{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:07:20Z","timestamp":1790208440412,"version":"4.1.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2010,6,15]],"date-time":"2010-06-15T00:00:00Z","timestamp":1276560000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycopathologia"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1007\/s11046-010-9328-z","type":"journal-article","created":{"date-parts":[[2010,6,14]],"date-time":"2010-06-14T20:11:14Z","timestamp":1276546274000},"page":"315-330","source":"Crossref","is-referenced-by-count":36,"title":["Pathogenesis of Pulmonary Cryptococcus gattii Infection: A Rat Model"],"prefix":"10.1007","volume":"170","author":[{"given":"Mark B.","family":"Krockenberger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Popchai","family":"Ngamskulrungroj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Trilles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Escandon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Dowd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Himmelreich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Canfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania C.","family":"Sorrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wieland","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,6,15]]},"reference":[{"key":"9328_CR1","doi-asserted-by":"crossref","DOI":"10.1128\/9781555818241","volume-title":"Cryptococcus neoformans","author":"A Casadevall","year":"1998","unstructured":"Casadevall A, Perfect JR. Cryptococcus neoformans. Washington, DC: ASM press; 1998."},{"key":"9328_CR2","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1099\/00221287-147-4-891","volume":"147","author":"T Boekhout","year":"2001","unstructured":"Boekhout T, Theelen B, Diaz M, Fell JW, Hop WC, Abeln EC, et al. Hybrid genotypes in the pathogenic yeast Cryptococcus neoformans. Microbiology. 2001;147:891\u2013907.","journal-title":"Microbiology"},{"key":"9328_CR3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3201\/eid0902.020246","volume":"9","author":"W Meyer","year":"2003","unstructured":"Meyer W, Castaneda A, Jackson S, Huynh M, Castaneda E. Molecular typing of IberoAmerican Cryptococcus neoformans isolates. Emerg Infect Dis. 2003;9:189\u201395.","journal-title":"Emerg Infect Dis"},{"key":"9328_CR4","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1128\/JCM.42.8.3865-3868.2004","volume":"42","author":"A Jenney","year":"2004","unstructured":"Jenney A, Pandithage K, Fisher DA, Currie BJ. Cryptococcus infection in tropical Australia. J Clin Microbiol. 2004;42:3865\u20138.","journal-title":"J Clin Microbiol"},{"key":"9328_CR5","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1086\/313992","volume":"31","author":"S Chen","year":"2000","unstructured":"Chen S, Sorrell T, Nimmo G, Speed B, Currie B, Ellis D, et al. Epidemiology and host- and variety-dependent characteristics of infection due to Cryptococcus neoformans in Australia and New Zealand. Australasian Cryptococcal Study Group. Clin Infect Dis. 2000;31:499\u2013508.","journal-title":"Clin Infect Dis"},{"key":"9328_CR6","doi-asserted-by":"crossref","first-page":"17258","DOI":"10.1073\/pnas.0402981101","volume":"101","author":"SE Kidd","year":"2004","unstructured":"Kidd SE, Hagen F, Tscharke RL, Huynh M, Bartlett KH, Fyfe M, et al. A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada). Proc Natl Acad Sci USA. 2004;101:17258\u201363.","journal-title":"Proc Natl Acad Sci USA"},{"key":"9328_CR7","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/mmy.39.2.155.168","volume":"39","author":"TC Sorrell","year":"2001","unstructured":"Sorrell TC. Cryptococcus neoformans variety gattii. Med Mycol. 2001;39:155\u201368.","journal-title":"Med Mycol"},{"key":"9328_CR8","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1751-0813.1996.tb10003.x","volume":"73","author":"R Malik","year":"1996","unstructured":"Malik R, Craig AJ, Wigney DI, Martin P, Love DN. Combination chemotherapy of canine and feline cryptococcosis using subcutaneously administered amphotericin B. Aust Vet J. 1996;73:124\u20138.","journal-title":"Aust Vet J"},{"key":"9328_CR9","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1751-0813.1997.tb14377.x","volume":"75","author":"R Malik","year":"1997","unstructured":"Malik R, Martin P, Wigney DI, Church DB, Bradley W, Bellenger CR, et al. Nasopharyngeal cryptococcosis. Aust Vet J. 1997;75:483\u20138.","journal-title":"Aust Vet J"},{"key":"9328_CR10","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1080\/13693780310001624547","volume":"42","author":"CR O\u2019Brien","year":"2004","unstructured":"O\u2019Brien CR, Krockenberger MB, Wigney DI, Martin P, Malik R. Retrospective study of feline and canine cryptococcosis in Australia from 1981 to 2001: 195 cases. Med Mycol. 