{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:04:29Z","timestamp":1790431469221,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T00:00:00Z","timestamp":1568851200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"The Scientific and Technological Innovation Projects of Medicine and Health of Chinese Academy of Medical Sciences","award":["2016-I2M-3-021"],"award-info":[{"award-number":["2016-I2M-3-021"]}]},{"name":"The Basical Scientific Research Fund Projects of Chinese Academy of Medical Sciences","award":["2018PT31013"],"award-info":[{"award-number":["2018PT31013"]}]},{"name":"The Basic Scientific Research Fund Projects of Chinese Academy of Medical Sciences","award":["3332018121"],"award-info":[{"award-number":["3332018121"]}]},{"name":"The subitem of the Important and Special Project of the Science and Technology Ministry of China","award":["2018ZX10734404"],"award-info":[{"award-number":["2018ZX10734404"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mycopathologia"],"DOI":"10.1007\/s11046-019-00384-1","type":"journal-article","created":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T19:02:26Z","timestamp":1568919746000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Whole-genome resequencing of Trichophyton rubrum provides insights into population differentiation and drug resistance"],"prefix":"10.1007","author":[{"given":"Hailin","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Blechert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyu","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. S.","family":"de Hoog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weida","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,19]]},"reference":[{"issue":"4","key":"384_CR1","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1097\/00008480-200108000-00008","volume":"13","author":"BK Chen","year":"2001","unstructured":"Chen BK, Friedlander SF. Tinea capitis update: a continuing conflict with an old adversary. Curr Opin Pediatr. 2001;13(4):331\u20135.","journal-title":"Curr Opin Pediatr"},{"issue":"2","key":"384_CR2","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1128\/CMR.8.2.240","volume":"8","author":"I Weitzman","year":"1995","unstructured":"Weitzman I, Summerbell RC. The dermatophytes. Clin Microbiol Rev. 1995;8(2):240\u201359.","journal-title":"Clin Microbiol Rev"},{"issue":"1","key":"384_CR3","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1128\/AAC.47.1.82-86.2003","volume":"47","author":"PK Mukherjee","year":"2003","unstructured":"Mukherjee PK, et al. Clinical Trichophyton rubrum strain exhibiting primary resistance to terbinafine. Antimicrob Agents Chemother. 2003;47(1):82\u20136.","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"384_CR4","doi-asserted-by":"publisher","first-page":"281","DOI":"10.4103\/ijdvl.IJDVL_224_17","volume":"83","author":"S Panda","year":"2017","unstructured":"Panda S, Verma S. The menace of dermatophytosis in India: the evidence that we need. Indian J Dermatol Venereol Leprol. 2017;83(3):281\u20134.","journal-title":"Indian J Dermatol Venereol Leprol"},{"issue":"7","key":"384_CR5","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1111\/myc.12772","volume":"61","author":"A Singh","year":"2018","unstructured":"Singh A, et al. High terbinafine resistance in Trichophyton interdigitale isolates in Delhi, India harbouring mutations in the squalene epoxidase gene. Mycoses. 2018;61(7):477\u201384.","journal-title":"Mycoses"},{"issue":"7","key":"384_CR6","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1111\/myc.12492","volume":"59","author":"M Didehdar","year":"2016","unstructured":"Didehdar M, et al. Development of a high-resolution melting analysis assay for rapid and high-throughput identification of clinically important dermatophyte species. Mycoses. 2016;59(7):442\u20139.","journal-title":"Mycoses"},{"issue":"4","key":"384_CR7","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1534\/genetics.117.300573","volume":"208","author":"GF Persinoti","year":"2018","unstructured":"Persinoti GF, et al. Whole-genome analysis illustrates global clonal population structure of the ubiquitous dermatophyte pathogen Trichophyton rubrum. Genetics. 2018;208(4):1657\u201369.","journal-title":"Genetics"},{"issue":"1","key":"384_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/gb-2011-12-1-r7","volume":"12","author":"A Burmester","year":"2011","unstructured":"Burmester A, et al. Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. Genome Biol. 2011;12(1):1\u201316.","journal-title":"Genome Biol"},{"issue":"13","key":"384_CR9","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1016\/j.cub.2005.05.045","volume":"15","author":"M Paoletti","year":"2005","unstructured":"Paoletti M, et al. Evidence for sexuality in the opportunistic fungal pathogen Aspergillus fumigatus. Curr Biol. 2005;15(13):1242\u20138.","journal-title":"Curr Biol"},{"issue":"6","key":"384_CR10","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.mib.2008.09.014","volume":"11","author":"YP Hsueh","year":"2008","unstructured":"Hsueh YP, Heitman J. Orchestration of sexual reproduction and virulence by the fungal mating-type locus. Curr Opin Microbiol. 