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We report the case of a 39\u00a0year old woman with a history of intravenous drug use who developed endocarditis with direct examination of the resected valve and vegetation showing the presence of mycelia. Cultures were positive for an\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    of section\n                    <jats:italic>Nigri<\/jats:italic>\n                    , which was subsequently identified as\n                    <jats:italic>Aspergillus tubingensis<\/jats:italic>\n                    by sequencing. The clinical course was favorable following surgery and prolonged antifungal therapy (8\u00a0months in total). Antifungal susceptibility testing showed good in vitro activity of amphotericin B, voriconazole and echinocandins against planktonic cells of this\n                    <jats:italic>A. tubingensis<\/jats:italic>\n                    isolate. However, only amphotericin B displayed significant activity against biofilms. In vitro combinations of voriconazole or amphotericin B with echinocandins did not meet the criteria of synergism. Our review of the literature identified 17 other cases of endocarditis attributed to\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    of section\n                    <jats:italic>Nigri<\/jats:italic>\n                    with an overall mortality rate of 57% (100% in the absence of surgery). Endocarditis caused by\n                    <jats:italic>Aspergillus niger<\/jats:italic>\n                    and related cryptic species are rare events, for which surgical management appears to be crucial for outcome. While amphotericin B was the only antifungal drug displaying significant anti-biofilm activity, the type and duration of antifungal therapy remain to be determined.\n                  <\/jats:p>","DOI":"10.1007\/s11046-022-00621-0","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T02:02:36Z","timestamp":1646877756000},"page":"249-258","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Aspergillus tubingensis Endocarditis: A Case Report and Review of the Literature"],"prefix":"10.1007","volume":"187","author":[{"given":"Tristan","family":"Born","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Aruanno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftheria","family":"Kampouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Mombelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Monney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piergiorgio","family":"Tozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1023-5597","authenticated-orcid":false,"given":"Frederic","family":"Lamoth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"issue":"5","key":"621_CR1","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.jinf.2012.08.003","volume":"65","author":"WJ Steinbach","year":"2012","unstructured":"Steinbach WJ, Marr KA, Anaissie EJ, Azie N, Quan SP, Meier-Kriesche HU, et al. 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Lamoth has received research funding from the Swiss National Science Foundation, the Santos-Suarez Foundation, Novartis, MSD and Pfizer outside of the scope of the present work, and has contributed to advisory boards for Gilead.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable, according to the local ethics requirements about case reports.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Written informed consent was obtained from the patient for the publication of this case report.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}