{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T14:54:56Z","timestamp":1780930496289,"version":"3.54.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"5-6","license":[{"start":{"date-parts":[[2012,11,22]],"date-time":"2012-11-22T00:00:00Z","timestamp":1353542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycopathologia"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1007\/s11046-012-9599-7","type":"journal-article","created":{"date-parts":[[2012,11,22]],"date-time":"2012-11-22T18:26:49Z","timestamp":1353608809000},"page":"463-475","source":"Crossref","is-referenced-by-count":12,"title":["DNA-hsp65 Vaccine as Therapeutic Strategy to Treat Experimental Chromoblastomycosis Caused by Fonsecaea Pedrosoi"],"prefix":"10.1007","volume":"175","author":[{"given":"Isaque Medeiros","family":"Siqueira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice Melo","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanna Karla","family":"de Medeiros N\u00f3brega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina Smidt","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Camila Oliveira","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio Souza","family":"Jer\u00f4nimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flor\u00eancio Figueiredo Cavalcante","family":"Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lio Lopes","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Sueli Soares","family":"Felipe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anam\u00e9lia Lorenzetti","family":"Bocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,11,22]]},"reference":[{"key":"9599_CR1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.clindermatol.2006.05.007","volume":"25","author":"R L\u00f3pez Mart\u00ednez","year":"2007","unstructured":"L\u00f3pez Mart\u00ednez R, M\u00e9ndez Tovar LJ. Chromoblastomycosis. Clin Dermatol. 2007;25:188\u201394.","journal-title":"Clin Dermatol"},{"key":"9599_CR2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/13693780802538001","volume":"47","author":"F Queiroz-Telles","year":"2009","unstructured":"Queiroz-Telles F, Esterre P, Perez-Blanco M, Vitale RG, Salgado CG, Bonifaz A. Chromoblastomycosis: an overview of clinical manifestations, diagnosis and treatment. Med Mycol. 2009;47:3\u201315.","journal-title":"Med Mycol"},{"key":"9599_CR3","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF01608337","volume":"422","author":"P Esterre","year":"1993","unstructured":"Esterre P, Peyrol S, Sainte-Marie D, Pradinaud R, Grimaud JA. Granulomatous reaction and tissue remodelling in the cutaneous lesion of chromomycosis. Virchows Archiv A Pathol Anat Histopathol. 1993;422:285\u201391.","journal-title":"Virchows Archiv A Pathol Anat Histopathol"},{"key":"9599_CR4","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/02681219280000351","volume":"30","author":"SR Farbiarz","year":"1992","unstructured":"Farbiarz SR, de Carvalho TU, Alviano C, De Souza W. Inhibitory effect of melanin on the interaction of Fonsecaea pedrosoi with mammalian cells in vitro. J Med Vet Mycol. 1992;30:265\u201373.","journal-title":"J Med Vet Mycol"},{"key":"9599_CR5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11046-005-0228-6","volume":"161","author":"AL Bocca","year":"2006","unstructured":"Bocca AL, Brito PPMS, Figueiredo F, Tosta CE. Inhibition of nitric oxide production by macrophages in chromoblastomycosis: a role for Fonsecaea pedrosoi melanin. Mycopathologia. 2006;161:195\u2013203.","journal-title":"Mycopathologia"},{"key":"9599_CR6","doi-asserted-by":"crossref","unstructured":"Cunha MML, Franzen AJ, Seabra SH, Herbst MH, Vugman, NV, Borba LP, De Souza W, Rosental S. Melanin in Fonsecaea pedrosoi: a trap for oxidative radicals. BMC Microbiol. 2010;10:80.","DOI":"10.1186\/1471-2180-10-80"},{"key":"9599_CR7","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1128\/CDLI.7.3.497-500.2000","volume":"7","author":"P Esterre","year":"2000","unstructured":"Esterre P, Jahevitra M, Andriantsimahavandy A. Humoral immune response in chromoblastomycosis during and after therapy. Clin Diagn Lab Immunol. 