{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:22:02Z","timestamp":1789474922146,"version":"build-2803163510"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Sichuan Science and Technology Program","award":["2025ZNSFSC0602"],"award-info":[{"award-number":["2025ZNSFSC0602"]}]},{"name":"the Technology Strategic Cooperation Project of Luzhou Municipal People\u2019s Government-Southwest Medical University","award":["2023LZXNYDJ034"],"award-info":[{"award-number":["2023LZXNYDJ034"]}]},{"name":"the Technology Strategic Cooperation Project of Pengzhou People's Hospital-Southwest Medical University","award":["2024PZXNYD03"],"award-info":[{"award-number":["2024PZXNYD03"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mycopathologia"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11046-025-01008-7","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T04:16:41Z","timestamp":1759465001000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Character Virulence Association Factors and Gene Mutation Mediating Multidrug Resistance Phenotypes in Candidozyma duobushaemulonii"],"prefix":"10.1007","volume":"190","author":[{"given":"Hao","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1872-9559","authenticated-orcid":false,"given":"Caiyan","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1190-485X","authenticated-orcid":false,"given":"Zhangyong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"1008_CR1","doi-asserted-by":"publisher","first-page":"114960","DOI":"10.1016\/j.addr.2023.114960","volume":"199","author":"H Lu","year":"2023","unstructured":"Lu H, Hong T, Jiang Y, et al. Candidiasis: From cutaneous to systemic, new perspectives of potential targets and therapeutic strategies. Adv Drug Deliv Rev. 2023;199:114960. https:\/\/doi.org\/10.1016\/j.addr.2023.114960.","journal-title":"Adv Drug Deliv Rev"},{"issue":"suppl_3","key":"1008_CR2","doi-asserted-by":"publisher","first-page":"S445","DOI":"10.1093\/infdis\/jix131","volume":"216","author":"MC Arendrup","year":"2017","unstructured":"Arendrup MC, Patterson TF. Multidrug-resistant Candida: epidemiology, molecular mechanisms, and treatment. J Infect Dis. 2017;216(suppl_3):S445\u201351. https:\/\/doi.org\/10.1093\/infdis\/jix131.","journal-title":"J Infect Dis"},{"issue":"12","key":"1008_CR3","doi-asserted-by":"publisher","first-page":"e383","DOI":"10.1016\/S1473-3099(17)30316-X","volume":"17","author":"DS Perlin","year":"2017","unstructured":"Perlin DS, Rautemaa-Richardson R, Alastruey-Izquierdo A. The global problem of antifungal resistance: prevalence, mechanisms, and management. Lancet Infect Dis. 2017;17(12):e383\u201392. https:\/\/doi.org\/10.1016\/S1473-3099(17)30316-X.","journal-title":"Lancet Infect Dis"},{"issue":"11","key":"1008_CR4","doi-asserted-by":"publisher","first-page":"3641","DOI":"10.1128\/JCM.02248-12","volume":"50","author":"E Cendejas-Bueno","year":"2012","unstructured":"Cendejas-Bueno E, Kolecka A, Alastruey-Izquierdo A, et al. Reclassification of the Candida haemulonii complex as Candida haemulonii (C. haemulonii group I), C. duobushaemulonii sp. nov. (C. haemulonii group II), and C. haemulonii var. vulnera var. nov.: three multiresistant human pathogenic yeasts. J Clin Microbiol. 