{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T08:14:19Z","timestamp":1771056859778,"version":"3.50.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/14235-3"],"award-info":[{"award-number":["2020\/14235-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["308901\/2023-1"],"award-info":[{"award-number":["308901\/2023-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mycopathologia"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s11046-025-01038-1","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T03:32:46Z","timestamp":1765942366000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aspartic Proteases Drive Stress Response, Morphogenesis, and Macrophage Interaction in Sporothrix brasiliensis"],"prefix":"10.1007","volume":"191","author":[{"given":"Leonardo Brogliato","family":"de Moraes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilson Dias","family":"Segura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinaldo Souza","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Fernandes","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah Corr\u00eaa","family":"Fuzeti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen Spadari","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wagner Luiz","family":"Batista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"issue":"2","key":"1038_CR1","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3390\/jof4020062","volume":"4","author":"R Arenas","year":"2018","unstructured":"Arenas R, S\u00e1nchez-Cardenas CD, Ramirez-Hobak L, et al. Sporotrichosis: from KOH to molecular biology. J Fungi. 2018;4(2):62. https:\/\/doi.org\/10.3390\/jof4020062.","journal-title":"J Fungi"},{"key":"1038_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.simyco.2021.100129","volume":"100","author":"J\u00c1 de Carvalho","year":"2021","unstructured":"de Carvalho J\u00c1, Beale MA, Hagen F, et al. Trends in the molecular epidemiology and population genetics of emerging Sporothrix species. Stud Mycol. 2021;100:100129. https:\/\/doi.org\/10.1016\/j.simyco.2021.100129.","journal-title":"Stud Mycol"},{"issue":"11","key":"1038_CR3","doi-asserted-by":"publisher","first-page":"2152","DOI":"10.3390\/microorganisms10112152","volume":"10","author":"CM Alvarez","year":"2022","unstructured":"Alvarez CM, Oliveira MME, Pires RH. Sporotrichosis: a review of a neglected disease in the last 50 years in Brazil. Microorganisms. 2022;10(11):2152. https:\/\/doi.org\/10.3390\/microorganisms10112152.","journal-title":"Microorganisms"},{"issue":"3","key":"1038_CR4","doi-asserted-by":"publisher","first-page":"318","DOI":"10.3390\/jof8030318","volume":"8","author":"LC Garc\u00eda-Carnero","year":"2022","unstructured":"Garc\u00eda-Carnero LC, Mart\u00ednez-\u00c1lvarez JA. Virulence factors of Sporothrix schenckii. J Fungi. 2022;8(3):318. https:\/\/doi.org\/10.3390\/jof8030318.","journal-title":"J Fungi"},{"issue":"1","key":"1038_CR5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006077","volume":"13","author":"IDF Gremi\u00e3o","year":"2017","unstructured":"Gremi\u00e3o IDF, Miranda LHM, Reis EG, et al. Zoonotic epidemic of sporotrichosis: cat to human transmission. PLoS Pathog. 2017;13(1):e1006077. https:\/\/doi.org\/10.1371\/journal.ppat.1006077.","journal-title":"PLoS Pathog"},{"issue":"8","key":"1038_CR6","doi-asserted-by":"publisher","first-page":"776","DOI":"10.3390\/jof8080776","volume":"8","author":"AM Rodrigues","year":"2022","unstructured":"Rodrigues AM, Gon\u00e7alves SS, de Carvalho JA, et al. Current progress on epidemiology, diagnosis, and treatment of sporotrichosis and their future trends. J Fungi. 