{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:06:21Z","timestamp":1790766381162,"version":"4.1.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12829-0","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:42:50Z","timestamp":1790764970000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Salivary miRNAs along with p53 and EGFR in oral exfoliated cells: a pilot study on candidate noninvasive biomarkers for the early detection of oral cancer in tobacco users"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7717-2204","authenticated-orcid":false,"given":"Ravina","family":"Vats","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5419-8337","authenticated-orcid":false,"given":"Pooja","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8627-6961","authenticated-orcid":false,"given":"Afsareen","family":"Bano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6584-5017","authenticated-orcid":false,"given":"Amit","family":"Vashishtha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7468-7886","authenticated-orcid":false,"given":"Anjali","family":"Narwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7045-0830","authenticated-orcid":false,"given":"Rashmi","family":"Bhardwaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"12829_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/CAAC.21834","volume":"74","author":"BF Bray","year":"2024","unstructured":"Bray BF, Laversanne, Hyuna M et al (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74:229\u2013263. https:\/\/doi.org\/10.3322\/CAAC.21834","journal-title":"CA Cancer J Clin"},{"key":"12829_CR2","doi-asserted-by":"publisher","first-page":"324","DOI":"10.4103\/NJMS.NJMS_130_20","volume":"12","author":"A Chaurasia","year":"2021","unstructured":"Chaurasia A, Alam SI, Singh N (2021) Oral cancer diagnostics: An overview. Natl J Maxillofac Surg 12:324. https:\/\/doi.org\/10.4103\/NJMS.NJMS_130_20","journal-title":"Natl J Maxillofac Surg"},{"key":"12829_CR3","doi-asserted-by":"publisher","unstructured":"Singh SR, Bhaskar R, Ghosh S et al (2025) Exploring the Genetic Orchestra of Cancer: The Interplay Between Oncogenes and Tumor-Suppressor Genes. Cancers 17:1082. https:\/\/doi.org\/10.3390\/CANCERS17071082","DOI":"10.3390\/CANCERS17071082"},{"key":"12829_CR4","doi-asserted-by":"publisher","DOI":"10.1101\/CSHPERSPECT.A003236","author":"EYHP Lee","year":"2010","unstructured":"Lee EYHP, Muller WJ (2010) Oncogenes and tumor suppressor genes. Cold Spring Harb Perspect Biol. https:\/\/doi.org\/10.1101\/CSHPERSPECT.A003236. 2:","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"12829_CR5","doi-asserted-by":"publisher","first-page":"105108","DOI":"10.1016\/J.ARCHORALBIO.2021.105108","volume":"125","author":"N Al Rawi","year":"2021","unstructured":"Al Rawi N, Elmabrouk N, Abu Kou R et al (2021) The role of differentially expressed salivary microRNA in oral squamous cell carcinoma. A systematic review. Arch Oral Biol 125:105108. https:\/\/doi.org\/10.1016\/J.ARCHORALBIO.2021.105108","journal-title":"Arch Oral Biol"},{"key":"12829_CR6","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1177\/154405910408300303","volume":"83","author":"Y Li","year":"2004","unstructured":"Li Y, Zhou X, St. John MAR, Wong DTW (2004) RNA profiling of cell-free saliva using microarray technology. J Dent Res 83:199\u2013203. https:\/\/doi.org\/10.1177\/154405910408300303","journal-title":"J Dent Res"},{"key":"12829_CR7","doi-asserted-by":"publisher","first-page":"86S","DOI":"10.1177\/0022034514531018","volume":"93","author":"F Momen-Heravi","year":"2014","unstructured":"Momen-Heravi F, Trachtenberg