019s disease. Science 330(6012):1774. https:\/\/doi.org\/10.1126\/science.1197623","journal-title":"Science"},{"issue":"1","key":"12722_CR7","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/s41392-024-01911-3","volume":"9","author":"J Zhang","year":"2024","unstructured":"Zhang J, Zhang Y, Wang J, Xia Y, Zhang J, Chen L (2024) Recent advances in Alzheimer\u2019s disease: mechanisms, clinical trials and new drug development strategies. Signal Transduct Target Therapy 9(1):211. https:\/\/doi.org\/10.1038\/s41392-024-01911-3","journal-title":"Signal Transduct Target Therapy"},{"issue":"1","key":"12722_CR8","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s12987-023-00492-7","volume":"20","author":"AS Hanafy","year":"2023","unstructured":"Hanafy AS, Lamprecht A, Dietrich D (2023) Local perfusion of capillaries reveals disrupted beta-amyloid homeostasis at the blood-brain barrier in Tg2576 murine Alzheimer\u2019s model. Fluids Barriers CNS 20(1):85. https:\/\/doi.org\/10.1186\/s12987-023-00492-7","journal-title":"Fluids Barriers CNS"},{"issue":"4","key":"12722_CR9","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1111\/febs.15148","volume":"287","author":"AB Chai","year":"2019","unstructured":"Chai AB, Leung GKF, Callaghan R, Gelissen IC (2019) P-glycoprotein: a role in the export of amyloid\u2010\u03b2 in Alzheimer\u2019s disease. FEBS J 287(4):612\u2013625. https:\/\/doi.org\/10.1111\/febs.15148","journal-title":"FEBS J"},{"issue":"22","key":"12722_CR10","doi-asserted-by":"publisher","first-page":"16288","DOI":"10.3390\/ijms242216288","volume":"24","author":"AE Alkhalifa","year":"2023","unstructured":"Alkhalifa AE, Al-Ghraiybah NF, Odum J, Shunnarah JG, Austin N, Kaddoumi A (2023) Blood\u2013Brain barrier breakdown in Alzheimer\u2019s disease: Mechanisms and targeted strategies. Int J Mol Sci 24(22):16288. https:\/\/doi.org\/10.3390\/ijms242216288","journal-title":"Int J Mol Sci"},{"issue":"1","key":"12722_CR11","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/ana.22310","volume":"69","author":"S Gandy","year":"2011","unstructured":"Gandy S, Wustman B (2011) New pathway links \u03b3-secretase to inflammation and memory while sparing notch. Ann Neurol 69(1):5\u20137. https:\/\/doi.org\/10.1002\/ana.22310","journal-title":"Ann Neurol"},{"key":"12722_CR12","doi-asserted-by":"publisher","first-page":"186","DOI":"10.3389\/fnagi.2018.00186","volume":"10","author":"AMS Hartz","year":"2018","unstructured":"Hartz AMS, Zhong Y, Shen AN, Abner EL, Bauer B (2018) Preventing P-GP ubiquitination lowers A\u0392 brain levels in an Alzheimer\u2019s disease mouse model. Front Aging Neurosci 10:186. https:\/\/doi.org\/10.3389\/fnagi.2018.00186","journal-title":"Front Aging Neurosci"},{"key":"12722_CR13","doi-asserted-by":"publisher","first-page":"1102809","DOI":"10.3389\/fnagi.2023.1102809","volume":"15","author":"JA Sousa","year":"2023","unstructured":"Sousa JA, Bernardes C, Bernardo-Castro S, Lino M, Albino I, Ferreira L, Br\u00e1s J, Guerreiro R, T\u00e1buas-Pereira M, Baldeiras I, Santana I, Sargento-Freitas J (2023) Reconsidering the role of blood-brain barrier in Alzheimer\u2019s disease: From delivery to target. Front Aging Neurosci 15:1102809. https:\/\/doi.org\/10.3389\/fnagi.2023.1102809","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"12722_CR14","doi-asserted-by":"publisher","first-page":"246","DOI":"10.3390\/ijms22010246","volume":"22","author":"AB Chai","year":"2020","unstructured":"Chai AB, Hartz AMS, Gao X, Yang A, Callaghan R, Gelissen IC (2020) New evidence for P-GP-Mediated export of amyloid-\u0392 peptides in molecular, Blood-Brain barrier and neuronal models. Int J Mol Sci 22(1):246. https:\/\/doi.org\/10.3390\/ijms22010246","journal-title":"Int J Mol Sci"},{"key":"12722_CR15","doi-asserted-by":"publisher","first-page":"2548","DOI":"10.1016\/j.csbj.2024.06.010","volume":"23","author":"A Elbahnsi","year":"2024","unstructured":"Elbahnsi A, Dudas B, Cisternino S, Decl\u00e8ves X, Miteva MA (2024) Mechanistic insights into P-glycoprotein ligand transport and inhibition revealed by enhanced molecular dynamics simulations. Comput Struct Biotechnol J 23:2548\u20132564. https:\/\/doi.org\/10.1016\/j.csbj.2024.06.010","journal-title":"Comput Struct Biotechnol J"},{"issue":"2","key":"12722_CR16","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1074\/jbc.m116.755884","volume":"292","author":"L Esser","year":"2016","unstructured":"Esser L, Zhou F, Pluchino KM, Shiloach J, Ma J, Tang W, Gutierrez C, Zhang A, Shukla S, Madigan JP, Zhou T, Kwong PD, Ambudkar SV, Gottesman MM, Xia D (2016) Structures of the multidrug transporter P-glycoprotein reveal asymmetric ATP binding and the mechanism of polyspecificity. J Biol Chem 292(2):446\u2013461. https:\/\/doi.org\/10.1074\/jbc.m116.755884","journal-title":"J Biol Chem"},{"key":"12722_CR17","doi-asserted-by":"publisher","DOI":"10.1101\/2025.06.15.659754","author":"SB Han","year":"2025","unstructured":"Han SB, Warwicker J, Fan H, Prince SM (2025) Nucleotide asymmetry and flexible linker dynamics modulate drug efflux cycle of P-glycoprotein, a computational study. bioRxiv [Preprint]. https:\/\/doi.org\/10.1101\/2025.06.15.659754","journal-title":"bioRxiv [Preprint]"},{"issue":"4","key":"12722_CR18","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1111\/j.1750-3639.2007.00075.x","volume":"17","author":"D Kuhnke","year":"2007","unstructured":"Kuhnke D, Jedlitschky G, Grube M, Krohn M, Jucker M, Mosyagin I, Cascorbi I, Walker LC, Kroemer HK, Warzok RW, Vogelgesang S (2007) MDR1-P\u2010Glycoprotein (ABCB1) mediates transport of Alzheimer\u2019s amyloid\u2010\u0392 Peptides\u2014Implications for the mechanisms of A\u0392 clearance at the Blood\u2013Brain barrier. Brain Pathol 17(4):347\u2013353. https:\/\/doi.org\/10.1111\/j.1750-3639.2007.00075.x","journal-title":"Brain