{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:15:18Z","timestamp":1789168518469,"version":"build-2803163510"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12751-5","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:57:20Z","timestamp":1789124240000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Natural products targeting the molecular pathology of salivary gland mucoepidermoid carcinoma: A systematic review of In vitro studies"],"prefix":"10.1007","volume":"53","author":[{"given":"Stella","family":"Marleen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Upik Anderiani","family":"Miskad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Husni","family":"Cangara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prihantono","family":"Prihantono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosi Yohanes","family":"Putra Tandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurlinah","family":"Amalia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adha Fauzi","family":"Hendrawan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2151-0854","authenticated-orcid":false,"given":"Fahrul","family":"Nurkolis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"issue":"4","key":"12751_CR1","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1093\/jjco\/hyac008","volume":"52","author":"Y Imamura","year":"2022","unstructured":"Imamura Y, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Homma A (2022) Systemic therapy for salivary gland malignancy: current status and future perspectives. Jpn J Clin Oncol 52(4):293\u2013302","journal-title":"Jpn J Clin Oncol"},{"issue":"15","key":"12751_CR2","doi-asserted-by":"publisher","first-page":"3585","DOI":"10.3390\/cancers14153585","volume":"14","author":"BF Tan","year":"2022","unstructured":"Tan BF, Tan WCC, Wang FQ, Lechner M, Schartinger VH, Tan DSW, Nei WL (2022) PSMA PET imaging and therapy in adenoid cystic carcinoma and other salivary gland cancers: A systematic review. Cancers 14(15):3585","journal-title":"Cancers"},{"issue":"102697","key":"12751_CR3","doi-asserted-by":"publisher","first-page":"102697","DOI":"10.1016\/j.ctrv.2024.102697","volume":"124","author":"L Rached","year":"2024","unstructured":"Rached L, Saleh K, Casiraghi O, Even C (2024) Salivary gland carcinoma: Towards a more personalised approach. Cancer Treat Rev 124(102697):102697","journal-title":"Cancer Treat Rev"},{"key":"12751_CR4","doi-asserted-by":"publisher","first-page":"1032471","DOI":"10.3389\/fonc.2022.1032471","volume":"12","author":"E Colombo","year":"2022","unstructured":"Colombo E, Van Lierde C, Zlate A, Jensen A, Gatta G, Didon\u00e8 F, Locati LD (2022) Salivary gland cancers in elderly patients: challenges and therapeutic strategies. Front Oncol 12:1032471","journal-title":"Front Oncol"},{"issue":"6","key":"12751_CR5","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.jormas.2020.06.003","volume":"121","author":"A Peraza","year":"2020","unstructured":"Peraza A, G\u00f3mez R, Beltran J, Amarista FJ (2020) Mucoepidermoid carcinoma. An update and review of the literature. J Stomatology Oral Maxillofacial Surg 121(6):713\u2013720","journal-title":"J Stomatology Oral Maxillofacial Surg"},{"issue":"6","key":"12751_CR6","doi-asserted-by":"publisher","first-page":"597","DOI":"10.3322\/caac.21807","volume":"73","author":"CE Steuer","year":"2023","unstructured":"Steuer CE, Hanna GJ, Viswanathan K, Bates JE, Kaka AS, Schmitt NC, Saba NF (2023) The evolving landscape of salivary gland tumors. Cancer J Clin 73(6):597\u2013619","journal-title":"Cancer J Clin"},{"key":"12751_CR7","doi-asserted-by":"publisher","first-page":"1373821","DOI":"10.3389\/fonc.2024.1373821","volume":"14","author":"M Constantin","year":"2024","unstructured":"Constantin M, Chifiriuc MC, Bleotu C, Vrancianu CO, Cristian R-E, Bertesteanu SV, Bertesteanu G (2024) Molecular pathways and targeted therapies in head and neck cancers pathogenesis. Front Oncol 14:1373821","journal-title":"Front Oncol"},{"issue":"12","key":"12751_CR8","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1002\/cncr.29890","volume":"122","author":"LX Yin","year":"2016","unstructured":"Yin LX, Ha PK (2016) Genetic alterations in salivary gland cancers. Cancer 