{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T05:39:30Z","timestamp":1776058770243,"version":"3.50.1"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T00:00:00Z","timestamp":1519948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R21AI85566-01"],"award-info":[{"award-number":["1R21AI85566-01"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mycopathologia"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s11046-018-0254-9","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T14:16:29Z","timestamp":1520000189000},"page":"645-658","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["RNA-Seq Profile Reveals Th-1 and Th-17-Type of Immune Responses in Mice Infected Systemically with Aspergillus fumigatus"],"prefix":"10.1007","volume":"183","author":[{"given":"Jata","family":"Shankar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo C.","family":"Cerqueira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer R.","family":"Wortman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl V.","family":"Clemons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,3,2]]},"reference":[{"issue":"3","key":"254_CR1","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S0732-8893(99)00026-7","volume":"34","author":"MF VandenBergh","year":"1999","unstructured":"VandenBergh MF, Verweij PE, Voss A. Epidemiology of nosocomial fungal infections: invasive aspergillosis and the environment. Diagn Microbiol Infect Dis. 1999;34(3):221\u20137. https:\/\/doi.org\/10.1016\/S0732-8893(99)00026-7 .","journal-title":"Diagn Microbiol Infect Dis"},{"key":"254_CR2","doi-asserted-by":"publisher","unstructured":"Walsh TJ, Stevens DA. Aspergillosis. In: Goldman L, Schafer AI, editors. Goldman\u2019s cecil medicine. 24th ed., vol 2. Elsevier; 2011. p. 1990\u20131994. https:\/\/doi.org\/10.1016\/B978-1-4377-1604-7.00347-X .","DOI":"10.1016\/B978-1-4377-1604-7.00347-X"},{"issue":"4","key":"254_CR3","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/S0891-5520(02)00035-1","volume":"16","author":"KA Marr","year":"2002","unstructured":"Marr KA, Patterson T, Denning D. Aspergillosis: pathogenesis, clinical manifestations, and therapy. Infect Dis Clin North Am. 2002;16(4):875\u201394.","journal-title":"Infect Dis Clin North Am"},{"issue":"4","key":"254_CR4","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1128\/CMR.00014-09","volume":"22","author":"SJ Park","year":"2009","unstructured":"Park SJ, Mehrad B. Innate immunity to Aspergillus species. Clin Microbiol Rev. 2009;22(4):535\u201351. https:\/\/doi.org\/10.1128\/CMR.00014-09 .","journal-title":"Clin Microbiol Rev"},{"issue":"4","key":"254_CR5","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/nri2939","volume":"11","author":"L Romani","year":"2011","unstructured":"Romani L. Immunity to fungal infections. Nat Rev Immunol. 2011;11(4):275\u201388. https:\/\/doi.org\/10.1038\/nri2939 .","journal-title":"Nat Rev Immunol"},{"key":"254_CR6","doi-asserted-by":"publisher","first-page":"693023","DOI":"10.1155\/2013\/693023","volume":"2013","author":"H Sales-Campos","year":"2013","unstructured":"Sales-Campos H, Tonani L, Cardoso CR, Kress MR. The immune interplay between the host and the pathogen in Aspergillus fumigatus lung infection. Biomed Res Int. 2013;2013:693023. https:\/\/doi.org\/10.1155\/2013\/693023 .","journal-title":"Biomed Res Int"},{"issue":"Suppl 1","key":"254_CR7","doi-asserted-by":"publisher","first-page":"S101","DOI":"10.1080\/13693780500051919","volume":"43","author":"KV Clemons","year":"2005","unstructured":"Clemons KV, Stevens DA. The contribution of animal models of aspergillosis to understanding pathogenesis, therapy and virulence. Med Mycol. 2005;43(Suppl 1):S101\u201310.","journal-title":"Med Mycol"},{"issue":"9","key":"254_CR8","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1086\/522189","volume":"45","author":"L Pagano","year":"2007","unstructured":"Pagano L, Caira M, Nosari A, Van Lint MT, Candoni A, Offidani M, et al. Fungal infections in recipients of hematopoietic stem cell transplants: results of the SEIFEM B-2004 study\u2013Sorveglianza Epidemiologica Infezioni Fungine Nelle Emopatie Maligne. Clin Infect Dis. 2007;45(9):1161\u201370. https:\/\/doi.org\/10.1086\/522189 .","journal-title":"Clin Infect Dis"},{"issue":"5881","key":"254_CR9","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1126\/science.1158441","volume":"320","author":"U Nagalakshmi","year":"2008","unstructured":"Nagalakshmi U, Wang Z, Waern K, Shou C, Raha D, Gerstein M, et al. The transcriptional landscape of the yeast genome defined by RNA sequencing. Science. 