2012;50(11):3641\u201351. https:\/\/doi.org\/10.1128\/JCM.02248-12.","journal-title":"J Clin Microbiol"},{"key":"1008_CR5","doi-asserted-by":"publisher","first-page":"100354","DOI":"10.1016\/j.crmicr.2025.100354","volume":"8","author":"LS Ramos","year":"2025","unstructured":"Ramos LS, Barbosa PF, Lorentino CMA, et al. The multidrug-resistant Candida auris, Candida haemulonii complex and phylogenetic related species: Insights into antifungal resistance mechanisms. Curr Res Microb Sci. 2025;8:100354. https:\/\/doi.org\/10.1016\/j.crmicr.2025.100354.","journal-title":"Curr Res Microb Sci"},{"issue":"1","key":"1008_CR6","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1093\/jac\/dku321","volume":"70","author":"LS Ramos","year":"2015","unstructured":"Ramos LS, Figueiredo-Carvalho MH, Barbedo LS, et al. Candida haemulonii complex: species identification and antifungal susceptibility profiles of clinical isolates from Brazil. J Antimicrob Chemother. 2015;70(1):111\u20135. https:\/\/doi.org\/10.1093\/jac\/dku321.","journal-title":"J Antimicrob Chemother"},{"issue":"6","key":"1008_CR7","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1590\/0074-02760160166","volume":"111","author":"HF Boatto","year":"2016","unstructured":"Boatto HF, Cavalcanti SD, Del Negro GM, et al. Candida duobushaemulonii: an emerging rare pathogenic yeast isolated from recurrent vulvovaginal candidiasis in Brazil. Mem Inst Oswaldo Cruz. 2016;111(6):407\u201310. https:\/\/doi.org\/10.1590\/0074-02760160166.","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"3","key":"1008_CR8","doi-asserted-by":"publisher","first-page":"561","DOI":"10.3201\/eid2203.151610","volume":"22","author":"JN de Almeida","year":"2016","unstructured":"de Almeida JN, Assy JG, Levin AS, et al. Candida haemulonii complex species, Brazil, January 2010-March 2015. Emerg Infect Dis. 2016;22(3):561\u20133. https:\/\/doi.org\/10.3201\/eid2203.151610.","journal-title":"Emerg Infect Dis"},{"issue":"12","key":"1008_CR9","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1111\/myc.12540","volume":"59","author":"SY Fang","year":"2016","unstructured":"Fang SY, Wei KC, Chen WC, et al. Primary deep cutaneous candidiasis caused by Candida duobushaemulonii in a 68-year-old man: the first case report and literature review. Mycoses. 2016;59(12):818\u201321. https:\/\/doi.org\/10.1111\/myc.12540.","journal-title":"Mycoses"},{"issue":"7","key":"1008_CR10","doi-asserted-by":"publisher","first-page":"e00371","DOI":"10.1128\/JCM.00371-18","volume":"56","author":"R Ramos","year":"2018","unstructured":"Ramos R, Caceres DH, Perez M, et al. Emerging multidrug-resistant Candida duobushaemulonii infections in Panama Hospitals: Importance of Laboratory Surveillance and Accurate Identification. J Clin Microbiol. 2018;56(7):e00371-e418. https:\/\/doi.org\/10.1128\/JCM.00371-18.","journal-title":"J Clin Microbiol"},{"key":"1008_CR11","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.2147\/IDR.S402754","volume":"16","author":"M G\u00f3mez-Gaviria","year":"2023","unstructured":"G\u00f3mez-Gaviria M, Mart\u00ednez-\u00c1lvarez JA, Ch\u00e1vez-Santiago JO, et al. Candida haemulonii complex and Candida auris: Biology, virulence factors, immune response, and multidrug resistance. Infect Drug Resist. 2023;16:1455\u201370. https:\/\/doi.org\/10.2147\/IDR.S402754.","journal-title":"Infect Drug Resist"},{"key":"1008_CR12","doi-asserted-by":"publisher","first-page":"e00662","DOI":"10.7554\/eLife.00662","volume":"4","author":"CB Ford","year":"2015","unstructured":"Ford CB, Funt JM, Abbey D, et al. The evolution of drug resistance in clinical isolates of Candida albicans. Elife. 