{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:18:57Z","timestamp":1791839937061,"version":"4.3.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T00:00:00Z","timestamp":1418083200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mycopathologia"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1007\/s11046-014-9815-8","type":"journal-article","created":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T13:44:30Z","timestamp":1418046270000},"page":"31-43","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Immunization with Recombinant Pb27 Protein Reduces the Levels of Pulmonary Fibrosis Caused by the Inflammatory Response Against Paracoccidioides brasiliensis"],"prefix":"10.1007","volume":"179","author":[{"given":"Elis Araujo","family":"Morais","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estef\u00e2nia Mara do Nascimento","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jankerle Neves","family":"Boelone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawidson Assis","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo Miranda","family":"Goes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,12,9]]},"reference":[{"key":"9815_CR1","volume-title":"Treaty of medical mycology","author":"CS Lacaz","year":"2002","unstructured":"Lacaz CS, Porto E, Martins JEC, Heinz-Vaccari EM, Melo NT. Treaty of medical mycology. 8th ed. S\u00e3o Paulo: Sarvier; 2002.","edition":"8"},{"key":"9815_CR2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ympev.2009.04.005","volume":"52","author":"MM Teixeira","year":"2009","unstructured":"Teixeira MM, Theodoro RC, de Carvalho MJ, Fernandes L, Paes HC, Hahn RC, Mendoza L, Bagagli E, San-Blas G, Felipe MS. Phylogenetic analysis reveals a high level of speciation in the Paracoccidioides genus. Mol Phylogenet Evol. 2009;52:273\u201383.","journal-title":"Mol Phylogenet Evol"},{"key":"9815_CR3","doi-asserted-by":"crossref","unstructured":"Brummer E, Castaneda E, Restrepo A. Paracoccidioidomycosis: an update. Clin Microbiol Rev. 1993;6:89\u2013117. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8472249 .","DOI":"10.1128\/CMR.6.2.89"},{"key":"9815_CR4","doi-asserted-by":"crossref","unstructured":"Wanhe B, Aide MA. Chapter 6\u2014paracoccidioidomycosis. Bras J Pneumol. 2009; 1245\u20131249. http:\/\/dx.doi.org\/10.1590\/S1806-37132009001200013 .","DOI":"10.1590\/S1806-37132009001200013"},{"key":"9815_CR5","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1128\/CVI.00239-06","volume":"13","author":"SH Marques-da-Silva","year":"2006","unstructured":"Marques-da-Silva SH, Colombo AL, Blotta MH, Queiroz-Telles F, Balthazar AB, et al. Diagnosis of paracoccidioidomycosis by detection of antigen and antibody in bronchoalveolar lavage fluids. Clin Vaccine Immunol. 2006;13:1363\u20136.","journal-title":"Clin Vaccine Immunol"},{"key":"9815_CR6","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1128\/CVI.00285-06","volume":"14","author":"S Bertini","year":"2007","unstructured":"Bertini S, Colombo AL, Takahashi HK, Straus AH. Expression of antibodiesndirected to Paracoccidioides brasiliensis glycosphingolipids during the course of paracoccidioidomycosis treatment. Clin Vaccine Immunol. 2007;14:150\u20136.","journal-title":"Clin Vaccine Immunol"},{"key":"9815_CR7","first-page":"41","volume":"17","author":"ZP Camargo","year":"2000","unstructured":"Camargo ZP, Franco MF. Current knowledge on pathogenesis and immunodiagnosis of paracoccidioidomycosis. Rev Iberoam Micol. 