{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:49:18Z","timestamp":1792673358597,"version":"4.5.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"The Academic Leaders Training Program of Shanghai Pudong New Area Health Commission","award":["No.PWRd2024-12"],"award-info":[{"award-number":["No.PWRd2024-12"]}]},{"name":"The Academic Leaders Training Program of Shanghai Pudong New Area Health Commission","award":["No.PWRd2024-12"],"award-info":[{"award-number":["No.PWRd2024-12"]}]},{"name":"The Academic Leaders Training Program of Shanghai Pudong New Area Health Commission","award":["No.PWRd2024-12"],"award-info":[{"award-number":["No.PWRd2024-12"]}]},{"name":"The Academic Leaders Training Program of Shanghai Pudong New Area Health Commission","award":["No.PWRd2024-12"],"award-info":[{"award-number":["No.PWRd2024-12"]}]},{"name":"The Academic Leaders Training Program of Shanghai Pudong New Area Health Commission","award":["No.PWRd2024-12"],"award-info":[{"award-number":["No.PWRd2024-12"]}]},{"name":"The Academic Leaders Training Program of Shanghai Pudong New Area Health Commission","award":["No.PWRd2024-12"],"award-info":[{"award-number":["No.PWRd2024-12"]}]},{"name":"The Academic Leaders Training Program of Shanghai Pudong New Area Health Commission","award":["No.PWRd2024-12"],"award-info":[{"award-number":["No.PWRd2024-12"]}]},{"name":"The Academic Leaders Training Program of Shanghai Pudong New Area Health Commission","award":["No.PWRd2024-12"],"award-info":[{"award-number":["No.PWRd2024-12"]}]},{"name":"The Project of Key Medical Discipline Group Construction in Shanghai Pudong New Area","award":["No. PWZxq2022-13"],"award-info":[{"award-number":["No. PWZxq2022-13"]}]},{"name":"The Project of Key Medical Discipline Group Construction in Shanghai Pudong New Area","award":["No. PWZxq2022-13"],"award-info":[{"award-number":["No. PWZxq2022-13"]}]},{"name":"The Project of Key Medical Discipline Group Construction in Shanghai Pudong New Area","award":["No. PWZxq2022-13"],"award-info":[{"award-number":["No. PWZxq2022-13"]}]},{"name":"The Project of Key Medical Discipline Group Construction in Shanghai Pudong New Area","award":["No. PWZxq2022-13"],"award-info":[{"award-number":["No. PWZxq2022-13"]}]},{"name":"The Project of Key Medical Discipline Group Construction in Shanghai Pudong New Area","award":["No. PWZxq2022-13"],"award-info":[{"award-number":["No. PWZxq2022-13"]}]},{"name":"The Project of Key Medical Discipline Group Construction in Shanghai Pudong New Area","award":["No. PWZxq2022-13"],"award-info":[{"award-number":["No. PWZxq2022-13"]}]},{"name":"The Project of Key Medical Discipline Group Construction in Shanghai Pudong New Area","award":["No. PWZxq2022-13"],"award-info":[{"award-number":["No. PWZxq2022-13"]}]},{"name":"The Project of Key Medical Discipline Group Construction in Shanghai Pudong New Area","award":["No. PWZxq2022-13"],"award-info":[{"award-number":["No. PWZxq2022-13"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12794-8","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:32:14Z","timestamp":1792672334000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CLU attenuates sepsis-associated acute lung injury by inhibiting Bax-mediated mitochondrial damage"],"prefix":"10.1007","volume":"53","author":[{"given":"Song","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conghui","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"issue":"4","key":"12794_CR1","first-page":"334","volume":"1","author":"D Anggraini","year":"2022","unstructured":"Anggraini D, Hasni D, Amelia R (2022) Pathogenesis of sepsis. Sci J 1(4):334\u2013341","journal-title":"Sci J"},{"issue":"11","key":"12794_CR2","doi-asserted-by":"publisher","first-page":"2450","DOI":"10.1016\/j.immuni.2021.10.012","volume":"54","author":"T van der Poll","year":"2021","unstructured":"van der Poll T, Shankar-Hari M, Wiersinga WJ (2021) The immunology of sepsis. Immunity 