Pathol"},{"issue":"11","key":"12722_CR19","doi-asserted-by":"publisher","first-page":"3285","DOI":"10.1172\/jci25247","volume":"115","author":"JR Cirrito","year":"2005","unstructured":"Cirrito JR (2005) P-glycoprotein deficiency at the blood-brain barrier increases amyloid-\u03b2 deposition in an Alzheimer disease mouse model. J Clin Invest 115(11):3285\u20133290. https:\/\/doi.org\/10.1172\/jci25247","journal-title":"J Clin Invest"},{"issue":"1","key":"12722_CR20","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1172\/JCI81108","volume":"126","author":"SE Storck","year":"2016","unstructured":"Storck SE, Meister S, Nahrath J, Mei\u00dfner JN, Schubert N, Di Spiezio A, Baches S, Vandenbroucke RE, Bouter Y, Prikulis I, Korth C, Weggen S, Heimann A, Schwaninger M, Bayer TA, Pietrzik CU (2016) Endothelial LRP1 transports amyloid-\u03b21\u201342 across the blood-brain barrier. J Clin Invest 126(1):123\u2013136. https:\/\/doi.org\/10.1172\/JCI81108","journal-title":"J Clin Invest"},{"key":"12722_CR21","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.bbi.2018.07.017","volume":"73","author":"SE Storck","year":"2018","unstructured":"Storck SE, Hartz AM, Bernard J, Wolf A, Kachlmeier A, Mahringer A, Weggen S, Pahnke J, Pietrzik CU (2018) The concerted amyloid-beta clearance of LRP1 and ABCB1\/P-gp across the blood-brain barrier is linked by PICALM. Brain Behav Immun 73:21\u201333. https:\/\/doi.org\/10.1016\/j.bbi.2018.07.017","journal-title":"Brain Behav Immun"},{"issue":"4","key":"12722_CR22","doi-asserted-by":"publisher","first-page":"e0250371","DOI":"10.1371\/journal.pone.0250371","volume":"16","author":"JW McCormick","year":"2021","unstructured":"McCormick JW, McCormick LA, Chen G, Vogel PD, Wise JG (2021) Transport of Alzheimer\u2019s associated amyloid-\u03b2 catalyzed by P-glycoprotein. PLoS ONE 16(4):e0250371. https:\/\/doi.org\/10.1371\/journal.pone.0250371","journal-title":"PLoS ONE"},{"key":"12722_CR23","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/s41392-025-02426-1","volume":"10","author":"J Chen","year":"2025","unstructured":"Chen J, Xiang P, Duro-Castano A, Cai H, Guo B, Liu X, Yu Y, Lui S, Luo K, Ke B, Ruiz-P\u00e9rez L, Gong Q, Tian X, Battaglia G (2025) Rapid amyloid-\u03b2 clearance and cognitive recovery through multivalent modulation of blood\u2013brain barrier transport. Signal Transduct Target Therapy 10:331. https:\/\/doi.org\/10.1038\/s41392-025-02426-1","journal-title":"Signal Transduct Target Therapy"},{"key":"12722_CR24","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13024-024-00716-w","volume":"19","author":"Q Ma","year":"2024","unstructured":"Ma Q, Zhang R, Wang F et al (2024) Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-\u03b242 by LRP1-dependent apolipoprotein E isoform-specific mechanism. Mol Neurodegeneration 19:27\u201340. https:\/\/doi.org\/10.1186\/s13024-024-00716-w","journal-title":"Mol Neurodegeneration"},{"issue":"7","key":"12722_CR25","doi-asserted-by":"publisher","first-page":"948","DOI":"10.3390\/pharmaceutics16070948","volume":"16","author":"S Petralla","year":"2024","unstructured":"Petralla S, Panayotova M, Franchina E, Fricker G, Puris E (2024) Low-density lipoprotein receptor-related protein 1 as a potential therapeutic target in Alzheimer\u2019s disease. Pharmaceutics 16(7):948. https:\/\/doi.org\/10.3390\/pharmaceutics16070948","journal-title":"Pharmaceutics"},{"issue":"1","key":"12722_CR26","doi-asserted-by":"publisher","first-page":"2495632","DOI":"10.1080\/17590914.2025.2495632","volume":"17","author":"J Asante","year":"2025","unstructured":"Asante J, Barger SW (2025) P-glycoprotein and Alzheimer\u2019s disease: threats and opportunities. ASN NEURO 17(1):2495632. https:\/\/doi.org\/10.1080\/17590914.2025.2495632","journal-title":"ASN NEURO"},{"issue":"9","key":"12722_CR27","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1007\/s00228-009-0709-5","volume":"65","author":"M Bauer","year":"2009","unstructured":"Bauer M, Karch R, Neumann F, Abrahim A, Wagner CC, Kletter K, M\u00fcller M, Zeitlinger M, Langer O (2009) Age dependency of cerebral P-gp function measured with (R)-[11\u00a0C] verapamil and PET. Eur J Clin Pharmacol 65(9):941\u2013946. https:\/\/doi.org\/10.1007\/s00228-009-0709-5","journal-title":"Eur J Clin Pharmacol"},{"issue":"9","key":"12722_CR28","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1016\/j.neurobiolaging.2015.05.020","volume":"36","author":"C Chiu","year":"2015","unstructured":"Chiu C, Miller MC, Monahan R, Osgood DP, Stopa EG, Silverberg GD (2015) P-glycoprotein expression and amyloid accumulation in human aging and Alzheimer\u2019s disease: preliminary observations. Neurobiol Aging 36(9):2475\u20132482. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2015.05.020","journal-title":"Neurobiol Aging"},{"issue":"6","key":"12722_CR29","doi-asserted-by":"publisher","first-page":"e1299","DOI":"10.1038\/cddis.2014.258","volume":"5","author":"R Park","year":"2014","unstructured":"Park R, Kook S, Park J, Mook-Jung I (2014) A\u03b21\u201342 reduces P-glycoprotein in the blood\u2013brain barrier through RAGE\u2013NF-\u03baB signaling. Cell Death Dis 5(6):e1299. https:\/\/doi.org\/10.1038\/cddis.2014.258","journal-title":"Cell Death Dis"},{"issue":"6","key":"12722_CR30","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1007\/s11307-012-0556-0","volume":"14","author":"DME Van Assema","year":"2012","unstructured":"Van Assema DME, Lubberink M, Boellaard R, Schuit RC, Windhorst AD, Scheltens P, Lammertsma AA, Van Berckel BN M (2012) P-Glycoprotein function at the Blood\u2013Brain barrier: Effects of age and gender. Mol Imaging Biology 14(6):771\u2013776. https:\/\/doi.org\/10.1007\/s11307-012-0556-0","journal-title":"Mol Imaging Biology"},{"issue":"3","key":"12722_CR31","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/s0026-895x(24)05623-2","volume":"66","author":"B Bauer","year":"2004","unstructured":"Bauer