{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:07:49Z","timestamp":1788872869630,"version":"build-2803163510"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Near East University","award":["-"],"award-info":[{"award-number":["-"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12726-6","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:21:24Z","timestamp":1788870084000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular characterization of carbapenem resistance and hypervirulence determinants of Klebsiella pneumoniae circulating in a tertiary hospital in Cyprus"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4109-654X","authenticated-orcid":false,"given":"Montaser M. Y.","family":"Amro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4319-9032","authenticated-orcid":false,"given":"Aysegul","family":"Bostanci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3319-2179","authenticated-orcid":false,"given":"Buket","family":"Baddal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"12726_CR1","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/1471-2180-11-50","volume":"11","author":"YC Lin","year":"2011","unstructured":"Lin YC, Lu MC, Tang HL, Liu HC, Chen CH, Liu KS, Lin C, Chiou CS, Chiang MK, Chen CM, Lai YC (2011) Assessment of hypermucoviscosity as a virulence factor for experimental Klebsiella pneumoniae infections: comparative virulence analysis with hypermucoviscosity-negative strain. BMC Microbiol 11:50. https:\/\/doi.org\/10.1186\/1471-2180-11-50","journal-title":"BMC Microbiol"},{"key":"12726_CR2","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1128\/MMBR.00078-15","volume":"80","author":"MK Paczosa","year":"2016","unstructured":"Paczosa MK, Mecsas J (2016) Klebsiella pneumoniae: going on the offense with a strong defense. Microbiol Mol Biol Rev 80:629\u2013661. https:\/\/doi.org\/10.1128\/MMBR.00078-15","journal-title":"Microbiol Mol Biol Rev"},{"key":"12726_CR3","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1080\/21505594.2020.1809322","volume":"11","author":"C Liu","year":"2020","unstructured":"Liu C, Du P, Xiao N, Ji F, Russo TA, Guo J (2020) Hypervirulent Klebsiella pneumoniae is emerging as an increasingly prevalent K. pneumoniae pathotype responsible for nosocomial and healthcare-associated infections in Beijing, China. Virulence 11:1215\u20131224. https:\/\/doi.org\/10.1080\/21505594.2020.1809322","journal-title":"Virulence"},{"issue":"1","key":"12726_CR4","doi-asserted-by":"publisher","first-page":"80","DOI":"10.20411\/pai.v10i1.777","volume":"10","author":"D Al Ismail","year":"2025","unstructured":"Al Ismail D, Campos-Madueno EI, Don\u00e0 V, Endimiani A (2025) Hypervirulent Klebsiella pneumoniae (hvKp): overview, epidemiology, and laboratory detection. Pathog Immun 10(1):80\u2013119. https:\/\/doi.org\/10.20411\/pai.v10i1.777","journal-title":"Pathog Immun"},{"key":"12726_CR5","doi-asserted-by":"publisher","first-page":"E3574","DOI":"10.1073\/pnas.1501049112","volume":"112","author":"KE Holt","year":"2015","unstructured":"Holt KE, Wertheim H, Zadoks RN, Baker S, Whitehouse CA, Dance D, Jenney A, Connor TR, Hsu LY, Severin J, Brisse S, Cao H, Wilksch J, Gorrie C, Schultz MB, Edwards DJ, Nguyen KV, Nguyen TV, Dao TT, Thomson NR (2015) Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health. Proc Natl Acad Sci U S A 112:E3574\u2013E3581. https:\/\/doi.org\/10.1073\/pnas.1501049112","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12726_CR6","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.3201\/eid2011.140206","volume":"20","author":"S