{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:02:37Z","timestamp":1789470157132,"version":"build-2803163510"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:00:00Z","timestamp":1683590400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:00:00Z","timestamp":1683590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mycopathologia"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fungal keratitis is a severe corneal infection, and the causative fungi include various rare fungal species. Fungal keratitis caused by <jats:italic>Talaromyces<\/jats:italic> species has yet to be reported, and there is no information about this fungus as a cause of keratitis. A 77-year-old man developed fungal keratitis while waiting for a donor cornea due to bullous keratopathy in his left eye. Fungal culture of a corneal scraping grew filamentous fungi, which were morphologically identified as <jats:italic>Paecilomyces<\/jats:italic> species. The corneal infection did not improve after topical administration of 1% voriconazole, and ribosomal DNA sequencing definitively verified the fungus to be <jats:italic>Talaromyces coalescens<\/jats:italic>. The lesion gradually improved after switching to topical 5% natamycin. Antifungal susceptibility tests determined the high minimum inhibitory concentrations of voriconazole to be &gt;\u20098\u00a0\u03bcg\/mL. This is the first report of <jats:italic>Talaromyces<\/jats:italic> fungal keratitis. Clinicians, especially those in ophthalmology, need to be aware of this rare fungus.<\/jats:p>","DOI":"10.1007\/s11046-023-00738-w","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T21:50:12Z","timestamp":1683755412000},"page":"251-254","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Fungal Keratitis Caused by Talaromyces coalescens: A Case Report"],"prefix":"10.1007","volume":"188","author":[{"given":"Daisuke","family":"Todokoro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Miyakubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Makimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Komori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"issue":"3","key":"738_CR1","doi-asserted-by":"publisher","first-page":"e49","DOI":"10.1016\/s1473-3099(20)30448-5","volume":"21","author":"L Brown","year":"2021","unstructured":"Brown L, Leck AK, Gichangi M, Burton MJ, Denning DW. The global incidence and diagnosis of fungal keratitis. Lancet Infect Dis. 2021;21(3):e49\u201357. https:\/\/doi.org\/10.1016\/s1473-3099(20)30448-5.","journal-title":"Lancet Infect Dis"},{"key":"738_CR2","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.ajo.2018.07.040","volume":"195","author":"WB Khor","year":"2018","unstructured":"Khor WB, Prajna VN, Garg P, Mehta JS, Xie L, Liu Z, Padilla MDB, Joo CK, Inoue Y, Goseyarakwong P, Hu FR, Nishida K, Kinoshita S, Puangsricharern V, Tan AL, Beuerman R, Young A, Sharma N, Haaland B, Mah FS, Tu EY, Stapleton FJ, Abbott RL, Tan DT. The Asia Cornea Society Infectious Keratitis Study: a prospective multicenter study of infectious Keratitis in Asia. Am J Ophthalmol. 2018;195:161\u201370. https:\/\/doi.org\/10.1016\/j.ajo.2018.07.040.","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"738_CR3","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s10384-022-00904-5","volume":"66","author":"Y Inoue","year":"2022","unstructured":"Inoue Y, Ohashi Y, Shimomura Y, Sotozono C, Hatano H, Fukuda M, Eguchi H, Araki-Sasaki K, Suzuki T, Hoshi S, Asari S, Sunada A, Kimura K, Yaguchi T, Makimura K. Multicenter prospective observational study of fungal keratitis in Japan: analyses of culture-positive cases. Jpn J Ophthalmol. 2022;66(3):227\u201339. https:\/\/doi.org\/10.1007\/s10384-022-00904-5.","journal-title":"Jpn J Ophthalmol"},{"issue":"1","key":"738_CR4","doi-asserted-by":"publisher","first-page":"159","DOI":"10.3114\/sim.2011.70.04","volume":"70","author":"RA Samson","year":"2011","unstructured":"Samson RA, Yilmaz N, Houbraken J, Spierenburg H, Seifert KA, Peterson SW, Varga J, Frisvad JC. Phylogeny and nomenclature of the genus Talaromyces and taxa accommodated in Penicillium subgenus Biverticillium. Stud Mycol. 2011;70(1):159\u201383. https:\/\/doi.org\/10.3114\/sim.2011.70.04.","journal-title":"Stud Mycol"},{"issue":"5","key":"738_CR5","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.jcjo.2016.05.013","volume":"51","author":"R Chew","year":"2016","unstructured":"Chew R, Dorman A, Woods ML. Purpureocillium lilacinum keratitis: a case series and review of the literature. Can J Ophthalmol. 2016;51(5):382\u20135. https:\/\/doi.org\/10.1016\/j.jcjo.2016.05.013.","journal-title":"Can J Ophthalmol"},{"issue":"5","key":"738_CR6","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1007\/s10792-014-9965-1","volume":"34","author":"D Todokoro","year":"2014","unstructured":"Todokoro D, Yamada N, Fukuchi M, Kishi S. Topical voriconazole therapy of Purpureocillium lilacinum keratitis that occurred in disposable soft contact lens wearers. Int Ophthalmol. 2014;34(5):1159\u201363. https:\/\/doi.org\/10.1007\/s10792-014-9965-1.","journal-title":"Int Ophthalmol"}],"container-title":["Mycopathologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-023-00738-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11046-023-00738-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-023-00738-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T16:22:27Z","timestamp":1687969347000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11046-023-00738-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,9]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["738"],"URL":"https:\/\/doi.org\/10.1007\/s11046-023-00738-w","relation":{},"ISSN":["0301-486X","1573-0832"],"issn-type":[{"value":"0301-486X","type":"print"},{"value":"1573-0832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,9]]},"assertion":[{"value":"14 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Written informed consent was obtained from the patient.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publish"}},{"value":"This study was an observational study. The Institutional Review Board of Gunma University Graduate School of Medicine confirmed that no ethical approval was required.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}