2000;17:41\u20138.","journal-title":"Rev Iberoam Micol"},{"key":"9815_CR8","doi-asserted-by":"crossref","first-page":"798","DOI":"10.4269\/ajtmh.2009.80.798","volume":"80","author":"FC Silva Da","year":"2009","unstructured":"Da Silva FC, Svidzinski TI, Patussi EV, Cardoso CP, De Oliveira Dalalio MM, Hernandes L. Morphologic organization of pulmonary granulomas in mice infected with Paracoccidioides brasiliensis. Am J Trop Med Hyg. 2009;80:798\u2013804.","journal-title":"Am J Trop Med Hyg"},{"key":"9815_CR9","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1590\/S0037-86822006000300017","volume":"39","author":"MA Shikanai-Yasuda","year":"2006","unstructured":"Shikanai-Yasuda MA, Telles FFQ, Mendes RP, Colombo AL, Moretti ML. Guidelines in paracoccidioidomycosis. Rev Soc Bras Med Trop. 2006;39:297\u2013310.","journal-title":"Rev Soc Bras Med Trop"},{"key":"9815_CR10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/mi.2008.85","volume":"2","author":"M Wilson","year":"2009","unstructured":"Wilson M, Wynn T. Pulmonary fibrosis: pathogenesis, etiology and regulation. Mucosal Immunol. 2009;2:103\u201321.","journal-title":"Mucosal Immunol"},{"key":"9815_CR11","doi-asserted-by":"crossref","first-page":"424","DOI":"10.4269\/ajtmh.1998.58.424","volume":"58","author":"L Franco","year":"1998","unstructured":"Franco L, Najvar L, Gomez BL, Restrepo S, Graybill JR, et al. Experimental pulmonary fibrosis induced by Paracoccidioides brasiliensis conidia: measurement of local host responses. Am J Trop Med Hyg. 1998;58:424\u201330.","journal-title":"Am J Trop Med Hyg"},{"key":"9815_CR12","doi-asserted-by":"crossref","first-page":"798","DOI":"10.4269\/ajtmh.2009.80.798","volume":"80","author":"FCD Silva","year":"2009","unstructured":"Silva FCD, Svidzinski TIE, Patussi EV, Cardoso CP, Dalalio MMDO, et al. Morphologic organization of pulmonary granulomas in mice infected with Paracoccidioides brasiliensis. Am J Trop Med Hyg. 2009;80:798\u2013804.","journal-title":"Am J Trop Med Hyg"},{"key":"9815_CR13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1590\/S0036-46652000000200001","volume":"42","author":"AM Cock","year":"2000","unstructured":"Cock AM, Cano LE, Velez D, Aristizabal BH, Trujillo J, et al. Fibrotic sequelae in pulmonary paracoccidioidomycosis: histopathological aspects in BALB\/c mice infected with viable and non-viable Paracoccidioides brasiliensis propagules. Rev Inst Med Trop Sao Paulo. 2000;42:59\u201366.","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"9815_CR14","doi-asserted-by":"crossref","first-page":"5461","DOI":"10.1016\/j.vaccine.2008.07.097","volume":"26","author":"BS Reis","year":"2008","unstructured":"Reis BS, Fernandes VC, Martins EM, Serakides R, Goes AM. Protective immunity induced by rPb27 of Paracoccidioides brasiliensis. Vaccine. 2008;26:5461\u20139.","journal-title":"Vaccine"},{"key":"9815_CR15","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jim.2011.02.006","volume":"367","author":"VC Fernandes","year":"2011","unstructured":"Fernandes VC, Coitinho JB, Veloso JM, Araujo SA, Pedroso EP, et al. Combined use of Paracoccidioides brasiliensis recombinant rPb27 and rPb40 antigens in an enzyme-linked immunosorbent assay for immunodiagnosis of paracoccidioidomycosis. J Immunol Methods. 2011;367:78\u201384.","journal-title":"J Immunol Methods"},{"key":"9815_CR16","unstructured":"Morais EA, Martins EMN, Fernandes CV, Santos IGD dos, Silva GAB, et al. Immunization with rPb27 protects mice from the disruption of VEGF signaling in Paracoccidioides brasiliensis infection. J Life Sci 2013;7:913\u2013927. http:\/\/www.davidpublishing.com\/show.html?15014 ."