122(12):1822\u20131831","journal-title":"Cancer"},{"issue":"4","key":"12751_CR9","doi-asserted-by":"publisher","first-page":"660","DOI":"10.3390\/cancers17040660","volume":"17","author":"E Broseghini","year":"2025","unstructured":"Broseghini E, Carosi F, Berti M, Compagno S, Ghelardini A, Fermi M, Filippini DM (2025) Salivary gland cancers in the era of molecular analysis: The role of tissue and liquid biomarkers. Cancers 17(4):660","journal-title":"Cancers"},{"key":"12751_CR10","doi-asserted-by":"publisher","first-page":"580141","DOI":"10.3389\/fonc.2020.580141","volume":"10","author":"L Di Villeneuve","year":"2020","unstructured":"Di Villeneuve L, Souza IL, Tolentino FDS, Ferrarotto R, Schvartsman G (2020) Salivary gland carcinoma: Novel targets to overcome treatment resistance in advanced disease. Front Oncol 10:580141","journal-title":"Front Oncol"},{"issue":"4","key":"12751_CR11","doi-asserted-by":"publisher","first-page":"232","DOI":"10.3390\/curroncol32040232","volume":"32","author":"S Sreenivasan","year":"2025","unstructured":"Sreenivasan S, Jiwani RA, White R, Bakalov V, Moll R, Liput J, Greenberg L (2025) Advances in targeted and systemic therapy for salivary gland carcinomas: Current options and future directions. Curr Oncol (Toronto Ont) 32(4):232","journal-title":"Curr Oncol (Toronto Ont)"},{"issue":"10","key":"12751_CR12","doi-asserted-by":"publisher","first-page":"e71390","DOI":"10.1002\/hsr2.71390","volume":"8","author":"M Mohiuddin","year":"2025","unstructured":"Mohiuddin M (2025) Targeting MCL-1 to overcome therapeutic resistance and improve cancer mortality. Health Sci Rep 8(10):e71390","journal-title":"Health Sci Rep"},{"issue":"5","key":"12751_CR13","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1002\/hed.27307","volume":"45","author":"AN Weaver","year":"2023","unstructured":"Weaver AN, Lakritz S, Mandair D, Ulanja MB, Bowles DW (2023) A molecular guide to systemic therapy in salivary gland carcinoma. Head Neck 45(5):1315\u20131326","journal-title":"Head Neck"},{"issue":"23","key":"12751_CR14","doi-asserted-by":"publisher","first-page":"8367","DOI":"10.3390\/molecules27238367","volume":"27","author":"A Naeem","year":"2022","unstructured":"Naeem A, Hu P, Yang M, Zhang J, Liu Y, Zhu W, Zheng Q (2022) Natural products as anticancer agents: Current status and future perspectives. Molecules 27(23):8367","journal-title":"Molecules"},{"issue":"1","key":"12751_CR15","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s13659-025-00511-0","volume":"15","author":"P Quintero-Rinc\u00f3n","year":"2025","unstructured":"Quintero-Rinc\u00f3n P, Caballero-Gallardo K, Olivero-Verbel J (2025) Natural anticancer agents: prospection of medicinal and aromatic plants in modern chemoprevention and chemotherapy. Nat Prod Bioprospecting 15(1):25","journal-title":"Nat Prod Bioprospecting"},{"issue":"24","key":"12751_CR16","doi-asserted-by":"publisher","first-page":"6203","DOI":"10.3390\/cancers14246203","volume":"14","author":"ST Asma","year":"2022","unstructured":"Asma ST, Acaroz U, Imre K, Morar A, Shah SRA, Hussain SZ, Ince S (2022) Natural products\/bioactive compounds as a source of anticancer drugs. Cancers 14(24):6203","journal-title":"Cancers"},{"key":"12751_CR17","doi-asserted-by":"publisher","first-page":"950109","DOI":"10.3389\/fphar.2022.950109","volume":"13","author":"MM Rahman","year":"2022","unstructured":"Rahman MM, Sarker MT, Tumpa A, Yamin MA, Islam M, Park T, Kim MN, B (2022) Exploring the recent trends in perturbing the cellular signaling pathways in cancer by natural products. Front Pharmacol 13:950109","journal-title":"Front Pharmacol"},{"issue":"4","key":"12751_CR18","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1002\/ptr.7755","volume":"37","author":"AU Khan","year":"2023","unstructured":"Khan AU, Khan A, Shal B, Khan S, Khan M, Ahmad R, Riaz M (2023) The critical role of the phytosterols in modulating tumor microenvironment via multiple signaling: A comprehensive molecular approach. Phytother Res 37(4):1606\u20131623","journal-title":"Phytother Res"},{"issue":"3","key":"12751_CR19","first-page":"355","volume":"46","author":"EA Alazazi","year":"2024","unstructured":"Alazazi EA, Roslan A, Aziz FMA, Vanoh D, Seeni A, Ahmed S, Murtey MD (2024) Chemoprevention