2008;320(5881):1344\u20139. https:\/\/doi.org\/10.1126\/science.1158441 .","journal-title":"Science"},{"issue":"5","key":"254_CR10","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/jbiol16","volume":"3","author":"W Zhang","year":"2004","unstructured":"Zhang W, Morris QD, Chang R, Shai O, Bakowski MA, Mitsakakis N, et al. The functional landscape of mouse gene expression. J Biol. 2004;3(5):21. https:\/\/doi.org\/10.1186\/jbiol16 .","journal-title":"J Biol"},{"issue":"1","key":"254_CR11","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1128\/EC.05102-11","volume":"11","author":"JG Gibbons","year":"2012","unstructured":"Gibbons JG, Beauvais A, Beau R, McGary KL, Latge JP, Rokas A. Global transcriptome changes underlying colony growth in the opportunistic human pathogen Aspergillus fumigatus. Eukaryot Cell. 2012;11(1):68\u201378. https:\/\/doi.org\/10.1128\/EC.05102-11 .","journal-title":"Eukaryot Cell"},{"key":"254_CR12","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.1749-6632.2012.06755.x","volume":"1273","author":"A Rokas","year":"2012","unstructured":"Rokas A, Gibbons JG, Zhou X, Beauvais A, Latge JP. The diverse applications of RNA-seq for functional genomic studies in Aspergillus fumigatus. Ann N Y Acad Sci. 2012;1273:25\u201334. https:\/\/doi.org\/10.1111\/j.1749-6632.2012.06755.x .","journal-title":"Ann N Y Acad Sci"},{"issue":"Database issue","key":"254_CR13","doi-asserted-by":"publisher","first-page":"D705","DOI":"10.1093\/nar\/gkt1029","volume":"42","author":"GC Cerqueira","year":"2014","unstructured":"Cerqueira GC, Arnaud MB, Inglis DO, Skrzypek MS, Binkley G, Simison M, et al. The Aspergillus genome database: multispecies curation and incorporation of RNA-Seq data to improve structural gene annotations. Nucleic Acids Res. 2014;42(Database issue):D705\u201310. https:\/\/doi.org\/10.1093\/nar\/gkt1029 .","journal-title":"Nucleic Acids Res"},{"issue":"15","key":"254_CR14","doi-asserted-by":"publisher","first-page":"5075","DOI":"10.1093\/nar\/gkq256","volume":"38","author":"B Wang","year":"2010","unstructured":"Wang B, Guo G, Wang C, Lin Y, Wang X, Zhao M, et al. Survey of the transcriptome of Aspergillus oryzae via massively parallel mRNA sequencing. Nucleic Acids Res. 2010;38(15):5075\u201387. https:\/\/doi.org\/10.1093\/nar\/gkq256 .","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"254_CR15","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/j.1574-6968.2011.02345.x","volume":"322","author":"J Yu","year":"2011","unstructured":"Yu J, Fedorova ND, Montalbano BG, Bhatnagar D, Cleveland TE, Bennett JW, et al. Tight control of mycotoxin biosynthesis gene expression in Aspergillus flavus by temperature as revealed by RNA-Seq. FEMS Microbiol Lett. 2011;322(2):145\u20139. https:\/\/doi.org\/10.1111\/j.1574-6968.2011.02345.x .","journal-title":"FEMS Microbiol Lett"},{"issue":"1","key":"254_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1574-6968.2010.01961.x","volume":"307","author":"T Cairns","year":"2010","unstructured":"Cairns T, Minuzzi F, Bignell E. The host-infecting fungal transcriptome. FEMS Microbiol Lett. 2010;307(1):1\u201311. https:\/\/doi.org\/10.1111\/j.1574-6968.2010.01961.x .","journal-title":"FEMS Microbiol Lett"},{"issue":"5","key":"254_CR17","doi-asserted-by":"publisher","first-page":"e20527","DOI":"10.1371\/journal.pone.0020527","volume":"6","author":"JL Oosthuizen","year":"2011","unstructured":"Oosthuizen JL, Gomez P, Ruan J, Hackett TL, Moore MM, Knight DA, et al. Dual organism transcriptomics of airway epithelial cells interacting with conidia of Aspergillus fumigatus. PLoS ONE. 2011;6(5):e20527. https:\/\/doi.org\/10.1371\/journal.pone.0020527 .","journal-title":"PLoS ONE"},{"issue":"5","key":"254_CR18","doi-asserted-by":"publisher","first-page":"e98279","DOI":"10.1371\/journal.pone.0098279","volume":"9","author":"CO Morton","year":"2014","unstructured":"Morton CO, Fliesser M, Dittrich M, Mueller T, Bauer R, Kneitz S, et al. Gene expression profiles of human dendritic cells interacting with Aspergillus fumigatus in a bilayer model of the alveolar epithelium\/endothelium interface. PLoS ONE. 2014;9(5):e98279. https:\/\/doi.org\/10.1371\/journal.pone.0098279 .","journal-title":"PLoS ONE"},{"issue":"6","key":"254_CR19","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1016\/S0022-5347(17)36396-6","volume":"149","author":"GJ Wise","year":"1993","unstructured":"Wise GJ, Silver DA. Fungal infections of the genitourinary system. J Urol. 1993;149(6):1377\u201388.","journal-title":"J Urol"},{"issue":"12","key":"254_CR20","doi-asserted-by":"publisher","first-page":"4220","DOI":"10.1128\/AAC.01431-07","volume":"52","author":"P Gautam","year":"2008","unstructured":"Gautam P, Shankar J, Madan T, Sirdeshmukh R, Sundaram CS, Gade WN, et al. Proteomic and transcriptomic analysis of Aspergillus fumigatus on exposure to amphotericin B. Antimicrob Agents Chemother. 