{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:21:52Z","timestamp":1792790512299,"version":"4.5.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.966527\/2024-00"],"award-info":[{"award-number":["88887.966527\/2024-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["408540\/2022-2"],"award-info":[{"award-number":["408540\/2022-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Science and Technology INCT Funvir from Brazil","award":["303762\/2020-9"],"award-info":[{"award-number":["303762\/2020-9"]}]},{"DOI":"10.13039\/501100006506","name":"Brazilian Ministry of Health","doi-asserted-by":"crossref","award":["444501\/2023-1"],"award-info":[{"award-number":["444501\/2023-1"]}],"id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CAPES-COFECUB program","award":["C\u00f3digo de Financiamento 001"],"award-info":[{"award-number":["C\u00f3digo de Financiamento 001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mycopathologia"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s11046-025-00969-z","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T23:27:00Z","timestamp":1751585220000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Trichosporon and Antifungal Resistance: Current Knowledge and Gaps"],"prefix":"10.1007","volume":"190","author":[{"given":"Isabela Lima","family":"Miranda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalu Teixeira Aguiar","family":"Peres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Wesley","family":"Bastos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana","family":"Rossato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Morio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1108-5666","authenticated-orcid":false,"given":"Daniel Assis","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"issue":"4","key":"969_CR1","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3314\/mmj.22.004","volume":"63","author":"M Takashima","year":"2022","unstructured":"Takashima M, Sugita T. Taxonomy of Pathogenic Yeasts Candida, Cryptococcus, Malassezia, and Trichosporon. Med Mycol J. 2022;63(4):119\u201332. https:\/\/doi.org\/10.3314\/mmj.22.004.","journal-title":"Med Mycol J"},{"key":"969_CR2","doi-asserted-by":"publisher","unstructured":"Francisco EC, Desnos-Ollivier M, Dieleman C, Boekhout T, Santos DWCL, Medina-Pestana JO, Colombo AL, Hagen F. Unveiling Trichosporon austroamericanum sp. nov.: A Novel Emerging Opportunistic Basidiomycetous Yeast Species. Mycopathologia. 2024 May 6;189(3):43. https:\/\/doi.org\/10.1007\/s11046-024-00851-4.","DOI":"10.1007\/s11046-024-00851-4"},{"key":"969_CR3","doi-asserted-by":"publisher","unstructured":"Aude Commenges, Fran\u00e7oise Coucheney, Marie-H\u00e9l\u00e8ne Lessard, Djamel Drider, Steve Labrie. Trichosporon asahii: Taxonomy, health hazards, and biotechnological applications. Fungal Biology Reviews, Volume 49, 2024, 100369, ISSN 1749\u20134613. https:\/\/doi.org\/10.1016\/j.fbr.2024.100369.","DOI":"10.1016\/j.fbr.2024.100369"},{"key":"969_CR4","doi-asserted-by":"publisher","unstructured":"EC Francisco, JN de Almeida Junior, F de Queiroz Telles, VR Aquino, AVA Mendes, MGM de Andrade Barberino, P de Tarso, O Castro, T Guimar\u00e3es, RC Hahn, ACB Padovan, GM Chaves, AL Colombo. Species distribution and antifungal susceptibility of 358 Trichosporon clinical isolates collected in 24 medical centres. Clinical Microbiology and Infection. Volume 25, Issue 7, 2019, Pages 909.e1\u2013909.e5. 2019 Jul. https:\/\/doi.org\/10.1016\/j.cmi.2019.03.026.","DOI":"10.1016\/j.cmi.2019.03.026"},{"key":"969_CR5","doi-asserted-by":"publisher","unstructured":"Mehta V, Nayyar C, Gulati N, Singla N, Rai S, Chandar J. A Comprehensive Review of Trichosporon spp.: An Invasive and Emerging Fungus. Cureus. 