of natural product against oral cancer: A comprehensive review. Malays J Pathol 46(3):355\u2013368","journal-title":"Malays J Pathol"},{"issue":"4","key":"12751_CR20","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1002\/ptr.7738","volume":"37","author":"Y Yang","year":"2023","unstructured":"Yang Y, Chen Y, Wu JH, Ren Y, Liu B, Zhang Y, Yu H (2023) Targeting regulated cell death with plant natural compounds for cancer therapy: A revisited review of apoptosis, autophagy-dependent cell death, and necroptosis. Phytother Res 37(4):1488\u20131525","journal-title":"Phytother Res"},{"key":"12751_CR21","doi-asserted-by":"publisher","first-page":"S165","DOI":"10.1016\/j.toxlet.2025.07.403","volume":"411","author":"S-I Dumitrel","year":"2025","unstructured":"Dumitrel S-I, Smeu A, Cristea A, Dehelean CA (2025) P14-25 targeting salivary gland carcinoma: Quercetin as a promising natural therapeutic candidate with anticancer and antioxidant potential in A-253 cells. Toxicol Lett 411:S165","journal-title":"Toxicol Lett"},{"key":"12751_CR22","first-page":"n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Moher D (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ (Clinical Res Ed) 372:n71","journal-title":"BMJ (Clinical Res Ed)"},{"issue":"6","key":"12751_CR23","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1016\/j.prosdent.2022.05.019","volume":"131","author":"VH Sheth","year":"2024","unstructured":"Sheth VH, Shah NP, Jain R, Bhanushali N, Bhatnagar V (2024) Development and validation of a risk-of-bias tool for assessing in vitro studies conducted in dentistry: The QUIN. J Prosthet Dent 131(6):1038\u20131042","journal-title":"J Prosthet Dent"},{"key":"12751_CR24","doi-asserted-by":"publisher","first-page":"746430","DOI":"10.3389\/ftox.2021.746430","volume":"3","author":"N Roth","year":"2021","unstructured":"Roth N, Zilliacus J, Beronius A (2021) Development of the SciRAP approach for evaluating the reliability and relevance of in vitro toxicity data. Front Toxicol 3:746430","journal-title":"Front Toxicol"},{"issue":"4","key":"12751_CR25","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1007\/s10637-010-9402-x","volume":"29","author":"XF Xu","year":"2011","unstructured":"Xu XF, Cai BL, Guan SM, Li Y, Wu JZ, Wang Y, Liu B (2011) Baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and in vivo. Investig New Drugs 29(4):637\u2013645","journal-title":"Investig New Drugs"},{"issue":"Fig 1","key":"12751_CR26","first-page":"1","volume":"13","author":"XF Xu","year":"2013","unstructured":"Xu XF, Zhang TL, Jin S, Wang R, Xiao X, Zhang WD, Wang XJ (2013) Ardipusilloside I induces apoptosis by regulating Bcl-2 family proteins in human mucoepidermoid carcinoma Mc3 cells. BMC Complement Altern Med 13(Fig 1):1\u20139","journal-title":"BMC Complement Altern Med"},{"issue":"4","key":"12751_CR27","doi-asserted-by":"publisher","first-page":"939","DOI":"10.3892\/ijmm.2016.2517","volume":"37","author":"HN Lee","year":"2016","unstructured":"Lee HN, Jang HY, Kim HJ, Shin SA, Choo GS, Park YS, Jung JY (2016) Antitumor and apoptosis-inducing effects of \u03b1-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.) in YD-15 tongue mucoepidermoid carcinoma cells. Int J Mol Med 37(4):939\u2013948","journal-title":"Int J Mol Med"},{"issue":"3","key":"12751_CR28","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s13402-017-0318-8","volume":"40","author":"ES Choi","year":"2017","unstructured":"Choi ES, Oh S, Jang B, Yu HJ, Shin JA, Cho NP, Cho SD (2017) Silymarin and its active component silibinin act as novel therapeutic alternatives for salivary gland cancer by targeting the ERK1\/2-Bim signaling cascade. Cell Oncol 40(3):235\u2013246","journal-title":"Cell Oncol"},{"issue":"1","key":"12751_CR29","doi-asserted-by":"publisher","first-page":"228","DOI":"10.3892\/etm.2013.1368","volume":"7","author":"HE Lee","year":"2013","unstructured":"Lee HE, Choi ES, Shin JA, Lee SO, Park KS, Cho NP, Cho SD (2013) Fucoidan induces caspase-dependent apoptosis in MC3 human mucoepidermoid carcinoma cells. Experimental Therapeutic Med 7(1):228\u2013232","journal-title":"Experimental Therapeutic Med"},{"key":"12751_CR30","doi-asserted-by":"publisher","unstructured":"Lee H, Nam J, Shin J, Hong I, Yang I, You M, Cho S (2016) Convallaria keiskei as a novel therapeutic alternative for salivary gland cancer treatment by targeting myeloid cell leukemia-1. Head Neck 38(S1). https:\/\/doi.org\/10.1002\/hed.24096","DOI":"10.1002\/hed.24096"},{"issue":"2","key":"12751_CR31","doi-asserted-by":"publisher","first-page":"663","DOI":"10.3892\/mmr.2013.1826","volume":"9","author":"H Ju Yu","year":"2014","unstructured":"Ju Yu H, Shin A, Lee J, Han Kwon SO, K., Cho SD (2014) Extracellular signal-regulated kinase inhibition is required for methanol extract of Smilax china L.