2015;4:e00662. https:\/\/doi.org\/10.7554\/eLife.00662.","journal-title":"Elife"},{"issue":"7591","key":"1008_CR13","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/nature16963","volume":"530","author":"JL Nishikawa","year":"2016","unstructured":"Nishikawa JL, Boeszoermenyi A, Vale-Silva LA, et al. Inhibiting fungal multidrug resistance by disrupting an activator-Mediator interaction. Nature. 2016;530(7591):485\u20139. https:\/\/doi.org\/10.1038\/nature16963.","journal-title":"Nature"},{"issue":"2","key":"1008_CR14","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/nrmicro2475","volume":"9","author":"JS Finkel","year":"2011","unstructured":"Finkel JS, Mitchell AP. Genetic control of Candida albicans biofilm development. Nat Rev Microbiol. 2011;9(2):109\u201318. https:\/\/doi.org\/10.1038\/nrmicro2475.","journal-title":"Nat Rev Microbiol"},{"issue":"22","key":"1008_CR15","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.3390\/cells12222655","volume":"12","author":"KM Czajka","year":"2023","unstructured":"Czajka KM, Venkataraman K, Brabant-Kirwan D, et al. Molecular mechanisms associated with antifungal resistance in pathogenic Candida species. Cells. 2023;12(22):2655. https:\/\/doi.org\/10.3390\/cells12222655.","journal-title":"Cells"},{"issue":"1","key":"1008_CR16","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1093\/clinchem\/hvae185","volume":"71","author":"MC Smithgall","year":"2025","unstructured":"Smithgall MC, Kilic A, Weidmann M, et al. Genetic and phenotypic intra-clade variation in Candida auris isolated from critically ill patients in a New York City Tertiary Care Center. Clin Chem. 2025;71(1):185\u201391. https:\/\/doi.org\/10.1093\/clinchem\/hvae185.","journal-title":"Clin Chem"},{"issue":"4","key":"1008_CR17","doi-asserted-by":"publisher","first-page":"e0240624","DOI":"10.1128\/aem.02406-24","volume":"91","author":"W Xiao","year":"2025","unstructured":"Xiao W, Zhou H, Huang J, et al. Comparative analyses of the biological characteristics, fluconazole resistance, and heat adaptation mechanisms of Candida auris and members of the Candida haemulonii complex. Appl Environ Microbiol. 2025;91(4):e0240624. https:\/\/doi.org\/10.1128\/aem.02406-24.","journal-title":"Appl Environ Microbiol"},{"issue":"8","key":"1008_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed8080382","volume":"8","author":"LS Ramos","year":"2023","unstructured":"Ramos LS, Parra-Giraldo CM, Branquinha MH, et al. Cell aggregation capability of clinical isolates from Candida auris and Candida haemulonii species complex. Trop Med Infect Dis. 2023;8(8):382. https:\/\/doi.org\/10.3390\/tropicalmed8080382.","journal-title":"Trop Med Infect Dis"},{"key":"1008_CR19","doi-asserted-by":"publisher","first-page":"127200","DOI":"10.1016\/j.micres.2022.127200","volume":"265","author":"J Lei","year":"2022","unstructured":"Lei J, Xiao W, Zhang J, et al. Antifungal activity of vitamin D3 against Candida albicans in vitro and in vivo. Microbiol Res. 2022;265:127200.","journal-title":"Microbiol Res"},{"issue":"7","key":"1008_CR20","doi-asserted-by":"publisher","first-page":"772","DOI":"10.3390\/jof9070772","volume":"9","author":"J Huang","year":"2023","unstructured":"Huang J, Lei J, Ge A, et al. Antifungal effect of vitamin D3 against Cryptococcus neoformans coincides with reduced biofilm formation, compromised cell wall integrity, and increased generation of reactive oxygen species. J Fungi. 2023;9(7):772.","journal-title":"J Fungi"},{"key":"1008_CR21","unstructured":"CLSI. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts, CLSI M27 A4, 4th ed.; Clinical and Laboratory Standards Institute: Wayne, PA, USA, 2020."