AJ, Kuo WP, Cheng YS (2014) Genomewide Study of Salivary MicroRNAs for Detection of Oral Cancer. J Dent Res 93:86S. https:\/\/doi.org\/10.1177\/0022034514531018","journal-title":"J Dent Res"},{"key":"12829_CR8","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2059240","author":"BSMS Siriwardena","year":"2020","unstructured":"Siriwardena BSMS, Karunathilaka HDNU, Kumarasiri PVR, Tilakaratne WM (2020) Impact of Histological and Molecular Parameters on Prognosis of Oral Squamous Cell Carcinoma: Analysis of 290 Cases. Biomed Res Int 2020. https:\/\/doi.org\/10.1155\/2020\/2059240","journal-title":"Biomed Res Int 2020"},{"key":"12829_CR9","doi-asserted-by":"publisher","unstructured":"Salazar-Ruales C, Arguello JV, L\u00f3pez-Cort\u00e9s A et al (2018) Salivary MicroRNAs for Early Detection of Head and Neck Squamous Cell Carcinoma: A Case-Control Study in the High Altitude Mestizo Ecuadorian Population. Biomed Res Int. https:\/\/doi.org\/10.1155\/2018\/9792730","DOI":"10.1155\/2018\/9792730"},{"key":"12829_CR10","doi-asserted-by":"publisher","unstructured":"Rajan C, Roshan VGD, Khan I et al (2021) MiRNA expression profiling and emergence of new prognostic signature for oral squamous cell carcinoma. Scientific Reports 11:1\u201312. https:\/\/doi.org\/10.1038\/s41598-021-86316-w","DOI":"10.1038\/s41598-021-86316-w"},{"key":"12829_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.105002","author":"S Yete","year":"2020","unstructured":"Yete S, Saranath D (2020) MicroRNAs in oral cancer: Biomarkers with clinical potential. Oral Oncol. https:\/\/doi.org\/10.1016\/j.oraloncology.2020.105002. 110:","journal-title":"Oral Oncol"},{"key":"12829_CR12","doi-asserted-by":"publisher","first-page":"823","DOI":"10.3390\/CANCERS14030823","volume":"14","author":"JE Zawacka-Pankau","year":"2022","unstructured":"Zawacka-Pankau JE (2022) The Role of p53 Family in Cancer. Cancers (Basel) 14:823. https:\/\/doi.org\/10.3390\/CANCERS14030823","journal-title":"Cancers (Basel)"},{"key":"12829_CR13","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.gene.2005.10.018","volume":"366","author":"N Normanno","year":"2006","unstructured":"Normanno N, De Luca A, Bianco C et al (2006) Epidermal growth factor receptor (EGFR) signaling in cancer. Gene 366:2\u201316. https:\/\/doi.org\/10.1016\/j.gene.2005.10.018","journal-title":"Gene"},{"key":"12829_CR14","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1080\/14728222.2023.2218613","volume":"27","author":"S Halder","year":"2023","unstructured":"Halder S, Basu S, Lall SP et al (2023) Targeting the EGFR signaling pathway in cancer therapy: What\u2019s new in 2023? Expert Opin Ther Targets 27:305. https:\/\/doi.org\/10.1080\/14728222.2023.2218613","journal-title":"Expert Opin Ther Targets"},{"key":"12829_CR15","doi-asserted-by":"publisher","unstructured":"Di Stasio D, Romano A, Boschetti CE et al (2022) Salivary miRNAs Expression in Potentially Malignant Disorders of the Oral Mucosa and Oral Squamous Cell Carcinoma: A Pilot Study on miR-21, miR-27b, and miR-181b. Cancers (Basel) 15. https:\/\/doi.org\/10.3390\/CANCERS15010291","DOI":"10.3390\/CANCERS15010291"},{"key":"12829_CR16","doi-asserted-by":"publisher","unstructured":"Rebaudi F, De Rosa A, Greppi M et al (2023) A new method for oral cancer biomarkers detection with a non-invasive cyto-salivary sampling and rapid-highly sensitive ELISA immunoassay: a pilot study in humans. Front Immunol 14. https:\/\/doi.org\/10.3389\/FIMMU.2023.1216107","DOI":"10.3389\/FIMMU.2023.1216107"},{"key":"12829_CR17","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/s41368-023-00273-w","volume":"16","author":"J