-induced apoptosis through death receptor 5 in human oral mucoepidermoid carcinoma cells. Mol Med Rep 9(2):663\u2013668","journal-title":"Mol Med Rep"},{"issue":"1","key":"12751_CR32","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s43188-023-00206-z","volume":"40","author":"SJ Jeon","year":"2024","unstructured":"Jeon SJ, Jung GH, Choi EY, Han EJ, Lee JH, Han SH, Jung JY (2024) Kaempferol induces apoptosis through the MAPK pathway and regulates JNK-mediated autophagy in MC-3 cells. Toxicol Res 40(1):45\u201355","journal-title":"Toxicol Res"},{"key":"12751_CR33","doi-asserted-by":"publisher","unstructured":"Jung GH, Lee JH, Han SH, Woo JS, Choi EY, Jeon SJ, Jung JY (2022) Chrysin Induces Apoptosis via the MAPK Pathway and Regulates ERK\/mTOR-Mediated Autophagy in MC-3 Cells. Int J Mol Sci 23(24). https:\/\/doi.org\/10.3390\/ijms232415747","DOI":"10.3390\/ijms232415747"},{"issue":"1","key":"12751_CR34","doi-asserted-by":"publisher","first-page":"385","DOI":"10.3892\/ijo.2020.5061","volume":"57","author":"JM Han","year":"2020","unstructured":"Han JM, Hong KO, Yang IH, Ahn CH, Jin B, Lee W, Hong SD (2020) Oridonin induces the apoptosis of mucoepidermoid carcinoma cell lines in a myeloid cell leukemia\u20131\u2013dependent manner. Int J Oncol 57(1):385\u20132020","journal-title":"Int J Oncol"},{"issue":"1","key":"12751_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12935-021-02134-0","volume":"21","author":"SJ Choi","year":"2021","unstructured":"Choi SJ, Ahn CH, Hong KO, Kim JH, Hong SD, Shin JA, Cho SD (2021) Molecular mechanism underlying the apoptotic modulation by ethanol extract of Pseudolarix kaempferi in mucoepidermoid carcinoma of the salivary glands. Cancer Cell Int 21(1):1\u201312","journal-title":"Cancer Cell Int"},{"issue":"11","key":"12751_CR36","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1007\/s00109-020-01977-w","volume":"98","author":"HJ Kwon","year":"2020","unstructured":"Kwon HJ, Yoon K, Jung JY, Ryu MH, Kim SH, Yoo ES, Cho SD (2020) Targeting X chromosome-linked inhibitor of apoptosis protein in mucoepidermoid carcinoma of the head and neck: A novel therapeutic strategy using nitidine chloride. J Mol Med 98(11):1591\u20131602","journal-title":"J Mol Med"},{"issue":"39","key":"12751_CR37","doi-asserted-by":"publisher","first-page":"622","DOI":"10.4103\/0973-1296.139802","volume":"10","author":"S-D Cho","year":"2014","unstructured":"Cho S-D, Yu H-J, Park C, Kim S-J, Cho N-P (2014) Signal transducer and activators of transcription 3 regulates cryptotanshinone-induced apoptosis in human mucoepidermoid carcinoma cells. Pharmacognosy Magazine 10(39):622\u2013622","journal-title":"Pharmacognosy Magazine"},{"issue":"4","key":"12751_CR38","first-page":"5258","volume":"17","author":"HJ Yu","year":"2018","unstructured":"Yu HJ, Ahn CH, Yang IH, Won DH, Jin B, Cho NP, Cho SD (2018) Apoptosis induced by methanol extract of Potentilla discolor in human mucoepidermoid carcinoma cells through STAT3\/PUMA signaling axis. Mol Med Rep 17(4):5258\u20135264","journal-title":"Mol Med Rep"},{"issue":"4","key":"12751_CR39","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1038\/sj.bjc.6605788","volume":"103","author":"B Lujan","year":"2010","unstructured":"Lujan B, Hakim S, Moyano S, Nadal A, Caballero M, Diaz A, Alos L (2010) Activation of the EGFR\/ERK pathway in high-grade mucoepidermoid carcinomas of the salivary glands. Br J Cancer 103(4):510\u2013516","journal-title":"Br J Cancer"},{"issue":"12","key":"12751_CR40","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1038\/s41419-019-2150-8","volume":"10","author":"RJ Carter","year":"2019","unstructured":"Carter RJ, Milani M, Butterworth M, Alotibi