2008;52(12):4220\u20137. https:\/\/doi.org\/10.1128\/AAC.01431-07 .","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"254_CR21","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1128\/AAC.48.3.1047-1050.2004","volume":"48","author":"KV Clemons","year":"2004","unstructured":"Clemons KV, Stevens DA. Comparative efficacies of four amphotericin B formulations\u2014Fungizone, amphotec (Amphocil), Am Bisome, and Abelcet\u2013against systemic murine aspergillosis. Antimicrob Agents Chemother. 2004;48(3):1047\u201350.","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"254_CR22","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.imlet.2009.12.021","volume":"128","author":"KV Clemons","year":"2010","unstructured":"Clemons KV, Martinez M, Tong AJ, Stevens DA. Resistance of MBL gene-knockout mice to experimental systemic aspergillosis. Immunol Lett. 2010;128(2):105\u20137. https:\/\/doi.org\/10.1016\/j.imlet.2009.12.021 .","journal-title":"Immunol Lett"},{"issue":"8","key":"254_CR23","doi-asserted-by":"publisher","first-page":"818","DOI":"10.3109\/13693786.2012.683539","volume":"50","author":"M Liu","year":"2012","unstructured":"Liu M, Machova E, Nescakova Z, Medovarska I, Clemons KV, Martinez M, et al. Vaccination with mannan protects mice against systemic aspergillosis. Med Mycol. 2012;50(8):818\u201328. https:\/\/doi.org\/10.3109\/13693786.2012.683539 .","journal-title":"Med Mycol"},{"issue":"12","key":"254_CR24","doi-asserted-by":"publisher","first-page":"e28402","DOI":"10.1371\/journal.pone.0028402","volume":"6","author":"J Shankar","year":"2011","unstructured":"Shankar J, Wu TD, Clemons KV, Monteiro JP, Mirels LF, Stevens DA. Influence of 17beta-estradiol on gene expression of Paracoccidioides during mycelia-to-yeast transition. PLoS ONE. 2011;6(12):e28402. https:\/\/doi.org\/10.1371\/journal.pone.0028402 .","journal-title":"PLoS ONE"},{"issue":"3","key":"254_CR25","doi-asserted-by":"publisher","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","volume":"10","author":"B Langmead","year":"2009","unstructured":"Langmead B, Trapnell C, Pop M, Salzberg SL. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol. 2009;10(3):R25. https:\/\/doi.org\/10.1186\/gb-2009-10-3-r25 .","journal-title":"Genome Biol"},{"key":"254_CR26","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1186\/1471-2105-12-323","volume":"12","author":"B Li","year":"2011","unstructured":"Li B, Dewey CN. RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinformatics. 2011;12:323. https:\/\/doi.org\/10.1186\/1471-2105-12-323 .","journal-title":"BMC Bioinformatics"},{"issue":"3","key":"254_CR27","doi-asserted-by":"publisher","first-page":"R25","DOI":"10.1186\/gb-2010-11-3-r25","volume":"11","author":"MD Robinson","year":"2010","unstructured":"Robinson MD, Oshlack A. A scaling normalization method for differential expression analysis of RNA-seq data. Genome Biol. 2010;11(3):R25. https:\/\/doi.org\/10.1186\/gb-2010-11-3-r25 .","journal-title":"Genome Biol"},{"issue":"1","key":"254_CR28","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","volume":"26","author":"MD Robinson","year":"2010","unstructured":"Robinson MD, McCarthy DJ, Smyth GK. edgeR: a bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26(1):139\u201340. https:\/\/doi.org\/10.1093\/bioinformatics\/btp616 .","journal-title":"Bioinformatics"},{"issue":"8","key":"254_CR29","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1038\/nprot.2013.084","volume":"8","author":"BJ Haas","year":"2013","unstructured":"Haas BJ, Papanicolaou A, Yassour M, Grabherr M, Blood PD, Bowden J, et al. De novo transcript sequence reconstruction from RNA-Seq using the Trinity platform for reference generation and analysis. Nat Protoc. 2013;8(8):1494\u2013512. https:\/\/doi.org\/10.1038\/nprot.2013.084 .","journal-title":"Nat Protoc"},{"issue":"7","key":"254_CR30","doi-asserted-by":"publisher","first-page":"e21800","DOI":"10.1371\/journal.pone.0021800","volume":"6","author":"F Supek","year":"2011","unstructured":"Supek F, Bosnjak M, Skunca N, Smuc T. REVIGO summarizes and visualizes long lists of gene ontology terms. PLoS ONE. 2011;6(7):e21800. https:\/\/doi.org\/10.1371\/journal.pone.0021800 .","journal-title":"PLoS ONE"},{"issue":"Suppl 1","key":"254_CR31","doi-asserted-by":"publisher","first-page":"S132","DOI":"10.1080\/13693780802213340","volume":"47","author":"KV Clemons","year":"2009","unstructured":"Clemons KV, Stevens DA. Conventional or molecular measurement of Aspergillus load. Med Mycol. 