2004;42:449\u201360.","journal-title":"Med Mycol"},{"key":"9328_CR11","doi-asserted-by":"crossref","unstructured":"Krockenberger M, Stalder K, Malik R, Canfield P. Cryptococcosis in Australian Wildlife. Microbiol Aust. 2005;26(2):69\u201371.","DOI":"10.1071\/MA05069"},{"key":"9328_CR12","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1080\/mmy.40.3.273.282","volume":"40","author":"MB Krockenberger","year":"2002","unstructured":"Krockenberger MB, Canfield PJ, Barnes J, Vogelnest L, Connolly J, Ley C. et al. Cryptococcus neoformans var. gattii in the koala (Phascolarctos cinereus): serological evidence for subclinical cryptococcosis. Med Mycol. 2002;40:273\u201382.","journal-title":"Med Mycol"},{"key":"9328_CR13","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/369378031000137242","volume":"41","author":"MB Krockenberger","year":"2003","unstructured":"Krockenberger MB, Canfield PJ, Malik R. Cryptococcus neoformans var. gattii in the koala (Phascolarctos cinereus): a review of 43 cases of cryptococcosis. Med Mycol. 2003;41:225\u201334.","journal-title":"Med Mycol"},{"key":"9328_CR14","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1128\/iai.29.2.633-641.1980","volume":"29","author":"TS Lim","year":"1980","unstructured":"Lim TS, Murphy JW, Cauley LK. Host-etiological agent interactions in intranasally and intraperitoneally induced Cryptococcosis in mice. Infect Immun. 1980;29:633\u201341.","journal-title":"Infect Immun"},{"key":"9328_CR15","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF01146198","volume":"126","author":"C Lima","year":"1994","unstructured":"Lima C, Vital JP. Olfactory mucosa response in guinea pigs following intranasal instillation with Cryptococcus neoformans. A histological and immunocytochemical study. Mycopathologia. 1994;126:65\u201373.","journal-title":"Mycopathologia"},{"key":"9328_CR16","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF00436442","volume":"88","author":"CM Riera","year":"1984","unstructured":"Riera CM, Masih DT, Rubinstein H, Nobile R, Vega VR. Effect of cyclophosphamide on rats experimentally infected with Cryptococcus neoformans. Mycopathologia. 1984;88:127\u201330.","journal-title":"Mycopathologia"},{"key":"9328_CR17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1128\/IAI.56.1.7-12.1988","volume":"56","author":"CH Mody","year":"1988","unstructured":"Mody CH, Toews GB, Lipscomb MF. Cyclosporin A inhibits the growth of Cryptococcus neoformans in a murine model. Infect Immun. 1988;56:7\u201312.","journal-title":"Infect Immun"},{"key":"9328_CR18","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.1128\/IAI.62.11.4755-4761.1994","volume":"62","author":"D Goldman","year":"1994","unstructured":"Goldman D, Lee SC, Casadevall A. Pathogenesis of pulmonary Cryptococcus neoformans infection in the rat. Infect Immun. 1994;62:4755\u201361.","journal-title":"Infect Immun"},{"key":"9328_CR19","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1348-0421.2002.tb02684.x","volume":"46","author":"K Kawakami","year":"2002","unstructured":"Kawakami K, Koguchi Y, Qureshi MH, Zhang T, Kinjo Y, Yara S, et al. Anti-CD11 b monoclonal antibody suppresses brain dissemination of Cryptococcus neoformans in mice. Microbiol Immunol. 2002;46:181\u20136.","journal-title":"Microbiol Immunol"},{"key":"9328_CR20","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1128\/IAI.60.9.3682-3688.1992","volume":"60","author":"E Blasi","year":"1992","unstructured":"Blasi E, Barluzzi R, Mazzolla R, Mosci P, Bistoni F. Experimental model of intracerebral infection with Cryptococcus neoformans: roles of phagocytes and opsonization. Infect Immun. 1992;60:3682\u20138.","journal-title":"Infect Immun"},{"key":"9328_CR21","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/path.1700890225","volume":"89","author":"AK Perceval","year":"1965","unstructured":"Perceval AK. Experimental Cryptococcosis: hypersensitivity and immunity. J Pathol Bacteriol. 1965;89:645\u201355.","journal-title":"J Pathol Bacteriol"},{"key":"9328_CR22","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1128\/AAC.33.10.1735","volume":"33","author":"JR Perfect","year":"1989","unstructured":"Perfect JR, Wright KA, Hobbs MM, Durack DT. Treatment of experimental cryptococcal meningitis and disseminated candidiasis with SCH39304. Antimicrob Agents Chemother. 