2021 Aug 21;13(8):e17345. https:\/\/doi.org\/10.7759\/cureus.17345.","DOI":"10.7759\/cureus.17345"},{"key":"969_CR6","doi-asserted-by":"publisher","unstructured":"Colombo AL, Padovan AC, Chaves GM. Current knowledge of Trichosporon spp. and Trichosporonosis. Clin Microbiol Rev. 2011 Oct;24(4):682\u2013700. https:\/\/doi.org\/10.1128\/CMR.00003-11.","DOI":"10.1128\/CMR.00003-11"},{"key":"969_CR7","doi-asserted-by":"publisher","unstructured":"Cafarchia C, Camarda A, Romito D, Campolo M, Quaglia NC, Tullio D, Otranto D. Occurrence of yeasts in cloacae of migratory birds. Mycopathologia. 2006\u00aa Apr; 161(4): 229\u2013234. https:\/\/doi.org\/10.1007\/s11046-005-0194-z.","DOI":"10.1007\/s11046-005-0194-z"},{"issue":"7","key":"969_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004982","volume":"11","author":"M Marin\u00e9","year":"2015","unstructured":"Marin\u00e9 M, Brown NA, Ria\u00f1o-Pach\u00f3n DM, Goldman GH. On and Under the Skin: Emerging Basidiomycetous Yeast Infections Caused by Trichosporon Species. PLoS Pathog. 2015;11(7): e1004982. https:\/\/doi.org\/10.1371\/journal.ppat.1004982.","journal-title":"PLoS Pathog"},{"key":"969_CR9","unstructured":"Chander J. Textbook of medical mycology. Chander J (ed): Jaypee Publishers, New Delhi. 2018. https:\/\/books.google.com.au\/books\/about\/Textbook_of_Medical_Mycology.html?id=OLpEDwAAQBAJ&redir_esc=y."},{"key":"969_CR10","doi-asserted-by":"publisher","unstructured":"Singh S, Capoor MR, Varshney S, Gupta DK, Verma PK, Ramesh V. Epidemiology and Antifungal Susceptibility of Infections Caused by Trichosporon Species: An Emerging Non-Candida and Non-Cryptococcus Yeast Worldwide. Indian J Med Microbiol. 2019 Oct-Dec;37, 536\u2013541. https:\/\/doi.org\/10.4103\/ijmm.IJMM_19_146.","DOI":"10.4103\/ijmm.IJMM_19_146"},{"issue":"1","key":"969_CR11","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13668","volume":"67","author":"AE Guerrero-Ponce","year":"2024","unstructured":"Guerrero-Ponce AE, Araiza J, Tirado-S\u00e1nchez A, Bonifaz A. Review Article White Piedra: Review of 131 cases. Mycoses. 2024;67(1): e13668. https:\/\/doi.org\/10.1111\/myc.13668.","journal-title":"Mycoses"},{"issue":"3","key":"969_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2023.116057","volume":"107","author":"P Pumeesat","year":"2023","unstructured":"Pumeesat P, Wongsuk T. Genetic analysis of emerging fungal pathogens: Trichosporon asahii. Diagn Microbiol Infect Dis. 2023;107(3): 116057. https:\/\/doi.org\/10.1016\/j.diagmicrobio.2023.116057.","journal-title":"Diagn Microbiol Infect Dis"},{"key":"969_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2023.e01701","volume":"31","author":"DSJ Chang","year":"2023","unstructured":"Chang DSJ, Harfouch CW, Melendez ML. Trichosporon asahii opportunistic pneumonia after a severe COVID-19 infection. IDCases. 2023;31: e01701. https:\/\/doi.org\/10.1016\/j.idcr.2023.e01701.","journal-title":"IDCases"},{"issue":"4","key":"969_CR14","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s11046-022-00637-6","volume":"187","author":"JL Benelli","year":"2022","unstructured":"Benelli JL, Basso RP, Grafulha TW, Poester VR, Munhoz LS, Martins KB, Zogbi HE, Von Groll A, Severo CB, Stevens DA, Xavier MO. Fungal Bloodstream Co-infection by Trichosporon asahii in a COVID-19 Critical Patient: Case Report and Literature Review. Mycopathologia. 2022;187(4):397\u2013404. https:\/\/doi.org\/10.1007\/s11046-022-00637-6.","journal-title":"Mycopathologia"},{"issue":"2021","key":"969_CR15","doi-asserted-by":"publisher","first-page":"6841393","DOI":"10.1155\/2021\/6841393","volume":"17","author":"V Cronyn","year":"2021","unstructured":"Cronyn V, Howard J, Chiang L, Le L, Tims-Cook Z, Gertz AM. Trichosporon asahii Urinary Tract Infection in a Patient with Severe COVID-19. Case Rep Infect Dis. 2021;17(2021):6841393. https:\/\/doi.org\/10.1155\/2021\/6841393.","journal-title":"Case Rep Infect Dis"},{"key":"969_CR16","doi-asserted-by":"publisher","first-page":"952","DOI":"10.3390\/idr16050076","volume":"16","author":"R