{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:55:55Z","timestamp":1790553355318,"version":"4.1.0"},"reference-count":124,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.82608893"],"award-info":[{"award-number":["No.82608893"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.82374490"],"award-info":[{"award-number":["No.82374490"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Henan Provincial Traditional Chinese Medicine Scientific Research Special Project","award":["No.2025ZY1016,2022ZY2026, 2021ZY2010"],"award-info":[{"award-number":["No.2025ZY1016,2022ZY2026, 2021ZY2010"]}]},{"name":"Zhengzhou City Science and Technology People-Benefiting Program Project","award":["No. 2023KJHM0009"],"award-info":[{"award-number":["No. 2023KJHM0009"]}]},{"name":"Henan Provincial Young and Middle-aged Health Science and Technology Innovation Leading Talents Training Project","award":["No.LJRC2024020"],"award-info":[{"award-number":["No.LJRC2024020"]}]},{"name":"Program for Innovative Research Team (in Science and Technology) in University of Henan Province","award":["No. 24IRTSTHN040"],"award-info":[{"award-number":["No. 24IRTSTHN040"]}]},{"name":"Henan Provincial Key Research and Development Special Project","award":["No.241111311700"],"award-info":[{"award-number":["No.241111311700"]}]},{"name":"Henan Provincial Natural Science Foundation Project","award":["No.232300420269, 222300420486"],"award-info":[{"award-number":["No.232300420269, 222300420486"]}]},{"name":"the Henan Provincial Traditional Chinese Medicine Scientific Research Special Joint Co-construction Project","award":["No.2025LHZX2160"],"award-info":[{"award-number":["No.2025LHZX2160"]}]},{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["No.252102310454"],"award-info":[{"award-number":["No.252102310454"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12832-5","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:46:07Z","timestamp":1790505967000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glycolysis in bone remodeling: from energy supply to signaling regulation"],"prefix":"10.1007","volume":"53","author":[{"given":"Haoyi","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beibei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Dan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruobin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengchao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintao","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangzeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"12832_CR1","doi-asserted-by":"publisher","first-page":"114806","DOI":"10.1016\/j.colsurfb.2025.114806","volume":"254","author":"W Wei","year":"2025","unstructured":"Wei W, Wang Y, Sun G et al (2025) Prussian blue nanoparticles mitigate inflammatory osteolysis by reducing oxidative stress and enhancing endogenous antioxidant systems. Colloids Surf B Biointerfaces 254:114806. https:\/\/doi.org\/10.1016\/j.colsurfb.2025.114806","journal-title":"Colloids Surf B Biointerfaces"},{"key":"12832_CR2","doi-asserted-by":"publisher","first-page":"3943","DOI":"10.3390\/cells11233943","volume":"11","author":"RK Srivastava","year":"2022","unstructured":"Srivastava RK, Sapra L, Mishra PK (2022) Osteometabolism: Metabolic Alterations in Bone Pathologies. Cells 11:3943. https:\/\/doi.org\/10.3390\/cells11233943","journal-title":"Cells"},{"key":"12832_CR3","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/s41419-024-06475-2","volume":"15","author":"R Peng","year":"2024","unstructured":"Peng R, Dong Y, Zheng M et al (2024) IL-17 promotes osteoclast-induced bone loss by regulating glutamine-dependent energy metabolism. Cell Death Dis 15:111. https:\/\/doi.org\/10.1038\/s41419-024-06475-2","journal-title":"Cell Death Dis"},{"key":"12832_CR4","doi-asserted-by":"publisher","first-page":"691013","DOI":"10.3389\/fimmu.2021.691013","volume":"12","author":"Y Li","year":"2021","unstructured":"Li Y, Ling J, Jiang Q (2021) Inflammasomes in Alveolar Bone Loss. Front Immunol 12:691013. https:\/\/doi.org\/10.3389\/fimmu.2021.691013","journal-title":"Front Immunol"},{"key":"12832_CR5","doi-asserted-by":"publisher","first-page":"108108","DOI":"10.1016\/j.celrep.2020.108108","volume":"32","author":"W-C Lee","year":"2020","unstructured":"Lee W-C, Ji X, Nissim I, Long F (2020) Malic Enzyme Couples Mitochondria with Aerobic Glycolysis in Osteoblasts. Cell Rep 32:108108. https:\/\/doi.org\/10.1016\/j.celrep.2020.108108","journal-title":"Cell Rep"},{"key":"12832_CR6","doi-asserted-by":"publisher","first-page":"2392","DOI":"10.1002\/jbmr.1976","volume":"28","author":"Y Indo","year":"2013","unstructured":"Indo Y, Takeshita S, Ishii K-A et al (2013) Metabolic regulation of osteoclast differentiation and function. J Bone Miner Res 28:2392\u20132399. https:\/\/doi.org\/10.1002\/jbmr.1976","journal-title":"J Bone Miner Res"},{"key":"12832_CR7","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1126\/science.146.3650.1476","volume":"146","author":"WA Peck","year":"1964","unstructured":"Peck WA, Birge SJ, Fedak SA (1964) BONE CELLS: BIOCHEMICAL AND BIOLOGICAL STUDIES AFTER ENZYMATIC ISOLATION. Science 146:1476\u20131477. https:\/\/doi.org\/10.1126\/science.146.3650.1476","journal-title":"Science"},{"key":"12832_CR8","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/S0021-9258(18)60342-4","volume":"237","author":"DV Cohn","year":"1962","unstructured":"Cohn DV, Forscher BK (1962) Aerobic metabolism of glucose by bone. J Biol Chem 237:615\u2013618","journal-title":"J Biol Chem"},{"key":"12832_CR9","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1016\/S0021-9258(18)69506-7","volume":"235","author":"AB Borle","year":"1960","unstructured":"Borle AB, Nichols N, Nichols G (1960) Metabolic Studies of Bone in Vitro. J Biol Chem 235:1206\u20131210. https:\/\/doi.org\/10.1016\/S0021-9258(18)69506-7","journal-title":"J Biol Chem"},{"key":"12832_CR10","doi-asserted-by":"publisher","first-page":"e2301300","DOI":"10.1002\/advs.202301300","volume":"10","author":"J Wu","year":"2023","unstructured":"Wu J, Hu M, Jiang H et al (2023) Endothelial Cell-Derived Lactate Triggers Bone Mesenchymal Stem Cell Histone Lactylation to Attenuate Osteoporosis. Adv Sci (Weinh) 10:e2301300. https:\/\/doi.org\/10.1002\/advs.202301300","journal-title":"Adv Sci (Weinh)"},{"key":"12832_CR11","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/s41413-023-00251-2","volume":"11","author":"H Kim","year":"2023","unstructured":"Kim H, Takegahara N, Choi Y (2023) IgSF11-mediated phosphorylation of pyruvate kinase M2 regulates osteoclast differentiation and prevents pathological bone loss. Bone Res 