2000;7:497\u2013500.","journal-title":"Clin Diagn Lab Immunol"},{"key":"9599_CR8","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.micinf.2005.01.006","volume":"7","author":"MF Gimenes","year":"2005","unstructured":"Gimenes MF, Souza MG, Ferreira KS, Marques SG, Gon\u00e7alves AG, Santos VCL. Pedroso e Silva CDM, Almeida SR. Cytokines and lymphocyte proliferation in patients with different clinical forms of chromoblastomycosis. Microbes Infect. 2005;7:708\u201313.","journal-title":"Microbes Infect"},{"key":"9599_CR9","doi-asserted-by":"crossref","first-page":"651","DOI":"10.4269\/ajtmh.1989.40.651","volume":"40","author":"J Ahrens","year":"1989","unstructured":"Ahrens J, Graybill JR, Abishawl A, Tio FO, Rinaldi MG. Experimental murine chromomycosis mimicking chronic progressive human disease. Am J Trop Med Hyg. 1989;40:651\u20138.","journal-title":"Am J Trop Med Hyg"},{"key":"9599_CR10","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/ijd.1978.17.5.414","volume":"17","author":"CF Lopes","year":"1978","unstructured":"Lopes CF, Alvarenga RJ, Cisalpino EO, Resende MA, Oliveira LG. Six years\u2019 experience in treatment of chromomycosis with 5-fluorocytosine. Int J Dermatol. 1978;17:414\u20138.","journal-title":"Int J Dermatol"},{"issue":"Suppl 1","key":"9599_CR11","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1093\/clinids\/14.Supplement_1.S68","volume":"14","author":"M Diaz","year":"1992","unstructured":"Diaz M, Negroni R, Montero-Gei F, Castro LG, Sampaio SA, Borelli D, Restrepo A, Franco L, Bran JL, Arathoon EG. A Pan-American 5-year study of fluconazole therapy for deep mycoses in the immunocompetent host. Pan-American Study Group. Clin Infect Dis. 1992;14(Suppl 1):S68\u201376.","journal-title":"Clin Infect Dis"},{"key":"9599_CR12","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.7150\/ijbs.7.1230","volume":"7","author":"M Arce-Fonseca","year":"2011","unstructured":"Arce-Fonseca M, Ramos-Ligonio A, L\u00f3pez-Monte\u00f3n A, Salgado-Jim\u00e9nez B, Talam\u00e1s-Rohana P, Rosales-Encina JL. A DNA vaccine encoding for TcSSP4 induces protection against acute and chronic infection in experimental chagas disease. Int J Biol Sci. 2011;7:1230\u20138.","journal-title":"Int J Biol Sci"},{"key":"9599_CR13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1297-9716-43-59","volume":"43","author":"G Dom\u00ednguez-Bernal","year":"2012","unstructured":"Dom\u00ednguez-Bernal G, Horcajo P, Orden JA, De La Fuente R, Herrero-Gil A, Ord\u00f3\u00f1ez-Guti\u00e9rrez L, Carrion J. Mitigating an undesirable immune response of inherent susceptibility to cutaneous leishmaniosis in a mouse model: the role of the pathoantigenic HISA70 DNA vaccine. Vet Res. 2012;43:59.","journal-title":"Vet Res"},{"key":"9599_CR14","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1002\/eji.201040484","volume":"40","author":"W Wu","year":"2010","unstructured":"Wu W, Huang L, Mendez S. A live Leishmania major vaccine containing CpG motifs induces the de novo generation of Th17 cells in C57BL\/6 mice. Eur J Immunol. 2010;40:2517\u201327.","journal-title":"Eur J Immunol"},{"key":"9599_CR15","doi-asserted-by":"crossref","first-page":"8372","DOI":"10.1016\/j.vaccine.2007.10.012","volume":"25","author":"A Abdul-Wahid","year":"2007","unstructured":"Abdul-Wahid A, Faubert G. Mucosal delivery of a transmission-blocking DNA vaccine encoding Giardia lamblia CWP2 by Salmonella typhimurium bactofection vehicle. Vaccine. 2007;25:8372\u201383.","journal-title":"Vaccine"},{"key":"9599_CR16","doi-asserted-by":"crossref","first-page":"5911","DOI":"10.3748\/wjg.v13.i44.5911","volume":"13","author":"Q-L Gu","year":"2007","unstructured":"Gu Q-L, Huang X, Ren W-H, Shen L, Liu B-Y, Chen S-Y. Targeting hepatitis B virus antigens to dendritic cells by heat shock protein to improve DNA vaccine potency. World J Gastroenterol. 2007;13:5911\u20137.","journal-title":"World J Gastroenterol"},{"key":"9599_CR17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.4161\/hv.6.4.10172","volume":"6","author":"M Okada","year":"2010","unstructured":"Okada M, Kita Y. Tuberculosis vaccine development: the development of novel (preclinical) DNA vaccine. Hum Vaccin. 