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Hence, we recruited a cross-sectional cohort of 9223 Singapore\/Malaysia Chinese adults and assessed their sensitization against <jats:italic>Curvularia lunata<\/jats:italic> allergen using the skin prick test approach. A subset of this cohort (<jats:italic>n<\/jats:italic>\u2009=\u2009254) was also screened for specific Immunoglobulin E (sIgE) titers against a panel of 11 fungal allergens. We found significant association of <jats:italic>Curvularia lunata<\/jats:italic> sensitization with the risk of asthma (OR\u2009=\u20091.66, 95% CI: 1.17\u20132.33<jats:italic>; p<\/jats:italic>\u2009=\u20090.00391) and AR (OR\u2009=\u20091.69, 95% CI: 1.18\u20132.41; <jats:italic>p<\/jats:italic>\u2009=\u20090.00396). Among asthmatic patients (<jats:italic>n<\/jats:italic>\u2009=\u20091680), <jats:italic>Curvularia lunata<\/jats:italic> sensitization also increased frequencies of wheezing symptoms (OR\u2009=\u20091.81, 95% CI: 1.05\u20132.96; <jats:italic>p<\/jats:italic>\u2009=\u20090.0239), general practitioner\/specialist visits (OR\u2009=\u20092.37, 95% CI: 1.13\u20134.61; <jats:italic>p<\/jats:italic>\u2009=\u20090.0157), and other asthma-related exacerbation events (OR\u2009=\u20092.14, 95% CI: 1.04\u20134.10; <jats:italic>p<\/jats:italic>\u2009=\u20090.0289). In our serum cohort, sensitization to <jats:italic>Aspergillus<\/jats:italic> spp. was the most common fungal sensitization, with 23.6% (<jats:italic>n<\/jats:italic>\u2009=\u200960) had a class 3 and above sensitization (positive sensitization; sIgE titers of\u2009&gt;\u20093.5\u00a0kU\/L) against this allergen. Increasing sIgE titer against <jats:italic>Aspergillus<\/jats:italic> spp. was also correlated with increased AR risk and AR-related symptoms. In conclusion, our findings emphasize an important role of fungal sensitization in the manifestations of asthma and AR in the Southeast Asian Chinese population.<\/jats:p>","DOI":"10.1007\/s11046-021-00532-6","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T14:12:34Z","timestamp":1626185554000},"page":"583-588","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Sensitization to Airborne Fungal Allergens Associates with Asthma and Allergic Rhinitis Presentation and Severity in the Singaporean\/Malaysian Population"],"prefix":"10.1007","volume":"186","author":[{"given":"Yang Yie","family":"Sio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sze Lei","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yee-How","family":"Say","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keng Foo","family":"Teh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi Ru","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smyrna Moti Rawanan","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavita","family":"Reginald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1337-5146","authenticated-orcid":false,"given":"Fook Tim","family":"Chew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,13]]},"reference":[{"issue":"86","key":"532_CR1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1398-9995.2007.01620.x","volume":"63","author":"J Bousquet","year":"2008","unstructured":"Bousquet J, et al. 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While in Malaysia, ethical approval was granted from the Scientific and Ethical Review Committee (SERC) of UTAR (Ref-code: U\/SERC\/03\/2016), as well as from the Research Ethics Committee at Sunway University (SU), Malaysia (Ref. code: SUREC 2019\/029). All participants (or parent\/guardian for those below 21\u00a0years) signed informed consent forms, and the study was conducted in accordance with the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}