Lino","year":"2024","unstructured":"Lino R, Guimar\u00e3es AR, Sousa E, Azevedo M, Santos L. Emerging Fungal Infections of the Central Nervous System in the Past Decade: A Literature Review. Infect Dis Rep. 2024;16:952\u201376. https:\/\/doi.org\/10.3390\/idr16050076.","journal-title":"Infect Dis Rep"},{"key":"969_CR17","doi-asserted-by":"publisher","unstructured":"Dong DV, Boutin S, Sang VV, Manh ND, Hoan NX, Quang HX, Lien TT, Trang VD, The NT, Linh LTK, Schmauder K, Ueltzh\u00f6ffer V, Hafza N, Hauswaldt S, Rupp J, Kremsner PG, Song LH, Nurjadi D, Peter S, Velavan TP. Optimization of the Diagnosis of Central Nervous System Infections in Vietnamese Hospitals: Results From a Retrospective Multicenter Study. Open Forum Infect Dis. 2024 Sep 13;11(9):ofae531. https:\/\/doi.org\/10.1093\/ofid\/ofae531.","DOI":"10.1093\/ofid\/ofae531"},{"issue":"1","key":"969_CR18","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1186\/s12879-018-3363-7","volume":"18","author":"EP Milan","year":"2018","unstructured":"Milan EP, Silva-Rocha WP, de Almeida JJS, Fernandes TUG, de Ara\u00fajo Prudente AL, de Azevedo MF, Francisco EC, de Azevedo Melo AS, Colombo AL, Chaves GM. Trichosporon inkin meningitis in Northeast Brazil: first case report and review of the literature. BMC Infect Dis. 2018;18(1):470. https:\/\/doi.org\/10.1186\/s12879-018-3363-7.","journal-title":"BMC Infect Dis"},{"key":"969_CR19","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s12281-020-00389-0","volume":"14","author":"A Robles-Tenorio","year":"2020","unstructured":"Robles-Tenorio A, Lepe-Moreno KY, Mayorga-Rodr\u00edguez J. White Piedra, a Rare Superficial Mycosis: an Update. Curr Fungal Infect Rep. 2020;14:197\u2013202. https:\/\/doi.org\/10.1007\/s12281-020-00389-0.","journal-title":"Curr Fungal Infect Rep"},{"issue":"11","key":"969_CR20","doi-asserted-by":"publisher","first-page":"4004","DOI":"10.4103\/ijo.IJO_1938_22","volume":"70","author":"S Agrawal","year":"2022","unstructured":"Agrawal S. Spectrum of signs, symptoms, and treatment in amphotericin B-resistant Trichosporon endophthalmitis: A series of ten cases of post-cataract surgery cluster endophthalmitis. Indian J Ophthalmol. 2022;70(11):4004\u20139. https:\/\/doi.org\/10.4103\/ijo.IJO_1938_22.","journal-title":"Indian J Ophthalmol"},{"issue":"12","key":"969_CR21","doi-asserted-by":"publisher","first-page":"e375","DOI":"10.1016\/S1473-3099(21)00203-6","volume":"21","author":"SC Chen","year":"2021","unstructured":"Chen SC, Perfect J, Colombo AL, Cornely OA, Groll AH, Seidel D, Albus K, de Almedia JN, Gilroy G-E, Lass-Fl\u00f6rl C, Ostrosky-Zeichner L, Pagano L, Papp T, Rautemaa-Richardson R, Salmanton-Garc\u00eda J, Spec A, Steinmann J, Arikan-Akdagli S, Arenz DE, Sprute R, Duran-Graeff L, Freiberger T, Girmenia C, Harris M, Kanj SS, Roudbary M, Lortholary O, Meletiadis J, Segal E, Tuon FF, Wiederhold N, Bicanic T, Chander J, Chen YC, Hsueh PR, Ip M, Munoz P, Spriet I, Temfack E, Thompson L, Tortorano AM, Velegraki A, Govender NP. Global guideline for the diagnosis and management of rare yeast infections: an initiative of the ECMM in cooperation with ISHAM and ASM. Lancet Infect Dis. 2021;21(12):e375\u201386. https:\/\/doi.org\/10.1016\/S1473-3099(21)00203-6.","journal-title":"Lancet Infect Dis"},{"issue":"6","key":"969_CR22","doi-asserted-by":"publisher","first-page":"e02615","DOI":"10.1128\/AAC.02615-20","volume":"65","author":"M Desnos-Ollivier","year":"2021","unstructured":"Desnos-Ollivier M, Lortholary O, Bretagne S, Dromer F. Azole Susceptibility Profiles of More than 9,000 Clinical Yeast Isolates Belonging to 40 Common and Rare Species. Antimicrob Agents Chemother. 