{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:39:50Z","timestamp":1792798790585,"version":"4.5.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100013222","name":"Vaal University of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013222","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypertension (HTN) is a key cardiovascular risk factor, with its pathogenesis remaining incompletely understood. Blood pressure (BP) regulation involves the Renin\u2013Angiotensin\u2013Aldosterone System (RAAS), including the Angiotensin-converting enzyme (ACE), Angiotensin I (Ang I) and Angiotensin II (Ang II). The rs699 variant (M235T) may influence BP via the RAAS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to evaluate the relationships between the rs699 genotypes, RAAS parameters, BP, Body mass index (BMI) and gender in a black elderly population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were collected from 48 participants aged \u226560\u00a0years, using World Health Organization (WHO) obesity guidelines and South African Hypertension Society (SAHS) 2019 standards for HTN categories. Statistical analysis was performed using IBM SPSS version 27 and Python 3.14.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Most participants possessed the rs699 variant (GG: 93.8%, AG: 4.2%). ACE levels were low in 64.6%, while Ang II was elevated in the same percentage. The majority were classified as hypertensive and obese. No significant associations were found between the rs699 variant and ACE, Ang I, Ang II, HTN, BMI or gender, though BMI showed sex-related differences in females.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest no significant association of the rs699 variant on RAAS or cardiometabolic parameters within the study population, warranting cautious interpretation. These findings require validation in larger and more diverse populations, as meaningful statistical inferences cannot be drawn from the current data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11033-026-12994-2","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T10:10:30Z","timestamp":1792750230000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The AGT M235T variant and renin\u2013angiotensin\u2013aldosterone system parameters in a predominantly hypertensive elderly black South African cohort: a hypothesis-generating descriptive case series"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9246-4133","authenticated-orcid":false,"given":"Christa Johanna","family":"Grobler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8975-5693","authenticated-orcid":false,"given":"Wilna","family":"Oldewage-Theron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9148-9224","authenticated-orcid":false,"given":"Joseph Musonda","family":"Chalwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"issue":"4","key":"12994_CR1","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41581-019-0244-2","volume":"16","author":"KT Mills","year":"2020","unstructured":"Mills KT, Stefanescu A, He J (2020) The global epidemiology of hypertension. Nat Rev Nephrol 16(4):223\u2013237. https:\/\/doi.org\/10.1038\/s41581-019-0244-2","journal-title":"Nat Rev Nephrol"},{"issue":"8","key":"12994_CR2","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/s41581-024-00838-w","volume":"20","author":"BA Nguyen","year":"2024","unstructured":"Nguyen BA, Alexander MR, Harrison DG (2024) Immune mechanisms in the pathophysiology of hypertension. Nat Rev Nephrol 20(8):530\u2013540. https:\/\/doi.org\/10.1038\/s41581-024-00838-w","journal-title":"Nat Rev Nephrol"},{"issue":"6","key":"12994_CR3","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.40725","volume":"15","author":"AK Kanugula","year":"2023","unstructured":"Kanugula AK, Kaur J, Batra J, Ankireddypalli AR, Velagapudi R (2023) Renin-angiotensin