{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:32:59Z","timestamp":1791495179077,"version":"4.3.4"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81671410"],"award-info":[{"award-number":["81671410"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100019349","name":"Nanjing Medical Science and Technique Development Foundation","doi-asserted-by":"crossref","award":["QRX17072"],"award-info":[{"award-number":["QRX17072"]}],"id":[{"id":"10.13039\/501100019349","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071602"],"award-info":[{"award-number":["82071602"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073392"],"award-info":[{"award-number":["82073392"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mycopathologia"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vulvovaginal candidiasis (VVC) caused by <jats:italic>Candida spp.<\/jats:italic> affects 70\u201375% of women at least once during their lives. We aim to elucidate the potential mechanism of VVC and investigate the therapeutic effects of long noncoding RNA 9708-1. Female BALB\/c mice were randomized to four treatment groups, including the blank control group, VVC control group, vehicle control group and lncRNA 9708-1-overexpressed group. Mice were euthanized on Day\u00a04, Day\u00a07 and Day\u00a014 after treatment. Colony-forming unit (CFU) was measured, and the inflammation was detected by hematoxylin and eosin (H&amp;E). Gene and protein expression levels of lncRNA 9708-1 and FAK were determined by real-time PCR, Western blot and immunohistochemistry. The overexpression of lncRNA 9708-1 significantly decreased the fungal load from Day 4 to 7. H&amp;E staining indicated that the impaired histological profiles were improved in lncRNA 9708-1-overexpressed group. LncRNA 9708-1 led to a significant increase in FAK level of vagina tissue which is expressed mainly in epithelial basal layer. This study suggests that lncRNA 9708-1 played a protective role on murine experimental VVC by upregulating the expression levels of FAK.<\/jats:p>","DOI":"10.1007\/s11046-021-00530-8","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T12:48:16Z","timestamp":1626353296000},"page":"177-188","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antifungal Effect of Long Noncoding RNA 9708-1 in the Vulvovaginal Candidiasis Murine Model"],"prefix":"10.1007","volume":"186","author":[{"given":"Ying","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Luan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Rui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1264-9910","authenticated-orcid":false,"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"key":"530_CR1","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1080\/13693780701218689","volume":"45","author":"J Perlroth","year":"2007","unstructured":"Perlroth J, Choi B, Spellberg B. Nosocomial fungal infections: epidemiology, diagnosis, and treatment. Med Mycol. 2007;45:321\u201346. https:\/\/doi.org\/10.1080\/13693780701218689.","journal-title":"Med Mycol"},{"key":"530_CR2","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1136\/pgmj.55.647.645","volume":"55","author":"R Hurley","year":"1979","unstructured":"Hurley R, De Louvois J. Candida vaginitis. Postgrad Med J. 1979;55:645\u20137. https:\/\/doi.org\/10.1136\/pgmj.55.647.645.","journal-title":"Postgrad Med J"},{"key":"530_CR3","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/j.1365-2249.2005.02891.x","volume":"142","author":"NA Neves","year":"2005","unstructured":"Neves NA, Carvalho LP, De Oliveira MA, Giraldo PC, Bacellar O, Cruz AA, et al. Association between atopy and recurrent vaginal candidiasis. Clin Exp Immunol. 