11:17. https:\/\/doi.org\/10.1038\/s41413-023-00251-2","journal-title":"Bone Res"},{"key":"12832_CR12","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1002\/jbmr.4202","volume":"36","author":"J-M Lee","year":"2020","unstructured":"Lee J-M, Kim M-J, Lee SJ et al (2020) PDK2 Deficiency Prevents Ovariectomy-Induced Bone Loss in Mice by Regulating the RANKL-NFATc1 Pathway During Osteoclastogenesis. J Bone Miner Res 36:553\u2013566. https:\/\/doi.org\/10.1002\/jbmr.4202","journal-title":"J Bone Miner Res"},{"key":"12832_CR13","doi-asserted-by":"publisher","first-page":"23111","DOI":"10.1074\/jbc.M202487200","volume":"277","author":"H Lu","year":"2002","unstructured":"Lu H, Forbes RA, Verma A (2002) Hypoxia-inducible Factor 1 Activation by Aerobic Glycolysis Implicates the Warburg Effect in Carcinogenesis. J Biol Chem 277:23111\u201323115. https:\/\/doi.org\/10.1074\/jbc.M202487200","journal-title":"J Biol Chem"},{"key":"12832_CR14","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1038\/s12276-024-01257-4","volume":"56","author":"M Qiu","year":"2024","unstructured":"Qiu M, Chang L, Tang G et al (2024) Activation of the osteoblastic HIF-1\u03b1 pathway partially alleviates the symptoms of STZ-induced type 1 diabetes mellitus via RegIII\u03b3. Exp Mol Med 56:1574\u20131590. https:\/\/doi.org\/10.1038\/s12276-024-01257-4","journal-title":"Exp Mol Med"},{"key":"12832_CR15","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s00281-019-00757-0","volume":"41","author":"K-H Park-Min","year":"2019","unstructured":"Park-Min K-H (2019) Metabolic reprogramming in osteoclasts. Semin Immunopathol 41:565\u2013572. https:\/\/doi.org\/10.1007\/s00281-019-00757-0","journal-title":"Semin Immunopathol"},{"key":"12832_CR16","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1007\/s11914-023-00825-3","volume":"21","author":"MG Ledesma-Colunga","year":"2023","unstructured":"Ledesma-Colunga MG, Passin V, Lademann F et al (2023) Novel Insights into Osteoclast Energy Metabolism. Curr Osteoporos Rep 21:660\u2013669. https:\/\/doi.org\/10.1007\/s11914-023-00825-3","journal-title":"Curr Osteoporos Rep"},{"key":"12832_CR17","doi-asserted-by":"publisher","first-page":"11058","DOI":"10.1096\/fj.202000771R","volume":"34","author":"B Li","year":"2020","unstructured":"Li B, Lee W, Song C et al (2020) Both aerobic glycolysis and mitochondrial respiration are required for osteoclast differentiation. FASEB J 34:11058\u201311067. https:\/\/doi.org\/10.1096\/fj.202000771R","journal-title":"FASEB J"},{"key":"12832_CR18","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1146\/annurev-biochem-060614-033904","volume":"84","author":"L-Q Chen","year":"2015","unstructured":"Chen L-Q, Cheung LS, Feng L et al (2015) Transport of sugars. Annu Rev Biochem 84:865\u2013894. https:\/\/doi.org\/10.1146\/annurev-biochem-060614-033904","journal-title":"Annu Rev Biochem"},{"key":"12832_CR19","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1136\/ard-2023-224774","volume":"83","author":"K Kachler","year":"2024","unstructured":"Kachler K, Andreev D, Thapa S et al (2024) Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis. Ann Rheum Dis 83:1691\u20131706. https:\/\/doi.org\/10.1136\/ard-2023-224774","journal-title":"Ann Rheum Dis"},{"key":"12832_CR20","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s10020-024-00788-w","volume":"30","author":"H Zheng","year":"2024","unstructured":"Zheng H, Liu Y, Deng Y et al (2024) Recent advances of NFATc1 in rheumatoid arthritis-related bone destruction: mechanisms and potential therapeutic targets. Mol Med 30:20. https:\/\/doi.org\/10.1186\/s10020-024-00788-w","journal-title":"Mol Med"},{"key":"12832_CR21","doi-asserted-by":"publisher","first-page":"22232","DOI":"10.1021\/acsami.4c21489","volume":"17","author":"M Shi","year":"2025","unstructured":"Shi M, Feng J, Chen P et al (2025) Targeted Dual Microdroplets for Modulating Osteoclast Differentiation and Function: A Novel Therapeutic Approach to Combat Osteoporosis. ACS Appl Mater Interfaces 17:22232\u201322244. https:\/\/doi.org\/10.1021\/acsami.4c21489","journal-title":"ACS Appl Mater Interfaces"},{"key":"12832_CR22","doi-asserted-by":"publisher","first-page":"e2423991122","DOI":"10.1073\/pnas.2423991122","volume":"122","author":"X Mo","year":"2025","unstructured":"Mo X, Meng K, Xu B et al (2025) Nat10-mediated N4-acetylcytidine modification enhances Nfatc1 translation to exacerbate osteoclastogenesis in postmenopausal osteoporosis. Proc Natl Acad Sci USA 122:e2423991122. https:\/\/doi.org\/10.1073\/pnas.2423991122","journal-title":"Proc Natl Acad Sci USA"},{"key":"12832_CR23","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s10020-024-00893-w","volume":"30","author":"J Li","year":"2024","unstructured":"Li J, Wei JJ, Wu CH et al (2024) Epimedin A inhibits the PI3K\/AKT\/NF-\u03baB signalling axis and osteoclast differentiation by negatively regulating TRAF6 expression. Mol Med 30:125. https:\/\/doi.org\/10.1186\/s10020-024-00893-w","journal-title":"Mol Med"},{"key":"12832_CR24","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.freeradbiomed.2025.08.057","volume":"240","author":"Y Zhang","year":"2025","unstructured":"Zhang Y, Zhang L, Yang X et al (2025) NFATc1-targeted siRNA microdroplets prevent radiation-induced osteoporosis by coordinating bone-immune crosstalk. Free Radic Biol Med 240:546\u2013558. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2025.08.057","journal-title":"Free Radic Biol Med"},{"key":"12832_CR25","doi-asserted-by":"publisher","first-page":"156276","DOI":"10.1016\/j.phymed.2024.156276","volume":"136","author":"Q Wei","year":"2025","unstructured":"Wei Q, Niu Z-C, Fu X-Y et al (2025) S6K\/FLNC\/ITG\u03b23 signaling pathway regulates osteoclastogenesis and the inhibition of osteoclastogenesis by columbianadin. Phytomedicine 136:156276. https:\/\/doi.org\/10.1016\/j.phymed.2024.156276","journal-title":"Phytomedicine"},{"key":"12832_CR26","doi-asserted-by":"publisher","first-page":"216841","DOI":"10.1016\/j.canlet.2024.216841","volume":"593","author":"L Wang","year":"2024","unstructured":"Wang L, Mao X, Yu X et al (2024) FPR3 reprograms glycolytic metabolism and stemness in gastric cancer via calcium-NFATc1 pathway. Cancer Lett 593:216841. https:\/\/doi.org\/10.1016\/j.canlet.2024.216841","journal-title":"Cancer Lett"},{"key":"12832_CR27","doi-asserted-by":"publisher","first-page":"2856","DOI":"10.7150\/thno.88223","volume":"14","author":"S Madai","year":"2024","unstructured":"Madai S, Kilic P, Schmidt RM et al (2024) Activation of the hypoxia-inducible factor pathway protects against acute ischemic stroke by reprogramming central carbon metabolism. Theranostics 