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This study is a narrative review and did not involve human participants or animal subjects.","order":2,"name":"Ethics","label":"Institutional review board statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Informed consent statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The initial draft of this manuscript was written independently by the authors. ChatGPT (OpenAI) was used solely to translate and polish the English language of the author-written draft, limited to improving grammar, wording, and readability. All text generated by the tool was reviewed and revised sentence by sentence by the authors. All academic viewpoints, study design, data analysis, and conclusions are the sole responsibility of the authors. No AI-assisted tool was used to generate oranalyze study data. The tool was not involved in appraising the literature search results; all references were verified by the authors against the original sources.","order":4,"name":"Ethics","label":"Declaration of generative AI and AI-assisted technologies in the writing process","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"PubMed\/MEDLINE and Crossref were searched from database inception through 10 June 2026. Search terms included combinations of \u201cchronic kidney disease\u201d or \u201crenal fibrosis\u201d with \u201crenal tubular epithelial cell\u201d, \u201cproximal tubule\u201d, \u201cmitochondria\u201d, \u201cfatty acid oxidation\u201d, \u201coxidative phosphorylation\u201d, \u201cNAD\u207a\u201d, \u201cmitophagy\u201d, \u201cmitochondrial dynamics\u201d, \u201cmitochondria-associated membrane\u201d, \u201cmtDNA\u201d, \u201cinflammasome\u201d, \u201csingle-cell\u201d, \u201cspatial transcriptomics\u201d, \u201corganoid\u201d, \u201cbiomarker\u201d, or intervention-specific terms. English-language original studies, human biopsy and clinical studies, multi-omic datasets, and authoritative reviews were considered, with a focus on literature published during 2021\u20132026. Reference lists were hand-searched, and supplementary targeted searches conducted during manuscript development identified additional studies that substantially informed the synthesis. As a narrative review, study selection and evidence synthesis were qualitative; no formal risk-of-bias assessment or meta-analysis was performed.","order":5,"name":"Ethics","label":"Literature search strategy","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1675"}}