2008;11(6):517\u201324.","journal-title":"Curr Opin Microbiol"},{"issue":"1","key":"384_CR11","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1128\/EC.00259-09","volume":"9","author":"W Li","year":"2010","unstructured":"Li W, et al. Organization and evolutionary trajectory of the mating type (MAT) locus in dermatophyte and dimorphic fungal pathogens. Eukaryot Cell. 2010;9(1):46\u201358.","journal-title":"Eukaryot Cell"},{"issue":"1\u20132","key":"384_CR12","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s11046-016-0072-x","volume":"182","author":"B Metin","year":"2017","unstructured":"Metin B, Heitman J. Sexual reproduction in dermatophytes. Mycopathologia. 2017;182(1\u20132):45\u201355.","journal-title":"Mycopathologia"},{"issue":"1","key":"384_CR13","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.fgb.2018.07.003","volume":"118","author":"S Kosanke","year":"2018","unstructured":"Kosanke S, et al. Unequal distribution of the mating type (MAT) locus idiomorphs in dermatophyte species. Fungal Genet Biol. 2018;118(1):45\u201353.","journal-title":"Fungal Genet Biol"},{"issue":"5","key":"384_CR14","doi-asserted-by":"publisher","first-page":"e00259","DOI":"10.1128\/mBio.00259-12","volume":"3","author":"DA Martinez","year":"2012","unstructured":"Martinez DA, et al. Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection. MBio. 2012;3(5):e00259\u2013e312. https:\/\/doi.org\/10.1128\/mBio.00259-12 .","journal-title":"MBio"},{"issue":"1\u20132","key":"384_CR15","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s11046-012-9603-2","volume":"175","author":"R Kano","year":"2013","unstructured":"Kano R, et al. Mating type gene (MAT1-1) in Japanese isolates of Trichophyton rubrum. Mycopathologia. 2013;175(1\u20132):171\u20133.","journal-title":"Mycopathologia"},{"issue":"2","key":"384_CR16","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1080\/00362176885190281","volume":"6","author":"CN Young","year":"1968","unstructured":"Young CN. Pseudo-cleistothecia in Trichophyton rubrum. Sabouraudia. 1968;6(2):160\u20132.","journal-title":"Sabouraudia"},{"issue":"4","key":"384_CR17","doi-asserted-by":"publisher","first-page":"629","DOI":"10.3109\/13693780903437884","volume":"48","author":"K Anzawa","year":"2010","unstructured":"Anzawa K, et al. Successful mating of Trichophyton rubrum with Arthroderma simii. Med Mycol. 2010;48(4):629\u201334.","journal-title":"Med Mycol"},{"issue":"6","key":"384_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/mBio.00381-12","volume":"3","author":"ZS Rivera","year":"2012","unstructured":"Rivera ZS, Losada L, Nierman WC. Back to the future for dermatophyte genomics. MBio. 2012;3(6):1\u20133. https:\/\/doi.org\/10.1128\/mBio.00381-12 .","journal-title":"MBio"},{"key":"384_CR19","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.simyco.2018.02.004","volume":"89","author":"P Zhan","year":"2018","unstructured":"Zhan P, et al. Phylogeny of dermatophytes with genomic character evaluation of clinically distinct Trichophyton rubrum and T. violaceum. Stud Mycol. 2018;89:153\u201375.","journal-title":"Stud Mycol."},{"issue":"7","key":"384_CR20","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1093\/molbev\/msw054","volume":"33","author":"S Kumar","year":"2016","unstructured":"Kumar S, Stecher G, Tamura K. MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets. Mol Biol Evolut. 2016;33(7):1870\u20134.","journal-title":"Mol Biol Evolut."},{"issue":"1","key":"384_CR21","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1111\/1755-0998.12719","volume":"18","author":"YL Li","year":"2018","unstructured":"Li YL, Liu JX. StructureSelector: a web-based software to select and visualize the optimal number of clusters using multiple methods. Mol Ecol Resour. 2018;18(1):176\u20137.","journal-title":"Mol Ecol Resour."},{"issue":"8","key":"384_CR22","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1111\/j.1365-294X.2005.02553.x","volume":"14","author":"G Evanno","year":"2005","unstructured":"Evanno G, Regnaut S, Goudet J. Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. Mol Ecol. 2005;14(8):2611\u201320.","journal-title":"Mol Ecol."},{"issue":"19","key":"384_CR23","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1093\/bioinformatics\/btm308","volume":"23","author":"PJ Bradbury","year":"2007","unstructured":"Bradbury PJ, et al. TASSEL: software for association mapping of complex traits in diverse samples. Bioinformatics. 