},{"key":"1008_CR22","unstructured":"CLSI. Performance Standard for Antifungal Susceptibility Testing of Yeasts, CLSI M27M44S, 3rd ed.; Clinical and Laboratory Standards Institute: Wayne, PA, USA, 2022."},{"key":"1008_CR23","unstructured":"CLSI. 2017. Performance standards for antifungal susceptibility testing of yeasts: CLSI supplement M60. CLSI, Wayne, PA, USA."},{"key":"1008_CR24","doi-asserted-by":"publisher","first-page":"1253197","DOI":"10.3389\/fmicb.2023.1253197","volume":"14","author":"M Zeng","year":"2023","unstructured":"Zeng M, Zhou X, Yang C, et al. Comparative analysis of the biological characteristics and mechanisms of azole resistance of clinical Aspergillus fumigatus strains. Front Microbiol. 2023;14:1253197. https:\/\/doi.org\/10.3389\/fmicb.2023.1253197.","journal-title":"Front Microbiol"},{"issue":"11","key":"1008_CR25","doi-asserted-by":"publisher","first-page":"909","DOI":"10.3390\/jof7110909","volume":"7","author":"FZ Delma","year":"2021","unstructured":"Delma FZ, Al-Hatmi AMS, Br\u00fcggemann RJM, et al. Molecular mechanisms of 5-fluorocytosine resistance in yeasts and Filamentous Fungi. J Fungi. 2021;7(11):909. https:\/\/doi.org\/10.3390\/jof7110909.","journal-title":"J Fungi"},{"issue":"2","key":"1008_CR26","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1086\/505204","volume":"43","author":"JA Vazquez","year":"2006","unstructured":"Vazquez JA, Sobel JD. Anidulafungin: a novel echinocandin. Clin Infect Dis. 2006;43(2):215\u201322. https:\/\/doi.org\/10.1086\/505204.","journal-title":"Clin Infect Dis"},{"issue":"2","key":"1008_CR27","doi-asserted-by":"publisher","first-page":"e03333","DOI":"10.1128\/mBio.03333-20","volume":"12","author":"H Carolus","year":"2021","unstructured":"Carolus H, Pierson S, Mu\u00f1oz JF, et al. Genome-Wide analysis of experimentally evolved Candida auris reveals multiple novel mechanisms of multidrug resistance. mBio. 2021;12(2):e03333-20. https:\/\/doi.org\/10.1128\/mBio.03333-20.","journal-title":"mBio"},{"issue":"7","key":"1008_CR28","doi-asserted-by":"publisher","first-page":"e0005322","DOI":"10.1128\/aac.00053-22","volume":"66","author":"SE Jacobs","year":"2022","unstructured":"Jacobs SE, Jacobs JL, Dennis EK, et al. Candida auris pan-drug-resistant to four classes of antifungal agents. Antimicrob Agents Chemother. 2022;66(7):e0005322. https:\/\/doi.org\/10.1128\/aac.00053-22.","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"1008_CR29","doi-asserted-by":"publisher","first-page":"e00167","DOI":"10.1128\/mSphere.00167-17","volume":"2","author":"T Weil","year":"2017","unstructured":"Weil T, Santamar\u00eda R, Lee W, et al. Adaptive mistranslation accelerates the evolution of fluconazole resistance and induces major genomic and gene expression alterations in Candida albicans. mSphere. 2017;2(4):e00167-17. https:\/\/doi.org\/10.1128\/mSphere.00167-17.","journal-title":"mSphere"},{"issue":"5","key":"1008_CR30","doi-asserted-by":"publisher","first-page":"e1002718","DOI":"10.1371\/journal.ppat.1002718","volume":"8","author":"SD Singh-Babak","year":"2012","unstructured":"Singh-Babak SD, Babak T, Diezmann S, et al. Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata. PLoS Pathog. 2012;8(5):e1002718. https:\/\/doi.org\/10.1371\/journal.ppat.1002718.","journal-title":"PLoS Pathog"},{"issue":"3","key":"1008_CR31","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3390\/jof4030105","volume":"4","author":"KR Healey","year":"2018","unstructured":"Healey KR, Perlin DS. Fungal resistance to echinocandins and the MDR phenomenon in Candida glabrata. J Fungi (Basel). 