2009;47(Suppl 1):S132\u20137.","journal-title":"Med Mycol"},{"issue":"4","key":"254_CR32","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1128\/AAC.49.4.1369-1376.2005","volume":"49","author":"G Singh","year":"2005","unstructured":"Singh G, Imai J, Clemons KV, Stevens DA. Efficacy of caspofungin against central nervous system Aspergillus fumigatus infection in mice determined by TaqMan PCR and CFU methods. Antimicrob Agents Chemother. 2005;49(4):1369\u201376. https:\/\/doi.org\/10.1128\/AAC.49.4.1369-1376.2005 .","journal-title":"Antimicrob Agents Chemother"},{"issue":"9","key":"254_CR33","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1007\/s11745-002-0981-4","volume":"37","author":"CJ Furlaneto","year":"2002","unstructured":"Furlaneto CJ, Ribeiro FP, Hatanaka E, Souza GM, Cassatella MA, Campa A. Apolipoproteins A-I and A-II downregulate neutrophil functions. Lipids. 2002;37(9):925\u20138.","journal-title":"Lipids"},{"issue":"4","key":"254_CR34","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1128\/IAI.72.4.2338-2349.2004","volume":"72","author":"CML Maffei","year":"2004","unstructured":"Maffei CML, Mirels LF, Sobel RA, Clemons KV, Stevens DA. Cytokine and inducible nitric oxide synthase mRNA expression during experimental murine cryptococcal meningoencephalitis. Infect Immun. 2004;72(4):2338\u201349. https:\/\/doi.org\/10.1128\/IAI.72.4.2338-2349.2004 .","journal-title":"Infect Immun"},{"issue":"1","key":"254_CR35","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.cyto.2012.08.024","volume":"61","author":"R Anand","year":"2013","unstructured":"Anand R, Shankar J, Singh AP, Tiwary BN. Cytokine milieu in renal cavities of immunocompetent mice in response to intravenous challenge of Aspergillus flavus leading to aspergillosis. Cytokine. 2013;61(1):63\u201370. https:\/\/doi.org\/10.1016\/j.cyto.2012.08.024 .","journal-title":"Cytokine"},{"issue":"7\u20138","key":"254_CR36","doi-asserted-by":"publisher","first-page":"751","DOI":"10.3109\/08820139.2011.614307","volume":"40","author":"DA Stevens","year":"2011","unstructured":"Stevens DA, Melikian GL. Aspergillosis in the \u2018nonimmunocompromised\u2019 host. Immunol Invest. 2011;40(7\u20138):751\u201366. https:\/\/doi.org\/10.3109\/08820139.2011.614307 .","journal-title":"Immunol Invest"},{"issue":"Supplement 1","key":"254_CR37","doi-asserted-by":"publisher","first-page":"S119","DOI":"10.1080\/13693780600871174","volume":"44","author":"KV Clemons","year":"2006","unstructured":"Clemons KV, Stevens DA. Animal models of Aspergillus infection in preclinical trials, diagnostics and pharmacodynamics: what can we learn from them? Med Mycol. 2006;44(Supplement 1):S119\u201326. https:\/\/doi.org\/10.1080\/13693780600871174 .","journal-title":"Med Mycol"},{"issue":"1\u20132","key":"254_CR38","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1007\/s12026-012-8274-x","volume":"52","author":"I Mirkov","year":"2012","unstructured":"Mirkov I, Stosic-Grujicic S, Kataranovski M. Host immune defense against Aspergillus fumigatus: insight from experimental systemic (disseminated) infection. Immunol Res. 2012;52(1\u20132):120\u20136. https:\/\/doi.org\/10.1007\/s12026-012-8274-x .","journal-title":"Immunol Res"},{"issue":"8","key":"254_CR39","doi-asserted-by":"publisher","first-page":"R73","DOI":"10.1186\/gb-2011-12-8-r73","volume":"12","author":"A Melnikov","year":"2011","unstructured":"Melnikov A, Galinsky K, Rogov P, Fennell T, Van Tyne D, Russ C, et al. Hybrid selection for sequencing pathogen genomes from clinical samples. Genome Biol. 2011;12(8):R73. https:\/\/doi.org\/10.1186\/gb-2011-12-8-r73 .","journal-title":"Genome Biol"},{"key":"254_CR40","doi-asserted-by":"publisher","first-page":"192","DOI":"10.3389\/fmicb.2016.00192","volume":"7","author":"R Thakur","year":"2016","unstructured":"Thakur R, Shankar J. In silico analysis revealed high-risk single nucleotide polymorphisms in human pentraxin-3 gene and their impact on innate immune response against microbial pathogens. Front Microbiol. 2016;7:192. https:\/\/doi.org\/10.3389\/fmicb.2016.00192 .","journal-title":"Front Microbiol"},{"issue":"1","key":"254_CR41","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nri1745","volume":"6","author":"GD Brown","year":"2006","unstructured":"Brown GD. Dectin-1: a signalling non-TLR pattern-recognition receptor. Nat Rev Immunol. 2006;6(1):33\u201343. https:\/\/doi.org\/10.1038\/nri1745 .","journal-title":"Nat Rev Immunol"},{"key":"254_CR42","doi-asserted-by":"publisher","first-page":"429","DOI":"10.3389\/fmicb.2015.00429","volume":"6","author":"R Thakur","year":"2015","unstructured":"Thakur R, Anand R, Tiwari S, Singh AP, Tiwary BN, Shankar J. Cytokines induce effector T-helper cells during invasive aspergillosis; what we have learned about T-helper cells? Front Microbiol. 