2022;8(8):776. https:\/\/doi.org\/10.3390\/jof8080776.","journal-title":"J Fungi"},{"issue":"4","key":"1038_CR7","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1128\/CMR.00007-11","volume":"24","author":"MB Barros","year":"2011","unstructured":"Barros MB, Almeida-Paes R, Schubach AO. Sporothrix schenckii and Sporotrichosis. Clin Microbiol Rev. 2011;24(4):633\u201354. https:\/\/doi.org\/10.1128\/CMR.00007-11.","journal-title":"Clin Microbiol Rev"},{"key":"1038_CR8","doi-asserted-by":"publisher","unstructured":"Mialski R, Oliveira Jr JN, Silva LH, et al. Chronic meningitis and hydrocephalus due to Sporothrix brasiliensis in immunocompetent adults: a challenging entity. Open Forum Infectious Diseases. 2018;5(5):ofy081. https:\/\/doi.org\/10.1093\/ofid\/ofy081.","DOI":"10.1093\/ofid\/ofy081"},{"issue":"5","key":"1038_CR9","doi-asserted-by":"publisher","first-page":"533","DOI":"10.3390\/jof9050533","volume":"9","author":"M G\u00f3mez-Gaviria","year":"2023","unstructured":"G\u00f3mez-Gaviria M, Mart\u00ednez-\u00c1lvarez JA, Mora-Montes HM. Current progress in Sporothrix brasiliensis basic aspects. J Fungi. 2023;9(5):533. https:\/\/doi.org\/10.3390\/jof9050533.","journal-title":"J Fungi"},{"issue":"11","key":"1038_CR10","first-page":"1223","volume":"97","author":"T Sanada","year":"1987","unstructured":"Sanada T. Isolation and characterization of extracellular proteinases from Sporothrix schenckii. Jpn J Dermatol. 1987;97(11):1223\u201330.","journal-title":"Jpn J Dermatol"},{"issue":"2","key":"1038_CR11","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/BF01365082","volume":"123","author":"T Yoshiike","year":"1993","unstructured":"Yoshiike T, Lei PC, Komatsuzaki H, Ogawa H. Antibody raised against extracellular proteinases of Sporothrix schenckii in S. schenckii inoculated hairless mice. Mycopathologia. 1993;123(2):69\u201373. https:\/\/doi.org\/10.1007\/BF01365082.","journal-title":"Mycopathologia"},{"issue":"9","key":"1038_CR12","doi-asserted-by":"publisher","first-page":"4775","DOI":"10.3390\/ijms25094775","volume":"25","author":"G Bras","year":"2024","unstructured":"Bras G, Satala D, Juszczak M, Kulig K, et al. Secreted aspartic proteinases: key factors in Candida infections and host-pathogen interactions. Int J Mol Sci. 2024;25(9):4775. https:\/\/doi.org\/10.3390\/ijms25094775.","journal-title":"Int J Mol Sci"},{"key":"1038_CR13","doi-asserted-by":"publisher","first-page":"295","DOI":"10.2217\/fmb-2022-0143","volume":"18","author":"A Kulshrestha","year":"2023","unstructured":"Kulshrestha A, Gupta P. Secreted aspartyl proteases family: a perspective review on the regulation of fungal pathogenesis. Future Microbiol. 2023;18:295\u2013309. https:\/\/doi.org\/10.2217\/fmb-2022-0143.","journal-title":"Future Microbiol"},{"issue":"9","key":"1038_CR14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006806","volume":"12","author":"DG Castilho","year":"2018","unstructured":"Castilho DG, Chaves AFA, Navarro MV, Concei\u00e7\u00e3o PM, et al. Secreted aspartyl proteinase (PbSap) contributes to the virulence of Paracoccidioides brasiliensis infection. PLoS Negl Trop Dis. 2018;12(9):e0006806. https:\/\/doi.org\/10.1371\/journal.pntd.0006806.","journal-title":"PLoS Negl Trop Dis"},{"issue":"3","key":"1038_CR15","doi-asserted-by":"publisher","first-page":"375","DOI":"10.3390\/jof9030375","volume":"9","author":"RS Silva","year":"2023","unstructured":"Silva RS, Segura WD, Oliveira RS, et al. Characterization of aspartic proteases from Paracoccidioides brasiliensis and their role in fungal thermo-dimorphism. J Fungi. 