14:2856\u20132880. https:\/\/doi.org\/10.7150\/thno.88223","journal-title":"Theranostics"},{"key":"12832_CR28","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.immuni.2014.09.008","volume":"41","author":"A Palazon","year":"2014","unstructured":"Palazon A, Goldrath A, Nizet V, Johnson RS (2014) HIF Transcription Factors, Inflammation, and Immunity. Immunity 41:518\u2013528. https:\/\/doi.org\/10.1016\/j.immuni.2014.09.008","journal-title":"Immunity"},{"key":"12832_CR29","doi-asserted-by":"publisher","unstructured":"Knowles H (2015) Hypoxic regulation of osteoclast differentiation and bone resorption activity. https:\/\/doi.org\/10.2147\/HP.S95960. HP 73","DOI":"10.2147\/HP.S95960"},{"key":"12832_CR30","doi-asserted-by":"publisher","first-page":"8673","DOI":"10.1073\/pnas.1324290111","volume":"111","author":"JN Regan","year":"2014","unstructured":"Regan JN, Lim J, Shi Y et al (2014) Up-regulation of glycolytic metabolism is required for HIF1\u03b1-driven bone formation. Proc Natl Acad Sci U S A 111:8673\u20138678. https:\/\/doi.org\/10.1073\/pnas.1324290111","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12832_CR31","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1002\/art.42074","volume":"74","author":"K Doi","year":"2022","unstructured":"Doi K, Murata K, Ito S et al (2022) LSD1 metabolically integrates osteoclast differentiation and inflammatory bone resorption through HIF-1\u03b1 and E2F1. Arthritis Rheumatol 74:948\u2013960. https:\/\/doi.org\/10.1002\/art.42074","journal-title":"Arthritis Rheumatol"},{"key":"12832_CR32","doi-asserted-by":"publisher","first-page":"11165","DOI":"10.1002\/jcp.27765","volume":"234","author":"Y Tang","year":"2019","unstructured":"Tang Y, Zhu J, Huang D et al (2019) Mandibular osteotomy-induced hypoxia enhances osteoclast activation and acid secretion by increasing glycolysis. J Cell Physiol 234:11165\u201311175. https:\/\/doi.org\/10.1002\/jcp.27765","journal-title":"J Cell Physiol"},{"key":"12832_CR33","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1158\/1535-7163.MCT-24-0222","volume":"23","author":"X Yang","year":"2024","unstructured":"Yang X, Liu Y, Wang P et al (2024) Targeting PDHK1 by DCA to Restore NK Cell Function in Hepatocellular Carcinoma. Mol Cancer Ther 23:1731\u20131742. https:\/\/doi.org\/10.1158\/1535-7163.MCT-24-0222","journal-title":"Mol Cancer Ther"},{"key":"12832_CR34","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1038\/s41418-024-01315-4","volume":"31","author":"H Wang","year":"2024","unstructured":"Wang H, Sun J, Sun H et al (2024) The OGT-c-Myc-PDK2 axis rewires the TCA cycle and promotes colorectal tumor growth. Cell Death Differ 31:1157\u20131169. https:\/\/doi.org\/10.1038\/s41418-024-01315-4","journal-title":"Cell Death Differ"},{"key":"12832_CR35","doi-asserted-by":"publisher","first-page":"3846","DOI":"10.1074\/jbc.271.7.3846","volume":"271","author":"E Baumgart","year":"1996","unstructured":"Baumgart E, Fahimi HD, Stich A, V\u00f6lkl A (1996) L-lactate dehydrogenase A4- and A3B isoforms are bona fide peroxisomal enzymes in rat liver. Evidence for involvement in intraperoxisomal NADH reoxidation. J Biol Chem 271:3846\u20133855. https:\/\/doi.org\/10.1074\/jbc.271.7.3846","journal-title":"J Biol Chem"},{"key":"12832_CR36","doi-asserted-by":"publisher","first-page":"e0153886","DOI":"10.1371\/journal.pone.0153886","volume":"11","author":"H Ahn","year":"2016","unstructured":"Ahn H, Lee K, Kim JM et al (2016) Accelerated Lactate Dehydrogenase Activity Potentiates Osteoclastogenesis via NFATc1 Signaling. PLoS ONE 11:e0153886. https:\/\/doi.org\/10.1371\/journal.pone.0153886","journal-title":"PLoS ONE"},{"key":"12832_CR37","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1002\/jcb.22640","volume":"110","author":"MJ Oursler","year":"2010","unstructured":"Oursler MJ (2010) Recent Advances In Understanding The Mechanisms Of Osteoclast Precursor Fusion. J Cell Biochem 110:1058\u20131062. https:\/\/doi.org\/10.1002\/jcb.22640","journal-title":"J Cell Biochem"},{"key":"12832_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bioactmat.2025.11.032","volume":"58","author":"Q Wu","year":"2026","unstructured":"Wu Q, Miao J, Chen Y et al (2026) Designed bone-targeting ROS-responsive nanoplatform for precision glycolysis inhibition in postmenopausal osteoporosis. Bioactive Mater 58:1\u201318. https:\/\/doi.org\/10.1016\/j.bioactmat.2025.11.032","journal-title":"Bioactive Mater"},{"key":"12832_CR39","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s00011-019-01228-w","volume":"68","author":"L Wilches-Buitrago","year":"2019","unstructured":"Wilches-Buitrago L, Viacava PR, Cunha FQ et al (2019) Fructose 1,6-bisphosphate inhibits osteoclastogenesis by attenuating RANKL-induced NF-\u03baB\/NFATc-1. Inflamm Res 68:415\u2013421. https:\/\/doi.org\/10.1007\/s00011-019-01228-w","journal-title":"Inflamm Res"},{"key":"12832_CR40","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1159\/000110454","volume":"20","author":"J-M Kim","year":"2007","unstructured":"Kim J-M, Jeong D, Kang HK et al (2007) Osteoclast Precursors Display Dynamic Metabolic Shifts toward Accelerated Glucose Metabolism at an Early Stage of RANKL-Stimulated Osteoclast Differentiation. Cell Physiol Biochem 20:935\u2013946. https:\/\/doi.org\/10.1159\/000110454","journal-title":"Cell Physiol Biochem"},{"key":"12832_CR41","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/s41413-024-00374-0","volume":"12","author":"JC Bertels","year":"2024","unstructured":"Bertels JC, He G, Long F (2024) Metabolic reprogramming in skeletal cell differentiation. Bone Res 12:57. https:\/\/doi.org\/10.1038\/s41413-024-00374-0","journal-title":"Bone Res"},{"key":"12832_CR42","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3389\/fcell.2017.00054","volume":"5","author":"K Tiedemann","year":"2017","unstructured":"Tiedemann K, Le Nihouannen D, Fong JE et al (2017) Regulation of Osteoclast Growth and Fusion by mTOR\/raptor and mTOR\/rictor\/Akt. Front Cell Dev Biol 5:54. https:\/\/doi.org\/10.3389\/fcell.2017.00054","journal-title":"Front Cell Dev Biol"},{"key":"12832_CR43","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1006\/bbrc.1997.6795","volume":"235","author":"JP Williams","year":"1997","unstructured":"Williams JP, Blair HC, McDonald JM et al (1997) Regulation of osteoclastic bone resorption by glucose. Biochem Biophys Res Commun 235:646\u2013651. https:\/\/doi.org\/10.1006\/bbrc.1997.6795","journal-title":"Biochem Biophys Res Commun"},{"key":"12832_CR44","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/jcb.10252","volume":"87","author":"KI Larsen","year":"2002","unstructured":"Larsen KI, Falany ML, Ponomareva LV et al (2002) Glucose-dependent regulation of osteoclast H+ \u2010ATPase expression: Potential role of p38 MAP\u2010kinase. J Cell Biochem 87:75\u201384. https:\/\/doi.org\/10.1002\/jcb.10252","journal-title":"J Cell Biochem"},{"key":"12832_CR45","doi-asserted-by":"publisher","first-page":"C382","DOI":"10.1152\/ajpcell.1996.270.1.C382","volume":"270","author":"BS Lee","year":"1996","unstructured":"Lee BS, Holliday LS, Ojikutu B et al (1996) Osteoclasts express the B2 isoform of vacuolar H(+)-ATPase intracellularly and on their plasma membranes. Am J Physiology-Cell Physiol 270:C382\u2013C388. https:\/\/doi.org\/10.1152\/ajpcell.1996.270.1.C382","journal-title":"Am J Physiology-Cell Physiol"},{"key":"12832_CR46","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.biocel.2016.08.034","volume":"79","author":"S Lemma","year":"2016","unstructured":"Lemma S, Sboarina M, Porporato PE et al (2016) Energy metabolism in osteoclast formation and activity. Int J Biochem Cell Biol 79:168\u2013180. https:\/\/doi.org\/10.1016\/j.biocel.2016.08.034","journal-title":"Int J Biochem Cell Biol"},{"key":"12832_CR47","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/nature13034","volume":"508","author":"JA Spencer","year":"2014","unstructured":"Spencer JA, Ferraro F, Roussakis E et al (2014) Direct measurement of local oxygen concentration in the bone marrow of live animals. Nature 508:269\u2013273. https:\/\/doi.org\/10.1038\/nature13034","journal-title":"Nature"},{"key":"12832_CR48","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1002\/path.4906","volume":"242","author":"PA Hulley","year":"2017","unstructured":"Hulley PA, Bishop T, Vernet A et al (2017) Hypoxia-inducible factor 1\u2010alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl\u20104\u2010hydroxylase 2. J Pathol 242:322\u2013333. https:\/\/doi.org\/10.1002\/path.4906","journal-title":"J Pathol"},{"key":"12832_CR49","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1002\/path.2534","volume":"218","author":"HJ Knowles","year":"2009","unstructured":"Knowles HJ, Athanasou NA (2009) Acute hypoxia and osteoclast activity: a balance between enhanced resorption and increased apoptosis. J Pathol 218:256\u2013264. https:\/\/doi.org\/10.1002\/path.2534","journal-title":"J Pathol"},{"key":"12832_CR50","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1002\/path.4159","volume":"229","author":"KJ Morten","year":"2013","unstructured":"Morten KJ, Badder L, Knowles HJ (2013) Differential regulation of HIF-mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts. J Pathol 229:755\u2013764. https:\/\/doi.org\/10.1002\/path.4159","journal-title":"J Pathol"},{"key":"12832_CR51","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1038\/nrrheum.2011.77","volume":"7","author":"AG Costa","year":"2011","unstructured":"Costa AG, Cusano NE, Silva BC et al (2011) Cathepsin K: its skeletal actions and role as a therapeutic target in osteoporosis. Nat Rev Rheumatol 7:447\u2013456. https:\/\/doi.org\/10.1038\/nrrheum.2011.77","journal-title":"Nat Rev Rheumatol"},{"key":"12832_CR52","doi-asserted-by":"publisher","first-page":"e0138524","DOI":"10.1371\/journal.pone.0138524","volume":"10","author":"J-G Zhang","year":"2015","unstructured":"Zhang J-G, Tan L-J, Xu C et al (2015) Integrative Analysis of Transcriptomic and Epigenomic Data to Reveal Regulation Patterns for BMD Variation. PLoS ONE 10:e0138524. https:\/\/doi.org\/10.1371\/journal.pone.0138524","journal-title":"PLoS ONE"},{"key":"12832_CR53","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1007\/s00198-016-3825-y","volume":"28","author":"W Zhu","year":"2017","unstructured":"Zhu W, Shen H, Zhang J-G et al (2017) Cytosolic proteome profiling of monocytes for male osteoporosis. Osteoporos Int 28:1035\u20131046. https:\/\/doi.org\/10.1007\/s00198-016-3825-y","journal-title":"Osteoporos Int"},{"key":"12832_CR54","doi-asserted-by":"publisher","first-page":"30407","DOI":"10.1074\/jbc.M008768200","volume":"276","author":"M Lu","year":"2001","unstructured":"Lu M, Holliday LS, Zhang L et al (2001) Interaction between Aldolase and Vacuolar H+-ATPase. J Biol Chem 276:30407\u201330413. https:\/\/doi.org\/10.1074\/jbc.M008768200","journal-title":"J Biol Chem"},{"key":"12832_CR55","doi-asserted-by":"publisher","first-page":"19448","DOI":"10.1074\/jbc.M114.569855","volume":"289","author":"C-Y Chan","year":"2014","unstructured":"Chan C-Y, Parra KJ (2014) Yeast Phosphofructokinase-1 Subunit Pfk2p Is Necessary for pH Homeostasis and Glucose-dependent Vacuolar ATPase Reassembly. J Biol Chem 289:19448\u201319457. https:\/\/doi.org\/10.1074\/jbc.M114.569855","journal-title":"J Biol Chem"},{"key":"12832_CR56","doi-asserted-by":"publisher","first-page":"951","DOI":"10.3390\/life11090951","volume":"11","author":"S Gupta","year":"2021","unstructured":"Gupta S, Kadumuri RV, Singh AK et al (2021) Structure, Activity and Function of the Protein Arginine Methyltransferase 6. Life (Basel) 11:951. https:\/\/doi.org\/10.3390\/life11090951","journal-title":"Life (Basel)"},{"key":"12832_CR57","doi-asserted-by":"publisher","first-page":"2403177","DOI":"10.1002\/advs.202403177","volume":"11","author":"W Chu","year":"2024","unstructured":"Chu W, Peng W, Lu Y et al (2024) PRMT6 Epigenetically Drives Metabolic Switch from Fatty Acid Oxidation toward Glycolysis and Promotes Osteoclast Differentiation During Osteoporosis. Adv Sci (Weinh) 11:2403177. https:\/\/doi.org\/10.1002\/advs.202403177","journal-title":"Adv Sci (Weinh)"},{"key":"12832_CR58","doi-asserted-by":"publisher","first-page":"1637232","DOI":"10.3389\/fimmu.2025.1637232","volume":"16","author":"N Wu","year":"2025","unstructured":"Wu N, Wang R, Nian S et al (2025) PRMT6 inhibitors promote fracture healing by modulating osteoclast glucose metabolism. Front Immunol 16:1637232. https:\/\/doi.org\/10.3389\/fimmu.2025.1637232","journal-title":"Front Immunol"},{"key":"12832_CR59","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1038\/s12276-020-00542-2","volume":"52","author":"B Perillo","year":"2020","unstructured":"Perillo B, Tramontano A, Pezone A, Migliaccio A (2020) LSD1: more than demethylation of histone lysine residues. Exp Mol Med 52:1936\u20131947. https:\/\/doi.org\/10.1038\/s12276-020-00542-2","journal-title":"Exp Mol Med"},{"key":"12832_CR60","doi-asserted-by":"publisher","first-page":"3605","DOI":"10.3390\/ijms24043605","volume":"24","author":"M Ding","year":"2023","unstructured":"Ding M, Chen Z, Cho E et al (2023) Crucial Role of Lysine-Specific Histone Demethylase 1 in RANKL-Mediated Osteoclast Differentiation. Int J Mol Sci 24:3605. https:\/\/doi.org\/10.3390\/ijms24043605","journal-title":"Int J Mol