2015;6:429. https:\/\/doi.org\/10.3389\/fmicb.2015.00429 .","journal-title":"Front Microbiol."},{"issue":"s1","key":"254_CR43","doi-asserted-by":"publisher","first-page":"S229","DOI":"10.1080\/13693780600760773","volume":"44","author":"DA Stevens","year":"2006","unstructured":"Stevens DA. Th1\/Th2 in aspergillosis. Med Mycol. 2006;44(s1):S229\u201335. https:\/\/doi.org\/10.1080\/13693780600760773 .","journal-title":"Med Mycol"},{"issue":"8","key":"254_CR44","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1086\/605931","volume":"200","author":"DP Armstrong-James","year":"2009","unstructured":"Armstrong-James DP, Turnbull SA, Teo I, Stark J, Rogers NJ, Rogers TR, et al. Impaired interferon-gamma responses, increased interleukin-17 expression, and a tumor necrosis factor-alpha transcriptional program in invasive aspergillosis. J Infect Dis. 2009;200(8):1341\u201351. https:\/\/doi.org\/10.1086\/605931 .","journal-title":"J Infect Dis"},{"issue":"2","key":"254_CR45","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.cyto.2015.01.006","volume":"72","author":"R Anand","year":"2015","unstructured":"Anand R, Shankar J, Tiwary BN, Singh AP. Aspergillus flavus induces granulomatous cerebral aspergillosis in mice with display of distinct cytokine profile. Cytokine. 2015;72(2):166\u201372. https:\/\/doi.org\/10.1016\/j.cyto.2015.01.006 .","journal-title":"Cytokine"},{"issue":"5","key":"254_CR46","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.4049\/jimmunol.1300426","volume":"191","author":"A Flaczyk","year":"2013","unstructured":"Flaczyk A, Duerr CU, Shourian M, Lafferty EI, Fritz JH, Qureshi ST. IL-33 signaling regulates innate and adaptive immunity to Cryptococcus neoformans. J Immunol. 2013;191(5):2503\u201313. https:\/\/doi.org\/10.4049\/jimmunol.1300426 .","journal-title":"J Immunol"},{"issue":"8","key":"254_CR47","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.1128\/IAI.01990-14","volume":"82","author":"EM O\u2019Dea","year":"2014","unstructured":"O\u2019Dea EM, Amarsaikhan N, Li H, Downey J, Steele E, Van Dyken SJ, et al. Eosinophils are recruited in response to chitin exposure and enhance Th2-mediated immune pathology in Aspergillus fumigatus infection. Infect Immun. 2014;82(8):3199\u2013205. https:\/\/doi.org\/10.1128\/IAI.01990-14 .","journal-title":"Infect Immun"},{"issue":"1","key":"254_CR48","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1476-9255-8-22","volume":"8","author":"AM Miller","year":"2011","unstructured":"Miller AM. Role of IL-33 in inflammation and disease. J Inflamm (Lond). 2011;8(1):22. https:\/\/doi.org\/10.1186\/1476-9255-8-22 .","journal-title":"J Inflamm (Lond)"},{"issue":"8","key":"254_CR49","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1093\/intimm\/dxn060","volume":"20","author":"MD Smithgall","year":"2008","unstructured":"Smithgall MD, Comeau MR, Yoon BR, Kaufman D, Armitage R, Smith DE. IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells. Int Immunol. 2008;20(8):1019\u201330. https:\/\/doi.org\/10.1093\/intimm\/dxn060 .","journal-title":"Int Immunol"},{"issue":"1","key":"254_CR50","doi-asserted-by":"publisher","first-page":"e1004625","DOI":"10.1371\/journal.ppat.1004625","volume":"11","author":"AK Caffrey","year":"2015","unstructured":"Caffrey AK, Lehmann MM, Zickovich JM, Espinosa V, Shepardson KM, Watschke CP, et al. IL-1alpha signaling is critical for leukocyte recruitment after pulmonary Aspergillus fumigatus challenge. PLoS Pathog. 2015;11(1):e1004625. https:\/\/doi.org\/10.1371\/journal.ppat.1004625PPATHOGENS-D-14-01338 .","journal-title":"PLoS Pathog"},{"issue":"4","key":"254_CR51","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.1128\/IAI.74.4.2353-2365.2006","volume":"74","author":"KJ Cortez","year":"2006","unstructured":"Cortez KJ, Lyman CA, Kottilil S, Kim HS, Roilides E, Yang J, et al. Functional genomics of innate host defense molecules in normal human monocytes in response to Aspergillus fumigatus. Infect Immun. 2006;74(4):2353\u201365. https:\/\/doi.org\/10.1128\/IAI.74.4.2353-2365.2006 .","journal-title":"Infect Immun"},{"issue":"4","key":"254_CR52","doi-asserted-by":"publisher","first-page":"e0153829","DOI":"10.1371\/journal.pone.0153829","volume":"11","author":"A Savers","year":"2016","unstructured":"Savers A, Rasid OP, Brock M, Jouvion G, Ryffel B, Cavaillon J-M, et al. Infection-mediated priming of phagocytes protects against lethal secondary Aspergillus fumigatus challenge. PLoS ONE. 2016;11(4):e0153829. https:\/\/doi.org\/10.1371\/journal.pone.0153829 .","journal-title":"PLoS ONE"},{"issue":"2","key":"254_CR53","doi-asserted-by":"publisher","first-page":"e56045","DOI":"10.1371\/journal.pone.0056045","volume":"8","author":"ED