2010;6:297\u2013308.","journal-title":"Hum Vaccin"},{"key":"9599_CR18","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/gt.2008.179","volume":"16","author":"JL Li","year":"2009","unstructured":"Li JL, Liu HL, Zhang XR, Xu JP, Hu WK, Liang M, Chen SY, Hu F, Chu DT. A phase I trial of intratumoral administration of recombinant oncolytic adenovirus overexpressing HSP70 in advanced solid tumor patients. Gene Ther. 2009;16:376\u201382.","journal-title":"Gene Ther"},{"key":"9599_CR19","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1089\/088282402760312296","volume":"15","author":"MJ Oglesbee","year":"2002","unstructured":"Oglesbee MJ, Pratt M, Carsillo T. Role for heat shock proteins in the immune response to measles virus infection. Viral Immunol. 2002;15:399\u2013416.","journal-title":"Viral Immunol"},{"key":"9599_CR20","doi-asserted-by":"crossref","first-page":"5818","DOI":"10.4049\/jimmunol.169.10.5818","volume":"169","author":"M Scheckelhoff","year":"2002","unstructured":"Scheckelhoff M, Deepe GS. The protective immune response to heat shock protein 60 of Histoplasma capsulatum is mediated by a subset of V beta 8.1\/8.2\u00a0+\u00a0T cells. J Immunol. 2002;169:5818\u201326.","journal-title":"J Immunol"},{"key":"9599_CR21","doi-asserted-by":"crossref","first-page":"6945","DOI":"10.1128\/IAI.72.12.6945-6950.2004","volume":"72","author":"JC Ferraz","year":"2004","unstructured":"Ferraz JC, Stavropoulos E, Yang M, Coade S, Espitia C, Lowrie DB, Colston MJ, Tascon RE. A heterologous DNA priming-Mycobacterium bovis BCG boosting immunization strategy using mycobacterial Hsp70, Hsp65, and Apa antigens improves protection against tuberculosis in mice. Infect Immunol. 2004;72:6945\u201350.","journal-title":"Infect Immunol"},{"key":"9599_CR22","first-page":"20","volume":"74","author":"RC Matthews","year":"1991","unstructured":"Matthews RC, Burnie JP, Howat D, Rowland T, Walton F. Autoantibody to heat-shock protein 90 can mediate protection against systemic candidiasis. Immunology. 1991;74:20\u20134.","journal-title":"Immunology"},{"key":"9599_CR23","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1093\/infdis\/171.6.1668","volume":"171","author":"R Matthews","year":"1995","unstructured":"Matthews R, Hodgetts S, Burnie J. Preliminary assessment of a human recombinant antibody fragment to hsp90 in murine invasive candidiasis. J Infec Dis. 1995;171:1668\u201371.","journal-title":"J Infec Dis"},{"key":"9599_CR24","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/22326","volume":"400","author":"DB Lowrie","year":"1999","unstructured":"Lowrie DB, Tascon RE, Bonato VL, Lima VM, Faccioli LH, Stavropoulos E, Colston MJ, Hewinson RG, Moelling K, Silva CL. Therapy of tuberculosis in mice by DNA vaccination. Nature. 1999;400:269\u201371.","journal-title":"Nature"},{"key":"9599_CR25","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/sj.gt.3302418","volume":"12","author":"CL Silva","year":"2005","unstructured":"Silva CL, Bonato VLD, Coelho-Castelo AAM, De Souza AO, Santos SA, Lima KM, Faccioli LH, Rodrigues JM. Immunotherapy with plasmid DNA encoding mycobacterial hsp65 in association with chemotherapy is a more rapid and efficient form of treatment for tuberculosis in mice. Gene Ther. 2005;12:281\u20137.","journal-title":"Gene Ther"},{"key":"9599_CR26","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1479-0556-5-2","volume":"5","author":"L Paula de","year":"2007","unstructured":"de Paula L, Silva CL, Carlos D, Matias-Peres C, Sorgi CA, Soares EG, Souza PRM, Blad\u00e9s CR, Galleti FC, Bonato VL, Gon\u00e7alves ED, Silva EV, Faccioli LH. Comparison of different delivery systems of DNA vaccination for the induction of protection against tuberculosis in mice and guinea pigs. Genet Vaccines Ther. 2007;5:2.","journal-title":"Genet Vaccines Ther"},{"key":"9599_CR27","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s00436-005-0088-5","volume":"98","author":"EA Coelho","year":"2006","unstructured":"Coelho EA, Tavares CA, Lima KM, Silva CL, Rodrigues JM Jr, Fernandes AP. Mycobacterium hsp65 DNA entrapped into TDM-loaded PLGA microspheres induces protection in mice against Leishmania (Leishmania) major infection. Parasitol Res. 2006;98:568\u201375.","journal-title":"Parasitol Res"},{"key":"9599_CR28","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.vaccine.2008.10.022","volume":"27","author":"AM Ribeiro","year":"2009","unstructured":"Ribeiro AM, Bocca AL, Amaral AC, Faccioli LH, Galetti FCS, Z\u00e1rate-Blad\u00e9s CR, Figueiredo F, Silva CL, Felipe MS. DNAhsp65 vaccination induces protection in mice against Paracoccidioides brasiliensis infection. Vaccine. 