{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:18:40Z","timestamp":1792783120571,"version":"4.5.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Bolashak Center for International Programs in Kazakhstan","award":["contract from \u00ab29\u00bb January 2025, \u21160162\/01\/25"],"award-info":[{"award-number":["contract from \u00ab29\u00bb January 2025, \u21160162\/01\/25"]}]},{"name":"Medical Research Council","award":["MC_PC_17192"],"award-info":[{"award-number":["MC_PC_17192"]}]},{"name":"Royal Society","award":["Project reference: RG160449"],"award-info":[{"award-number":["Project reference: RG160449"]}],"id":[{"id":"https:\/\/ror.org\/03wnrjx87","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Renal fibrosis is a major morphological feature of chronic kidney disease and is considered an important pathogenetic process that leads to a decline in renal function in the progressive course of the disease. It is characterized by excessive accumulation of extracellular matrix, tubular atrophy, interstitial inflammation, capillary thinning, and nephron structural disruption. The development of fibrosis involves transforming growth factor-\u03b2 (TGF-\u03b2), Wnt\/\u03b2-catenin, inflammatory mediators, and intercellular communication between macrophages and activated fibroblasts. TGF-\u03b2, as one of the main driving factors of renal fibrosis, enhancing the activation of myofibroblasts and the accumulation of extracellular matrix proteins such as collagen and fibronectin through Smad-dependent and Smad-independent pathways. Collagen Triple Helix Repeat Containing 1 (CTHRC1), a secreted glycoprotein, was initially described in vascular remodeling and tissue repair processes after injury, and later studies began to consider it as a regulatory molecule in fibrotic diseases. The high expression of CTHRC1 protein in renal tissue in tubular cells and undetectable levels in glomerular cells provide a basis for investigating its association with tubulointerstitial injury in the kidney. CTHRC1 may be involved in fibroblast migration, tissue remodeling, extracellular matrix metabolism, and interaction with the TGF-\u03b2\/Wnt signaling systems during kidney fibrogenesis. This review discusses the potential role of CTHRC1 in renal fibrosis, its relationship with the TGF-\u03b2 and Wnt\/\u03b2-catenin pathways, and its potential as a diagnostic biomarker and therapeutic target in chronic kidney diseases.<\/jats:p>","DOI":"10.1007\/s11033-026-12886-5","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:22:34Z","timestamp":1792160554000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potential role of CTHRC1 in renal fibrosis"],"prefix":"10.1007","volume":"53","author":[{"given":"Gulzhan","family":"Bolebay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raushan","family":"Ayekenova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roza","family":"Izimova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balzat","family":"Sarimbayeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galym A.","family":"Shegenov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assem Kaliyeva","family":"Mukhtarkhanovna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arman","family":"Issimov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Askhat","family":"Myngbay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikki A.","family":"Copeland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makhabbat","family":"Amanbayeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Hardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"issue":"1","key":"12886_CR1","doi-asserted-by":"publisher","first-page":"9578701","DOI":"10.1155\/2020\/9578701","volume":"2020","author":"D Mei","year":"2020","unstructured":"Mei D, Zhu Y, Zhang L, Wei W (2020) The Role of CTHRC1 in Regulation of Multiple Signaling and Tumor Progression and Metastasis. Mediators Inflamm 2020(1):9578701. https:\/\/doi.org\/10.1155\/2020\/9578701","journal-title":"Mediators Inflamm"},{"key":"12886_CR2","doi-asserted-by":"publisher","unstructured":"Qin S, Zheng Jhong, Xia Z, huan, Qian J, Deng C, liang, Yang S (2019) lin. CTHRC1 promotes wound repair by increasing M2 macrophages via regulating the TGF-\u03b2 and notch pathways. Biomed Pharmacother. ;113:108594. https:\/\/doi.org\/10.1016\/j.biopha.2019.01.055","DOI":"10.1016\/j.biopha.2019.01.055"},{"key":"12886_CR3","doi-asserted-by":"publisher","unstructured":"Myngbay A, Manarbek L, Ludbrook S, Kunz J (2021) The Role of Collagen Triple Helix Repeat-Containing 1 Protein (CTHRC1) in Rheumatoid Arthritis. Int J Mol Sci 22(5). https:\/\/doi.org\/10.3390\/ijms22052426","DOI":"10.3390\/ijms22052426"},{"issue":"4","key":"12886_CR4","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.7150\/ijbs.79260","volume":"19","author":"D Wang","year":"2023","unstructured":"Wang D, Zhang Y, Ye T, Zhang R, Zhang L, Shi D et al (2023) Cthrc1 deficiency aggravates wound healing and promotes cardiac rupture after myocardial infarction via non-canonical WNT5A signaling pathway. Int J Biol Sci 19(4):1299\u20131315. https:\/\/doi.org\/10.7150\/ijbs.79260","journal-title":"Int J Biol Sci"},{"issue":"11","key":"12886_CR5","doi-asserted-by":"publisher","first-page":"3033","DOI":"10.3390\/biomedicines11113033","volume":"11","author":"S Altamura","year":"2023","unstructured":"Altamura S, Pietropaoli D, Lombardi F, Del Pinto R, Ferri C (2023) An Overview of Chronic Kidney Disease Pathophysiology: The Impact of Gut Dysbiosis and Oral Disease. Biomedicines 11(11):3033. https:\/\/doi.org\/10.3390\/biomedicines11113033 PubMed PMID: 38002033; PubMed Central PMCID: PMC10669155","journal-title":"Biomedicines"},{"key":"12886_CR6","doi-asserted-by":"publisher","unstructured":"Alamilla-Sanchez M, Salgado MAA, Galv\u00e1n VMU, Salguero VY, Estrella MBY, L\u00f3pez EFM et al (2025) Understanding Renal Tubular Function: Key Mechanisms, Clinical Relevance, and Comprehensive Urine Assessment. Pathophysiology 32(3). https:\/\/doi.org\/10.3390\/pathophysiology32030033","DOI":"10.3390\/pathophysiology32030033"},{"key":"12886_CR7","doi-asserted-by":"publisher","unstructured":"Baiken Y, Markhametova Z, Ashimova A, Zhulamanova A, Nogaibayeva A, Kozina L et al (2023) Elevated Levels of Plasma Collagen Triple Helix Repeat Containing 1 (CTHRC1) Are Strongly Associated with eGFR and Albuminuria in Chronic Kidney Disease. Med (Mex) 59(4). https:\/\/doi.org\/10.3390\/medicina59040651","DOI":"10.3390\/medicina59040651"},{"key":"12886_CR8","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.ebiom.2019.01.009","volume":"40","author":"J Li","year":"2019","unstructured":"Li J, Wang Y, Ma M, Jiang S, Zhang X, Zhang Y et al (2019) Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-\u03b2 signaling. EBioMedicine 40:43\u201355. https:\/\/doi.org\/10.1016\/j.ebiom.2019.01.009 PubMed PMID: 30639416; PubMed Central PMCID: PMC6412555","journal-title":"EBioMedicine"},{"issue":"1","key":"12886_CR9","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1038\/s41467-020-15647-5","volume":"11","author":"T