2023;9(3):375. https:\/\/doi.org\/10.3390\/jof9030375.","journal-title":"J Fungi"},{"issue":"10","key":"1038_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075656","volume":"8","author":"RA Castro","year":"2013","unstructured":"Castro RA, Kubitschek-Barreira PH, Teixeira PA, Sanches GF, Teixeira MM, et al. Differences in cell morphometry, cell wall topography and gp70 expression correlate with the virulence of Sporothrix brasiliensis clinical isolates. PLoS ONE. 2013;8(10):e75656. https:\/\/doi.org\/10.1371\/journal.pone.0075656.","journal-title":"PLoS ONE"},{"issue":"4","key":"1038_CR17","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1128\/AAC.47.4.1376-1381.2003","volume":"47","author":"T Nakai","year":"2003","unstructured":"Nakai T, Uno J, Ikeda F, Tawara S, et al. In vitro antifungal activity of micafungin (FK463) against dimorphic fungi: comparison of yeast-like and mycelial forms. Antimicrob Agents Chemother. 2003;47(4):1376\u201381. https:\/\/doi.org\/10.1128\/AAC.47.4.1376-1381.2003.","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"1038_CR18","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1080\/02681219180000061","volume":"29","author":"ZP Camargo","year":"1991","unstructured":"Camargo ZP, Taborda CP, Rodrigues EG, Travassos LR. The use of cell-free antigens of Paracoccidioides brasiliensis in serological tests. J Med Vet Mycol. 1991;29(1):31\u20138.","journal-title":"J Med Vet Mycol"},{"issue":"24","key":"1038_CR19","doi-asserted-by":"publisher","first-page":"7478","DOI":"10.1073\/pnas.1507082112","volume":"112","author":"AJ O'Donoghue","year":"2015","unstructured":"O\u2019Donoghue AJ, Knudsen GM, Beekman C, Perry JA, et al. Destructin-1 is a collagen-degrading endopeptidase secreted by Pseudogymnoascus destructans, the causative agent of white-nose syndrome. Proc Natl Acad Sci U S A. 2015;112(24):7478\u201383. https:\/\/doi.org\/10.1073\/pnas.1507082112.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1038_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2024.106773","volume":"193","author":"SJ Lim","year":"2024","unstructured":"Lim SJ, Noor NDM, Sabri S, Ali MSM, et al. Extracellular BSA-degrading SAPs in the rare pathogen Meyerozyma guilliermondii strain SO as potential virulence factors in candidiasis. Microb Pathog. 2024;193:106773. https:\/\/doi.org\/10.1016\/j.micpath.2024.106773.","journal-title":"Microb Pathog"},{"issue":"7","key":"1038_CR21","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.micinf.2008.04.012","volume":"10","author":"AF Popi","year":"2008","unstructured":"Popi AF, Godoy LC, Xander P, Lopes JD, Mariano M. B-1 cells facilitate Paracoccidioides brasiliensis infection in mice via IL-10 secretion. Microbes Infect. 2008;10(7):817\u201324. https:\/\/doi.org\/10.1016\/j.micinf.2008.04.012.","journal-title":"Microbes Infect"},{"issue":"6","key":"1038_CR22","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1093\/molbev\/msw046","volume":"33","author":"J Huerta-Cepas","year":"2016","unstructured":"Huerta-Cepas J, Serra F, Bork P. ETE 3: Reconstruction, analysis, and visualization of phylogenomic data. Mol Biol Evol. 2016;33(6):1635\u20138. https:\/\/doi.org\/10.1093\/molbev\/msw046.","journal-title":"Mol Biol Evol"},{"key":"1038_CR23","doi-asserted-by":"publisher","unstructured":"Price MN, Dehal PS, Arkin AP. FastTree 2--approximately maximum-likelihood trees for large alignments. PLoS One. 2010;5(3):e9490. https:\/\/doi.org.https:\/\/doi.org\/10.1371\/journal.pone.0009490.","DOI":"10.1371\/journal.pone.0009490"},{"key":"1038_CR24","doi-asserted-by":"publisher","unstructured":"Naeem M, Manzoor S, Abid MUH, et al. Fungal Proteases as Emerging Biocatalysts to Meet the Current Challenges and Recent Developments in Biomedical Therapies: An Updated Review. J Fungi (Basel). 