B, Hartz AM, Fricker G, Miller DS (2004) Pregnane X receptor up-regulation of P-Glycoprotein expression and transport function at the Blood-Brain barrier. Mol Pharmacol 66(3):413\u2013419. https:\/\/doi.org\/10.1016\/s0026-895x(24)05623-2","journal-title":"Mol Pharmacol"},{"issue":"6","key":"12722_CR32","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1038\/jcbfm.2008.16","volume":"28","author":"B Bauer","year":"2008","unstructured":"Bauer B, Hartz AMS, Lucking JR, Yang X, Pollack GM, Miller DS (2008) Coordinated nuclear receptor regulation of the Efflux Transporter, MRP2, and the Phase-II metabolizing Enzyme, GST\u03a0, at the Blood\u2014Brain barrier. J Cereb Blood Flow Metabolism 28(6):1222\u20131234. https:\/\/doi.org\/10.1038\/jcbfm.2008.16","journal-title":"J Cereb Blood Flow Metabolism"},{"issue":"1","key":"12722_CR33","doi-asserted-by":"publisher","first-page":"690121","DOI":"10.4061\/2011\/690121","volume":"2011","author":"A Brenn","year":"2011","unstructured":"Brenn A, Grube M, Peters M, Fischer A, Jedlitschky G, Kroemer HK, Warzok RW, Vogelgesang S (2011) Beta-Amyloid downregulates MDR1\u2010P\u2010Glycoprotein (ABCB1) expression at the Blood\u2010Brain barrier in mice. Int J Alzheimer\u2019s Disease 2011(1):690121. https:\/\/doi.org\/10.4061\/2011\/690121","journal-title":"Int J Alzheimer\u2019s Disease"},{"issue":"1","key":"12722_CR34","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s12964-023-01433-5","volume":"22","author":"M Pakjoo","year":"2024","unstructured":"Pakjoo M, Ahmadi SE, Zahedi M, Jaafari N, Khademi R, Amini A, Safa M (2024) Interplay between proteasome inhibitors and NF-\u03baB pathway in leukemia and lymphoma: a comprehensive review on challenges ahead of proteasome inhibitors. Cell Communication Signal 22(1):105. https:\/\/doi.org\/10.1186\/s12964-023-01433-5","journal-title":"Cell Communication Signal"},{"issue":"1","key":"12722_CR35","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","volume":"5","author":"H Yu","year":"2020","unstructured":"Yu H, Lin L, Zhang Z, Zhang H, Hu H (2020) Targeting NF-\u03baB pathway for the therapy of diseases: mechanism and clinical study. Signal Transduct Target Therapy 5(1):209. https:\/\/doi.org\/10.1038\/s41392-020-00312-6","journal-title":"Signal Transduct Target Therapy"},{"issue":"16","key":"12722_CR36","doi-asserted-by":"publisher","first-page":"8972","DOI":"10.3390\/ijms23168972","volume":"23","author":"E Sun","year":"2022","unstructured":"Sun E, Motolani A, Campos L, Lu T (2022) The pivotal role of NF-KB in the pathogenesis and therapeutics of Alzheimer\u2019s disease. Int J Mol Sci 23(16):8972. https:\/\/doi.org\/10.3390\/ijms23168972","journal-title":"Int J Mol Sci"},{"issue":"23","key":"12722_CR37","doi-asserted-by":"publisher","first-page":"eabk2252","DOI":"10.1126\/sciadv.abk2252","volume":"8","author":"ES Chocron","year":"2022","unstructured":"Chocron ES, Munk\u00e1csy E, Kim HS, Karpowicz P, Jiang N, Van Skike CE, DeRosa N, Banh AQ, Palavicini JP, Wityk P, Kalinowski L, Galvan V, Osmulski PA, Jankowska E, Gaczynska M, Pickering AM (2022) Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer\u2019s-like pathology in mouse and fly APP overexpression models. Sci Adv 8(23):eabk2252. https:\/\/doi.org\/10.1126\/sciadv.abk2252","journal-title":"Sci Adv"},{"issue":"10","key":"12722_CR38","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1021\/cn100067e","volume":"1","author":"X Zhao","year":"2010","unstructured":"Zhao X, Yang J (2010) Amyloid-\u0392 peptide is a substrate of the human 20S proteasome. ACS Chem Neurosci 1(10):655\u2013660. https:\/\/doi.org\/10.1021\/cn100067e","journal-title":"ACS Chem Neurosci"},{"issue":"1","key":"12722_CR39","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/s41420-024-02237-3","volume":"10","author":"B Qin","year":"2024","unstructured":"Qin B, Chen X, Wang F, Wang Y (2024) DUBs in Alzheimer\u2019s disease: mechanisms and therapeutic implications. Cell Death Discovery 10(1):475. https:\/\/doi.org\/10.1038\/s41420-024-02237-3","journal-title":"Cell Death Discovery"},{"issue":"2","key":"12722_CR40","doi-asserted-by":"publisher","first-page":"71","DOI":"10.2478\/jtim-2020-0012","volume":"8","author":"H Qian","year":"2020","unstructured":"Qian H, Zhang Y, Wu B, Wu S, You S, Zhang N, Sun Y (2020) Structure and function of HECT E3 ubiquitin ligases and their role in oxidative stress. J Translational Intern Med 8(2):71\u201379. https:\/\/doi.org\/10.2478\/jtim-2020-0012","journal-title":"J Translational Intern Med"},{"issue":"5","key":"12722_CR41","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1523\/jneurosci.2964-15.2016","volume":"36","author":"EM Rodrigues","year":"2016","unstructured":"Rodrigues EM, Scudder SL, Goo MS, Patrick GN (2016) A\u0392-Induced synaptic alterations require the E3 ubiquitin Ligase Nedd4-1. J Neurosci 36(5):1590\u20131595. https:\/\/doi.org\/10.1523\/jneurosci.2964-15.2016","journal-title":"J Neurosci"},{"issue":"3","key":"12722_CR42","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.3390\/ijms23031019","volume":"23","author":"AB Chai","year":"2022","unstructured":"Chai AB, Callaghan R, Gelissen IC (2022) The ubiquitin E3 ligase NEDD4 regulates the expression and amyloid-\u0392 peptide export activity of P-Glycoprotein. Int J Mol Sci 23(3):1019. https:\/\/doi.org\/10.3390\/ijms23031019","journal-title":"Int J Mol Sci"},{"issue":"1","key":"12722_CR43","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12987-021-00245-4","volume":"18","author":"Y Ding","year":"2021","unstructured":"Ding Y, Zhong Y, Baldeshwiler A, Abner EL, Bauer B, Hartz AMS (2021) Protecting P-glycoprotein at the blood\u2013brain barrier from degradation in an Alzheimer\u2019s disease mouse model. Fluids Barriers CNS 18(1):10. https:\/\/doi.org\/10.1186\/s12987-021-00245-4","journal-title":"Fluids Barriers