2021;65(6):e02615-e2620. https:\/\/doi.org\/10.1128\/AAC.02615-20.","journal-title":"Antimicrob Agents Chemother"},{"key":"969_CR23","doi-asserted-by":"publisher","unstructured":"Padovan ACB, Rocha WPDS, Toti ACM, Freitas de Jesus DF, Chaves GM, Colombo AL. Exploring the resistance mechanisms in Trichosporon asahii: Triazoles as the last defense for invasive trichosporonosis. Fungal Genet Biol. 2019 Dec;133:103267. https:\/\/doi.org\/10.1016\/j.fgb.2019.103267.","DOI":"10.1016\/j.fgb.2019.103267"},{"issue":"2","key":"969_CR24","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1080\/08927014.2023.2202315","volume":"39","author":"ALR Aguiar","year":"2023","unstructured":"Aguiar ALR, Silva BND, Fiallos NM, Pereira LMG, Silva ML, Souza PFSM, Portela FVM, Sidrim JJC, Rocha MFG, Castelo-Branco DSCM, Cordeiro RA. Promethazine inhibits efflux, enhances antifungal susceptibility and disrupts biofilm structure and functioning in Trichosporon. Biofouling. 2023;39(2):218\u201330. https:\/\/doi.org\/10.1080\/08927014.2023.2202315.","journal-title":"Biofouling"},{"issue":"10","key":"969_CR25","doi-asserted-by":"publisher","first-page":"8855","DOI":"10.3390\/ijms24108855","volume":"24","author":"X Ma","year":"2023","unstructured":"Ma X, Liu H, Liu Z, Wang Y, Zhong Z, Peng G, Gu Y. Trichosporon asahii PLA2 Gene Enhances Drug Resistance to Azoles by Improving Drug Efflux and Biofilm Formation. Int J Mol Sci. 2023;24(10):8855. https:\/\/doi.org\/10.3390\/ijms24108855.","journal-title":"Int J Mol Sci"},{"issue":"10","key":"969_CR26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0109553","volume":"9","author":"IA Iturrieta-Gonz\u00e1lez","year":"2014","unstructured":"Iturrieta-Gonz\u00e1lez IA, Padovan AC, Bizerra FC, Hahn RC, Colombo AL. Multiple species of Trichosporon produce biofilms highly resistant to triazoles and amphotericin B. PLoS ONE. 2014;9(10): e109553. https:\/\/doi.org\/10.1371\/journal.pone.0109553.","journal-title":"PLoS ONE"},{"key":"969_CR27","doi-asserted-by":"publisher","unstructured":"Guo\u00a0Lyu\u00a0S, Hsueh\u00a0P,\u00a0Al-Hatmi\u00a0AMS, Meis\u00a0JF, Hagen\u00a0F, Xiao\u00a0M, Wang\u00a0H, Barresi\u00a0C,\u00a0Zhou\u00a0MDE, Hoog\u00a0GS,\u00a0Xu\u00a0Y\u00a02019.\u00a0Invasive Infections Due to\u00a0Trichosporon: Species Distribution, Genotyping, and Antifungal Susceptibilities from a Multicenter Study in China. J Clin Microbiol\u00a057:https:\/\/doi.org\/10.1128\/jcm.01505-18.","DOI":"10.1128\/jcm.01505-18"},{"key":"969_CR28","doi-asserted-by":"publisher","unstructured":"Wongsuk T, Boonsilp S, Pumeesat P, Homkaew A, Sangsri T, Chongtrakool P. Genotyping, antifungal susceptibility testing, and biofilm formation of Trichosporon spp. isolated from urine samples in a University Hospital in Bangkok, Thailand. Acta Microbiol Immunol Hung. 2022 Aug 16;69(3):247\u2013257. https:\/\/doi.org\/10.1556\/030.2022.01797.","DOI":"10.1556\/030.2022.01797"},{"issue":"9","key":"969_CR29","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1016\/j.jfma.2020.12.007","volume":"120","author":"SH Kuo","year":"2021","unstructured":"Kuo SH, Lu PL, Chen YC, Ho MW, Lee CH, Chou CH, Lin SY. The epidemiology, genotypes, antifungal susceptibility of Trichosporon species, and the impact of voriconazole on Trichosporon fungemia patients. J Formos Med Assoc. 2021;120(9):1686\u201394. https:\/\/doi.org\/10.1016\/j.jfma.2020.12.007.","journal-title":"J Formos Med Assoc"},{"key":"969_CR30","doi-asserted-by":"publisher","unstructured":"Pereira LMG, Andrade ARC, Portela FVM, Aguiar ALR, Silva BND, Moura SGB, Pergentino MLM, Rocha MFG, Sidrim JJDC, Castelo Branco DSCM, Cordeiro RA. Heterologous extracellular DNA facilitates the development of\u00a0Trichosporon asahii\u00a0and\u00a0T. inkin\u00a0biofilms and enhances their tolerance to antifungals. Biofouling. 2022 Sep;38(8):778\u2013785. https:\/\/doi.org\/10.1080\/08927014.2022.2130788.","DOI":"10.1080\/08927014.2022.2130788"},{"issue":"11","key":"969_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.645812","volume":"22","author":"RA Cordeiro","year":"2021","unstructured":"Cordeiro RA, Aguiar ALR, da Silva BN, Pereira LMG, Portela FVM, de Camargo ZP, de Lima-Neto RG, Castelo-Branco DSCM, Rocha MFG, Sidrim JJC. Trichosporon asahii and Trichosporon inkin Biofilms Produce Antifungal-Tolerant Persister Cells. Front Cell Infect Microbiol. 