2005;142:167\u201371. https:\/\/doi.org\/10.1111\/j.1365-2249.2005.02891.x.","journal-title":"Clin Exp Immunol"},{"key":"530_CR4","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.1001\/jama.1987.03390220103029","volume":"257","author":"JL Rhoads","year":"1987","unstructured":"Rhoads JL, Wright DC, Redfield RR, Burke DS. Chronic vaginal candidiasis in women with human immunodeficiency virus infection. JAMA. 1987;257:3105\u20137.","journal-title":"JAMA"},{"key":"530_CR5","doi-asserted-by":"publisher","first-page":"730","DOI":"10.3760\/cma.j.issn.0529-567X.2016.10.004","volume":"51","author":"LT Meng","year":"2016","unstructured":"Meng LT, Xue Y, Yue T, Yang L, Gao L, An RF. Relationship of HPV infection and BV, VVC, TV: a clinical study based on 1 261 cases of gynecologic outpatients. Zhonghua Fu Chan Ke Za Zhi. 2016;51:730\u20133. https:\/\/doi.org\/10.3760\/cma.j.issn.0529-567X.2016.10.004.","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"530_CR6","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1055\/s-0035-1545909","volume":"75","author":"W Frobenius","year":"2015","unstructured":"Frobenius W, Bogdan C. Diagnostic value of vaginal discharge, wet mount and vaginal pH \u2013 an update on the basics of gynecologic infectiology. Geburtshilfe Frauenheilkd. 2015;75:355\u201366. https:\/\/doi.org\/10.1055\/s-0035-1545909.","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"530_CR7","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1128\/CMR.00076-09","volume":"23","author":"JM Achkar","year":"2010","unstructured":"Achkar JM, Fries BC. Candida infections of the genitourinary tract. Clin Microbiol Rev. 2010;23:253\u201373. https:\/\/doi.org\/10.1128\/CMR.00076-09.","journal-title":"Clin Microbiol Rev"},{"key":"530_CR8","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.tig.2019.01.005","volume":"35","author":"M Legrand","year":"2019","unstructured":"Legrand M, Jaitly P, Feri A, d\u2019Enfert C, Sanyal K. Candida albicans: an emerging yeast model to study eukaryotic genome plasticity. Trends Genet. 2019;35:292\u2013307. https:\/\/doi.org\/10.1016\/j.tig.2019.01.005.","journal-title":"Trends Genet"},{"key":"530_CR9","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/s0074-7696(02)20005-4","volume":"220","author":"SK Alahari","year":"2002","unstructured":"Alahari SK, Reddig PJ, Juliano RL. Biological aspects of signal transduction by cell adhesion receptors. Int Rev Cytol. 2002;220:145\u201384. https:\/\/doi.org\/10.1016\/s0074-7696(02)20005-4.","journal-title":"Int Rev Cytol"},{"key":"530_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11046-008-9142-z","volume":"167","author":"J Shi","year":"2009","unstructured":"Shi J, Zeng X, Zhou M, Chen Q. Activation of ERK-FAK signaling pathway and enhancement of cell migration involved in the early interaction between oral keratinocytes and Candida albicans. Mycopathologia. 2009;167:1\u20137. https:\/\/doi.org\/10.1007\/s11046-008-9142-z.","journal-title":"Mycopathologia"},{"key":"530_CR11","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1126\/science.1092053","volume":"302","author":"AJ Ridley","year":"2003","unstructured":"Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, et al. Cell migration: integrating signals from front to back. Science. 2003;302:1704\u20139. https:\/\/doi.org\/10.1126\/science.1092053.","journal-title":"Science"},{"key":"530_CR12","doi-asserted-by":"publisher","first-page":"E97","DOI":"10.1038\/ncb0402-e97","volume":"4","author":"DJ Webb","year":"2002","unstructured":"Webb DJ, Parsons JT, Horwitz AF. Adhesion assembly, disassembly and turnover in migrating cells \u2013 over and over and over again. Nat Cell Biol. 2002;4:E97-100. https:\/\/doi.org\/10.1038\/ncb0402-e97.","journal-title":"Nat Cell Biol"},{"key":"530_CR13","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.mib.2006.06.007","volume":"9","author":"J Nett","year":"2006","unstructured":"Nett J, Andes D. Candida albicans biofilm development, modeling a host\u2013pathogen interaction. Curr Opin Microbiol. 