{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:39:49Z","timestamp":1792798789833,"version":"4.5.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Kunming Health Science and Technology Talent Cultivation Program","award":["2024-SW (Reserve)-52"],"award-info":[{"award-number":["2024-SW (Reserve)-52"]}]},{"name":"Yunnan Provincial Clinical Medical Center Research Project","award":["2024YNLCYXZX0435"],"award-info":[{"award-number":["2024YNLCYXZX0435"]}]},{"name":"Kunming Health Science and Technology Talent Cultivation Program","award":["2025-SW (Technical)-15"],"award-info":[{"award-number":["2025-SW (Technical)-15"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11033-026-12999-x","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T10:10:29Z","timestamp":1792750229000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["TRIM27 enhances NF-\u03baB\/MAPK activation by ubiquitinating and degrading TRAF3 to drive asthma-induced airway inflammation"],"prefix":"10.1007","volume":"53","author":[{"given":"Juan","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"key":"12999_CR1","doi-asserted-by":"publisher","first-page":"246","DOI":"10.3389\/fped.2019.00246","volume":"7","author":"CUSTOVICA DHARMAGE S C, PERRET J L","year":"2019","unstructured":"Dharmage SC, Perret JL, Custovic A (2019) Epidemiology of Asthma in Children and Adults. Front Pediatr 7:246","journal-title":"Front Pediatr"},{"issue":"1","key":"12999_CR2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.arbres.2024.09.007","volume":"61","author":"A TIOTIU","year":"2025","unstructured":"Tiotiu A, Steiropoulos P (2025) Airway Remodeling in Asthma: Mechanisms, Diagnosis, Treatment, and Future Directions. Arch Bronconeumol 61(1):31\u201340","journal-title":"Arch Bronconeumol"},{"issue":"3","key":"12999_CR3","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.mucimm.2025.03.003","volume":"18","author":"DORSCHEID","year":"2025","unstructured":"Dorscheid D, Gauvreau GM, Georas SN et al (2025) Airway epithelial cells as drivers of severe asthma pathogenesis. Mucosal Immunol 18(3):524\u2013536","journal-title":"Mucosal Immunol"},{"key":"12999_CR4","doi-asserted-by":"publisher","first-page":"1149203","DOI":"10.3389\/fimmu.2023.1149203","volume":"14","author":"T JI","year":"2023","unstructured":"Ji T, Li H (2023) T-helper cells and their cytokines in pathogenesis and treatment of asthma. Front Immunol 14:1149203","journal-title":"Front Immunol"},{"issue":"1","key":"12999_CR5","doi-asserted-by":"publisher","first-page":"112437","DOI":"10.1016\/j.yexcr.2020.112437","volume":"400","author":"Y HAO","year":"2021","unstructured":"Hao Y, Bai S (2021) TRIM27-mediated ubiquitination of PPAR\u03b3 promotes glutamate-induced cell apoptosis and inflammation. Exp Cell Res 400(1):112437","journal-title":"Exp Cell Res"},{"key":"12999_CR6","doi-asserted-by":"publisher","first-page":"112199","DOI":"10.1016\/j.intimp.2024.112199","volume":"134","author":"K LIU","year":"2024","unstructured":"Liu K, Gu Y, Gu S et al (2024) Trim27 aggravates airway inflammation and oxidative stress in asthmatic mice via potentiating the NLRP3 inflammasome. Int Immunopharmacol 134:112199","journal-title":"Int Immunopharmacol"},{"issue":"10","key":"12999_CR7","first-page":"1076","volume":"43","author":"CHENS CHEN E J","year":"2021","unstructured":"Chen E J, Chen S, Zhou FL (2021) [Mechanism of TRIM27 promoting inflammatory response in lung cancer cells]. Zhonghua Zhong Liu Za Zhi 43(10):1076\u20131081","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"12999_CR8","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41392-019-0079-0","volume":"4","author":"ATHARI S S","year":"2019","unstructured":"Athari SS (2019) Targeting cell signaling in allergic asthma. Signal Transduct Target therapy 4:45","journal-title":"Signal Transduct Target therapy"},{"issue":"6","key":"12999_CR9","first-page":"883","volume":"41","author":"BAIL WU M Y, YU J E","year":"2021","unstructured":"Wu MY, Yu JE, Bai L et al (2021) Pingchuan