Balakittnen","year":"2024","unstructured":"Balakittnen J, Ekanayake Weeramange C, Wallace DF et al (2024) A novel saliva-based miRNA profile to diagnose and predict oral cancer. Int J Oral Sci 16:14. https:\/\/doi.org\/10.1038\/s41368-023-00273-w","journal-title":"Int J Oral Sci"},{"key":"12829_CR18","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.oraloncology.2016.03.017","volume":"57","author":"Q He","year":"2016","unstructured":"He Q, Chen Z, Cabay RJ et al (2016) microRNA-21 and microRNA-375 from oral cytology as biomarkers for oral tongue cancer detection. Oral Oncol 57:15\u201320. https:\/\/doi.org\/10.1016\/j.oraloncology.2016.03.017","journal-title":"Oral Oncol"},{"key":"12829_CR19","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.yexmp.2010.06.004","volume":"89","author":"SMD Prado","year":"2010","unstructured":"Prado SMD, Cedr\u00fan JLL, Rey RL et al (2010) Evaluation of COX-2, EGFR, and p53 as biomarkers of non-dysplastic oral leukoplakias. Exp Mol Pathol 89:197\u2013203. https:\/\/doi.org\/10.1016\/j.yexmp.2010.06.004","journal-title":"Exp Mol Pathol"},{"key":"12829_CR20","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1080\/15384047.2015.1070985","volume":"16","author":"S Gupta","year":"2015","unstructured":"Gupta S, Khan H, Kushwaha VS et al (2015) Impact of EGFR and p53 expressions on survival and quality of life in locally advanced oral squamous cell carcinoma patients treated with chemoradiation. Cancer Biol Ther 16:1269. https:\/\/doi.org\/10.1080\/15384047.2015.1070985","journal-title":"Cancer Biol Ther"},{"key":"12829_CR21","doi-asserted-by":"publisher","unstructured":"Johnson DE, Burtness B, Leemans CR et al (2020) Head and neck squamous cell carcinoma. Nature Reviews Disease Primers 6:1\u201322. https:\/\/doi.org\/10.1038\/s41572-020-00224-3","DOI":"10.1038\/s41572-020-00224-3"},{"key":"12829_CR22","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.3390\/BIOMEDICINES9091079\/S1","volume":"9","author":"N Mehterov","year":"2021","unstructured":"Mehterov N, Vladimirov B, Sacconi A et al (2021) Salivary miR-30c-5p as potential biomarker for detection of oral squamous cell carcinoma. Biomedicines 9:1079. https:\/\/doi.org\/10.3390\/BIOMEDICINES9091079\/S1","journal-title":"Biomedicines"},{"key":"12829_CR23","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1111\/ODI.12340","volume":"21","author":"F Zahran","year":"2015","unstructured":"Zahran F, Ghalwash D, Shaker O et al (2015) Salivary microRNAs in oral cancer. Oral Dis 21:739\u2013747. https:\/\/doi.org\/10.1111\/ODI.12340","journal-title":"Oral Dis"},{"key":"12829_CR24","doi-asserted-by":"publisher","unstructured":"Scholtz B, Horv\u00e1th J, Tar I et al (2022) Salivary miR-31-5p, miR-345-3p, and miR-424-3p Are Reliable Biomarkers in Patients with Oral Squamous Cell Carcinoma. https:\/\/doi.org\/10.3390\/PATHOGENS11020229. Pathogens 11:","DOI":"10.3390\/PATHOGENS11020229"},{"key":"12829_CR25","doi-asserted-by":"publisher","unstructured":"Mehdipour M, Shahidi M, Anbari F et al (2023) Salivary level of microRNA-146a and microRNA-155 biomarkers in patients with oral lichen planus versus oral squamous cell carcinoma. BMC Oral Health 23. https:\/\/doi.org\/10.1186\/S12903-023-03155-Z","DOI":"10.1186\/S12903-023-03155-Z"},{"key":"12829_CR26","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1002\/GCC.20666","volume":"48","author":"BJ Henson","year":"2009","unstructured":"Henson BJ, Bhattacharjee S, O\u2019Dee DM et al (2009) Decreased Expression of miR-125b and miR-100 in Oral Cancer Cells Contributes to