2006;9:340\u20135. https:\/\/doi.org\/10.1016\/j.mib.2006.06.007.","journal-title":"Curr Opin Microbiol"},{"key":"530_CR14","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.tplants.2011.10.008","volume":"17","author":"E-D Kim","year":"2012","unstructured":"Kim E-D, Sung S. Long noncoding RNA: unveiling hidden layer of gene regulatory networks. Trends Plant Sci. 2012;17:16\u201321. https:\/\/doi.org\/10.1016\/j.tplants.2011.10.008.","journal-title":"Trends Plant Sci"},{"key":"530_CR15","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13036.10.1111\/cmi.13036","author":"M Maarouf","year":"2019","unstructured":"Maarouf M, Chen B, Chen Y, Wang X, Rai KR, Zhao Z, et al. Identification of lncRNA-155 encoded by MIR155HG as a novel regulator of innate immunity against influenza a virus infection. Cell Microbiol. 2019. https:\/\/doi.org\/10.1111\/cmi.13036.10.1111\/cmi.13036.","journal-title":"Cell Microbiol"},{"key":"530_CR16","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.29008.10.1002\/jcb.29008","author":"L Song","year":"2019","unstructured":"Song L, Xie H, Tong F, Yan B, Zhang S, Fu E, et al. Association of lnc-IL17RA-11 with increased radiation sensitivity and improved prognosis of HPV-positive HNSCC. J Cell Biochem. 2019. https:\/\/doi.org\/10.1002\/jcb.29008.10.1002\/jcb.29008.","journal-title":"J Cell Biochem"},{"key":"530_CR17","doi-asserted-by":"publisher","first-page":"40598","DOI":"10.1038\/srep40598","volume":"7","author":"K Riege","year":"2017","unstructured":"Riege K, Holzer M, Klassert TE, Barth E, Brauer J, Collatz M, et al. Massive effect on LncRNAs in human monocytes during fungal and bacterial infections and in response to vitamins A and D. Sci Rep. 2017;7:40598. https:\/\/doi.org\/10.1038\/srep40598.","journal-title":"Sci Rep"},{"key":"530_CR18","doi-asserted-by":"publisher","unstructured":"Imamura K, Takaya A, Ishida YI, Fukuoka Y, Taya T, Nakaki R, et al. Diminished nuclear RNA descay upon salmonella infection upregulates antibacterial noncoding RNAs. EMBO J 2018. https:\/\/doi.org\/https:\/\/doi.org\/10.15252\/embj.201797723.","DOI":"10.15252\/embj.201797723"},{"key":"530_CR19","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1007\/s10577-013-9393-5","volume":"21","author":"E Hiriart","year":"2013","unstructured":"Hiriart E, Verdel A. Long noncoding RNA-based chromatin control of germ cell differentiation: a yeast perspective. Chromosome Res. 2013;21:653\u201363. https:\/\/doi.org\/10.1007\/s10577-013-9393-5.","journal-title":"Chromosome Res"},{"key":"530_CR20","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1016\/j.cell.2012.06.049","volume":"150","author":"FJ van Werven","year":"2012","unstructured":"van Werven FJ, Neuert G, Hendrick N, Lardenois A, Buratowski S, van Oudenaarden A, et al. Transcription of two long noncoding RNAs mediates mating-type control of gametogenesis in budding yeast. Cell. 2012;150:1170\u201381. https:\/\/doi.org\/10.1016\/j.cell.2012.06.049.","journal-title":"Cell"},{"key":"530_CR21","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s13068-018-1081-4","volume":"11","author":"P Till","year":"2018","unstructured":"Till P, Pucher ME, Mach RL, Mach-Aigner AR. A long noncoding RNA promotes cellulase expression in trichoderma reesei. Biotechnol Biofuels. 