Sci"},{"key":"12832_CR61","doi-asserted-by":"publisher","first-page":"101147","DOI":"10.1016\/j.jot.2026.101147","volume":"59","author":"Z He","year":"2026","unstructured":"He Z, Wu Y, You Y et al (2026) Histone H3K18 lactylation: An exercise-induced epigenetic mechanism that inhibits osteoclast activity and protects against osteoporosis. J Orthop Translation 59:101147. https:\/\/doi.org\/10.1016\/j.jot.2026.101147","journal-title":"J Orthop Translation"},{"key":"12832_CR62","doi-asserted-by":"publisher","first-page":"118088","DOI":"10.1016\/j.bcp.2026.118088","volume":"250","author":"Y Ji","year":"2026","unstructured":"Ji Y, Cao T, Rong X et al (2026) Potential modulation of ED-71 in regulating H3K18 histone lactylation to suppress osteoclast differentiation and alleviate postmenopausal osteoporosis. Biochem Pharmacol 250:118088. https:\/\/doi.org\/10.1016\/j.bcp.2026.118088","journal-title":"Biochem Pharmacol"},{"key":"12832_CR63","doi-asserted-by":"publisher","first-page":"111877","DOI":"10.1016\/j.cellsig.2025.111877","volume":"133","author":"X Hu","year":"2025","unstructured":"Hu X, Shen J, Wang R et al (2025) Lactate induces oxidative phosphorylation in osteoblasts via Gpr81\u2013Stat3 signaling. Cell Signal 133:111877. https:\/\/doi.org\/10.1016\/j.cellsig.2025.111877","journal-title":"Cell Signal"},{"key":"12832_CR64","doi-asserted-by":"publisher","first-page":"16004","DOI":"10.1038\/boneres.2016.4","volume":"4","author":"ML Zoch","year":"2016","unstructured":"Zoch ML, Abou DS, Clemens TL et al (2016) In vivo radiometric analysis of glucose uptake and distribution in mouse bone. Bone Res 4:16004. https:\/\/doi.org\/10.1038\/boneres.2016.4","journal-title":"Bone Res"},{"key":"12832_CR65","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1210\/en.2013-1974","volume":"155","author":"AR Guntur","year":"2014","unstructured":"Guntur AR, Le PT, Farber CR, Rosen CJ (2014) Bioenergetics During Calvarial Osteoblast Differentiation Reflect Strain Differences in Bone Mass. Endocrinology 155:1589\u20131595. https:\/\/doi.org\/10.1210\/en.2013-1974","journal-title":"Endocrinology"},{"key":"12832_CR66","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1016\/j.scib.2024.02.036","volume":"69","author":"J Liang","year":"2024","unstructured":"Liang J, Wang J, Sui B et al (2024) Ptip safeguards the epigenetic control of skeletal stem cell quiescence and potency in skeletogenesis. Sci Bull 69:2099\u20132113. https:\/\/doi.org\/10.1016\/j.scib.2024.02.036","journal-title":"Sci Bull"},{"key":"12832_CR67","doi-asserted-by":"publisher","first-page":"101622","DOI":"10.1016\/j.redox.2020.101622","volume":"36","author":"J Maity","year":"2020","unstructured":"Maity J, Deb M, Greene C, Das H (2020) KLF2 regulates dental pulp-derived stem cell differentiation through the induction of mitophagy and altering mitochondrial metabolism. Redox Biol 36:101622. https:\/\/doi.org\/10.1016\/j.redox.2020.101622","journal-title":"Redox Biol"},{"key":"12832_CR68","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/s41574-019-0246-y","volume":"15","author":"N Dirckx","year":"2019","unstructured":"Dirckx N, Moorer MC, Clemens TL, Riddle RC (2019) THE ROLE OF OSTEOBLASTS IN ENERGY HOMEOSTASIS. Nat Rev Endocrinol 15:651\u2013665. https:\/\/doi.org\/10.1038\/s41574-019-0246-y","journal-title":"Nat Rev Endocrinol"},{"key":"12832_CR69","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s11914-014-0235-y","volume":"12","author":"E Esen","year":"2014","unstructured":"Esen E, Long F (2014) Aerobic Glycolysis in Osteoblasts. Curr Osteoporos Rep 12:433\u2013438. https:\/\/doi.org\/10.1007\/s11914-014-0235-y","journal-title":"Curr Osteoporos Rep"},{"key":"12832_CR70","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1210\/er.2017-00064","volume":"38","author":"W-C Lee","year":"2017","unstructured":"Lee W-C, Guntur AR, Long F, Rosen CJ (2017) Energy Metabolism of the Osteoblast: Implications for Osteoporosis. Endocr Rev 38:255\u2013266. https:\/\/doi.org\/10.1210\/er.2017-00064","journal-title":"Endocr Rev"},{"key":"12832_CR71","doi-asserted-by":"publisher","first-page":"14170","DOI":"10.1073\/pnas.1208916109","volume":"109","author":"S Boonrungsiman","year":"2012","unstructured":"Boonrungsiman S, Gentleman E, Carzaniga R et al (2012) The role of intracellular calcium phosphate in osteoblast-mediated bone apatite formation. Proc Natl Acad Sci U S A 109:14170\u201314175. https:\/\/doi.org\/10.1073\/pnas.1208916109","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12832_CR72","doi-asserted-by":"publisher","unstructured":"Costello LC, Franklin RB, Reynolds MA, Chellaiah M (2012) The Important Role of Osteoblasts and Citrate Production in Bone Formation: Osteoblast Citration as a New Concept for an Old Relationship. Open Bone J 4. https:\/\/doi.org\/10.2174\/1876525401204010027. 10.2174\/1876525401204010027","DOI":"10.2174\/1876525401204010027"},{"key":"12832_CR73","doi-asserted-by":"publisher","first-page":"e2212178119","DOI":"10.1073\/pnas.2212178119","volume":"119","author":"N Dirckx","year":"2022","unstructured":"Dirckx N, Zhang Q, Chu EY et al (2022) A specialized metabolic pathway partitions citrate in hydroxyapatite to impact mineralization of bones and teeth. Proc Natl Acad Sci U S A 119:e2212178119. https:\/\/doi.org\/10.1073\/pnas.2212178119","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12832_CR74","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","volume":"169","author":"R Nusse","year":"2017","unstructured":"Nusse R, Clevers H (2017) Wnt\/\u03b2-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. Cell 169:985\u2013999. https:\/\/doi.org\/10.1016\/j.cell.2017.05.016","journal-title":"Cell"},{"key":"12832_CR75","doi-asserted-by":"publisher","first-page":"7810","DOI":"10.1096\/fj.201900201RR","volume":"33","author":"H Chen","year":"2019","unstructured":"Chen H, Ji X, Lee W-C et al (2019) Increased glycolysis mediates Wnt7b-induced bone formation. FASEB j 33:7810\u20137821. https:\/\/doi.org\/10.1096\/fj.201900201RR","journal-title":"FASEB j"},{"key":"12832_CR76","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1016\/j.cell.2015.05.029","volume":"161","author":"J Wei","year":"2015","unstructured":"Wei J, Shimazu J, Makinistoglu MP et al (2015) Glucose uptake and Runx2 synergize to orchestrate osteoblast differentiation and bone formation. Cell 161:1576\u20131591. https:\/\/doi.org\/10.1016\/j.cell.2015.05.029","journal-title":"Cell"},{"key":"12832_CR77","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.cmet.2013.03.017","volume":"17","author":"E Esen","year":"2013","unstructured":"Esen E, Chen J, Karner CM et al (2013) WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation. Cell