2018;4(3):105. https:\/\/doi.org\/10.3390\/jof4030105.","journal-title":"J Fungi (Basel)"},{"issue":"1","key":"1008_CR32","doi-asserted-by":"publisher","first-page":"e0210397","DOI":"10.1371\/journal.pone.0210397","volume":"14","author":"K Spettel","year":"2019","unstructured":"Spettel K, Barousch W, Makristathis A, et al. Analysis of antifungal resistance genes in Candida albicans and Candida glabrata using next generation sequencing. PLoS ONE. 2019;14(1):e0210397. https:\/\/doi.org\/10.1371\/journal.pone.0210397.","journal-title":"PLoS ONE"},{"issue":"1","key":"1008_CR33","doi-asserted-by":"publisher","first-page":"5346","DOI":"10.1038\/s41467-018-07779-6","volume":"9","author":"JF Mu\u00f1oz","year":"2018","unstructured":"Mu\u00f1oz JF, Gade L, Chow NA, et al. Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species. Nat Commun. 2018;9(1):5346. https:\/\/doi.org\/10.1038\/s41467-018-07779-6.","journal-title":"Nat Commun"},{"issue":"3","key":"1008_CR34","doi-asserted-by":"publisher","first-page":"e0209821","DOI":"10.1128\/AAC.02098-21","volume":"66","author":"BG Vu","year":"2022","unstructured":"Vu BG, Moye-Rowley WS. Azole-resistant alleles of ERG11 in Candida glabrata trigger activation of the Pdr1 and Upc2A transcription factors. Antimicrob Agents Chemother. 2022;66(3):e0209821. https:\/\/doi.org\/10.1128\/AAC.02098-21.","journal-title":"Antimicrob Agents Chemother"},{"issue":"7","key":"1008_CR35","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1093\/mmy\/myx005","volume":"55","author":"LS Ramos","year":"2017","unstructured":"Ramos LS, Oliveira SSC, Souto XM, et al. Planktonic growth and biofilm formation profiles in Candida haemulonii species complex. Med Mycol. 2017;55(7):785\u20139. https:\/\/doi.org\/10.1093\/mmy\/myx005.","journal-title":"Med Mycol"},{"issue":"11","key":"1008_CR36","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1111\/myc.12834","volume":"61","author":"A Mart\u00ednez-Murcia","year":"2018","unstructured":"Mart\u00ednez-Murcia A, Navarro A, Bru G, et al. Internal validation of GPS MONODOSE CanAur dtec-qPCR kit following the UNE\/EN ISO\/IEC 17025:2005 for detection of the emerging yeast Candida auris. Mycoses. 2018;61(11):877\u201384. https:\/\/doi.org\/10.1111\/myc.12834.","journal-title":"Mycoses"},{"issue":"4","key":"1008_CR37","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.diagmicrobio.2018.07.005","volume":"92","author":"F Lallitto","year":"2018","unstructured":"Lallitto F, Prigitano A, Mangione F, et al. Presence of L701 M mutation in the FKS1 gene of echinocandin-susceptible Candida krusei isolates. Diagn Microbiol Infect Dis. 2018;92(4):311\u20134. https:\/\/doi.org\/10.1016\/j.diagmicrobio.2018.07.005.","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"5","key":"1008_CR38","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1093\/jac\/dkz565","volume":"75","author":"A Ceballos Garzon","year":"2020","unstructured":"Ceballos Garzon A, Amado D, Robert E, et al. Impact of calmodulin inhibition by fluphenazine on susceptibility, biofilm formation and pathogenicity of caspofungin-resistant Candida glabrata. J Antimicrob Chemother. 2020;75(5):1187\u201393. https:\/\/doi.org\/10.1093\/jac\/dkz565.","journal-title":"J Antimicrob Chemother"},{"issue":"1","key":"1008_CR39","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.1080\/22221751.2022.2117093","volume":"11","author":"F Daneshnia","year":"2022","unstructured":"Daneshnia F, de Almeida J\u00fanior JN, Arastehfar A, et al. Determinants of fluconazole resistance and echinocandin tolerance in C. parapsilosis isolates causing a large clonal candidemia outbreak among COVID-19 patients in a Brazilian ICU. Emerg Microbes Infect. 