Foucher","year":"2013","unstructured":"Foucher ED, Blanchard S, Preisser L, Garo E, Ifrah N, Guardiola P, et al. IL-34 induces the differentiation of human monocytes into immunosuppressive macrophages. Antagonistic effects of GM-CSF and IFNgamma. PLoS ONE. 2013;8(2):e56045. https:\/\/doi.org\/10.1371\/journal.pone.0056045 .","journal-title":"PLoS ONE"},{"issue":"3","key":"254_CR54","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.cytogfr.2011.06.001","volume":"22","author":"M Liu","year":"2011","unstructured":"Liu M, Guo S, Hibbert JM, Jain V, Singh N, Wilson NO, et al. CXCL10\/IP-10 in infectious diseases pathogenesis and potential therapeutic implications. Cytokine Growth Factor Rev. 2011;22(3):121\u201330. https:\/\/doi.org\/10.1016\/j.cytogfr.2011.06.001 .","journal-title":"Cytokine Growth Factor Rev"},{"issue":"9","key":"254_CR55","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1086\/656527","volume":"202","author":"L Chai","year":"2010","unstructured":"Chai L, Netea MG, Teerenstra S, Earnest A, Vonk AG, Schlamm HT, et al. Early proinflammatory cytokines and C-reactive protein trends as predictors of outcome in invasive Aspergillosis. J Infect Dis. 2010;202(9):1454\u201362. https:\/\/doi.org\/10.1086\/656527 .","journal-title":"J Infect Dis"},{"key":"254_CR56","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/1471-2334-12-144","volume":"12","author":"EK Rodland","year":"2012","unstructured":"Rodland EK, Ueland T, Bjornsen S, Sagen EL, Dahl CP, Naalsund A, et al. Systemic biomarkers of inflammation and haemostasis in patients with chronic necrotizing pulmonary aspergillosis. BMC Infect Dis. 2012;12:144. https:\/\/doi.org\/10.1186\/1471-2334-12-144 .","journal-title":"BMC Infect Dis"},{"issue":"3","key":"254_CR57","first-page":"907","volume":"20","author":"L Bendall","year":"2005","unstructured":"Bendall L. Chemokines and their receptors in disease. Histol Histopathol. 2005;20(3):907\u201326.","journal-title":"Histol Histopathol"},{"issue":"1","key":"254_CR58","doi-asserted-by":"publisher","first-page":"122","DOI":"10.4049\/jimmunol.180.1.122","volume":"180","author":"HW Lim","year":"2008","unstructured":"Lim HW, Lee J, Hillsamer P, Kim CH. Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3\u00a0+\u00a0regulatory T cells. J Immunol. 2008;180(1):122\u20139.","journal-title":"J Immunol"},{"issue":"1","key":"254_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pharmthera.2010.04.006","volume":"127","author":"EM Borroni","year":"2010","unstructured":"Borroni EM, Mantovani A, Locati M, Bonecchi R. Chemokine receptors intracellular trafficking. Pharmacol Ther. 2010;127(1):1\u20138. https:\/\/doi.org\/10.1016\/j.pharmthera.2010.04.006 .","journal-title":"Pharmacol Ther"},{"issue":"3","key":"254_CR60","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1124\/dmd.105.007393","volume":"34","author":"TA Richardson","year":"2006","unstructured":"Richardson TA, Sherman M, Antonovic L, Kardar SS, Strobel HW, Kalman D, et al. Hepatic and renal cytochrome p450 gene regulation during citrobacter rodentium infection in wild-type and toll-like receptor 4 mutant mice. Drug Metab Dispos. 2006;34(3):354\u201360. https:\/\/doi.org\/10.1124\/dmd.105.007393 .","journal-title":"Drug Metab Dispos"},{"issue":"4","key":"254_CR61","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/clpt.2008.302","volume":"85","author":"ET Morgan","year":"2009","unstructured":"Morgan ET. Impact of infectious and inflammatory disease on cytochrome P450-mediated drug metabolism and pharmacokinetics. Clin Pharmacol Ther. 2009;85(4):434\u20138. https:\/\/doi.org\/10.1038\/clpt.2008.302 .","journal-title":"Clin Pharmacol Ther"},{"issue":"4","key":"254_CR62","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.3109\/03602539709002246","volume":"29","author":"ET Morgan","year":"1997","unstructured":"Morgan ET. Regulation of cytochromes P450 during inflammation and infection. Drug Metab Rev. 1997;29(4):1129\u201388. https:\/\/doi.org\/10.3109\/03602539709002246 .","journal-title":"Drug Metab Rev"},{"issue":"1","key":"254_CR63","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1124\/dmd.110.035287","volume":"39","author":"KN Theken","year":"2011","unstructured":"Theken KN, Deng Y, Kannon MA, Miller TM, Poloyac SM, Lee CR. Activation of the acute inflammatory response alters cytochrome P450 expression and eicosanoid metabolism. Drug metabolism and disposition: the biological fate of chemicals. 2011;39(1):22\u20139. https:\/\/doi.org\/10.1124\/dmd.110.035287 .","journal-title":"Drug metabolism and disposition: the biological fate of chemicals."