{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:09:35Z","timestamp":1778540975188,"version":"3.51.4"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"3-4","license":[{"start":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T00:00:00Z","timestamp":1418342400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mycopathologia"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1007\/s11046-014-9832-7","type":"journal-article","created":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T14:58:11Z","timestamp":1418309891000},"page":"231-242","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["1,10-Phenanthroline Inhibits the Metallopeptidase Secreted by Phialophora verrucosa and Modulates its Growth, Morphology and Differentiation"],"prefix":"10.1007","volume":"179","author":[{"given":"Marcela Queiroz","family":"Granato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila","family":"de Ara\u00fajo Massapust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Rozental","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celuta Sales","family":"Alviano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Luis Souza","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucimar Ferreira","family":"Kneipp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,12,12]]},"reference":[{"key":"9832_CR1","unstructured":"Rippon JW. Chromoblastomycosis. In: Medical mycology: the pathogenic fungi and the pathogenic actinomycetes. WB Saunders: Philadelphia; 1988. p. 276\u201396."},{"key":"9832_CR2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/13693780802538001","volume":"47","author":"F Queiroz-Telles","year":"2009","unstructured":"Queiroz-Telles F, Esterre P, Perez-Blanco M. Chromoblastomycosis: an overview of clinical manifestations, diagnosis and treatment. Med Mycol. 2009;47:3\u201315.","journal-title":"Med Mycol"},{"key":"9832_CR3","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.1574-6976.2007.00077.x","volume":"31","author":"ALS Santos","year":"2007","unstructured":"Santos ALS, Palmeira VF, Rozental S, Kneipp LF, Nimrichter L, Alviano DS, Rodrigues ML, Alviano CS. Biology and pathogenesis of Fonsecaea pedrosoi, the major etiologic agent of chromoblastomycosis. FEMS Microbiol Rev. 2007;31:570\u201391.","journal-title":"FEMS Microbiol Rev"},{"key":"9832_CR4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1258\/td.2009.090264","volume":"40","author":"M Ameen","year":"2010","unstructured":"Ameen M. Managing chromoblastomycosis. Trop Doct. 2010;40:65\u20137.","journal-title":"Trop Doct"},{"key":"9832_CR5","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s11046-013-9626-3","volume":"175","author":"Z Tong","year":"2013","unstructured":"Tong Z, Chen SC, Chen L, Dong B, Li R, Hu Z, Jiang P, Li D, Duan Y. Generalized subcutaneous phaeohyphomycosis caused by Phialophora verrucosa: report of a case and review of literature. Mycopathologia. 2013;175:301\u20136.","journal-title":"Mycopathologia"},{"key":"9832_CR6","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0190-9622(95)90393-3","volume":"32","author":"GW Turiansky","year":"1995","unstructured":"Turiansky GW, Benson PM, Sperling LC, Sperling LC, Sau P, Salkin IF, McGinnis MR, James WD. Phialophora verrucosa: a new cause of mycetoma. J Am Acad Dermatol. 1995;32:311\u20135.","journal-title":"J Am Acad Dermatol"},{"key":"9832_CR7","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/sj.bmt.1700969","volume":"20","author":"TS Lundstrom","year":"1997","unstructured":"Lundstrom TS, Fairfaz MR, Dugan MC, Vazquez JA, Chandrasekar PH, Abella E, Kasten-Sportes C. Case report Phialophora verrucosa infection in a BMT patient. Bone Marrow Transplant. 1997;20:789\u201391.","journal-title":"Bone Marrow Transplant"},{"key":"9832_CR8","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.eimc.2011.10.012","volume":"30","author":"MI Campos-Herrero","year":"2012","unstructured":"Campos-Herrero MI, Tand\u00f3n L, Horcajada I, Medina-Rivero F. Endophthalmitis caused by Phialophora verrucosa: a case report and literature review of Phialophora ocular infections. Enferm Infecc Microbiol Clin. 2012;30:163\u20135.","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"9832_CR9","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.2174\/092986711795843182","volume":"18","author":"LA Braga-Silva","year":"2011","unstructured":"Braga-Silva LA, Santos ALS. Aspartic protease inhibitors as potential anti-Candida albicans drugs: impacts on fungal biology, virulence and pathogenesis. Curr Med Chem. 2011;18:2401\u201319.","journal-title":"Curr Med Chem"},{"key":"9832_CR10","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1078\/1438-4221-00223","volume":"292","author":"M Monod","year":"2002","unstructured":"Monod M, Capoccia S, L\u00e9chenne B. Secreted proteases from pathogenic fungi. Int J Med Microbiol. 