2022;11(1):2264\u201374. https:\/\/doi.org\/10.1080\/22221751.2022.2117093.","journal-title":"Emerg Microbes Infect"},{"issue":"1","key":"1008_CR40","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1080\/22221751.2019.1684209","volume":"8","author":"X Hou","year":"2019","unstructured":"Hou X, Healey KR, Shor E, et al. Novel FKS1 and FKS2 modifications in a high-level echinocandin resistant clinical isolate of Candida glabrata. Emerg Microbes Infect. 2019;8(1):1619\u201325. https:\/\/doi.org\/10.1080\/22221751.2019.1684209.","journal-title":"Emerg Microbes Infect"},{"issue":"10","key":"1008_CR41","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.2217\/fmb-2018-0059","volume":"13","author":"J Beardsley","year":"2018","unstructured":"Beardsley J, Halliday CL, Chen SC, et al. Responding to the emergence of antifungal drug resistance: perspectives from the bench and the bedside. Future Microbiol. 2018;13(10):1175\u201391. https:\/\/doi.org\/10.2217\/fmb-2018-0059.","journal-title":"Future Microbiol"},{"issue":"6","key":"1008_CR42","doi-asserted-by":"publisher","first-page":"e00547","DOI":"10.1128\/mSphere.00547-18","volume":"3","author":"C Papp","year":"2018","unstructured":"Papp C, Kocsis K, T\u00f3th R, et al. Echinocandin-induced microevolution of Candida parapsilosis influences virulence and abiotic stress tolerance. mSphere. 2018;3(6):e00547. https:\/\/doi.org\/10.1128\/mSphere.00547-18.","journal-title":"mSphere"},{"issue":"4","key":"1008_CR43","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.01767-22","volume":"61","author":"Y Zhu","year":"2023","unstructured":"Zhu Y, Hager KM, Manjari SR, et al. Development and validation of TaqMan chemistry probe-based rapid assay for the detection of echinocandin-resistance in Candida auris. J Clin Microbiol. 2023;61(4):e0176722. https:\/\/doi.org\/10.1128\/jcm.01767-22.","journal-title":"J Clin Microbiol"},{"issue":"7955","key":"1008_CR44","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/s41586-023-05856-5","volume":"616","author":"X Hu","year":"2023","unstructured":"Hu X, Yang P, Chai C, et al. Structural and mechanistic insights into fungal \u03b2-1,3-glucan synthase FKS1. Nature. 2023;616(7955):190\u20138. https:\/\/doi.org\/10.1038\/s41586-023-05856-5.","journal-title":"Nature"},{"key":"1008_CR45","doi-asserted-by":"publisher","DOI":"10.1128\/msphere.00977-24","author":"T Phan-Canh","year":"2025","unstructured":"Phan-Canh T, Nguyen-Le D-M, Luu P-L, Khunweeraphong N, Kuchler K. Rapid in vitro evolution of flucytosine resistance in Candida auris. mSphere. 2025. https:\/\/doi.org\/10.1128\/msphere.00977-24.","journal-title":"mSphere"},{"issue":"9","key":"1008_CR46","doi-asserted-by":"publisher","first-page":"568","DOI":"10.3390\/antibiotics9090568","volume":"9","author":"MG Fr\u00edas-De-Le\u00f3n","year":"2020","unstructured":"Fr\u00edas-De-Le\u00f3n MG, Hern\u00e1ndez-Castro R, Vite-Gar\u00edn T, et al. Antifungal resistance in Candida auris: molecular determinants. Antibiotics. 2020;9(9):568. https:\/\/doi.org\/10.3390\/antibiotics9090568.","journal-title":"Antibiotics"},{"issue":"7","key":"1008_CR47","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1093\/mmy\/myz139","volume":"58","author":"LS Ramos","year":"2020","unstructured":"Ramos LS, Oliveira SSC, Silva LN, et al. Surface, adhesiveness and virulence aspects of Candida haemulonii species complex. Med Mycol. 