2022;8(2):109. https:\/\/doi.org.https:\/\/doi.org\/10.3390\/jof8020109","DOI":"10.3390\/jof8020109"},{"issue":"2","key":"1038_CR25","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1080\/15572536.2004.11833118","volume":"95","author":"YM Flores","year":"2003","unstructured":"Flores YM, Rodr\u00edguez CH, Herrera JR, Tanaca LV. Proteinases and exopeptidases from the phytopathogenic fungus Ustilago maydis. Mycologia. 2003;95(2):327\u201339.","journal-title":"Mycologia"},{"issue":"3","key":"1038_CR26","doi-asserted-by":"publisher","first-page":"295","DOI":"10.2174\/1389203720666191007103004","volume":"21","author":"AK Tamez-Castrell\u00f3n","year":"2020","unstructured":"Tamez-Castrell\u00f3n AK, Romeo O, Garc\u00eda-Carnero LC, et al. Virulence factors in Sporothrix schenckii, one of the causative agents of sporotrichosis. Curr Protein Pept Sci. 2020;21(3):295\u2013312. https:\/\/doi.org\/10.2174\/1389203720666191007103004.","journal-title":"Curr Protein Pept Sci"},{"issue":"1","key":"1038_CR27","doi-asserted-by":"publisher","first-page":"58","DOI":"10.19106\/JMedSci004801201606","volume":"48","author":"T Wibawa","year":"2016","unstructured":"Wibawa T. The role of virulence factors in Candida albicans pathogenicity. J Med Sci. 2016;48(1):58\u201368. https:\/\/doi.org\/10.19106\/JMedSci004801201606.","journal-title":"J Med Sci"},{"issue":"1","key":"1038_CR28","doi-asserted-by":"publisher","first-page":"15","DOI":"10.33073\/pjm-2014-002","volume":"63","author":"M Staniszewska","year":"2014","unstructured":"Staniszewska M, Bondaryk M, Malewski T, Kurzatkowski W. Quantitative expression of Candida albicans aspartyl proteinase genes SAP7, SAP8, SAP9, SAP10 in human serum in vitro. Pol J Microbiol. 2014;63(1):15\u201320.","journal-title":"Pol J Microbiol"},{"key":"1038_CR29","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1111\/1574-6976.12020","volume":"37","author":"M Delic","year":"2013","unstructured":"Delic M, Valli M, Graf AB, et al. The secretory pathway: exploring yeast diversity. FEMS Microbiol Rev. 2013;37:872\u2013914. https:\/\/doi.org\/10.1111\/1574-6976.12020.","journal-title":"FEMS Microbiol Rev"},{"key":"1038_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcsw.2020.100045","volume":"6","author":"MJ Cohen","year":"2020","unstructured":"Cohen MJ, Chirico WJ, Lipke PN. Through the back door: unconventional protein secretion. Cell Surf. 2020;6:100045. https:\/\/doi.org\/10.1016\/j.tcsw.2020.100045.","journal-title":"Cell Surf"},{"issue":"16","key":"1038_CR31","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1021\/acs.biochem.2c00239","volume":"61","author":"K Oda","year":"2022","unstructured":"Oda K, Dunn BM, Wlodawer A. Serine-carboxyl peptidases, sedolisins: from discovery to evolution. Biochemistry. 2022;61(16):1643\u201364. https:\/\/doi.org\/10.1021\/acs.biochem.2c00239.","journal-title":"Biochemistry"},{"issue":"2","key":"1038_CR32","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S0308-8146(02)00126-7","volume":"79","author":"S Bendicho","year":"2002","unstructured":"Bendicho S, Mart\u00ed G, Hern\u00e1ndez T, Mart\u00edn O. Determination of proteolytic activity in different milk. Chemistry. 2002;79(2):245\u20139. https:\/\/doi.org\/10.1016\/S0308-8146(02)00126-7.","journal-title":"Chemistry"},{"issue":"5","key":"1038_CR33","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s11046-010-9386-2","volume":"171","author":"I Yike","year":"2011","unstructured":"Yike I. Fungal proteases and their pathophysiological effects. Mycopathologia. 