system: updated understanding and role in physiological and pathophysiological states. Cureus 15(6):e40725. https:\/\/doi.org\/10.7759\/cureus.40725","journal-title":"Cureus"},{"issue":"5","key":"12994_CR4","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s00424-024-02908-1","volume":"476","author":"H Triebel","year":"2024","unstructured":"Triebel H, Castrop H (2024) The renin angiotensin aldosterone system. Pflug Arch Eur J Physiol 476(5):705\u2013713. https:\/\/doi.org\/10.1007\/s00424-024-02908-1","journal-title":"Pflug Arch Eur J Physiol"},{"issue":"3","key":"12994_CR5","first-page":"165","volume":"35","author":"A Melake","year":"2025","unstructured":"Melake A, Jegnie M (2025) Angiotensinogen M235t gene polymorphism and risk of ischemic heart disease complication among patients with hypertension in the ethiopian population. Ethiop J Health Sci 35(3):165","journal-title":"Ethiop J Health Sci"},{"issue":"1","key":"12994_CR6","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-5-7","volume":"5","author":"Y-H Say","year":"2005","unstructured":"Say Y-H, Ling K-H, Duraisamy G, Isaac S, Rosli R (2005) Angiotensinogen M235t gene variants and its association with essential hypertension and plasma renin activity in Malaysian subjects: a case control study. BMC Cardiovasc Disord 5(1):7. https:\/\/doi.org\/10.1186\/1471-2261-5-7","journal-title":"BMC Cardiovasc Disord"},{"issue":"11","key":"12994_CR7","doi-asserted-by":"publisher","first-page":"4331","DOI":"10.1210\/jcem.85.11.6932","volume":"85","author":"M Azizi","year":"2000","unstructured":"Azizi M, Hallouin M-C, Jeunemaitre X, Guyene TT, M\u00e9nard J (2000) Influence of the M235t polymorphism of human angiotensinogen (Agt) on plasma Agt and renin concentrations after ethinylestradiol administration. J Clin Endocrinol Metab 85(11):4331\u20134337. https:\/\/doi.org\/10.1210\/jcem.85.11.6932","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"12994_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/jpm14030273","volume":"14","author":"H Alhawari","year":"2024","unstructured":"Alhawari H, Jarrar Y, Zihlif M, Wahbeh A, Alshelleh S, Alhabahbeh R, Abdelrazaq D (2024) The association of M235t genetic polymorphism in angiotensinogen gene and other non-genetic factors with essential hypertension among Jordanian patients. J Pers Med 14(3):273","journal-title":"J Pers Med"},{"key":"12994_CR9","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000079007.40884.5C","author":"AA Sethi","year":"2003","unstructured":"Sethi AA, Nordestgaard BG, Tybj\u00e6rg-Hansen A (2003) Angiotensinogen gene polymorphism, plasma angiotensinogen, and risk of hypertension and ischemic heart disease. Arterioscler Thromb Vasc Biol. https:\/\/doi.org\/10.1161\/01.ATV.0000079007.40884.5C","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"12994_CR10","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41371-024-00913-6","volume":"39","author":"LF Gafane-Matemane","year":"2025","unstructured":"Gafane-Matemane LF, Craig A, Kruger R, Alaofin OS, Ware LJ, Jones ESW, Kengne AP (2025) Hypertension in Sub-Saharan Africa: the current profile, recent advances, gaps, and priorities. J Hum Hypertens 39(2):95\u2013110. https:\/\/doi.org\/10.1038\/s41371-024-00913-6","journal-title":"J Hum Hypertens"},{"key":"12994_CR11","unstructured":"WHO. Global Report on Hypertension 2023: The Race against a Silent Killer. Online: World Health Organization, https:\/\/www.who.int\/publications\/i\/item\/9789240081062."