Tsukui","year":"2020","unstructured":"Tsukui T, Sun KH, Wetter JB, Wilson-Kanamori JR, Hazelwood LA, Henderson NC et al (2020) Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis. Nat Commun 11(1):1920. https:\/\/doi.org\/10.1038\/s41467-020-15647-5","journal-title":"Nat Commun"},{"issue":"19","key":"12886_CR10","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1161\/CIRCULATIONAHA.119.044557","volume":"142","author":"A Ruiz-Villalba","year":"2020","unstructured":"Ruiz-Villalba A, Romero JP, Hern\u00e1ndez SC, Vilas-Zornoza A, Fortelny N, Castro-Labrador L et al (2020) Single-Cell RNA Sequencing Analysis Reveals a Crucial Role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) Cardiac Fibroblasts After Myocardial Infarction. Circulation 142(19):1831\u20131847 .044557 PubMed PMID: 32972203; PubMed Central PMCID: PMC7730974","journal-title":"Circulation"},{"issue":"9","key":"12886_CR11","doi-asserted-by":"publisher","first-page":"801","DOI":"10.21037\/atm-21-1884","volume":"9","author":"Z Shen","year":"2021","unstructured":"Shen Z, Su T, Chen J, Xie Z, Li J (2021) Collagen triple helix repeat containing-1 exerts antifibrotic effects on human skin fibroblast and bleomycin-induced dermal fibrosis models. Ann Transl Med 9(9):801. https:\/\/doi.org\/10.21037\/atm-21-1884 PubMed PMID: 34268414; PubMed Central PMCID: PMC8246160","journal-title":"Ann Transl Med"},{"issue":"12","key":"12886_CR12","doi-asserted-by":"publisher","first-page":"e1115","DOI":"10.1002\/ctm2.1115","volume":"12","author":"J Liu","year":"2022","unstructured":"Liu J, Huang Y, Gong Y, Liu Q, Lin J, Liu J et al (2022) CTHRC1\u2009+\u2009fibroblasts are stimulated by macrophage-secreted SPP1 to induce excessive collagen deposition in keloids. Clin Transl Med 12(12):e1115. https:\/\/doi.org\/10.1002\/ctm2.1115","journal-title":"Clin Transl Med"},{"issue":"3","key":"12886_CR13","doi-asserted-by":"publisher","first-page":"102934","DOI":"10.1016\/j.jbc.2023.102934","volume":"299","author":"T Hironaka","year":"2023","unstructured":"Hironaka T, Takizawa N, Yamauchi Y, Horii Y, Nakaya M (2023) The well-developed actin cytoskeleton and Cthrc1 expression by actin-binding protein drebrin in myofibroblasts promote cardiac and hepatic fibrosis. J Biol Chem 299(3):102934. https:\/\/doi.org\/10.1016\/j.jbc.2023.102934 PubMed PMID: 36690273; PubMed Central PMCID: PMC9988570","journal-title":"J Biol Chem"},{"issue":"23","key":"12886_CR14","doi-asserted-by":"publisher","first-page":"6536","DOI":"10.1016\/j.cell","volume":"188","author":"KE Bauer-Rowe","year":"2025","unstructured":"Bauer-Rowe KE, Pham B, Griffin M, Liang NE, Kim A, Lu JM et al (2025) Creeping fat-derived mechanosensitive fibroblasts drive intestinal fibrosis in Crohn\u2019s disease strictures. Cell 188(23):6536\u20136553e26. https:\/\/doi.org\/10.1016\/j.cell.2025.08.029 PubMed PMID: 40967215","journal-title":"Cell"},{"key":"12886_CR15","doi-asserted-by":"publisher","DOI":"10.64898\/2026.04.08.717092","author":"ND Vanegas-Avendano","year":"2026","unstructured":"Vanegas-Avendano ND, Chen H, Wellmerling J, Rodriguez-Lopez J, Ghobashi A, Peters V et al (2026) Transcriptional and spatial profiling of fibroblasts from human lungs highlights CTHRC1\u2009+\u2009cells as fibrogenic signaling hubs in fibrosis. bioRxiv: Preprint Serv Biology. https:\/\/doi.org\/10.64898\/2026.04.08.717092 PubMed PMID: 41993306; PubMed Central PMCID: PMC13081991","journal-title":"bioRxiv: Preprint Serv