2021;22(11): 645812. https:\/\/doi.org\/10.3389\/fcimb.2021.645812.","journal-title":"Front Cell Infect Microbiol"},{"key":"969_CR32","doi-asserted-by":"publisher","unstructured":"Flowers\u00a0SA,\u00a0Col\u00f3n\u00a0B,\u00a0Whaley\u00a0SG,\u00a0Schuler\u00a0MA,\u00a0Rogers\u00a0PD.\u00a02015.\u00a0Contribution of Clinically Derived Mutations in\u00a0ERG11\u00a0to Azole Resistance in Candida albicans. Antimicrob Agents Chemother\u00a059. https:\/\/doi.org\/10.1128\/aac.03470-14.","DOI":"10.1128\/aac.03470-14"},{"key":"969_CR33","doi-asserted-by":"publisher","unstructured":"He\u00a0X,\u00a0Li\u00a0S,\u00a0Kaminskyj\u00a0SGW.\u00a02014.\u00a0Using Aspergillus nidulans To Identify Antifungal Drug Resistance Mutations. Eukaryot Cell\u00a013. https:\/\/doi.org\/10.1128\/ec.00334-13.","DOI":"10.1128\/ec.00334-13"},{"key":"969_CR34","doi-asserted-by":"publisher","unstructured":"Abbes S, Sellami H, Neji S, Trabelsi H, Makni F, Ayadi A. Implication of efflux pumps and ERG11 genes in resistance of clinical Trichosporon asahii isolates to fluconazole. J Med Microbiol. 2021 Mar 10;70(3). https:\/\/doi.org\/10.1099\/jmm.0.001236.","DOI":"10.1099\/jmm.0.001236"},{"key":"969_CR35","doi-asserted-by":"publisher","unstructured":"Hisako K, Tokimatsu I, Ishii H, Kawano R, Shirai R, Kishi K, Hiramatsu K, Kadota J. Cloning of the lanosterol 14-\u03b1-demethylase ( ERG11 ) gene in Trichosporon asahii: a possible association between G453R amino acid substitution and azole resistance in T.\u00a0asahii. FEMS Yeast Res. 2012 Sep;12(6):662\u20137. https:\/\/doi.org\/10.1111\/j.1567-1364.2012.00816.x.","DOI":"10.1111\/j.1567-1364.2012.00816.x"},{"key":"969_CR36","doi-asserted-by":"publisher","unstructured":"Nobrega de Almeida J Jr, Jimenez-Ortigosa C, Francisco EC, Colombo AL, Perlin DS.\u00a0ERG11\u00a0Analysis among Clinical Isolates of Trichosporon asahii with Different Azole Susceptibility Profiles. Antimicrob Agents Chemother. 2022 Dec 20;66(12):e0110122. https:\/\/doi.org\/10.1128\/aac.01101-22.","DOI":"10.1128\/aac.01101-22"},{"issue":"11","key":"969_CR37","doi-asserted-by":"publisher","first-page":"2798","DOI":"10.3390\/microorganisms11112798","volume":"11","author":"X Ma","year":"2023","unstructured":"Ma X, Yang W, Yang A, Chen D, Wang C, Ling S, Cao S, Zuo Z, Wang Y, Zhong Z, Peng G, He M, Gu Y. Metabolome and Transcriptome Combinatory Profiling Reveals Fluconazole Resistance Mechanisms of Trichosporon asahii and the Role of Farnesol in Fluconazole Tolerance. Microorganisms. 2023;11(11):2798. https:\/\/doi.org\/10.3390\/microorganisms11112798.","journal-title":"Microorganisms"},{"issue":"4","key":"969_CR38","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3390\/jof6040321","volume":"6","author":"H Carolus","year":"2020","unstructured":"Carolus H, Pierson S, Lagrou K, Van Dijck P. Amphotericin B and Other Polyenes-Discovery, Clinical Use, Mode of Action and Drug Resistance. J Fungi (Basel). 2020;6(4):321. https:\/\/doi.org\/10.3390\/jof6040321.","journal-title":"J Fungi (Basel)"},{"issue":"8","key":"969_CR39","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1093\/jac\/dkt114","volume":"68","author":"Gabriella Freitas Ferreira","year":"2013","unstructured":"Gabriella Freitas Ferreira. Ludmila de Matos Baltazar, Julliana Ribeiro Alves Santos, Andrea Souza Monteiro, Lucia Alves de Oliveira Fraga, Maria Aparecida Resende-Stoianoff, Daniel Assis Santos, The role of oxidative and nitrosative bursts caused by azoles and amphotericin B against the fungal pathogen Cryptococcus gattii. J Antimicrob Chemother. 