Malignancy. Genes Chromosomes Cancer 48:569. https:\/\/doi.org\/10.1002\/GCC.20666","journal-title":"Genes Chromosomes Cancer"},{"key":"12829_CR27","doi-asserted-by":"publisher","first-page":"5296","DOI":"10.7150\/JCA.56138","volume":"12","author":"JE Jung","year":"2021","unstructured":"Jung JE, Lee JY, Park HR et al (2021) MicroRNA-133 Targets Phosphodiesterase 1C in Drosophila and Human Oral Cancer Cells to Regulate Epithelial-Mesenchymal Transition. J Cancer 12:5296\u20135309. https:\/\/doi.org\/10.7150\/JCA.56138","journal-title":"J Cancer"},{"key":"12829_CR28","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1186\/S12935-022-02676-X","volume":"22","author":"S Ghafouri-Fard","year":"2022","unstructured":"Ghafouri-Fard S, Noie Alamdari A, Noee Alamdari Y et al (2022) Role of PI3K\/AKT pathway in squamous cell carcinoma with an especial focus on head and neck cancers. Cancer Cell Int 22:254. https:\/\/doi.org\/10.1186\/S12935-022-02676-X","journal-title":"Cancer Cell Int"},{"key":"12829_CR29","doi-asserted-by":"publisher","first-page":"e002","DOI":"10.1590\/1807-3107BOR-2020.VOL34.0002","volume":"34","author":"TN Uma Maheswari","year":"2020","unstructured":"Uma Maheswari TN, Nivedhitha MS, Ramani P (2020) Expression profile of salivary micro RNA-21 and 31 in oral potentially malignant disorders. Braz Oral Res 34:e002. https:\/\/doi.org\/10.1590\/1807-3107BOR-2020.VOL34.0002","journal-title":"Braz Oral Res"},{"key":"12829_CR30","doi-asserted-by":"publisher","unstructured":"Koopaie M, Abedinejad F, Manifar S et al (2021) Salivary miRNA-21 expression as a potential non-invasive diagnostic biomarker in breast cancer. Gene Rep 25. https:\/\/doi.org\/10.1016\/j.genrep.2021.101317","DOI":"10.1016\/j.genrep.2021.101317"},{"key":"12829_CR31","doi-asserted-by":"publisher","first-page":"19","DOI":"10.2147\/LCTT.S60341","volume":"7","author":"A Markou","year":"2016","unstructured":"Markou A, Zavridou M, Lianidou ES (2016) miRNA-21 as a novel therapeutic target in lung cancer. Lung Cancer: Targets Therapy 7:19. https:\/\/doi.org\/10.2147\/LCTT.S60341","journal-title":"Lung Cancer: Targets Therapy"},{"key":"12829_CR32","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/S12253-013-9689-Y","volume":"20","author":"A Kawakita","year":"2014","unstructured":"Kawakita A, Yanamoto S, Yamada SI et al (2014) MicroRNA-21 promotes oral cancer invasion via the Wnt\/\u03b2-catenin pathway by targeting DKK2. Pathol Oncol Res 20:253\u2013261. https:\/\/doi.org\/10.1007\/S12253-013-9689-Y","journal-title":"Pathol Oncol Res"},{"key":"12829_CR33","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/J.OMTN.2020.03.003","volume":"20","author":"D Bautista-S\u00e1nchez","year":"2020","unstructured":"Bautista-S\u00e1nchez D, Arriaga-Canon C, Pedroza-Torres A et al (2020) The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics. Mol Ther Nucleic Acids 20:409. https:\/\/doi.org\/10.1016\/J.OMTN.2020.03.003","journal-title":"Mol Ther Nucleic Acids"},{"key":"12829_CR34","doi-asserted-by":"publisher","unstructured":"Maheswari R, Urs AB, Kumar P et al (2024) Exploring miR-155-5p and miR-1246 as Diagnostic and Prognostic Markers in Oral Squamous cell carcinoma. Mol Biol Rep 51. https:\/\/doi.org\/10.1007\/S11033-024-09234-W","DOI":"10.1007\/S11033-024-09234-W"},{"key":"12829_CR35","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1111\/JOP.12351","volume":"45","author":"O Baba","year":"2016","unstructured":"Baba O, Hasegawa S, Nagai H et al (2016) MicroRNA-155-5p is associated with oral squamous cell carcinoma metastasis and poor prognosis. J Oral Pathol Med 