2009;27:606\u201313.","journal-title":"Vaccine"},{"key":"9599_CR29","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.vaccine.2009.11.062","volume":"28","author":"AM Ribeiro","year":"2010","unstructured":"Ribeiro AM, Bocca AL, Amaral AC, Souza ACO, Faccioli LH, Coelho-Castelo AAM, Figueiredo F, Silva CL, Felipe MS. HSP65 DNA as therapeutic strategy to treat experimental paracoccidioidomycosis. Vaccine. 2010;28:1528\u201334.","journal-title":"Vaccine"},{"key":"9599_CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1479-0556-4-1","volume":"4","author":"AAM Coelho-Castelo","year":"2006","unstructured":"Coelho-Castelo AAM, Trombone AP, Rosada RS, Santos RR, Bonato VLD, Sartori A, Silva CL. Tissue distribution of a plasmid DNA encoding Hsp65 gene is dependent on the dose administered through intramuscular delivery. Genet Vaccines Ther. 2006;4:1.","journal-title":"Genet Vaccines Ther"},{"key":"9599_CR31","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1089\/104303403767740812","volume":"14","author":"AAM Coelho-Castelo","year":"2003","unstructured":"Coelho-Castelo AAM, Santos J\u00fanior RR, Bonato VLD, Jamur MC, Oliver C, Silva CL. B-lymphocytes in bone marrow or lymph nodes can take up plasmid DNA after intramuscular delivery. Hum Gene Ther. 2003;14:1279\u201385.","journal-title":"Hum Gene Ther"},{"key":"9599_CR32","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0006-291X(89)91067-X","volume":"165","author":"HH Schmidt","year":"1989","unstructured":"Schmidt HH, Wilke P, Evers B, B\u00f6hme E. Enzymatic formation of nitrogen oxides from l-arginine in bovine brain cytosol. Biochem Bioph Res Com. 1989;165:284\u201391.","journal-title":"Biochem Bioph Res Com"},{"key":"9599_CR33","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1126\/science.6451927","volume":"212","author":"LC Green","year":"1981","unstructured":"Green LC, Tannenbaum SR, Goldman P. Nitrate synthesis in the germfree and conventional rat. Science. 1981;212:56\u20138.","journal-title":"Science"},{"key":"9599_CR34","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s11046-006-0041-x","volume":"162","author":"VMF Gimenes","year":"2006","unstructured":"Gimenes VMF, Criado PR, Martins JEC, Almeida SR. Cellular immune response of patients with chromoblastomycosis undergoing antifungal therapy. Mycopathologia. 2006;162:97\u2013101.","journal-title":"Mycopathologia"},{"key":"9599_CR35","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s11046-011-9399-5","volume":"171","author":"MR Melo-J\u00fanior de","year":"2011","unstructured":"de Melo-J\u00fanior MR, de Lima-Neto RG, Lacerda AM, Beltr\u00e3o EIC. Comparative analysis of extracellular matrix and cellular carbohydrate expression in the sporotrichosis and chromoblastomycosis. Mycopathologia. 2011;171:403\u20139.","journal-title":"Mycopathologia"},{"key":"9599_CR36","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3109\/13693780902785320","volume":"48","author":"Z Xie","year":"2010","unstructured":"Xie Z, Zhang J, Xi L, Li X, Wang L, Lu C, Sun J. A chronic chromoblastomycosis model by Fonsecaea monophora in Wistar rat. Med Mycol. 2010;48:201\u20136.","journal-title":"Med Mycol"},{"key":"9599_CR37","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1439-0507.2009.01792.x","volume":"54","author":"AP Machado","year":"2011","unstructured":"Machado AP, Silva MRR, Fischman O. Local phagocytic responses after murine infection with different forms of Fonsecaea pedrosoi and sclerotic bodies originating from an inoculum of conidiogenous cells. Mycoses. 2011;54:202\u201311.","journal-title":"Mycoses"},{"key":"9599_CR38","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1128\/AAC.00220-06","volume":"50","author":"AF Marques","year":"2006","unstructured":"Marques AF, da Silva MB, Juliano MAP, Travassos LR, Taborda CP. Peptide immunization as an adjuvant to chemotherapy in mice challenged intratracheally with virulent yeast cells of Paracoccidioides brasiliensis. Antimicrob Agents Chemother. 