2013;68(8):1801\u201311. https:\/\/doi.org\/10.1093\/jac\/dkt114.","journal-title":"J Antimicrob Chemother"},{"issue":"1 Suppl","key":"969_CR40","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.amjmed.2011.11.001","volume":"125","author":"MA Pfaller","year":"2012","unstructured":"Pfaller MA. Antifungal drug resistance: mechanisms, epidemiology, and consequences for treatment. Am J Med. 2012;125(1 Suppl):S3-13. https:\/\/doi.org\/10.1016\/j.amjmed.2011.11.001.","journal-title":"Am J Med"},{"issue":"1","key":"969_CR41","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3314\/mmj.23-00009","volume":"65","author":"Y Matsumoto","year":"2024","unstructured":"Matsumoto Y, Arakawa S, Sadahira K, Sato T, Yamazaki K, Nishimoto S. Skin Manifestations of Micafungin Breakthrough Disseminated Trichosporonosis in Acute Megakaryoblastic Leukemia. Med Mycol J. 2024;65(1):17\u201321. https:\/\/doi.org\/10.3314\/mmj.23-00009.","journal-title":"Med Mycol J"},{"issue":"1","key":"969_CR42","doi-asserted-by":"publisher","first-page":"13539","DOI":"10.1038\/s41598-023-40825-y","volume":"13","author":"Y Matsumoto","year":"2023","unstructured":"Matsumoto Y, Sugiyama Y, Nagamachi T, Yoshikawa A, Sugita T. Hog1-mediated stress tolerance in the pathogenic fungus Trichosporon asahii. Sci Rep. 2023;13(1):13539. https:\/\/doi.org\/10.1038\/s41598-023-40825-y.","journal-title":"Sci Rep"},{"issue":"3","key":"969_CR43","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02081-21","volume":"66","author":"M Kimura","year":"2022","unstructured":"Kimura M, Asano-Mori Y, Sakoh T, Abe M, Ueno K, Hoshino Y, Nakamura S, Umeyama T, Yamagoe S, Miyazaki Y, Baba M, Okada C, Ogura S, Mitsuki T, Yamaguchi K, Yuasa M, Kaji D, Kageyama K, Nishida A, Taya Y, Ishiwata K, Takagi S, Yamamoto H, Yamamoto G, Uchida N, Wake A, Taniguchi S, Araoka H. Factors Associated with Breakthrough Fungemia Caused by Candida, Trichosporon, or Fusarium Species in Patients with Hematological Disorders. Antimicrob Agents Chemother. 2022;66(3): e0208121. https:\/\/doi.org\/10.1128\/AAC.02081-21.","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"969_CR44","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s11046-020-00525-x","volume":"186","author":"K Itoh","year":"2021","unstructured":"Itoh K, Iwasaki H, Negoro E, Shigemi H, Tokimatsu I, Tsutani H, Yamauchi T. Successful Treatment of Breakthrough Trichosporon asahii Fungemia by the Combination Therapy of Fluconazole and Liposomal Amphotericin B in a Patient with Follicular Lymphoma. Mycopathologia. 2021;186(1):113\u20137. https:\/\/doi.org\/10.1007\/s11046-020-00525-x.","journal-title":"Mycopathologia"},{"issue":"2","key":"969_CR45","doi-asserted-by":"publisher","first-page":"E31","DOI":"10.3314\/mmj.18.004","volume":"59","author":"Y Hori","year":"2018","unstructured":"Hori Y, Shibuya K. Role of FKS Gene in the Susceptibility of Pathogenic Fungi to Echinocandins. Med Mycol J. 2018;59(2):E31\u201340. https:\/\/doi.org\/10.3314\/mmj.18.004.Erratum.In:MedMycolJ.2018;59(4):J72.doi:10.3314\/mmj.18.004E.","journal-title":"Med Mycol J"},{"issue":"11","key":"969_CR46","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1093\/jac\/dkt221","volume":"68","author":"A Loyse","year":"2013","unstructured":"Loyse A, Dromer F, Day J, Lortholary O, Harrison TS. Flucytosine and cryptococcosis: time to urgently address the worldwide accessibility of a 50-year-old antifungal. J Antimicrob Chemother. 2013;68(11):2435\u201344. https:\/\/doi.org\/10.1093\/jac\/dkt221.","journal-title":"J Antimicrob Chemother"},{"issue":"2\u20133","key":"969_CR47","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s11046-011-9478-7","volume":"173","author":"Z Xia","year":"2012","unstructured":"Xia Z, Yang R, Wang W, Cong L. Genotyping and antifungal drug susceptibility of Trichosporon asahii isolated from Chinese patients. Mycopathologia. 