{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:54:23Z","timestamp":1791561263709,"version":"4.3.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mycopathologia"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1007\/s11046-023-00758-6","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T15:02:22Z","timestamp":1686322942000},"page":"371-381","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Incidence of Invasive Infections Among Hemato-Oncology Patients with Significant Burden of Candida in Stool"],"prefix":"10.1007","volume":"188","author":[{"given":"Ron","family":"Edri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matan J.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danna","family":"Dror","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3276-0963","authenticated-orcid":false,"given":"Maya","family":"Korem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"758_CR1","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1093\/cid\/civ933","volume":"62","author":"PG Pappas","year":"2016","unstructured":"Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, Reboli AC, Schuster MG, Vazquez JA, Walsh TJ, Zaoutis TE, Sobel JD. Clinical practice guideline for the management of Candidiasis: 2016 update by the infectious diseases society of America. Clin Infect Dis. 2016;62:e1-50.","journal-title":"Clin Infect Dis."},{"key":"758_CR2","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1056\/NEJMra1315399","volume":"373","author":"BJ Kullberg","year":"2015","unstructured":"Kullberg BJ, Arendrup MC. Invasive candidiasis. N Engl J Med. 2015;373:1445\u201356. https:\/\/doi.org\/10.1056\/NEJMra1315399.","journal-title":"N Engl J Med"},{"key":"758_CR3","doi-asserted-by":"publisher","first-page":"e449","DOI":"10.1093\/cid\/ciaa193","volume":"71","author":"SV Tsay","year":"2020","unstructured":"Tsay SV, Mu Y, Williams S, Epson E, Nadle J, Bamberg WM, Barter DM, Johnston HL, Farley MM, Harb S, Thomas S, Bonner LA, Harrison LH, Hollick R, Marceaux K, Mody RK, Pattee B, Davis SS, Phipps E, Tesini BL, Gellert AB, Zhang AY, Schaffner W, Hillis S, Ndi D, Graber CR, Jackson BR, Chiller T, Magill S, Vallabhaneni S. Burden of Candidemia in the United States, 2017. Clin Infect Dis. 2020;71:e449-453. https:\/\/doi.org\/10.1093\/cid\/ciaa193.","journal-title":"Clin Infect Dis"},{"key":"758_CR4","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1086\/323759","volume":"33","author":"M Nucci","year":"2001","unstructured":"Nucci M, Anaissie E. Revisiting the source of candidemia: Skin or gut? Clin Infect Dis. 2001;33:1959\u201367. https:\/\/doi.org\/10.1086\/323759.","journal-title":"Clin Infect Dis"},{"key":"758_CR5","doi-asserted-by":"publisher","first-page":"e000992","DOI":"10.1136\/bmjopen-2012-000992","volume":"2","author":"LDN Miranda","year":"2012","unstructured":"Miranda LDN, Rodrigues ECA, Costa SF, van der Heijden IM, Dantas KC, Lobo RD, Basso M, Varkulja GF, Krebs VL, Gibelli MA, Criado PR, Levin AS. Candida parapsilosis candidaemia in a neonatal unit over 7 years: a case series study. BMJ Open. 2012;2:e000992. https:\/\/doi.org\/10.1136\/bmjopen-2012-000992.","journal-title":"BMJ Open"},{"key":"758_CR6","doi-asserted-by":"publisher","first-page":"3300","DOI":"10.1128\/JCM.00179-11","volume":"49","author":"MC Arendrup","year":"2011","unstructured":"Arendrup MC, Sulim S, Holm A, Nielsen L, Nielsen SD, Knudsen JD, Drenck NE, Christensen JJ, Johansen HK. Diagnostic issues, clinical characteristics, and outcomes for patients with Fungemia. J ClinMicrobiol. 