},{"issue":"6","key":"12994_CR12","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.85622","volume":"17","author":"A Ambreen","year":"2025","unstructured":"Ambreen A, Farooq M, Islam ZA, Akhtar H, Fatima SK, Ullah H (2025) Prevalence and awareness of hypertension among older adults. Cureus 17(6):e85622. https:\/\/doi.org\/10.7759\/cureus.85622","journal-title":"Cureus"},{"issue":"12","key":"12994_CR13","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1093\/cvr\/cvaf125","volume":"121","author":"P Olowoyo","year":"2025","unstructured":"Olowoyo P, Okekunle AP, Asowata OJ, Atolani S, Morsy MI, Caiazzo E, Gaye B, Kadan DD, Bruzzese D, Guzik TJ, Maffia P, Owolabi MO (2025) Prevalence of hypertension in Africa in the last two decades: systematic review and meta-analysis. Cardiovasc Res 121(12):1815\u20131829. https:\/\/doi.org\/10.1093\/cvr\/cvaf125","journal-title":"Cardiovasc Res"},{"issue":"5","key":"12994_CR14","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s40292-025-00725-w","volume":"32","author":"IV Freire","year":"2025","unstructured":"Freire IV, Ribeiro IJS, Casotti CA, Andrade D, Bezerra DD, Teixeira JRB, Barbosa AAL, Campos LCG, Pereira R (2025) Different polymorphisms of the renin-angiotensin-aldosterone system genes are associated with poorer blood pressure control in hypertensive older adults. High Blood Press Cardiovasc Prev 32(5):523\u2013532. https:\/\/doi.org\/10.1007\/s40292-025-00725-w","journal-title":"High Blood Press Cardiovasc Prev"},{"issue":"4","key":"12994_CR15","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/sj.ejhg.5201789","volume":"15","author":"H Schelleman","year":"2007","unstructured":"Schelleman H, Klungel OH, Witteman JCM, Breteler MMB, Yazdanpanah M, Danser AHJ, Hofman A, van Duijn CM, de Boer A, Stricker BHC (2007) Angiotensinogen M235t polymorphism and the risk of myocardial infarction and stroke among hypertensive patients on ACE-inhibitors or \u03b2-blockers. Eur J Hum Genet 15(4):478\u2013484. https:\/\/doi.org\/10.1038\/sj.ejhg.5201789","journal-title":"Eur J Hum Genet"},{"key":"12994_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.05.010","author":"J Simino","year":"2014","unstructured":"Simino J, Shi G, Bis JC, Chasman DI, Ehret GB, Xiangjun G et al (2014) \"Gene-age interactions in blood pressure regulation: a large-scale investigation with the charge global Bpgen and Icbp consortia. American J Human Gen. https:\/\/doi.org\/10.1016\/j.ajhg.2014.05.010","journal-title":"American J Human Gen"},{"issue":"12","key":"12994_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12121291","volume":"12","author":"M Shahid","year":"2022","unstructured":"Shahid M, Rehman K, Akash MSH, Suhail S, Kamal S, Imran M, Assiri MA (2022) Genetic polymorphism in angiotensinogen and its association with cardiometabolic diseases. Metabolites 12(12):1291","journal-title":"Metabolites"},{"issue":"11","key":"12994_CR18","doi-asserted-by":"publisher","first-page":"12694","DOI":"10.3390\/cimb46110753","volume":"46","author":"JM Chalwe","year":"2024","unstructured":"Chalwe JM, Grobler CJ, Oldewage-Theron WH (2024) Correlation of eight (8) polymorphisms and their genotypes with the risk factors of cardiovascular disease in a black elderly population. Curr Issues Mol Biol 46(11):12694\u201312703","journal-title":"Curr Issues Mol Biol"},{"issue":"3","key":"12994_CR19","first-page":"533","volume":"28","author":"Y Jamshidi-Naeini","year":"2019","unstructured":"Jamshidi-Naeini Y, Bavil AK, Egal A, Oldewage-Theron W (2019) Hemoglobin and ferritin concentrations are positively associated with blood pressure and hypertension risk in older adults: a retrospective cross-sectional study, sharpeville, South Africa. Asia Pac J Clin Nutr 28(3):533\u2013543","journal-title":"Asia Pac J Clin Nutr"},{"key":"12994_CR20","doi-asserted-by":"publisher","unstructured":"Oldewage-Theron, Wilna, and Christa Grobler. (2021) \"double burden of poverty and cardiovascular disease risk among low-resource communities in South Africa.