1989;33:1735\u201340.","journal-title":"Antimicrob Agents Chemother"},{"key":"9328_CR23","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0035-9203(84)90034-8","volume":"78","author":"EM Scrimgeour","year":"1984","unstructured":"Scrimgeour EM, Purohit RG. Chronic pulmonary cryptococcosis in a Rattus rattus from Rabaul, Papua New Guinea. Trans R Soc Trop Med Hyg. 1984;78:827\u20138.","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"9328_CR24","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1128\/IAI.68.2.832-838.2000","volume":"68","author":"DL Goldman","year":"2000","unstructured":"Goldman DL, Lee SC, Mednick AJ, Montella L, Casadevall A. Persistent Cryptococcus neoformans pulmonary infection in the rat is associated with intracellular parasitism, decreased inducible nitric oxide synthase expression, and altered antibody responsiveness to cryptococcal polysaccharide. Infect Immun. 2000;68:832\u20138.","journal-title":"Infect Immun"},{"key":"9328_CR25","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s11046-005-0162-7","volume":"160","author":"S Chaturvedi","year":"2005","unstructured":"Chaturvedi S, Ren P, Narasipura SD, Chaturvedi V. Selection of Optimal Host Strain for Molecular Pathogenesis Studies on Cryptococcus gattii. Mycopathologia. 2005;160:207\u201315.","journal-title":"Mycopathologia"},{"key":"9328_CR26","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1038\/nature04220","volume":"437","author":"JA Fraser","year":"2005","unstructured":"Fraser JA, Giles SS, Wenink EC, Geunes-Boyer SG, Wright JR, Diezmann S, et al. Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak. Nature. 2005;437:1360\u20134.","journal-title":"Nature"},{"key":"9328_CR27","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1111\/j.1365-2958.2005.04503.x","volume":"55","author":"SD Narasipura","year":"2005","unstructured":"Narasipura SD, Chaturvedi V, Chaturvedi S. Characterization of Cryptococcus neoformans variety gattii SOD2 reveals distinct roles of the two superoxide dismutases in fungal biology and virulence. Mol Microbiol. 2005;55:1782\u2013800.","journal-title":"Mol Microbiol"},{"key":"9328_CR28","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1128\/EC.00213-06","volume":"6","author":"JK Hicks","year":"2007","unstructured":"Hicks JK, Heitman J. Divergence of protein kinase A catalytic subunits in Cryptococcus neoformans and Cryptococcus gattii illustrates evolutionary reconfiguration of a signaling cascade. Eukaryot Cell. 2007;6:413\u201320.","journal-title":"Eukaryot Cell"},{"key":"9328_CR29","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1080\/714031068","volume":"39","author":"MB Krockenberger","year":"2001","unstructured":"Krockenberger MB, Canfield PJ, Kozel TR, Shinoda T, Ikeda R, Wigney DI, et al. An immunohistochemical method that differentiates Cryptococcus neoformans varieties and serotypes in formalin-fixed paraffin-embedded tissues. Med Mycol. 2001;39:523\u201333.","journal-title":"Med Mycol"},{"key":"9328_CR30","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1590\/S0074-02762006000700001","volume":"101","author":"RG Ducati","year":"2006","unstructured":"Ducati RG, Ruffino-Netto A, Basso LA, Santos DS. The resumption of consumption\u2014a review on tuberculosis. Mem Inst Oswaldo Cruz. 2006;101:697\u2013714.","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"9328_CR31","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/ajcp\/65.1.83","volume":"65","author":"RD Baker","year":"1976","unstructured":"Baker RD. The primary pulmonary lymph node complex of cryptococcosis. Am J Clin Pathol. 1976;65:83\u201392.","journal-title":"Am J Clin Pathol"},{"key":"9328_CR32","first-page":"222","volume":"23","author":"MJ Decker","year":"1989","unstructured":"Decker MJ, Conrad KP, Strohl KP. Noninvasive oximetry in the rat. Biomed Instrum Technol. 1989;23:222\u20138.","journal-title":"Biomed Instrum Technol"},{"key":"9328_CR33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1148\/radiology.138.1.7455075","volume":"138","author":"KG Rao","year":"1981","unstructured":"Rao KG, Woodlief RM. Excessive right subdiaphragmatic fat: a potential diagnostic pitfall. Radiology. 1981;138:15\u20138.","journal-title":"Radiology"},{"key":"9328_CR34","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1165\/rcmb.2003-0213TR","volume":"30","author":"DP Schuster","year":"2004","unstructured":"Schuster DP, Kovacs A, Garbow J, Piwnica-Worms D. Recent advances in imaging the lungs of intact small animals. Am J Respir Cell Mol Biol. 2004;30:129\u201338.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"9328_CR35","first-page":"253","volume":"21","author":"WJ Schirmer","year":"1987","unstructured":"Schirmer WJ, Schirmer JM, Townsend MC, Fry DE. Imidazole and indomethacin improve hepatic perfusion in sepsis. Circ Shock. 