45:248\u2013255. https:\/\/doi.org\/10.1111\/JOP.12351","journal-title":"J Oral Pathol Med"},{"issue":"1 25","key":"12829_CR36","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/S43042-024-00531-4","volume":"25","author":"N Mohtasham","year":"2024","unstructured":"Mohtasham N, Ghorbani Z, Ayatollahi H et al (2024) Serum mir-31-5p is a reliable biomarker in patients with oral squamous cell carcinoma and oral lichen planus. Egypt J Med Hum Genet 2024 25(1 25):77. https:\/\/doi.org\/10.1186\/S43042-024-00531-4","journal-title":"Egypt J Med Hum Genet 2024"},{"key":"12829_CR37","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1111\/ODI.12118","volume":"20","author":"MY Siow","year":"2014","unstructured":"Siow MY, Karen Ng LP, Vincent Chong VK et al (2014) Dysregulation of miR-31 and miR-375 expression is associated with clinical outcomes in oral carcinoma. Oral Dis 20:345\u2013351. https:\/\/doi.org\/10.1111\/ODI.12118","journal-title":"Oral Dis"},{"key":"12829_CR38","doi-asserted-by":"publisher","unstructured":"Lin X, Wu W, Ying Y et al (2022) MicroRNA-31: a pivotal oncogenic factor in oral squamous cell carcinoma. Cell Death Discovery 2022 8:1-140. https:\/\/doi.org\/10.1038\/s41420-022-00948-z","DOI":"10.1038\/s41420-022-00948-z"},{"key":"12829_CR39","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/j.oraloncology.2015.10.007","volume":"51","author":"YY Kao","year":"2015","unstructured":"Kao YY, Tu HF, Kao SY et al (2015) The increase of oncogenic miRNA expression in tongue carcinogenesis of a mouse model. Oral Oncol 51:1103\u20131112. https:\/\/doi.org\/10.1016\/j.oraloncology.2015.10.007","journal-title":"Oral Oncol"},{"key":"12829_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/IJMS21197232","volume":"21","author":"JE Jung","year":"2020","unstructured":"Jung JE, Lee JY, Kim IR et al (2020) MicroRNA-31 Regulates Expression of Wntless in Both Drosophila melanogaster and Human Oral Cancer Cells. Int J Mol Sci 21:1\u201320. https:\/\/doi.org\/10.3390\/IJMS21197232","journal-title":"Int J Mol Sci"},{"key":"12829_CR41","doi-asserted-by":"publisher","unstructured":"Sun YM, Lin KY, Chen YQ (2013) Diverse functions of miR-125 family in different cell contexts. J Hematol Oncol 6. https:\/\/doi.org\/10.1186\/1756-8722-6-6","DOI":"10.1186\/1756-8722-6-6"},{"key":"12829_CR42","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/S13402-018-0372-X","volume":"41","author":"M Mehdipour","year":"2018","unstructured":"Mehdipour M, Shahidi M, Manifar S et al (2018) Diagnostic and prognostic relevance of salivary microRNA-21, -125a, -31 and \u2013\u2009200a levels in patients with oral lichen planus - a short report. Cell Oncol (Dordrecht Netherlands) 41:329\u2013334. https:\/\/doi.org\/10.1007\/S13402-018-0372-X","journal-title":"Cell Oncol (Dordrecht Netherlands)"},{"key":"12829_CR43","doi-asserted-by":"publisher","unstructured":"Sharma G, Lamichhane S, Chae SC (2026) MIR133A in Cancer Biology: Target Genes, Biological Effects, and Biomarker Potential. Genes 17:781. https:\/\/doi.org\/10.3390\/GENES17070781","DOI":"10.3390\/GENES17070781"},{"key":"12829_CR44","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/S12291-022-01035-X","volume":"38","author":"S Ukey","year":"2023","unstructured":"Ukey S, Jain A, Dwivedi S et al (2023) Study of MicroRNA (miR-221-3p, miR-133a-3p, and miR-9-5p) Expressions in Oral Submucous Fibrosis and Squamous Cell Carcinoma. Indian J Clin Biochem 38:73\u201382. https:\/\/doi.org\/10.1007\/S12291-022-01035-X","journal-title":"Indian J Clin Biochem"},{"key":"12829_CR45","doi-asserted-by":"publisher","first-page":"12717","DOI":"10.26355\/EURREV_202012_24170","volume":"24","author":"J