\" in lifestyle and epidemiology - the double burden of poverty and cardiovascular diseases in African populations, edited by Kotsedi Daniel Monyeki and Han C. G. Kemper. London: IntechOpen. https:\/\/doi.org\/10.5772\/intechopen.95992.","DOI":"10.5772\/intechopen.95992"},{"issue":"1","key":"12994_CR21","first-page":"100","volume":"7","author":"W Oldewage-Theron","year":"2018","unstructured":"Oldewage-Theron W, Agal A, Grobler C (2018) Metabolic syndrome of freeliving elderly FROM Sharpeville, South Africa: a prospective cohort study with 10-year follow-up. J Aging Res Clin Pract 7(1):100\u2013106","journal-title":"J Aging Res Clin Pract"},{"key":"12994_CR22","doi-asserted-by":"publisher","DOI":"10.1097\/NT.0000000000000092","author":"FQ Nuttall","year":"2015","unstructured":"Nuttall FQ (2015) Body mass index: obesity, BMI, and health: a critical review. Nutr Today. https:\/\/doi.org\/10.1097\/NT.0000000000000092","journal-title":"Nutr Today"},{"key":"12994_CR23","unstructured":"WHO. \"Obesity and Overweight.\" World Health Organization, https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight (accessed 01\u201307\u201326)."},{"issue":"2","key":"12994_CR24","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1097\/MBP.0b013e3282f3fb2e","volume":"13","author":"A De Greeff","year":"2008","unstructured":"De Greeff A, Arora J, Hervey S, Liu B, Shennan A (2008) Accuracy assessment of the Tensoval Duo Control according to the British and European Hypertension Societies standards. Blood Press Monit 13(2):111\u2013116","journal-title":"Blood Press Monit"},{"issue":"5","key":"12994_CR25","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1038\/ejhg.2010.242","volume":"19","author":"L Southam","year":"2011","unstructured":"Southam L, Panoutsopoulou K, Rayner NW, Chapman K, Durrant C, Ferreira T, Arden N, Carr A, Deloukas P, Doherty M, Loughlin J, McCaskie A, Ollier WER, Ralston S, Spector TD, Valdes AM, Wallis GA, Wilkinson JM, Marchini J, Zeggini E, Ogen consortium the arc (2011) The effect of genome-wide association scan quality control on imputation outcome for common variants. Eur J Hum Genet 19(5):610\u2013614. https:\/\/doi.org\/10.1038\/ejhg.2010.242","journal-title":"Eur J Hum Genet"},{"issue":"1","key":"12994_CR26","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/biomet\/80.1.27","volume":"80","author":"D Firth","year":"1993","unstructured":"Firth D (1993) Bias reduction of maximum likelihood estimates. Biometrika 80(1):27\u201338. https:\/\/doi.org\/10.1093\/biomet\/80.1.27","journal-title":"Biometrika"},{"issue":"14","key":"12994_CR27","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1002\/sim.7273","volume":"36","author":"R Puhr","year":"2017","unstructured":"Puhr R, Heinze G, Nold M, Lusa L, Geroldinger A (2017) Firth\u2019s logistic regression with rare events: accurate effect estimates and predictions? Stat Med 36(14):2302\u20132317","journal-title":"Stat Med"},{"issue":"4","key":"12994_CR28","doi-asserted-by":"publisher","first-page":"406S","DOI":"10.1378\/chest.128.4_MeetingAbstracts.406S-b","volume":"128","author":"Z Khiangte","year":"2005","unstructured":"Khiangte Z, Bluth MH, Hardin R, Kamel E, Mueller CM, Chawla S, Norowitz TS, Zenilman M, Pincus M (2005) Serum angiotensin converting enzyme (Ace) in patients with acute pulmonary thromboembolism. Chest 128(4):406S. https:\/\/doi.org\/10.1378\/chest.128.4_MeetingAbstracts.406S-b","journal-title":"Chest"},{"issue":"1","key":"12994_CR29","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04518-2","volume":"27","author":"N Pode-Shakked","year":"2023","unstructured":"Pode-Shakked N, Ceschia G, Rose JE, Goldstein SL, Stanski NL, Investigators the Genomics of Pediatric Septic Shock (2023) Increasing angiotensin-converting enzyme concentrations and absent angiotensin-converting enzyme activity are associated with adverse kidney outcomes in pediatric septic shock. Crit Care 27(1):230. https:\/\/doi.org\/10.1186\/s13054-023-04518-2","journal-title":"Crit Care"},{"key":"12994_CR30","unstructured":"Labor_Diagnostika_Nord. (2022) \"Plasma Renin Activity (Pra) Elisa (Catalog No. Ms E-5600) [Kit].