},{"issue":"3","key":"9815_CR17","doi-asserted-by":"crossref","first-page":"e17885","DOI":"10.1371\/journal.pone.0017885","volume":"6","author":"VC Fernandes","year":"2011","unstructured":"Fernandes VC, Martins EM, Boeloni JN, Coitinho JB, Serakides R, et al. Additive effect of rPb27 immunization and chemotherapy in experimental Paracoccidioidomycosis. PLoS One. 2011;6(3):e17885.","journal-title":"PLoS One"},{"key":"9815_CR18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0074-02762012000100001","volume":"107","author":"LS Santos","year":"2012","unstructured":"Santos LS, Fernandes VC, Cruz SG, Siqueira WC, Goes AM, et al. Profile of total IgG, IgG1, IgG2, IgG3 and IgG4 levels in sera of patients with paracoccidioidomycosis: treatment follow-up using Mexo and rPb27 as antigens in an ELISA. Mem Inst Oswaldo Cruz. 2012;107:1\u201310.","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"9815_CR19","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1006\/meth.2001.1261","volume":"25","author":"A Giulietti","year":"2001","unstructured":"Giulietti A, Overbergh L, Valckx D, Decallonne B, Bouillon R, et al. An overview of real-time quantitative PCR: applications to quantify cytokine gene expression. Methods. 2001;25:386\u2013401.","journal-title":"Methods"},{"key":"9815_CR20","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1590\/S0037-86822010000400034","volume":"43","author":"R Martinez","year":"2010","unstructured":"Martinez R. Paracoccidioidomycosis: the dimension of the problem of a neglected disease. Rev Soc Bras Med Trop. 2010;43:480.","journal-title":"Rev Soc Bras Med Trop"},{"key":"9815_CR21","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1021\/bk-2012-1115.ch022","volume-title":"Galectins and disease implications for targeted therapeutics","author":"NC Henderson","year":"2012","unstructured":"Henderson NC, Mackinnon AC, Rooney C, Sethi T. Galectin-3: A central regulator of chronic inflammation and tissue fibrosis. In: Klyosov AA, Traber PG, editors. Galectins and disease implications for targeted therapeutics. Washington, DC: American Chemical Society; 2012. p. 377\u201390."},{"key":"9815_CR22","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/S1359-6446(03)02864-2","volume":"15","author":"DJ Marciani","year":"2003","unstructured":"Marciani DJ. Vaccine adjuvants: role and mechanisms of action in vaccine immunogenicity. Drug Discov Today. 2003;15:934\u201343.","journal-title":"Drug Discov Today"},{"key":"9815_CR23","author":"O Mayorga","year":"2012","unstructured":"Mayorga O, Mu\u00f1oz JE, Lincopan N, Teixeira AF, Ferreira LC, et al. The role of adjuvants in therapeutic protection against paracoccidioidomycosis after immunization with the P10 peptide. Front Microbiol. 2012. doi: 10.3389\/fmicb.2012.00154 .","journal-title":"Front Microbiol"},{"key":"9815_CR24","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1590\/S0037-86822005000600013","volume":"38","author":"ZA Andrade","year":"2005","unstructured":"Andrade ZA. Regression of hepatic fibrosis. Rev Soc Bras Med Trop. 2005;38:514\u201320.","journal-title":"Rev Soc Bras Med Trop"},{"key":"9815_CR25","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.2807","volume":"18","author":"TA Wynn","year":"2002","unstructured":"Wynn TA, Ramalingam TR. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med. 2002;18:1028\u201340.","journal-title":"Nat Med"},{"key":"9815_CR26","author":"H David","year":"2014","unstructured":"David H, Cory H. Heterogeneity in fibroblast proliferation and survival in idiopathic pulmonary fibrosis. Front Pharmacol. 2014;. doi: 10.3389\/fphar.2014.00002 .","journal-title":"Front Pharmacol"},{"key":"9815_CR27","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1159\/000207617","volume":"78","author":"H Shinoda","year":"2009","unstructured":"Shinoda H, Tasaka S, Fujishima S, Yamasawa W, Miyamoto K, et al. Elevated CC chemokine level in bronchoalveolar lavage fluid is predictive of a poor outcome of idiopathic pulmonary fibrosis. Respiration. 