Bialek-Davenet","year":"2014","unstructured":"Bialek-Davenet S, Criscuolo A, Ailloud F, Passet V, Jones L, Delannoy-Vieillard AS, Garin B, Le Hello S, Arlet G, Nicolas-Chanoine MH, Decr\u00e9 D, Brisse S (2014) Genomic definition of hypervirulent and multidrug-resistant Klebsiella pneumoniae clonal groups. Emerg Infect Dis 20:1812\u20131820. https:\/\/doi.org\/10.3201\/eid2011.140206","journal-title":"Emerg Infect Dis"},{"key":"12726_CR7","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.jinf.2015.07.010","volume":"71","author":"Y Zhang","year":"2015","unstructured":"Zhang Y, Zeng J, Liu W, Zhao F, Hu Z, Zhao C, Wang Q, Wang X, Chen H, Li H, Zhang F, Li S, Cao B, Wang H (2015) Emergence of a hypervirulent carbapenem-resistant Klebsiella pneumoniae isolate from clinical infections in China. J Infect 71:553\u2013560. https:\/\/doi.org\/10.1016\/j.jinf.2015.07.010","journal-title":"J Infect"},{"key":"12726_CR8","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00776-18","volume":"56","author":"TA Russo","year":"2018","unstructured":"Russo TA, Olson R, Fang CT, Stoesser N, Miller M, MacDonald U, Hutson A, Barker JH, La Hoz RM, Johnson JR (2018) Identification of biomarkers for differentiation of hypervirulent Klebsiella pneumoniae from classical K. pneumoniae. J Clin Microbiol 56:e00776-18. https:\/\/doi.org\/10.1128\/JCM.00776-18","journal-title":"J Clin Microbiol"},{"key":"12726_CR9","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S1473-3099(17)30489-9","volume":"18","author":"D Gu","year":"2018","unstructured":"Gu D, Dong N, Zheng Z, Lin D, Huang M, Wang L, Chan EWC, Shu L, Yu J, Zhang R, Chen S (2018) A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study. Lancet Infect Dis 18:37\u201346. https:\/\/doi.org\/10.1016\/S1473-3099(17)30489-9","journal-title":"Lancet Infect Dis"},{"key":"12726_CR10","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1128\/AAC.02173-15","volume":"60","author":"R Zhang","year":"2016","unstructured":"Zhang R, Lin D, Chan EWC, Gu D, Chen GX, Chen S (2016) Emergence of carbapenem-resistant serotype K1 hypervirulent Klebsiella pneumoniae strains in China. Antimicrob Agents Chemother 60:709\u2013711. https:\/\/doi.org\/10.1128\/AAC.02173-15","journal-title":"Antimicrob Agents Chemother"},{"key":"12726_CR11","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s00284-025-04311-0","volume":"82","author":"MK Thirugnanasambantham","year":"2025","unstructured":"Thirugnanasambantham MK, Thuthikkadu Indhuprakash S, Thirumalai D (2025) Phenotypic and genotypic characteristics of hypervirulent Klebsiella pneumoniae (hvKp): a narrative review. Curr Microbiol 82:341. https:\/\/doi.org\/10.1007\/s00284-025-04311-0","journal-title":"Curr Microbiol"},{"key":"12726_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.709681","volume":"11","author":"C Shankar","year":"2021","unstructured":"Shankar C, Basu S, Lal B, Shanmugam S, Vasudevan K, Mathur P, Ramaiah S, Anbarasu A, Veeraraghavan B (2021) Aerobactin seems to be a promising marker compared with unstable RmpA2 for the identification of hypervirulent carbapenem-resistant Klebsiella pneumoniae: in silico and in vitro evidence. Front Cell Infect Microbiol 11:709681. https:\/\/doi.org\/10.3389\/fcimb.2021.709681","journal-title":"Front Cell Infect Microbiol"},{"key":"12726_CR13","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1080\/22221751.2022.2049458","volume":"11","author":"X Yang","year":"2022","unstructured":"Yang X, Sun Q, Li J, Jiang Y, Li Y, Lin J, Chen K, Chan EWC, Zhang R, Chen S (2022) Molecular epidemiology of carbapenem-resistant hypervirulent Klebsiella pneumoniae in