54(11):2450\u20132464","journal-title":"Immunity"},{"key":"12794_CR3","doi-asserted-by":"publisher","first-page":"1289194","DOI":"10.3389\/fmed.2023.1289194","volume":"10","author":"B Sun","year":"2023","unstructured":"Sun B, Lei M, Zhang J, Kang H, Liu H, Zhou F (2023) Acute lung injury caused by sepsis: how does it happen? Front Med 10:1289194","journal-title":"Front Med"},{"issue":"1","key":"12794_CR4","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1186\/s12964-024-01620-y","volume":"22","author":"X Qiao","year":"2024","unstructured":"Qiao X, Yin J, Zheng Z, Li L, Feng X (2024) Endothelial cell dynamics in sepsis-induced acute lung injury and acute respiratory distress syndrome: pathogenesis and therapeutic implications. Cell Communication Signal 22(1):241","journal-title":"Cell Communication Signal"},{"issue":"6","key":"12794_CR5","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.3390\/life13061240","volume":"13","author":"G Miserocchi","year":"2023","unstructured":"Miserocchi G (2023) Early endothelial signaling transduction in developing lung edema. Life 13(6):1240","journal-title":"Life"},{"issue":"11","key":"12794_CR6","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.3390\/antiox10111824","volume":"10","author":"G Napolitano","year":"2021","unstructured":"Napolitano G, Fasciolo G, Venditti P (2021) Mitochondrial management of reactive oxygen species. Antioxidants 10(11):1824","journal-title":"Antioxidants"},{"key":"12794_CR7","doi-asserted-by":"publisher","first-page":"tkad029","DOI":"10.1093\/burnst\/tkad029","volume":"11","author":"HS Prabhakaran","year":"2023","unstructured":"Prabhakaran HS, Hu D, He W, Luo G, Liou Y-C (2023) Mitochondrial dysfunction and mitophagy: crucial players in burn trauma and wound healing. Burns Trauma 11:tkad029","journal-title":"Burns Trauma"},{"key":"12794_CR8","doi-asserted-by":"publisher","first-page":"1167886","DOI":"10.3389\/fnagi.2023.1167886","volume":"15","author":"G Milinkeviciute","year":"2023","unstructured":"Milinkeviciute G, Green KN (2023) Clusterin\/apolipoprotein J, its isoforms and Alzheimer\u2019s disease. Front Aging Neurosci 15:1167886","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"12794_CR9","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/s41420-023-01766-7","volume":"9","author":"M Cao","year":"2023","unstructured":"Cao M, Wang G, Xie J (2023) Immune dysregulation in sepsis: experiences, lessons and perspectives. Cell death discovery 9(1):465","journal-title":"Cell death discovery"},{"issue":"1","key":"12794_CR10","first-page":"6362344","volume":"2022","author":"W Li","year":"2022","unstructured":"Li W, Li D, Chen Y, Abudou H, Wang H, Cai J et al (2022) Classic signaling pathways in alveolar injury and repair involved in sepsis-induced ALI\/ARDS: new research progress and prospect. Dis Markers 2022(1):6362344","journal-title":"Dis Markers"},{"key":"12794_CR11","doi-asserted-by":"crossref","unstructured":"Sun N, Lin C-H, Li MY, Wang Y, Chen D, Ren X et al (2025) Clusterin drives myeloid bias in aged hematopoietic stem cells by regulating mitochondrial function. Nat Aging 5:1510\u20131527.","DOI":"10.1038\/s43587-025-00908-z"},{"issue":"1","key":"12794_CR12","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s42269-020-00284-1","volume":"44","author":"ZW Atwan","year":"2020","unstructured":"Atwan ZW (2020) GAPDH spike RNA as an alternative for housekeeping genes in relative gene expression assay using real-time PCR. Bull Natl Res Centre 44(1):32","journal-title":"Bull Natl Res Centre"},{"issue":"5","key":"12794_CR13","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1007\/s10238-022-00885-2","volume":"23","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Lv X, Chen L, Liu Y (2023) The role and function of CLU in cancer biology and therapy. Clin experimental Med 23(5):1375\u20131391","journal-title":"Clin experimental Med"},{"key":"12794_CR14","doi-asserted-by":"crossref","unstructured":"He S, Pan T, Tian R, He Q, Cheng D, Qu H et al (2025) Fatty acid