2012;173(2\u20133):127\u201333. https:\/\/doi.org\/10.1007\/s11046-011-9478-7.","journal-title":"Mycopathologia"},{"key":"969_CR48","unstructured":"Tokunaga S, Ohkawa M, Nakashima T, Yamaguchi K, Nishikawa T, Matsushita T, Mikawa I, Hirano S, Kawaguchi S, Miyagi T, et al. Clinical evaluation of flucytosine in patients with urinary fungal infections. Jpn J Antibiot. 1992 Aug;45(8):1060\u20134. Japanese. PMID: 1433895."},{"key":"969_CR49","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1007\/s40265-021-01611-0","volume":"81","author":"M Hoenigl","year":"2021","unstructured":"Hoenigl M, Sprute R, Egger M, et al. The Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin. Drugs. 2021;81:1703\u201329. https:\/\/doi.org\/10.1007\/s40265-021-01611-0.","journal-title":"Drugs"},{"issue":"3","key":"969_CR50","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3390\/jof7030163","volume":"7","author":"S Jallow","year":"2021","unstructured":"Jallow S, Govender NP. Ibrexafungerp: A First-in-Class Oral Triterpenoid Glucan Synthase Inhibitor. J Fungi (Basel). 2021;7(3):163. https:\/\/doi.org\/10.3390\/jof7030163.","journal-title":"J Fungi (Basel)"},{"issue":"2","key":"969_CR51","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01132-23","volume":"68","author":"M Pfaller","year":"2024","unstructured":"Pfaller M, Huband M, Bien PA, Carvalhaes CG, Klauer A, Castanheira M. In vitro activity of manogepix and comparators against infrequently encountered yeast and mold isolates from the SENTRY Surveillance Program (2017\u20132022). Antimicrob Agents Chemother. 2024;68(2): e0113223. https:\/\/doi.org\/10.1128\/aac.01132-23.","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"969_CR52","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00907-23","volume":"11","author":"X Yang","year":"2023","unstructured":"Yang X, Bai S, Wu J, Fan Y, Zou Y, Xia Z, Ao J, Chen T, Zhang M, Yang R. Antifungal Activity and Potential Action Mechanism of Allicin against Trichosporon asahii. Microbiol Spectr. 2023;11(3): e0090723. https:\/\/doi.org\/10.1128\/spectrum.00907-23.","journal-title":"Microbiol Spectr"},{"issue":"6","key":"969_CR53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010537","volume":"18","author":"WB Adisasmito","year":"2022","unstructured":"Adisasmito WB, Almuhairi S, Behravesh CB, Bilivogui P, Bukachi SA, Casas N, Cediel Becerra N, Charron DF, Chaudhary A, Ciacci Zanella JR, Cunningham AA, Dar O, Debnath N, Dungu B, Farag E, Gao GF, Hayman DTS, Khaitsa M, Koopmans MPG, Machalaba C, Mackenzie JS, Markotter W, Mettenleiter TC, Morand S, Smolenskiy V, Zhou L. One Health: A new definition for a sustainable and healthy future. PLoS Pathog. 2022;18(6): e1010537. https:\/\/doi.org\/10.1371\/journal.ppat.1010537.","journal-title":"PLoS Pathog"},{"issue":"3","key":"969_CR54","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/myc.13404","volume":"65","author":"D Castelo-Branco","year":"2022","unstructured":"Castelo-Branco D, Lockhart SR, Chen YC, Santos DA, Hagen F, Hawkins NJ, Lavergne RA, Meis JF, Le Pape P, Rocha MFG, Sidrim JJC, Arendrup M, Morio F. Collateral consequences of agricultural fungicides on pathogenic yeasts: A One Health perspective to tackle azole resistance. Mycoses. 2022;65(3):303\u201311. https:\/\/doi.org\/10.1111\/myc.13404.","journal-title":"Mycoses"},{"issue":"326","key":"969_CR55","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.jhazmat.2016.12.013","volume":"15","author":"J Ren","year":"2017","unstructured":"Ren J, Jin X, Zhang Q, Zheng Y, Lin D, Yu Y. Fungicides induced triazole-resistance in Aspergillus fumigatus associated with mutations of TR46\/Y121F\/T289A and its appearance in agricultural fields. J Hazard Mater. 2017;15(326):54\u201360. https:\/\/doi.org\/10.1016\/j.jhazmat.2016.12.013.","journal-title":"J Hazard Mater"},{"issue":"1","key":"969_CR56","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1093\/mmy\/myz018","volume":"58","author":"HCS Carneiro","year":"2020","unstructured":"Carneiro HCS, Ribeiro NQ, Bastos RW, Santos DA. Effect of non-antifungal agrochemicals on the pathogenic fungus Cryptococcus gattii. Med Mycol. 