2002;292:405\u201319.","journal-title":"Int J Med Microbiol"},{"issue":"67","key":"9832_CR11","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1128\/MMBR.67.3.400-428.2003","volume":"2003","author":"JR Naglik","year":"2003","unstructured":"Naglik JR, Challacombr SJ, Hube B. Candida albicans aspartyl proteinase in virulence and pathogenesis. Microbiol Mol Biol Rev. 2003;2003(67):400\u201328.","journal-title":"Microbiol Mol Biol Rev"},{"key":"9832_CR12","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4331\/wjbc.v2.i3.48","volume":"26","author":"ALS Santos","year":"2011","unstructured":"Santos ALS. Protease expression by microorganisms and its relevance to crucial physiological\/pathological events. World J Biol Chem. 2011;26:48\u201358.","journal-title":"World J Biol Chem"},{"key":"9832_CR13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s00284-005-0156-1","volume":"53","author":"BA Silva","year":"2006","unstructured":"Silva BA, Santos ALS, Barreto-Bergter E, Pinto MR. Extracellular peptidase in the fungal pathogen Pseudallescheria boydii. Curr Microbiol. 2006;53:18\u201322.","journal-title":"Curr Microbiol"},{"key":"9832_CR14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1574-695X.2005.00003.x","volume":"46","author":"VF Palmeira","year":"2006","unstructured":"Palmeira VF, Kneipp LF, Alviano CS, Santos ALS. The major chromoblastomycosis fungal pathogen, Fonsecaea pedrosoi, extracellularly releases proteolytic enzymes whose expression is modulated by culture medium composition: implications on the fungal development and cleavage of key\u2019s host structures. FEMS Immunol Med Microbiol. 2006;46:21\u20139.","journal-title":"FEMS Immunol Med Microbiol"},{"key":"9832_CR15","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.resmic.2006.07.003","volume":"157","author":"VF Palmeira","year":"2006","unstructured":"Palmeira VF, Kneipp LF, Alviano CS, Santos ALS. Secretory aspartyl peptidase activity from mycelia of the human fungal pathogen Fonsecaea pedrosoi: effect of HIV aspartyl proteolytic inhibitors. Res Microbiol. 2006;157:819\u201326.","journal-title":"Res Microbiol"},{"key":"9832_CR16","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1371\/journal.pone.0003382","volume":"3","author":"VF Palmeira","year":"2008","unstructured":"Palmeira VF, Kneipp LF, Rozental S, Alviano CS, Santos ALS. Beneficial effects of HIV peptidase inhibitors on Fonsecaea pedrosoi: promising compounds to arrest key fungal biological processes and virulence. PLoS One. 2008;3:3382.","journal-title":"PLoS One"},{"key":"9832_CR17","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1006\/abio.1993.1066","volume":"208","author":"M Buroker-Kilgore","year":"1993","unstructured":"Buroker-Kilgore M, Wang KKA. Coomassie brilliant blue G-250-based colorimetric assay for measuring activity of calpain and other proteases. Anal Biochem. 1993;208:387\u201392.","journal-title":"Anal Biochem"},{"key":"9832_CR18","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"UK Laemmli","year":"1970","unstructured":"Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680\u20135.","journal-title":"Nature"},{"key":"9832_CR19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/elps.1150080203","volume":"8","author":"H Blum","year":"1987","unstructured":"Blum H, Beier H, Gross HJ. Improved silver staining of plant proteins, RNA and DNA polyacrylamide gels. Eletrophoresis. 1987;8:93\u20139.","journal-title":"Eletrophoresis"},{"key":"9832_CR20","unstructured":"CLSI. Clinical Laboratory Standards Institute. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi: second edition (M38-A2). Wayne: CLSI; 2008."},{"key":"9832_CR21","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jep.2006.12.005","volume":"111","author":"MCS Cruz","year":"2007","unstructured":"Cruz MCS, Santos PO, Barbosa AM Jr, Melo DLFM, Alviano CS, Antoniolli AR, Alviano DS, Trindade RC. Antifungal activity of Brazilian medicinal plants involved in popular treatment of mycoses. J Ethnopharmacol. 2007;111:409\u201312.","journal-title":"J Ethnopharmacol"},{"key":"9832_CR22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/13693780802566333","volume":"47","author":"RG Vitale","year":"2009","unstructured":"Vitale RG, Perez-Blanco M, De Hoog GS. In vitro activity of antifungal drugs against Cladophialophora species associated with human chromoblastomycosis. Med Mycol. 