1987;21:253\u20139.","journal-title":"Circ Shock"},{"key":"9328_CR36","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1567-1364.2006.00079.x","volume":"6","author":"TC Sorrell","year":"2006","unstructured":"Sorrell TC, Wright LC, Malik R, Himmelreich U. Application of proton nuclear magnetic resonance spectroscopy to the study of Cryptococcus and cryptococcosis. FEMS Yeast Res. 2006;6:558\u201366.","journal-title":"FEMS Yeast Res"},{"key":"9328_CR37","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1002\/pmic.200500347","volume":"6","author":"YS Lee","year":"2006","unstructured":"Lee YS, Chen PW, Tsai PJ, Su SH, Liao PC. Proteomics analysis revealed changes in rat bronchoalveolar lavage fluid proteins associated with oil mist exposure. Proteomics. 2006;6:2236\u201350.","journal-title":"Proteomics"},{"key":"9328_CR38","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/j.1445-5994.1993.tb04726.x","volume":"23","author":"D Fisher","year":"1993","unstructured":"Fisher D, Burrow J, Lo D, Currie B. Cryptococcus neoformans in tropical northern Australia: predominantly variant gattii with good outcomes. Aust N Z J Med. 1993;23:678\u201382.","journal-title":"Aust N Z J Med"},{"key":"9328_CR39","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1286-4579(03)00028-5","volume":"5","author":"U Himmelreich","year":"2003","unstructured":"Himmelreich U, Allen C, Dowd S, Malik R, Shehan BP, Mountford C, et al. Identification of metabolites of importance in the pathogenesis of pulmonary cryptococcoma using nuclear magnetic resonance spectroscopy. Microbes Infect. 2003;5:285\u201390.","journal-title":"Microbes Infect"},{"key":"9328_CR40","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.2460\/javma.2004.225.1716","volume":"225","author":"SJ Lester","year":"2004","unstructured":"Lester SJ, Kowalewich NJ, Bartlett KH, Krockenberger MB, Fairfax TM, Malik R. Clinicopathologic features of an unusual outbreak of cryptococcosis in dogs, cats, ferrets, and a bird: 38 cases (January to July 2003). J Am Vet Med Assoc. 2004;225:1716\u201322.","journal-title":"J Am Vet Med Assoc"},{"key":"9328_CR41","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1567-1364.2006.00055.x","volume":"6","author":"P Escandon","year":"2006","unstructured":"Escandon P, Sanchez A, Martinez M, Meyer W, Castaneda E. Molecular epidemiology of clinical and environmental isolates of the Cryptococcus neoformans species complex reveals a high genetic diversity and the presence of the molecular type VGII mating type a in Colombia. FEMS Yeast Res. 2006;6:625\u201335.","journal-title":"FEMS Yeast Res"},{"key":"9328_CR42","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1080\/13693780802512519","volume":"47","author":"S McGill","year":"2009","unstructured":"McGill S, Malik R, Saul N, Beetson S, Secombe C, Robertson I, Irwin P. Cryptococcosis in domestic animals in Western Australia: a retrospective study from 1995\u20132006. Med Mycol. 2009;47:625\u201339.","journal-title":"Med Mycol"},{"key":"9328_CR43","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0035-9203(97)90391-6","volume":"91","author":"RA Seaton","year":"1997","unstructured":"Seaton RA, Verma N, Haraqii S, Wembrii JP, Warrel DA. Visual loss in immunocompetent patients with Cryptococcus neoformans var. gattii meningitis. Trans R Soc Trop Med Hyg. 1997;91:44\u20139.","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"9328_CR44","doi-asserted-by":"crossref","unstructured":"Iqbal N, DeBess EE, Wohrle R, Sun B, Nett RJ, Ahlquist AM, Chiller T, Lockhart SR. Cryptococcus gattii Public Health Working Group. Correlation of genotype and in vitro susceptibilites of Cryptococcus gattii strains from the Pacific Northwest of the United States. J Clin Microbiol. 2010;48:539\u201344.","DOI":"10.1128\/JCM.01505-09"}],"container-title":["Mycopathologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-010-9328-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11046-010-9328-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-010-9328-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T12:53:17Z","timestamp":1635511997000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11046-010-9328-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,15]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["9328"],"URL":"https:\/\/doi.org\/10.1007\/s11046-010-9328-z","relation":{},"ISSN":["0301-486X","1573-0832"],"issn-type":[{"value":"0301-486X","type":"print"},{"value":"1573-0832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,15]]}}}