synthesis promotes mtDNA release via ETS1-mediated oligomerization of VDAC1 facilitating endothelial dysfunction in sepsis-induced lung injury. Cell Death Differ 32:2177\u20132192.","DOI":"10.1038\/s41418-025-01524-5"},{"key":"12794_CR15","doi-asserted-by":"publisher","first-page":"110795","DOI":"10.1016\/j.intimp.2023.110795","volume":"123","author":"C An","year":"2023","unstructured":"An C, Sun F, Liu C, Huang S, Xu T, Zhang C et al (2023) IQGAP1 promotes mitochondrial damage and activation of the mtDNA sensor cGAS-STING pathway to induce endothelial cell pyroptosis leading to atherosclerosis. Int Immunopharmacol 123:110795","journal-title":"Int Immunopharmacol"},{"key":"12794_CR16","doi-asserted-by":"crossref","unstructured":"Bhandari N, Devi YG, Acharya D, Bhat V, Chatterjee A, Yalshetti S, et al (2026) MRPL47 deficiency drives mitochondrial dysfunction via ROS-p38-p21 signaling in non-small cell lung cancer. J Biol Chem 302(2):111058.","DOI":"10.1016\/j.jbc.2025.111058"},{"issue":"5","key":"12794_CR17","doi-asserted-by":"publisher","first-page":"714","DOI":"10.2174\/092986712798992110","volume":"19","author":"V Shoshan-Barmatz","year":"2012","unstructured":"Shoshan-Barmatz V, Golan M (2012) Mitochondrial VDAC1: function in cell life and death and a target for cancer therapy. Curr Med Chem 19(5):714\u2013735","journal-title":"Curr Med Chem"},{"issue":"10","key":"12794_CR18","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1038\/s41419-020-03031-6","volume":"11","author":"B Li","year":"2020","unstructured":"Li B, Li A, You Z, Xu J, Zhu S (2020) Epigenetic silencing of CDKN1A and CDKN2B by SNHG1 promotes the cell cycle, migration and epithelial-mesenchymal transition progression of hepatocellular carcinoma. Cell Death Dis 11(10):823","journal-title":"Cell Death Dis"},{"issue":"10","key":"12794_CR19","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1089\/ars.2011.4085","volume":"16","author":"VG Antico Arciuch","year":"2012","unstructured":"Antico Arciuch VG, Elguero ME, Poderoso JJ, Carreras MC (2012) Mitochondrial regulation of cell cycle and proliferation. Antioxid Redox Signal 16(10):1150\u20131180","journal-title":"Antioxid Redox Signal"},{"key":"12794_CR20","doi-asserted-by":"publisher","first-page":"1062293","DOI":"10.3389\/fgene.2022.1062293","volume":"13","author":"G Guo","year":"2022","unstructured":"Guo G, Wang Y, Kou W, Gan H (2022) Identifying the molecular mechanisms of sepsis-associated acute kidney injury and predicting potential drugs. Front Genet 13:1062293","journal-title":"Front Genet"},{"issue":"9","key":"12794_CR21","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1097\/CM9.0000000000002065","volume":"135","author":"Q Zhang","year":"2022","unstructured":"Zhang Q, Yue Y, Zheng R (2022) Clusterin as a serum biomarker candidate contributes to the lung fibroblasts activation in chronic obstructive pulmonary disease. Chin Med J 135(9):1076\u20131086","journal-title":"Chin Med J"},{"issue":"11","key":"12794_CR22","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1158\/1541-7786.MCR-18-0070","volume":"16","author":"X Ming","year":"2018","unstructured":"Ming X, Bao C, Hong T, Yang Y, Chen X, Jung Y-S et al (2018) Clusterin, a novel DEC1 target, modulates DNA damage\u2013Mediated cell death. Mol Cancer Res 16(11):1641\u20131651","journal-title":"Mol Cancer Res"},{"issue":"1","key":"12794_CR23","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3892\/mmr.2025.13741","volume":"33","author":"L Zhang","year":"2025","unstructured":"Zhang L, Li H, Li D, Dai Q (2025) Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives. Mol Med Rep 33(1):31","journal-title":"Mol Med Rep"},{"issue":"6","key":"12794_CR24","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1080\/15548627.2024.2309904","volume":"20","author":"PP Praharaj","year":"2024","unstructured":"Praharaj PP, Patra S, Singh A, Panigrahi DP, Lee HY, Kabir MF et al (2024) CLU (clusterin) and PPARGC1A\/PGC1\u03b1 coordinately