2018;11:78. https:\/\/doi.org\/10.1186\/s13068-018-1081-4.","journal-title":"Biotechnol Biofuels"},{"key":"530_CR22","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.tcb.2015.07.002","volume":"25","author":"G Bohmdorfer","year":"2015","unstructured":"Bohmdorfer G, Wierzbicki AT. Control of chromatin structure by long noncoding RNA. Trends Cell Biol. 2015;25:623\u201332. https:\/\/doi.org\/10.1016\/j.tcb.2015.07.002.","journal-title":"Trends Cell Biol"},{"key":"530_CR23","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1038\/s41419-018-0793-5","volume":"9","author":"S Zhang","year":"2018","unstructured":"Zhang S, Ma H, Zhang D, Xie S, Wang W, Li Q, et al. LncRNA KCNQ1OT1 regulates proliferation and cisplatin resistance in tongue cancer via miR-211-5p mediated Ezrin\/Fak\/Src signaling. Cell Death Dis. 2018;9:742. https:\/\/doi.org\/10.1038\/s41419-018-0793-5.","journal-title":"Cell Death Dis"},{"key":"530_CR24","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/s41419-020-2633-7","volume":"11","author":"K Pan","year":"2020","unstructured":"Pan K, Xie Y. LncRNA FOXC2-AS1 enhances FOXC2 mRNA stability to promote colorectal cancer progression via activation of Ca(2+)-FAK signal pathway. Cell Death Dis. 2020;11:434. https:\/\/doi.org\/10.1038\/s41419-020-2633-7.","journal-title":"Cell Death Dis"},{"key":"530_CR25","doi-asserted-by":"publisher","first-page":"170","DOI":"10.3389\/fimmu.2018.00170","volume":"9","author":"TL Croston","year":"2018","unstructured":"Croston TL, Lemons AR, Beezhold DH, Green BJ. MicroRNA regulation of host immune responses following fungal exposure. Front Immunol. 2018;9:170. https:\/\/doi.org\/10.3389\/fimmu.2018.00170.","journal-title":"Front Immunol"},{"key":"530_CR26","first-page":"919","volume":"16","author":"ME Bertholf","year":"1983","unstructured":"Bertholf ME, Stafford MJ. Colonization of Candida albicans in vagina, rectum, and mouth. J Fam Pract. 1983;16:919\u201324.","journal-title":"J Fam Pract"},{"key":"530_CR27","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nature05674","volume":"446","author":"OJ Sansom","year":"2007","unstructured":"Sansom OJ, Meniel VS, Muncan V, Phesse TJ, Wilkins JA, Reed KR, et al. Myc deletion rescues Apc deficiency in the small intestine. Nature. 2007;446:676\u20139. https:\/\/doi.org\/10.1038\/nature05674.","journal-title":"Nature"},{"key":"530_CR28","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.colsurfb.2018.11.011","volume":"174","author":"C Rodriguez-Cerdeira","year":"2019","unstructured":"Rodriguez-Cerdeira C, Gregorio MC, Molares-Vila A, Lopez-Barcenas A, Fabbrocini G, Bardhi B, et al. Biofilms and vulvovaginal candidiasis. Colloids Surf B Biointerfaces. 2019;174:110\u201325. https:\/\/doi.org\/10.1016\/j.colsurfb.2018.11.011.","journal-title":"Colloids Surf B Biointerfaces"},{"key":"530_CR29","doi-asserted-by":"publisher","first-page":"ftw08","DOI":"10.1093\/femspd\/ftw018","volume":"74","author":"C Tsui","year":"2016","unstructured":"Tsui C, Kong EF, Jabra-Rizk MA. Pathogenesis of Candida albicans biofilm. Pathog Dis. 2016;74:ftw08. https:\/\/doi.org\/10.1093\/femspd\/ftw018.","journal-title":"Pathog Dis"},{"key":"530_CR30","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v5i0.22434","author":"DW Williams","year":"2013","unstructured":"Williams DW, Jordan RP, Wei XQ, Alves CT, Wise MP, Wilson MJ, et al. Interactions of Candida albicans with host epithelial surfaces. J Oral Microbiol. 2013. https:\/\/doi.org\/10.3402\/jom.v5i0.22434.","journal-title":"J Oral Microbiol"},{"key":"530_CR31","doi-asserted-by":"publisher","first-page":"528521","DOI":"10.1155\/2012\/528521","volume":"2012","author":"G Ramage","year":"2012","unstructured":"Ramage G, Rajendran R, Sherry L, Williams C. Fungal biofilm resistance. Int J Microbiol. 