\" LDN. https:\/\/www.ldn.de\/wp-content\/uploads\/IFU-MS-E-5600-V7.0_wz.pdf."},{"key":"12994_CR31","unstructured":"Clinical_Laboratory_Reference_Values. \"Clinical Laboratory Reference Values.\" In Laboratory Medicine: The Diagnosis of Disease in the Clinical Laboratory, edited by Michael Laposata. New York, NY: McGraw-Hill Education, 2014accessmedicine.mhmedical.com\/content.aspx?aid=1104501691."},{"issue":"1","key":"12994_CR32","first-page":"282","volume":"10","author":"MJ Herzog","year":"2025","unstructured":"Herzog MJ, M\u00fcller P, Lechner K, Stiebler M, Arndt P, Kunz M, Ahrens D, Schmei\u00dfer A, Schreiber S, Braun-Dullaeus RC (2025) Arterial stiffness and vascular aging: mechanisms prevention and therapy. Sign Trans Targ Ther 10(1):282","journal-title":"Sign Trans Targ Ther"},{"issue":"1","key":"12994_CR33","doi-asserted-by":"publisher","first-page":"80","DOI":"10.21037\/gs.2019.12.03","volume":"9","author":"OA Shariq","year":"2020","unstructured":"Shariq OA, McKenzie TJ (2020) Obesity-related hypertension: a review of pathophysiology, management, and the role of metabolic surgery. Gland Surg 9(1):80\u201393","journal-title":"Gland Surg"},{"issue":"10","key":"12994_CR34","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","volume":"14","author":"C Franceschi","year":"2018","unstructured":"Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A (2018) Inflammaging: a new immune\u2013metabolic viewpoint for age-related diseases. Nat Rev Endocrinol 14(10):576\u2013590. https:\/\/doi.org\/10.1038\/s41574-018-0059-4","journal-title":"Nat Rev Endocrinol"},{"key":"12994_CR35","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13293-017-0128-8","volume":"8","author":"A Fern\u00e1ndez-Atucha","year":"2017","unstructured":"Fern\u00e1ndez-Atucha A, Izagirre A, Fraile-Berm\u00fadez AB, Kortajarena M, Larrinaga G, Martinez-Lage P, Echevarr\u00eda E, Gil J (2017) Sex differences in the aging pattern of renin-angiotensin system serum peptidases. Biol Sex Differ 8:5","journal-title":"Biol Sex Differ"},{"issue":"14","key":"12994_CR36","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1161\/01.CIR.97.14.1411","volume":"97","author":"NJ Brown","year":"1998","unstructured":"Brown NJ, Vaughan DE (1998) Angiotensin-converting enzyme inhibitors. Circulation 97(14):1411\u20131420","journal-title":"Circulation"},{"issue":"21","key":"12994_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/JCI195633","volume":"135","author":"C Cosarderelioglu","year":"2025","unstructured":"Cosarderelioglu C, Abadir PM (2025) Revisiting renin-angiotensin-aldosterone system in aging: translational insights from bench to bedside and back. J Clin Invest 135(21):1\u20132","journal-title":"J Clin Invest"},{"key":"12994_CR38","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1177\/14703203010020013001","volume":"1","author":"LG Navar","year":"2001","unstructured":"Navar LG, Mitchell KD, Harrison-Bernard LM, Kobori H, Nishiyama A (2001) Intrarenal angiotensin ii levels in normal and hypertensive states. J Renin-Angio Aldos Syst. 1:176\u2013184","journal-title":"J Renin-Angio Aldos Syst."},{"key":"12994_CR39","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303587","author":"L te Riet","year":"2015","unstructured":"te Riet L, van Esch JHM, Roks AJM, van den Meiracker AH, Jan Danser AH (2015) Hypertension. Circ Res. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.303587","journal-title":"Circ Res"},{"issue":"6","key":"12994_CR40","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1161\/HYPERTENSIONAHA.108.111294","volume":"51","author":"DW Wray","year":"2008","unstructured":"Wray DW, Nishiyama SK, Harris RA, Richardson RS (2008) Angiotensin II in the elderly. Hypertension 51(6):1611\u20131616","journal-title":"Hypertension"},{"issue":"1","key":"12994_CR41","first-page":"23","volume":"8","author":"JL Zhuo","year":"2007","unstructured":"Zhuo JL, Li XC (2007) Novel roles of intracrine angiotensin ii and signalling mechanisms in kidney cells. J Ren Angio Aldost Sys. 8(1):23\u201333","journal-title":"J Ren Angio Aldost Sys."},{"key":"12994_CR42","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.305697","author":"JE Hall","year":"2015","unstructured":"Hall JE, Jussara M, Alexandre A, Silva D, Wang Z (2015) Obesity-Induced Hypertension. Circ Res. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.305697","journal-title":"Circ Res"},{"issue":"2","key":"12994_CR43","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1161\/HYPERTENSIONAHA.114.00920","volume":"64","author":"K Rahmouni","year":"2014","unstructured":"Rahmouni K (2014) Obesity-associated hypertension: recent progress in deciphering the pathogenesis. Hypertension 64(2):215\u2013221","journal-title":"Hypertension"},{"key":"12994_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.genrep.2019.100421","volume":"16","author":"JK Fajar","year":"2019","unstructured":"Fajar JK, Pikir BS, Sidarta EP, Saka PNB, Akbar RR, Tamara F, Mayasari ED, Gunawan A, Heriansyah T (2019) The genes polymorphism of angiotensinogen (Agt) M235t and Agt T174m in patients with essential hypertension: a meta-analysis. Gene Rep 16:100421","journal-title":"Gene Rep"},{"issue":"1","key":"12994_CR45","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0092-8674(92)90275-H","volume":"71","author":"X Jeunemaitre","year":"1992","unstructured":"Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, Hunt SC, Hopkins PN, Williams RR, Lalouel JM et al (1992) Molecular basis of human hypertension: role of angiotensinogen. Cell 71(1):169\u2013180","journal-title":"Cell"},{"issue":"1","key":"12994_CR46","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1291\/hypres.26.47","volume":"26","author":"M Matsubara","year":"2003","unstructured":"Matsubara M, Metoki H, Katsuya T, Kikuya M, Suzuki M, Michimata M, Araki T, Hozawa A, Tsuji I, Ogihara T, Imai Y (2003) T+ 31C polymorphism (M235T) of the angiotensinogen gene and home blood pressure in the Japanese general population: the ohasama study. Hyperten Res 26(1):47\u201352","journal-title":"Hyperten Res"},{"issue":"4","key":"12994_CR47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0346614","volume":"21","author":"NH Maamor","year":"2026","unstructured":"Maamor NH, Cengnata A, Pan Y, Ismail JR, Malek KA, Williams GH, Yusoff K, Boon-Peng H (2026) Genetic association of the renin-angiotensin-aldosterone system with hypertension among the Malays and their adaptation to climate change. PLoS ONE 21(4):e0346614","journal-title":"PLoS ONE"},{"issue":"2","key":"12994_CR48","first-page":"102","volume":"10","author":"NR Powell","year":"2024","unstructured":"Powell NR, Shugg T, Leighty J, Martin M, Kreutz RP, Eadon MT, Lai D, Lu T, Skaar TC (2024) Analysis of the combined effect of Rs699 and Rs5051 on angiotensinogen expression and hypertension. Chron Dis Transl Med 10(2):102\u2013117","journal-title":"Chron Dis Transl Med"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12994-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12994-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12994-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:03:59Z","timestamp":1792796639000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12994-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,23]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12994"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12994-2","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,23]]},"assertion":[{"value":"20 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1790"}}