CNS"},{"issue":"20","key":"12722_CR44","doi-asserted-by":"publisher","first-page":"8186","DOI":"10.1074\/jbc.m116.774554","volume":"292","author":"S Guntupalli","year":"2017","unstructured":"Guntupalli S, Jang SE, Zhu T, Huganir RL, Widagdo J, Anggono V (2017) GluA1 subunit ubiquitination mediates amyloid-\u03b2-induced loss of surface \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. J Biol Chem 292(20):8186\u20138194. https:\/\/doi.org\/10.1074\/jbc.m116.774554","journal-title":"J Biol Chem"},{"key":"12722_CR45","doi-asserted-by":"publisher","first-page":"916904","DOI":"10.3389\/fnagi.2022.916904","volume":"14","author":"P Suresh","year":"2022","unstructured":"Suresh P, Jasmin S, Yen Y, Hsu H, Varinthra P, Pairojana T, Chen C, Liu IY (2022) Attenuation of HECT-E3 ligase expression rescued memory deficits in 3xTg-AD mice. Front Aging Neurosci 14:916904. https:\/\/doi.org\/10.3389\/fnagi.2022.916904","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"12722_CR46","doi-asserted-by":"publisher","first-page":"253","DOI":"10.4103\/nrr.nrr-d-23-01277","volume":"20","author":"Z Hu","year":"2024","unstructured":"Hu Z, Yang J, Zhang S, Li M, Zuo C, Mao C, Zhang Z, Tang M, Shi C, Xu Y (2024) AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP\/PS1 mice. Neural Regeneration Res 20(1):253\u2013264. https:\/\/doi.org\/10.4103\/nrr.nrr-d-23-01277","journal-title":"Neural Regeneration Res"},{"issue":"5","key":"12722_CR47","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1111\/j.1471-4159.2005.03272.x","volume":"94","author":"N Sahara","year":"2005","unstructured":"Sahara N, Murayama M, Mizoroki T, Urushitani M, Imai Y, Takahashi R, Murata S, Tanaka K, Takashima A (2005) In vivo evidence of CHIP up-regulation attenuating tau aggregation. J Neurochem 94(5):1254\u20131263. https:\/\/doi.org\/10.1111\/j.1471-4159.2005.03272.x","journal-title":"J Neurochem"},{"issue":"4","key":"12722_CR48","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1111\/acel.12335","volume":"14","author":"AK Singh","year":"2015","unstructured":"Singh AK, Pati U (2015) CHIPstabilizes amyloid precursor protein via proteasomal degradation and p53-mediated trans\u2010repression of \u03b2\u2010secretase. Aging Cell 14(4):595\u2013604. https:\/\/doi.org\/10.1111\/acel.12335","journal-title":"Aging Cell"},{"issue":"2","key":"12722_CR49","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1177\/13872877251329540","volume":"105","author":"P Sordu","year":"2025","unstructured":"Sordu P, Alayl\u0131o\u011flu M, Samanc\u0131 B, Bulu E, G\u00fcle\u00e7 ZEK, Bilgi\u00e7 B, Hana\u011fas\u0131 HA, G\u00fcrvit \u0130H, Ulutin T, Dursun E, Gezen-Ak D (2025) Cerebrospinal fluid HSP90AA1, HSPA4, and STUB1\/CHIP levels in Alzheimer\u2019s disease, mild cognitive impairment, and frontotemporal dementia. J Alzheimer\u2019s Disease 105(2):481\u2013493. https:\/\/doi.org\/10.1177\/13872877251329540","journal-title":"J Alzheimer\u2019s Disease"},{"issue":"9","key":"12722_CR50","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/s41419-020-02953-5","volume":"11","author":"S Zhang","year":"2020","unstructured":"Zhang S, Hu Z, Mao C, Shi C, Xu Y (2020) CHIP as a therapeutic target for neurological diseases. Cell Death Dis 11(9):727. https:\/\/doi.org\/10.1038\/s41419-020-02953-5","journal-title":"Cell Death Dis"},{"issue":"12","key":"12722_CR51","doi-asserted-by":"publisher","first-page":"e1800240","DOI":"10.1002\/mnfr.201800240","volume":"62","author":"S Lee","year":"2018","unstructured":"Lee S, Choi B, Kim J, Kim J, LaFerla FM, Park JHY, Han J, Lee KW, Kim J, Kim J (2018) Sulforaphane upregulates the heat shock protein Co-Chaperone CHIP and clears amyloid\u2010\u0392 and TAU in a mouse model of Alzheimer\u2019s disease. Mol Nutr Food Res 62(12):e1800240. https:\/\/doi.org\/10.1002\/mnfr.201800240","journal-title":"Mol Nutr Food Res"},{"issue":"31","key":"12722_CR52","doi-asserted-by":"publisher","first-page":"6825","DOI":"10.1523\/jneurosci.0699-18.2018","volume":"38","author":"BN Lizama","year":"2018","unstructured":"Lizama BN, Palubinsky AM, Raveendran VA, Moore AM, Federspiel JD, Codreanu SG, Liebler DC, McLaughlin B (2018) Neuronal preconditioning requires the mitophagic activity of C-terminus of HSC70-Interacting protein. J Neurosci 38(31):6825\u20136840. https:\/\/doi.org\/10.1523\/jneurosci.0699-18.2018","journal-title":"J Neurosci"},{"key":"12722_CR53","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.freeradbiomed.2022.12.099","volume":"195","author":"Z Tang","year":"2022","unstructured":"Tang Z, Cao J, Yao J, Fan X, Zhao J, Zhao M, Duan Q, Han B, Duan S (2022) KDM1A-mediated upregulation of METTL3 ameliorates Alzheimer\u2019s disease via enhancing autophagic clearance of p-Tau through m6A-dependent regulation of STUB1. Free Radic Biol Med 195:343\u2013358. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.12.099","journal-title":"Free Radic Biol Med"},{"key":"12722_CR54","doi-asserted-by":"publisher","first-page":"126","DOI":"10.3389\/fncel.2018.00126","volume":"12","author":"HA Bustamante","year":"2018","unstructured":"Bustamante HA, Gonz\u00e1lez AE, Cerda-Troncoso C, Shaughnessy R, Otth C, Soza A, Burgos PV (2018) Interplay between the Autophagy-Lysosomal pathway and the Ubiquitin-Proteasome system: a target for therapeutic development in Alzheimer\u2019s disease. Front Cell Neurosci 12:126. https:\/\/doi.org\/10.3389\/fncel.2018.00126","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"12722_CR55","doi-asserted-by":"publisher","first-page":"5922","DOI":"10.1038\/s41467-023-41545-7","volume":"14","author":"I Maniv","year":"2023","unstructured":"Maniv I, Sarji M, Bdarneh A, Feldman A, Ankawa R, Koren E, Magid-Gold I, Reis N, Soteriou D, Salomon-Zimri S, Lavy T, Kesselman E, Koifman N, Kurz T, Kleifeld O, Michaelson D, Van Leeuwen FW, Verheijen BM, Fuchs Y, Glickman MH (2023) Altered ubiquitin signaling induces