A, Harper N, Yedida G, Varadarajan S (2019) Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck. Cell Death Dis 10(12):912","journal-title":"Cell Death Dis"},{"issue":"1","key":"12751_CR41","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s13045-021-01079-1","volume":"14","author":"H Wang","year":"2021","unstructured":"Wang H, Guo M, Wei H, Chen Y (2021) Targeting MCL-1 in cancer: current status and perspectives. J Hematol Oncol 14(1):67","journal-title":"J Hematol Oncol"},{"issue":"6","key":"12751_CR42","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.tripleo.2008.12.052","volume":"107","author":"NG Nikitakis","year":"2009","unstructured":"Nikitakis NG, Scheper MA, Papanikolaou VS, Sklavounou A, Sauk JJ (2009) Immunohistochemical expression of the oncogenic molecules active Stat3 and survivin in benign and malignant salivary gland tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107(6):837\u2013843","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"9","key":"12751_CR43","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1007\/s00109-018-1670-5","volume":"96","author":"L Gao","year":"2018","unstructured":"Gao L, Zhao X, Lang L, Shay C, Yeudall A, W., Teng Y (2018) Autophagy blockade sensitizes human head and neck squamous cell carcinoma towards CYT997 through enhancing excessively high reactive oxygen species-induced apoptosis. J Mol Med 96(9):929\u2013938","journal-title":"J Mol Med"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12751-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12751-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12751-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:02:17Z","timestamp":1789167737000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12751-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12751"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12751-5","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]},"assertion":[{"value":"3 August 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Clinical Trial Number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent to Publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Ethics and Consent to Participate Declarations","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":5,"name":"Ethics","label":"Institutional Review Board Statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":6,"name":"Ethics","label":"Informed Consent Statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Illustrae.co (accessed July 2026) was used solely to assist with the graphical rendering of the conceptual and mechanistic figures. The authors independently defined all scientific concepts, mechanisms, pathways, relationships, labels, graphical logic, and interpretations represented in these figures. Illustrae.co generated or refined graphical elements based on detailed instructions provided by the authors but was not used to originate, infer, or independently develop any scientific concept, mechanism, relationship, interpretation, or conclusion presented in the figures. All AI-assisted visual outputs were critically reviewed, corrected, edited, and approved by the authors to ensure scientific accuracy and consistency with the cited literature. The authors take full responsibility for the accuracy, integrity, and scientific validity of all content presented in the manuscript. During the preparation of this manuscript, the authors used ChatGPT (GPT-5.6, OpenAI 2026) solely to refine author-written text for grammar, readability, clarity, and conciseness. ChatGPT was not used for data extraction or analysis, scientific interpretation, development of scientific concepts or mechanisms, or formulation of the conclusions. All scientific content, literature synthesis, interpretations, and conclusions were independently developed and verified by the authors. No generative artificial intelligence tool was used to generate, populate, structure, classify, or scientifically interpret the tables. All information presented in the tables was manually compiled from the cited literature and critically verified by the authors.","order":7,"name":"Ethics","label":"Use of AI-Assisted Technology Declaration","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1563"}}