2009;47:35\u201340.","journal-title":"Med Mycol"},{"key":"9832_CR23","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1128\/CMR.17.2.268-280.2004","volume":"17","author":"MA Pfaller","year":"2004","unstructured":"Pfaller MA, Sheehan DJ, Rex JH. Determination of fungicidal activities against yeasts and molds: lessons learned from bactericidal testing and the need for standardization. Clin Microbiol Rev. 2004;17:268\u201380.","journal-title":"Clin Microbiol Rev"},{"key":"9832_CR24","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1590\/S0074-02762012000500003","volume":"107","author":"CR Guerra","year":"2012","unstructured":"Guerra CR, Ishida K, Nucci M, Rozental S. Terbinafine inhibits Cryptococcus neoformans growth and modulates fungal morphology. Mem Inst Oswaldo Cruz. 2012;107:582\u201390.","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"9832_CR25","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nature10947","volume":"484","author":"MC Fisher","year":"2012","unstructured":"Fisher MC, Henk DA, Briggs CJ, Brownstein JS, Madoff LC, McCraw SL, Gurr SJ. Emerging fungal threats to animal, plant and ecosystem health. Nature. 2012;484:186\u201394.","journal-title":"Nature"},{"key":"9832_CR26","unstructured":"Revankar SG, Sutton DA. Melanized fungi in human disease. Clin Microbiol Rev. 2010;23:884\u2013928. Erratum in: Clin Microbiol Rev. 2012;25:720."},{"key":"9832_CR27","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1258\/td.2008.080151","volume":"39","author":"M Ameen","year":"2009","unstructured":"Ameen M. Managing mycetomas. Trop Doct. 2009;39:66\u20138.","journal-title":"Trop Doct"},{"key":"9832_CR28","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1590\/S0074-02762012000700003","volume":"107","author":"CB Severo","year":"2012","unstructured":"Severo CB, Oliveira FM, Pilar EF, Severo LC. Phaeohyphomycosis: a clinical\u2013epidemiological and diagnostic study of eighteen cases in Rio Grande do Sul, Brazil. Mem Inst Oswaldo Cruz. 2012;107:854\u20138.","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"9832_CR29","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3109\/13693786.2011.653835","volume":"50","author":"LF Kneipp","year":"2012","unstructured":"Kneipp LF, Magalh\u00e3es AS, Abi-Chacra EA, Souza LO, Alviano CS, Santos AL, Meyer-Fernandes JR. Surface phosphatase in Rhinocladiella aquaspersa: biochemical properties and its involvement with adhesion. Med Mycol. 2012;50:570\u20138.","journal-title":"Med Mycol"},{"key":"9832_CR30","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1128\/EC.3.1.40-51.2004","volume":"3","author":"H Liu","year":"2004","unstructured":"Liu H, Kauffman S, Becker JM, Szaniszlo PJ. Wangiella (Exophiala) dermatitidis WdChs5p, a class V chitin synthase, is essential for sustained cell growth at temperature of infection. Eukaryot Cell. 2004;3:40\u201351.","journal-title":"Eukaryot Cell"},{"key":"9832_CR31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S1367-5931(03)00033-4","volume":"7","author":"RC Holz","year":"2003","unstructured":"Holz RC, Bzymek KP, Swierczek SI. Co-catalytic metallopeptidases as pharmaceutical targets. Curr Opin Chem Biol. 2003;7:197\u2013206.","journal-title":"Curr Opin Chem Biol"},{"key":"9832_CR32","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.resmic.2005.11.010","volume":"157","author":"BA Silva","year":"2006","unstructured":"Silva BA, Pinto MR, Soares RMA, Barreto-Bergter E, Santos ALS. Pseudallescheria boydii releases metallopeptidases capable of cleaving several proteinaceous compounds. Res Microbiol. 2006;157:425\u201332.","journal-title":"Res Microbiol"},{"key":"9832_CR33","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1439-0507.2009.01767.x","volume":"54","author":"BA Silva","year":"2009","unstructured":"Silva BA, Souza-Gon\u00e7alves AL, Pinto MR, Barreto-Bergter E, Santos ALS. Metallopeptidase inhibitors arrest vital biological processes in the fungal pathogen Scedosporium apiospermum. Mycoses. 2009;54:105\u201312.","journal-title":"Mycoses"},{"key":"9832_CR34","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3109\/13693786.2011.590825","volume":"50","author":"ET Gravi","year":"2012","unstructured":"Gravi ET, Paschoalin T, Dias BR, Moreira DF, Belizario JE, Oliveira V, Carmona AK, Juliano MA, Travassos LR, Rodrigues EG. Identification of a metallopeptidase with TOP-like activity in Paracoccidioides brasiliensis, with increased expression in a virulent strain. Med Mycol. 