China. Emerg Microbes Infect 11:841\u2013849. https:\/\/doi.org\/10.1080\/22221751.2022.2049458","journal-title":"Emerg Microbes Infect"},{"issue":"1","key":"12726_CR14","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/s13756-023-01331-y","volume":"12","author":"L Li","year":"2023","unstructured":"Li L, Li S, Wei X, Lu Z, Qin X, Li M (2023) Infection with carbapenem-resistant hypervirulent Klebsiella pneumoniae: clinical, virulence and molecular epidemiological characteristics. Antimicrob Resist Infect Control 12(1):124. https:\/\/doi.org\/10.1186\/s13756-023-01331-y","journal-title":"Antimicrob Resist Infect Control"},{"key":"12726_CR15","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.jgar.2021.02.020","volume":"25","author":"P Lan","year":"2021","unstructured":"Lan P, Jiang Y, Zhou J, Yu Y (2021) A global perspective on the convergence of hypervirulence and carbapenem resistance in Klebsiella pneumoniae. J Glob Antimicrob Resist 25:26\u201334. https:\/\/doi.org\/10.1016\/j.jgar.2021.02.020","journal-title":"J Glob Antimicrob Resist"},{"issue":"7","key":"12726_CR16","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.12669\/pjms.42.7.13601","volume":"42","author":"L Xu","year":"2026","unstructured":"Xu L, Chen L, Sun Y, An Y (2026) Molecular epidemiological analysis of carbapenem-resistant hypervirulent Klebsiella pneumoniae in Cangzhou Central Hospital from 2021 to 2024. Pak J Med Sci 42(7):1819\u20131824. https:\/\/doi.org\/10.12669\/pjms.42.7.13601","journal-title":"Pak J Med Sci"},{"issue":"4","key":"12726_CR17","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1093\/labmed\/lmae110","volume":"56","author":"Q Wang","year":"2025","unstructured":"Wang Q, Ye M-Y, Hong C, Li Z-P, Lin L (2025) The mechanisms of resistance, epidemiological characteristics, and molecular evolution of carbapenem-resistant hypervirulent Klebsiella pneumoniae. Lab Med 56(4):323\u2013335. https:\/\/doi.org\/10.1093\/labmed\/lmae110","journal-title":"Lab Med"},{"key":"12726_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2025.1680292","volume":"13","author":"J Chen","year":"2025","unstructured":"Chen J, Hou Y, Shi J, Gao X, Liang G (2025) Mortality risk of carbapenem-resistant hypervirulent Klebsiella pneumoniae vs. classical CR-KP: a systematic review and meta-analysis. Front Public Health 13:1680292. https:\/\/doi.org\/10.3389\/fpubh.2025.1680292","journal-title":"Front Public Health"},{"key":"12726_CR19","unstructured":"CLSI (2022) Performance standards for antimicrobial susceptibility testing. 32nd ed. CLSI supplement M100. Clinical and Laboratory Standards Institute"},{"key":"12726_CR20","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1046\/j.1469-0691.2001.00204.x","volume":"7","author":"K Lee","year":"2001","unstructured":"Lee K, Chong Y, Shin HB, Kim YA, Yong D, Yum JH (2001) Modified Hodge and EDTA-disk synergy tests to screen metallo-\u03b2-lactamase-producing strains of Pseudomonas and Acinetobacter species. Clin Microbiol Infect 7:88\u201391. https:\/\/doi.org\/10.1046\/j.1469-0691.2001.00204.x","journal-title":"Clin Microbiol Infect"},{"key":"12726_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-416999-9.00007-1","author":"C Barbosa","year":"2016","unstructured":"Barbosa C, Nogueira S, Gadanho M, Chaves S (2016) DNA extraction: Finding the most suitable method. Molecular Microbial Diagnostic Methods. https:\/\/doi.org\/10.1016\/B978-0-12-416999-9.00007-1","journal-title":"Molecular Microbial Diagnostic Methods"},{"key":"12726_CR22","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.diagmicrobio.2010.12.002","volume":"70","author":"L