2020;58(7):973\u201386.","journal-title":"Med Mycol"},{"issue":"12","key":"1008_CR48","doi-asserted-by":"publisher","first-page":"e01412","DOI":"10.1128\/AAC.01412-17","volume":"61","author":"KR Healey","year":"2017","unstructured":"Healey KR, Nagasaki Y, Zimmerman M, et al. The gastrointestinal tract is a major source of echinocandin drug resistance in a murine model of Candida glabrata colonization and systemic dissemination. Antimicrob Agents Chemother. 2017;61(12):e01412-17. https:\/\/doi.org\/10.1128\/AAC.01412-17.","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"1008_CR49","doi-asserted-by":"publisher","first-page":"9099","DOI":"10.1038\/s41598-017-09329-4","volume":"7","author":"A Vella","year":"2017","unstructured":"Vella A, De Carolis E, Mello E, et al. Potential use of MALDI-ToF mass spectrometry for rapid detection of antifungal resistance in the human pathogen Candida glabrata. Sci Rep. 2017;7(1):9099.","journal-title":"Sci Rep"},{"issue":"6","key":"1008_CR50","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1093\/jac\/dky059","volume":"73","author":"TP McCarty","year":"2018","unstructured":"McCarty TP, Lockhart SR, Moser SA, et al. Echinocandin resistance among Candida isolates at an academic medical centre 2005\u201315: analysis of trends and outcomes. J Antimicrob Chemother. 2018;73(6):1677\u201380.","journal-title":"J Antimicrob Chemother"},{"issue":"3","key":"1008_CR51","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s11046-024-00847-0","volume":"189","author":"HO Khalifa","year":"2024","unstructured":"Khalifa HO, Watanabe A, Kamei K. Genetic Mutations in FKS1 Gene associated with acquired echinocandin resistance in Candida parapsilosis Complex. Mycopathologia. 2024;189(3):40. https:\/\/doi.org\/10.1007\/s11046-024-00847-0.","journal-title":"Mycopathologia"},{"issue":"10","key":"1008_CR52","doi-asserted-by":"publisher","first-page":"891.e5","DOI":"10.1016\/j.cmi.2016.07.025","volume":"22","author":"S Imbert","year":"2016","unstructured":"Imbert S, Castain L, Pons A, et al. Discontinuation of echinocandin and azole treatments led to the disappearance of an FKS alteration but not azole resistance during clonal Candida glabrata persistent candidaemia. Clin Microbiol Infect. 2016;22(10):891.e5-891.e8. https:\/\/doi.org\/10.1016\/j.cmi.2016.07.025.","journal-title":"Clin Microbiol Infect"},{"issue":"3","key":"1008_CR53","doi-asserted-by":"publisher","first-page":"249","DOI":"10.3390\/jof8030249","volume":"8","author":"L Galia","year":"2022","unstructured":"Galia L, Pezzani MD, Compri M, et al. Surveillance of antifungal resistance in candidemia fails to inform antifungal stewardship in European countries. J Fungi. 2022;8(3):249.","journal-title":"J Fungi"},{"issue":"12","key":"1008_CR54","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1080\/14740338.2023.2280137","volume":"22","author":"AK Gupta","year":"2023","unstructured":"Gupta AK, Haas-Neill S, Talukder M. The safety of oral antifungals for the treatment of onychomycosis. Expert Opin Drug Saf. 2023;22(12):1169\u201378. https:\/\/doi.org\/10.1080\/14740338.2023.2280137.","journal-title":"Expert Opin Drug Saf"},{"issue":"4","key":"1008_CR55","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1093\/jac\/dkx480","volume":"73","author":"A Chowdhary","year":"2018","unstructured":"Chowdhary A, Prakash A, Sharma C, et al. A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009\u201317) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance. J Antimicrob Chemother. 