2011;171(5):299\u2013323. https:\/\/doi.org\/10.1007\/s11046-010-9386-2.","journal-title":"Mycopathologia"},{"issue":"1-2","key":"1038_CR34","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1159\/000479825","volume":"52","author":"SF Amaral","year":"2018","unstructured":"Amaral SF, Scaffa PMC, Rodrigues RDS, et al. Dynamic influence of pH on metalloproteinase activity in human coronal and radicular dentin. Caries Res. 2018;52(1\u20132):113\u20138.","journal-title":"Caries Res"},{"issue":"2","key":"1038_CR35","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/BF00245214","volume":"158","author":"M Kopeck\u00e1","year":"1992","unstructured":"Kopeck\u00e1 M, Gabriel M. The influence of Congo red on the cell wall and (1\u21923)-\u03b2-D-glucan microfibril biogenesis in Saccharomyces cerevisiae. Arch Microbiol. 1992;158(2):115\u201326. https:\/\/doi.org\/10.1007\/BF00245214.","journal-title":"Arch Microbiol"},{"issue":"3","key":"1038_CR36","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1128\/jb.163.3.1180-1185.1985","volume":"163","author":"C Roncero","year":"1985","unstructured":"Roncero C, Duran A. Effect of Calcofluor White and Congo red on fungal cell wall morphogenesis: in vivo activation of chitin polymerization. J Bacteriol. 1985;163(3):1180\u20135.","journal-title":"J Bacteriol"},{"issue":"5","key":"1038_CR37","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1038\/nprot.2006.397","volume":"1","author":"AFJ Ram","year":"2006","unstructured":"Ram AFJ, Klis FM. Identification of fungal cell wall mutants using susceptibility assays based on Calcofluor white and Congo red. Nat Protoc. 2006;1(5):2253\u20136. https:\/\/doi.org\/10.1038\/nprot.2006.397.","journal-title":"Nat Protoc"},{"issue":"10","key":"1038_CR38","doi-asserted-by":"publisher","first-page":"9149","DOI":"10.1074\/jbc.M411062200","volume":"280","author":"F Vilella","year":"2005","unstructured":"Vilella F, Herrero E, Jordi Torres J, et al. Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress. J Biol Chem. 2005;280(10):9149\u201359. https:\/\/doi.org\/10.1074\/jbc.M411062200.","journal-title":"J Biol Chem"},{"issue":"8","key":"1038_CR39","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1128\/EC.4.8.1364-1374.2005","volume":"4","author":"DJ Krysan","year":"2005","unstructured":"Krysan DJ, Ting EL, Abeijon C, et al. Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae. Eukaryot Cell. 2005;4(8):1364\u201374. https:\/\/doi.org\/10.1128\/EC.4.8.1364-1374.2005.","journal-title":"Eukaryot Cell"},{"key":"1038_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.702779","volume":"12","author":"R Garcia-Rubio","year":"2021","unstructured":"Garcia-Rubio R, Hernandez RY, Clear A, Healey KR, et al. Critical assessment of cell wall integrity factors contributing to in vivo echinocandin tolerance and resistance in Candida glabrata. Front Microbiol. 2021;12:702779. https:\/\/doi.org\/10.3389\/fmicb.2021.702779.","journal-title":"Front Microbiol"},{"issue":"7","key":"1038_CR41","doi-asserted-by":"publisher","first-page":"3689","DOI":"10.1128\/IAI.70.7.3689-3700.2002","volume":"70","author":"A Felk","year":"2002","unstructured":"Felk A, Kretschmar M, Albrecht A, et al. Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organs. Infect Immun. 2002;70(7):3689\u2013700. https:\/\/doi.org\/10.1128\/IAI.70.7.3689-3700.2002.","journal-title":"Infect Immun"},{"issue":"1","key":"1038_CR42","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1080\/21505594.2019.1593776","volume":"10","author":"M Payne","year":"2019","unstructured":"Payne M, Weerasinghe H, Tedja I, Andrianopoulos A. A unique aspartyl protease gene expansion in Talaromyces marneffei plays a role in growth inside host phagocytes. Virulence. 