formula improves allergic asthma in mice through inhibiting nuclear factor-kappa B \/ mitogen-activated protein kinase signaling pathway. J Tradit Chin Med 41(6):883\u2013890","journal-title":"J Tradit Chin Med"},{"key":"12999_CR10","doi-asserted-by":"crossref","unstructured":"Bai D, Sun T, Lu F et al (2022) Eupatilin Suppresses OVA-Induced Asthma by Inhibiting NF-\u03baB and MAPK and Activating Nrf2 Signaling Pathways in Mice. Int J Mol Sci, 23(3)","DOI":"10.3390\/ijms23031582"},{"key":"12999_CR11","doi-asserted-by":"crossref","unstructured":"Wang Q, Zhang YS, Peng QL (2022) Distinct skin morphological and transcriptomic profiles between wild and albino Oscar Astronotus ocellatus. Comparative biochemistry and physiology, Part D Genomics & proteomics, 41: 100944","DOI":"10.1016\/j.cbd.2021.100944"},{"key":"12999_CR12","doi-asserted-by":"crossref","unstructured":"Lin M, Ji X, Lv Y et al (2023) The Roles of TRAF3 in Immune Responses. Dis Markers, 2023: 7787803","DOI":"10.1155\/2023\/7787803"},{"key":"12999_CR13","doi-asserted-by":"crossref","unstructured":"Zhu Q, Yu T (2020) GAN S, TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination. J Exp Med, 217(7)","DOI":"10.1084\/jem.20192083"},{"key":"12999_CR14","doi-asserted-by":"crossref","unstructured":"Hu X, Cheng L, Xie J et al. (2026) RNF8 Relieves asthma-induced DNA Damage and Ferroptosis in Airway Epithelial Cells Through the AKT-NRF2 Axis. Appl Biochem Biotechnol","DOI":"10.1007\/s12010-026-05634-9"},{"key":"12999_CR15","doi-asserted-by":"publisher","first-page":"1201658","DOI":"10.3389\/fimmu.2023.1201658","volume":"14","author":"C RABY K L, MICHAELOUDES","year":"2023","unstructured":"Raby KL, Michaeloudes C, Tonkin J et al (2023) Mechanisms of airway epithelial injury and abnormal repair in asthma and COPD. Front Immunol 14:1201658","journal-title":"Front Immunol"},{"issue":"5","key":"12999_CR16","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/S2213-2600(25)00003-7","volume":"13","author":"regional Global","year":"2025","unstructured":"Global regional, national burden of asthma and atopic dermatitis (2025) 1990\u20132021, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021 [J]. Lancet Respir Med 13(5):425\u2013446","journal-title":"Lancet Respir Med"},{"issue":"1","key":"12999_CR17","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1186\/s12931-022-02207-2","volume":"23","author":"X RAO","year":"2022","unstructured":"Rao X, Dong H, Zhang W et al (2022) MiR-493-5p inhibits Th9 cell differentiation in allergic asthma by targeting FOXO1. Respir Res 23(1):286","journal-title":"Respir Res"},{"key":"12999_CR18","doi-asserted-by":"crossref","unstructured":"Hussain M (2024) LIU G. Eosinophilic Asthma: Pathophysiology and Therapeutic Horizons. Cells, 13(5)","DOI":"10.3390\/cells13050384"},{"issue":"9","key":"12999_CR19","doi-asserted-by":"publisher","first-page":"3236","DOI":"10.1111\/all.70384","volume":"81","author":"HARGISJM CANNATA A M, MCALEES J W","year":"2026","unstructured":"Cannata AM, Mcalees JW, Hargisj M et al (2026) MAIT Cells Suppress IgE-Mediated Asthma via IFN\u03b3-Dependent B Cell Regulation. Allergy 81(9):3236\u20133249","journal-title":"Allergy"},{"issue":"4","key":"12999_CR20","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1111\/all.16459","volume":"80","author":"C DOMINGO","year":"2025","unstructured":"Domingo C, Busse WW, Hanania NA et al (2025) The Direct and Indirect Role of IgE on Airway Epithelium in Asthma. Allergy 80(4):919\u2013931","journal-title":"Allergy"},{"issue":"12","key":"12999_CR21","doi-asserted-by":"publisher","first-page":"5296","DOI":"10.1002\/tox.24403","volume":"39","author":"F ZENG","year":"2024","unstructured":"Zeng F, Pang G (2024) Subway Fine Particles (PM(2.5))-Induced Pro-Inflammatory Response Triggers Airway Epithelial Barrier Damage Through the TLRs\/NF-\u03baB-Dependent Pathway In Vitro. Environ Toxicol 39(12):5296\u20135308","journal-title":"Environ Toxicol"},{"issue":"1","key":"12999_CR22","first-page":"69","volume":"17","author":"L