2009;78:285\u201392.","journal-title":"Respiration"},{"key":"9815_CR28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1293\/tox.24.9","volume":"24","author":"T Yoshida","year":"2011","unstructured":"Yoshida T, Ohnuma A, Horiuchi H, Harada T. Pulmonary fibrosis in response to environmental cues and molecular targets involved in its pathogenesis. J Toxicol Pathol. 2011;24:9\u201324.","journal-title":"J Toxicol Pathol"},{"key":"9815_CR29","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1136\/jcp.2005.026872","volume":"59","author":"ES Choi","year":"2006","unstructured":"Choi ES, Pierce EM, Jakubzick C, Carpenter KJ, Kunkel SL, et al. Focal interstitial CC chemokine receptor 7 (CCR7) expression in idiopathic interstitial pneumonia. J Clin Pathol. 2006;59:28\u201339.","journal-title":"J Clin Pathol"},{"key":"9815_CR30","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1183\/09031936.00122806","volume":"29","author":"EM Pierce","year":"2007","unstructured":"Pierce EM, Carpenter K, Jakubzick C, Kunkel SL, Evanoff H, et al. Idiopathic pulmonary fibrosis fibroblasts migrate and proliferate to CC chemokine ligand 21. Eur Respir J. 2007;29:1082\u201393.","journal-title":"Eur Respir J"},{"key":"9815_CR31","author":"G Trujillo","year":"2010","unstructured":"Trujillo G, Hartigan AJ, Hogaboam CM. T regulatory cells and attenuated bleomycin-induced fibrosis in lungs of CCR7\u2212\/\u2212 mice. Fibrogenesis Tissue Repair. 2010;. doi: 10.1186\/1755-1536-3-18 .","journal-title":"Fibrogenesis Tissue Repair"},{"key":"9815_CR32","doi-asserted-by":"crossref","unstructured":"Grivicich I, Regner A, Rocha AB. Apoptosis: programmed cell death. Revista Brasileira de Cancerologia 2007;53:335\u2013343. http:\/\/www.inca.gov.br\/rbc\/n_53\/v03\/pdf\/revisao4.pdf .","DOI":"10.32635\/2176-9745.RBC.2007v53n3.1801"},{"key":"9815_CR33","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1590\/S0004-28032001000200011","volume":"38","author":"MB Parolin","year":"2001","unstructured":"Parolin MB, Reason JM. Apoptosis as a mechanism of tissue injury in hepatobiliary diseases. Arq Gastroenterol. 2001;38:138\u201344.","journal-title":"Arq Gastroenterol"},{"key":"9815_CR34","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1016\/j.micinf.2006.08.012","volume":"8","author":"MA Ver\u00edcimo","year":"2006","unstructured":"Ver\u00edcimo MA, Fran\u00e7a KM, Arnholdt AC, Kipnis TL. Increased apoptosis during the early phase of experimental paracoccidioidomycosis as a phenotypic marker of resistance. Microbes Infect. 2006;8:2811\u201320.","journal-title":"Microbes Infect"},{"key":"9815_CR35","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1378\/chest.120.1_suppl.S5","volume":"120","author":"NW Lukacs","year":"2001","unstructured":"Lukacs NW, Hogaboam C, Chensue SW, Blease K. Kunkel SL Type 1\/type 2 cytokine paradigm and the progression of pulmonary fibrosis. Chest. 2001;120:5S\u20138S.","journal-title":"Chest"},{"key":"9815_CR36","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1378\/chest.97.6.1439","volume":"97","author":"JA Elias","year":"1990","unstructured":"Elias JA, Freundlich B, Kern JA, Rosenbloom J. Cytokine networks in the regulation of inflammation and fibrosis in the lung. Chest. 