2019;10(1):277\u201391. https:\/\/doi.org\/10.1080\/21505594.2019.1593776.","journal-title":"Virulence"},{"issue":"8","key":"1038_CR43","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1111\/mpp.12240","volume":"16","author":"CV Soberanes-Guti\u00e9rrez","year":"2015","unstructured":"Soberanes-Guti\u00e9rrez CV, Ju\u00e1rez-Montiel M, Olgu\u00edn-Rodr\u00edguez O, et al. The pep4 gene encoding proteinase A is involved in dimorphism and pathogenesis of Ustilago maydis. Mol Plant Pathol. 2015;16(8):837\u201346. https:\/\/doi.org\/10.1111\/mpp.12240.","journal-title":"Mol Plant Pathol"},{"issue":"3","key":"1038_CR44","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1002\/yea.964","volume":"20","author":"MSS Felipe","year":"2003","unstructured":"Felipe MSS, Andrade RV, Petrofeza SS, et al. Transcriptome characterization of the dimorphic and pathogenic fungus Paracoccidioides brasiliensis by EST analysis. Yeast. 2003;20(3):263\u201371. https:\/\/doi.org\/10.1002\/yea.964.","journal-title":"Yeast"},{"issue":"Suppl 1","key":"1038_CR45","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1080\/mmy.38.s1.79.86","volume":"38","author":"G San-Blas","year":"2000","unstructured":"San-Blas G, Travassos LR, Fries BC, Goldman DL, et al. Fungal morphogenesis and virulence. Med Mycol. 2000;38(Suppl 1):79\u201386.","journal-title":"Med Mycol"},{"issue":"6","key":"1038_CR46","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1093\/femsre\/fuv035","volume":"39","author":"KJ Boyce","year":"2015","unstructured":"Boyce KJ, Andrianopoulos A. Fungal dimorphism: the switch from hyphae to yeast is a specialized morphogenetic adaptation allowing colonization of a host. FEMS Microbiol Rev. 2015;39(6):797\u2013811. https:\/\/doi.org\/10.1093\/femsre\/fuv035.","journal-title":"FEMS Microbiol Rev"},{"issue":"2","key":"1038_CR47","first-page":"127","volume":"51","author":"M Staniszewska","year":"2012","unstructured":"Staniszewska M, Bondaryk M, Siennicka K, Pilat J, et al. Role of aspartic proteinases in Candida albicans virulence. Part I. Substrate specificity of aspartic proteinases and Candida albicans pathogenesis. Post\u0119py Mikrobiologii. 2012;51(2):127\u201335.","journal-title":"Post\u0119py Mikrobiologii."},{"key":"1038_CR48","doi-asserted-by":"publisher","unstructured":"Padr\u00f3-Villegas L, G\u00f3mez-Gaviria M, Mart\u00ednez-Duncker I, et al. Gp70 from Sporothrix brasiliensis is a cell wall protein required for adhesion, proper interaction with innate immune cells, and virulence. Cell Surf. 2025;6:13:100139. https:\/\/doi.org.https:\/\/doi.org\/10.1016\/j.tcsw.2024.100139.","DOI":"10.1016\/j.tcsw.2024.100139"}],"container-title":["Mycopathologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-025-01038-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11046-025-01038-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-025-01038-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T07:53:21Z","timestamp":1771055601000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11046-025-01038-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,17]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["1038"],"URL":"https:\/\/doi.org\/10.1007\/s11046-025-01038-1","relation":{},"ISSN":["0301-486X","1573-0832"],"issn-type":[{"value":"0301-486X","type":"print"},{"value":"1573-0832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,17]]},"assertion":[{"value":"28 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"7"}}