HUA","year":"2021","unstructured":"Hua L, Liu Q, Li J et al (2021) Gene-gene and gene-environment interactions on cord blood total IgE in Chinese Han children. Allergy, asthma, and clinical immunology: official. J Can Soc Allergy Clin Immunol 17(1):69","journal-title":"J Can Soc Allergy Clin Immunol"},{"issue":"5","key":"12999_CR23","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1007\/s10528-021-10056-9","volume":"59","author":"D IMANI","year":"2021","unstructured":"Imani D, Dashti N (2021) Interleukin-10 Gene Promoter Polymorphisms and Susceptibility to Asthma: Systematic Review and Meta-analysis. Biochem Genet 59(5):1089\u20131115","journal-title":"Biochem Genet"},{"key":"12999_CR24","first-page":"102212","volume":"43","author":"Z JIN","year":"2025","unstructured":"Jin Z, Zhu Z, Jing X et al (2025) Ubiquitination regulates allergic asthma by affecting immune cells and immune responses. Biochem Biophys Rep 43:102212","journal-title":"Biochem Biophys Rep"},{"key":"12999_CR25","doi-asserted-by":"publisher","first-page":"02157","DOI":"10.3389\/fimmu.2020.02157","volume":"11","author":"W YANG","year":"2020","unstructured":"Yang W, Gu Z, Zhang H et al (2020) To TRIM the Immunity: From Innate to Adaptive Immunity. Front Immunol 11:02157","journal-title":"Front Immunol"},{"issue":"1","key":"12999_CR26","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1186\/s12890-024-03351-9","volume":"24","author":"N LI","year":"2024","unstructured":"Li N, Qiu G, Xu X et al (2024) TRIM11 Prevents Ferroptosis in model of asthma by UBE2N-TAX1BP1 signaling. BMC Pulm Med 24(1):542","journal-title":"BMC Pulm Med"},{"key":"12999_CR27","doi-asserted-by":"publisher","first-page":"112591","DOI":"10.1016\/j.intimp.2024.112591","volume":"138","author":"J XUE","year":"2024","unstructured":"Xue J, Jiang C, Chen X et al (2024) Trim31 deficiency exacerbates airway inflammation in asthma by enhancing the activation of the NLRP3 inflammasome. Int Immunopharmacol 138:112591","journal-title":"Int Immunopharmacol"},{"issue":"9","key":"12999_CR28","doi-asserted-by":"publisher","first-page":"6234","DOI":"10.1007\/s12010-025-05288-z","volume":"197","author":"F ZHU","year":"2025","unstructured":"Zhu F, Ji Y, You Q et al (2025) Asiaticoside Mitigates Chronic Obstructive Pulmonary Disease by Modulating TRIM27 Stability and Activating PGC-1\u03b1\/Nrf2 Signaling. Appl Biochem Biotechnol 197(9):6234\u20136254","journal-title":"Appl Biochem Biotechnol"},{"key":"12999_CR29","doi-asserted-by":"crossref","unstructured":"Xu J, Cao K, Liu X et al (2021) Punicalagin Regulates Signaling Pathways in Inflammation-Associated Chronic Diseases. Antioxidants (Basel, Switzerland), 11(1)","DOI":"10.3390\/antiox11010029"},{"issue":"7","key":"12999_CR30","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1159\/000537837","volume":"185","author":"J HUANG","year":"2024","unstructured":"Huang J, Cai H, Ye X et al (2024) Demethylzeylasteral (T-96) Alleviates Allergic Asthma via Inhibiting MAPK\/ERK and NF-\u03baB Pathway. Int Arch Allergy Immunol 185(7):631\u2013640","journal-title":"Int Arch Allergy Immunol"},{"issue":"1","key":"12999_CR31","first-page":"51","volume":"20","author":"Y LI","year":"2024","unstructured":"Li Y, Zhou Y, Liu L et al (2024) Osthole attenuates asthma-induced airway epithelial cell apoptosis and inflammation by suppressing TSLP\/NF-\u03baB-mediated inhibition of Th2 differentiation. Allergy, asthma, and clinical immunology: official. J Can Soc Allergy Clin Immunol 20(1):51","journal-title":"J Can Soc Allergy Clin Immunol"},{"issue":"3","key":"12999_CR32","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.3390\/biom5031266","volume":"5","author":"SCHULIGA M","year":"2015","unstructured":"Schuliga M (2015) NF-kappaB Signaling in Chronic Inflammatory Airway Disease. Biomolecules 5(3):1266\u20131283","journal-title":"Biomolecules"},{"issue":"8","key":"12999_CR33","doi-asserted-by":"publisher","first-page":"101091","DOI":"10.1016\/j.waojou.2025.101091","volume":"18","author":"J