},{"issue":"11","key":"254_CR64","first-page":"1366","volume":"29","author":"ET Morgan","year":"2001","unstructured":"Morgan ET, Ullrich V, Daiber A, Schmidt P, Takaya N, Shoun H, et al. Cytochromes P450 and flavin monooxygenases\u2013targets and sources of nitric oxide. Drug Metab Dispos. 2001;29(11):1366\u201376.","journal-title":"Drug Metab Dispos"},{"issue":"4","key":"254_CR65","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1517\/17425255.3.4.583","volume":"3","author":"A Walubo","year":"2007","unstructured":"Walubo A. The role of cytochrome P450 in antiretroviral drug interactions. Expert Opin Drug Metab Toxicol. 2007;3(4):583\u201398. https:\/\/doi.org\/10.1517\/17425225.3.4.583 .","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"10","key":"254_CR66","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1056\/NEJM199103073241003","volume":"324","author":"DW Denning","year":"1991","unstructured":"Denning DW, Follansbee SE, Scolaro M, Norris S, Edelstein H, Stevens DA. Pulmonary aspergillosis in the acquired immunodeficiency syndrome. N Engl J Med. 1991;324(10):654\u201362. https:\/\/doi.org\/10.1056\/NEJM199103073241003 .","journal-title":"N Engl J Med"},{"issue":"7","key":"254_CR67","doi-asserted-by":"publisher","first-page":"e1003436","DOI":"10.1371\/journal.ppat.1003436","volume":"9","author":"SM Leal Jr","year":"2013","unstructured":"Leal SM Jr, Roy S, Vareechon C, Carrion S, Clark H, Lopez-Berges MS, et al. Targeting iron acquisition blocks infection with the fungal pathogens Aspergillus fumigatus and Fusarium oxysporum. PLoS Pathog. 2013;9(7):e1003436. https:\/\/doi.org\/10.1371\/journal.ppat.1003436 .","journal-title":"PLoS Pathog"},{"issue":"7019","key":"254_CR68","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nature03104","volume":"432","author":"TH Flo","year":"2004","unstructured":"Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature. 2004;432(7019):917\u201321. https:\/\/doi.org\/10.1038\/nature03104 .","journal-title":"Nature"},{"issue":"9","key":"254_CR69","doi-asserted-by":"publisher","first-page":"457","DOI":"10.17221\/1978-VETMED","volume":"53","author":"L Adlerova","year":"2008","unstructured":"Adlerova L, Bartoskova A, Faldyna M. Lactoferrin: a review. Vet Med. 2008;53(9):457\u201368.","journal-title":"Vet Med"},{"issue":"2","key":"254_CR70","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/0005-2795(72)90283-8","volume":"257","author":"P Aisen","year":"1972","unstructured":"Aisen P, Leibman A. Lactoferrin and transferrin: a comparative study. Biochim Biophys Acta. 1972;257(2):314\u201323.","journal-title":"Biochim Biophys Acta"},{"issue":"22","key":"254_CR71","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1007\/s00018-005-5370-2","volume":"62","author":"D Legrand","year":"2005","unstructured":"Legrand D, Elass E, Carpentier M, Mazurier J. Lactoferrin: a modulator of immune and inflammatory responses. Cell Mol Life Sci. 2005;62(22):2549\u201359. https:\/\/doi.org\/10.1007\/s00018-005-5370-2 .","journal-title":"Cell Mol Life Sci"},{"issue":"31","key":"254_CR72","doi-asserted-by":"crossref","first-page":"16358","DOI":"10.1016\/S0021-9258(18)37601-4","volume":"263","author":"MJ McPhaul","year":"1988","unstructured":"McPhaul MJ, Noble JF, Simpson ER, Mendelson CR, Wilson JD. The expression of a functional cDNA encoding the chicken cytochrome P-450arom (aromatase) that catalyzes the formation of estrogen from androgen. J Biol Chem. 1988;263(31):16358\u201363.","journal-title":"J Biol Chem"},{"issue":"3","key":"254_CR73","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1385\/IR:34:3:177","volume":"34","author":"I Marriott","year":"2006","unstructured":"Marriott I, Huet-Hudson YM. Sexual dimorphism in innate immune responses to infectious organisms. Immunol Res. 2006;34(3):177\u201392. https:\/\/doi.org\/10.1385\/ir:34:3:177 .","journal-title":"Immunol Res"},{"issue":"6","key":"254_CR74","first-page":"934","volume":"30","author":"B Villaggio","year":"2012","unstructured":"Villaggio B, Soldano S, Cutolo M. 1,25-Dihydroxyvitamin D3 downregulates aromatase expression and inflammatory cytokines in human macrophages. Clin Exp Rheumatol. 2012;30(6):934\u20138.","journal-title":"Clin Exp Rheumatol"},{"issue":"5","key":"254_CR75","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/S1043-2760(00)00254-X","volume":"11","author":"E Simpson","year":"2000","unstructured":"Simpson E, Rubin G, Clyne C, Robertson K, O\u2019Donnell L, Jones M, et al. The role of local estrogen biosynthesis in males and females. Trends Endocrinol Metab. 