Biology"},{"issue":"7","key":"12886_CR16","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1161\/ATVBAHA.108.166579","volume":"28","author":"RJ Leclair","year":"2008","unstructured":"Leclair RJ, Wang Q, Benson MA, Prudovsky I, Lindner V (2008) Intracellular localization of Cthrc1 characterizes differentiated smooth muscle. Arterioscler Thromb Vasc Biol 28(7):1332\u20131338. https:\/\/doi.org\/10.1161\/ATVBAHA.108.166579 PubMed PMID: 18467647; PubMed Central PMCID: PMC3508505","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"12886_CR17","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1161\/01.RES.0000154262.07264","volume":"96","author":"P Pyagay","year":"2005","unstructured":"Pyagay P, Heroult M, Wang Q, Lehnert W, Belden J, Liaw L et al (2005) Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration. Circ Res 96(2):261\u2013268. https:\/\/doi.org\/10.1161\/01.RES.0000154262.07264.12 PubMed PMID: 15618538","journal-title":"Circ Res"},{"issue":"6","key":"12886_CR18","doi-asserted-by":"publisher","first-page":"266","DOI":"10.3892\/ol.2023.13852","volume":"25","author":"YJ Liu","year":"2023","unstructured":"Liu YJ, Du J, Li J, Tan XP, Zhang Q (2023) CTHRC1, a novel gene with multiple functions in physiology, disease and solid tumors (Review). Oncol Lett 25(6):266. https:\/\/doi.org\/10.3892\/ol.2023.13852 PubMed PMID: 37216164; PubMed Central PMCID: PMC10193374","journal-title":"Oncol Lett"},{"issue":"9","key":"12886_CR19","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.3390\/biom15091273","volume":"15","author":"Q Deng","year":"2025","unstructured":"Deng Q, Wu L, Zhang C, Dang M (2025) Global Fibrosis Burden and a Transcriptional Biomarker-Based Strategy for Early Detection in Resource-Limited Settings. Biomolecules 15(9):1273. https:\/\/doi.org\/10.3390\/biom15091273 PubMed PMID: 41008580; PubMed Central PMCID: PMC12467191","journal-title":"Biomolecules"},{"key":"12886_CR20","doi-asserted-by":"publisher","unstructured":"Rosenbloom J, Mendoza FA, Jimenez SA Strategies for anti-fibrotic therapies. Biochim Biophys Acta BBA - Mol Basis Dis. 2013;Fibrosis: Translation of basic research to human disease1832(7):1088\u20131103. https:\/\/doi.org\/10.1016\/j.bbadis.2012.12.007","DOI":"10.1016\/j.bbadis.2012.12.007"},{"issue":"3","key":"12886_CR21","doi-asserted-by":"publisher","first-page":"e20190103","DOI":"10.1084\/jem","volume":"217","author":"NG Frangogiannis","year":"2020","unstructured":"Frangogiannis NG (2020) Transforming growth factor\u2013\u03b2 in tissue fibrosis. J Exp Med 217(3):e20190103. https:\/\/doi.org\/10.1084\/jem.20190103 PubMed PMID: 32997468; PubMed Central PMCID: PMC7062524","journal-title":"J Exp Med"},{"issue":"1","key":"12886_CR22","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/s41392-024-01764-w","volume":"9","author":"Z Deng","year":"2024","unstructured":"Deng Z, Fan T, Xiao C, Tian H, Zheng Y, Li C et al (2024) TGF-\u03b2 signaling in health, disease and therapeutics. Signal Transduct Target Ther 9(1):61. https:\/\/doi.org\/10.1038\/s41392-024-01764-w","journal-title":"Signal Transduct Target Ther"},{"key":"12886_CR23","doi-asserted-by":"crossref","unstructured":"Herrera J, Henke CA, Bitterman PB Extracellular matrix as a driver of progressive fibrosis. J Clin Invest 128(1):45\u201353. doi:10.1172\/JCI93557 PubMed PMID: 29293088; PubMed Central PMCID: PMC5749528.","DOI":"10.1172\/JCI93557"},{"issue":"1","key":"12886_CR24","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1186\/s12891-016-1326-y","volume":"17","author":"C