Alzheimer\u2019s disease-like hallmarks in a three-dimensional human neural cell culture model. Nat Commun 14(1):5922. https:\/\/doi.org\/10.1038\/s41467-023-41545-7","journal-title":"Nat Commun"},{"issue":"1","key":"12722_CR56","doi-asserted-by":"publisher","first-page":"8805","DOI":"10.1038\/srep08805","volume":"5","author":"ES Jung","year":"2015","unstructured":"Jung ES, Hong H, Kim C, Mook-Jung I (2015) Acute ER stress regulates amyloid precursor protein processing through ubiquitin-dependent degradation. Sci Rep 5(1):8805. https:\/\/doi.org\/10.1038\/srep08805","journal-title":"Sci Rep"},{"issue":"30","key":"12722_CR57","doi-asserted-by":"publisher","first-page":"15753","DOI":"10.1074\/jbc.m116.718023","volume":"291","author":"EFA Yeates","year":"2016","unstructured":"Yeates EFA, Tesco G (2016) The endosome-associated deubiquitinating enzyme USP8 regulates BACE1 enzyme ubiquitination and degradation. J Biol Chem 291(30):15753\u201315766. https:\/\/doi.org\/10.1074\/jbc.m116.718023","journal-title":"J Biol Chem"},{"key":"12722_CR58","doi-asserted-by":"publisher","unstructured":"Zheng Q, Song B, Li G, Cai F, Wu M, Zhao Y, Jiang L, Guo T, Shen M, Hou H, Zhou Y, Zhao Y, Di A, Zhang L, Zeng F, Zhang X, Luo H, Zhang X, Zhang H, Wang X (2022) USP25 inhibition ameliorates Alzheimer\u2019s pathology through the regulation of APP processing and A\u03b2 generation. J Clin Invest 132(5). https:\/\/doi.org\/10.1172\/jci152170","DOI":"10.1172\/jci152170"},{"issue":"21","key":"12722_CR59","doi-asserted-by":"publisher","first-page":"3913","DOI":"10.1016\/j.cell.2022.09.002","volume":"185","author":"Y Yan","year":"2022","unstructured":"Yan Y, Wang X, Chaput D, Shin M, Koh Y, Gan L, Pieper AA, Woo J, Kang DE (2022) X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women. Cell 185(21):3913\u20133930e19. https:\/\/doi.org\/10.1016\/j.cell.2022.09.002","journal-title":"Cell"},{"issue":"18","key":"12722_CR60","doi-asserted-by":"publisher","first-page":"9012","DOI":"10.3390\/ijms26189012","volume":"26","author":"E Porchietto","year":"2025","unstructured":"Porchietto E, Morello G, Cicilese G, Rainero I, Rubino E, Tamagno E, Boschi S, Guglielmotto M (2025) UCH-L1 in Alzheimer\u2019s Disease: a crucial player in Dementia-Associated mechanisms. Int J Mol Sci 26(18):9012. https:\/\/doi.org\/10.3390\/ijms26189012","journal-title":"Int J Mol Sci"},{"issue":"5","key":"12722_CR61","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1007\/s00401-016-1663-9","volume":"133","author":"P Wang","year":"2017","unstructured":"Wang P, Joberty G, Buist A, Vanoosthuyse A, Stancu I, Vasconcelos B, Pierrot N, Faelth-Savitski M, Kienlen-Campard P, Octave J, Bantscheff M, Drewes G, Moechars D, Dewachter I (2017) Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo. Acta Neuropathol 133(5):731\u2013749. https:\/\/doi.org\/10.1007\/s00401-016-1663-9","journal-title":"Acta Neuropathol"},{"issue":"6","key":"12722_CR62","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1016\/j.bbadis.2017.03.017","volume":"1863","author":"MJ Kiprowska","year":"2017","unstructured":"Kiprowska MJ, Stepanova A, Todaro DR, Galkin A, Haas A, Wilson SM, Figueiredo-Pereira ME (2017) Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer\u2019s disease. Biochim Et Biophys Acta (BBA) - Mol Basis Disease 1863(6):1157\u20131170. https:\/\/doi.org\/10.1016\/j.bbadis.2017.03.017","journal-title":"Biochim Et Biophys Acta (BBA) - Mol Basis Disease"},{"issue":"47","key":"12722_CR63","doi-asserted-by":"publisher","first-page":"19209","DOI":"10.1074\/jbc.m117.815126","volume":"292","author":"M Boselli","year":"2017","unstructured":"Boselli M, Lee B, Robert J, Prado MA, Min S, Cheng C, Silva MC, Seong C, Elsasser S, Hatle KM, Gahman TC, Gygi SP, Haggarty SJ, Gan L, King RW, Finley D (2017) An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. J Biol Chem 292(47):19209\u201319225. https:\/\/doi.org\/10.1074\/jbc.m117.815126","journal-title":"J Biol Chem"},{"key":"12722_CR64","doi-asserted-by":"publisher","first-page":"1124907","DOI":"10.3389\/fcell.2023.1124907","volume":"11","author":"K Davidson","year":"2023","unstructured":"Davidson K, Pickering AM (2023) The proteasome: A key modulator of nervous system function, brain aging, and neurodegenerative disease. Front Cell Dev Biology 11:1124907. https:\/\/doi.org\/10.3389\/fcell.2023.1124907","journal-title":"Front Cell Dev Biology"},{"issue":"5","key":"12722_CR65","doi-asserted-by":"publisher","first-page":"574","DOI":"10.3390\/antiox13050574","volume":"13","author":"R Sultana","year":"2024","unstructured":"Sultana R, Butterfield DA (2024) Protein oxidation in aging and Alzheimer\u2019s disease brain. Antioxidants 13(5):574. https:\/\/doi.org\/10.3390\/antiox13050574","journal-title":"Antioxidants"},{"key":"12722_CR66","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.freeradbiomed.2021.10.036","volume":"177","author":"DA Butterfield","year":"2021","unstructured":"Butterfield DA (2021) Ubiquitin carboxyl-terminal hydrolase L-1 in brain: Focus on its oxidative\/nitrosative modification and role in brains of subjects with Alzheimer disease and mild cognitive impairment. Free Radic Biol Med 177:278\u2013286. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2021.10.036","journal-title":"Free Radic Biol Med"},{"key":"12722_CR67","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.neulet.2019.03.016","volume":"703","author":"J Cao","year":"2019","unstructured":"Cao J, Zhong MB, Toro CA, Zhang L, Cai D (2019) Endo-lysosomal pathway and ubiquitin-proteasome system dysfunction in Alzheimer\u2019s disease pathogenesis. Neurosci Lett 703:68\u201378. https:\/\/doi.org\/10.1016\/j.neulet.2019.03.016","journal-title":"Neurosci Lett"},{"key":"12722_CR68","doi-asserted-by":"publisher","first-page":"320","DOI":"10.3389\/fnagi.2017.00320","volume":"9","author":"M Guglielmotto","year":"2017","unstructured":"Guglielmotto M, Monteleone D, Vasciaveo V, Repetto IE, Manassero G, Tabaton M, Tamagno E (2017) The decrease of UCH-L1 activity is a common mechanism responsible for A\u0392 42 accumulation in Alzheimer\u2019s and vascular disease. Front Aging Neurosci 9:320. https:\/\/doi.org\/10.3389\/fnagi.2017.00320","journal-title":"Front Aging Neurosci"},{"issue":"4","key":"12722_CR69","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s10571-015-0233-3","volume":"36","author":"Z Cai","year":"2015","unstructured":"Cai Z, Liu N, Wang C, Qin B, Zhou Y, Xiao M, Chang L, Yan L, Zhao B (2015) Role of RAGE in Alzheimer\u2019s Disease. Cell Mol Neurobiol 36(4):483\u2013495. https:\/\/doi.org\/10.1007\/s10571-015-0233-3","journal-title":"Cell Mol Neurobiol"},{"issue":"4","key":"12722_CR70","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1093\/brain\/awz011","volume":"142","author":"Y Yamazaki","year":"2019","unstructured":"Yamazaki Y, Shinohara M, Shinohara M, Yamazaki A, Murray ME, Liesinger AM, Heckman MG, Lesser ER, Parisi JE, Petersen RC, Dickson DW, Kanekiyo T, Bu G (2019) Selective loss of cortical endothelial tight junction proteins during Alzheimer\u2019s disease progression. Brain 142(4):1077\u20131092. https:\/\/doi.org\/10.1093\/brain\/awz011","journal-title":"Brain"},{"key":"12722_CR71","doi-asserted-by":"publisher","first-page":"435","DOI":"10.3389\/fncel.2018.00435","volume":"12","author":"C Evrard","year":"2018","unstructured":"Evrard C, Kienlen-Campard P, Coevoet M, Opsomer R, Tasiaux B, Melnyk P, Octave J, Bu\u00e9e L, Sergeant N, Vingtdeux V (2018) Contribution of the Endosomal-Lysosomal and proteasomal systems in amyloid-\u0392 precursor protein derived fragments processing. Front Cell Neurosci 12:435. https:\/\/doi.org\/10.3389\/fncel.2018.00435","journal-title":"Front Cell Neurosci"},{"key":"12722_CR72","doi-asserted-by":"publisher","first-page":"178310","DOI":"10.1016\/j.ejphar.2025.178310","volume":"1007","author":"T Gu","year":"2025","unstructured":"Gu T, Ma S, Liu W, Wang L (2025) Pregnane X receptor activation regulate amyloid transport to improve cognition functions in Alzheimer\u2019s disease. Eur J Pharmacol 1007:178310. https:\/\/doi.org\/10.1016\/j.ejphar.2025.178310","journal-title":"Eur J Pharmacol"},{"issue":"7","key":"12722_CR73","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.2967\/jnumed.119.237198","volume":"61","author":"V Zoufal","year":"2019","unstructured":"Zoufal V, Mairinger S, Brackhan M, Krohn M, Filip T, Sauberer M, Stanek J, Wanek T, Tournier N, Bauer M, Pahnke J, Langer O (2019) Imaging P-Glycoprotein Induction at the Blood\u2013Brain Barrier of a \u03b2-Amyloidosis Mouse Model with 11\u00a0C-Metoclopramide PET. J Nucl Med 61(7):1050\u20131057. https:\/\/doi.org\/10.2967\/jnumed.119.237198","journal-title":"J Nucl Med"},{"issue":"6","key":"12722_CR74","doi-asserted-by":"publisher","first-page":"656","DOI":"10.2174\/1567205013666161201201227","volume":"14","author":"S Bruckmann","year":"2017","unstructured":"Bruckmann S, Brenn A, Grube M, Niedrig K, Holtfreter S, Von Bohlen O, Groschup M, Keller M, Vogelgesang S (2017) Lack of P-glycoprotein Results in Impairment of Removal of Beta-Amyloid and Increased Intraparenchymal Cerebral Amyloid Angiopathy after Active Immunization in a Transgenic Mouse Model of Alzheimer\u2019s Disease. Curr Alzheimer Res 14(6):656\u2013667. https:\/\/doi.org\/10.2174\/1567205013666161201201227","journal-title":"Curr Alzheimer Res"},{"issue":"7","key":"12722_CR75","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.2967\/jnumed.113.130161","volume":"55","author":"AK Deo","year":"2014","unstructured":"Deo AK, Borson S, Link JM, Domino K, Eary JF, Ke B, Richards TL, Mankoff DA, Minoshima S, O\u2019Sullivan F, Eyal S, Hsiao P, Maravilla K, Unadkat JD (2014) Activity of P-Glycoprotein, a \u03b2-Amyloid Transporter at the Blood\u2013Brain Barrier, Is Compromised in Patients with Mild Alzheimer Disease. J Nucl Med 55(7):1106\u20131111. https:\/\/doi.org\/10.2967\/jnumed.113.130161","journal-title":"J Nucl Med"},{"issue":"8","key":"12722_CR76","doi-asserted-by":"publisher","first-page":"a006361","DOI":"10.1101\/cshperspect.a006361","volume":"2","author":"Y Ihara","year":"2012","unstructured":"Ihara Y, Morishima-Kawashima M, Nixon R (2012) The Ubiquitin-Proteasome system and the Autophagic-Lysosomal system in Alzheimer disease. Cold Spring Harbour Perspect Med 2(8):a006361. https:\/\/doi.org\/10.1101\/cshperspect.a006361","journal-title":"Cold Spring Harbour Perspect Med"},{"issue":"7","key":"12722_CR77","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1097\/00008571-200210000-00005","volume":"12","author":"S Vogelgesang","year":"2002","unstructured":"Vogelgesang S, Cascorbi I, Schroeder E, Pahnke J, Kroemer HK, Siegmund W, Kunert-Keil C, Walker LC, Warzok RW (2002) Deposition of Alzheimer\u2019s A\u03b2-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans. Pharmacogenetics 12(7):535\u2013541. https:\/\/doi.org\/10.1097\/00008571-200210000-00005","journal-title":"Pharmacogenetics"},{"key":"12722_CR78","doi-asserted-by":"publisher","first-page":"156229","DOI":"10.1016\/j.phymed.2024.156229","volume":"135","author":"C Zhu","year":"2024","unstructured":"Zhu C, Wang S, Ma S, Zhang S, Wang Y, Li B, Zhang W, Sun Z (2024) Gastrodin reduces A\u03b2 brain levels in an Alzheimer\u2019s disease mouse model by inhibiting P-glycoprotein ubiquitination. Phytomedicine 135:156229. https:\/\/doi.org\/10.1016\/j.phymed.2024.156229","journal-title":"Phytomedicine"},{"issue":"11","key":"12722_CR79","doi-asserted-by":"publisher","first-page":"168026","DOI":"10.1016\/j.jmb.2023.168026","volume":"435","author":"CM Nadel","year":"2023","unstructured":"Nadel CM, Thwin AC, Callahan M, Lee K, Connelly E, Craik CS, Southworth DR, Gestwicki JE (2023) The E3 ubiquitin ligase, CHIP\/STUB1, inhibits aggregation