{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T08:14:13Z","timestamp":1771056853631,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Clinical High-tech, Major, and Characteristic Technology Projects in Guangzhou","award":["2026P-TS053"],"award-info":[{"award-number":["2026P-TS053"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mycopathologia"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s11046-025-01044-3","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T19:32:34Z","timestamp":1768419154000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of the Efficacy and Safety of Different Antifungal Regimen Combinations in Non-HIV and Non-transplant Cryptococcal Meningitis Patients with High Cryptococcal Count"],"prefix":"10.1007","volume":"191","author":[{"given":"Junyu","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongcheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaxin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zifeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuhua","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"issue":"8","key":"1044_CR1","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/S1473-3099(17)30243-8","volume":"17","author":"R Rajasingham","year":"2017","unstructured":"Rajasingham R, Smith RM, Park BJ, Jarvis JN, Govender NP, Chiller TM, et al. Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis. Lancet Infect Dis. 2017;17(8):873\u201381.","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"1044_CR2","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/nrneurol.2016.167","volume":"13","author":"PR Williamson","year":"2017","unstructured":"Williamson PR, Jarvis JN, Panackal AA, Fisher MC, Molloy SF, Loyse A, et al. Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy. Nat Rev Neurol. 2017;13(1):13\u201324.","journal-title":"Nat Rev Neurol"},{"issue":"8","key":"1044_CR3","doi-asserted-by":"publisher","first-page":"e495","DOI":"10.1016\/S1473-3099(23)00731-4","volume":"24","author":"CC Chang","year":"2024","unstructured":"Chang CC, Harrison TS, Bicanic TA, Chayakulkeeree M, Sorrell TC, Warris A, et al. Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM. Lancet Infect Dis. 2024;24(8):e495\u2013512.","journal-title":"Lancet Infect Dis"},{"issue":"4","key":"1044_CR4","doi-asserted-by":"publisher","first-page":"570","DOI":"10.3109\/13693780903437876","volume":"48","author":"LP Zhu","year":"2010","unstructured":"Zhu LP, Wu JQ, Xu B, Ou XT, Zhang QQ, Weng XH. Cryptococcal meningitis in non-HIV-infected patients in a Chinese tertiary care hospital, 1997\u20132007. Med Mycol. 2010;48(4):570\u20139.","journal-title":"Med Mycol"},{"issue":"4","key":"1044_CR5","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1053\/jinf.2001.0916","volume":"43","author":"P Pitisuttithum","year":"2001","unstructured":"Pitisuttithum P, Tansuphasawadikul S, Simpson AJ, Howe PA, White NJ. A prospective study of AIDS-associated cryptococcal meningitis in Thailand treated with high-dose amphotericin B. J Infect. 2001;43(4):226\u201333.","journal-title":"J Infect"},{"issue":"1","key":"1044_CR6","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.diagmicrobio.2012.01.014","volume":"73","author":"JE Vidal","year":"2012","unstructured":"Vidal JE, Gerhardt J, de Peixoto Miranda EJ, Dauar RF, Oliveira Filho GS, de Penalva Oliveira AC, et al. Role of quantitative CSF microscopy to predict culture status and outcome in HIV-associated cryptococcal meningitis in a Brazilian cohort. Diagn Microbiol Infect Dis. 2012;73(1):68\u201373.","journal-title":"Diagn Microbiol Infect Dis"},{"key":"1044_CR7","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.2217\/fmb-2020-0086","volume":"15","author":"K Zhang","year":"2020","unstructured":"Zhang K, Li H, Zhang L, Liao W, Ling L, Li X, et al. Cerebrospinal fluid microscopy as an index for predicting the prognosis of cryptococcal meningitis patients with and without HIV. Future Microbiol. 2020;15:1645\u201352.","journal-title":"Future Microbiol"},{"issue":"1","key":"1044_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-022-07118-7","volume":"22","author":"L de Oliveira","year":"2022","unstructured":"de Oliveira L, Melhem MSC, Buccheri R, Chagas OJ, Vidal JE, Diaz-Quijano FA. Early clinical and microbiological predictors of outcome in hospitalized patients with cryptococcal meningitis. BMC Infect Dis. 2022;22(1):138.","journal-title":"BMC Infect Dis"},{"issue":"3","key":"1044_CR9","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1086\/649858","volume":"50","author":"JR Perfect","year":"2010","unstructured":"Perfect JR, Dismukes WE, Dromer F, Goldman DL, Graybill JR, Hamill RJ, et al. Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america. Clin Infect Dis. 2010;50(3):291\u2013322.","journal-title":"Clin Infect Dis"},{"issue":"5","key":"1044_CR10","first-page":"317","volume":"57","author":"ZY Liu","year":"2018","unstructured":"Liu ZY, Wang GQ, Zhu LP, Lyu XJ, Zhang QQ, Yu YS, et al. Expert consensus on the diagnosis and treatment of cryptococcal meningitis. Zhonghua Nei Ke Za Zhi. 2018;57(5):317\u201323.","journal-title":"Zhonghua Nei Ke Za Zhi"},{"issue":"5","key":"1044_CR11","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1080\/01616412.2018.1447319","volume":"40","author":"L Xu","year":"2018","unstructured":"Xu L, Liu J, Zhang Q, Li M, Liao J, Kuang W, et al. Triple therapy versus amphotericin B plus flucytosine for the treatment of non-HIV- and non-transplant-associated cryptococcal meningitis: retrospective cohort study. Neurol Res. 2018;40(5):398\u2013404.","journal-title":"Neurol Res"},{"issue":"1","key":"1044_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-022-02803-1","volume":"22","author":"J Liu","year":"2022","unstructured":"Liu J, Liu J, Su X, Yang L, Wang Y, Wang A, et al. Amphotericin B plus fluorocytosine combined with voriconazole for the treatment of non-HIV and non-transplant-associated cryptococcal meningitis: a retrospective study. BMC Neurol. 