Zhou","year":"2016","unstructured":"Zhou C, Liu F, Gallo PH, Baratz ME, Kathju S, Satish L (2016) Anti-fibrotic action of pirfenidone in Dupuytren\u2019s disease-derived fibroblasts. BMC Musculoskelet Disord 17(1):469. https:\/\/doi.org\/10.1186\/s12891-016-1326-y","journal-title":"BMC Musculoskelet Disord"},{"key":"12886_CR25","doi-asserted-by":"publisher","first-page":"112154","DOI":"10.1016\/j.ejmech.2020.112154","volume":"191","author":"H Wang","year":"2020","unstructured":"Wang H, Chen M, Sang X, You X, Wang Y, Paterson IC et al (2020) Development of small molecule inhibitors targeting TGF-\u03b2 ligand and receptor: Structures, mechanism, preclinical studies and clinical usage. Eur J Med Chem 191:112154. https:\/\/doi.org\/10.1016\/j.ejmech.2020.112154","journal-title":"Eur J Med Chem"},{"issue":"6","key":"12886_CR26","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1161\/01.RES.0000260806.99307.72","volume":"100","author":"RJ LeClair","year":"2007","unstructured":"LeClair RJ, Durmus T, Wang Q, Pyagay P, Terzic A, Lindner V (2007) Cthrc1 Is a Novel Inhibitor of Transforming Growth Factor-\u03b2 Signaling and Neointimal Lesion Formation. Circ Res 100(6):826\u2013833. https:\/\/doi.org\/10.1161\/01.RES.0000260806.99307.72","journal-title":"Circ Res"},{"key":"12886_CR27","doi-asserted-by":"publisher","first-page":"379","DOI":"10.2741\/4214","volume":"19","author":"Y Wang","year":"2014","unstructured":"Wang Y, Li YP, Paulson C, Shao JZ, Zhang X, Wu M et al (2014) Wnt and the Wnt signaling pathway in bone development and disease. Front Biosci Landmark Ed 19:379\u2013407 doi:10.2741\/4214 PubMed PMID: 24389191; PubMed Central PMCID: PMC4000238","journal-title":"Front Biosci Landmark Ed"},{"key":"12886_CR28","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/s41392-025-02142","volume":"10","author":"C Xue","year":"2025","unstructured":"Xue C, Chu Q, Shi Q, Zeng Y, Lu J, Li L (2025) Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances. Signal Transduct Target Ther 10:106. https:\/\/doi.org\/10.1038\/s41392-025-02142-w PubMed PMID: 40180907; PubMed Central PMCID: PMC11968978","journal-title":"Signal Transduct Target Ther"},{"issue":"11","key":"12886_CR29","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1007\/s00109-020-01978-9","volume":"98","author":"P Meng","year":"2020","unstructured":"Meng P, Zhu M, Ling X, Zhou L (2020) Wnt signaling in kidney: the initiator or terminator? J Mol Med Berl Ger 98(11):1511\u20131523. https:\/\/doi.org\/10.1007\/s00109-020-01978-9 PubMed PMID: 32939578; PubMed Central PMCID: PMC7591426","journal-title":"J Mol Med Berl Ger"},{"key":"12886_CR30","doi-asserted-by":"publisher","unstructured":"Pond KW, Doubrovinski K, Thorne CA (2020) Wnt\/\u03b2-catenin Signaling in Tissue Self-Organization. Genes 11(8). https:\/\/doi.org\/10.3390\/genes11080939","DOI":"10.3390\/genes11080939"},{"issue":"1","key":"12886_CR31","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.devcel.2008.05.007","volume":"15","author":"S Yamamoto","year":"2008","unstructured":"Yamamoto S, Nishimura O, Misaki K, Nishita M, Minami Y, Yonemura S et al (2008) Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev Cell 15(1):23\u201336. https:\/\/doi.org\/10.1016\/j.devcel.2008.05.007 PubMed PMID: 18606138","journal-title":"Dev Cell"},{"issue":"2","key":"12886_CR32","doi-asserted-by":"publisher","first-page":"3957","DOI":"10.1093\/gbe\/evaa020","volume":"12","author":"L Lecl\u00e8re","year":"2020","unstructured":"Lecl\u00e8re L, Nir TS, Bazarsky M, Braitbard