1990;97:1439\u201345.","journal-title":"Chest"},{"key":"9815_CR37","doi-asserted-by":"crossref","unstructured":"Atamas SP, Chapoval SP, Keegan AD. Cytokines in chronic respiratory diseases. F1000 Biol Rep 2013. doi: 10.3410\/B5-3 .","DOI":"10.3410\/B5-3"},{"key":"9815_CR38","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1128\/IAI.56.7.1771-1777.1988","volume":"56","author":"E Castaneda","year":"1988","unstructured":"Castaneda E, Brummer E, Pappagianis D, Stevens DA. Impairment of cellular but not humoral immune responses in chronic pulmonary and disseminated paracoccidioidomycosis in mice. Infect Immun. 1988;56:1771\u20137.","journal-title":"Infect Immun"},{"key":"9815_CR39","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1128\/IAI.63.5.1777-1783.1995","volume":"63","author":"LE Cano","year":"1995","unstructured":"Cano LE, Singer-Vermes LM, Vaz CA, Russo M, Calich VL. Pulmonary paracoccidioidomycosis in resistant and susceptible mice: relationship among progression of infection, bronchoalveolar cell activation, cellular immune response, and specific isotype patterns. Infect Immun. 1995;63:1777\u201383.","journal-title":"Infect Immun"},{"key":"9815_CR40","first-page":"139","volume":"71","author":"M Denis","year":"1990","unstructured":"Denis M, Gregg EO. Recombinant tumour necrosis factor-alpha decreases whereas recombinant interleukin-6 increases growth of a virulent strain of Mycobacterium avium in human macrophages. Immunology. 1990;71:139\u201341.","journal-title":"Immunology"},{"key":"9815_CR41","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.1128\/IAI.62.9.3980-3983.1994","volume":"62","author":"DP Dooley","year":"1994","unstructured":"Dooley DP, Cox RA, Hestilow KL, Dolan MJ, Magee DM. Cytokine induction in human coccidioidomycosis. Infect Immun. 1994;62:3980\u20133.","journal-title":"Infect Immun"},{"key":"9815_CR42","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/13693780802244204","volume":"47","author":"KZ Siqueira","year":"2009","unstructured":"Siqueira KZ, Soares AMC, Dias-Melicio LA, Calvi SA, Peracoli MT. Interleukin-6 treatment enhances human monocyte permissiveness for Paracoccidioides brasiliensis growth by modulating cytokine production. Med Mycol. 2009;47:259\u201367.","journal-title":"Med Mycol"},{"key":"9815_CR43","unstructured":"Abbas AK, LIchtman AH. Cellular and molecular Immunology. 5th ed. Rio de Janeiro: Elsevier; 2005."},{"key":"9815_CR44","unstructured":"Pinzan CF, Ruas LP, Casabona-Fortunato AS, Carvalho FC, Roque-Barreira MC. Immunological basis for the gender differences in murine Paracoccidioides brasiliensis infection. PLoS One. 2010. doi: 10.1371\/0010757 ."},{"key":"9815_CR45","doi-asserted-by":"crossref","first-page":"e15935","DOI":"10.1371\/journal.pone.0015935","volume":"6","author":"KS Ferreira","year":"2011","unstructured":"Ferreira KS, Maranhao AQ, Garcia MC, Brigido MM, Santos SS, et al. Dendritic cells transfected with scFv from Mab 7. B12 mimicking original antigen gp43 induces protection against experimental Paracoccidioidomycosis. PLoS One. 2011;6:e15935.","journal-title":"PLoS One"}],"container-title":["Mycopathologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-014-9815-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11046-014-9815-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-014-9815-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T00:54:38Z","timestamp":1650761678000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11046-014-9815-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,9]]},"references-count":45,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["9815"],"URL":"https:\/\/doi.org\/10.1007\/s11046-014-9815-8","relation":{},"ISSN":["0301-486X","1573-0832"],"issn-type":[{"value":"0301-486X","type":"print"},{"value":"1573-0832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,9]]}}}