of phosphorylated proteoforms of microtubule-associated protein TAU (MAPT). J Mol Biol 435(11):168026. https:\/\/doi.org\/10.1016\/j.jmb.2023.168026","journal-title":"J Mol Biol"},{"issue":"1","key":"12722_CR80","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s12987-023-00470-z","volume":"20","author":"M Vulin","year":"2023","unstructured":"Vulin M, Zhong Y, Maloney BJ, Bauer B, Hartz AMS (2023) Proteasome inhibition protects blood\u2013brain barrier P-glycoprotein and lowers A\u03b2 brain levels in an Alzheimer\u2019s disease model. Fluids Barriers CNS 20(1):70. https:\/\/doi.org\/10.1186\/s12987-023-00470-z","journal-title":"Fluids Barriers CNS"},{"issue":"5","key":"12722_CR81","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1089\/ars.2011.3895","volume":"15","author":"A Carrano","year":"2011","unstructured":"Carrano A, Hoozemans JJ, Van Der Vies SM, Rozemuller AJ, Van Horssen J, De Vries HE (2011) Amyloid beta induces oxidative Stress-Mediated Blood\u2013Brain barrier changes in capillary amyloid angiopathy. Antioxid Redox Signal 15(5):1167\u20131178. https:\/\/doi.org\/10.1089\/ars.2011.3895","journal-title":"Antioxid Redox Signal"},{"key":"12722_CR82","doi-asserted-by":"publisher","first-page":"106125","DOI":"10.1016\/j.nbd.2023.106125","volume":"181","author":"YJ Shin","year":"2023","unstructured":"Shin YJ, Evitts KM, Jin S, Howard C, Sharp-Milgrom M, Schwarze-Taufiq T, Kinoshita C, Young JE, Zheng Y (2023) Amyloid beta peptides (A\u03b2) from Alzheimer\u2019s disease neuronal secretome induce endothelial activation in a human cerebral microvessel model. Neurobiol Dis 181:106125. https:\/\/doi.org\/10.1016\/j.nbd.2023.106125","journal-title":"Neurobiol Dis"},{"issue":"2","key":"12722_CR83","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3109\/09687688.2015.1023378","volume":"32","author":"BG Akkaya","year":"2015","unstructured":"Akkaya BG, Zolnerciks JK, Ritchie TK, Bauer B, Hartz AMS, Sullivan JA, Linton KJ (2015) The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1. Mol Membr Biol 32(2):39\u201345. https:\/\/doi.org\/10.3109\/09687688.2015.1023378","journal-title":"Mol Membr Biol"},{"key":"12722_CR84","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.freeradbiomed.2024.05.044","volume":"221","author":"F Hossen","year":"2024","unstructured":"Hossen F, Sun GY, Lee JC (2024) Oligomeric Tau-induced oxidative damage and functional alterations in cerebral endothelial cells: Role of RhoA\/ROCK signaling pathway. Free Radic Biol Med 221:261\u2013272. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2024.05.044","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"12722_CR85","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s13195-023-01258-x","volume":"15","author":"C Bianchi","year":"2023","unstructured":"Bianchi C, Alvarez-Castelao B, Sebasti\u00e1n-Serrano \u00c1, Di Lauro C, Soria-Tobar L, Nicke A, Engel T, D\u00edaz-Hern\u00e1ndez M (2023) P2X7 receptor inhibition ameliorates ubiquitin\u2013proteasome system dysfunction associated with Alzheimer\u2019s disease. Alzheimer\u2019s Res Therapy 15(1):105. https:\/\/doi.org\/10.1186\/s13195-023-01258-x","journal-title":"Alzheimer\u2019s Res Therapy"},{"issue":"2","key":"12722_CR86","doi-asserted-by":"publisher","first-page":"e23993","DOI":"10.4161\/tisb.23993","volume":"1","author":"S Kook","year":"2013","unstructured":"Kook S, Hong HS, Moon M, Mook-Jung I (2013) Disruption of blood-brain barrier in Alzheimer disease pathogenesis. Tissue Barriers 1(2):e23993. https:\/\/doi.org\/10.4161\/tisb.23993","journal-title":"Tissue Barriers"},{"issue":"3","key":"12722_CR87","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1111\/j.1532-5415.2004.52109.x","volume":"52","author":"MB Loeb","year":"2004","unstructured":"Loeb MB, Molloy DW, Smieja M, Standish T, Goldsmith CH, Mahony J, Smith S, Borrie M, Decoteau E, Davidson W, Mcdougall A, Gnarpe J, O\u2019donnell M, Chernesky M (2004) A Randomized, Controlled Trial of Doxycycline and Rifampin for Patients with Alzheimer\u2019s Disease. J Am Geriatr Soc 52(3):381\u2013387. https:\/\/doi.org\/10.1111\/j.1532-5415.2004.52109.x","journal-title":"J Am Geriatr Soc"},{"issue":"5","key":"12722_CR88","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1002\/gps.3846","volume":"28","author":"DW Molloy","year":"2012","unstructured":"Molloy DW, Standish T, Zhou Q, Guyatt G, Group DS (2012) A multicenter, blinded, randomized, factorial controlled trial of doxycycline and rifampin for treatment of Alzheimer\u2019s disease: the DARAD trial. Int J Geriatr Psychiatry 28(5):463\u2013470. https:\/\/doi.org\/10.1002\/gps.3846","journal-title":"Int J Geriatr Psychiatry"},{"issue":"1","key":"12722_CR89","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1124\/jpet.108.149690","volume":"329","author":"M Ott","year":"2009","unstructured":"Ott M, Fricker G, Bauer B (2009) Pregnane X Receptor (PXR) Regulates P-Glycoprotein at the Blood-Brain Barrier: Functional Similarities between Pig and Human PXR. J Pharmacol Exp Ther 329(1):141\u2013149. https:\/\/doi.org\/10.1124\/jpet.108.149690","journal-title":"J Pharmacol Exp Ther"},{"key":"12722_CR90","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.nbd.2019.01.020","volume":"125","author":"KH Elfakhri","year":"2019","unstructured":"Elfakhri KH, Abdallah IM, Brannen AD, Kaddoumi A (2019) Multi-faceted therapeutic strategy for treatment of Alzheimer\u2019s disease by concurrent administration of etodolac and \u03b1-tocopherol. Neurobiol Dis 125:123\u2013134. https:\/\/doi.org\/10.1016\/j.nbd.2019.01.020","journal-title":"Neurobiol Dis"},{"issue":"6","key":"12722_CR91","doi-asserted-by":"publisher","first-page":"2929","DOI":"10.3390\/ijms22062929","volume":"22","author":"J Kim","year":"2021","unstructured":"Kim J (2021) Pre-Clinical neuroprotective evidences and plausible mechanisms of sulforaphane in Alzheimer\u2019s