M, Schneidman-Duhovny D, Gat U (2020) Dynamic Evolution of the Cthrc1 Genes, a Newly Defined Collagen-Like Family. Genome Biol Evol 12(2):3957\u20133970. https:\/\/doi.org\/10.1093\/gbe\/evaa020","journal-title":"Genome Biol Evol"},{"issue":"11","key":"12886_CR33","doi-asserted-by":"publisher","first-page":"946","DOI":"10.3390\/cells13110946","volume":"13","author":"Z Mukhatayev","year":"2024","unstructured":"Mukhatayev Z, Adilbayeva A, Kunz J (2024) CTHRC1: An Emerging Hallmark of Pathogenic Fibroblasts in Lung Fibrosis. Cells 13(11):946 doi:10.3390\/cells13110946 PubMed PMID: 38891078; PubMed Central PMCID: PMC11171484","journal-title":"Cells"},{"key":"12886_CR34","doi-asserted-by":"publisher","first-page":"797292","DOI":"10.3389\/fphar","volume":"12","author":"Q Mei","year":"2022","unstructured":"Mei Q, Liu Z, Zuo H, Yang Z, Qu J (2022) Idiopathic Pulmonary Fibrosis: An Update on Pathogenesis. Front Pharmacol 12:797292. https:\/\/doi.org\/10.3389\/fphar2021.797292 PubMed PMID: 35126134; PubMed Central PMCID: PMC8807692","journal-title":"Front Pharmacol"},{"issue":"5","key":"12886_CR35","doi-asserted-by":"publisher","first-page":"e13115","DOI":"10.14814\/phy2","volume":"5","author":"AP Binks","year":"2017","unstructured":"Binks AP, Beyer M, Miller R, LeClair RJ (2017) Cthrc1 lowers pulmonary collagen associated with bleomycin-induced fibrosis and protects lung function. Physiol Rep 5(5):e13115. https:\/\/doi.org\/10.14814\/phy213115 PubMed PMID: 28292882; PubMed Central PMCID: PMC5350163","journal-title":"Physiol Rep"},{"issue":"8021","key":"12886_CR36","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/s41586-024-07660-1","volume":"631","author":"T Tsukui","year":"2024","unstructured":"Tsukui T, Wolters PJ, Sheppard D (2024) Alveolar fibroblast lineage orchestrates lung inflammation and fibrosis. Nature 631(8021):627\u2013634. https:\/\/doi.org\/10.1038\/s41586-024-07660-1 PubMed PMID: 38987592; PubMed Central PMCID: PMC12088911","journal-title":"Nature"},{"issue":"19","key":"12886_CR37","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1161\/CIRCULATIONAHA.119.044557","volume":"142","author":"A Ruiz-Villalba","year":"2020","unstructured":"Ruiz-Villalba A, Romero JP, Hern\u00e1ndez SC, Vilas-Zornoza A, Fortelny N, Castro-Labrador L et al (2020) Single-Cell RNA Sequencing Analysis Reveals a Crucial Role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) Cardiac Fibroblasts After Myocardial Infarction. Circulation 142(19):1831\u20131847 .044557 PubMed PMID: 32972203; PubMed Central PMCID: PMC7730974","journal-title":"Circulation"},{"issue":"11","key":"12886_CR38","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.3390\/cells8111419","volume":"8","author":"B Dewidar","year":"2019","unstructured":"Dewidar B, Meyer C, Dooley S, Meindl-Beinker N (2019) TGF-\u03b2 in Hepatic Stellate Cell Activation and Liver Fibrogenesis\u2014Updated 2019. Cells 8(11):1419 doi:10.3390\/cells8111419 PubMed PMID: 31718044; PubMed Central PMCID: PMC6912224","journal-title":"Cells"},{"key":"12886_CR39","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.ebiom.2019.01.009","volume":"40","author":"J Li","year":"2019","unstructured":"Li J, Wang Y, Ma M, Jiang S, Zhang X, Zhang Y et al (2019) Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-\u03b2 signaling. EBioMedicine 40:43\u201355. https:\/\/doi.org\/10.1016\/j.ebiom.2019.01.009 PubMed PMID: 30639416; PubMed Central PMCID: PMC6412555","journal-title":"EBioMedicine"},{"key":"12886_CR40","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jaut.2015.07.010","volume":"63","author":"Z