2020;58(1):47\u201353. https:\/\/doi.org\/10.1093\/mmy\/myz018.","journal-title":"Med Mycol"},{"issue":"681","key":"969_CR57","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.scitotenv.2019.05.094","volume":"1","author":"RW Bastos","year":"2019","unstructured":"Bastos RW, Freitas GJC, Carneiro HCS, Oliveira LVN, Gouveia-Eufrasio L, Santos APN, Moyrand F, Maufrais C, Janbon G, Santos DA. From the environment to the host: How non-azole agrochemical exposure affects the antifungal susceptibility and virulence of Cryptococcus gattii. Sci Total Environ. 2019;1(681):516\u201323. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.05.094.","journal-title":"Sci Total Environ"},{"key":"969_CR58","doi-asserted-by":"publisher","unstructured":"Bastos RW, Carneiro HCS, Oliveira LVN, Rocha KM, Freitas GJC, Costa MC, Magalh\u00e3es TFF, Carvalho VSD, Rocha CE, Ferreira GF, Paix\u00e3o TA, Moyrand F, Janbon G, Santos DA. Environmental Triazole Induces Cross-Resistance to Clinical Drugs and Affects Morphophysiology and Virulence of Cryptococcus gattii and C. neoformans. Antimicrob Agents Chemother. 2017 Dec 21;62(1):e01179\u201317. https:\/\/doi.org\/10.1128\/AAC.01179-17.","DOI":"10.1128\/AAC.01179-17"},{"issue":"12","key":"969_CR59","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1093\/mmy\/myab050","volume":"59","author":"BR Lara","year":"2021","unstructured":"Lara BR, de Camargo BB, Paula CR, Junior DPL, Garces HG, Arnoni MV, Silveira M, Gimenes VMF, Siqueira LPM, Takahashi JPF, Melhem MSC, Richini-Pereira VB, Anversa L, Ruiz LDS. Comparing the phenotypic, genotypic, and proteomic identification of Trichosporon species: A globally emerging yeast of medical importance. Med Mycol. 2021;59(12):1181\u201390. https:\/\/doi.org\/10.1093\/mmy\/myab050.","journal-title":"Med Mycol"},{"issue":"12","key":"969_CR60","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.3390\/jof7121003","volume":"7","author":"C Lo","year":"2021","unstructured":"Lo C, Kang CL, Sun PL, Yu PH, Li WT. Disseminated Fungal Infection and Fungemia Caused by Trichosporon asahii in a Captive Plumed Basilisk (Basiliscus plumifrons). J Fungi (Basel). 2021;7(12):1003. https:\/\/doi.org\/10.3390\/jof7121003.","journal-title":"J Fungi (Basel)"},{"issue":"5","key":"969_CR61","doi-asserted-by":"publisher","first-page":"538","DOI":"10.3390\/pathogens10050538","volume":"10","author":"K Bobrek","year":"2021","unstructured":"Bobrek K, Sok\u00f3\u0142 I, Gawe\u0142 A. Uncommon Non-Candida Yeasts in Healthy Turkeys-Antimicrobial Susceptibility and Biochemical Characteristic of Trichosporon Isolates. Pathogens. 2021;10(5):538. https:\/\/doi.org\/10.3390\/pathogens10050538.","journal-title":"Pathogens"}],"container-title":["Mycopathologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-025-00969-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11046-025-00969-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-025-00969-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T00:39:01Z","timestamp":1757205541000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11046-025-00969-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,4]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["969"],"URL":"https:\/\/doi.org\/10.1007\/s11046-025-00969-z","relation":{},"ISSN":["0301-486X","1573-0832"],"issn-type":[{"value":"0301-486X","type":"print"},{"value":"1573-0832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,4]]},"assertion":[{"value":"15 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"There is no conflict of interest in this work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This work is a review; therefore, an ethical approval statement is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"59"}}