2006;50:2814\u20139.","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"9599_CR39","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/j.1476-5381.2009.00617.x","volume":"159","author":"AC Amaral","year":"2010","unstructured":"Amaral AC, Marques AF, Mu\u00f1oz JE, Bocca AL, Simioni AR, Tedesco AC, Morais PC, Travassos LR, Taborda CP, Felipe MS. Poly(lactic acid-glycolic acid) nanoparticles markedly improve immunological protection provided by peptide P10 against murine paracoccidioidomycosis. Br J Pharmacol. 2010;159(5):1126\u201332.","journal-title":"Br J Pharmacol"},{"issue":"12\u201313","key":"9599_CR40","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.micinf.2008.07.027","volume":"10","author":"AF Marques","year":"2008","unstructured":"Marques AF, da Silva MB, Juliano MAP, Munh\u00f5z JE, Travassos LR, Taborda CP. Additive effect of P10 immunization and chemotherapy in anergic mice challenged intratracheally with virulent yeasts of Paracoccidioides brasiliensis. Microbes Infect. 2008;10(12\u201313):1251\u20138.","journal-title":"Microbes Infect"},{"key":"9599_CR41","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/978-0-387-34814-8_15","volume":"590","author":"T Zelante","year":"2007","unstructured":"Zelante T, Montagnoli C, Bozza S, Gaziano R, Bellocchio S, Bonifazi P, Moretti S, Moretti S, Fallarino F, Puccetti P, Romani L. Receptors and pathways in innate antifungal immunity: the implication for tolerance and immunity to fungi. Adv Exp Med Biol. 2007;590:209\u201321.","journal-title":"Adv Exp Med Biol"},{"key":"9599_CR42","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/02681219680000551","volume":"34","author":"S Rozental","year":"1996","unstructured":"Rozental S, Alviano CS, de Souza W. Fine structure and cytochemical study of the interaction between Fonsecaea pedrosoi and rat polymorphonuclear leukocyte. J Med Vet Mycol. 1996;34:323\u201330.","journal-title":"J Med Vet Mycol"},{"issue":"1","key":"9599_CR43","first-page":"61","volume":"6","author":"M Fa\u0142kowska-Podstawka","year":"2003","unstructured":"Fa\u0142kowska-Podstawka M, Wernicki A. Heat shock proteins in health and disease. Pol J Vet Sci. 2003;6(1):61\u201370.","journal-title":"Pol J Vet Sci"},{"key":"9599_CR44","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1146\/annurev.immunol.15.1.617","volume":"15","author":"JJ Donnelly","year":"1997","unstructured":"Donnelly JJ, Ulmer JB, Shiver JW, Liu MA. DNA vaccines. Annu Rev Immunol. 1997;15:617\u201348.","journal-title":"Annu Rev Immunol"},{"key":"9599_CR45","doi-asserted-by":"crossref","first-page":"518","DOI":"10.4049\/jimmunol.151.1.518","volume":"151","author":"IM Orme","year":"1993","unstructured":"Orme IM, Roberts AD, Griffin JP, Abrams JS. Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection. J Immunol. 1993;151:518\u201325.","journal-title":"J Immunol"},{"key":"9599_CR46","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1128\/IAI.66.2.800-806.1998","volume":"66","author":"LE Cano","year":"1998","unstructured":"Cano LE, Kashino SS, Arruda C, Andr\u00e9 D, Xidieh CF, Singer-Vermes LM, Vaz CA, Burger E, Calich VL. Protective role of gamma interferon in experimental pulmonary paracoccidioidomycosis. Infect Immunol. 1998;66:800\u20136.","journal-title":"Infect Immunol"},{"key":"9599_CR47","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.4049\/jimmunol.161.6.3056","volume":"161","author":"AL Bocca","year":"1998","unstructured":"Bocca AL, Hayashi EE, Pinheiro AG, Furlanetto AB, Campanelli AP, Cunha FQ, Figueiredo F. Treatment of Paracoccidioides brasiliensis-infected mice with a nitric oxide inhibitor prevents the failure of cell-mediated immune response. J Immunol. 1998;161:3056\u201363.","journal-title":"J Immunol"}],"container-title":["Mycopathologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-012-9599-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11046-012-9599-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-012-9599-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T23:30:00Z","timestamp":1687822200000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11046-012-9599-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,22]]},"references-count":47,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["9599"],"URL":"https:\/\/doi.org\/10.1007\/s11046-012-9599-7","relation":{},"ISSN":["0301-486X","1573-0832"],"issn-type":[{"value":"0301-486X","type":"print"},{"value":"1573-0832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,22]]}}}