2011;49:3300\u20138. https:\/\/doi.org\/10.1128\/JCM.00179-11.","journal-title":"J ClinMicrobiol"},{"issue":"9","key":"758_CR7","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1007\/s00134-014-3408-3","volume":"40","author":"O Lortholary","year":"2014","unstructured":"Lortholary O, Renaudat C, Sitbon K, Madec Y, Denoeud-Ndam L, Wolff M, Fontanet A, Bretagne S, Dromer F. Worrisome trends in incidence and mortality of candidemia in intensive care units (Paris area, 2002\u20132010). Intens Care Med. 2014;40(9):1303\u201312. https:\/\/doi.org\/10.1007\/s00134-014-3408-3.","journal-title":"Intens Care Med"},{"key":"758_CR8","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1128\/CMR.00029-06","volume":"20","author":"MA Pfaller","year":"2007","unstructured":"Pfaller MA, Diekema DJ. Epidemiology of Invasive candidiasis: a persistent public health problem. Clin Microbio Rev. 2007;20:133\u201363. https:\/\/doi.org\/10.1128\/CMR.00029-06.","journal-title":"Clin Microbio Rev"},{"key":"758_CR9","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1093\/clinids\/13.2.211","volume":"13","author":"HM Richet","year":"1991","unstructured":"Richet HM, Andremont A, Tancrede C, Pico JL, Jarvis WR. Risk factors for candidemia in patients with acute lymphocytic Leukemia. Rev Infect Dis. 1991;13:211\u20135. https:\/\/doi.org\/10.1093\/clinids\/13.2.211.","journal-title":"Rev Infect Dis"},{"key":"758_CR10","unstructured":"Dzhavadov SS, Sule\u012dmanova TK. [Collonization of intestinal tract of leukaemia patients with Candida and development of systemic candidemia]. Georgian Med News 2009;61\u20133."},{"key":"758_CR11","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1093\/clinids\/20.6.1526","volume":"20","author":"WR Jarvis","year":"1995","unstructured":"Jarvis WR. Epidemiology of nosocomial fungal infections, with emphasis on Candida species. Clin Infect Dis. 1995;20:1526\u201330. https:\/\/doi.org\/10.1093\/clinids\/20.6.1526.","journal-title":"Clin Infect Dis"},{"key":"758_CR12","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","volume":"40","author":"ME Charlson","year":"1987","unstructured":"Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chron Dis. 1987;40:373\u201383. https:\/\/doi.org\/10.1016\/0021-9681(87)90171-8.","journal-title":"J Chron Dis"},{"key":"758_CR13","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/1472-6963-9-129","volume":"9","author":"S Quach","year":"2009","unstructured":"Quach S, Hennessy DA, Faris P, Fong A, Quan H, Doig C. A comparison between the APACHE II and Charlson index score for predicting hospital mortality in critically ill patients. BMC Health Serv Res. 2009;9:129. https:\/\/doi.org\/10.1186\/1472-6963-9-129.","journal-title":"BMC Health Serv Res"},{"key":"758_CR14","doi-asserted-by":"publisher","first-page":"825","DOI":"10.7326\/0003-4819-158-11-201306040-00007","volume":"158","author":"PE Stevens","year":"2013","unstructured":"Stevens PE, Levin A. Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline. Ann Intern Med. 2013;158:825\u201330. https:\/\/doi.org\/10.7326\/0003-4819-158-11-201306040-00007.","journal-title":"Ann Intern Med"},{"key":"758_CR15","doi-asserted-by":"publisher","first-page":"352","DOI":"10.3389\/fcimb.2019.00352","volume":"9","author":"S Israel","year":"2019","unstructured":"Israel S, Amit S, Israel A, Livneh A, Nir-Paz R, Korem M. The epidemiology and susceptibility of Candidemia in Jerusalem Israel. Front Cell Infect Microbiol. 2019;9:352.","journal-title":"Front Cell Infect Microbiol"},{"key":"758_CR16","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1182\/blood-2016-08-733196","volume":"129","author":"H D\u00f6hner","year":"2017","unstructured":"D\u00f6hner H, Estey E, Grimwade D, Amadori S, Appelbaum FR, B\u00fcchner T, Dombret H, Ebert BL, Fenaux P, Larson RA, Levine RL, Lo-Coco F, Naoe T, Niederwieser D, Ossenkoppele GJ, Sanz M, Sierra J, Tallman MS, Tien HF, Wei AH, Lowenberg B, Bloomfield CD. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017;129:424\u201347. https:\/\/doi.org\/10.1182\/blood-2016-08-733196.","journal-title":"Blood"},{"key":"758_CR17","doi-asserted-by":"publisher","first-page":"v111","DOI":"10.1093\/annonc\/mdw325","volume":"27","author":"J Klastersky","year":"2016","unstructured":"Klastersky J, de Naurois J, Rolston K, Rapoport B, Maschmeyer G, Aapro M, Herrstedt J. Management of febrile neutropaenia: ESMO clinical practice guidelines. Ann Oncol. 2016;27:v111\u20138. https:\/\/doi.org\/10.1093\/annonc\/mdw325.","journal-title":"Ann Oncol"},{"issue":"4","key":"758_CR18","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1093\/cid\/cir073","volume":"52","author":"AG Freifeld","year":"2011","unstructured":"Freifeld AG, Bow EJ, Sepkowitz KA, Boeckh MJ, Ito JI, Mullen CA, Wingard JR. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of America. Clin Infect Dis. 2011;52(4):e56\u201393. https:\/\/doi.org\/10.1093\/cid\/cir073.","journal-title":"Clin Infect Dis"},{"issue":"9","key":"758_CR19","doi-asserted-by":"publisher","first-page":"8872","DOI":"10.1038\/s41598-019-45467-7","volume":"20","author":"J Guinan","year":"2019","unstructured":"Guinan J, Wang S, Hazbun TR, Yadav H, Thangamani S. Antibiotic-induced decreases in the levels of microbial-derived short-chain fatty acids correlate with increased gastrointestinal colonization of Candida albicans. Sci Rep. 2019;20(9):8872. https:\/\/doi.org\/10.1038\/s41598-019-45467-7.","journal-title":"Sci Rep"},{"key":"758_CR20","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1128\/AAC.31.2.202","volume":"31","author":"M Giuliano","year":"1987","unstructured":"Giuliano M, Barza M, Jacobus NV, Gorbach SL. Effect of broad-spectrum parenteral antibiotics on composition of intestinal microflora of humans. Antimicrob Agents Chemother. 1987;31:202\u20136. https:\/\/doi.org\/10.1128\/AAC.31.2.202.","journal-title":"Antimicrob Agents Chemother"},{"key":"758_CR21","doi-asserted-by":"publisher","first-page":"e13186","DOI":"10.1111\/tid.13186","volume":"21","author":"WV Kern","year":"2019","unstructured":"Kern WV, Roth JA, Bertz H, G\u00f6tting T, Dettenkofer M, Widmer AF, Theilacker C. Contribution of specific pathogens to bloodstream infection mortality in neutropenic patients with hematologic malignancies: results from a multicentric surveillance cohort study. Transpl Infect Dis. 2019;21:e13186. https:\/\/doi.org\/10.1111\/tid.13186.","journal-title":"Transpl Infect Dis"},{"key":"758_CR22","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/s41591-019-0709-7","volume":"26","author":"B Zhai","year":"2020","unstructured":"Zhai B, Ola M, Rolling T, Tosini NL, Joshowitz S, Littmann ER, Amoretti LA, Fontana E, Wright RJ, Miranda E, Veelken CA, Morjaria SM, Peled JU, van den Brink MRM, Babady NE, Butler G, Taur Y, Hohl TM. High-resolution mycobiota analysis reveals dynamic intestinal translocation preceding invasive candidiasis. Nat Med. 2020;26:59\u201364. https:\/\/doi.org\/10.1038\/s41591-019-0709-7.","journal-title":"Nat Med"},{"key":"758_CR23","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1007\/s11684-019-0681-0","volume":"13","author":"L Hu","year":"2019","unstructured":"Hu L, Wang Q, Zhang X, Xu L, Wang Y, Yan C, Chen H, Chen Y, Liu K, Wang H, Huang X, Mo X. Positive stool culture could predict the clinical outcomes of haploidentical hematopoietic stem cell transplantation. Front Med. 2019;13:492\u2013503. https:\/\/doi.org\/10.1007\/s11684-019-0681-0.","journal-title":"Front Med"},{"key":"758_CR24","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.mib.2011.07.015","volume":"14","author":"CA Kumamoto","year":"2011","unstructured":"Kumamoto CA. Inflammation and gastrointestinal Candida colonization. Curr Opin Microbiol. 2011;14:386\u201391. https:\/\/doi.org\/10.1016\/j.mib.2011.07.015.","journal-title":"Curr Opin Microbiol"},{"key":"758_CR25","doi-asserted-by":"publisher","first-page":"S40","DOI":"10.1016\/S0140-6736(18)30406-9","volume":"391","author":"S Alyacoubi","year":"2018","unstructured":"Alyacoubi S, Abuowda Y, Albarqouni L, B\u00f6ttcher B, Elessi K. Inpatient management of community-acquired pneumonia at the European Gaza Hospital: a clinical audit. Lancet. 2018;391:S40. https:\/\/doi.org\/10.1016\/S0140-6736(18)30406-9.","journal-title":"Lancet"},{"key":"758_CR26","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1016\/j.burns.2013.04.011","volume":"39","author":"AA Elmanama","year":"2013","unstructured":"Elmanama AA, Laham NAA, Tayh GA. Antimicrobial susceptibility of bacterial isolates from burn units in Gaza. Burns. 2013;39:1612\u20138. https:\/\/doi.org\/10.1016\/j.burns.2013.04.011.","journal-title":"Burns"},{"key":"758_CR27","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1111\/zph.12249","volume":"63","author":"A Abu Taha","year":"2016","unstructured":"Abu Taha A, Abu-Zaydeh AH, Ardah RA, Al-Jabi SW, Sweileh WM, Awang R, Zyoud SH. Public knowledge and attitudes regarding the use of antibiotics and resistance: findings from a cross-sectional study among Palestinian adults. Zoonoses Public Health. 