2000;11(5):184\u20138.","journal-title":"Trends Endocrinol Metab"},{"key":"254_CR76","first-page":"185","volume":"52","author":"ER Simpson","year":"1997","unstructured":"Simpson ER, Zhao Y, Agarwal VR, Michael MD, Bulun SE, Hinshelwood MM, et al. Aromatase expression in health and disease. Recent Prog Horm Res. 1997;52:185\u2013213 Discussion-4.","journal-title":"Recent Prog Horm Res"},{"issue":"4","key":"254_CR77","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1210\/endo.141.4.7404","volume":"141","author":"S Cuzzocrea","year":"2000","unstructured":"Cuzzocrea S, Santagati S, Sautebin L, Mazzon E, Calabro G, Serraino I, et al. 17Beta-estradiol antiinflammatory activity in carrageenan-induced pleurisy. Endocrinology. 2000;141(4):1455\u201363.","journal-title":"Endocrinology"},{"issue":"26","key":"254_CR78","doi-asserted-by":"publisher","first-page":"5393","DOI":"10.1182\/blood-2009-07-231209","volume":"114","author":"R Ben-Ami","year":"2009","unstructured":"Ben-Ami R, Lewis RE, Leventakos K, Kontoyiannis DP. Aspergillus fumigatus inhibits angiogenesis through the production of gliotoxin and other secondary metabolites. Blood. 2009;114(26):5393\u20139. https:\/\/doi.org\/10.1182\/blood-2009-07-231209 .","journal-title":"Blood"},{"issue":"10","key":"254_CR79","doi-asserted-by":"publisher","first-page":"e77136","DOI":"10.1371\/journal.pone.0077136","volume":"8","author":"JL Hsu","year":"2013","unstructured":"Hsu JL, Khan MA, Sobel RA, Jiang X, Clemons KV, Nguyen TT, et al. Aspergillus fumigatus invasion increases with progressive airway ischemia. PLoS ONE. 2013;8(10):e77136. https:\/\/doi.org\/10.1371\/journal.pone.0077136PONE-D-13-14976 .","journal-title":"PLoS ONE"},{"issue":"1","key":"254_CR80","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1161\/01.RES.0000153188.68898.ac","volume":"96","author":"S Frantz","year":"2005","unstructured":"Frantz S, Vincent KA, Feron O, Kelly RA. Innate immunity and angiogenesis. Circ Res. 2005;96(1):15\u201326. https:\/\/doi.org\/10.1161\/01.RES.0000153188.68898.ac .","journal-title":"Circ Res"},{"issue":"1","key":"254_CR81","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1172\/JCI9775","volume":"107","author":"P Romagnani","year":"2001","unstructured":"Romagnani P, Annunziato F, Lasagni L, Lazzeri E, Beltrame C, Francalanci M, et al. Cell cycle-dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activity. J Clin Investig. 2001;107(1):53\u201363. https:\/\/doi.org\/10.1172\/JCI9775 .","journal-title":"J Clin Investig"},{"issue":"7","key":"254_CR82","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/labinvest.2013.71","volume":"93","author":"M Miyake","year":"2013","unstructured":"Miyake M, Goodison S, Urquidi V, Gomes Giacoia E, Rosser CJ. Expression of CXCL1 in human endothelial cells induces angiogenesis through the CXCR2 receptor and the ERK1\/2 and EGF pathways. Lab Invest. 2013;93(7):768\u201378. https:\/\/doi.org\/10.1038\/labinvest.2013.71 .","journal-title":"Lab Invest"}],"container-title":["Mycopathologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11046-018-0254-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-018-0254-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-018-0254-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T04:30:21Z","timestamp":1660537821000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11046-018-0254-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,2]]},"references-count":82,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["254"],"URL":"https:\/\/doi.org\/10.1007\/s11046-018-0254-9","relation":{},"ISSN":["0301-486X","1573-0832"],"issn-type":[{"value":"0301-486X","type":"print"},{"value":"1573-0832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,2]]},"assertion":[{"value":"17 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Sequencing runs were deposited at Short Read Archive (SRA-NCBI) under the following accession identifiers: SRX1201397, SRX1201396, SRX1201395, SRX1201394, SRX1201392.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of Data and Material"}},{"value":"All animal studies were using a protocol approved by the Institutional Animal Care and Use Committee of the California Institute for Medical Research (CIMR) under protocol numbers 09-01:3 and 12-01:1.\u00a0Animal Care and Use protocols followed the Animal Welfare Act (7 U.S.C. 2131et\u00a0seq.) and the Office of Laboratory Animal Welfare\u2014Public Health Service Policy on Humane Care and Use of Laboratory Animals. CIMR protocols were approved and performed under OLAW assurance number, A3652-01. The NRC Guidelines for the Care and Use of Laboratory Animals, 8th edition, were followed for all care and use of mice. Mice were euthanized using CO2narcosis per the 2007 version of the American Veterinary Medical Association (AVMA) guidelines, which was the time the animal studies were performed.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}}]}}