Metab 17:745\u2013755. https:\/\/doi.org\/10.1016\/j.cmet.2013.03.017","journal-title":"Cell Metab"},{"key":"12832_CR78","doi-asserted-by":"publisher","first-page":"4465","DOI":"10.1038\/s44319-024-00237-z","volume":"25","author":"C You","year":"2024","unstructured":"You C, Shen F, Yang P et al (2024) O-GlcNAcylation mediates Wnt-stimulated bone formation by rewiring aerobic glycolysis. EMBO Rep 25:4465\u20134487. https:\/\/doi.org\/10.1038\/s44319-024-00237-z","journal-title":"EMBO Rep"},{"key":"12832_CR79","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1002\/jbmr.4321","volume":"36","author":"Y Yang","year":"2020","unstructured":"Yang Y, Zhou Y, Xu J et al (2020) Lgr4 promotes aerobic glycolysis and differentiation in osteoblasts via the canonical Wnt\/\u03b2-catenin pathway. J Bone Miner Res 36:1605\u20131620. https:\/\/doi.org\/10.1002\/jbmr.4321","journal-title":"J Bone Miner Res"},{"key":"12832_CR80","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.pharmthera.2015.02.002","volume":"150","author":"RW Johnson","year":"2015","unstructured":"Johnson RW, Schipani E, Giaccia AJ (2015) HIF targets in bone remodeling and metastatic disease. Pharmacol Ther 150:169\u2013177. https:\/\/doi.org\/10.1016\/j.pharmthera.2015.02.002","journal-title":"Pharmacol Ther"},{"key":"12832_CR81","doi-asserted-by":"publisher","unstructured":"Lee S-Y, Long F Notch signaling suppresses glucose metabolism in mesenchymal progenitors to restrict osteoblast differentiation. J Clin Invest 128:5573\u20135586. https:\/\/doi.org\/10.1172\/JCI96221","DOI":"10.1172\/JCI96221"},{"key":"12832_CR82","doi-asserted-by":"publisher","first-page":"3929","DOI":"10.2147\/DDDT.S377001","volume":"16","author":"X Rong","year":"2022","unstructured":"Rong X, Kou Y, Zhang Y et al (2022) ED-71 Prevents Glucocorticoid-Induced Osteoporosis by Regulating Osteoblast Differentiation via Notch and Wnt\/\u03b2-Catenin Pathways. Drug Des Devel Ther 16:3929\u20133946. https:\/\/doi.org\/10.2147\/DDDT.S377001","journal-title":"Drug Des Devel Ther"},{"key":"12832_CR83","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/j.bbrc.2017.11.132","volume":"495","author":"Y-Y Xu","year":"2018","unstructured":"Xu Y-Y, Chen F-L, Ji F et al (2018) Activation of AMP-activated protein kinase by compound 991 protects osteoblasts from dexamethasone. Biochem Biophys Res Commun 495:1014\u20131021. https:\/\/doi.org\/10.1016\/j.bbrc.2017.11.132","journal-title":"Biochem Biophys Res Commun"},{"key":"12832_CR84","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1038\/s41419-019-2112-1","volume":"10","author":"J Liang","year":"2019","unstructured":"Liang J, Zhang X, Zhen Y-F et al (2019) PGK1 depletion activates Nrf2 signaling to protect human osteoblasts from dexamethasone. Cell Death Dis 10:888. https:\/\/doi.org\/10.1038\/s41419-019-2112-1","journal-title":"Cell Death Dis"},{"key":"12832_CR85","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.bbrc.2016.09.027","volume":"479","author":"S-T Li","year":"2016","unstructured":"Li S-T, Chen N-N, Qiao Y-B et al (2016) SC79 rescues osteoblasts from dexamethasone though activating Akt-Nrf2 signaling. Biochem Biophys Res Commun 479:54\u201360. https:\/\/doi.org\/10.1016\/j.bbrc.2016.09.027","journal-title":"Biochem Biophys Res Commun"},{"key":"12832_CR86","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/s41586-018-0622-0","volume":"562","author":"MJ Bollong","year":"2018","unstructured":"Bollong MJ, Lee G, Coukos JS et al (2018) A metabolite-derived protein modification integrates glycolysis with KEAP1\u2013NRF2 signalling. Nature 562:600\u2013604. https:\/\/doi.org\/10.1038\/s41586-018-0622-0","journal-title":"Nature"},{"key":"12832_CR87","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1038\/s41419-021-04250-1","volume":"12","author":"J Liang","year":"2021","unstructured":"Liang J, Zhou Z, Bo L et al (2021) Phosphoglycerate kinase 1 silencing by a novel microRNA microRNA-4523 protects human osteoblasts from dexamethasone through activation of Nrf2 signaling cascade. Cell Death Dis 12:964. https:\/\/doi.org\/10.1038\/s41419-021-04250-1","journal-title":"Cell Death Dis"},{"key":"12832_CR88","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/1476-4598-13-164","volume":"13","author":"M Caspi","year":"2014","unstructured":"Caspi M, Perry G, Skalka N et al (2014) Aldolase positively regulates of the canonical Wnt signaling pathway. Mol Cancer 13:164. https:\/\/doi.org\/10.1186\/1476-4598-13-164","journal-title":"Mol Cancer"},{"key":"12832_CR89","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1359\/jbmr.2001.16.11.1994","volume":"16","author":"J Zhi","year":"2001","unstructured":"Zhi J, Sommerfeldt DW, Rubin CT, Hadjiargyrou M (2001) Differential Expression of Neuroleukin in Osseous Tissues and Its Involvement in Mineralization During Osteoblast Differentiation. J Bone Miner Res 16:1994\u20132004. https:\/\/doi.org\/10.1359\/jbmr.2001.16.11.1994","journal-title":"J Bone Miner Res"},{"key":"12832_CR90","doi-asserted-by":"publisher","first-page":"369","DOI":"10.2106\/JBJS.22.01028","volume":"105","author":"Z Zhu","year":"2023","unstructured":"Zhu Z, Chen Y, Zou J et al (2023) Lactate Mediates the Bone Anabolic Effect of High-Intensity Interval Training by Inducing Osteoblast Differentiation. J Bone Joint Surg 105:369\u2013379. https:\/\/doi.org\/10.2106\/JBJS.22.01028","journal-title":"J Bone Joint Surg"},{"key":"12832_CR91","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.mce.2017.05.017","volume":"452","author":"Y Wu","year":"2017","unstructured":"Wu Y, Wang M, Feng H et al (2017) Lactate induces osteoblast differentiation by stabilization of HIF1\u03b1. Mol Cell Endocrinol 452:84\u201392. https:\/\/doi.org\/10.1016\/j.mce.2017.05.017","journal-title":"Mol Cell Endocrinol"},{"key":"12832_CR92","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/s13075-018-1582-3","volume":"20","author":"S Jo","year":"2018","unstructured":"Jo S, Wang SE, Lee YL et al (2018) IL-17A induces osteoblast differentiation by activating JAK2\/STAT3 in ankylosing spondylitis. Arthritis Res Ther 20:115. https:\/\/doi.org\/10.1186\/s13075-018-1582-3","journal-title":"Arthritis Res Ther"},{"key":"12832_CR93","doi-asserted-by":"publisher","first-page":"29610","DOI":"10.1074\/jbc.M111.226209","volume":"286","author":"K Szczepanek","year":"2011","unstructured":"Szczepanek K, Chen Q, Derecka M et al (2011) Mitochondrial-targeted Signal Transducer and Activator of Transcription 3 (STAT3) Protects against Ischemia-induced Changes in the Electron Transport Chain and the Generation of Reactive Oxygen Species. J Biol Chem 286:29610\u201329620. https:\/\/doi.org\/10.1074\/jbc.M111.226209","journal-title":"J