Poirel","year":"2011","unstructured":"Poirel L, Walsh TR, Cuvillier V, Nordmann P (2011) Multiplex PCR for detection of acquired carbapenemase genes. Diagn Microbiol Infect Dis 70:119\u2013123. https:\/\/doi.org\/10.1016\/j.diagmicrobio.2010.12.002","journal-title":"Diagn Microbiol Infect Dis"},{"key":"12726_CR23","unstructured":"European Centre for Disease Prevention and Control (2023) Antimicrobial resistance in the EU\/EEA (EARS-Net)\u2014Annual Epidemiological Report for 2023. Available online: https:\/\/www.ecdc.europa.eu\/en\/publications-data\/antimicrobial-resistance-eueea-ears-net-annual-epidemiological-report-2023 (accessed 14 April 2026)"},{"key":"12726_CR24","unstructured":"European Centre for Disease Prevention and Control (2025) Carbapenem-resistant Enterobacterales, third update\u20143 February 2025. Available online: https:\/\/www.ecdc.europa.eu\/en\/publications-data\/carbapenem-resistant-enterobacterales-rapid-risk-assessment-third-update (accessed 14 April 2026)"},{"key":"12726_CR25","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/s12866-026-04727-z","volume":"26","author":"S Mermer","year":"2026","unstructured":"Mermer S, \u00c7a\u011flayan E (2026) Prevalence, clinical characteristics, and antibiotic resistance of carbapenem-resistant Klebsiella pneumoniae in a tertiary hospital in T\u00fcrkiye (2023\u20132025). BMC Microbiol 26:114. https:\/\/doi.org\/10.1186\/s12866-026-04727-z","journal-title":"BMC Microbiol"},{"key":"12726_CR26","unstructured":"European Centre for Disease Prevention and Control. Surveillance atlas of infectious diseases. Available online: https:\/\/www.ecdc.europa.eu\/en\/surveillance-atlas-infectious-diseases (accessed 14 April 2026)"},{"key":"12726_CR27","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.jgar.2022.05.012","volume":"30","author":"Y Li","year":"2022","unstructured":"Li Y et al (2022) Global prevalence and molecular characteristics of carbapenem-resistant hypervirulent Klebsiella pneumoniae: a systematic review and meta-analysis. J Glob Antimicrob Resist 30:96\u2013104. https:\/\/doi.org\/10.1016\/j.jgar.2022.05.012","journal-title":"J Glob Antimicrob Resist"},{"key":"12726_CR28","doi-asserted-by":"publisher","first-page":"203","DOI":"10.2147\/IDR.S345123","volume":"15","author":"D Tian","year":"2022","unstructured":"Tian D et al (2022) Prevalence of carbapenem-resistant hypervirulent Klebsiella pneumoniae and molecular characteristics. Infect Drug Resist 15:203\u2013213. https:\/\/doi.org\/10.2147\/IDR.S345123","journal-title":"Infect Drug Resist"},{"key":"12726_CR29","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.ijid.2018.05.008","volume":"73","author":"B Isler","year":"2018","unstructured":"Isler B et al (2018) Carbapenem-resistant Klebsiella pneumoniae infections in Turkey: clinical and molecular characteristics. Int J Infect Dis 73:38\u201343. https:\/\/doi.org\/10.1016\/j.ijid.2018.05.008","journal-title":"Int J Infect Dis"},{"key":"12726_CR30","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1038\/s41564-019-0492-8","volume":"4","author":"S David","year":"2019","unstructured":"David S, Reuter S, Harris SR, Glasner C, Feltwell T, Argim\u00f3n S et al (2019) Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread. Nat Microbiol 4:1919\u20131929. https:\/\/doi.org\/10.1038\/s41564-019-0492-8","journal-title":"Nat Microbiol"},{"key":"12726_CR31","unstructured":"World Health Organization (2024) Antimicrobial resistance, hypervirulent Klebsiella pneumoniae\u2014Global situation. Available online: https:\/\/www.who.int\/emergencies\/disease-outbreak-news\/item\/2024-DON527 (accessed 12 April 2026)"},{"key":"12726_CR32","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.25.20.2000627","volume":"25","author":"C Ludden","year":"2020","unstructured":"Ludden C, L\u00f6tsch F, Alm E, Kumar N, Johansson K, Albiger B et al (2020) Cross-border spread of bla(NDM-1)- and bla(OXA-48)-positive Klebsiella pneumoniae: a European collaborative analysis of whole genome sequencing and epidemiological data, 2014 to 2019. Euro Surveill 25:2000627. https:\/\/doi.org\/10.2807\/1560-7917.ES.2020.25.20.2000627","journal-title":"Euro Surveill"},{"key":"12726_CR33","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s40121-024-01097-9","volume":"14","author":"M Biedrzycka","year":"2025","unstructured":"Biedrzycka M, Izdebski R, Hryniewicz W, Gniadkowski M, \u017babicka D (2025) Carbapenemase-producing Enterobacterales from patients arriving from Ukraine in Poland, March 2022\u2013February 2023. Infect Dis Ther 14:401\u2013419. https:\/\/doi.org\/10.1007\/s40121-024-01097-9","journal-title":"Infect Dis Ther"},{"key":"12726_CR34","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2023.28.1.2200850","volume":"28","author":"T Schultze","year":"2023","unstructured":"Schultze T, Hogardt M, Vel\u00e1zquez ES, Hack D, Besier S, Wichelhaus TA, Rochwalsky U, Kempf VAJ, Reinheimer C (2023) Molecular surveillance of multidrug-resistant Gram-negative bacteria in Ukrainian patients, Germany, March to June 2022. Euro Surveill 28:2200850. https:\/\/doi.org\/10.2807\/1560-7917.ES.2023.28.1.2200850","journal-title":"Euro Surveill"},{"key":"12726_CR35","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2022.27.50.2200896","volume":"27","author":"RD Zwittink","year":"2022","unstructured":"Zwittink RD, Wielders CCH, Notermans DW, Verkaik NJ, Schoffelen AF, Witteveen S et al (2022) Multidrug-resistant organisms in patients from Ukraine in the Netherlands, March to August 2022. Euro Surveill 27:2200896. https:\/\/doi.org\/10.2807\/1560-7917.ES.2022.27.50.2200896","journal-title":"Euro Surveill"},{"key":"12726_CR36","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3389\/fmicb.2017.00133","volume":"8","author":"L Xie","year":"2017","unstructured":"Xie L, Dou Y, Zhou K, Chen Y, Han L, Guo X, Sun J (2017) Coexistence of blaOXA-48 and truncated blaNDM-1 on different plasmids in a Klebsiella pneumoniae isolate in China. Front Microbiol 8:133. https:\/\/doi.org\/10.3389\/fmicb.2017.00133","journal-title":"Front Microbiol"},{"key":"12726_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2026.106222","volume":"126","author":"X Li","year":"2026","unstructured":"Li X, Han X, Tang X, Fan Z, Ding L, Geng R, Chen Q, Huang J, Yao J, Zhou L, Du X, Liu J, Xie Y, Sun S, Yu H, Ma R, He J, Fu Y, Zhou H, Yu Y (2026) Clinical characteristics and molecular epidemiology of KPC-NDM co-producing carbapenem-resistant Klebsiella pneumoniae in China: a multicentre retrospective case-control study. EBioMedicine 126:106222. https:\/\/doi.org\/10.1016\/j.ebiom.2026.106222","journal-title":"EBioMedicine"},{"key":"12726_CR38","doi-asserted-by":"publisher","first-page":"459","DOI":"10.3390\/microorganisms11020459","volume":"11","author":"ES Kuzina","year":"2023","unstructured":"Kuzina ES, Kislichkina AA, Sizova AA, Skryabin YP, Novikova TS, Ershova ON, Savin IA, Khokhlova OE, Bogun AG, Fursova NK (2023) High-molecular-weight plasmids carrying carbapenemase genes blaNDM-1, blaKPC-2, and blaOXA-48 coexisting in clinical Klebsiella pneumoniae strains of ST39. Microorganisms 