2022;22(1):274.","journal-title":"BMC Neurol"},{"issue":"8","key":"1044_CR13","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1111\/myc.12944","volume":"62","author":"Z Li","year":"2019","unstructured":"Li Z, Liu Y, Chong Y, Li X, Jie Y, Zheng X, et al. Fluconazole plus flucytosine is a good alternative therapy for non-HIV and non-transplant-associated cryptococcal meningitis: a retrospective cohort study. Mycoses. 2019;62(8):686\u201391.","journal-title":"Mycoses"},{"issue":"1","key":"1044_CR14","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-020-05510-9","volume":"20","author":"M Li","year":"2020","unstructured":"Li M, Liu J, Deng X, Gan Q, Wang Y, Xu X, et al. Triple therapy combined with ventriculoperitoneal shunts can improve neurological function and shorten hospitalization time in non-HIV cryptococcal meningitis patients with increased intracranial pressure. BMC Infect Dis. 2020;20(1):844.","journal-title":"BMC Infect Dis"},{"issue":"6503","key":"1044_CR15","first-page":"582","volume":"1","author":"STREPTOMYCIN treatment of tuberculous meningitis","year":"1948","unstructured":"STREPTOMYCIN treatment of tuberculous meningitis. Lancet. 1948;1(6503):582\u201396.","journal-title":"Lancet"},{"issue":"5","key":"1044_CR16","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1086\/590566","volume":"47","author":"BH Segal","year":"2008","unstructured":"Segal BH, Herbrecht R, Stevens DA, Ostrosky-Zeichner L, Sobel J, Viscoli C, et al. Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria. Clin Infect Dis. 2008;47(5):674\u201383.","journal-title":"Clin Infect Dis"},{"issue":"1","key":"1044_CR17","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1093\/cid\/ciu711","volume":"60","author":"HY Sun","year":"2015","unstructured":"Sun HY, Alexander BD, Huprikar S, Forrest GN, Bruno D, Lyon GM, et al. Predictors of immune reconstitution syndrome in organ transplant recipients with cryptococcosis: implications for the management of immunosuppression. Clin Infect Dis. 2015;60(1):36\u201344.","journal-title":"Clin Infect Dis"},{"issue":"4","key":"1044_CR18","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad158","volume":"10","author":"Z Su","year":"2023","unstructured":"Su Z, Luo C, Dai K, Yuan D, Qin BE, Gu M, et al. Failure of early mycological clearance in HIV-negative cryptococcal meningitis. Open Forum Infect Dis. 2023;10(4):ofad158.","journal-title":"Open Forum Infect Dis"},{"key":"1044_CR19","unstructured":"Zhu Liping WZ, Ming Shi, Yao Zhong, pan Xiaozhang, Weng Xinhua: Adverse reactions and prevention of intravenous amphotericin in the treatment of cryptococcal meningitis. Chinese Journal of anti infective chemotherapy 2002, 2."},{"issue":"1","key":"1044_CR20","doi-asserted-by":"publisher","first-page":"76","DOI":"10.4103\/0019-509X.48605","volume":"46","author":"AV Bamba","year":"2009","unstructured":"Bamba AV, Jadhav MP, Prabhu R, Ray S, Gogtay NJ, Jijina FF, et al. Refractory hypokalemia due to conventional amphotericin B in patients with leukemia. Indian J Cancer. 2009;46(1):76\u20137.","journal-title":"Indian J Cancer"},{"issue":"8","key":"1044_CR21","doi-asserted-by":"publisher","first-page":"3291","DOI":"10.1002\/jps.22109","volume":"99","author":"DR Luke","year":"2010","unstructured":"Luke DR, Tomaszewski K, Damle B, Schlamm HT. Review of the basic and clinical pharmacology of sulfobutylether-beta-cyclodextrin (SBECD). J Pharm Sci. 2010;99(8):3291\u2013301.","journal-title":"J Pharm Sci"},{"issue":"4","key":"1044_CR22","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.ijantimicag.2015.05.023","volume":"46","author":"RB Turner","year":"2015","unstructured":"Turner RB, Martello JL, Malhotra A. Worsening renal function in patients with baseline renal impairment treated with intravenous voriconazole: a systematic review. Int J Antimicrob Agents. 2015;46(4):362\u20136.","journal-title":"Int J Antimicrob Agents"}],"container-title":["Mycopathologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-025-01044-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11046-025-01044-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11046-025-01044-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T07:53:08Z","timestamp":1771055588000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11046-025-01044-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,14]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["1044"],"URL":"https:\/\/doi.org\/10.1007\/s11046-025-01044-3","relation":{},"ISSN":["0301-486X","1573-0832"],"issn-type":[{"value":"0301-486X","type":"print"},{"value":"1573-0832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,14]]},"assertion":[{"value":"8 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"20"}}