2016;63:449\u201357. https:\/\/doi.org\/10.1111\/zph.12249.","journal-title":"Zoonoses Public Health"},{"key":"758_CR28","doi-asserted-by":"publisher","first-page":"e58121","DOI":"10.1371\/journal.pone.0058121","volume":"8","author":"C Huoi","year":"2013","unstructured":"Huoi C, Vanhems P, Nicolle M-C, Michallet M, B\u00e9net T. Incidence of hospital-acquired pneumonia, bacteraemia and urinary tract infections in patients with haematological malignancies, 2004\u20132010: a surveillance-based study. PLoS One. 2013;8:e58121. https:\/\/doi.org\/10.1371\/journal.pone.0058121.","journal-title":"PLoS One"},{"key":"758_CR29","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/cncr.11882","volume":"100","author":"J Crawford","year":"2004","unstructured":"Crawford J, Dale DC, Lyman GH. Chemotherapy-induced neutropenia. Cancer. 2004;100:228\u201337. https:\/\/doi.org\/10.1002\/cncr.11882.","journal-title":"Cancer"},{"key":"758_CR30","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1159\/000085623","volume":"51","author":"F-D Wang","year":"2005","unstructured":"Wang F-D, Lin M-L, Liu C-Y. Bacteremia in patients with hematological malignancies. Chemotherapy. 2005;51:147\u201353. https:\/\/doi.org\/10.1159\/000085623.","journal-title":"Chemotherapy"},{"key":"758_CR31","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1080\/19490976.2018.1465158","volume":"9","author":"L Markey","year":"2018","unstructured":"Markey L, Shaban L, Green ER, Lemon KP, Mecsas J, Kumamoto CA. Pre-colonization with the commensal fungus Candida albicans reduces murine susceptibility to Clostridium difficile infection. Gut Microbes. 2018;9:497\u2013509. https:\/\/doi.org\/10.1080\/19490976.2018.1465158.","journal-title":"Gut Microbes"},{"key":"758_CR32","doi-asserted-by":"publisher","first-page":"e1007056","DOI":"10.1371\/journal.ppat.1007056","volume":"14","author":"P Uppuluri","year":"2018","unstructured":"Uppuluri P, Lin L, Alqarihi A, Luo G, Youssef EG, Alkhazraji S, Yount NY, Ibrahim BA, Bolaris MA, Edwards JE, Swidergall M, Filler SG, Yeaman NY. The Hyr1 protein from the fungus Candida albicans is a cross kingdom immunotherapeutic target for Acinetobacter bacterial infection. PloS Pathog. 2018;14:e1007056. https:\/\/doi.org\/10.1371\/journal.ppat.1007056.","journal-title":"PloS Pathog"},{"key":"758_CR33","doi-asserted-by":"publisher","first-page":"e1009710","DOI":"10.1371\/journal.ppat.1009710","volume":"17","author":"R Alonso-Monge","year":"2021","unstructured":"Alonso-Monge R, Gresnigt MS, Rom\u00e1n E, Hube B, Pla J. Candida albicans colonization of the gastrointestinal tract: a double-edged sword. PloS Pathog. 2021;17:e1009710. https:\/\/doi.org\/10.1371\/journal.ppat.1009710.","journal-title":"PloS Pathog"},{"key":"758_CR34","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/0016-5085(90)90303-I","volume":"98","author":"TP Gupta","year":"1990","unstructured":"Gupta TP, Ehrinpreis MN. Candida-associated diarrhea in hospitalized patients. Gastroenterology. 1990;98:780\u20135. https:\/\/doi.org\/10.1016\/0016-5085(90)90303-I.","journal-title":"Gastroenterology"}],"container-title":["Mycopathologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-023-00758-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11046-023-00758-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-023-00758-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T05:19:39Z","timestamp":1690607979000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11046-023-00758-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,9]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["758"],"URL":"https:\/\/doi.org\/10.1007\/s11046-023-00758-6","relation":{},"ISSN":["0301-486X","1573-0832"],"issn-type":[{"value":"0301-486X","type":"print"},{"value":"1573-0832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,9]]},"assertion":[{"value":"24 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Hadassah Medical Center (HMO-12-0460).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}