WANG","year":"2025","unstructured":"Wang J, Han D, Han L et al (2025) Protective effect of micheliolide against inflammation and oxidative stress in asthma through the MAPK\/NF-\u03baB signalling pathway. World Allergy Organ J 18(8):101091","journal-title":"World Allergy Organ J"},{"issue":"1","key":"12999_CR34","first-page":"7","volume":"9","author":"TAN Y Y","year":"2022","unstructured":"Tan YY, Zhou HQ, Lin YJ et al (2022) FGF2 is overexpressed in asthma and promotes airway inflammation through the FGFR\/MAPK\/NF-\u03baB pathway in airway epithelial cells. Mil Med Res 9(1):7","journal-title":"Mil Med Res"},{"issue":"1","key":"12999_CR35","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1186\/s12885-021-08562-5","volume":"21","author":"C XIAO","year":"2021","unstructured":"Xiao C, Zhang W (2021) TRIM27 interacts with I\u03bab\u03b1 to promote the growth of human renal cancer cells through regulating the NF-\u03baB pathway. BMC Cancer 21(1):841","journal-title":"BMC Cancer"},{"issue":"1","key":"12999_CR36","doi-asserted-by":"publisher","first-page":"334","DOI":"10.4049\/jimmunol.1401548","volume":"194","author":"C LALANI A I, MOORE C R, LUO","year":"2015","unstructured":"Lalani AI, Moore CR, Luo C et al (2015) Myeloid cell TRAF3 regulates immune responses and inhibits inflammation and tumor development in mice. J Immunol 194(1):334\u2013348","journal-title":"J Immunol"},{"issue":"11","key":"12999_CR37","doi-asserted-by":"publisher","first-page":"7060","DOI":"10.1007\/s12010-023-04434-9","volume":"195","author":"L SHANG","year":"2023","unstructured":"Shang L, Du Y, Zhao Y et al (2023) The Interaction of OTUB1 and TRAF3 Mediates NLRP3 Inflammasome Activity to Regulate TGF-\u03b21-induced BEAS-2B Cell Injury. Appl Biochem Biotechnol 195(11):7060\u20137074","journal-title":"Appl Biochem Biotechnol"},{"issue":"8","key":"12999_CR38","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1038\/s41418-023-01194-1","volume":"30","author":"JH SHI","year":"2023","unstructured":"Shi JH, Liu LN, Song DD et al (2023) TRAF3\/STAT6 axis regulates macrophage polarization and tumor progression. Cell Death Differ 30(8):2005\u20132016","journal-title":"Cell Death Differ"},{"key":"12999_CR39","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1186\/s12935-020-01595-z","volume":"20","author":"X DU","year":"2020","unstructured":"Du X, Wang S, Liu X et al (2020) MiR-1307-5p targeting TRAF3 upregulates the MAPK\/NF-\u03baB pathway and promotes lung adenocarcinoma proliferation. Cancer Cell Int 20:502","journal-title":"Cancer Cell Int"},{"issue":"Pt 1","key":"12999_CR40","doi-asserted-by":"publisher","first-page":"117936","DOI":"10.1016\/j.bcp.2026.117936","volume":"250","author":"D HU","year":"2026","unstructured":"Hu D, Zhao S, Jin Y et al (2026) RNF144B deficiency aggravated neuroinflammatory response induced by cerebral ischemic stroke via regulating TRAF3 ubiquitination. Biochem Pharmacol 250(Pt 1):117936","journal-title":"Biochem Pharmacol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12999-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12999-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-026-12999-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:03:54Z","timestamp":1792796634000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11033-026-12999-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,23]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["12999"],"URL":"https:\/\/doi.org\/10.1007\/s11033-026-12999-x","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,23]]},"assertion":[{"value":"15 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were approved by the Experimental Animal Ethics Committee of Yunnan Besitel Biotechnology Co., Ltd., and all of the animal experiments were conducted in accordance with the ARRIVE guidelines. The animal experiments in this study were conducted in the standard laboratory of Yunnan Besitel Biotechnology Co., Ltd.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1789"}}