disease. Int J Mol Sci 22(6):2929. https:\/\/doi.org\/10.3390\/ijms22062929","journal-title":"Int J Mol Sci"},{"issue":"11","key":"12722_CR92","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1586\/ern.09.86","volume":"9","author":"H-P Lee","year":"2009","unstructured":"Lee H-P, Casadesus G, Zhu X, Lee H-G, Perry G, Smith MA, Gustaw-Rothenberg K, Lerner A (2009) All-trans-retinoic acid as a novel therapeutic strategy for Alzheimer\u2019s disease. Expert Rev Neurother 9(11):1615\u20131621. https:\/\/doi.org\/10.1586\/ern.09.86","journal-title":"Expert Rev Neurother"},{"key":"12722_CR93","doi-asserted-by":"publisher","first-page":"4160","DOI":"10.1038\/srep04160","volume":"4","author":"ES Lippmann","year":"2014","unstructured":"Lippmann ES, Al-Ahmad A, Azarin SM, Palecek SP, Shusta EV (2014) A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources. Sci Rep 4:4160. https:\/\/doi.org\/10.1038\/srep04160","journal-title":"Sci Rep"},{"key":"12722_CR94","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s42826-022-00123-6","volume":"38","author":"J-B Kang","year":"2022","unstructured":"Kang J-B, Shah M-A, Park D-J, Koh P-O (2022) Retinoic acid regulates the ubiquitin\u2013proteasome system in a middle cerebral artery occlusion animal model. Lab Anim Res 38:15. https:\/\/doi.org\/10.1186\/s42826-022-00123-6","journal-title":"Lab Anim Res"},{"issue":"25","key":"12722_CR95","doi-asserted-by":"publisher","first-page":"8585","DOI":"10.1523\/jneurosci.2935-13.2014","volume":"34","author":"X Wang","year":"2014","unstructured":"Wang X, Campos CR, Peart JC, Smith LK, Boni JL, Cannon RE, Miller DS (2014) NRF2 upregulates ATP binding cassette transporter expression and activity at the Blood-Brain and Blood-Spinal cord barriers. J Neurosci 34(25):8585\u20138593. https:\/\/doi.org\/10.1523\/jneurosci.2935-13.2014","journal-title":"J Neurosci"},{"key":"12722_CR96","doi-asserted-by":"publisher","first-page":"1578138","DOI":"10.3389\/fncel.2025.1578138","volume":"19","author":"MS Khan","year":"2025","unstructured":"Khan MS, Qureshi N, Khan R, Son Y, Maqbool T (2025) CRISPR\/Cas9-Based therapeutics as a promising strategy for management of Alzheimer\u2019s disease: progress and prospects. Front Cell Neurosci 19:1578138. https:\/\/doi.org\/10.3389\/fncel.2025.1578138","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"12722_CR97","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1186\/s12964-024-01872-8","volume":"22","author":"S Zheng","year":"2024","unstructured":"Zheng S, Zhu J, Wang C, Wu Y, Sun S, Guo H, Chang Y, Ma R, Li G (2024b) USP9X-mediated deubiquitination of Raptor contributes to autophagy impairment and memory deficits in P301S mice. Cell Communication Signal 22(1):516. https:\/\/doi.org\/10.1186\/s12964-024-01872-8","journal-title":"Cell Communication Signal"},{"issue":"1","key":"12722_CR98","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/s41392-022-00999-9","volume":"7","author":"M He","year":"2022","unstructured":"He M, Cao C, Ni Z, Liu Y, Song P, Hao S, He Y, Sun X, Rao Y (2022) PROTACs: great opportunities for academia and industry (an update from 2020 to 2021). Signal Transduct Target Therapy 7(1):181. https:\/\/doi.org\/10.1038\/s41392-022-00999-9","journal-title":"Signal Transduct Target Therapy"},{"key":"12722_CR99","doi-asserted-by":"publisher","first-page":"1351792","DOI":"10.3389\/fphar.2024.1351792","volume":"15","author":"D Yao","year":"2024","unstructured":"Yao D, Li T, Yu L, Hu M, He Y, Zhang R, Wu J, Li S, Kuang W, Yang X, Liu G, Xie Y (2024) Selective degradation of hyperphosphorylated tau by proteolysis-targeting chimeras ameliorates cognitive function in Alzheimer\u2019s disease model mice. Front Pharmacol 15:1351792. https:\/\/doi.org\/10.3389\/fphar.2024.1351792","journal-title":"Front Pharmacol"},{"key":"12722_CR100","doi-asserted-by":"publisher","DOI":"10.1101\/2023.12.29.573648","author":"S Jung","year":"2023","unstructured":"Jung S, Roy R, Wang X, Liu B, Jaiswal N, Rai RK, Takagi Y, Gao C, Zeng L, Lo H, Wohlford RK, Higgins RK, Shekhar A, Bellail AC, Hao C (2023) Molecular glue degraders enhance CAPRIN1-dependent lysosomal degradation of APP in Alzheimer\u2019s disease. bioRxiv [Preprint]. https:\/\/doi.org\/10.1101\/2023.12.29.573648","journal-title":"bioRxiv [Preprint]"},{"issue":"11","key":"12722_CR101","doi-asserted-by":"publisher","first-page":"5279","DOI":"10.7150\/thno.55680","volume":"11","author":"W Wang","year":"2021","unstructured":"Wang W, Zhou Q, Jiang T, Li S, Ye J, Zheng J, Wang X, Liu Y, Deng M, Ke D, Wang Q, Wang Y, Wang J (2021) A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models. Theranostics 11(11):5279\u20135295. https:\/\/doi.org\/10.7150\/thno.55680","journal-title":"Theranostics"},{"issue":"1","key":"12722_CR102","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s12951-025-03109-3","volume":"23","author":"Y Jang","year":"2025","unstructured":"Jang Y, Kang S, Park HS, Lee D, Kim JH, Kim J, Kim D, Chung C, Yoon J, Bhang SH (2025) Drug delivery strategies with lipid-based nanoparticles for Alzheimer\u2019s disease treatment. J Nanobiotechnol 23(1):99. https:\/\/doi.org\/10.1186\/s12951-025-03109-3","journal-title":"J Nanobiotechnol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12722-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12722-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12722-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:53:31Z","timestamp":1788778411000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12722-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,7]]},"references-count":102,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12722"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12722-w","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,7]]},"assertion":[{"value":"22 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1547"}}