2012;2012:528521. https:\/\/doi.org\/10.1155\/2012\/528521.","journal-title":"Int J Microbiol"},{"key":"530_CR32","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1093\/cid\/ciy185","volume":"66","author":"JE Edwards Jr","year":"2018","unstructured":"Edwards JE Jr, Schwartz MM, Schmidt CS, Sobel JD, Nyirjesy P, Schodel F, et al. A fungal immunotherapeutic vaccine (NDV-3A) for treatment of recurrent vulvovaginal Candidiasis-a phase 2 randomized, double-blind. Placebo-Controlled Trial Clin Infect Dis. 2018;66:1928\u201336. https:\/\/doi.org\/10.1093\/cid\/ciy185.","journal-title":"Placebo-Controlled Trial Clin Infect Dis"},{"key":"530_CR33","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1093\/cid\/ciy554","volume":"68","author":"JM Marrazzo","year":"2019","unstructured":"Marrazzo JM, Dombrowski JC, Wierzbicki MR, Perlowski C, Pontius A, Dithmer D, et al. Safety and efficacy of a novel vaginal anti-infective, TOL-463, in the treatment of bacterial vaginosis and vulvovaginal candidiasis: a randomized, single-blind, phase 2. Controll Trial Clin Infect Dis. 2019;68:803\u20139. https:\/\/doi.org\/10.1093\/cid\/ciy554.","journal-title":"Controll Trial Clin Infect Dis"},{"key":"530_CR34","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1159\/000494475","volume":"50","author":"J Liu","year":"2018","unstructured":"Liu J, Wang HZ, Sun Y. Inhibition of CXCR4 by microRNA-1192 reduces the activation of Th17 cells and expression of inflammation factors in a mouse model of vulvovaginal candidiasis. Cell Physiol Biochem. 2018;50:893\u2013910. https:\/\/doi.org\/10.1159\/000494475.","journal-title":"Cell Physiol Biochem"},{"key":"530_CR35","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s11046-006-0036-7","volume":"162","author":"EA Lilly","year":"2006","unstructured":"Lilly EA, Leigh JE, Joseph SH, Fidel PL Jr. Candida-induced oral epithelial cell responses. Mycopathologia. 2006;162:25\u201332. https:\/\/doi.org\/10.1007\/s11046-006-0036-7.","journal-title":"Mycopathologia"},{"key":"530_CR36","doi-asserted-by":"publisher","first-page":"3346","DOI":"10.1093\/emboj\/cdg322","volume":"22","author":"BD Cuevas","year":"2003","unstructured":"Cuevas BD, Abell AN, Witowsky JA, Yujiri T, Johnson NL, Kesavan K, et al. MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts. EMBO J. 2003;22:3346\u201355. https:\/\/doi.org\/10.1093\/emboj\/cdg322.","journal-title":"EMBO J"},{"key":"530_CR37","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1385\/IR:21:2-3:293","volume":"21","author":"CR Hauck","year":"2000","unstructured":"Hauck CR, Klingbeil CK, Schlaepfer DD. Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration. Immunol Res. 2000;21:293\u2013303. https:\/\/doi.org\/10.1385\/IR:21:2-3:293.","journal-title":"Immunol Res"},{"key":"530_CR38","doi-asserted-by":"publisher","first-page":"4612","DOI":"10.1158\/0008-5472.CAN-19-0799","volume":"79","author":"ZQ Zheng","year":"2019","unstructured":"Zheng ZQ, Li ZX, Zhou GQ, Lin L, Zhang LL, Lv JW, et al. Long noncoding RNA FAM225A promotes nasopharyngeal carcinoma tumorigenesis and metastasis by acting as ceRNA to sponge miR-590-3p\/miR-1275 and upregulate ITGB3. Cancer Res. 2019;79:4612\u201326. https:\/\/doi.org\/10.1158\/0008-5472.CAN-19-0799.","journal-title":"Cancer Res"},{"key":"530_CR39","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.biopha.2018.08.079","volume":"107","author":"J Bao","year":"2018","unstructured":"Bao J, Chen X, Hou Y, Kang G, Li Q, Xu Y. LncRNA DBH-AS1 facilitates the tumorigenesis of hepatocellular carcinoma by targeting miR-138 via FAK\/Src\/ERK pathway. Biomed Pharmacother. 2018;107:824\u201333. https:\/\/doi.org\/10.1016\/j.biopha.2018.08.079.","journal-title":"Biomed Pharmacother"},{"key":"530_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19071866","author":"M Liu","year":"2018","unstructured":"Liu M, Gou L, Xia J, Wan Q, Jiang Y, Sun S, et al. LncRNA ITGB2-AS1 could promote the migration and invasion of breast cancer cells through up-regulating ITGB2. Int J Mol Sci. 2018. https:\/\/doi.org\/10.3390\/ijms19071866.","journal-title":"Int J Mol Sci"},{"key":"530_CR41","doi-asserted-by":"publisher","DOI":"10.3791\/3382.10.3791\/3382","author":"J Yano","year":"2011","unstructured":"Yano J, Fidel PL Jr. Protocols for vaginal inoculation and sample collection in the experimental mouse model of Candida vaginitis. J Vis Exp. 2011. https:\/\/doi.org\/10.3791\/3382.10.3791\/3382.","journal-title":"J Vis Exp"},{"key":"530_CR42","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s11046-020-00440-1","volume":"185","author":"T Luan","year":"2020","unstructured":"Luan T, Liu X, Mao P, Wang X, Rui C, Yan L, et al. The role of 17beta-estrogen in candida albicans adhesion on human vaginal epithelial cells via FAK phosphorylation. Mycopathologia. 