Bian","year":"2015","unstructured":"Bian Z, Miao Q, Zhong W, Zhang H, Wang Q, Peng Y et al (2015) Treatment of cholestatic fibrosis by altering gene expression of Cthrc1: Implications for autoimmune and non-autoimmune liver disease. J Autoimmun 63:76\u201387. https:\/\/doi.org\/10.1016\/j.jaut.2015.07.010","journal-title":"J Autoimmun"},{"key":"12886_CR41","doi-asserted-by":"publisher","first-page":"570819","DOI":"10.3389\/fonc.2020.570819","volume":"10","author":"F Zhou","year":"2020","unstructured":"Zhou F, Shen D, Xiong Y, Cheng S, Xu H, Wang G et al (2020) CTHRC1 Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Kidney Renal Papillary Cell Carcinoma and Kidney Renal Clear Cell Carcinoma. Front Oncol 10:570819. https:\/\/doi.org\/10.3389\/fonc.2020.570819 PubMed PMID: 33628726; PubMed Central PMCID: PMC7898899","journal-title":"Front Oncol"},{"issue":"2","key":"12886_CR42","doi-asserted-by":"publisher","first-page":"101688","DOI":"10.1016\/j.gendis.2025.101688","volume":"13","author":"W Xie","year":"2026","unstructured":"Xie W, Fu Z, Skutella T, Jiang Q, Zhang R, Zhang Y (2026) CTHRC1 promotes the progression of clear cell renal cell carcinoma via the PI3K\/AKT\/GSK3\u03b2 signaling pathway. Genes Dis 13(2):101688. https:\/\/doi.org\/10.1016\/j.gendis.2025.101688","journal-title":"Genes Dis"},{"key":"12886_CR43","doi-asserted-by":"publisher","first-page":"102087","DOI":"10.1016\/j.bbrep.2025.102087","volume":"43","author":"Y Xing","year":"2025","unstructured":"Xing Y, An Y, Tian T, Pu L, Lu Z, Liang N et al (2025) Single-cell spatial transcriptomics reveals pathogenic mechanism of renal fibrosis in imiquimod-induced lupus nephritis in mice. Biochem Biophys Rep 43:102087. https:\/\/doi.org\/10.1016\/j.bbrep.2025.102087 PubMed PMID: 40641741; PubMed Central PMCID: PMC12242473","journal-title":"Biochem Biophys Rep"},{"issue":"4","key":"12886_CR44","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1097\/MNH.0000000000000988","volume":"33","author":"X Liao","year":"2024","unstructured":"Liao X, Scheidereit E, Kuppe C (2024) New tools to study renal fibrogenesis. Curr Opin Nephrol Hypertens 33(4):420\u2013426 doi:10.1097\/MNH.0000000000000988 PubMed PMID: 38587103; PubMed Central PMCID: PMC11139246","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"12886_CR45","doi-asserted-by":"publisher","first-page":"20807","DOI":"10.1038\/s41598-021-00324-4","volume":"11","author":"M Bruschi","year":"2021","unstructured":"Bruschi M, La Porta E, Panfoli I, Candiano G, Petretto A, Vidal E et al (2021) Proteomic profile of mesothelial exosomes isolated from peritoneal dialysis effluent of children with focal segmental glomerulosclerosis. Sci Rep 11:20807. https:\/\/doi.org\/10.1038\/s41598-021-00324-4 PubMed PMID: 34675284; PubMed Central PMCID: PMC8531449","journal-title":"Sci Rep"},{"issue":"9","key":"12886_CR46","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1016\/j.jpedsurg.2016.04","volume":"51","author":"C Qi","year":"2016","unstructured":"Qi C, Hu Y, Yang F, An H, Zhang J, Jin H et al (2016) Preliminary observations regarding the expression of collagen triple helix repeat-containing 1 is an independent prognostic factor for Wilms\u2019 tumor. J Pediatr Surg 51(9):1501\u20131506. https:\/\/doi.org\/10.1016\/j.jpedsurg.2016.04.016 PubMed PMID: 27230801","journal-title":"J Pediatr Surg"},{"issue":"6","key":"12886_CR47","doi-asserted-by":"publisher","first-page":"477","DOI":"10.3727\/096504016X14685034103716","volume":"24","author":"Xfei