11:459. https:\/\/doi.org\/10.3390\/microorganisms11020459","journal-title":"Microorganisms"},{"key":"12726_CR39","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.2147\/IDR.S245104","volume":"13","author":"N Alizadeh","year":"2020","unstructured":"Alizadeh N et al (2020) Molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae in the Middle East region. Infect Drug Resist 13:1077\u20131085. https:\/\/doi.org\/10.2147\/IDR.S245104","journal-title":"Infect Drug Resist"},{"key":"12726_CR40","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02474-25","volume":"14","author":"TTT Duong","year":"2026","unstructured":"Duong TTT, Lin WH, Tsai YM, Liao CH, Huang YT, Hsueh PR, Kao CY (2026) A combined genetic and phenotypic marker approach enables precise detection of hypervirulent Klebsiella pneumoniae and reveals associated traits of capsule overproduction and tellurite resistance. Microbiol Spectr 14:e02474-25. https:\/\/doi.org\/10.1128\/spectrum.02474-25","journal-title":"Microbiol Spectr"},{"key":"12726_CR41","doi-asserted-by":"publisher","DOI":"10.1186\/s12941-018-0302-9","volume":"18","author":"C Liu","year":"2019","unstructured":"Liu C, Guo J (2019) Hypervirulent Klebsiella pneumoniae (hypermucoviscous and aerobactin positive) infection over 6 years in the elderly in China: antimicrobial resistance patterns, molecular epidemiology and risk factor. Ann Clin Microbiol Antimicrob 18:4. https:\/\/doi.org\/10.1186\/s12941-018-0302-9","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"12726_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-46221-w","volume":"13","author":"B Neumann","year":"2023","unstructured":"Neumann B, St\u00fcrhof C, Rath A, Kieninger B, Eger E, M\u00fcller JU, von Poblocki A, Gerlitz N, Wollschl\u00e4ger P, Schneider-Brachert W, Schaufler K, Klaper K, Steinmann J (2023) Detection and characterization of putative hypervirulent Klebsiella pneumoniae isolates in microbiological diagnostics. Sci Rep 13:19025. https:\/\/doi.org\/10.1038\/s41598-023-46221-w","journal-title":"Sci Rep"},{"key":"12726_CR43","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1556\/030.2020.01143","volume":"67","author":"S \u00d6rsten","year":"2020","unstructured":"\u00d6rsten S, Demirci-Duarte S, \u00dcnalan-Alt\u0131ntop T, \u00c7akar A, Sancak B, Erg\u00fcnay K, \u00d6zkuyumcu C (2020) Low prevalence of hypervirulent Klebsiella pneumoniae in Anatolia, screened via phenotypic and genotypic testing. Acta Microbiol Immunol Hung 67:120\u2013126. https:\/\/doi.org\/10.1556\/030.2020.01143","journal-title":"Acta Microbiol Immunol Hung"},{"key":"12726_CR44","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1003783","volume":"13","author":"YL Han","year":"2022","unstructured":"Han YL, Wen XH, Zhao W, Cao XS, Wen JX, Wang JR, Hu ZD, Zheng WQ (2022) Epidemiological characteristics and molecular evolution mechanisms of carbapenem-resistant hypervirulent Klebsiella pneumoniae. Front Microbiol 13:1003783. https:\/\/doi.org\/10.3389\/fmicb.2022.1003783","journal-title":"Front Microbiol"},{"key":"12726_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlife.2024.06.005","author":"T Chen","year":"2024","unstructured":"Chen T, Ying L, Xiong L, Wang X, Lu P, Wang Y, Shen P, Xiao Y (2024) Understanding carbapenem-resistant hypervirulent Klebsiella pneumoniae: key virulence factors and evolutionary convergence. Hum Life Sci. https:\/\/doi.org\/10.1016\/j.hlife.2024.06.005","journal-title":"Hum Life Sci"},{"key":"12726_CR46","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.2147\/IDR.S405816","volume":"16","author":"B Yadav","year":"2023","unstructured":"Yadav B, Mohanty S, Behera B (2023) Occurrence and genomic