2007;23(19):2633\u20135.","journal-title":"Bioinformatics"},{"issue":"4","key":"384_CR24","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1214\/aos\/1013699998","volume":"29","author":"Y Benjamini","year":"2001","unstructured":"Benjamini Y, Yekutieli D. The control of the false discovery rate in multiple testing under dependency. Ann Stat. 2001;29(4):1165\u201388.","journal-title":"Ann Stat."},{"issue":"1","key":"384_CR25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.7547\/14-109","volume":"106","author":"M Ghannoum","year":"2016","unstructured":"Ghannoum M. Azole resistance in dermatophytes. JAPMA. 2016;106(1):79\u201386.","journal-title":"JAPMA"},{"issue":"5","key":"384_CR26","doi-asserted-by":"publisher","first-page":"2825","DOI":"10.1128\/AAC.02382-13","volume":"58","author":"E Ghelardi","year":"2014","unstructured":"Ghelardi E, et al. Potential of ergosterol synthesis inhibitors to cause resistance or cross-resistance in Trichophyton rubrum. Antimicrob Agents Chemother. 2014;58(5):2825\u20139.","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"384_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/AAC.02522-17","volume":"62","author":"SM Rudramurthy","year":"2018","unstructured":"Rudramurthy SM, et al. Mutation in the squalene epoxidase gene of Trichophyton interdigitale and Trichophyton rubrum associated with allylamine resistance. Antimicrob Agents Chemother. 2018;62(5):1\u201327.","journal-title":"Antimicrob Agents Chemother"},{"issue":"11","key":"384_CR28","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1128\/JCM.37.11.3713-3717.1999","volume":"37","author":"Y Graser","year":"1999","unstructured":"Graser Y, Kuhnisch J, Presber W. Molecular markers reveal exclusively clonal reproduction in Trichophyton rubrum. J Clin Microbiol. 1999;37(11):3713\u20137.","journal-title":"J Clin Microbiol."},{"issue":"1","key":"384_CR29","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.fgb.2016.08.002","volume":"95","author":"J Gong","year":"2016","unstructured":"Gong J, et al. Population differentiation and genetic diversity of Trichophyton rubrum as revealed by highly discriminatory microsatellites. Fungal Genet Biol. 2016;95(1):24\u20139.","journal-title":"Fungal Genet Biol"},{"issue":"2","key":"384_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pgen.1002528","volume":"8","author":"K Findley","year":"2012","unstructured":"Findley K, et al. Discovery of a modified tetrapolar sexual cycle in Cryptococcus amylolentus and the evolution of MAT in the Cryptococcus species complex. PLoS Genet. 2012;8(2):1\u201319.","journal-title":"PLoS Genet."},{"issue":"6","key":"384_CR31","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1101\/gr.217356.116","volume":"27","author":"HJ Painter","year":"2017","unstructured":"Painter HJ, Carrasquilla M, Llinas M. Capturing in vivo RNA transcriptional dynamics from the malaria parasite Plasmodium falciparum. Genome Res. 2017;27(6):1074\u201386.","journal-title":"Genome Res"},{"issue":"249","key":"384_CR32","first-page":"1","volume":"17","author":"TA Bitencourt","year":"2016","unstructured":"Bitencourt TA, et al. Transcription profile of Trichophyton rubrum conidia grown on keratin reveals the induction of an adhesin-like protein gene with a tandem repeat pattern. BMC Genomics. 2016;17(249):1\u201314.","journal-title":"BMC Genomics"},{"issue":"3","key":"384_CR33","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1128\/JVI.67.3.1441-1452.1993","volume":"67","author":"JD Baines","year":"1993","unstructured":"Baines JD, Roizman B. The UL10 gene of herpes simplex virus 1 encodes a novel viral glycoprotein, gM, which is present in the virion and in the plasma membrane of infected cells. J Virol. 1993;67(3):1441\u2013522.","journal-title":"J Virol"},{"issue":"24","key":"384_CR34","doi-asserted-by":"publisher","first-page":"15582","DOI":"10.1128\/JVI.79.24.15582-15585.2005","volume":"79","author":"C Schlieker","year":"2005","unstructured":"Schlieker C, et al. A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae. J Virol. 2005;79(24):15582\u20135.","journal-title":"J Virol"}],"container-title":["Mycopathologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-019-00384-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11046-019-00384-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-019-00384-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T02:35:45Z","timestamp":1664418945000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11046-019-00384-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,19]]},"references-count":34,"alternative-id":["384"],"URL":"https:\/\/doi.org\/10.1007\/s11046-019-00384-1","relation":{},"ISSN":["0301-486X","1573-0832"],"issn-type":[{"value":"0301-486X","type":"print"},{"value":"1573-0832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,19]]},"assertion":[{"value":"9 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing financial interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}