Biol Chem"},{"key":"12832_CR94","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1038\/s42003-025-08957-1","volume":"8","author":"Y Guo","year":"2025","unstructured":"Guo Y, He L, Xue A et al (2025) Exercise increases bone mass by lactate\/Gpr81 signaling pathway. Commun Biol 8:1548. https:\/\/doi.org\/10.1038\/s42003-025-08957-1","journal-title":"Commun Biol"},{"key":"12832_CR95","doi-asserted-by":"publisher","first-page":"10579","DOI":"10.1038\/s41598-018-28605-5","volume":"8","author":"K Sasa","year":"2018","unstructured":"Sasa K, Yoshimura K, Yamada A et al (2018) Monocarboxylate transporter-1 promotes osteoblast differentiation via suppression of p53, a negative regulator of osteoblast differentiation. Sci Rep 8:10579. https:\/\/doi.org\/10.1038\/s41598-018-28605-5","journal-title":"Sci Rep"},{"key":"12832_CR96","doi-asserted-by":"publisher","first-page":"114669","DOI":"10.1016\/j.bcp.2021.114669","volume":"192","author":"T Chen","year":"2021","unstructured":"Chen T, Wang Y, Hao Z et al (2021) Parathyroid hormone and its related peptides in bone metabolism. Biochem Pharmacol 192:114669. https:\/\/doi.org\/10.1016\/j.bcp.2021.114669","journal-title":"Biochem Pharmacol"},{"key":"12832_CR97","doi-asserted-by":"publisher","first-page":"e20780","DOI":"10.1371\/journal.pone.0020780","volume":"6","author":"R Zhang","year":"2011","unstructured":"Zhang R, Edwards JR, Ko S-Y et al (2011) Transcriptional Regulation of BMP2 Expression by the PTH-CREB Signaling Pathway in Osteoblasts. PLoS ONE 6:e20780. https:\/\/doi.org\/10.1371\/journal.pone.0020780","journal-title":"PLoS ONE"},{"key":"12832_CR98","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.bbrc.2018.06.069","volume":"503","author":"Y Wu","year":"2018","unstructured":"Wu Y, Wang M, Zhang K et al (2018) Lactate enhanced the effect of parathyroid hormone on osteoblast differentiation via GPR81-PKC-Akt signaling. Biochem Biophys Res Commun 503:737\u2013743. https:\/\/doi.org\/10.1016\/j.bbrc.2018.06.069","journal-title":"Biochem Biophys Res Commun"},{"key":"12832_CR99","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/nature15377","volume":"526","author":"J Zhou","year":"2015","unstructured":"Zhou J, Wan J, Gao X et al (2015) Dynamic m(6)A mRNA methylation directs translational control of heat shock response. Nature 526:591\u2013594. https:\/\/doi.org\/10.1038\/nature15377","journal-title":"Nature"},{"key":"12832_CR100","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1016\/j.cell.2015.05.014","volume":"161","author":"X Wang","year":"2015","unstructured":"Wang X, Zhao BS, Roundtree IA et al (2015) N6-methyladenosine Modulates Messenger RNA Translation Efficiency. Cell 161:1388\u20131399. https:\/\/doi.org\/10.1016\/j.cell.2015.05.014","journal-title":"Cell"},{"key":"12832_CR101","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nature12730","volume":"505","author":"X Wang","year":"2014","unstructured":"Wang X, Lu Z, Gomez A et al (2014) N6-methyladenosine-dependent regulation of messenger RNA stability. Nature 505:117\u2013120. https:\/\/doi.org\/10.1038\/nature12730","journal-title":"Nature"},{"key":"12832_CR102","doi-asserted-by":"publisher","first-page":"7239","DOI":"10.1093\/nar\/gkab378","volume":"49","author":"S Oerum","year":"2021","unstructured":"Oerum S, Meynier V, Catala M, Tisn\u00e9 C (2021) A comprehensive review of m6A\/m6Am RNA methyltransferase structures. Nucleic Acids Res 49:7239. https:\/\/doi.org\/10.1093\/nar\/gkab378","journal-title":"Nucleic Acids Res"},{"key":"12832_CR103","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/s41419-024-06664-z","volume":"15","author":"R Li","year":"2024","unstructured":"Li R, Zhu C, Wang Y et al (2024) The relationship between the network of non-coding RNAs-molecular targets and N6-methyladenosine modification in tumors of urinary system. Cell Death Dis 15:275. https:\/\/doi.org\/10.1038\/s41419-024-06664-z","journal-title":"Cell Death Dis"},{"key":"12832_CR104","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1177\/00220345211051594","volume":"101","author":"W Cai","year":"2022","unstructured":"Cai W, Ji Y, Han L et al (2022) METTL3-Dependent Glycolysis Regulates Dental Pulp Stem Cell Differentiation. J Dent Res 101:580\u2013589. https:\/\/doi.org\/10.1177\/00220345211051594","journal-title":"J Dent Res"},{"key":"12832_CR105","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1093\/jbmr\/zjae121","volume":"39","author":"W Zhang","year":"2024","unstructured":"Zhang W, Bai Y, Hao L et al (2024) One-carbon metabolism supports S-adenosylmethionine and m6A methylation to control the osteogenesis of bone marrow stem cells and bone formation. J Bone Min Res 39:1356\u20131370. https:\/\/doi.org\/10.1093\/jbmr\/zjae121","journal-title":"J Bone Min Res"},{"key":"12832_CR106","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/s13059-022-02775-y","volume":"23","author":"E Galle","year":"2022","unstructured":"Galle E, Wong C-W, Ghosh A et al (2022) H3K18 lactylation marks tissue-specific active enhancers. Genome Biol 23:207. https:\/\/doi.org\/10.1186\/s13059-022-02775-y","journal-title":"Genome Biol"},{"key":"12832_CR107","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.7150\/ijbs.91492","volume":"20","author":"X Yu","year":"2024","unstructured":"Yu X, Yang J, Xu J et al (2024) Histone lactylation: from tumor lactate metabolism to epigenetic regulation. Int J Biol Sci 20:1833\u20131854. https:\/\/doi.org\/10.7150\/ijbs.91492","journal-title":"Int J Biol Sci"},{"key":"12832_CR108","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-08223-6","author":"Y Liu","year":"2025","unstructured":"Liu Y, Guo X, Hu X et al (2025) Lysine lactylation in diseases: beyond histone lactylation. Cell Death Dis. https:\/\/doi.org\/10.1038\/s41419-025-08223-6","journal-title":"Cell Death Dis"},{"key":"12832_CR109","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1186\/s13287-025-04651-5","volume":"16","author":"H Chen","year":"2025","unstructured":"Chen H, Hua C, Chang S-J et al (2025) H3K18 lactylation-hexokinase 2 positive feedback loop promotes osteogenesis of ASPCs in facial infiltrating lipomatosis. Stem Cell Res Ther 16:538. https:\/\/doi.org\/10.1186\/s13287-025-04651-5","journal-title":"Stem Cell Res Ther"},{"key":"12832_CR110","doi-asserted-by":"publisher","first-page":"11442","DOI":"10.1097\/JS9.0000000000004934","volume":"112","author":"X Xu","year":"2026","unstructured":"Xu X, Xie J, Li E et al (2026) Lactylome-based investigation of osteoarthritic subchondral bone reveals cell-specific differential expression of histone H4K12 lactylation: an experimental study. Int J Surg 