control mitophagy and mitochondrial biogenesis for oral cancer cell survival. Autophagy 20(6):1359\u20131382","journal-title":"Autophagy"},{"issue":"4","key":"12794_CR25","doi-asserted-by":"publisher","first-page":"944","DOI":"10.3390\/cells10040944","volume":"10","author":"JY Hong","year":"2021","unstructured":"Hong JY, Kim MN, Kim EG, Lee JW, Kim HR, Kim SY et al (2021) Clusterin deficiency exacerbates hyperoxia-induced acute lung injury. Cells 10(4):944","journal-title":"Cells"},{"issue":"1","key":"12794_CR26","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s13613-021-00893-7","volume":"11","author":"S Preau","year":"2021","unstructured":"Preau S, Vodovar D, Jung B, Lancel S, Zafrani L, Flatres A et al (2021) Energetic dysfunction in sepsis: a narrative review. Ann Intensiv Care 11(1):104","journal-title":"Ann Intensiv Care"},{"issue":"3","key":"12794_CR27","doi-asserted-by":"publisher","first-page":"139","DOI":"10.5492\/wjccm.v12.i3.139","volume":"12","author":"W Nedel","year":"2023","unstructured":"Nedel W, Deutschendorf C, Portela LVC (2023) Sepsis-induced mitochondrial dysfunction: A narrative review. World J Crit Care Med 12(3):139","journal-title":"World J Crit Care Med"},{"issue":"1","key":"12794_CR28","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1158\/1078-0432.CCR-08-1805","volume":"15","author":"IP Trougakos","year":"2009","unstructured":"Trougakos IP, Lourda M, Antonelou MH, Kletsas D, Gorgoulis VG, Papassideri IS et al (2009) Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex. Clin Cancer Res 15(1):48\u201359","journal-title":"Clin Cancer Res"},{"key":"12794_CR29","doi-asserted-by":"publisher","first-page":"111326","DOI":"10.1016\/j.ecoenv.2020.111326","volume":"205","author":"S Tang","year":"2020","unstructured":"Tang S, Ye S, Ma Y, Liang Y, Liang N, Xiao F (2020) Clusterin alleviates Cr (VI)-induced mitochondrial apoptosis in L02 hepatocytes via inhibition of Ca2+-ROS-Drp1-mitochondrial fission axis. Ecotoxicol Environ Saf 205:111326","journal-title":"Ecotoxicol Environ Saf"},{"issue":"1","key":"12794_CR30","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s13054-020-03424-1","volume":"25","author":"EC van der Slikke","year":"2021","unstructured":"van der Slikke EC, Star BS, van Meurs M, Henning RH, Moser J, Bouma HR (2021) Sepsis is associated with mitochondrial DNA damage and a reduced mitochondrial mass in the kidney of patients with sepsis-AKI. Crit Care 25(1):36","journal-title":"Crit Care"},{"issue":"6","key":"12794_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/ijmm.2022.5141","volume":"49","author":"C Li","year":"2022","unstructured":"Li C, Ma D, Chen Y, Liu W, Jin F, Bo L (2022) Selective inhibition of JNK located on mitochondria protects against mitochondrial dysfunction and cell death caused by endoplasmic reticulum stress in mice with LPS\u2013induced ALI\/ARDS. Int J Mol Med 49(6):1\u201315","journal-title":"Int J Mol Med"},{"issue":"1","key":"12794_CR32","doi-asserted-by":"publisher","first-page":"4700","DOI":"10.1038\/s41467-024-49067-6","volume":"15","author":"S Dadsena","year":"2024","unstructured":"Dadsena S, Cuevas Arenas R, Vieira G, Brodesser S, Melo MN, Garc\u00eda-S\u00e1ez AJ (2024) Lipid unsaturation promotes BAX and BAK pore activity during apoptosis. Nat Commun 15(1):4700","journal-title":"Nat Commun"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12794-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12794-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12794-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:32:15Z","timestamp":1792672335000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12794-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,22]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12794"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12794-8","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,22]]},"assertion":[{"value":"9 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1786"}}