2018;73(4):891\u20139.","journal-title":"J Antimicrob Chemother"},{"issue":"1","key":"1008_CR56","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-88656-3","volume":"15","author":"SH Ahmed","year":"2025","unstructured":"Ahmed SH, El-Kholy IMA, El-Mehalawy AA, et al. Molecular characterization of some multidrug resistant Candida auris in Egypt. Sci Rep. 2025;15(1):4917.","journal-title":"Sci Rep"},{"key":"1008_CR57","doi-asserted-by":"publisher","first-page":"642358","DOI":"10.3389\/fcimb.2021.642358","volume":"11","author":"A Gamal","year":"2021","unstructured":"Gamal A, Chu S, McCormick TS, et al. Ibrexafungerp, a novel oral triterpenoid antifungal in development: Overview of antifungal activity against Candida glabrata. Front Cell Infect Microbiol. 2021;11:642358.","journal-title":"Front Cell Infect Microbiol"},{"issue":"8","key":"1008_CR58","doi-asserted-by":"publisher","first-page":"1154.e5","DOI":"10.1016\/j.cmi.2022.04.003","volume":"28","author":"A Mesquida","year":"2022","unstructured":"Mesquida A, D\u00edaz-Garc\u00eda J, S\u00e1nchez-Carrillo C, et al. \u0394F659 and F659S substitutions at the HS1 of FKS2 gene, along with E655A and W715L upstream and downstream substitutions, correlate with high ibrexafungerp MICs against Candida glabrata. Clin Microbiol Infect. 2022;28(8):1154.e5-1154.e8.","journal-title":"Clin Microbiol Infect"},{"key":"1008_CR59","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2024.243360","author":"J Raposa","year":"2025","unstructured":"Raposa J, Vazquez JA. New pharmacotherapeutic strategies for drug-resistant Candida infections: a review. Expert Opin Pharmacother. 2025. https:\/\/doi.org\/10.1080\/14656566.2024.243360.","journal-title":"Expert Opin Pharmacother"},{"issue":"6","key":"1008_CR60","doi-asserted-by":"publisher","first-page":"ofae072","DOI":"10.1093\/ofid\/ofae072","volume":"11","author":"RM Wake","year":"2024","unstructured":"Wake RM, Allebone-Salt PE, John LLH, et al. Optimizing the treatment of invasive Candidiasis-A case for combination therapy. Open Forum Infect Dis. 2024;11(6):ofae072. https:\/\/doi.org\/10.1093\/ofid\/ofae072.","journal-title":"Open Forum Infect Dis"}],"container-title":["Mycopathologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-025-01008-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11046-025-01008-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-025-01008-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T05:15:11Z","timestamp":1764134111000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11046-025-01008-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,3]]},"references-count":60,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1008"],"URL":"https:\/\/doi.org\/10.1007\/s11046-025-01008-7","relation":{},"ISSN":["0301-486X","1573-0832"],"issn-type":[{"value":"0301-486X","type":"print"},{"value":"1573-0832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,3]]},"assertion":[{"value":"11 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No potential conflict of interest was reported by the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study did not require institutional\/national ethics committee approval because: No human participants or vertebrate animals were involved in any experimental procedures.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}],"article-number":"95"}}