112:11442\u201311458. https:\/\/doi.org\/10.1097\/JS9.0000000000004934","journal-title":"Int J Surg"},{"key":"12832_CR111","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s10020-025-01173-x","volume":"31","author":"J Zhou","year":"2025","unstructured":"Zhou J, Wang R, Zhang Z, Xue Y (2025) METTL3 regulated by histone lactylation promotes ossification of the ligamentum flavum by enhancing the m6A methylation of BMP2. Mol Med 31:118. https:\/\/doi.org\/10.1186\/s10020-025-01173-x","journal-title":"Mol Med"},{"key":"12832_CR112","doi-asserted-by":"publisher","first-page":"e71765","DOI":"10.1096\/fj.202502919RR","volume":"40","author":"X Yu","year":"2026","unstructured":"Yu X, Zhu M, Luo X et al (2026) Lactate-Driven Epigenetic Reprogramming of Osteogenesis: H3K18 Lactylation Activates m6A \/ YTHDF1 \u2010Dependent YAP1 Signaling to Combat Bone Loss. FASEB J 40:e71765. https:\/\/doi.org\/10.1096\/fj.202502919RR","journal-title":"FASEB J"},{"key":"12832_CR113","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/S1875-5364(25)60864-8","volume":"23","author":"Y Jin","year":"2025","unstructured":"Jin Y, Wang Y, Wang C et al (2025) Salidroside inhibits osteoclast differentiation based on osteoblast-osteoclast interaction via HIF-1\u03b1 pathway. Chin J Nat Med 23:572\u2013584. https:\/\/doi.org\/10.1016\/S1875-5364(25)60864-8","journal-title":"Chin J Nat Med"},{"key":"12832_CR114","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1080\/13543776.2024.2327300","volume":"34","author":"M Viviano","year":"2024","unstructured":"Viviano M, Cipriano A, Fabbrizi E et al (2024) Successes and challenges in the development of BD1-selective BET inhibitors: a patent review. Expert Opin Ther Pat 34:529\u2013545. https:\/\/doi.org\/10.1080\/13543776.2024.2327300","journal-title":"Expert Opin Ther Pat"},{"key":"12832_CR115","doi-asserted-by":"publisher","first-page":"10464","DOI":"10.1021\/acs.jmedchem.4c00959","volume":"67","author":"DJ Hirst","year":"2024","unstructured":"Hirst DJ, Bamborough P, Al-Mahdi N et al (2024) Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787. J Med Chem 67:10464\u201310489. https:\/\/doi.org\/10.1021\/acs.jmedchem.4c00959","journal-title":"J Med Chem"},{"key":"12832_CR116","doi-asserted-by":"publisher","first-page":"5184","DOI":"10.1021\/acs.jmedchem.1c01835","volume":"65","author":"J Chen","year":"2022","unstructured":"Chen J, Tang P, Wang Y et al (2022) Targeting Bromodomain-Selective Inhibitors of BET Proteins in Drug Discovery and Development. J Med Chem 65:5184\u20135211. https:\/\/doi.org\/10.1021\/acs.jmedchem.1c01835","journal-title":"J Med Chem"},{"key":"12832_CR117","doi-asserted-by":"publisher","first-page":"e70496","DOI":"10.1002\/ctm2.70496","volume":"15","author":"X Wang","year":"2025","unstructured":"Wang X, Luo F, Miao G et al (2025) Loss of Brd4 alleviates pathological bone loss via Slc9b2 suppression in osteoclastogenesis. Clin Transl Med 15:e70496. https:\/\/doi.org\/10.1002\/ctm2.70496","journal-title":"Clin Transl Med"},{"key":"12832_CR118","doi-asserted-by":"publisher","first-page":"119118","DOI":"10.1016\/j.ejmech.2026.119118","volume":"317","author":"J-Y Xie","year":"2026","unstructured":"Xie J-Y, Pang Y-W, Yu C-L et al (2026) Advances in selective inhibitors targeting the BD1 and BD2 domains of BET proteins. Eur J Med Chem 317:119118. https:\/\/doi.org\/10.1016\/j.ejmech.2026.119118","journal-title":"Eur J Med Chem"},{"key":"12832_CR119","doi-asserted-by":"publisher","first-page":"116440","DOI":"10.1016\/j.intimp.2026.116440","volume":"176","author":"H Chang","year":"2026","unstructured":"Chang H, Li Y, Wang Z et al (2026) Isoliquiritigenin restores bone homeostasis in osteoporotic rats by enhancing BMSCs osteogenesis via ERK1\/2-mTOR-HIF-1\u03b1-glycolytic axis and suppressing inflammation. Int Immunopharmacol 176:116440. https:\/\/doi.org\/10.1016\/j.intimp.2026.116440","journal-title":"Int Immunopharmacol"},{"key":"12832_CR120","doi-asserted-by":"publisher","first-page":"117447","DOI":"10.1016\/j.biopha.2024.117447","volume":"180","author":"J Ma","year":"2024","unstructured":"Ma J, Li X, Li Q et al (2024) Niacin regulates glucose metabolism and osteogenic differentiation via the SIRT2-C\/EBP\u03b2-AREG signaling axis. Biomed Pharmacother 180:117447. https:\/\/doi.org\/10.1016\/j.biopha.2024.117447","journal-title":"Biomed Pharmacother"},{"key":"12832_CR121","doi-asserted-by":"publisher","first-page":"113406","DOI":"10.1016\/j.celrep.2023.113406","volume":"42","author":"S Zhu","year":"2023","unstructured":"Zhu S, Yuan Q, Li X et al (2023) Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2. Cell Rep 42:113406. https:\/\/doi.org\/10.1016\/j.celrep.2023.113406","journal-title":"Cell Rep"},{"key":"12832_CR122","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1007\/s13311-023-01376-2","volume":"20","author":"E Wuerch","year":"2023","unstructured":"Wuerch E, Urgoiti GR, Yong VW (2023) The Promise of Niacin in Neurology. Neurotherapeutics 20:1037\u20131054. https:\/\/doi.org\/10.1007\/s13311-023-01376-2","journal-title":"Neurotherapeutics"},{"key":"12832_CR123","doi-asserted-by":"publisher","first-page":"153605","DOI":"10.1016\/j.phymed.2021.153605","volume":"88","author":"KKL Kwan","year":"2021","unstructured":"Kwan KKL, Dong TTX, Tsim KWK (2021) Danggui Buxue Tang, a Chinese herbal decoction containing Astragali Radix and Angelicae Sinensis Radix, improves mitochrondial bioenergetics in osteoblast. Phytomedicine 88:153605. https:\/\/doi.org\/10.1016\/j.phymed.2021.153605","journal-title":"Phytomedicine"},{"key":"12832_CR124","doi-asserted-by":"publisher","first-page":"e1369","DOI":"10.1002\/ctm2.1369","volume":"13","author":"L Zhang","year":"2023","unstructured":"Zhang L, Jiao G, You Y et al (2023) Arginine methylation of PPP1CA by CARM1 regulates glucose metabolism and affects osteogenic differentiation and osteoclastic differentiation. Clin Translational Med 13:e1369. https:\/\/doi.org\/10.1002\/ctm2.1369","journal-title":"Clin Translational Med"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12832-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12832-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12832-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:02:03Z","timestamp":1790550123000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11033-026-12832-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,27]]},"references-count":124,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12832"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12832-5","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,27]]},"assertion":[{"value":"16 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1645"}}