Jin","year":"2016","unstructured":"Jin Xfei, Li H, Zong S, Li Hyan (2016) Knockdown of Collagen Triple Helix Repeat Containing-1 Inhibits the Proliferation and Epithelial-to-Mesenchymal Transition in Renal Cell Carcinoma Cells. Oncol Res 24(6):477\u2013485. https:\/\/doi.org\/10.3727\/096504016X14685034103716 PubMed PMID: 28281968; PubMed Central PMCID: PMC7838749","journal-title":"Oncol Res"},{"issue":"1","key":"12886_CR48","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s13287-026-05030-4","volume":"17","author":"MC Doeser","year":"2026","unstructured":"Doeser MC, Raimann J, Beuke M, Kilcan Z, Menke AF, Klinkhammer BM et al (2026) Induction of fibrosis in human kidney organoids delineates mechanisms and therapeutic targets of fibrotic kidney disease. Stem Cell Res Ther 17(1):167. https:\/\/doi.org\/10.1186\/s13287-026-05030-4","journal-title":"Stem Cell Res Ther"},{"key":"12886_CR49","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s13287-025-04866-6","volume":"17","author":"S Li","year":"2025","unstructured":"Li S, Nlandu Q, van den Bosch TPP, Baan CC, Kramann R, Hoogduijn MJ (2025) Modeling kidney fibrosis and tubular regeneration in iPSC-derived kidney organoids. Stem Cell Res Ther 17:40. https:\/\/doi.org\/10.1186\/s13287-025-04866-6 PubMed PMID: 41413587; PubMed Central PMCID: PMC12829276","journal-title":"Stem Cell Res Ther"},{"issue":"5","key":"12886_CR50","doi-asserted-by":"publisher","first-page":"100336","DOI":"10.1016\/j.labinv.2024.100336","volume":"104","author":"X Yang","year":"2024","unstructured":"Yang X, Delsante M, Daneshpajouhnejad P, Fenaroli P, Mandell KP, Wang X et al (2024) Bile Acid Receptor Agonist Reverses Transforming Growth Factor-\u03b21-Mediated Fibrogenesis in Human Induced Pluripotent Stem Cells-Derived Kidney Organoids. Lab Investig J Tech Methods Pathol 104(5):100336. https:\/\/doi.org\/10.1016\/j.labinv.2024.100336 PubMed PMID: 38266922","journal-title":"Lab Investig J Tech Methods Pathol"},{"issue":"13","key":"12886_CR51","doi-asserted-by":"publisher","first-page":"5027","DOI":"10.7150\/ijbs.98839","volume":"20","author":"Y Zhong","year":"2024","unstructured":"Zhong Y, Wei B, Wang W, Chen J, Wu W, Liang L et al (2024) Single-Cell RNA-Sequencing Identifies Bone Marrow-Derived Progenitor Cells as a Main Source of Extracellular Matrix-Producing Cells Across Multiple Organ-Based Fibrotic Diseases. Int J Biol Sci 20(13):5027\u20135042. https:\/\/doi.org\/10.7150\/ijbs.98839","journal-title":"Int J Biol Sci"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12886-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12886-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12886-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:22:35Z","timestamp":1792160555000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12886-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,16]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12886"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12886-5","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,16]]},"assertion":[{"value":"23 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study did not involve human participants, human specimens, or animal subjects. Therefore, approval from a human or animal ethics committee was not required. The authors declare that they have no direct or indirect interests related to human or animal ethics committees.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1740"}}