2020;185:425\u201338. https:\/\/doi.org\/10.1007\/s11046-020-00440-1.","journal-title":"Mycopathologia"},{"key":"530_CR43","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s10911-011-9226-0","volume":"16","author":"PJ Keely","year":"2011","unstructured":"Keely PJ. Mechanisms by which the extracellular matrix and integrin signaling act to regulate the switch between tumor suppression and tumor promotion. J Mammary Gland Biol Neoplasia. 2011;16:205\u201319. https:\/\/doi.org\/10.1007\/s10911-011-9226-0.","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"530_CR44","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.chom.2012.01.008","volume":"11","author":"RA Bozym","year":"2012","unstructured":"Bozym RA, Delorme-Axford E, Harris K, Morosky S, Ikizler M, Dermody TS, et al. Focal adhesion kinase is a component of antiviral RIG-I-like receptor signaling. Cell Host Microbe. 2012;11:153\u201366. https:\/\/doi.org\/10.1016\/j.chom.2012.01.008.","journal-title":"Cell Host Microbe"},{"key":"530_CR45","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.bbagen.2015.11.002","volume":"1860","author":"S Juillot","year":"2016","unstructured":"Juillot S, Cott C, Madl J, Claudinon J, van der Velden NS, Kunzler M, et al. Uptake of marasmius oreades agglutinin disrupts integrin-dependent cell adhesion. Biochim Biophys Acta. 2016;1860:392\u2013401. https:\/\/doi.org\/10.1016\/j.bbagen.2015.11.002.","journal-title":"Biochim Biophys Acta"},{"key":"530_CR46","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.it.2019.04.001","volume":"40","author":"F Agliano","year":"2019","unstructured":"Agliano F, Rathinam VA, Medvedev AE, Vanaja SK, Vella AT. Long noncoding RNAs in host-pathogen interactions. Trends Immunol. 2019;40:492\u2013510. https:\/\/doi.org\/10.1016\/j.it.2019.04.001.","journal-title":"Trends Immunol"},{"key":"530_CR47","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1126\/science.aao0409","volume":"358","author":"P Wang","year":"2017","unstructured":"Wang P, Xu J, Wang Y, Cao X. An interferon-independent lncRNA promotes viral replication by modulating cellular metabolism. Science. 2017;358:1051\u20135. https:\/\/doi.org\/10.1126\/science.aao0409.","journal-title":"Science"}],"container-title":["Mycopathologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-021-00530-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11046-021-00530-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-021-00530-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T12:48:21Z","timestamp":1626353301000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11046-021-00530-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,15]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["530"],"URL":"https:\/\/doi.org\/10.1007\/s11046-021-00530-8","relation":{},"ISSN":["0301-486X","1573-0832"],"issn-type":[{"value":"0301-486X","type":"print"},{"value":"1573-0832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,15]]},"assertion":[{"value":"24 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All animal procedures were conducted in conformity with the Guide for the Care and Use of Laboratory Animals published by the U.S. National Institutes of Health (NIH Publication number 85\u201323, revised 1996) and the approved regulations set by the Nanjing Medical University Committee on Care and Use of Animals (permit number IACUC-1904005).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}