2012;50:81\u201390.","journal-title":"Med Mycol"},{"key":"9832_CR35","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.2174\/092986712800609733","volume":"19","author":"M McCann","year":"2012","unstructured":"McCann M, Kellett AM, Kavanagh K, Devereux M, Santos ALS. Deciphering the antimicrobial activity of phenanthroline chelators. Curr Med Chem. 2012;19:2703\u201314.","journal-title":"Curr Med Chem"},{"key":"9832_CR36","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1039\/cs9942300327","volume":"23","author":"PG Sammes","year":"1994","unstructured":"Sammes PG, Yahioglu GY. 1,10-Phenanthroline: a versatile ligand. Chem Soc Rev. 1994;23:327\u201334.","journal-title":"Chem Soc Rev"},{"key":"9832_CR37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-5793(94)01079-X","volume":"354","author":"NM Hooper","year":"1994","unstructured":"Hooper NM. Families of zinc metalloproteases. FEBS Lett. 1994;354:1\u20136.","journal-title":"FEBS Lett"},{"key":"9832_CR38","doi-asserted-by":"crossref","first-page":"5647","DOI":"10.1021\/bi00476a001","volume":"29","author":"BL Valle","year":"1990","unstructured":"Valle BL, Auld DS. Zinc coordination, function, and structure of zinc enzymes and other proteins. Biochemistry. 1990;29:5647\u201359.","journal-title":"Biochemistry"},{"key":"9832_CR39","first-page":"267","volume":"35","author":"S Brul","year":"1997","unstructured":"Brul S, Stratford M, Van der Vaart JM, Dielbandhoesing SK, Steels H, Klis FM, Verrips CT. The antifungal action of 1,10-phenanthroline and EDTA is mediated through zinc chelation and involves cell wall construction. Food Technol Biotech. 1997;35:267\u201374.","journal-title":"Food Technol Biotech"},{"key":"9832_CR40","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1111\/j.1574-6976.2012.00340.x","volume":"36","author":"B Singh","year":"2012","unstructured":"Singh B, Fleury C, Jalalvand F, Riesbeck K. Human pathogens utilize host extracellular matrix proteins laminin and collagen for adhesion and invasion of the host. FEMS Microbiol Rev. 2012;36:1122\u201380.","journal-title":"FEMS Microbiol Rev"},{"key":"9832_CR41","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s11046-010-9386-2","volume":"171","author":"I Yike","year":"2011","unstructured":"Yike I. Fungal proteases and their pathophysiological effects. Mycopathology. 2011;171:299\u2013323.","journal-title":"Mycopathology"},{"key":"9832_CR42","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.2174\/092986712800609788","volume":"19","author":"ALS Santos","year":"2012","unstructured":"Santos ALS, Sodr\u00e9 CL, Valle RS, Silva BA, Abi-Chacra EA, Silva LV, Souza-Goncalves AL, Sangenito LS, Goncalves DS, Souza LO, Palmeira VF, d\u2019Avila-Levy CM, Kneipp LF, Kellett A, McCann M, Branquinha MH. Antimicrobial action of chelating agents: repercussions on the microorganism development, virulence and pathogenesis. Curr Med Chem. 2012;19:2715\u201337.","journal-title":"Curr Med Chem"},{"key":"9832_CR43","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1155\/MBD.2000.185","volume":"7","author":"M McCann","year":"2000","unstructured":"McCann M, Geraghty M, Devereux M, Devereux M, O\u2019Shea D, Mason J, O\u2019Sullivan L. Insights into the mode of action of the anti-Candida activity of 1,10-phenanthroline and its metal chelates. Met Based Drugs. 2000;7:185\u201393.","journal-title":"Met Based Drugs"},{"key":"9832_CR44","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1586\/eri.11.152","volume":"10","author":"ID Jacobsen","year":"2012","unstructured":"Jacobsen ID, Wilson D, W\u00e4chtler B, Brunke S, Naglik JR, Hube B. Candida albicans dimorphism as a therapeutic target. Expert Rev Anti Infect Ther. 2012;10:85\u201393.","journal-title":"Expert Rev Anti Infect Ther"}],"container-title":["Mycopathologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-014-9832-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11046-014-9832-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-014-9832-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T03:45:55Z","timestamp":1559360755000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11046-014-9832-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,12]]},"references-count":44,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["9832"],"URL":"https:\/\/doi.org\/10.1007\/s11046-014-9832-7","relation":{},"ISSN":["0301-486X","1573-0832"],"issn-type":[{"value":"0301-486X","type":"print"},{"value":"1573-0832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,12]]}}}