characteristics of hypervirulent Klebsiella pneumoniae in a tertiary care hospital, Eastern India. Infect Drug Resist 16:2191\u20132201. https:\/\/doi.org\/10.2147\/IDR.S405816","journal-title":"Infect Drug Resist"},{"key":"12726_CR47","doi-asserted-by":"publisher","first-page":"3647","DOI":"10.2147\/IDR.S529532","volume":"18","author":"M Qiu","year":"2025","unstructured":"Qiu M, Tian S, Dou L, Wang J, Xu L, Wu M, Zhou Z, Li J, Wu W, Ren J, Wu X (2025) Clinical characterization, risk factors, and mortality in patients with carbapenem-resistant hypervirulent Klebsiella pneumoniae intra-abdominal infections. Infect Drug Resist 18:3647\u20133660. https:\/\/doi.org\/10.2147\/IDR.S529532","journal-title":"Infect Drug Resist"},{"issue":"5","key":"12726_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanmic.2025.101090","volume":"6","author":"Y Yang","year":"2025","unstructured":"Yang Y, McNally A, Zong Z (2025) Call for prudent use of the term hypervirulence in carbapenem-resistant Klebsiella pneumoniae. Lancet Microbe 6(5):101090. https:\/\/doi.org\/10.1016\/j.lanmic.2025.101090","journal-title":"Lancet Microbe"},{"issue":"3","key":"12726_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.imj.2026.100272","volume":"5","author":"SM Kulkarni","year":"2026","unstructured":"Kulkarni SM, Jacob JJ, Manesh A, Veeraraghavan B (2026) Emerging hypervirulent Klebsiella pneumoniae: myth, reality, and clinical relevance. Infect Med (Beijing) 5(3):100272. https:\/\/doi.org\/10.1016\/j.imj.2026.100272","journal-title":"Infect Med (Beijing)"},{"issue":"2","key":"12726_CR50","doi-asserted-by":"publisher","first-page":"127","DOI":"10.32607\/actanaturae.27800","volume":"18","author":"AV Tutel\u2019yan","year":"2026","unstructured":"Tutel\u2019yan AV, Vlasenko NV, Pisarev VM, Mikhailova YV, Sycheva NV, Tarlycheva AA, Shelenkov AA, Kondrat\u2019eva DK, Akimkin VG (2026) The potential role of the bacterial persister formation gene ptsH in hypervirulence development in Klebsiella pneumoniae. Acta Naturae. 18(2):127\u2013134","journal-title":"Acta Naturae."},{"key":"12726_CR51","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2026.1885799","volume":"17","author":"TK Sahu","year":"2026","unstructured":"Sahu TK, Gadkari P, Rathored J (2026) Carbapenem-resistant hypervirulent Klebsiella pneumoniae: molecular evolution, diagnostic markers, and therapeutic challenges. Front Microbiol 17:1885799. https:\/\/doi.org\/10.3389\/fmicb.2026.1885799","journal-title":"Front Microbiol"},{"key":"12726_CR52","unstructured":"European Centre for Disease Prevention and Control (2025) Rapid risk assessment\u2014Emergence of hypervirulent Klebsiella pneumoniae ST23 carrying carbapenemase genes in EU\/EEA countries\u2014first update. Available online: https:\/\/www.ecdc.europa.eu\/en\/publications-data\/risk-assessment-emergence-hypervirulent-klebsiella-pneumoniae-eu-eea (accessed 12 April 2026)"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12726-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12726-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12726-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:21:26Z","timestamp":1788870086000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12726-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12726"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12726-6","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,8]]},"assertion":[{"value":"9 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Near East University (2022\/109\u20131666, 29 December 2022).","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1555"}}