YANG","year":"2020","unstructured":"YANG J, WANG H, XU W et al (2020) Inhibition of miR-133b indicates poor prognosis and promotes progression of OSCC via SOX4. Eur Rev Med Pharmacol Sci 24:12717\u201312726. https:\/\/doi.org\/10.26355\/EURREV_202012_24170","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"12829_CR46","doi-asserted-by":"publisher","unstructured":"Zhu G, Pan C, Bei JX et al (2020) Mutant p53 in Cancer Progression and Targeted Therapies. Front Oncol 10. https:\/\/doi.org\/10.3389\/FONC.2020.595187","DOI":"10.3389\/FONC.2020.595187"},{"key":"12829_CR47","doi-asserted-by":"publisher","DOI":"10.3892\/IJMM.2024.5448","author":"ML Tornesello","year":"2025","unstructured":"Tornesello ML (2025) TP53 mutations in cancer: Molecular features and therapeutic opportunities (Review). Int J Mol Med 55. https:\/\/doi.org\/10.3892\/IJMM.2024.5448","journal-title":"Int J Mol Med 55"},{"key":"12829_CR48","doi-asserted-by":"publisher","first-page":"11888","DOI":"10.3390\/IJMS241511888\/S1","volume":"24","author":"JL C\u00edvico-Ortega","year":"2023","unstructured":"C\u00edvico-Ortega JL, Gonz\u00e1lez-Ruiz I, Ramos-Garc\u00eda P et al (2023) Prognostic and Clinicopathological Significance of Epidermal Growth Factor Receptor (EGFR) Expression in Oral Squamous Cell Carcinoma: Systematic Review and Meta-Analysis. Int J Mol Sci 24:11888. https:\/\/doi.org\/10.3390\/IJMS241511888\/S1","journal-title":"Int J Mol Sci"},{"key":"12829_CR49","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1111\/J.1600-0714.2012.01142.X","volume":"41","author":"LS Monteiro","year":"2012","unstructured":"Monteiro LS, Diniz-Freitas M, Garcia-Caballero T et al (2012) Combined cytoplasmic and membranous EGFR and p53 overexpression is a poor prognostic marker in early stage oral squamous cell carcinoma. J Oral Pathol Med 41:559\u2013567. https:\/\/doi.org\/10.1111\/J.1600-0714.2012.01142.X","journal-title":"J Oral Pathol Med"},{"key":"12829_CR50","doi-asserted-by":"publisher","first-page":"e15602","DOI":"10.7717\/PEERJ.15602\/SUPP-3","volume":"11","author":"G Yan","year":"2023","unstructured":"Yan G, Wang L (2023) Role of ELK1 in regulating colorectal cancer progression: miR-31-5p\/CDIP1 axis in CRC pathogenesis. PeerJ 11:e15602. https:\/\/doi.org\/10.7717\/PEERJ.15602\/SUPP-3","journal-title":"PeerJ"},{"key":"12829_CR51","doi-asserted-by":"publisher","unstructured":"Liu Q, Yu S, Zhao W et al (2018) EGFR-TKIs resistance via EGFR-independent signaling pathways. Mol Cancer 17. https:\/\/doi.org\/10.1186\/S12943-018-0793-1","DOI":"10.1186\/S12943-018-0793-1"},{"key":"12829_CR52","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/S12672-025-04362-6","volume":"17","author":"P Sun","year":"2026","unstructured":"Sun P, Zhang M, Wang S et al (2026) MiR-31 suppresses lung adenocarcinoma cell proliferation through CDK1 and E2F2-mediated cell cycle arrest. Discover Oncol 17:251. https:\/\/doi.org\/10.1007\/S12672-025-04362-6","journal-title":"Discover Oncol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12829-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12829-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12829-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:42:52Z","timestamp":1790764972000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12829-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12829"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12829-0","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"11 August 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1661"}}